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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Bio-Techne’s Simple Westernâ„¢ Technology Utilized in Recent FDA Approval of ZEVASKYNâ„¢ Cell-Based Gene Therapy
[Bio-Techne] Bio-Techne announced that its Simple Westernâ„¢ Technology played a key role in supporting the FDA approval of ZEVASKYNâ„¢, a novel cell-based gene therapy for patients with recessive dystrophic epidermolysis bullosa.
Establishment and Validation of a C57BL/6J Mouse Model for Melasma
[Cell Proliferation] Researchers established a melasma-like model in C57BL/6J mice. Histopathological analysis revealed an accumulation of melanin granules in the epidermis and superficial dermis, elevated levels of tyrosinase in both skin and plasma, systemic oxidative stress imbalance, and reduced autophagic activity in the lesional skin.
Frontiers in the Physiology of Male Pattern Androgenetic Alopecia: Beyond the Androgen Horizon
[Physiological Reviews] The authors describe male pattern androgenetic alopecia (mpAGA) as a physiological phenomenon in which defined hair follicle populations in developmentally preprogrammed scalp skin regions undergo a dramatic, but reversible (mini-)organ transformation in genetically predisposed individuals.
LINC00622 Transcriptionally Promotes RRAGD to Repress mTORC1-Modulated Autophagic Cell Death by Associating with BTF3 in Cutaneous Melanoma
[Cell Death & Disease] Researchers reported a novel long noncoding RNA, LINC00622, which modulates mTORC1-regulated autophagy in cutaneous melanoma.
Somatic Mutations in IRE1α Regulate Keratinocyte Migration and Survival by Differentially Activating Rho GTPases
[Journal of Cell Science] Scientists generated immortalized primary mouse keratinocytes inducibly expressing multiple engineered and cancer-associated mutations, including those present in non-melanoma skin cancers.
Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C
[Advanced Science] Scientists generated reconstituted hair-bearing skin using skin organoids derived from dissociated epidermal cells, dermal cells, and melanocyte progenitors.
Human Skin Models in Biophotonics: Materials, Methods, and Applications
[Advanced Healthcare Materials] The authors present the fundamental optical properties of human skin and outline the principles and materials used to replicate these properties, including absorbers, scatterers, and matrix materials
Rutin Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions by Inhibiting Oxidative Stress Injury and the Inflammatory Response in Mice via the Keap1/Nrf2 Signaling Pathway
[Scientific Reports] To investigate the protective effects of rutin in imiquimod (IMQ)-induced psoriasis model mice and its underlying molecular mechanism, IMQ was applied to mice to induce inflammatory skin that phenotypically mimics psoriasis.
Direct Lineage Reprogramming of Fibroblasts into Functional Keratinocyte-Like Cells via BMI1 and FGFR2b for Diabetic Wound Repair
[Stem Cell Reviews and Reports] Researchers established a novel reprogramming approach using a combination of two factors, BMI1 and FGFR2b, to induce fibroblast-to-keratinocyte-like cells conversion in vitro and delivered via adeno-associated virus 9 in vivo.
Oxyresveratrol Suppressed Melanogenesis, Dendrite Formation, and Melanosome Transport in Melanocytes via Regulation of the MC1R/cAMP/MITF Pathway
[Scientific Reports] The effects and mechanisms of oxyresveratrol on melanogenesis, dendrite formation, and melanosome transport were investigated.
CFAP100 Couples Microtubule Glutamylation to Spindle Pole Integrity in Keratinocytes to Promote Epidermal Development
[Nature Communications] Researchers demonstrated an essential role for cilia and flagella associated protein 100 (CFAP100) in keratinocyte division.
Adhesin Als4112 Promotes Candida auris Skin Colonization through Interactions with Keratinocytes and Extracellular Matrix Proteins
[Nature Communications] The authors showed that a C. auris conserved adhesin, Als4112, is required for skin colonization via keratinocyte attachment and direct interactions with host extracellular matrix proteins, especially basement membrane proteins such as laminin.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
