Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

The Mechano-Chemical Circuit in Fibroblasts and Dendritic Cells Drives Basal Cell Proliferation in Psoriasis

[Cell Reports] By employing mouse psoriasis and skin organoid models, investigators discovered a mechano-chemical signaling pathway that originated from dendritic cells, extended to dermal fibroblasts, and ultimately enhanced basal cell proliferation in psoriatic skin.

Shifts in Keratin Isoform Expression Activate Motility Signals during Wound Healing

[Developmental Cell] Investigators reported an unexpected effect of keratin isoform variation on kinase signal transduction. Increased expression of wound-associated keratin 6A, but not of steady-state keratin 5, potentiated keratinocyte migration and wound closure without compromising mechanical stability by activating myosin motors to increase contractile force generation.

Biogenesis of Specialized Lysosomes in Differentiated Keratinocytes Relies on Close Apposition with the Golgi Apparatus

[Cell Death & Disease] Researchers uncovered a novel form of Golgi-lysosome cross-talk and its role in maintaining specialized secretory lysosomes in differentiated keratinocytes.

Feedforward Cysteine Regulation Maintains Melanoma Differentiation State and Limits Metastatic Spread

[Cell Reports] Researchers demonstrated that cysteine availability, whether from lysosomes or exogenously derived, controlled melanoma differentiation-associated pathways by acting on the melanocyte master regulator microphthalmia-associated transcription factor.

A Scalable and cGMP-Compatible Autologous Organotypic Cell Therapy for Dystrophic Epidermolysis Bullosa

[Nature Communications] The authors refined a practical and simplified current Good Manufacturing Practice (cGMP)-compatible protocol for the generation of genetically corrected autologous organotypic skin grafts that included keratinocytes, dermal fibroblasts, and melanocytes for the long-term healing of Dystrophic Epidermolysis Bullosa patient wounds.

Obsidian Therapeutics Announces FDA Fast Track Designation for OBX-115 for the Treatment of Advanced Melanoma

[Obsidian Therapeutics, Inc.] Obsidian Therapeutics, Inc. announced that the US FDA has granted Fast Track Designation to OBX-115, a novel engineered tumor-derived autologous T cell immunotherapy armored with pharmacologically regulatable membrane-bound IL15, for the treatment metastatic or locally advanced melanoma that is refractory to or has relapsed after PD-1/PD-L1–based immune checkpoint inhibitors.

Defence Receives No Objection Letter from Health Canada for Phase I Trial of Its Accum-002 (Accutox) as an Anti-cancer Molecule in Patients with Melanoma

[Defence Therapeutics, Inc.] Defence Therapeutics, Inc. announced that it received a No Objection Letter from Health Canada for its Clinical Trial Study number ACCUM-002-01 entitled “A Phase I trial of Intratumoral Administration of ACCUM-002TM as a Monotherapy and in Combination with Opdualag in Patients with Unresectables, Stage IIIB and IV, Melanoma".

Variations in Fluid Chemical Potential Induce Fibroblast Mechano-Response in 3D Hydrogels

[Biomaterials Advances] Researchers investigated the specific influences of hydrostatic and osmotic pressure on primary human dermal fibroblasts in three-dimensional hydrogel culture models.

Epithelial-Mesenchymal Plasticity (EMP) in Wound Healing: Exploring EMT Mechanisms, Regulatory Network, and Therapeutic Opportunities

[Heliyon] The authors review the regulatory roles of key signaling pathways and core transcription factors in epithelial-to-mesenchymal transition (EMT), explore the parallels between re-epithelialization and EMT, and outline recent therapeutic advances and future developments targeting EMT in wound healing.

Involvement of Kindlin-1 in Cutaneous Squamous Cell Carcinoma

[Oncogenesis] Investigators reported that loss of Kindlin-1 led to increased cutaneous squamous cell carcinoma tumor growth in vivo and in 3D spheroids, which was associated with the development of a hypoxic tumor environment and increased glycolysis.

Leo Foundation Awards Grant to Buganim’s Lab to Research Fibroblast Dysfunction and Skin Rejuvenation

[The Hebrew University of Jerusalem] The Leo Foundation has awarded a $600,000 grant to Dr. Yossi Buganim’s lab at The Hebrew University of Jerusalem to support groundbreaking research on fibroblast dysfunction in aging skin. This project aims to develop innovative technology for rejuvenating aged fibroblasts to improve wound healing.

Eirion Therapeutics Announces Initiation of First-in-Human Clinical Trial Evaluating Topical ET-02 for the Treatment of Androgenic Alopecia

[Eirion Therapeutics Inc.] Eirion Therapeutics, Inc. announced that the first participant has been enrolled in a Phase I clinical trial to evaluate the safety of the patented topical pharmaceutical ET-02 for the treatment of androgenic alopecia. This double-blind, placebo-controlled study is designed to determine the safety of ET-02 for once daily treatment over 28 days.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.