xenograft models

[Nature Nanotechnology] Scientists designed a ferritin-based As nanomedicine, As@Fn, that bound to leukemia cells with very high affinity, and efficiently delivered cytotoxic AsIII into a large diversity of leukemia cell lines and patient cells.

[Nature Communications] The authors showed that miR-126 enhanced MYC activity through the SPRED1/PLK2-ERK-MYC axis. Genetic deletion of miR-126 significantly reduced acute myeloid leukemia rate and extended survival in CBFB-MYH11 knock-in mice.

[Cancer Research] In multiple HCC patient-derived organoids and human tumor xenograft models, the drug combination, but neither single drug alone, markedly reduced tumor-initiating cancer cell frequency.

[Cancer Research] Investigators reported that supraphysiological levels of testosterone (SupraT) activated cytoplasmic nucleic acid sensors and induced growth inhibition of SupraT-sensitive prostate cancer cells.

[Cancer Research] Scientists reported that specific homozygous deletion of KDM6A in the adult mouse prostate epithelium strongly inhibited tumor progression initiated by the homozygous loss of PTEN. Mechanistically, KDM6A promoted prostate tumorigenesis and lipid metabolism by binding to the SREBP1c promoter which resulted in increased SREBP1c transcription.

[Cell Death & Disease] The authors explored the role of F-box and WD repeat domain containing 11 (FBXW11) in the development and metastasis of colorectal cancer (CRC). FBXW11 was overexpressed in colorectal tumor tissues and its overexpression was associated with a poor prognosis of CRC patients.