Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorate HaCaT Cell Photo-Aging

Researchers isolated exosomes derived from umbilical cord MSCs grown in a 3D culture system and explored their ability to modulate the photo-aging of HaCaT keratinocytes.
[Rejuvenation Research]
Liu, S.-J., Meng, M.-Y., Han, S., Gao, H., Zhao, Y.-Y., Yang, Y., Lin, Z.-Y., Yang, L.-R., Zhu, K., Han, R., Huang, W.-W., Wang, R.-Q., Yang, L.-L., Wang, W.-J., Li, L., Wang, X.-D., Hou, Z.-L., Liao, L. W., & Yang, L. (2021). Umbilical cord mesenchymal stem cell-derived exosomes ameliorate HaCaT cell photo-aging. Rejuvenation Research. https://doi.org/10.1089/rej.2020.2313 Cite
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Nuclear IL-33/SMAD Signaling Axis Promotes Cancer Development in Chronic Inflammation

Interleukin (IL)‐33 was highly expressed in the skin and pancreatic epithelial cells in chronic inflammation, leading to a markedly repressed Smad6 expression as well as dramatically upregulated p‐SMAD2/3 and p‐SMAD1/5 in the epithelial cells.
[EMBO Journal]
Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation | The EMBO Journal. (n.d.). Retrieved February 23, 2021, from https://www.embopress.org/doi/abs/10.15252/embj.2020106151 Cite
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Polycomb Complexes Redundantly Maintain Epidermal Stem Cell Identity during Development

Researchers showed how polycomb repressive complex 1 (PRC1) and PRC2 function as two independent counterparts, thereby providing a repressive safety net that protects and preserves lineage identity.
[Genes & Development]
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Dutch Consortium Investigates Biomarker to Identify Early-Stage Melanoma at High-Risk of Recurrence

SkylineDx announced a research collaboration with an academic hospital and a Dutch cancer registry to investigate patients with early-stage melanoma at high risk of disease-related fatality.
[SkylineDx, Inc.]
Cohen, I., Bar, C., Liu, H., Valdes, V. J., Zhao, D., Galbo, P. M., Silva, J. M., Koseki, H., Zheng, D., & Ezhkova, E. (2021). Polycomb complexes redundantly maintain epidermal stem cell identity during development. Genes & Development. https://doi.org/10.1101/gad.345363.120 Cite
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Polycomb Complexes Redundantly Maintain Epidermal Stem Cell Identity during Development

Coablation of polycomb repressive complex 1 (PRC1) and PRC2 in embryonic epidermal progenitors resulted in severe defects in epidermal stratification, a phenotype not observed in the single PRC1-null or PRC2-null epidermis.
[Genes & Development]
Cohen, I., Bar, C., Liu, H., Valdes, V. J., Zhao, D., Galbo, P. M., Silva, J. M., Koseki, H., Zheng, D., & Ezhkova, E. (2021). Polycomb complexes redundantly maintain epidermal stem cell identity during development. Genes & Development. https://doi.org/10.1101/gad.345363.120 Cite
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Spermidine-Induced Recovery of Human Dermal Structure and Barrier Function by Skin Microbiome

Treatment with secretions of S. pneumoniae and S. infantis induced the expression of genes associated with the formation of skin structure and the skin barrier function in human skin cells.
[Communications Biology]
Kim, G., Kim, M., Kim, M., Park, C., Yoon, Y., Lim, D.-H., Yeo, H., Kang, S., Lee, Y.-G., Beak, N.-I., Lee, J., Kim, S., Kwon, J. Y., Choi, W. W., Lee, C., Yoon, K. W., Park, H., & Lee, D.-G. (2021). Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome. Communications Biology, 4(1), 1–11. https://doi.org/10.1038/s42003-020-01619-4 Cite
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Ferris State University Pharmacy Associate Professor Awarded $377,805 Anticancer Drug Research Grant

Associate Professor of Medicinal Chemistry at Ferris State University, Dr. Sonali Kurup has learned the National Institutes of Health approved her proposal for $377,805 to fund an investigation into novel dual-targeted inhibitors of EGFR and aurora kinase. These enzymes contribute to uncontrolled cancer cell division and resistance to approved anticancer agents.
[Ferris State University]
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Autophagy Buffers Ras-Induced Genotoxic Stress Enabling Malignant Transformation in Keratinocytes Primed by Human Papillomavirus

Investigators showed that highly transforming mitogenic signals triggered by HRasG12V activity in E6E7–HPV–keratinocytes generated strong replication and oxidative stresses.
[Cell Death & Disease]
Yu, R., Longo, J., Leeuwen, J. E. van, Zhang, C., Branchard, E., Elbaz, M., Cescon, D. W., Drake, R. R., Dennis, J. W., & Penn, L. Z. (2021). Mevalonate pathway inhibition slows breast cancer metastasis via reduced N-glycosylation abundance and branching. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2642 Cite
Jones, C. J., Subramaniam, M., Emch, M. J., Bruinsma, E. S., Ingle, J. N., Goetz, M. P., & Hawse, J. R. (2021). Development and characterization of novel endoxifen-resistant breast cancer cell lines highlight numerous differences from tamoxifen-resistant models. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0872 Cite
Ramamoorthi, G., Kodumudi, K., Gallen, C., Zachariah, N. N., Basu, A., Albert, G., Beyer, A., Snyder, C., Wiener, D., Costa, R. L. B., & Czerniecki, B. J. (2021). Disseminated cancer cells in breast cancer: mechanism of dissemination and dormancy and emerging insights on therapeutic opportunities. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2021.02.004 Cite
Liu, T., Hooda, J., Atkinson, J. M., Whiteside, T. L., Oesterreich, S., & Lee, A. V. (2021). Exosomes in breast cancer - Mechanisms of Action and Clinical Potential. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0952 Cite
Broome, R., Chernukhin, I., Jamieson, S., Kishore, K., Papachristou, E. K., Mao, S.-Q., Tejedo, C. G., Mahtey, A., Theodorou, V., Groen, A. J., D’Santos, C., Balasubramanian, S., Farcas, A. M., Siersbæk, R., & Carroll, J. S. (2021). TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions. Cell Reports, 34(8). https://doi.org/10.1016/j.celrep.2021.108776 Cite
Broome, R., Chernukhin, I., Jamieson, S., Kishore, K., Papachristou, E. K., Mao, S.-Q., Tejedo, C. G., Mahtey, A., Theodorou, V., Groen, A. J., D’Santos, C., Balasubramanian, S., Farcas, A. M., Siersbæk, R., & Carroll, J. S. (2021). TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions. Cell Reports, 34(8). https://doi.org/10.1016/j.celrep.2021.108776 Cite
Zhang, Y., Xie, X., Yeganeh, P. N., Lee, D.-J., Valle-Garcia, D., Meza-Sosa, K. F., Junqueira, C., Su, J., Luo, H. R., Hide, W., & Lieberman, J. (2021). Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown. Proceedings of the National Academy of Sciences, 118(9). https://doi.org/10.1073/pnas.2022830118 Cite
Wigner, P., Zielinski, K., Labieniec-Watala, M., Marczak, A., & Szwed, M. (2021). Doxorubicin–transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Scientific Reports, 11(1), 4544. https://doi.org/10.1038/s41598-021-84146-4 Cite
De Luca, M., Romano, R., & Bucci, C. (2021). Role of the V1G1 subunit of V-ATPase in breast cancer cell migration. Scientific Reports, 11(1), 4615. https://doi.org/10.1038/s41598-021-84222-9 Cite
De Luca, M., Romano, R., & Bucci, C. (2021). Role of the V1G1 subunit of V-ATPase in breast cancer cell migration. Scientific Reports, 11(1), 4615. https://doi.org/10.1038/s41598-021-84222-9 Cite
Wang, M.-Y., Dean, E. D., Quittner-Strom, E., Zhu, Y., Chowdhury, K. H., Zhang, Z., Zhao, S., Li, N., Ye, R., Lee, Y., Zhang, Y., Chen, S., Yu, X., Leonard, D. C., Poffenberger, G., Deylen, A. V., McCorkle, S. K., Schlegel, A., Sloop, K. W., … Holland, W. L. (2021). Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets. Proceedings of the National Academy of Sciences, 118(9). https://doi.org/10.1073/pnas.2022142118 Cite
Wu, R., Li, K., Yuan, M., & Luo, K. Q. (2021). Nerve growth factor receptor increases the tumor growth and metastatic potential of triple-negative breast cancer cells. Oncogene, 1–17. https://doi.org/10.1038/s41388-021-01691-y Cite
Rodriguez, E., Boelaars, K., Brown, K., Eveline Li, R. J., Kruijssen, L., Bruijns, S. C. M., van Ee, T., Schetters, S. T. T., Crommentuijn, M. H. W., van der Horst, J. C., van Grieken, N. C. T., van Vliet, S. J., Kazemier, G., Giovannetti, E., Garcia-Vallejo, J. J., & van Kooyk, Y. (2021). Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9. Nature Communications, 12(1), 1270. https://doi.org/10.1038/s41467-021-21550-4 Cite
Morigny, P., Boucher, J., Arner, P., & Langin, D. (2021). Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics. Nature Reviews Endocrinology, 1–20. https://doi.org/10.1038/s41574-021-00471-8 Cite
Ávila-López, P. A., Guerrero, G., Nuñez-Martínez, H. N., Peralta-Alvarez, C. A., Hernández-Montes, G., Álvarez-Hilario, L. G., Herrera-Goepfert, R., Albores-Saavedra, J., Villegas-Sepúlveda, N., Cedillo-Barrón, L., Montes-Gómez, A. E., Vargas, M., Schnoor, M., Recillas-Targa, F., & Hernández-Rivas, R. (2021). H2A.Z overexpression suppresses senescence and chemosensitivity in pancreatic ductal adenocarcinoma. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01664-1 Cite
Funato, K., Smith, R. C., Saito, Y., & Tabar, V. (2021). Dissecting the impact of regional identity and the oncogenic role of human-specific NOTCH2NL in an hESC model of H3.3G34R-mutant glioma. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.02.003 Cite
Bressan, R. B., Southgate, B., Ferguson, K. M., Blin, C., Grant, V., Alfazema, N., Wills, J. C., Marques-Torrejon, M. A., Morrison, G. M., Ashmore, J., Robertson, F., Williams, C. A. C., Bradley, L., Kriegsheim, A. von, Anderson, R. A., Tomlinson, S. R., & Pollard, S. M. (2021). Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.01.016 Cite
Imtiaz, M. K. bin, Jaeger, B. N., Bottes, S., Machado, R. A. C., Vidmar, M., Moore, D. L., & Jessberger, S. (2021). Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.01.015 Cite
Ghosh, S., Liu, H., Yazdankhah, M., Stepicheva, N., Shang, P., Vaidya, T., Hose, S., Gupta, U., Calderon, M. J., Hu, M.-W., Nair, A. P., Weiss, J., Fitting, C. S., Bhutto, I. A., Gadde, S. G. K., Naik, N. K., Jaydev, C., Lutty, G. A., Handa, J. T., … Sinha, D. (2021). βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity. Communications Biology, 4(1), 1–19. https://doi.org/10.1038/s42003-021-01763-5 Cite
Colombo, A., Dinkel, L., Müller, S. A., Sebastian Monasor, L., Schifferer, M., Cantuti-Castelvetri, L., König, J., Vidatic, L., Bremova-Ertl, T., Lieberman, A. P., Hecimovic, S., Simons, M., Lichtenthaler, S. F., Strupp, M., Schneider, S. A., & Tahirovic, S. (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature Communications, 12(1), 1158. https://doi.org/10.1038/s41467-021-21428-5 Cite
Naskar, S., Qi, J., Pereira, F., Gerfen, C. R., & Lee, S. (2021). Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs. Cell Reports, 34(8). https://doi.org/10.1016/j.celrep.2021.108774 Cite
Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs: Cell Reports. (n.d.). Retrieved February 24, 2021, from https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00087-5 Cite
Andreassi, C., Luisier, R., Crerar, H., Darsinou, M., Blokzijl-Franke, S., Lenn, T., Luscombe, N. M., Cuda, G., Gaspari, M., Saiardi, A., & Riccio, A. (2021). Cytoplasmic cleavage of IMPA1 3′ UTR is necessary for maintaining axon integrity. Cell Reports, 34(8). https://doi.org/10.1016/j.celrep.2021.108778 Cite
Hasebe, M., & Shiga, S. (2021). Oviposition-promoting pars intercerebralis neurons show period-dependent photoperiodic changes in their firing activity in the bean bug. Proceedings of the National Academy of Sciences, 118(9). https://doi.org/10.1073/pnas.2018823118 Cite
Suazo, K. F., Jeong, A., Ahmadi, M., Brown, C., Qu, W., Li, L., & Distefano, M. D. (2021). Metabolic labeling with an alkyne probe reveals similarities and differences in the prenylomes of several brain-derived cell lines and primary cells. Scientific Reports, 11(1), 4367. https://doi.org/10.1038/s41598-021-83666-3 Cite
Liu, J. L., Patel, H. D., Haney, N. M., Epstein, J. I., & Partin, A. W. (2021). Advances in the selection of patients with prostate cancer for active surveillance. Nature Reviews Urology, 1–12. https://doi.org/10.1038/s41585-021-00432-w Cite
Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation | The EMBO Journal. (n.d.). Retrieved February 23, 2021, from https://www.embopress.org/doi/abs/10.15252/embj.2020106151 Cite
Essaouiba, A., Jellali, R., Shinohara, M., Scheidecker, B., Legallais, C., Sakai, Y., & Leclerc, E. (2021). Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment. Journal of Biotechnology. https://doi.org/10.1016/j.jbiotec.2021.02.009 Cite
Kim, D., Lee, S., & Na, K. (n.d.). Immune Stimulating Antibody-Photosensitizer Conjugates via Fc-Mediated Dendritic Cell Phagocytosis and Phototriggered Immunogenic Cell Death for KRAS-Mutated Pancreatic Cancer Treatment. Small, n/a(n/a), 2006650. https://doi.org/https://doi.org/10.1002/smll.202006650 Cite
Fan, Y., Hu, D., Li, D., Ma, C., Tang, Y., Tao, Q., Deng, L., & Tang, D. (2021). UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression. Clinical and Translational Oncology. https://doi.org/10.1007/s12094-021-02565-1 Cite
Sorrenson, B., Dissanayake, W. C., Hu, F., Lee, K. L., & Shepherd, P. R. (2021). A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion. Biochemical Journal, BCJ20200862. https://doi.org/10.1042/BCJ20200862 Cite
Assi, M., Achouri, Y., Loriot, A., Dauguet, N., Dahou, H., Baldan, J., Libert, M., Fain, J. S., Guerra, C., Bouwens, L., Barbacid, M., Lemaigre, F. P., & Jacquemin, P. (2021). Dynamic regulation of expression of KRAS and its effectors determines the ability to initiate tumorigenesis in pancreatic acinar cells. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2976 Cite
Terasaki, M., Takahashi, S., Nishimura, R., Kubota, A., Kojima, H., Ohta, T., Hamada, J., Kuramitsu, Y., Maeda, H., Miyashita, K., Takahashi, M., & Mutoh, M. (2021). A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells. Nutrition and Cancer, 0(0), 1–16. https://doi.org/10.1080/01635581.2020.1863994 Cite
Ma, X., Jain, N. M., Hitscherich, P., Seetamraju, S., & Lee, E. J. (2020). Stem Cell-Derived Insulin-Producing Cells in 3D Engineered Tissue in a Perfusion Flow Bioreactor. Tissue Engineering Part A. https://doi.org/10.1089/ten.tea.2020.0231 Cite
Immune Stimulating Antibody‐Photosensitizer Conjugates via Fc‐Mediated Dendritic Cell Phagocytosis and Phototriggered Immunogenic Cell Death for KRAS‐Mutated Pancreatic Cancer Treatment - Kim - - Small - Wiley Online Library. (n.d.). Retrieved February 23, 2021, from https://onlinelibrary.wiley.com/doi/10.1002/smll.202006650 Cite
Gerrits, E., Brouwer, N., Kooistra, S. M., Woodbury, M. E., Vermeiren, Y., Lambourne, M., Mulder, J., Kummer, M., Möller, T., Biber, K., Dunnen, W. F. A. den, De Deyn, P. P., Eggen, B. J. L., & Boddeke, E. W. G. M. (2021). Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease. Acta Neuropathologica. https://doi.org/10.1007/s00401-021-02263-w Cite
Gerrits, E., Brouwer, N., Kooistra, S. M., Woodbury, M. E., Vermeiren, Y., Lambourne, M., Mulder, J., Kummer, M., Möller, T., Biber, K., Dunnen, W. F. A. den, De Deyn, P. P., Eggen, B. J. L., & Boddeke, E. W. G. M. (2021). Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease. Acta Neuropathologica. https://doi.org/10.1007/s00401-021-02263-w Cite
Pease-Raissi, S. E., & Chan, J. R. (2021). Building a (w)rapport between neurons and oligodendroglia: reciprocal interactions underlying adaptive myelination. Neuron, 0(0). https://doi.org/10.1016/j.neuron.2021.02.003 Cite
Rodríguez Gil, Y., Jiménez Sánchez, P., Muñoz Velasco, R., García García, A., & Sánchez-Arévalo Lobo, V. J. (2021). Molecular Alterations in Pancreatic Cancer: Transfer to the Clinic. International Journal of Molecular Sciences, 22(4), 2077. https://doi.org/10.3390/ijms22042077 Cite
Venkat, S., Alahmari, A. A., & Feigin, M. E. (2021). Drivers of Gene Expression Dysregulation in Pancreatic Cancer. Trends in Cancer, 0(0). https://doi.org/10.1016/j.trecan.2021.01.008 Cite
Roper, S. J., Linke, F., Scotting, P. J., & Coyle, B. (2021). 3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination. Scientific Reports, 11(1), 4259. https://doi.org/10.1038/s41598-021-83809-6 Cite
Jin, J. W., Fan, X., del Cid-Pellitero, E., Liu, X.-X., Zhou, L., Dai, C., Gibbs, E., He, W., Li, H., Wu, X., Hill, A., Leavitt, B. R., Cashman, N., Liu, L., Lu, J., Durcan, T. M., Dong, Z., Fon, E. A., & Wang, Y. T. (2021). Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson’s disease models. Communications Biology, 4(1), 1–15. https://doi.org/10.1038/s42003-021-01746-6 Cite
Guo, M., Cui, C., Song, X., Jia, L., Li, D., Wang, X., Dong, H., Ma, Y., Liu, Y., Cui, Z., Yi, L., Li, Z., Bi, Y., Li, Y., Liu, Y., Duan, W., & Li, C. (2021). Deletion of FGF9 in GABAergic neurons causes epilepsy. Cell Death & Disease, 12(2), 1–13. https://doi.org/10.1038/s41419-021-03478-1 Cite
Kim, G., Kim, M., Kim, M., Park, C., Yoon, Y., Lim, D.-H., Yeo, H., Kang, S., Lee, Y.-G., Beak, N.-I., Lee, J., Kim, S., Kwon, J. Y., Choi, W. W., Lee, C., Yoon, K. W., Park, H., & Lee, D.-G. (2021). Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome. Communications Biology, 4(1), 1–11. https://doi.org/10.1038/s42003-020-01619-4 Cite
Cohen, I., Bar, C., Liu, H., Valdes, V. J., Zhao, D., Galbo, P. M., Silva, J. M., Koseki, H., Zheng, D., & Ezhkova, E. (2021). Polycomb complexes redundantly maintain epidermal stem cell identity during development. Genes & Development. https://doi.org/10.1101/gad.345363.120 Cite
Dong, Z., Yeo, K. S., Lopez, G., Zhang, C., Eggum, E. N. D., Rokita, J. L., Ung, C. Y., Levee, T. M., Her, Z. P., Howe, C. J., Hou, X., Ree, J. H. van, Li, S., He, S., Tao, T., Fritchie, K., Torres-Mora, J., Lehman, J. S., Meves, A., … Zhu, S. (2021). GAS7 Deficiency Promotes Metastasis in MYCN-driven Neuroblastoma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1890 Cite
Assi, M., Achouri, Y., Loriot, A., Dauguet, N., Dahou, H., Baldan, J., Libert, M., Fain, J. S., Guerra, C., Bouwens, L., Barbacid, M., Lemaigre, F. P., & Jacquemin, P. (2021). Dynamic regulation of expression of KRAS and its effectors determines the ability to initiate tumorigenesis in pancreatic acinar cells. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2976 Cite
EWI‐2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis - Fu - - Molecular Oncology - Wiley Online Library. (n.d.). Retrieved February 19, 2021, from https://febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.12930 Cite
Xu, H., Sheng, G., Lu, L., Wang, C., Zhang, Y., Feng, L., Meng, L., Min, P., Zhang, L., Wang, Y., & Han, F. (2021). GRPr-mediated photothermal and thermodynamic dual-therapy for prostate cancer with synergistic anti-apoptosis mechanism. Nanoscale. https://doi.org/10.1039/D0NR07196J Cite
Amoroso, F., Glass, K., Singh, R., Liberal, F., Steele, R. E., Maguire, S., Tarapore, R., Allen, J. E., Van Schaeybroeck, S., Butterworth, K. T., Prise, K., O’Sullivan, J. M., Jain, S., Waugh, D. J., & Mills, I. G. (2021). Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells. Scientific Reports, 11(1), 4252. https://doi.org/10.1038/s41598-021-83215-y Cite
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Biological Characteristics of Stem Cells Derived from Burned Skin-a Comparative Study with Umbilical Cord Stem Cells

Burn-derived MSCs- and umbilical cord-MSCs were compared using immunophenotyping, multi-lineage differentiation, seahorse analysis for glycolytic and mitochondrial function, immune surface markers, and cell secretion profile assays.
[Stem Cell Research & Therapy]
Dolp, R., Eylert, G., Auger, C., Aijaz, A., Chen, Y. A., Amini-Nik, S., Parousis, A., Datu, A.-K., & Jeschke, M. G. (2021). Biological characteristics of stem cells derived from burned skin—a comparative study with umbilical cord stem cells. Stem Cell Research & Therapy, 12(1), 137. https://doi.org/10.1186/s13287-021-02140-z Cite
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Mutations in the IFNγ-JAK-STAT Pathway Causing Resistance to Immune Checkpoint Inhibitors in Melanoma Increase Sensitivity to Oncolytic Virus Treatment

Cytotoxicity experiments were performed with a number of oncolytic viruses on a matched melanoma cell line pair generated from a baseline biopsy and a progressing lesion with complete JAK2 loss from a patient that relapsed on anti-PD-1 therapy, in melanoma lines following JAK1/2 RNAi and pharmacological inhibition and in Jak2 KO B16-F10 mouse melanomas.
[Clinical Cancer Research]
Nguyen, T.-T., Ramsay, L., Ahanfeshar-Adams, M., Lajoie, M., Schadendorf, D., Alain, T., & Watson, I. R. (2021). Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3365 Cite
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Functional Hair Follicle Regeneration: An Updated Review

Scientists review potential cell sources with hair follicle (HF)-inducive capacities and summarize current bioengineering strategies for HF regeneration with functional restoration.
[Signal Transduction and Targeted Therapy]
Ji, S., Zhu, Z., Sun, X., & Fu, X. (2021). Functional hair follicle regeneration: an updated review. Signal Transduction and Targeted Therapy, 6(1), 1–11. https://doi.org/10.1038/s41392-020-00441-y Cite
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