TY - JOUR TI - Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines AU - Gheytanchi, Elmira AU - Naseri, Marzieh AU - Karimi-Busheri, Feridoun AU - Atyabi, Fatemeh AU - Mirsharif, Ensie Sadat AU - Bozorgmehr, Mahmood AU - Ghods, Roya AU - Madjd, Zahra T2 - Cancer Cell International AB - Relapse and metastasis in colorectal cancer (CRC) are often attributed to cancer stem-like cells (CSCs), as small sub-population of tumor cells with ability of drug resistance. Accordingly, development of appropriate models to investigate CSCs biology and establishment of effective therapeutic strategies is warranted. Hence, we aimed to assess the capability of two widely used and important colorectal cancer cell lines, HT-29 and Caco-2, in generating spheroids and their detailed morphological and molecular characteristics. DA - 2021/04/13/ PY - 2021 DO - 10.1186/s12935-021-01898-9 DP - BioMed Central VL - 21 IS - 1 SP - 204 J2 - Cancer Cell International SN - 1475-2867 UR - https://doi.org/10.1186/s12935-021-01898-9 Y2 - 2021/04/14/16:54:44 KW - Cancer stem cells (CSCs) KW - Colorectal cancer (CRC) KW - Drug resistance KW - Epithelial-to-mesenchymal transition (EMT) KW - Sphere formation ER -