HspBP1 Is a Dual Function Regulatory Protein That Controls Both DNA Repair and Apoptosis in Breast Cancer Cells

Investigators showed that when Hsp70-binding protein 1 (HspBP1) was either knocked down or overexpressed in BRCA1-proficient breast cancer cells, there were profound changes in tumorigenesis, including anchorage-independent cell growth in vitro and in tumor formation in xenograft models.