TY - JOUR TI - Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling AU - He, Yulin AU - Guo, Xingrong AU - Lan, Tingyu AU - Xia, Jianbo AU - Wang, Jinsong AU - Li, Bei AU - Peng, Chunyan AU - Chen, Yue AU - Hu, Xiang AU - Meng, Zhongji T2 - Stem Cell Research & Therapy AB - Effective treatments for acute-on-chronic liver failure (ACLF) are lacking. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been applied in tissue regeneration and repair, acting through paracrine effects, cell fusion, and actual transdifferentiation. The present study was designed to investigate the therapeutic potential of hUC-MSCs in acute-on-chronic liver injury (ACLI) and ACLF rat models. DA - 2021/07/13/ PY - 2021 DO - 10.1186/s13287-021-02468-6 DP - BioMed Central VL - 12 IS - 1 SP - 396 J2 - Stem Cell Research & Therapy SN - 1757-6512 UR - https://doi.org/10.1186/s13287-021-02468-6 Y2 - 2021/07/14/21:50:40 KW - ACLF KW - Liver fibrosis KW - Liver injury KW - Notch KW - Paracrine KW - Stat1 KW - Stat3 KW - hUC-MSCs ER -