TY - JOUR TI - Hsa_circ_0007456 regulates the natural killer cell-mediated cytotoxicity toward hepatocellular carcinoma via the miR-6852-3p/ICAM-1 axis AU - Shi, Min AU - Li, Zhao-Yun AU - Zhang, Li-Ming AU - Wu, Xiao-Yu AU - Xiang, Shi-Hao AU - Wang, Yu-Gang AU - Zhang, Ya-Qiong T2 - Cell Death & Disease AB - Circular RNAs (circRNAs) is one type of important non-coding RNAs that participate in tumorigenesis and cancer progression. In our previous study, we performed a microarray analysis of circRNAs between the tumor tissues and the adjacent normal tissues of hepatocellular carcinoma (HCC) patients, and found that the circRNA hsa_circ_0007456 is significantly downregulated in the tumor tissues and correlated with the prognosis of HCC. We further investigated the relationship between the expression levels of hsa_circ_0007456 in HCC and the susceptibility of NK cells, and found that the expression levels of hsa_circ_0007456 in HCC cell lines significantly influenced their susceptibility to NK cells. Through a series of screening and validation, we found that hsa_circ_0007456 mainly functioned through sponging miR-6852-3p and regulating the expression of intercellular adhesion molecule-1 (ICAM-1) in HCC. The miR-6852-3p/ICAM-1 axis is essential for the NK cytotoxicity toward HCC mediated by hsa_circ_0007456. In conclusion, we identify here hsa_circ_0007456 as a promising biomarker of HCC, and highlight hsa_circ_0007456/miR-6852-3p/ICAM-1 axis as an important signaling pathway in the process of tumor immune evasion and the tumorigenesis of HCC. DA - 2021/01/18/ PY - 2021 DO - 10.1038/s41419-020-03334-8 DP - www.nature.com VL - 12 IS - 1 SP - 1 EP - 13 LA - en SN - 2041-4889 UR - https://www.nature.com/articles/s41419-020-03334-8 Y2 - 2021/01/18/23:58:37 ER -