TY - JOUR TI - MLLT10 in benign and malignant hematopoiesis AU - Deutsch, Jamie L. AU - Heath, Jessica L. T2 - Experimental Hematology AB -

Abstract

Non-random chromosomal translocations involving the putative transcription factor, Mixed Lineage Leukemia Translocated to, 10 (MLLT10, also known as AF10) are commonly observed in both acute myeloid and lymphoid leukemias, and are indicative of a poor prognosis. Despite the well described actions of oncogenic MLLT10 fusion proteins, the role of wild type MLLT10 in hematopoiesis is not well characterized. The protein structure and several interacting partners have been described, and give indications as to the potential functions of MLLT10. This review examines these aspects of MLLT10, contextualizing its function in benign and malignant hematopoiesis.

DA - 2020/06/19/ PY - 2020 DO - 10.1016/j.exphem.2020.06.002 DP - www.exphem.org VL - 0 IS - 0 J2 - Experimental Hematology LA - English SN - 0301-472X UR - https://www.exphem.org/article/S0301-472X(20)30241-1/abstract Y2 - 2020/06/23/17:34:25 ER -