TY - JOUR TI - Comparison of two different rabbit antithymocyte globulin (r-ATG) preparations:Thymocyte r-ATG versus T lymphoblast cell line r-ATG in allogeneic hematopoietic stem cell transplantation for acquired severe aplastic anemia: propensity score-matched analysis AU - Liu, Limin AU - Xu, Guofa AU - Zhang, Yanming AU - Jiao, Wenjing AU - Lei, Meiqing AU - Zhou, Huifen AU - Wang, Qingyuan AU - Qiu, Huiying AU - Tang, Xiaowen AU - Han, Yue AU - Fu, Chengcheng AU - Jin, Zhengming AU - Chen, Suning AU - Sun, Aining AU - Miao, Miao AU - Wu, Depei T2 - Biology of Blood and Marrow Transplantation AB -

Abstract

We retrospectively analyzed the outcomes of 214 severe aplastic anemia (SAA) patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) with rabbit antithymocyte globulin (r-ATG) or ATG-Fresenius (ATG-F). Using propensity score matching, we performed a case-control study comparing 44 and 23 patients in the r-ATG and ATG-F groups, respectively. The median time for myeloid engraftment was 11 vs. 11 days (P = 0.368) and for platelet engraftment was 11 vs. 13 days (P = 0.030) in the r-ATG and ATG-F groups, respectively. The r-ATG group showed a lower incidence of grades III–IV acute graft-versus-host disease (aGVHD) than the ATG-F group (2.27% vs. 17.39%, P = 0.026). Similar outcomes were observed between the r-ATG and ATG-F groups for infection rate (59.09% vs. 56.52%, P = 0.840), grades II–IV aGVHD (20.45% vs. 21.74%, P = 0.948), overall incidence of chronic GVHD (26.83% vs. 22.73%, P = 0.704), moderate–severe chronic GVHD (9.76% vs. 13.64%, P = 0.648), and transplantation-related mortality (11.36% vs. 4.35%, P = 0.614). There was no statistical difference in 5-year overall survival (86.40% vs. 95.7%, P = 0.245), GVHD-free, failure-free survival (77.30% vs. 78.30%, P = 0.986), or health-related quality of life (P ๥ 0.05) between the r-ATG and ATG-F

DA - 2020/08/20/ PY - 2020 DO - 10.1016/j.bbmt.2020.08.020 DP - www.bbmt.org VL - 0 IS - 0 J2 - Biology of Blood and Marrow Transplantation LA - English SN - 1083-8791, 1523-6536 ST - Comparison of two different rabbit antithymocyte globulin (r-ATG) preparations UR - https://www.bbmt.org/article/S1083-8791(20)30512-7/abstract Y2 - 2020/08/24/17:57:52 ER -