TY - JOUR TI - Application of mesenchymal stem cell sheet to treatment of ischemic heart disease AU - Chang, Dehua AU - Fan, Taibing AU - Gao, Shuang AU - Jin, Yongqiang AU - Zhang, Mingkui AU - Ono, Minoru T2 - Stem Cell Research & Therapy AB - In recent years, mesenchymal stem cells (MSCs) have been used to improve cardiac function and attenuate adverse ventricular remodeling of the ischemic myocardium through paracrine effects and immunoregulation functions. In combination with cell sheet technology, MSCs could be more easily transplanted to the ischemic area. The long-term retention of MSCs in the affected area was realized and significantly improved the curative effect. In this review, we summarized the research and the applications of MSC sheets to the treatment of ischemic heart tissue. At present, many types of MSCs have been considered as multipotent cells in the treatment of heart failure, such as bone marrow-derived mesenchymal stem cells (BM-MSCs), adipose-derived mesenchymal stem cells (AD-MSCs), umbilical cord-derived mesenchymal stem cells (UC-MSCs), and skeletal myoblasts (SMs). Since UC-MSCs have few human leukocyte antigen-II and major histocompatibility complex class I molecules, and are easy to isolate and culture, UC-MSC sheets have been proposed as a candidate for clinical applications to ischemic heart disease. DA - 2021/07/07/ PY - 2021 DO - 10.1186/s13287-021-02451-1 DP - BioMed Central VL - 12 IS - 1 SP - 384 J2 - Stem Cell Research & Therapy SN - 1757-6512 UR - https://doi.org/10.1186/s13287-021-02451-1 Y2 - 2021/07/12/21:11:32 KW - Cardiac tissue KW - Cell sheet KW - Cell therapy KW - Mesenchymal stem cells ER -