TY - JOUR TI - Modeling human neuronal migration deficits in 3D AU - Reiner, Orly AU - Parichha, Arpan AU - Sapir, Tamar T2 - Current Opinion in Neurobiology AB - During the past few decades, we have witnessed an impressive gain in the knowledge regarding the basic mechanisms underlying human neuronal migration disorders by the usage of mouse models. Nevertheless, despite the remarkable conservation both in the genetic encoded information and the developmental processes, there are still numerous important differences between human and mouse. This may explain the vast excitement following the realization that technological breakthroughs enabled generating tissue-like human-based organoids for modeling human neuronal migration diseases. This review will provide a short introduction on human and mouse neuronal migration processes, and highlight human brain organoid models of neuronal migration diseases. DA - 2021/02/01/ PY - 2021 DO - 10.1016/j.conb.2020.09.005 DP - ScienceDirect VL - 66 SP - 30 EP - 36 J2 - Current Opinion in Neurobiology LA - en SN - 0959-4388 UR - http://www.sciencedirect.com/science/article/pii/S0959438820301318 Y2 - 2020/10/20/23:17:32 ER -