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Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
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Same Mutation, Different Fates: The Yin-Yang of BRAF-Driven Therapeutic Responses in Melanoma and Colorectal Cancer
[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors dissect the “yin-yang” of BRAF as a therapeutic vulnerability in in melanoma and colorectal cancer and underscore the critical importance of tumor-specific context in precision oncology.
Gas Plasma-Induced Bacterial PAMP Release Promotes Skin Cancer Cell Death
[Cell Death & Disease] Researchers elucidated gas plasma-induced bacterial pathogen-associated molecular patterns (PAMP) release and their combination with direct gas plasma exposure in skin cancer cells in vitro.
The Syntenic Long Non-Coding RNA DANCR Is an Essential Regulator of Zebrafish Development and a Human Melanoma Oncogene
[PLoS Genetics] Scientists identified melanoma-associated lncRNAs predicted to be components of the MITF gene regulatory network in human melanoma that have positionally equivalent transcripts in zebrafish.
Exploiting Metabolic Adaptations to Overcome Dabrafenib Treatment Resistance in Melanoma Cells
[Molecular Oncology] The authors dissected signaling and mitochondrial alterations that characterize the transition from BRAF-specific inhibitors responsiveness to resistance in A375 melanoma cells.
Pathogenesis of Vitiligo: Integrating Immune and Non-Immune Cell Crosstalk
[Academic Radiology] The pathogenesis of vitiligo is centrally mediated by cytotoxic CD8+ T cells specific for melanocyte antigens and their production of IFN-γ. The involvement of other immune cells, such as resident memory T cells and regulatory T cells, innate immune cells,and non-immune cells including keratinocytes and fibroblasts have also garnered attention.
A Selective RPL15 PROTAC Degrader Enhances Anti-PD-1 Immunotherapy in a Murine Melanoma Tumor Model
[Oncogene] RPL15-knockdown B16-F10 melanoma tumors were sensitized to anti-PD-1 antibody, suggesting that RPL15 inhibition may have the potential to improve immune checkpoint inhibitor efficacy.
CD206+CD14- Skin-Resident Macrophages and DC-T Cell Clusters Are Spatial Features Characterizing Nonrelapsing Cutaneous Squamous Cell Carcinoma
[Cancer Immunology Research] Researchers used high-dimensional imaging mass cytometry and a 39-antibody panel to define the immune landscape of 20 primary cutaneous squamous cell carcinomas (cSCC) with distinct clinical outcomes, four relapsing cSCC, and their perilesional skins.
ATAD2 Drives Melanoma Growth and Progression and Inhibits Ferroptosis
[EMBO Reports] Scientists showed that ATAD2 inhibition activates both distinct and common tumor-suppressive pathways in BRAF and NRAS mutant melanoma.
Kymera Therapeutics Announces First Patient Dosed in BROADEN2 Phase 2b Atopic Dermatitis Clinical Trial of KT-621, a First-in-Class, Oral STAT6 Degrader
[Kymera Therapeutics, Inc.] Kymera Therapeutics, Inc. announced that it recently initiated dosing in its BROADEN2 Phase IIb clinical trial evaluating KT-621, an oral, highly selective, potent degrader of STAT6, in patients with moderate to severe atopic dermatitis.
Aloesin Alleviates Imiquimod-Induced Psoriasis in Dermal Layers through Inhibition of Interleukins and NF-κB Signaling Pathways
[Scientific Reports] Scientists evaluated the impact of aloesin, an aromatic chromone found in Aloe vera, on psoriasis using an imiquimod-induced psoriasis model in mice.
TRIM63/IRF-8 Axis Promotes Tumor Progression and Immunosuppression of Melanoma with BRAF Mutation
[Cell Death & Disease] Scientists demonstrated that TRIM63 exhibits overexpression in melanoma cells and exerts its full oncogenic potential upon activation of the MAPK signaling pathway. Mechanistically, BRAF mutation induces ERK1/2-mediated phosphorylation of TRIM63 at serine 69.
A Novel FGF2-Targeted Inhibitor (N-Trans-Feruloyloctopamine) Suppresses UVB-Induced Skin Damage and Hyperpigmentation
[Advanced Healthcare Materials] The authors explored fibroblast growth factor 2's (FGF2) role in UVB-induced skin damage and identifies N-trans-feruloyloctopamine as a novel FGF2 inhibitor.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
