Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

Nutrient-Delivery and Metabolism Reactivation Therapy for Melanoma

[Nature Nanotechnology] Investigators reported a nutrient-based metabolic reactivation strategy for effective melanoma treatment. L-Tyrosine–oleylamine nanomicelles were constructed for targeted supplementation of tyrosine to reactivate melanogenesis in melanoma cells.

Enspectra Health Receives FDA Breakthrough Device Designation for AI-Powered Imaging Platform Targeting Skin Cancer

[Enspectra Health, Inc. (BioSpace)] Enspectra Health announced that the US FDA has granted Breakthrough Device Designation for its next generation AI-powered VIO Skin Platform for the evaluation of lesions suspicious of basal cell carcinoma and squamous cell carcinoma in select high risk populations.

Replimune Announces Positive Topline Primary Analysis Data by Independent Central Review from IGNYTE Clinical Trial of RP1 plus Nivolumab in Anti-PD1 Failed Melanoma

[Replimune Group, Inc.] Replimune Group, Inc. announced the topline results from the primary analysis of the IGNYTE clinical trial of RP1 plus nivolumab in anti-PD1 failed melanoma. The results by independent central review show one-third of patients receiving RP1 plus nivolumab responded to treatment, with all responses lasting greater than 6 months from baseline.

Valine Aminoacyl-tRNA Synthetase Promotes Therapy Resistance in Melanoma

[Nature Cell Biology] Investigators reported that valine aminoacyl-tRNA synthetase was a key player in the codon-biased translation reprogramming induced by resistance to targeted therapy in melanoma.

How the Combination of Alginate and Chitosan Can Fabricate a Hydrogel with Favorable Properties for Wound Healing.

[Heliyon] The authors discuss the desirable characteristics of an effective wound dressing, explore the alginate/chitosan-based hydrogels developed by different researchers, and analyze their effects on wound healing through in vitro and in vivo assessments.

FBP1 Orchestrates Keratinocyte Proliferation/Differentiation and Suppresses Psoriasis through Metabolic Control of Histone Acetylation

[Cell Death & Disease] Scientists reported that loss of the gluconeogenic enzyme fructose-1,6-bisphosphatase 1 (FBP1) promoted proliferation and inhibited differentiation of keratinocytes in vitro.

Stem Cell-Derived Nanovesicles Embedded in Dual-Layered Hydrogel for Programmed ROS Regulation and Comprehensive Tissue Regeneration in Burn Wound Healing

[Advanced Materials] Investigators designed a dual-layered hydrogel tailored to the process of burn wound repair by programmatically regulating reactive oxygen species and facilitating comprehensive wound tissue repair.

Pulsed Electric Field Induces Exocytosis and Overexpression of MAGE Antigens in Melanoma

[Scientific Reports] Scientists assessed the effects of nanosecond pulsed electric field on melanoma-specific melanoma antigen gene protein family (MAGE) expression and described the consequences of this electric field on melanoma cells' invasion and proliferation potential.

3D-Bioprinted GelMA/Gelatin/Amniotic Membrane Extract (AME) Scaffold Loaded with Keratinocytes, Fibroblasts, and Endothelial Cells for Skin Tissue Engineering

[Scientific Reports] Researchers fabricated and characterized a bi-layered GelMA-gelatin scaffold using 3D bioprinting. The upper section of the scaffold was encompassed with keratinocytes to simulate the epidermis, while the lower section included fibroblasts and HUVEC cells to mimic the dermis.

A Three-Dimensionally Architected Electronic Skin Mimicking Human Mechanosensation

[Science] Investigators reported a 3D architected electronic skin with force and strain sensing components arranged in a 3D layout that mimicked that of Merkel cells and Ruffini endings in human skin.

PRSS3/Mesotrypsin as a Putative Regulator of the Biophysical Characteristics of Epidermal Keratinocytes in Superficial Layers

[Scientific Reports] HaCaT keratinocytes, characterized by minimal endogenous mesotrypsin expression and sustained proliferation in differentiated states, were utilized to further scrutinize the function of mesotrypsin.

MGMT Inhibition Regulates Radioresponse in GBM, GSC, and Melanoma

[Scientific Reports] Investigators evaluated whether O6-methylguanine-DNA methyltransferase (MGMT) expression affected the radioresponse of human glioblastoma (GBM), GBM stem-like cells, and melanoma. They reported a correlation between MGMT promoter methylation status and MGMT expression.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.