TY - JOUR TI - Improvement of sensory neuron growth and survival via negatively regulating PTEN by miR-21-5p-contained small extracellular vesicles from skin precursor-derived Schwann cells AU - Cong, Meng AU - Shen, Mi AU - Wu, Xia AU - Li, Yan AU - Wang, Liting AU - He, Qianru AU - Shi, Haiyan AU - Ding, Fei T2 - Stem Cell Research & Therapy AB - Patients with peripheral nerve injury (PNI) often suffer from hypoxic ischemic impairments, in particular when combined with vascular damage, causing neuronal dysfunction and death. Increasing attention has been paid on skin precursor-derived Schwann cells (SKP-SCs), and previous study has shown that SKP-SCs could promote sensory recovery after cell therapy for PNI, resembling the effect of naive SCs, and SKP-SC-derived extracellular vesicles (SKP-SC-EVs) are putatively supposed to be promising therapeutic agents for neural regeneration. DA - 2021/01/25/ PY - 2021 DO - 10.1186/s13287-020-02125-4 DP - BioMed Central VL - 12 IS - 1 SP - 80 J2 - Stem Cell Research & Therapy SN - 1757-6512 UR - https://doi.org/10.1186/s13287-020-02125-4 Y2 - 2021/01/28/23:33:29 KW - Extracellular vesicles KW - Growth KW - MicroRNAs KW - PI3K/Akt KW - PTEN KW - Schwann cells KW - Sensory neurons KW - Skin precursors KW - Survival ER -