Evelo Biosciences Completes Enrollment to Interim Target in Phase II Trial Evaluating EDP1815 for the Treatment of Psoriasis

Evelo Biosciences, Inc. announced that it is recruiting ahead of schedule and has completed enrollment of the patients necessary for the interim data readout in the Phase II clinical trial evaluating EDP1815 for the treatment of mild to moderate psoriasis. The interim data readout includes initial safety and efficacy data for the first 113 patients enrolled in the trial.
[Evelo Biosciences, Inc. (Globe Newswire, Inc)]
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PolarityTE Receives Allowance for First US Patent

PolarityTE, Inc. report that the US. Patent and Trademark Office has issued a Notice of Allowance for U.S. Application No. 14/954,335. This was the company’s first patent allowance in the United States. This patent application covers methods of making compositions for regenerating functional skin tissue using the company’s minimally polarized functional unit technology.
[PolarityTE, Inc.]
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The Melanoma Brain Metastatic Microenvironment: Aldolase C Partakes in Shaping the Malignant Phenotype of Melanoma Cells – A Case of Inter-Tumor Heterogeneity

Researchers used brain metastasizing variants from three human melanomas to explore the functional role of Aldolase C in the formation and maintenance of melanoma brain metastasis.
[Molecular Oncology]
Izraely, S., Ben‐Menachem, S., Sagi‐Assif, O., Meshel, T., Malka, S., Telerman, A., Bustos, M. A., Ramos, I. R., Pasmanik‐Chor, M., Hoon, D. S. B., & Witz, I. P. (n.d.). The melanoma brain metastatic microenvironment: Aldolase C partakes in shaping the malignant phenotype of melanoma cells - A case of inter-tumor heterogeneity. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12872 Cite
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High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions

The authors summarize the newly identified changes in the metabolism, composition, and function of HDL in allergies and skin diseases. They also highlight the possible pathophysiological consequences with a focus on HDL-mediated immunomodulatory activities.
[Biomedicines]
Trakaki, A., & Marsche, G. (2020). High-Density Lipoprotein (HDL) in Allergy and Skin Diseases: Focus on Immunomodulating Functions. Biomedicines, 8(12), 558. https://doi.org/10.3390/biomedicines8120558 Cite
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CERKL is Upregulated in Cutaneous Squamous Cell Carcinoma and Maintains Cellular Sphingolipids and Resistance to Oxidative Stress

Ceramide Kinase‐Like Protein (CERKL) expression was determined by RNA‐Seq, qPCR and immunohistochemistry. CERKL was knocked down in cutaneous squamous cell carcinoma cells using siRNA.
[British Journal of Dermatology]
Meyer, J. M., Lee, E., Celli, A., Park, K., Cho, R., Lambert, W., Pitchford, M., Gordon, M., Tsai, K., Cleaver, J., Arron, S. T., & Mauro, T. M. (n.d.). CERKL is Upregulated in Cutaneous Squamous Cell Carcinoma and Maintains Cellular Sphingolipids and Resistance to Oxidative Stress. British Journal of Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjd.19707 Cite
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Changes in the Physicochemical Properties of Blood and Skin Cell Membranes as a Result of Psoriasis Vulgaris and Psoriatic Arthritis Development

Scientists investigated the effect of development of psoriasis vulgaris and psoriatic arthritis on the composition and physicochemical properties of skin cell membranes and blood cells.
[International Journal of Molecular Sciences]
Meyer, J. M., Lee, E., Celli, A., Park, K., Cho, R., Lambert, W., Pitchford, M., Gordon, M., Tsai, K., Cleaver, J., Arron, S. T., & Mauro, T. M. (n.d.). CERKL is Upregulated in Cutaneous Squamous Cell Carcinoma and Maintains Cellular Sphingolipids and Resistance to Oxidative Stress. British Journal of Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjd.19707 Cite
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Adipokines in the Skin and in Dermatological Diseases

Investigators provide an overview on how adipokines may integrate into the physiological conditions of the skin by introducing the cell types which are known to produce adipokines as well as the signals that target them. They also discuss data from in vivo and in vitro murine and human studies as well as genetic data on how adipokines may contribute to various aspects of the homeostasis of the skin just as to the pathogenesis of dermatological diseases.
[International Journal of Molecular Sciences]
Kovács, D., Fazekas, F., Oláh, A., & Törőcsik, D. (2020). Adipokines in the Skin and in Dermatological Diseases. International Journal of Molecular Sciences, 21(23), 9048. https://doi.org/10.3390/ijms21239048 Cite
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The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway

The anti-cancer mechanism of Isoquercitrin (IQ) against human melanoma, particularly its effect on the mitochondria-mediated apoptosis, was investigated. Treatment with IQ at 25 μM concentration effectively inhibited the proliferation of SK-MEL-2 skin cancer cells while the same concentration did not exhibit cytotoxicity against human keratinocytes HaCaT.
[Nutrients]
Won, Y.-S., Kim, J.-H., Lizardo, R. C. M., Min, H.-J., Cho, H.-D., Hong, S.-M., & Seo, K.-I. (2020). The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway. Nutrients, 12(12), 3683. https://doi.org/10.3390/nu12123683 Cite
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BH3 Mimetics Potentiate Pro-Apoptotic Activity of Encorafenib in BRAFV600E Melanoma Cells

Researchers investigated five BRAFV600E melanoma cell lines derived from drug-naïve tumor specimens to assess cell death response to encorafenib, a recently FDA-approved BRAFV600E inhibitor.
[Cancer Letters]
Hartman, M. L., Gajos-Michniewicz, A., Talaj, J. A., Mielczarek-Lewandowska, A., & Czyz, M. (2020). BH3 mimetics potentiate pro-apoptotic activity of encorafenib in BRAFV600E melanoma cells. Cancer Letters. https://doi.org/10.1016/j.canlet.2020.11.036 Cite
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Tailoring of Silica-Based Nanoporous Pod by Spermidine Multi-Activity

Spermidine bioactivity was employed for targeting tumor cell over-expressed polyamine transport system and for effective delivery of functional miRNA into melanoma cells.
[Scientific Reports]
Della Rosa, G., Di Corato, R., Carpi, S., Polini, B., Taurino, A., Tedeschi, L., Nieri, P., Rinaldi, R., & Aloisi, A. (2020). Tailoring of silica-based nanoporous pod by spermidine multi-activity. Scientific Reports, 10(1), 21142. https://doi.org/10.1038/s41598-020-77957-4 Cite
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The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform that Aging Slowly Alters

Scientists combine recent and older data on organization of the dermal-epidermal junction, its mechanical properties and role in mechanotransduction, its involvement in regeneration, and its fate during the aging process.
[Biomolecules]
Roig-Rosello, E., & Rousselle, P. (2020). The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters. Biomolecules, 10(12), 1607. https://doi.org/10.3390/biom10121607 Cite
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