TY - JOUR TI - Propofol inhibits tumor angiogenesis through targeting VEGF/VEGFR and mTOR/eIF4E signaling AU - Wang, Zhibao AU - Cao, Bo AU - Ji, Peng AU - Yao, Fan T2 - Biochemical and Biophysical Research Communications AB - Propofol, a commonly used intravenous anesthetic in tumor surgery, has recently garnered attention for its anti-cancer activity. We previously demonstrated that propofol inhibits migration and invasion of esophageal squamous cell carcinoma cells. However, the effects of propofol in tumor angiogenesis are inconclusive. The current study investigated the effects of propofol on the biological functions of lung cancer associated endothelial cells (LC-EC) and colon cancer associated endothelial cells (CC-EC) that represent in vitro tumor angiogenesis. We showed that propofol inhibited tubular structure formation of both LC-EC and CC-EC, particularly the early stages of angiogenesis. In addition, propofol inhibited migration, adhesion, proliferation, and survival of tumor associated endothelial cells. Mechanism studies revealed that propofol disrupted tumor angiogenesis microenvironment via suppressing expression and secretion of multiple pro-angiogenic factors by tumor cells. Propofol also inhibited VEGF/VEGFR2-and mTOR/eIF4E-mediated signaling pathways in endothelial cells. Our findings demonstrate the inhibitory effects of propofol on tumor angiogenesis and support the anti-cancer properties of propofol. Our work provides preclinical evidence into the potential mechanisms by which propofol may negatively affect tumor growth and metastasis. DA - 2021/05/28/ PY - 2021 DO - 10.1016/j.bbrc.2021.03.094 DP - ScienceDirect VL - 555 SP - 13 EP - 18 J2 - Biochemical and Biophysical Research Communications LA - en SN - 0006-291X UR - https://www.sciencedirect.com/science/article/pii/S0006291X21004903 Y2 - 2021/04/12/17:14:21 KW - Propofol KW - Tumor angiogenesis KW - VEGF/VEGFR2 KW - mTOR/eIF4E ER -