VYNE Therapeutics Announces Phase Ib Data for FMX114 from Phase Ib/IIa Trial for the Treatment of Mild-to-Moderate Atopic Dermatitis

VYNE Therapeutics, Inc. announced that it has completed the Phase Ib portion of a Phase Ib/IIa clinical trial evaluating FMX114 for the treatment of mild-to-moderate atopic dermatitis
[VYNE Therapeutics, Inc.]
[zotpress userid=” items=’nan’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Trehangelins Ameliorate Inflammation-Induced Skin Senescence by Suppressing the Epidermal YAP-CCN1 Axis

Researchers described a possible mechanism involved in skin aging focusing on the effect of Trehangelins on epidermal cellular communication metwork factor 1 (CCN1).
[Scientific Reports]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Discrimination of Hand-Foot Skin Reaction Caused by Tyrosine Kinase Inhibitors Based on Direct Keratinocyte Toxicity and Vascular Endothelial Growth Factor Receptor-2 Inhibition

The authors explained the incidence of hand-foot skin reaction in patients treated with tyrosine kinase inhibitors by focusing on keratinocyte toxicity and inhibition of vascular endothelial growth factor receptor, which played an essential role in angiogenesis.
[Biochemical Pharmacology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Therapeutic Downregulation of Neuronal PAS Domain 2 (Npas2) Promotes Surgical Skin Wound Healing

The hit compound (Dwn1) suppressed circadian Npas2 expression, increased murine dermal fibroblast cell migration, and decreased collagen synthesis in vitro.
[eLife]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

The Effect of a Static Magnetic Field and Baicalin or Baicalein Interactions on Amelanotic Melanoma Cell Cultures (C32)

The authors evaluated the simultaneous exposure of melanoma cells to flavones and the static magnetic fields that were generated by permanent magnets on the gene expression and the activity of the antioxidant enzymes that were associated with the antioxidant defense system.
[Molecular Biology Reports]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Reduced Expression of Collagen 17A1 in Naturally Aged, Photoaged, and UV-Irradiated Human Skin In Vivo: Potential Links to Epidermal Aging

Researchers found that matrix metalloproteinases were responsible for ultraviolet (UV)-mediated Collagen 17A degradation in both in vitro keratinocytes and in vivo mouse skin.
[Journal of Cell Communication and Signaling]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

BRAF Inhibitors Reprogram Cancer-Associated Fibroblasts to Drive Matrix Remodeling and Therapeutic Escape in Melanoma

BRAF inhibitor induced BRAF-CRAF heterodimerization and subsequent activation of ERK signaling in cancer-associated fibroblasts, leading to inactivation of the β-catenin destruction complex.
[Cancer Research]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Decursin Prevents Melanogenesis by Suppressing MITF Expression through the Regulation of PKA/CREB, MAPKs, and PI3K/Akt/GSK-3β Cascades

Decursin exhibited no cytotoxicity and significantly reduced intracellular tyrosinase activity and melanin content in B16F10 melanoma cells.
[Biomedicine & Pharmacotherapy]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia

Investigators demonstrated that Kelch-like protein 24 (KLHL24) played a role in hair maintenance by regulating the cytoskeleton structure of hair follicle stem cells (HFSCs) and highlighted the importance of the ubiquitin-proteasome system in the stability of HFSCs.
[Journal of Investigative Dermatology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

TSLP Impairs Epidermal Barrier Integrity by Stimulating the Formation of Nuclear IL-33/Phosphorylated STAT3 Complex in Human Keratinocytes

Researchers stimulated post-confluent human keratinocytes and living skin equivalent with TSLP to investigate the role of nuclear IL-33 in TSLP-induced epidermal barrier defects.
[Journal of Investigative Dermatology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Advances in the Pathogenesis of Psoriasis: From Keratinocyte Perspective

The authors review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions.
[Cell Death & Disease]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share