TY - JOUR TI - RNA sequencing reveals BMP4 as a basis for the dual-target treatment of diabetic retinopathy AU - Dong, Lijie AU - Zhang, Zhe AU - Liu, Xun AU - Wang, Qiong AU - Hong, Yaru AU - Li, Xiaorong AU - Liu, Juping T2 - Journal of Molecular Medicine AB - Diabetic retinopathy (DR), currently considered as a neurovascular disease, has become the major cause of blindness. More and more scholars believe that DR is no longer just a kind of microvascular disease, but accompanied by retinal neurodegenerative changes. Intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs is a classic treatment for DR; however, anti-VEGF drugs can exacerbate fibrosis and eventually lead to retinal detachment. The aim of this study was to explore the pathogenesis of DR and identified new treatments that can provide dual-target intervention for angiogenesis and fibrosis. DA - 2020/11/14/ PY - 2020 DO - 10.1007/s00109-020-01995-8 DP - Springer Link J2 - J Mol Med LA - en SN - 1432-1440 UR - https://doi.org/10.1007/s00109-020-01995-8 Y2 - 2020/11/17/00:04:00 ER -