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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
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Skin Fibroblast Lineage Tracing Reveals Layer-Specific Cooperation in Wound Repair
[Cell Stem Cell] Scientists employed a dual-recombinase strategy to develop genetic lineage-tracing tools for all five layers of skin fibroblasts and revealed an intricate spatiotemporal pattern of fibroblast contributions across different wound severities.
A Dual-Action Microneedle Patch Inhibiting Keratinocyte Ferroptosis and Scavenging Cell-Free DNA for Psoriasis Treatment
[Advanced Healthcare Materials] Researchers developed a dual-action microneedle system, with needle tips composed of guanidine-functionalized chitosan and deferoxamine (DFO), designed to eliminate pro-inflammatory cell-free DNA while locally releasing DFO for iron chelation.
Dynamic Stratum Corneum Ceramide Alterations Reflect Barrier Dysfunction and Clinical Response to Topical Chlormethine Treatment in Early-Stage Mycosis Fungoides
[International Journal of Pharmaceutics] Investigators characterized barrier function and stratum corneum ceramide profiles in lesional and non-lesional skin of 21 patients with early-stage mycosis fungoides and 10 healthy controls, and assessed how these barrier and ceramide characteristics evolve during chlormethine gel treatment in patients.
GM2A Links Keratinocyte Metabolism to Inflammation in Psoriasis: Integrated Transcriptomic and Functional Analyses
[International Immunopharmacology] Researchers aimed to investigate the molecular mechanisms linking lipid metabolism to psoriasis, integrating transcriptomic datasets and identifying ganglioside GM2 activator (GM2A) as a top lipid metabolism-related hub gene.
Potential Role of Druggable Gene SLC15A2 in Keratinocyte Hyperproliferation in Psoriasis
[Gene] Scientists aimed to identify psoriasis-associated druggable genes using genetic causal inference approaches and to characterize the biological and therapeutic relevance of solute carrier family 15 member 2 (SLC15A2) through multidimensional validation.
Mechanical Stress Induces Nuclear Envelope Rupture in Melanoma Cells to Reorganize Tumor-Stromal Interactions
[Cancer Research] Investigators showed that recurrent macroscopic mechanical stress disrupts nuclear envelope integrity, leading to spatial reorganization and fibroblast subtype changes at the tumor–stromal interface.
Pharmacological Melatonin Induces Mitochondrial Dysfunction and Alters Extracellular Nucleotide Metabolism and CD39/CD73 Expression in Human Melanoma Cells
[Purinergic Signalling] Scientists investigated whether pharmacological melatonin influences metabolic activity, mitochondrial homeostasis, and extracellular nucleotide metabolism in two human melanoma cell lines with distinct molecular profiles.
Acne: Epidemiology, Risk Factors, Pathogenesis, Management, and Cutting-Edge Research
[Signal Transduction and Targeted Therapy] The authors provide a systematic overview of the epidemiology, risk factors, diagnostic classifications, and comorbidities associated with acne, with a particular focus on contemporary insights into its immunopathogenesis, and molecular mechanisms.
Extreme Temperatures and the Epithelial Barrier Theory
[Seminars in Immunopathology] Investigators synthesize mechanistic, environmental, and epidemiological data to highlight extreme temperatures as critical drivers of epithelial barrier dysfunction and global disease burden.
Decoding Cutaneous Injury-Induced Inflammation through Single-Cell RNA Sequencing
[Seminars in Cell & Developmental Biology] Scientists provide a detailed description of validated markers used to identify distinct cellular populations in murine and human skin and discuss how single-cell RNA sequencing has deepened our understanding of mechanisms regulating inflammation during acute wound healing.
Pelage Pharmaceuticals Announces First Patient Dosed in Phase II/III AWAKEN Trial of PP405 for Androgenetic Alopecia, the Most Common Form of Hair Loss
[Pelage Pharmaceuticals] Pelage Pharmaceuticals announced that the first patient has been dosed in the Phase II/III AWAKEN clinical trial evaluating PP405 in adult men with androgenetic alopecia, also known as pattern hair loss.
Paradigm Therapeutics, Inc. Announces First Patient Enrolled in Phase III Trial for SD-101 (ZorblesiaTM) in Epidermolysis Bullosa
[Paradigm Therapeutics, Inc. (PR Newswire)] Paradigm Therapeutics, Inc. announced that the first patient has been enrolled in its Phase III clinical trial evaluating SD-101 (ZorblesiaTM), an investigational topical cream for the treatment of chronic wounds and skin lesions associated with epidermolysis bullosa.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
