TY - JOUR TI - Cardiomyocyte Induction and Regeneration for Myocardial Infarction Treatment: Cell Sources and Administration Strategies AU - He, Lihong AU - Chen, Xiongbiao T2 - Advanced Healthcare Materials AB - Occlusion of coronary artery and subsequent damage or death of myocardium can lead to myocardial infarction (MI) and even heart failure—one of the leading causes of deaths world wide. Notably, myocardium has extremely limited regeneration potential due to the loss or death of cardiomyocytes (i.e., the cells of which the myocardium is comprised) upon MI. A variety of stem cells and stem cell-derived cardiovascular cells, in situ cardiac fibroblasts and endogenous proliferative epicardium, have been exploited to provide renewable cellular sources to treat injured myocardium. Also, different strategies, including direct injection of cell suspensions, bioactive molecules, or cell-incorporated biomaterials, and implantation of artificial cardiac scaffolds (e.g., cell sheets and cardiac patches), have been developed to deliver renewable cells and/or bioactive molecules to the MI site for the myocardium regeneration. This article briefly surveys cell sources and delivery strategies, along with biomaterials and their processing techniques, developed for MI treatment. Key issues and challenges, as well as recommendations for future research, are also discussed. DO - 10.1002/adhm.202001175 DP - Wiley Online Library VL - n/a IS - n/a SP - 2001175 LA - en SN - 2192-2659 ST - Cardiomyocyte Induction and Regeneration for Myocardial Infarction Treatment UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202001175 Y2 - 2020/10/01/18:23:01 KW - biomaterials KW - cardiac patches KW - cell sheets KW - cell-based therapy KW - in situ reprogramming ER -