TY - JOUR TI - Macrophage migration inhibitory factor facilitates the therapeutic efficacy of mesenchymal stem cells derived exosomes in acute myocardial infarction through upregulating miR-133a-3p AU - Zhu, Wenwu AU - Sun, Ling AU - Zhao, Pengcheng AU - Liu, Yaowu AU - Zhang, Jian AU - Zhang, Yuelin AU - Hong, Yimei AU - Zhu, Yeqian AU - Lu, Yao AU - Zhao, Wei AU - Chen, Xinguang AU - Zhang, Fengxiang T2 - Journal of Nanobiotechnology AB - Exosome transplantation is a promising cell-free therapeutic approach for the treatment of ischemic heart disease. The purpose of this study was to explore whether exosomes derived from Macrophage migration inhibitory factor (MIF) engineered umbilical cord MSCs (ucMSCs) exhibit superior cardioprotective effects in a rat model of AMI and reveal the mechanisms underlying it. DA - 2021/02/27/ PY - 2021 DO - 10.1186/s12951-021-00808-5 DP - BioMed Central VL - 19 IS - 1 SP - 61 J2 - Journal of Nanobiotechnology SN - 1477-3155 UR - https://doi.org/10.1186/s12951-021-00808-5 Y2 - 2021/03/02/16:47:49 KW - Exosomes KW - Macrophage migration inhibitory factor KW - MiR-133a-3p KW - Myocardial infarction KW - UcMSCs ER -