Cytochrome P450 1B1 Polymorphism Drives Cancer Cell Stemness and Patient Outcome in Head-and-Neck Carcinoma

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From head-and-neck squamous cell carcinoma cell lines not expressing CYP1B1, investigators generated isogenic derivatives expressing the two forms. Proliferation, invasiveness, stem cell characteristics, sensitivity to anticancer agents and transcriptome were analyzed.
[British Journal of Cancer]
Morvan, V. L., Richard, É., Cadars, M., Fessart, D., Broca-Brisson, L., Auzanneau, C., Pasquies, A., Modesto, A., Lusque, A., Mathoulin-Pélissier, S., Lansiaux, A., & Robert, J. (2020). Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma. British Journal of Cancer, 1–13. https://doi.org/10.1038/s41416-020-0932-5 Cite
Abstract