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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Stem Cell Therapies for Diabetes
[Nature Medicine] Investigators critically review the scientific advances, the clinical trials, and the various regulatory considerations that will need to be overcome for human stem cell-derived pancreatic islet-like cells to become the next cell therapy breakthrough for diabetes treatment.
ZMYND8 Promotes the Warburg Effect and Tumorigenesis through C-Myc Activation in Pancreatic Cancer
[Oncogene] The authors employed an epigenetic siRNA library to identify a crucial regulator, ZMYND8, which is involved in glycolysis in pancreatic cancer cells.
ChemPerturb-Seq Screen Identifies a Small Molecule Cocktail Enhancing Human Beta Cell Survival after Subcutaneous Transplantation
[Cell Stem Cell] The authors combined a chemical screen with scRNA-seq to perform Chemical Perturb-seq (ChemPerturb-seq), enabling a systematic analysis of the molecular changes of human beta cells upon individual small molecule treatments.
NGN3 Oscillatory Expression Controls the Timing of Human Pancreatic Endocrine Differentiation
[Developmental Cell] Scientists investigated the dynamics and decoding of NEUROGENIN3 (NGN3), a transcription factor critical for pancreatic endocrine development.
Single-Cell Lipidomics by LC-MS Interlaboratory Study Reveals the Impact of X-Ray Irradiation on a Pancreatic Cancer Cell Line and Its Bystanders
[Analytical Chemistry] Researchers presented a novel workflow to enable interlaboratory studies, comprising live-cell imaging and single-cell isolation, followed by freeze-drying, international shipping, reconstitution, and untargeted lipidomics analysis.
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
[New England Journal of Medicine] In this Phase III, double-blind, placebo-controlled trial, we randomly assigned participants in a 1:1:1:1 ratio to receive orforglipron at one of three doses or placebo once daily for 40 weeks.
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
[New England Journal of Medicine] Investigators conducted a Phase I–II study of zimislecel in persons with type 1 diabetes. In part A, participants received a half dose of zimislecel as a single infusion into the portal vein, with an option for a second half dose within two years. In parts B and C, participants received a full dose of zimislecel as a single infusion.
Glucose Metabolism and Regulation in Establishing Human Stem Cell-Derived β Cell Maturation
[Cell Reports] Scientists summarize the updated understanding of glucose metabolism in mature β and stem cell-derived β (SC-β) cells, highlighting a potential metabolic defect underlying SC-β immaturity.
Amplia Receives US Ethics Clearance For Pancreatic Cancer Trial
[Amplia Therapeutics] Amplia has received US ethics approval to initiate a Phase II clinical trial of narmafotinib in combination with FOLFIRINOX chemotherapy for advanced pancreatic cancer patients.
A First-in-Class EGFR-Directed KRAS G12V Selective Inhibitor
[Cancer Cell] Investigators demonstrated that an EGFR-directed RNAi molecule is highly selective for KRASG12V and exhibits improved therapeutic activity over pan-KRAS targeting, including enhanced inhibition of several cancer hallmarks.
Identification of KANK1 As a Tumor Suppressor Gene in Pancreatic Ductal Adenocarcinoma.
[Biochemical and biophysical research communications] Scientists identified KANK1 as a novel tumor suppressor gene in PDAC through an integrated mRNA-protein abundance correlation analysis.
Chemical Synthesis Uncovers the Significant Impact of Natural Glycosylation on Islet Amyloid Polypeptide Aggregation.
[Science Advances] The authors investigated the natural glycosylation of islet amyloid polypeptide, a peptide with therapeutic potential for type 2 diabetes but problematic aggregation.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
