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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Wnt10b Regulation of Hair Follicle Development, Regeneration, and Skin Diseases
[Stem Cell Reviews and Reports] The authors review the role of Wnt10b signaling in hair growth and regeneration. During embryonic development, Wnt10b promotes hair morphogenesis by inducing the formation of dermal papilla.
NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma
[Cancer Research] Researchers utilized patient-derived short-term cultures and multiomics approaches to identify molecular features that could inform the development of therapies for patients with neurofibromin 1 (NF1) mutant melanoma.
RNase 7 and Th Cytokines Synergistically Increase the Secretion of Interleukin-6 from Keratinocytes
[Scientific Reports] Investigators performed mRNA microarray analysis to study the influence of R7 on gene expression in human keratinocytes. R7 induced several genes encoding proteins potentially involved in skin integrity and inflammation, including IL-24.
Targeting GRPR for Sex Hormone-Dependent Cancer after Loss of E-Cadherin
[Nature] In a mouse model of melanoma, researchers discovered an estrogen-sensitizing pathway connecting E-cadherin, β-catenin, estroogen receptor-α and GRPR that promotes melanoma aggressiveness in women.
Hair Follicle-Derived Melanocyte Transplant As a Promising Treatment Strategy for Vitiligo
[Stem Cell Research & Therapy] Researchers developed a method to isolate and culture hair follicle-derived melanocytes. They identified melanocytes at the cellular, protein, and gene levels and established a mouse model of vitiligo using the melanoma/T regulatory cell exhaustion induction method.
Adjuvant Cemiplimab or Placebo in High-Risk Cutaneous Squamous-Cell Carcinoma
[New England Journal of Medicine] Adjuvant cemiplimab therapy led to longer disease-free survival than placebo among patients at high risk for recurrence of cutaneous squamous-cell carcinoma.
Inhibition of Histone Deacetylases 3 Attenuates Imiquimod-Induced Psoriatic Dermatitis via Targeting cGAS-STING Signaling in Keratinocytes
[Journal of Translational Medicine] Scientists analyzed the role of histone deacetylase 3 (HDAC3) in IMQ-induced psoriasis-like inflammation in mice and in vitro psoriasis models.
SOX10, MITF, and microRNAs: Decoding Their Interplay in Regulating Melanoma Plasticity
[International Journal of Cancer] The authors review and discuss the intricate interplay between SOX10 and miRNAs in melanoma biology including melanogenesis, phenotype switch, and therapy resistance.
Recludix Pharma Advances First-in-Class Oral STAT6 Inhibitor REX-8756 for Inflammatory Diseases, Including Atopic Dermatitis
[Recludix Pharma (Dermatology Times)] Recludix Pharma announced the nomination of its lead development candidate, REX-8756, an oral, reversible, and highly selective STAT6 inhibitor designed to address a wide range of type 2 inflammatory diseases, including atopic dermatitis.
Epigenetic Regulation in Vitiligo: Mechanisms, Challenges, and Therapeutic Opportunities
[Current Opinion In Immunology] The authors explore vitiligo and its pathogenesis, emphasizing the role of epigenetic mechanisms such as DNA methylation, histone modification, noncoding RNAs, chromatin remodeling, and 3D genome regulation.
PIEZO1-Mediated Calcium Signaling Reinforces Mechanical Properties of Hair Follicle Stem Cells to Promote Quiescence
[Science Advances] Investigators showed that hair follicle stem cells sense mechanical forces through cell adhesion and maintain quiescence in a PIEZO1-dependent mechanism.
Butyrate Receptor HCAR2/GPR109A Controls Imiquimod-Induced Psoriasis-Like Skin Inflammation
[The Journal of Immunology] Human and mouse RNA sequencing public datasets reveal elevated HCAR2 gene expression in psoriatic as compared with healthy skin, both in keratinocytes and myeloid cells.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
