The Anti-Skin Squamous Cell Carcinoma Cell Activity by the SphK1-Targeting microRNA-6784

The authors identified a novel SphK1-targeting microRNA, microRNA-6784 (miR-6784). They showed that miR-6784 was located at the cytoplasm of A431 skin squamous cell carcinoma cells.
[Aging]
Aging | The anti-skin squamous cell carcinoma cell activity by the SphK1-targeting microRNA-6784 - Full Text. (n.d.). Retrieved January 22, 2021, from https://www.aging-us.com/article/202336/text Cite
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Differences of Embedding Adipose-Derived Stromal Cells in Natural and Synthetic Scaffolds for Dermal and Subcutaneous Delivery

Scientists investigate the trends in injectable scaffolds for adipose-derived stromal cell (ASC) delivery in the dermis, and injectable or implantable scaffolds for ASC delivery in the subcutis.
[Stem Cell Research & Therapy]
Differences of embedding adipose-derived stromal cells in natural and synthetic scaffolds for dermal and subcutaneous delivery | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved January 23, 2021, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-02132-5 Cite
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Activation of the Tumor Suppressive Hippo Pathway by Triptonide as a New Strategy to Potently Inhibit Aggressive Melanoma Cell Metastasis

Researchers showed that the small molecule triptonide robustly suppressed melanoma cell tumorigenicity, migration, and invasion.
[Biochemical Pharmacology]
Tan, S., Zhao, Z., Qiao, Y., Zhang, B., Zhang, T., Zhang, M., Qi, J., Wang, X., Meng, M., & Zhou, Q. (2021). Activation of the tumor suppressive Hippo pathway by triptonide as a new strategy to potently inhibit aggressive melanoma cell metastasis. Biochemical Pharmacology, 114423. https://doi.org/10.1016/j.bcp.2021.114423 Cite
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Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase

Human keratinocytes cells were used as an experimental model for studies on the effects of platelet-rich plasma on cell proliferation, migration, collagen biosynthesis, prolidase activity, and its expression and anabolic signaling.
[International Journal of Molecular Sciences]
Misiura, M., Guszczyn, T., Oscilowska, I., Baszanowska, W., Palka, J., & Miltyk, W. (2021). Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase. International Journal of Molecular Sciences, 22(2), 936. https://doi.org/10.3390/ijms22020936 Cite
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NECTIN4: A Novel Therapeutic Target for Melanoma

The authors investigated the role of nectin cell adhesion molecule 4 (NECTIN4) in melanoma and its potency as a therapeutic target using 126 melanoma samples and BRAFi-resistant cells.
[International Journal of Molecular Sciences]
Tanaka, Y., Murata, M., Shen, C.-H., Furue, M., & Ito, T. (2021). NECTIN4: A Novel Therapeutic Target for Melanoma. International Journal of Molecular Sciences, 22(2), 976. https://doi.org/10.3390/ijms22020976 Cite
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CSN6 Promotes Melanoma Proliferation and Metastasis by Controlling the UBR5-Mediated Ubiquitination and Degradation of CDK9

In melanoma cells, constitutive photomorphogenesis 9 signalosome 6 (CSN6) knockdown remarkably inhibited cell proliferation, tumorigenicity, migration, and invasion, whereas CSN6 recovery rescued the proliferative and metastatic abilities.
[Cell Death & Disease]
Zhang, Y., Hou, J., Shi, S., Du, J., Liu, Y., Huang, P., Li, Q., Liu, L., Hu, H., Ji, Y., Guo, L., Shi, Y., Liu, Y., & Cui, H. (2021). CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9. Cell Death & Disease, 12(1), 1–12. https://doi.org/10.1038/s41419-021-03398-0 Cite
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Pannexin 3 Regulates Skin Development via Epiprofin

The authors demonstrated that Pannexin 3 (Panx3) regulated skin development by modulating the transcription factor, Epiprofin (Epfn). In cell culture, Panx3 overexpression promoted HaCaT cell differentiation, cell cycle exit and enhanced Epfn expression.
[Scientific Reports]
Zhang, P., Ishikawa, M., Doyle, A., Nakamura, T., He, B., & Yamada, Y. (2021). Pannexin 3 regulates skin development via Epiprofin. Scientific Reports, 11(1), 1779. https://doi.org/10.1038/s41598-021-81074-1 Cite
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Epidermal Progenitors Suppress GRHL3-Mediated Differentiation through Intronic Polyadenylation Promoted by CPSF-HNRNPA3 Collaboration

Scientists showed that hundreds of intronic polyadenylation sites were differentially used during keratinocyte differentiation, which was accompanied by downregulation of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex.
[Nature Communications]
Chen, X., Lloyd, S. M., Kweon, J., Gamalong, G. M., & Bao, X. (2021). Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration. Nature Communications, 12(1), 448. https://doi.org/10.1038/s41467-020-20674-3 Cite
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Hair Follicle Germs Containing Vascular Endothelial Cells for Hair Regenerative Medicine

Epithelial, dermal papilla, and vascular endothelial cells initially formed a single aggregate, which subsequently became a dumbbell-shaped HFG, wherein the vascular endothelial cells localized in the region of dermal papilla cells.
[Scientific Reports]
Hair follicle germs containing vascular endothelial cells for hair regenerative medicine | Scientific Reports. (n.d.). Retrieved January 18, 2021, from https://www.nature.com/articles/s41598-020-79722-z Cite
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Exosomes from Adipose-Derived Stem Cells and Application to Skin Wound Healing

Scientists describes the mechanisms whereby adipose‐derived stem cells‐exosomes regulate wound healing and their clinical application.
[Cell Proliferation]
An, Y., Lin, S., Tan, X., Zhu, S., Nie, F., Zhen, Y., Gu, L., Zhang, C., Wang, B., Wei, W., Li, D., & Wu, J. (n.d.). Exosomes from adipose-derived stem cells and application to skin wound healing. Cell Proliferation, n/a(n/a), e12993. https://doi.org/https://doi.org/10.1111/cpr.12993 Cite
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Interfollicular Epidermal Stem-Like Cells for the Recreation of the Hair Follicle Epithelial Compartment

Scientists investigated whether human interfollicular epidermal keratinocytes with stem-like features, characterized by a α6bri/CD71dim expression, could replace human hair follicular keratinocytes for the recreation of the hair follicle epithelium and respective epithelial-mesenchymal interactions.
[Stem Cell Research & Therapy]
Abreu, C. M., Pirraco, R. P., Reis, R. L., Cerqueira, M. T., & Marques, A. P. (2021). Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment. Stem Cell Research & Therapy, 12(1), 62. https://doi.org/10.1186/s13287-020-02104-9 Cite
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