TY - JOUR TI - Intestinal multicellular organoids to study colorectal cancer AU - Idris, Musa AU - Alves, Maria M. AU - Hofstra, Robert M. W. AU - Mahe, Maxime M. AU - Melotte, Veerle T2 - Biochimica et Biophysica Acta (BBA) - Reviews on Cancer AB - Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. In this review, we describe both normal and CRC intestinal organoid models and their utility in the cancer research field. Besides highlighting studies that develop epithelial CRC organoid models, i.e. organoids without tumor microenvironment (TME) cellular components, we emphasize on the need for TME in CRC modeling, to help reduce translational disparities in this area. Also, we discuss the utilization of CRC organoids derived from pluripotent stem cells, as well as their potential to be used in cancer research. Finally, limitations and challenges in the current CRC organoids field, are discussed. DA - 2021/12/01/ PY - 2021 DO - 10.1016/j.bbcan.2021.188586 DP - ScienceDirect VL - 1876 IS - 2 SP - 188586 J2 - Biochimica et Biophysica Acta (BBA) - Reviews on Cancer LA - en SN - 0304-419X UR - https://www.sciencedirect.com/science/article/pii/S0304419X21000834 Y2 - 2021/07/08/17:20:46 KW - Colorectal cancer KW - Modeling KW - Organoids KW - Tumor microenvironment ER -