Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

LPS-Pretreatment Adipose-Derived Mesenchymal Stromal Cells Promote Wound Healing in Diabetic Rats by Improving Angiogenesis

[injury-International Journal of the Care of the injured] Researchers investigated the impact of LPS pretreated human adipose-derived MSCs on skin wound healing in diabetic rats.

Snail Maintains the Stem/Progenitor State of Skin Epithelial Cells and Carcinomas through the Autocrine Effect of Matricellular Protein Mindin

[Cell Reports] In models of cutaneous squamous cell carcinoma, investigators discovered a non-epithelial-mesenchymal transition function for the transcription factor Snail in maintaining the stemness of epidermal keratinocytes.

Topical Application of an Irreversible Small Molecule Inhibitor of Lysyl Oxidases Ameliorates Skin Scarring and Fibrosis

[Nature Communications] Researchers described the development and characterisation of an irreversible lysyl oxidase inhibitor, PXS-6302.

Melanoma Stimulates the Proteolytic Activity of HaCaT Keratinocytes

[Cell Communication and Signaling] Scientists used two in vitro models, melanoma-conditioned media and indirect co-culture of keratinocytes with melanoma cells, to activate immortalized keratinocytes towards cancer-associated ones.

Targeting the USP7/RRM2 Axis Drives Senescence and Sensitizes Melanoma Cells to Hdac/LSD1 Inhibitors

[Cell Reports] Researchers show that USP7 downregulation induced cellular senescence, arresting melanoma growth in vivo and proliferation in vitro in BRAF- and NRAS-mutant melanoma.

A Cellular Hierarchy in Melanoma Uncouples Growth and Metastasis

[Nature] By combining mouse genetics, single-cell and spatial transcriptomics, lineage tracing and quantitative modelling, investigators provided evidence of a hierarchical model of tumour growth that mirrored the cellular and molecular logic underlying the cell-fate specification and differentiation of the embryonic neural crest.

Actin Cable Formation and Epidermis–Dermis Positional Relationship during Complete Skin Regeneration

[Scientific Reports] Scientists found that the three-dimensional structure of the skin was completely regenerated in full-thickness skin incisions made before embryonic day 13.

Ionic Complexation Improves Wound Healing in Deep Second-Degree Burns and Reduces In-Vitro Ciprofloxacin Cytotoxicity in Fibroblasts

[Scientific Reports] Antibiotic-anesthetic smart systems obtained by ionic complexation of polyelectrolytes with ciprofloxacin and lidocaine were obtained as films and hydrogels.

Hair Follicle Melanocytes Initiate Autoimmunity in Alopecia Areata: a Trigger Point

[Clinical Reviews in Allergy & Immunology] Scientists present a narrative review on the roles of melanocytes in alopecia areata pathogenesis, aiming to provide a better understanding of this disease from the melanocyte’s perspective.

The Role of Myofibroblasts in Physiological and Pathological Tissue Repair

[Cold Spring Harbor Perspectives in Biology] The authors focus on the central role of the cell, extracellular matrix, and tissue mechanics in regulating tissue repair by controlling myofibroblast action, and also discuss how therapies based on mechanical intervention potentially ameliorate wound healing outcomes.

AlphaFold Developers Win US$3-Million Breakthrough Prize

[Nature News] Demis Hassabis and John Jumper, both at DeepMind in London, were recognized for creating the tool that has predicted the 3D structures of almost every known protein on the planet.

Protective Effect of Human Amniotic Membrane Extract against Hydrogen Peroxide-Induced Oxidative Damage in Human Dermal Fibroblasts

[International Journal of Cosmetic Science] This experimental study aimed to investigate the antioxidant activity of human amniotic membrane extract against hydrogen peroxide-induced dermal fibroblast damage.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.