Amyloid Aggregates Accumulate in Melanoma Metastasis Modulating YAP Activity

Using secretome analyses, the authors revealed the extracellular accumulation of amyloidogenic proteins, i.e. premelanosome protein, in metastatic melanoma, together with proteins that assist amyloid maturation into fibrils.
[EMBO Reports]
Matafora, V., Farris, F., Restuccia, U., Tamburri, S., Martano, G., Bernardelli, C., Sofia, A., Pisati, F., Casagrande, F., Lazzari, L., Marsoni, S., Bonoldi, E., & Bachi, A. (2020). Amyloid aggregates accumulate in melanoma metastasis modulating YAP activity. EMBO Reports, n/a(n/a), e50446. https://doi.org/10.15252/embr.202050446 Cite
Full ArticleGraphical Abstract

Continue reading “Amyloid Aggregates Accumulate in Melanoma Metastasis Modulating YAP Activity”

Bookmark

No account yet? Register

0
Share

Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
Press Release

Continue reading “Twitter Account of Embattled #MeTooSTEM Founder Suspended”

Bookmark

No account yet? Register

0
Share

Emerging Role of FBXO22 in Carcinogenesis

Scientists summarize the regulatory factors and downstream targets of F-box protein 22 (FBXO22) in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
Cheng, J., Lin, M., Chu, M., Gong, L., Bi, Y., & Zhao, Y. (2020). Emerging role of FBXO22 in carcinogenesis. Cell Death Discovery, 6(1), 1–7. https://doi.org/10.1038/s41420-020-00303-0 Cite
Full Article

Continue reading “Emerging Role of FBXO22 in Carcinogenesis”

Bookmark

No account yet? Register

0
Share

Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model

Researchers used CRISPR-Cas9 gene targeting to generate a library of 3D organotypic skin tissues that selectively differed in their capacity to produce glycan structures on the main types of N- and O-linked glycoproteins and glycolipids. This tissue library revealed distinct changes in skin formation associated with a loss of features for all tested glycoconjugates.
[Developmental Cell]
Full ArticleGraphical Abstract

Continue reading “Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model”

Bookmark

No account yet? Register

1+
Share

Small Extracellular Vesicles Containing miR-381-3p from Keratinocytes Promotes Th1/Th17 Polarization in Psoriasis

Investigators proposed that psoriatic keratinocytes transferred miR-381-3p to CD4 + T cells via small extracellular vesicles, inducing Th1/Th17 polarization and promoting psoriasis development.
[Journal of investigative Dermatology]
Abstract

Continue reading “Small Extracellular Vesicles Containing miR-381-3p from Keratinocytes Promotes Th1/Th17 Polarization in Psoriasis”

Bookmark

No account yet? Register

0
Share

Co-Loading of Finasteride and Baicalin in Phospholipid Vesicles Tailored for the Treatment of Hair Disorders

Finasteride was loaded in phospholipid vesicles and baicalin was co-loaded as an adjuvant. Their effect on hair growth was evaluated in vitro and in vivo.
[Nanoscale]
AbstractGraphical Abstract

Continue reading “Co-Loading of Finasteride and Baicalin in Phospholipid Vesicles Tailored for the Treatment of Hair Disorders”

Bookmark

No account yet? Register

0
Share

Plasma Treatment Limits Cutaneous Squamous Cell Carcinoma Development In Vitro and In Vivo

Using the kINPen argon plasma jet, a selective growth-reducing action of plasma treatment was identified in two squamous cell carcinoma cell lines in 2D and 3D cultures.
[Cancers]
Full Article

Continue reading “Plasma Treatment Limits Cutaneous Squamous Cell Carcinoma Development In Vitro and In Vivo

Bookmark

No account yet? Register

0
Share

Signaling of Tumor-Derived sEV Impacts Melanoma Progression

The authors feature melanoma cell-derived exosomes with special emphasis on exosome-mediated signaling between melanoma cells and the host immune system.
[International Journal of Molecular Sciences]
Full Article

Continue reading “Signaling of Tumor-Derived sEV Impacts Melanoma Progression”

Bookmark

No account yet? Register

0
Share

Checkmate Pharmaceuticals Granted FDA Fast Track Designation for CMP-001 Combined with PD-1 Blockade in the Treatment of Certain Types of Metastatic or Unresectable Melanoma

Checkmate Pharmaceuticals, Inc. announced that the FDA granted Fast Track designation to its product candidate, CMP-001, in combination with a programmed death receptor 1 (PD-1) blocking antibody for initial treatment of patients with unresectable stage III or stage IV melanoma; and treatment of patients with unresectable or metastatic melanoma refractory to prior anti-PD-1 blockade.
[Checkmate Pharmaceuticals (BusinessWire, Inc.)]
Press Release

Continue reading “Checkmate Pharmaceuticals Granted FDA Fast Track Designation for CMP-001 Combined with PD-1 Blockade in the Treatment of Certain Types of Metastatic or Unresectable Melanoma”

Bookmark

No account yet? Register

0
Share

The CDK4/6-EZH2 Pathway Is a Potential Therapeutic Target for Psoriasis

Delineation of the pathway revealed that CDK4/6 phosphorylated EZH2 in keratinocytes, thereby triggering a methylation-induced activation of STAT3.
[Journal of Clinical Investigation]
Müller, A., Dickmanns, A., Resch, C., Schäkel, K., Hailfinger, S., Dobbelstein, M., Schulze-Osthoff, K., & Kramer, D. (2020). The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI134217 Cite
AbstractGraphical Abstract

Continue reading “The CDK4/6-EZH2 Pathway Is a Potential Therapeutic Target for Psoriasis”

Bookmark

No account yet? Register

0
Share

French Science Bill Promises Boost to Public R&D

The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider]
Press Release

Continue reading “French Science Bill Promises Boost to Public R&D”

Bookmark

No account yet? Register

0
Share
Share