TY - JOUR TI - Dialog between skin and its microbiota: Emergence of “Cutaneous Bacterial Endocrinology” AU - Racine, Pierre-Jean AU - Janvier, Xavier AU - Clabaut, Maximilien AU - Catovic, Chloe AU - Souak, Djouhar AU - Boukerb, Amine M. AU - Groboillot, Anne AU - Konto‐Ghiorghi, Yoan AU - Duclairoir‐Poc, Cécile AU - Lesouhaitier, Olivier AU - Orange, Nicole AU - Chevalier, Sylvie AU - Feuilloley, Marc G. J. T2 - Experimental Dermatology AB - Microbial endocrinology is studying the response of microorganisms to hormones and neurohormones and the microbiota production of hormones-like molecules. Until now, it was mainly applied to the gut and revealed that the intestinal microbiota should be considered as a real organ in constant and bilateral interactions with the whole human body. The skin harbors the second most abundant microbiome and contains an abundance of nerve terminals and capillaries, which in addition to keratinocytes, fibroblasts, melanocytes, dendritic cells and endothelial cells, release a huge diversity of hormones and neurohormones. In the present review, we will examine recent experimental data showing that, in skin, molecules such as substance P, calcitonin gene related peptide, natriurietic peptides and catecholamines can directly affect the physiology and virulence of common skin associated bacteria. Conversely, bacteria are able to synthesize and release compounds including histamine, glutamate and γ-aminobutyric acid or peptides showing partial homology with neurohormones such as α-Melanocyte Stimulating Hormone (αMSH). The more surprising is that some viruses can also encode neurohormones mimicking proteins. Taken together, these elements demonstrate that there is also a cutaneous microbial endocrinology and this emerging concept will certainly have important consequences in dermatology. DO - 10.1111/exd.14158 DP - Wiley Online Library VL - n/a IS - n/a LA - en SN - 1600-0625 ST - Dialog between skin and its microbiota UR - https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14158 Y2 - 2020/07/20/20:11:35 KW - Bacterial communication KW - Calcitonin Gene Related Peptide KW - Natriuretic factors - Catecholamines KW - Skin microbiota KW - Substance P ER -