Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

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Rubedo Life Sciences Announces Positive Preliminary Phase I Clinical Trial Results for Lead Drug Candidate RLS-1496 in Patients with Plaque Psoriasis, Atopic Dermatitis, and...

March 30, 2026

[Rubedo Life Sciences, Inc. (Business Wire)] Rubedo Life Sciences, Inc., announced preliminary results from a single-center, ascending-dose, randomized, double-blind, vehicle-controlled trial in patients with plaque psoriasis, atopic dermatitis, and skin aging.

Hyperinnervation Inhibits Organ-Level Regeneration in Mammalian Skin

March 30, 2026

[Cell] Scientists showed that late embryonic full-thickness skin injuries heal by regenerating epithelial, mesenchymal, neuronal, and vascular tissues with proper connectivity.

Smad7-Based Biologic Targeting Epidermis and Stroma Promotes Healing of Diabetic Wounds in Mice and Pigs

March 30, 2026

[Nature Communications] Researchers revealed that keratinocytes and neutrophils are the two major cell types targeted by Tat-PYC-Smad7 to promote diabetic wound healing, providing insight into mechanisms of diabetic wound healing defects targetable by Smad7-based therapy.

Mitochondrial DNA Release via VDAC1 in Keratinocytes: A Key Driver of Innate Immunity and Vitiligo Pathogenesis

March 30, 2026

[Cell Death & Disease] Scientists identifed mitochondrial DNA release as a pivotal event linking oxidative stress to immune activation in keratinocytes. They demonstrated that hydrogen peroxide induces a sequential mitochondrial membrane remodeling process.

GPER1 Reduces Skin Inflammation by Inhibiting Keratinocyte Proliferation

March 30, 2026

[Cell Death Discovery] Investigators showed that G protein-coupled estrogen receptor 1 (GPER1) signaling is downregulated in lesional skin of psoriasis patients and negatively correlates with both inflammation markers and keratinocyte proliferation.

Effect of pH on Niacinamide Skin Permeation

March 30, 2026

[Scientific Reports] Researchers investigated how donor phase pH modulates niacinamide skin permeation and how these effects relate to pH induced changes in stratum corneum electrical properties.

ERCC6L Promotes Cutaneous Melanoma Progression via PLK1-Mediated Aerobic Glycolysis: Mechanisms and Therapeutic Implications

March 30, 2026

[Life Sciences] The authors elucidated the oncogenic role and mechanistic basis of ERCC6L in cutaneous melanoma, focusing on its impact on tumor metabolism and progression.

KLS-3021: Innovative Oncolytic Virotherapy for the Treatment of Advanced Primary and Metastatic Cutaneous Squamous Cell Carcinoma

March 30, 2026

[Molecular Therapy Oncology] Researchers investigated the potential of KLS-3021, a recombinant oncolytic vaccinia virus encoding hyaluronidase, interleukin-12, and soluble programmed cell death 1 fused to an Fc domain. KLS-3021 exhibited tumor-selective cytotoxicity and robust replication in cutaneous squamous cell carcinoma cell lines while sparing normal keratinocytes.

Carbon Dots-Based Nanomaterials for Chronic Wound Healing: From Multifunctional Mechanisms to Smart Dressings and Tissue Regeneration

March 30, 2026

[Advanced Healthcare Materials] Investigators present a comprehensive overview of recent advances in carbon dots-based nanomaterials for chronic wound repair under a framework from fundamental principles to translational applications.

p63 in Skin Homeostasis and Disease: Molecular Mechanisms and Therapeutic Potentials

March 30, 2026

[Cell Death Discovery] Scientists systematically examine the molecular mechanisms and cellular functions of p63 in cutaneous biology, with particular emphasis on its dual roles in maintaining skin integrity and contributing to disease pathogenesis.

Hydrogel-Extracellular Vesicle Engineering Delivery System: A Promising Therapeutic Strategy for Wound Healing

March 16, 2026

[Journal of Nanobiotechnology] Investigators systematically synthesizes contemporary advances in extracellular vesicles hydrogel systems for chronic wound therapy.

US FDA Approves Bristol Myers Squibb’s Sotyktu® (deucravacitinib) for the Treatment of Adults with Active Psoriatic Arthritis

March 16, 2026

[Bristol Myers Squibb (Business Wire)] Bristol Myers Squibb announced that the US FDA has approved Sotyktu^® (deucravacitinib) for the treatment of adults with active psoriatic arthritis.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.