TY - JOUR TI - GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision AU - Wang, Kai AU - Chen, Yuhui AU - Ahn, Sarah AU - Zheng, Min AU - Landoni, Elisa AU - Dotti, Gianpietro AU - Savoldo, Barbara AU - Han, Zongchao T2 - Nature Cancer AB - Retinoblastoma (RB) is a pediatric retinal tumor that overexpresses the ganglioside GD2. Although it is treatable in patients with early diagnosis, patients may lose one or two eyes. We generated GD2-specific chimeric antigen receptor T lymphocytes (GD2.CAR-Ts) and locally delivered them to mice with an in situ grafting RB. We showed that, when used in combination with the local release of interleukin-15 and an injectable hydrogel, GD2.CAR-Ts successfully eliminate RB tumor cells without impairing mouse vision. DA - 2020/10/12/ PY - 2020 DO - 10.1038/s43018-020-00119-y DP - www.nature.com SP - 1 EP - 8 LA - en SN - 2662-1347 UR - https://www.nature.com/articles/s43018-020-00119-y Y2 - 2020/10/13/23:01:16 ER -