Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

PIKFYVE Inhibitors Trigger Interleukin-24-Dependent Cell Death of Autophagy-Dependent Melanoma

[Molecular Oncology] Autophagy-dependent melanoma cells were compared with normal foreskin fibroblasts to elucidate the mechanism by which 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) inhibition induces cell death.

Cinnamic Acid Promotes Elongation of Hair Peg-Like Sprouting in Hair Follicle Organoids via Oxytocin Receptor Activation

[Scientific Reports] Treatment with cinnamic acid led to upregulation of oxytocin receptor and trichogenic gene expression in human dermal papilla cells.

Gasdermin E Promotes Translocation of p65 and C-jun into Nucleus in Keratinocytes for Progression of Psoriatic Skin Inflammation

[Cell Death & Disease] Through analysis of GEO datasets, we found elevated Gasdermin E (GSDME) levels in psoriatic lesional skin. Additionally, GSDME levels correlated with both psoriasis severity and response to biologics treatments.

Oct4 Is a Gatekeeper of Epithelial Identity by Regulating Cytoskeletal Organization in Skin Keratinocytes

[Cell Reports] Investigators generated OCT4 knockout clonal cell lines using immortalized human skin keratinocytes to identify a functional role for the protein.

3D Modeling of Normal Skin and Cutaneous Squamous Cell Carcinoma. A Comparative Study in 2D Cultures, Spheroids, and 3D Bioprinted Systems

[Biofabrication] Scientists developed an innovative in vitro human three-dimensional (3D) normal skin model and a multicellular model of human cutaneous squamous cell carcinoma using 3D bioprinting technology.

Daturataturin a Ameliorates Psoriasis by Regulating PPAR Pathway

[Biochemical Genetics] Researchers elucidated the effect of daturataturin A on psoriasis and its potential mechanism. They established a daturataturin A psoriasis-like keratinocytes model by stimulating HaCaT cells with M5 cocktail cytokines including Interleukin (IL)-17A, IL-22, oncostatin M, IL-1α, and tumor necrosis factor-α (TNF-α), followed by intervention with DTA.

Dormancy of Cutaneous Melanoma

[Cancer Cell International] The authors focus on the mechanisms regulating the initiation of cutaneous melanoma dormancy as well as those that are involved in the reawakening of dormant cutaneous melanoma cells.

SOCS5-RBMX Stimulates SREBP1-Mediated Lipogenesis to Promote Metastasis in Steatotic HCC ith HBV-Related Cirrhosis

[NPJ Precision Oncology] Hematoxylin-eosin staining of 245 HCC samples revealed a special HCC subtype characterized by HBV-related cirrhosis and intratumoral steatosis without fatty liver background, defined as steatotic HCC with HBV-related cirrhosis.

New Breakthrough Therapy for Metastatic Melanoma Receives FDA Approval

[Moffitt Cancer Center] A first-of-its-kind cellular immunotherapy pioneered at Moffitt Cancer Center is now available for patients with advanced melanoma. It’s called TIL, short for tumor-infiltrating lymphocyte therapy. The one-time T-cell therapy infusion uses a patient’s own immune cells to fight their cancer.

A Neuroligin-2-YAP Axis Regulates Progression of Pancreatic Intraepithelial Neoplasia

[Advanced Materials] Researchers successfully engineered an adenosine 5′-triphosphate-responsive manganese-based bacterial material that exhibitd an exceptional ability to synergistically activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING pathway.

Generation of Induced Pluripotent Stem Cell Line NIMHi010-A from Dermal Fibroblast Cells of a Healthy Individual

[Stem Cell Research] Scientists established hiPSC line, NIMHi010-A of a 42-year-old healthy donor. The iPSC line was generated from human dermal fibroblasts using Sendai viruses carrying reprogramming factors c-MYC, SOX2, KLF4, and OCT4 under a feeder-free culture system.

LIGHT Signaling through LTβR and HVEM in Keratinocytes Promotes Psoriasis and Atopic Dermatitis-Like Skin Inflammation

[Journal Of Autoimmunity] Scientists showed that tumor necrosis factor superfamily member 14 (TNFSF14), known as LIGHT, is required for experimental psoriasis, similar to its requirement in experimental atopic dermatitis.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.