TY - JOUR TI - Ferroptosis in infection, inflammation, and immunity AU - Chen, Xin AU - Kang, Rui AU - Kroemer, Guido AU - Tang, Daolin T2 - Journal of Experimental Medicine AB - Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways). Excessive or deficient ferroptotic cell death is implicated in a growing list of physiological and pathophysiological processes, coupled to a dysregulated immune response. This review focuses on new discoveries related to how ferroptotic cells and their spilled contents shape innate and adaptive immunity in health and disease. Understanding the immunological characteristics and activity of ferroptotic death not only illuminates an intersection between cell death and immunity but may also lead to the development of novel treatment approaches for immunopathological diseases. DA - 2021/05/12/ PY - 2021 DO - 10.1084/jem.20210518 DP - Silverchair VL - 218 IS - e20210518 J2 - Journal of Experimental Medicine SN - 0022-1007 UR - https://doi.org/10.1084/jem.20210518 Y2 - 2021/05/13/17:12:16 ER -