TY - JOUR TI - Microenvironmental changes induced by placenta-derived mesenchymal stem cells restore ovarian function in ovariectomized rats via activation of the PI3K-FOXO3 pathway AU - Choi, Jong Ho AU - Seok, Jin AU - Lim, Seung Mook AU - Kim, Tae Hee AU - Kim, Gi Jin T2 - Stem Cell Research & Therapy AB - Translational studies have explored the therapeutic potential and feasibility of mesenchymal stem cells (MSCs) in several degenerative diseases; however, mechanistic studies of the function of these cells have been insufficient. As ovarian failure causes anovulation as well as ovarian steroid hormonal imbalances, the specific aims of this study were to analyze the therapeutic role of placenta-derived MSCs (PD-MSCs) in an ovarian failure ovariectomy (OVX) rat model and evaluate whether PD-MSC transplantation (Tx) improved folliculogenesis and oocyte maturation in the injured ovary through PI3K/Akt and FOXO signaling. DA - 2020/11/16/ PY - 2020 DO - 10.1186/s13287-020-02002-0 DP - BioMed Central VL - 11 IS - 1 SP - 486 J2 - Stem Cell Research & Therapy SN - 1757-6512 UR - https://doi.org/10.1186/s13287-020-02002-0 Y2 - 2020/11/26/00:46:19 ER -