TY - JOUR TI - Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling AU - Wang, Fengjiao AU - Wang, Lai AU - Qu, Chao AU - Chen, Lianyu AU - Geng, Yawen AU - Cheng, Chienshan AU - Yu, Shulin AU - Wang, Dan AU - Yang, Lina AU - Meng, Zhiqiang AU - Chen, Zhen T2 - BMC Cancer AB - Kaempferol, a natural flavonoid, exhibits anticancer properties by scavenging reactive oxygen species (ROS). However, increasing evidence has demonstrated that, under certain conditions, kaempferol can inhibit tumor growth by upregulating ROS levels. In this study, we aimed to investigate whether kaempferol effectively suppresses pancreatic cancer through upregulation of ROS, and to explore the underlying molecular mechanism. DA - 2021/04/12/ PY - 2021 DO - 10.1186/s12885-021-08158-z DP - BioMed Central VL - 21 IS - 1 SP - 396 J2 - BMC Cancer SN - 1471-2407 UR - https://doi.org/10.1186/s12885-021-08158-z Y2 - 2021/04/16/17:40:26 KW - Apoptosis KW - Biomarker KW - Kaempferol KW - Pancreatic cancer KW - ROS KW - Tissue transglutaminase ER -