CCR7 Expression in CD19 Chimeric Antigen Receptor-Engineered Natural Killer Cells Improves Migration toward CCL19-Expressing Lymphoma Cells and Increases Tumor Control in Mice with Human Lymphoma

Since Natural Killer (NK)-92 cells do not spontaneously express CCR7, clinical-grade activated NK cells were transfected with a non-viral vector containing the CCR7 receptor, an anti-CD19 CAR and a high-affinity CD16 Fc receptor.