NewslettersPancreatic Cell News NNK from Tobacco Smoking Enhances Pancreatic Cancer Cell Stemness and Chemoresistance by Creating a β2AR-Akt Feedback Loop That Activates Autophagy By Bob - May 24, 2022 0 The authors found that 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) promoted stemness and gemcitabine resistance in pancreatic cancer cell lines. [Molecular Oncology] AbstractFull Article