CD276 Expression Enables Squamous Cell Carcinoma Stem Cells to Evade Immune Surveillance

The authors showed that cancer stem cells upregulated the immune checkpoint molecule CD276 to evade host immune responses.
[Cell Stem Cell]
Wang, C., Li, Y., Jia, L., Kim, J. koo, Li, J., Deng, P., Zhang, W., Krebsbach, P. H., & Wang, C.-Y. (2021). CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.04.011 Cite
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Discovery of a Novel RORγ Antagonist with Skin-Restricted Exposure for Topical Treatment of Mild to Moderate Psoriasis

To alleviate the potential safety concerns, identifying compounds with skin-restricted exposure amenable for topical use was of great interest.
[Scientific Reports]
Liu, S., Liu, D., Shen, R., Li, D., Hu, Q., Yan, Y., Sun, J., Zhang, F., Wan, H., Dong, P., Feng, J., Zhang, R., Li, J., Zhang, L., & Tao, W. (2021). Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis. Scientific Reports, 11(1), 9132. https://doi.org/10.1038/s41598-021-88492-1 Cite
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High Sensitivity Sanger Sequencing Detection of BRAF Mutations in Metastatic Melanoma FFPE Tissue Specimens

Scientists showed that Sanger sequencing using the NuProbe VarTrace BRAF assay, based on the Blocker Displacement Amplification (BDA) technology, is capable of detecting BRAF V600 mutations down to 0.20% VAF from FFPE lymph node tissue samples.
[Scientific Reports]
Cheng, L. Y., Haydu, L. E., Song, P., Nie, J., Tetzlaff, M. T., Kwong, L. N., Gershenwald, J. E., Davies, M. A., & Zhang, D. Y. (2021). High sensitivity sanger sequencing detection of BRAF mutations in metastatic melanoma FFPE tissue specimens. Scientific Reports, 11(1), 9043. https://doi.org/10.1038/s41598-021-88391-5 Cite
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A Unique Mode of Keratinocyte Death Requires Intracellular Acidification

Researchers found that upper stratum granulosum cell death was preceded by prolonged (∼60 min) Ca2+ elevation and rapid induction of intracellular acidification.
[Proceedings of the National Academy of Sciences of the United States of America]
Matsui, T., Kadono-Maekubo, N., Suzuki, Y., Furuichi, Y., Shiraga, K., Sasaki, H., Ishida, A., Takahashi, S., Okada, T., Toyooka, K., Sharif, J., Abe, T., Kiyonari, H., Tominaga, M., Miyawaki, A., & Amagai, M. (2021). A unique mode of keratinocyte death requires intracellular acidification. Proceedings of the National Academy of Sciences, 118(17). https://doi.org/10.1073/pnas.2020722118 Cite
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Staphylococcus cohnii Is a Potentially Biotherapeutic Skin Commensal Alleviating Skin Inflammation

Scientists found that Tmem79−/− mice spontaneously develop interleukin-17-producing T-cell-driven skin inflammation. Comparative skin microbiome analysis revealed that the disease activity index is negatively associated with S. cohnii.
[Cell Reports]
Ito, Y., Sasaki, T., Li, Y., Tanoue, T., Sugiura, Y., Skelly, A. N., Suda, W., Kawashima, Y., Okahashi, N., Watanabe, E., Horikawa, H., Shiohama, A., Kurokawa, R., Kawakami, E., Iseki, H., Kawasaki, H., Iwakura, Y., Shiota, A., Yu, L., … Honda, K. (2021). Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation. Cell Reports, 35(4). https://doi.org/10.1016/j.celrep.2021.109052 Cite
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Teva Announces the Launch of the First Generic Version of Absorica® (isotretinoin) Capsules, for the Treatment of Severe Recalcitrant Nodular Acne in Patients 12 Years of Age and Older, in the United States

Teva Pharmaceuticals, Inc. announced its launch of the first available 10 mg, 20 mg, 25 mg, 30 mg, 35 mg and 40 mg strength generic version of Absorica®1 capsules for the treatment of severe recalcitrant nodular acne in non-pregnant patients 12 years of age and older with multiple inflammatory nodules with a diameter of 5 mm or greater.
[Teva Pharmaceuticals, Inc. (Business Wire, Inc.)]
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ITIH5, a p53-Responsive Gene, Inhibits the Growth and Metastasis of Melanoma Cells by Downregulating the Transcriptional Activity of KLF4

Scientists found that the expression of ITIH5 was decreased in melanoma tissues compared with normal skin tissues.
[Cell Death & Disease]
Liu, J., Cao, F., Li, X., Zhang, L., Liu, Z., Li, X., Lin, J., & Han, C. (2021). ITIH5, a p53-responsive gene, inhibits the growth and metastasis of melanoma cells by downregulating the transcriptional activity of KLF4. Cell Death & Disease, 12(5), 1–15. https://doi.org/10.1038/s41419-021-03707-7 Cite
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Volar Location and Degree of Pigmentation Are Associated with Poor Survival and First Metastasis Pattern in Acral Melanoma

Researchers evaluated patient demographics, stages, clinicopathological features, anatomic site of melanoma including nail versus volar surface, and degree of melanoma pigmentations, sentinel lymph node biopsy results, and the first metastasis sites.
[Pigment Cell & Melanoma Research]
Ryu, G. W., Choi, Y. D., Jin, S., Chung, I.-J., Shin, M.-H., & Yun, S. J. (n.d.). Volar location and degree of pigmentation are associated with poor survival and first metastasis pattern in acral melanoma. Pigment Cell & Melanoma Research, n/a(n/a). https://doi.org/https://doi.org/10.1111/pcmr.12983 Cite
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Comprehensive Analysis of DNA Damage Repair in Squamous Cell Carcinoma Subtypes

Investigators characterized the molecular profile of squamous cell carcinoma by developing a classification system based on DNA damage repair gene expression profiles.
[Life Sciences]
Comprehensive analysis of DNA damage repair in squamous cell carcinoma subtypes. (2021). Life Sciences, 278, 119559. https://doi.org/10.1016/j.lfs.2021.119559 Cite
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BNIP3 Promotes HIF-1α-Driven Melanoma Growth by Curbing Intracellular Iron Homeostasis

Scientists found that BNIP3‐deprived melanoma cells displayed increased intracellular iron levels caused by heightened NCOA4‐mediated ferritinophagy, which fostered PHD2‐mediated HIF‐1α destabilization.
[EMBO Journal]
Vara-Pérez, M., Rossi, M., Van den Haute, C., Maes, H., Sassano, M. L., Venkataramani, V., Michalke, B., Romano, E., Rillaerts, K., Garg, A. D., Schepkens, C., Bosisio, F. M., Wouters, J., Oliveira, A. I., Vangheluwe, P., Annaert, W., Swinnen, J. V., Colet, J. M., van den Oord, J. J., … Agostinis, P. (2021). BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis. The EMBO Journal, n/a(n/a), e106214. https://doi.org/10.15252/embj.2020106214 Cite
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Hydrogel Containing (1 → 6)-β-D-Glucan (Lasiodiplodan) Effectively Promotes Dermal Wound Healing

β-glucan was studied as a healing biomaterial that has not hitherto been reported in the scientific literature. LAS produced by the ascomycete Lasiodiplodia theobromae MMPI was used in the formulation of a healing hydrogel.
[International Journal of Biological Macromolecules]
Hydrogel containing (1 → 6)-β-D-glucan (lasiodiplodan) effectively promotes dermal wound healing. (2021). International Journal of Biological Macromolecules, 183, 316–330. https://doi.org/10.1016/j.ijbiomac.2021.04.169 Cite
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