Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

Three Stepwise pH Progressions in Stratum Corneum for Homeostatic Maintenance of the Skin

[Nature Communications] Researchers used intravital pH imaging at single-corneocyte resolution to demonstrate that corneocytes undergo differentiation to develop three distinct zones in the stratum corneum, each with a distinct pH value.

TASL Mediates Keratinocyte Differentiation by Regulating Intracellular Calcium Levels and Lysosomal Function

[Scientific Reports] Scientists discovered that TLR adaptor interacting with solute carrier family 15 member 4 on the lysosome (TASL) deficiency hindered the proliferation and migration of keratinocytes by inducing G1/S cell cycle arrest.

MLKL, a New Actor of UVB-Induced Apoptosis in Human Diploid Dermal Fibroblasts

[Cell Death Discovery] Investigators evaluated the implication of receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) in ultraviolet radiation (UV) B-induced cell death in human diploid dermal fibroblasts, and reported that RIPK3 and MLKL played opposite roles in UVB-induced cell death, in a necroptosis independent pathway.

Dermal Dive: An Overview of Cutaneous Wounding Techniques in Zebrafish

[Journal Of Investigative Dermatology] Scientists review some of the techniques that have been developed for eliciting cutaneous wounds in the zebrafish, including an economical method they recently developed using a rotary tool that generates consistent and reproducible full-thickness wounds.

A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat Following BRAF and MEK Inhibitors in BRAFV600 mutated Melanoma

[Clinical Cancer Research] Scientists assessed the anti-tumor activity of sequential treatment with vorinostat following BRAF and MEK inhibitors (BRAFi/MEKi) in patients with BRAFV600 melanoma who progressed after initial response to BRAFi/MEKi.

H2A.Z Chaperones Converge on E2F Target Genes for Melanoma Cell Proliferation

[Genes & Development] Researchers showed that individual subunit depletion of SRCAP, P400, and VPS72 resulted in not only the loss of H2A.Z deposition into chromatin but also a reduction of H4 acetylation in melanoma cells.

Twist2 Contributes to Skin Regeneration and Hair Follicle Formation in Mouse Fetuses

[Scientific Reports] Scientists elucidated Twist2 expression and its role in fetal wound healing. Mouse fetuses were surgically wounded, and Twist2 expression in tissue samples from these fetuses were evaluated via in situ hybridization, immunohistochemistry, and reverse transcription-quantitative polymerase chain reaction.

circCDK13-Loaded Small Extracellular Vesicles Accelerate Healing in Preclinical Diabetic Wound Models

[Nature Communications] Scientists demonstrated that circCDK13 could stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.

Recycled Melanoma-Secreted Melanosomes Regulate Tumor-Associated Macrophage Diversification

[EMBO Journal] Scientists reported that melanoma-secreted melanosomes passaged through epidermal keratinocytes or dermal fibroblasts could be further engulfed by resident macrophages, which led to macrophage polarization into pro-tumor or pro-immune cell infiltration phenotypes.

Improvement of Skin Wound Healing by Giant Salamander Skin Mucus Gel Wrapped with Bone Marrow Mesenchymal Stem Cells via Affecting Integrin Family Molecules

[Aging] Giant salamander skin mucus gel dressing wrapped with bone marrow mesenchymal stem cells was prepared and validated, and skin wound injury of rabbit and mouse models were established.

A Keratinocyte-Adipocyte Signaling Loop is Reprogrammed by Loss of BTG3 to Augment Skin Carcinogenesis

[Cell Death & Differentiation] Scientists demonstrated that BTG3 levels were downregulated in basal cell carcinoma and squamous cell carcinoma compared to normal skin tissue, and Btg3 knockout in mice augmented the development of papilloma in a mouse model of skin carcinogenesis.

Identification and Characterization of a New Potent Inhibitor Targeting CtBP1/BARS in Melanoma Cells

[Journal Of Experimental & Clinical Cancer Research] Researchers identified a potent and selective inhibitor of C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate (CtBP1/BARS) active in cellular and melanoma animal models.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.