TY - JOUR TI - PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins AU - Santio, Niina M. AU - Vainio, Veera AU - Hoikkala, Tuuli AU - Mung, Kwan Long AU - Lång, Mirka AU - Vahakoski, Riitta AU - Zdrojewska, Justyna AU - Coffey, Eleanor T. AU - Kremneva, Elena AU - Rainio, Eeva-Marja AU - Koskinen, Päivi J. T2 - Cell Communication and Signaling AB - The PIM family kinases promote cancer cell survival and motility as well as metastatic growth in various types of cancer. We have previously identified several PIM substrates, which support cancer cell migration and invasiveness. However, none of them are known to regulate cellular movements by directly interacting with the actin cytoskeleton. Here we have studied the phosphorylation-dependent effects of PIM1 on actin capping proteins, which bind as heterodimers to the fast-growing actin filament ends and stabilize them. DA - 2020/08/08/ PY - 2020 DO - 10.1186/s12964-020-00618-6 DP - BioMed Central VL - 18 IS - 1 SP - 121 J2 - Cell Communication and Signaling SN - 1478-811X UR - https://doi.org/10.1186/s12964-020-00618-6 Y2 - 2020/08/10/21:24:29 ER -