Towards Maturation of Human Otic Hair Cell-Like Cells in Pluripotent Stem Cell–Derived Organoid Transplants

Investigators devised a strategy to enhance maturation of otic progenitor cells toward human hair cell–like cells by assembling 3D otic organoids that contain human pluripotent stem cell-derived otic cells, endothelial cells, and mesenchymal stem cells.
[Cell and Tissue Research]
Moeinvaziri, F., Shojaei, A., Haghparast, N., Yakhkeshi, S., Nemati, S., Hassani, S.-N., & Baharvand, H. (2021). Towards maturation of human otic hair cell–like cells in pluripotent stem cell–derived organoid transplants. Cell and Tissue Research. https://doi.org/10.1007/s00441-021-03510-y Cite
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Rapid Signaling Reactivation after Targeted BRAF Inhibition Predicts the Proliferation of Individual Melanoma Cells from an Isogenic Population

By tracking cell lineages over multiple days, researchers established that these cells indeed proliferated more than neighboring cells, thus establishing that rapid signaling reactivation predicts long-term vemurafenib resistance.
[Scientific Reports]
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Large Scale Clinical Exome Sequencing Uncovers the Scope and Severity of Skin Disorders Associated with MC1R Genetic Variants

Genetic variation in MC1R is a main determinant of red hair color phenotype and confers susceptibility to skin disorders. Scientists assessed the effects and function of MC1R variants identified in our clinical cohort of 135,947 participants with available exome sequencing using phenome-wide association scan
[Genetics in Medicine]
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Staphylococcus aureus Uses the ArlRS and MgrA Cascade to Regulate Immune Evasion during Skin Infection

Through a combination of in vitro assays, mouse models, and intravital imaging, scientists found that S. aureus immune evasion in skin was controlled by a cascade composed of the ArlRS two-component regulatory system and its downstream effector, MgrA.
[Cell Reports]
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Fermitin Family Member 2 Promotes Melanoma Progression by Enhancing the Binding of P-α-Pix to Rac1 to Activate the MAPK Pathway

Researchers identified fermitin family member 2 as a potential target in A375 cell line by siRNA library screening. They also validated the tumor suppressive role of kindlin-2 was validated in vitro and in vivo.
[Oncogene]
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SIRT7 Gene Knockout Using CRISPR/Cas9 System Enhances Melanin Production in the Melanoma Cells

SIRT7 has evoked an interest in the study of hair follicle stem cells, but its role in melanin synthesis remains unclear. Investigators developed SIRT7 gene knock out melanoma cells using the CRISPR/Cas9 system.
[Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease]
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Bio-Engineering a Prevascularized Human Tri-layered Skin Substitute Containing a Hypodermis

Severe injuries to skin including hypodermis require full-thickness skin replacement. Researchers bio-engineered a tri-layered human skin substitute containing the epidermis, dermis, and hypodermis.
[Acta Biomaterialia]
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Protective Effects of Cannabidiol on the Membrane Proteins of Skin Keratinocytes Exposed to Hydrogen Peroxide via Participation in the Proteostasis Network

The authors evaluated the effects of cannabidiol, a phytocannabinoid known for its antioxidant and anti-inflammatory properties, on the proteome of keratinocyte membranes exposed to hydrogen peroxide.
[Redox Biology]
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Effect of 3D-Fibroblast Dermis Constructed by Layer-by-Layer Cell Coating Technique on Tight Junction Formation and Function in Full-Thickness Skin Equivalent

Researchers investigated the effect of the 3D-fibroblast dermis on the expression of tight junction (TJ)-related proteins and TJ function in layer-by-layer-3D Skin.
[ACS Biomaterials Science & Engineering]
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High-Throughput Compound Screening Identifies Navitoclax Combined with Irradiation as a Candidate Therapy for HPV-Negative Head and Neck Squamous Cell Carcinoma

Scientists ran an assay using five human papillomavirus (HPV)-negative head and neck squamous cell carcinoma cell lines cultured on the human tumor-derived matrix Myogel.
[Scientific Reports]
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Antigen Processing, Presentation, and Tolerance: Role in Autoimmune Skin Diseases

Increased autoantigen presentation by HLA molecules, cross-activation of pathogen-induced T cells against autologous structures, altered metabolism of self-proteins, and excessive production of proinflammatory signals may all contribute to the breakdown of immune tolerance and the development of autoimmune skin diseases.
[Journal of Investigative Dermatology]
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