TY - JOUR TI - ZnO/Nanocarbons-Modified Fibrous Scaffolds for Stem Cell-Based Osteogenic Differentiation AU - Xia, Yi AU - Fan, Xin AU - Yang, Hua AU - Li, Ling AU - He, Chao AU - Cheng, Chong AU - Haag, Rainer T2 - Small AB - Currently, mesenchymal stem cells (MSCs)-based therapies for bone regeneration and treatments have gained significant attention in clinical research. Though many chemical and physical cues which influence the osteogenic differentiation of MSCs have been explored, scaffolds combining the benefits of Zn2+ ions and unique nanostructures may become an ideal interface to enhance osteogenic and anti-infective capabilities simultaneously. In this work, motivated by the enormous advantages of Zn-based metal–organic framework-derived nanocarbons, C-ZnO nanocarbons-modified fibrous scaffolds for stem cell-based osteogenic differentiation are constructed. The modified scaffolds show enhanced expression of alkaline phosphatase, bone sialoprotein, vinculin, and a larger cell spreading area. Meanwhile, the caging of ZnO nanoparticles can allow the slow release of Zn2+ ions, which not only activate various signaling pathways to guide osteogenic differentiation but also prevent the potential bacterial infection of implantable scaffolds. Overall, this study may provide new insight for designing stem cell-based nanostructured fibrous scaffolds with simultaneously enhanced osteogenic and anti-infective capabilities. DO - 10.1002/smll.202003010 DP - Wiley Online Library VL - n/a IS - n/a SP - 2003010 LA - en SN - 1613-6829 UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.202003010 Y2 - 2020/08/20/22:47:34 KW - anti-infective surfaces KW - carbon nanomaterials KW - metal–organic frameworks KW - nanostructured fibrous scaffolds KW - osteogenic surfaces KW - stem cells ER -