Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

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QP6126, an Orally Bioavailable QPCTL Inhibitor, with Anti-Tumor Activity in Melanoma Tumor Model

September 14, 2026

[International Immunopharmacology] Scientists reported the discovery of QP6126, a small-molecule glutaminyl-peptide cyclotransferase-like protein (QPCTL) inhibitor. QP6126 ablates the pGlu-CD47 modification, thereby abolishing CD47-SIRPα interaction, and sensitizing melanoma cells to macrophage-mediated phagocytosis.

Powering Skin Repair: Piezoelectric Biomaterials-Driven Wound Healing

September 14, 2026

[Advanced Materials] The authors provide an overview of piezoelectric biomaterials for skin wound healing and examine the physiological and biochemical roles of the naturally occurring electric fields in healthy skin and injured skin.

The Skin-Specific Long Non-Coding RNA TEDAR Orchestrates Late Epidermal Differentiation via an ERK-KLF4 Cytoplasmic Regulatory Axis

September 14, 2026

[Cell Death & Disease] Using transcriptome analysis of more than 15,000 RNA-seq samples across 54 human tissues, scientists identified terminal epidermal differentiation-associated RNA (TEDAR), a highly skin-enriched lncRNA.

ALKBH5 Acts As a Regulator of Hair Follicle Telogen-to-Anagen Transition in Mice

September 14, 2026

[Communications Biology] Investigators showed that Alkbh5 expression is downregulated during late telogen, and its deletion promotes hair follicle stem cell activation and proliferation, accelerating the telogen–anagen transition in mice.

Type 3 Inflammation-Specific Keratinocyte Glutaminolysis Promotes Skin Inflammation

September 14, 2026

[JCI Insight] Researchers identified GLS1-mediated glutaminolysis as a metabolic program preferentially induced in keratinocytes under type 3 inflammatory conditions. Integrated transcriptomic, metabolomic, genetic, and functional analyses showed that IL-17A induced GLS1 expression and glutaminolysis in keratinocytes.

α-Ketoglutarate Accelerates Cutaneous Wound Healing through Modulating the Epithelial-Fibroblast Niche

September 14, 2026

[JCI Insight] Investigators employed multiomics profiling of clinical samples to investigate metabolic alterations during wound healing. They developed a transdermal microneedle platform based on gelatin methacryloyl for localized αKG delivery, further accelerating tissue repair.

Lavender Essential Oil Coordinates Epidermal GABA Shunt and Nucleotide Turnover to Rescue Cortisol-Induced Stress Damage

September 14, 2026

[Scientific Reports] Researchers established an epidermal stress model was established using cortisol-stimulated human keratinocytes to systematically evaluate the cytoprotective effects of Taikong Blue lavender essential oil .

Immunocore Announces Achievement of Target Enrollment in Registrational TEBE-AM Trial with KIMMTRAK® (Tebentafusp) in Previously Treated Advanced Melanoma

September 14, 2026

[Immunocore ] Immunocore announced the achievement of target patient enrollment in the TEBE-AM clinical trial, a randomized, registrational Phase III clinical trial evaluating KIMMTRAK as monotherapy and in combination with pembrolizumab for the treatment of HLA-A*02:01-positive patients with advanced melanoma.

Medicus Pharma Publishes Abridged Final Phase II SkinJect® Clinical Study Report (CSR) Results Identifying 200 µg D-MNA Patch as the Lead Development Dose

September 11, 2026

[Medicus Pharma] Medicus Pharma announced that an abridged Clinical Study Report for SKNJCT-003 has been posted on ClinicalTrials.gov, providing public access to the clinical findings from the completed Phase II study. The study evaluated two dose levels of SkinJect® compared with a device-only microneedle comparator.

Fatty Acid Oxidation Fuels Mitochondrial Respiration to Drive Epidermal Stem Cell Fate and Differentiation

August 31, 2026

[Nature Communications] Researchers revealed that early mitochondrial reprogramming, characterized by the activation of oxidative phosphorylation, is a determinant of differentiation initiation.

SNHG26 Orchestrates Pro-Fibrotic Fibroblast Maintenance via PTBP1-Mediated Alternative Polyadenylation of AKT3 in Dermal Fibrosis

August 31, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified a previously unrecognized RNA-based mechanism that maintains pathogenic fibroblast states during skin fibrosis.

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids-Containing Biopatch Enables Functional Skin Regeneration

August 31, 2026

[Advanced Healthcare Materials] Investigators presented a 3D embedded bioprinting strategy for engineering vascularized biopatches through the precise integration of prevascularized multicellular spheroids within a skin-derived decellularized extracellular matrix bioink.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.