Microenvironmental Stiffness Mediates Cytoskeleton Re-Organization in Chondrocytes through Laminin-FAK Mechanotransduction

Scientists elucidated a new path in cytoskeleton re-organization in chondrocytes in response to changed substrate stiffnesses by characterizing the axis shift from the secreted extracellular protein laminin β1, focal adhesion complex protein FAK to microfilament bundling.