Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

Delayed Collagen Production Without Myofibroblast Formation Contributes to Reduced Scarring in Adult Skin Micro-Wounds

[Journal Of Investigative Dermatology] The study delineated the cellular attributes of microthermal zones, underscoring a temporally limited, subclinical inflammatory milieu concomitant with rapid re-epithelialization within 24 hours.

Involvement of DKK1 Secreted from Adipose-Derived Stem Cells in Alopecia Areata

[Cell Proliferation] Treatment with recombinant DKK1 resulted in a decrease of cell growth in outer root sheath cells, whereas the use of a DKK1 neutralising antibody promoted hair growth.

MGRN1 Depletion Promotes Intercellular Adhesion in Melanoma by Upregulation of E-Cadherin and Inhibition of CDC42

[Cancer Letters] Scientists investigated the role of Mahogunin Ring Finger 1 (MGRN1) on human melanoma cell morphology, adhesion, and expression of genes/proteins involved in an EMT-like transition.

Epigenetic Switch Reshapes Epithelial Progenitor Cell Signatures and Drives Inflammatory Pathogenesis in Hidradenitis Suppurativa

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers investigated hidradenitis suppurativa epithelial cells and demonstrated that hidradenitis suppurativa basal progenitors modulated their lineage restriction and gave rise to pathogenic keratinocyte clones, resulting in epidermal hyperproliferation and dysregulated inflammation.

PRMT1 Inhibition Activates the Interferon Pathway to Potentiate Antitumor Immunity and Enhance Checkpoint Blockade Efficacy in Melanoma

[Cancer Research] Researchers found that protein arginine methyl transferase 1 (PRMT1) expression was inversely correlated with the number and activity of CD8+ T cells within melanoma specimen.

Sulforaphane Alleviates Psoriasis by Enhancing Antioxidant Defense through KEAP1-NRF2 Pathway Activation and Attenuating Inflammatory Signaling

[Cell Death & Disease] In vitro experiments using HaCaT cells demonstrated that sulforaphane inhibited IL-22 and TNF-α-induced activation of inflammatory pathways and keratinocyte proliferation.

Epidermal or Dermal Collagen VII Is Sufficient for Skin Integrity – Insights to Anchoring Fibril Homeostasis

[Journal Of Investigative Dermatology] Scientists engineered mice that kept physiological expression of collagen VII only in epithelial cells or in fibroblasts, revealing that production of collagen VII either by keratinocytes or fibroblasts alone was sufficient for creation of mechanically robust skin.

Upregulated Expression of miR-4443 and miR-4488 in Drug Resistant Melanomas Promotes Migratory and Invasive Phenotypes Through Downregulation of Intermediate Filament Nestin

[Journal Of Experimental & Clinical Cancer Research] miR-4488 and miR-4443 were measured by qRT-PCR. Nestin levels were tested by western blot, confocal immunofluorescence, immunohistochemical and flow cytometry analyses.

Epidermal–Dermal Coupled Spheroids Are Important for Tissue Pattern Regeneration in Reconstituted Skin Explant Cultures

[NPJ Regenerative Medicine] To advance the use of engineered reconstituted skin organs, researchers studied cardinal features important for tissue patterning and hair regeneration, finding that they spontaneously formed spheroid configurations, with polarized epidermal cells coupled with dermal cells through a newly formed basement membrane.

Vector-Borne Trypanosoma brucei Parasites Develop in Artificial Human Skin and Persist As Skin Tissue Forms

[Nature Communications] The authors introduced an advanced human skin equivalent and used tsetse flies to naturally infect the skin with trypanosomes.

Navigating the Landscape of Psoriasis Therapy: Novel Targeted Pathways and Emerging Trends

[Expert Opinion On Therapeutic Targets] The authors focus on intracellular and molecular mechanisms such as AhR, A3AR, RIP1, CGRP, and S1P that serve as novel pharmacological targets for psoriasis, and on new molecules now approved or under clinical investigation to interfere with these target mechanisms.

MiR126-Targeted-Nanoparticles Combined with PI3K/AKT Inhibitor as a New Strategy to Overcome Melanoma Resistance

[Molecular Therapy] Scientists synthesized chitosan nanoparticles containing a chemically modified miR126 sequence, which were further functionalized with an antibody specific to the chondroitin sulfate proteoglycan 4 melanoma marker.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.