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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
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PROTAC-Mediated Degradation of Bcl-Xl Potentiates Target Therapy in Preclinical Melanoma Models
[Journal of Experimental & Clinical Cancer Research] To investigate the effect of the combination treatment in vivo, A375luc melanoma cells were inoculated in xenograft mice, then treated with Dabrafenib/Trametinib or DT2216, alone or in combination, for three weeks.
A Multiaxial Bioreactor Integrated with an Environmental Monitoring System for Tissue-Engineered Skin Grafts
[Advanced Healthcare Materials] Researchers introduced a novel multiaxial bioreactor system that provided uniform stretching of skin grafts with continuous environmental monitoring capabilities.
Topical Carrier-Free Delivery of Finasteride and Peptides for Enhanced Hair Growth
[Biomacromolecules] Scientists developed a peptide-based, carrier-free topical delivery system that enhances hair growth while minimizing systemic exposure to finasteride.
Frontiers in the Physiology of Male Pattern Androgenetic Alopecia: Beyond the Androgen Horizon
[Physiological Reviews] The authors discuss potential targets for future therapeutic intervention beyond androgens and highlight selected dysregulated signaling pathways in male pattern androgenetic alopecia.
α-Terpineol Induces Apoptosis in Melanoma Cells and Its Underlying Mechanism
[Scientific Reports] In vitro studies demonstrated that α-terpineol inhibits melanoma cell proliferation, migration, and invasion by triggering apoptosis.
Chimeric Antigen Receptor Dendritic Cells Suppress Melanoma Growth in Preclinical Cancer Models
[Journal for Immunotherapy of Cancer] Investigators tested whether dendritic cells armed with an anti-HER2 chimeric antigen receptor would suppress the growth of melanoma tumors in a preclinical mouse model.
5-HT Reuptake Blockade Induces Pyroptosis in BRAFV600E-Mutated Melanomas via Remodeling Histone Serotonylation
[Cell Reports Medicine] Scientists identified paroxetine hydrochloride, an FDA-approved antidepressant, as an alternative therapeutic for BRAFV600E-mutated melanoma, including BRAFi/MEKi-resistant cases.
Phytochemical Profiling of Rosmarinus officinalisAerial Parts and Exploring Its In Vitro Wound Healing Activity and Network Pharmacology
[Scientific Reports] Scientists assessed the wound healing efficacy of fractions derived from Rosmarinus officinalis through phytochemical profiling, antioxidant assays, and in vitro scratch wound models, along with network pharmacology to identify target genes.
The AKT-P21 Phosphorylation Signaling Axis Confers Poor Prognosis and Dacarbazine Resistance in Melanoma
[Scientific Reports] Researchers revealed that increased gene and protein expression of p21 is a strong predictor of poor prognosis in human melanoma, while reducing p21 makes these cells more responsive to chemotherapy.
A Smart Self-Oxygenating System for Localized and Sustained Oxygen Delivery in Bioengineered Tissue Constructs
[Communications Materials] Diabetic wound healing studies using mouse models showed that an smart self-oxygenating tissue patch accelerated wound closure in chronic and non-chronic wounds.
PolarityBio Announces AMA Publication of New Category III CPT Codes for SkinTE® Procedures
[ PolarityBio©] PolarityBio© announced that the American Medical Association has published new Category III CPT® codes for its flagship autologous heterogeneous skin construct product, SkinTE®, which provides standardized procedural definitions for both full-thickness skin harvest and SkinTE graft application.
High-Salt Diet Induces Immune-Independent Re-Differentiation, Metabolic Shut Down, and Cell Cycle Arrest of Melanoma
[Cell Death & Disease] Investigators showed that a high salt diet inhibits melanoma growth independent of sodium accumulation and immune cells in skin and lung.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
