TY - JOUR TI - Allogeneic hematopoietic cell transplantation efficacy in patients with Philadelphia chromosome-positive acute myeloid leukemia in complete remission AU - Mizuno, Shohei AU - Yanada, Masamitsu AU - Kawamura, Koji AU - Masuko, Masayoshi AU - Uchida, Naoyuki AU - Ozawa, Yukiyasu AU - Iwato, Koji AU - Ohashi, Kazuteru AU - Ikegame, Kazuhiro AU - Kim, Sung-Won AU - Tanaka, Masatsugu AU - Eto, Tetsuya AU - Kanda, Yoshinobu AU - Fukuda, Takahiro AU - Atsuta, Yoshiko AU - Yano, Shingo AU - Takami, Akiyoshi T2 - Bone Marrow Transplantation AB - Philadelphia chromosome-positive acute myeloid leukemia (Ph+ AML) confers a dismal prognosis when treated with chemotherapy alone. Data on allogeneic hematopoietic cell transplantation (allo-HCT) outcomes are limited. We retrospectively analyzed 4649 AML patients who received allo-HCT and were in complete remission. Outcomes of Ph+ AML (n = 30), intermediate-risk, and poor-risk AML patients were compared. The 3-year overall survival after allo-HCT was similar in intermediate-risk (62.7%; 95% CI: 61.0–64.3%) and Ph+ AML (73.3%; 95% CI: 51.5–86.4%) groups (P = 0.42); however, it differed significantly between the poor-risk (49.7%; 95% CI: 45.9–53.4%) and Ph+ AML (73.3%; 95% CI: 51.5–86.4%) groups (P = 0.049). Disease-free survival in Ph+ AML patients was comparable to that in intermediate-risk patients but better than that in poor-risk patients. Relapse rates were significantly lower in Ph+ AML patients than in other groups. Non-relapse mortality (NRM) rates were similar among groups. Multivariate analysis showed that Ph+ AML was not a significant predictor of poor prognosis in terms of overall survival, disease-free survival, relapse, and NRM. Our data showed better post-transplant outcomes for Ph+ AML patients than for those with poor-risk AML. Hence, allo-HCT could be a feasible treatment option for Ph+ AML patients. DA - 2020/07/31/ PY - 2020 DO - 10.1038/s41409-020-01011-0 DP - www.nature.com SP - 1 EP - 11 LA - en SN - 1476-5365 UR - https://www.nature.com/articles/s41409-020-01011-0 Y2 - 2020/07/31/17:01:34 ER -