The Proton-Activated G Protein-Coupled Receptor GPR4 Regulates the Development of Osteoarthritis via Modulating CXCL12/CXCR7 Signaling

Investigators found that inhibition of G protein-coupled receptor 4 (GPR4) with the antagonist NE52-QQ57 ameliorated osteoarthritis progression in mice, promoted ECM production, and protected cartilage from degradation in human articular cartilage explants.