TY - JOUR TI - Lentiviral vector induces high-quality memory T cells via dendritic cells transduction AU - Ku, Min Wen AU - Authié, Pierre AU - Nevo, Fabien AU - Souque, Philippe AU - Bourgine, Maryline AU - Romano, Marta AU - Charneau, Pierre AU - Majlessi, Laleh T2 - Communications Biology AB - We report a lentiviral vector harboring the human β2-microglobulin promoter, with predominant expression in immune cells and minimal proximal enhancers to improve vector safety. This lentiviral vector efficiently transduces major dendritic cell subsets in vivo. With a mycobacterial immunogen, we observed distinct functional signatures and memory phenotype in lentiviral vector- or Adenovirus type 5 (Ad5)-immunized mice, despite comparable antigen-specific CD8+ T cell magnitudes. Compared to Ad5, lentiviral vector immunization resulted in higher multifunctional and IL-2-producing CD8+ T cells. Furthermore, lentiviral vector immunization primed CD8+ T cells towards central memory phenotype, while Ad5 immunization favored effector memory phenotype. Studies using HIV antigens in outbred rats demonstrated additional clear-cut evidence for an immunogenic advantage of lentiviral vector over Ad5. Additionally, lentiviral vector provided enhance therapeutic anti-tumor protection than Ad5. In conclusion, coupling lentiviral vector with β2-microglobulin promoter represents a promising approach to produce long-lasting, high-quality cellular immunity for vaccinal purposes. DA - 2021/06/10/ PY - 2021 DO - 10.1038/s42003-021-02251-6 DP - www.nature.com VL - 4 IS - 1 SP - 1 EP - 16 J2 - Commun Biol LA - en SN - 2399-3642 UR - https://www.nature.com/articles/s42003-021-02251-6 Y2 - 2021/06/10/17:37:15 ER -