TY - JOUR TI - Mesenchymal Stem Cells Derived from Wharton’s Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts AU - Choi, Soon Jin AU - Park, Suk Young AU - Shin, Young Ho AU - Heo, Seung-Ho AU - Kim, Kang-Hyun AU - Lee, Hyo In AU - Kim, Jae Kwang T2 - Tissue Engineering and Regenerative Medicine AB - Schwann cells (SCs) secrete neurotrophic factors and provide structural support and guidance during axonal regeneration. However, nearby nerves may be damaged to obtain primary SCs, and there is a lack of nervous tissue donors. We investigated the potential of Wharton’s Jelly-derived mesenchymal stem cells (WJ-MSCs) in differentiating into Schwann cell-like cells (WJ-SCLCs) as an alternative to SCs. We also examined whether implantation of WJ-SCLCs-laden acellular nerve grafts (ANGs) are effective in inducing functional recovery and nerve regeneration in an animal model of peripheral nerve injury. DA - 2021/01/30/ PY - 2021 DO - 10.1007/s13770-020-00329-6 DP - Springer Link J2 - Tissue Eng Regen Med LA - en SN - 2212-5469 UR - https://doi.org/10.1007/s13770-020-00329-6 Y2 - 2021/02/02/17:46:40 ER -