Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

Exosomal miR-211-5p Regulates Glucose Metabolism, Pyroptosis, and Immune Microenvironment of Melanoma through GNA15

[Pharmacological Research] Researchers showed that the highly metastatic melanoma tumor cells could transfer their metastatic competency to the low-metastatic melanoma tumor cells by exosomal miR-211-5p.

Fucosylation of HLA-DRB1 Regulates CD4+ T Cell-mediated Anti-Melanoma Immunity and Enhances Immunotherapy Efficacy

[Nature Cancer] The authors reported that dietary administration of L-fucose induced fucosylation and cell surface enrichment of the major histocompatibility complex-II protein HLA-DRB1 in melanoma cells, triggering CD4+ T cell-mediated increases inintratumoral immune cells and anti-tumor immunity.

TRPV3-ANO1 Interaction Positively Regulates Wound Healing in Keratinocytes

[Communications Biology] Using an in vitro wound-healing assay, scientists observed that either a transient receptor potential vanilloid 3 (TRPV3) blocker, an anoctamin1 (ANO1) blocker, or low chloride medium inhibited keratinocyte migration and proliferation through p38 phosphorylation.

DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

[Science Advances] Using Keratin 14–Cre–driven ablation of Tet genes in skin epithelial cells, investigators demonstrated that ablation of Tet2/Tet3 resulted in marked alterations of hair shape and length followed by hair loss.

Antiangiogenic Activity of the Penicillin Derivative TAP7f in Melanoma

[Journal Of Molecular Medicine] In a gel plug assay TAP7f blocked vascular formation induced by fibroblast growth factor 2. Furthermore, when murine B16-F10 melanoma cells pre-treated with TAP7f were injected intradermally in mice, investigators observed a decrease in the number and thickness of the capillaries surrounding the tumor.

Printable Hyaluronic Acid Hydrogel Functionalized with Yeast-Derived Peptide for Skin Wound Healing

[International Journal Of Biological Macromolecules] Scientists developed printable hyaluronic acid based hydrogel to deliver yeast-derived ACE-inhibitory peptide of VLSTSFPPW to the wound site. Fibroblast cells seeded on the peptide-modified hydrogels exhibited higher viability than the hydrogels without the peptide.

Multiple Predictive Biomarker Testing in Melanoma: Another Challenge for the Optimal Approach on Cytological Samples

[Cytopathology] To examine the utility of fine-needle cytology for PD-L1 assessment, researchers evaluated the cellular adequacy of residual cell block material from metastatic melanomas previously tested for BRAF and NRAS mutations.

Characterization of an Ablative Fractional CO2 Laser-Induced Wound-Healing Model Based on In Vitro 3D Reconstructed Skin

[Journal Of Cosmetic Dermatology] A 3D full-thickness skin model was fabricated and treated with fractional ablativeCO2 laser. Wound-healing process was characterized by HE staining, noninvasive OCT imaging, immunostaining, as well as transepidermal water loss measurement.

Adult Skin Fibroblast State Change in Murine Wound Healing

[Scientific Reports] Investigators analyzed scRNA-seq datasets of normal and wounded skin from mice at day 4 post-wound to investigate fibroblast heterogeneity during the proliferative phase of wound healing.

Epigenetic Regulation of Macrophage Polarization in Wound Healing

[Burns & Trauma] The authors describe the latest knowledge concerning the potential epigenetic mechanisms that precisely regulate the biological function of macrophages and their effects on skin wound healing.

Opportunities and Challenges in the Diagnostic Utility of Dermal Interstitial Fluid

[Nature Biomedical Engineering] Scientists provide an overview of the most meaningful differences in the make-up of interstitial fluid (ISF) and blood, and discuss why ISF cannot be viewed generally as a diagnostically useful proxy for blood.

Evaxion Receives FDA Fast-Track Designation for Personalized Cancer Immunotherapy

[Evaxion Biotech A/S] Evaxion Biotech A/S announced that the FDA has granted fast track designation for their personalized cancer therapy, EVX-01, in combination with KEYTRUDA® for patients with metastatic melanoma.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.