Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

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TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2-Mediated Glycolysis in Keratinocytes

August 17, 2026

[Advanced Science] Investigators identify Toll-interacting protein (TOLLIP) as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism.

Failed Metabolic Adaptation to Stress Contributes to Epidermal Cell Adhesion Defects in Darier Disease

August 17, 2026

[Science Advances] Researchers explored how extra-genetic factors, particularly metabolic and oxidative stress, influence Darier disease, showing that impaired antioxidant defenses can compromise SERCA2 function and weaken epidermal cell adhesion.

Fibroblasts Resist Staphylococcus aureus on the Skin Surface by Responding to Interleukin-1 and Recruiting Neutrophils

August 17, 2026

[Science Advances] Using unbiased transcriptomic, biochemical, and phosphoproteomic analyses, followed by targeted validation in human and mouse models, investigators found that fibroblast recognition of interleukin-1 is essential for immune response.

Screening Cross-Injury Responses in Skin Organoids Identifies a THBS2-Enriched Pro-Repair Fibroblast State during Regeneration

August 17, 2026

[Journal of Advanced Research] Scientists established a high-fidelity mouse skin organoid platform to simulate clinically relevant stressors and identify the core regulatory components of the regenerative program.

MICAL2 As a Key Effector of β-catenin Signaling Driving Melanoma Progression and Therapeutic Resistance

August 17, 2026

[Cell Death & Differentiation] The authors demonstrate that activation of β-catenin is associated with a poor prognosis in melanoma. This conclusion was based on immunohistochemical analysis of a cohort of 157 patients and the identification of a genetic signature for melanoma upon β-catenin activation.

Metabolism Alterations Accompany the Invasive Phenotype of Melanoma Cells Resistant to BRAF/MEK Inhibitors

August 17, 2026

[Biochimica Et Biophysica Acta-Molecular Cell Research] Researchers showed that melanoma cells resistant to BRAF (B-raf serine-threonine-protein kinase)/MEK (mitogen-activated protein kinase kinase)inhibitors undergo metabolic rewiring that supports a more invasive phenotype, linking therapy resistance with altered glycolysis, mitochondrial function, and lipid metabolism.

Ferroptosis in Vitiligo and Melanoma: Opposing Susceptibilities, Shared Mechanisms, and Therapeutic Targets

August 17, 2026

[Experimental Cell Research] Scientists highlight the contrasting roles of ferroptosis in vitiligo and melanoma, revealing shared mechanisms that could be exploited for melanocyte-specific therapeutic strategies.

UBC Medicine Researchers Awarded More Than $39 Million in CIHR Funding

August 17, 2026

[The University of British Columbia] UBC Faculty of Medicine researchers have been awarded more than $39 million in federal funding through the Canadian Institutes of Health Research (CIHR) Project Grant: Spring 2026 competition.

$1 Million Grant Fuels Research on Precise Cancer Radiation

August 14, 2026

[University of Missouri School of Medicine] Researchers from the University of Missouri School of Medicine recently received a $1 million grant from the National Institutes of Health to study the latest technology in cancer research.

Gli2-Serpinh1 Drives Fibroblast State Transition during Skin Wound Healing

July 20, 2026

[NPJ Regenerative Medicine] By integrating single-cell RNA-sequencing, spatial transcriptomics, and in vivo and in vitro analyses in both mouse and skin organoid models for functional validation, investigators identified a previously underappreciated Gli2–Serpinh1 regulatory axis that plays a key role in fibroblast state transitions during skin wound healing.

V-ATPase-Targeted siRNA Library Screening Reveals ATP6V1A Negatively Regulates UVB-Induced Keratinocyte Senescence

July 20, 2026

[Biology Direct] Scientists showed that ATP6V1A protects against UVB-induced skin cell senescence by preserving lysosomal function and autophagy, identifying a potential target for combating photoaging.

PRMT5 Promotes Psoriatic Inflammation through Mediating Dimethylation of P65 in Keratinocytes

July 20, 2026

[Molecular Medicine] Researchers showed that targeting PRMT5 suppresses psoriasis by destabilizing p65 and dampening inflammatory signaling in keratinocytes.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.