TY - JOUR TI - Splenic hematopoietic and stromal cells in cancer progression AU - Steenbrugge, Jonas AU - Jaeghere, Emiel A. De AU - Meyer, Evelyne AU - Denys, Hannelore AU - Wever, Olivier De T2 - Cancer Research AB - Tumor-derived secretory factors orchestrate splenic hematopoietic and stromal cells to fuel metastasis. The spleen acts as a reservoir site for hematopoietic stem and progenitor cells, which are rapidly exploited as myeloid-derived suppressor cells at the cost of tumor-reactive lymphoid cells. Splenic erythroid progenitor cells and mesenchymal stromal cells contribute directly and indirectly to both tumor immune escape and the metastatic cascade. Animal models provide valuable mechanistic insights, but their translation to a clinical setting highlights specific challenges and open issues. In this review, we envision the exploitation of the spleen as a source for novel biomarkers and therapeutic approaches. DA - 2020/01/01/ PY - 2020 DO - 10.1158/0008-5472.CAN-20-2339 DP - cancerres.aacrjournals.org J2 - Cancer Res LA - en SN - 0008-5472, 1538-7445 UR - https://cancerres.aacrjournals.org/content/early/2020/09/30/0008-5472.CAN-20-2339 Y2 - 2020/10/01/17:44:30 ER -