Monocytes Transition to Macrophages within the Inflamed Vasculature via Monocyte CCR2 and Endothelial TNFR2

Investigators showed that monocytes acquired macrophage markers upon glomerulonephritis and may have been derived from CCR2+CX3CR1+ double-positive monocytes, which were preferentially recruited, dwelled within glomerular capillaries, and acquired proinflammatory characteristics in the nephritic kidney.