TY - JOUR TI - Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives AU - Pellerin, Laurence AU - Carrié, Lorry AU - Dufau, Carine AU - Nieto, Laurence AU - Ségui, Bruno AU - Levade, Thierry AU - Riond, Joëlle AU - Andrieu-Abadie, Nathalie T2 - Cancers AB - Metabolic reprogramming contributes to the pathogenesis and heterogeneity of melanoma. It is driven both by oncogenic events and the constraints imposed by a nutrient- and oxygen-scarce microenvironment. Among the most prominent metabolic reprogramming features is an increased rate of lipid synthesis. Lipids serve as a source of energy and form the structural foundation of all membranes, but have also emerged as mediators that not only impact classical oncogenic signaling pathways, but also contribute to melanoma progression. Various alterations in fatty acid metabolism have been reported and can contribute to melanoma cell aggressiveness. Elevated expression of the key lipogenic fatty acid synthase is associated with tumor cell invasion and poor prognosis. Fatty acid uptake from the surrounding microenvironment, fatty acid β-oxidation and storage also appear to play an essential role in tumor cell migration. The aim of this review is (i) to focus on the major alterations affecting lipid storage organelles and lipid metabolism. A particular attention has been paid to glycerophospholipids, sphingolipids, sterols and eicosanoids, (ii) to discuss how these metabolic dysregulations contribute to the phenotype plasticity of melanoma cells and/or melanoma aggressiveness, and (iii) to highlight therapeutic approaches targeting lipid metabolism that could be applicable for melanoma treatment. DA - 2020/11// PY - 2020 DO - 10.3390/cancers12113147 DP - www.mdpi.com VL - 12 IS - 11 SP - 3147 LA - en ST - Lipid metabolic Reprogramming UR - https://www.mdpi.com/2072-6694/12/11/3147 Y2 - 2020/10/30/19:17:18 KW - cancer KW - cholesterol KW - eicosanoid KW - fatty acid KW - glycerophospholipid KW - lipid droplet KW - metastasis KW - obesity KW - phenotypic switch KW - pseudo-EMT KW - sphingolipid ER -