TY - JOUR TI - Intrapancreatic MSC transplantation facilitates pancreatic islet regeneration AU - Khatri, Rahul AU - Petry, Sebastian Friedrich AU - Linn, Thomas T2 - Stem Cell Research & Therapy AB - Type 1 diabetes mellitus (T1D) is characterized by the autoimmune destruction of the pancreatic β cells. The transplantation of mesenchymal stromal/stem cells (MSC) was reported to rescue the damaged pancreatic niche. However, there is an ongoing discussion on whether direct physical contact between MSC and pancreatic islets results in a superior outcome as opposed to indirect effects of soluble factors released from the MSC entrapped in the lung microvasculature after systemic administration. Hence, MSC were studied in direct contact (DC) and indirect contact (IDC) with murine pancreatic β cell line MIN6-cells damaged by nitrosourea derivative streptozotocin (STZ) in vitro. Further, the protective and antidiabetic outcome of MSC transplantation was evaluated through the intrapancreatic route (IPR) and intravenous route (IVR) in STZ-induced diabetic NMRI nude mice. DA - 2021/02/12/ PY - 2021 DO - 10.1186/s13287-021-02173-4 DP - BioMed Central VL - 12 IS - 1 SP - 121 J2 - Stem Cell Research & Therapy SN - 1757-6512 UR - https://doi.org/10.1186/s13287-021-02173-4 Y2 - 2021/02/16/18:28:04 KW - Adipose-derived mesenchymal stem cells KW - Intrapancreatic route KW - Intravenous route KW - Type 1 diabetes mellitus KW - β cell protection ER -