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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Oxyresveratrol Enhances Hair Regeneration in Human Dermal Papilla Cell and Androgenetic Alopecia Mouse Model
[Scientific Reports] Researchers evaluated the effects of oxyresveratrol on human follicle dermal papilla cells and an androgenetic alopecia mouse model.
Hydrodynamically Generated Multilayer Skin Spheroids Enable In Vitro Screening of Biologically Active Ingredients and Toxicity Tests
[Science Advances] Researchers developed a hydrodynamically mediated approach to the generation of large arrays of fibroblast spheroids (a dermal core) that were engulfed with an epidermal layer of keratinocytes.
SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation
[Aging Cell] Scientists identified sequestosome1 (SQSTM1/p62) as a key regulator of senescence, the senescence-associated secretory phenotype, and skin aging.
Targeting the MAPK Pathway for NRAS Mutant Melanoma: From Mechanism to Clinic
[British Journal of Dermatology] The authors summarize advances in the direct targeting of mutant NRAS proteins and their downstream RAF and MEK proteins, as well as targeting the MAPK pathway in combination with other therapeutic targets to treat NRAS mutant melanoma.
Effective TIL Therapy for Patients with Checkpoint-Resistant Melanoma without Lymphodepleting Regimens Requires Interferon-Alpha.
[Clinical Cancer Research] Scientists investigated the impact of a pegylated interferon-alpha conditioning and support regimen on the safety and efficacy of tumor infiltrating lymphocytes plus Nivolumab.
Hedgehog Signaling Pathway Inhibitors in the Treatment of Basal Cell Carcinoma: An Updated Review
[Journal of Drug Targeting] The authors summarize basal cell carcinoma's (BCC's) clinical presentation and histopathology and present knowledge on the most studied Hh signaling inhibitors, vismodegib and sonidegib, and other inhibitors of this signalling, such as itraconazole, patidegib, taladegib, and arsenic trioxide, in the treatment of BCC.
FOSL1 Promotes Keratinocyte Migration and Wound Repair by Modulating the IL17 Signaling Pathway
[Scientific Reports] Scientists explores the role and regulatory mechanisms of Fos-like antigen-1 (FOSL1) in the wound-healing process.
Reannotation of Cancer Mutations Based on Expressed RNA Transcripts Reveals Functional Non-Coding Mutations in Melanoma
[American Journal of Human Genetics] Investigators developed a method to detect significant clusters of synonymous and missense mutations in public cancer genomics data. They propose a simple automated method to more accurately annotate cancer mutations based on expressed transcripts.
U.S. FDA Approves ZEVASKYNâ„¢ (prademagene zamikeracel), the First and Only Cell-Based Gene Therapy for Patients with Recessive Dystrophic Epidermolysis Bullosa (RDEB)
[Abeona Therapeutics, Inc.] Abeona Therapeutics, Inc. announced the US FDA has approved ZEVASKYNâ„¢ gene-modified cellular sheets, also known as pz-cel, as the first and only autologous cell-based gene therapy for the treatment of wounds in adult and pediatric patients with recessive dystrophic epidermolysis bullosa.
ZNF224 Enhances the Oncogenic Function of P21 via P53 and AKT Pathways in Melanoma
[FEBS Journal] Scientists investigated the molecular mechanisms underlying the oncogenic role of zinc finger protein 224 (ZNF224) in melanoma.
Molecular and Immune Landscape of Melanoma: A Risk Stratification Model for Precision Oncology
[Discover Oncology] Investigators provided a robust immune-related prognostic model for melanoma. They underscored the value of immune gene expression and T cell infiltration, particularly CD8+ T cells, in predicting patient outcomes.
Investigating the Properties of Truncal Acne: A Common but Often Overlooked Entity
[Journal of Cutaneous Medicine and Surgery] Researchers investigated the prevalence of truncal acne in patients with mild, moderate, and severe acne and evaluated the characteristics of truncal acne.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
