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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Tattooed Human In Vitro Skin Model for Testing the Biocompatibility of Tattoo Inks and Healing Progression after Tattooing
[Scientific Reports] Researchers described an in vitro 3D human skin model that was tattooed with black and red ink. Biocompatibility including analysis of cytotoxicity, gene expression patterns of proinflammatory cytokines, and proliferation markers were investigated over a period of seven days.
S1PR3-Driven Positive Feedback Loop Sustains STAT3 Activation and Keratinocyte Hyperproliferation in Psoriasis
[Cell Death & Disease] The authors identifed sphingosine-1-phosphate receptor 3 (S1PR3) as a critical regulator of STAT3 activation and psoriasis pathogenesis, orchestrating a self-amplifying circuit that sustained keratinocyte hyperproliferation and chronic inflammation.
Role of The Androgen Receptor in Melanoma Aggressiveness
[Cell Death & Disease] By combining different experimental approaches, scientists observed that melanoma escape was mediated by the androgen-triggered shedding of the surface molecule MICA.
The Role of Multiomics in Revealing the Mechanism of Skin Repair and Regeneration
[Frontiers In Pharmacology] While genomic studies identify the genetic basis of wound healing, transcriptomics and proteomics uncover the dynamic changes in gene and protein expression, and metabolomics provides a snapshot of metabolic alterations associated with wound healing.
SenPred: A Single-Cell RNA Sequencing-Based Machine Learning Pipeline to Classify Deeply Senescent Dermal Fibroblast Cells for the Detection of an In Vivo Senescent Cell...
[Genome Medicine] Scientists presented SenPred, a machine-learning pipeline which identified fibroblast senescence based on single-cell transcriptomics from fibroblasts grown in 2D and 3D.
Glycobiology of Psoriasis: A Review
[Journal of Autoimmunity] The authors summarize relevant literature on psoriasis-related glycans to help clarify the potential molecular mechanisms of psoriasis and identify novel biomarkers and targets for the treatment of psoriasis.
Efficacy and Tolerability of Neoadjuvant Therapy with Talimogene Laherparepvec in Cutaneous Basal Cell Carcinoma: A Phase II Trial (NeoBCC Trial)
[Nature Cancer] Investigators presented a single-arm, Phase II, neoadjuvant trial with the oncolytic virus talimogene laherparepvec in 18 patients with difficult-to-resect cutaneous basal cell carcinomas.
Human Hair Follicle Mesenchymal Stem Cell-Derived Exosomes Attenuate UVB-Induced Photoaging via the miR-125b-5p/TGF-β1/Smad Axis
[Biomaterials Research] The authors revealed that exosomes derived from human hair follicle mesenchymal stem cells effectively enhanced the migration and proliferation of human dermal fibroblasts (HDFs) and upregulated the expressions of TGF-β1, p-Smad2/p-Smad3, collagen type 1, and collagen type 3.
The Adaptor Protein Miro1 Modulates Horizontal Transfer of Mitochondria in Mouse Melanoma Models
[Cell Reports] Researchers showed the role of Miro1 in horizontal mitochondrial transfer in mouse melanoma models in vivo and its involvement with tunneling nanotubes.
Screening the Human miRNA Interactome Reveals Coordinated Up-Regulation in Melanoma, Adding Bidirectional Regulation to miRNA Networks
[Science Advances] Researchers demonstrated coordinated up-regulation of functionally coupled proteins by miRNA. They focused on CD98 heavy chain (CD98hc), the heavy chain of the amino acid transporter LAT-1, and α-2,3-sialyltransferases ST3GAL1 and ST3GAL2, which were critical for CD98hc stability in melanoma.
Controlled Delivery of MTX from Thermosensitive Hydrogels Using Au Nanorods for Enhanced Therapeutics of Psoriasis via Improving Stratum Corneum Penetration
[Small] Scientists developed a near-infrared (NIR) light-responsive thermosensitive hydrogel-based drug reservoir. The in vitro anti-psoriasis experiment indicated that, gold nanorods, as photothermal cores of composite hydrogel, not only triggered keratinocyte apoptosis but also promoted methotrexate release in a synergistic manner.
Y2O3NPs Induce Selective Cytotoxicity, Genomic Instability, Oxidative Stress, and ROS Mediated Mitochondrial Apoptosis in Human Epidermoid Skin A-431 Cancer Cells
[Scientific Reports] The authors investigated the impact of Y2O3NPs on both human skin normal and cancer cells, with an emphasis on assessing their cytotoxicity, genotoxicity, and the mechanisms underlying these effects.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
