TY - JOUR TI - Berberine inhibits chemotherapy-exacerbated ovarian cancer stem cell-like characteristics and metastasis through GLI1 AU - Zhao, Yawei AU - Yang, Xuehan AU - Zhao, Jingtong AU - Gao, Mohan AU - Zhang, Min AU - Shi, Tongfei AU - Zhang, Fan AU - Zheng, Xiao AU - Pan, Yue AU - Shao, Dan AU - Li, Jing AU - He, Kan AU - Chen, Li T2 - European Journal of Pharmacology AB - Despite the remarkable clinical response in ovarian cancer therapy, the distinctively high metastasis rate is still a barrier to achieve satisfying prognosis. Our study aimed to decipher the role of berberine in inhibiting chemotherapy-exacerbated ovarian cancer metastasis. We found that chemotherapy exacerbated the migration and cancer stem cell (CSC)-like characteristics through transcriptional factor GLI1, which regulated the pluripotency-associated gene BMI1 and the epithelial-mesenchymal transition (EMT) markers Vimentin and Snail. Berberine could not only down-regulate CSC-like characteristics but also reverse EMT and migration through inhibiting chemotherapy-activated GLI1/BMI1 signaling pathway. Together, our study revealed the pivotal role of berberine in overcoming chemotherapy-exacerbated ovarian cancer metastasis, thereby provided a potential adjuvant therapeutic agent in combination with chemotherapeutics to prevent metastasis during ovarian cancer chemotherapy. DA - 2021/03/15/ PY - 2021 DO - 10.1016/j.ejphar.2021.173887 DP - ScienceDirect VL - 895 SP - 173887 J2 - European Journal of Pharmacology LA - en SN - 0014-2999 UR - http://www.sciencedirect.com/science/article/pii/S0014299921000406 Y2 - 2021/02/03/17:22:57 KW - Berberine KW - Cancer stem cell KW - Chemotherapy KW - Migration KW - Ovarian cancer ER -