Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

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Fatty Acid Oxidation Fuels Mitochondrial Respiration to Drive Epidermal Stem Cell Fate and Differentiation

August 31, 2026

[Nature Communications] Researchers revealed that early mitochondrial reprogramming, characterized by the activation of oxidative phosphorylation, is a determinant of differentiation initiation.

SNHG26 Orchestrates Pro-Fibrotic Fibroblast Maintenance via PTBP1-Mediated Alternative Polyadenylation of AKT3 in Dermal Fibrosis

August 31, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified a previously unrecognized RNA-based mechanism that maintains pathogenic fibroblast states during skin fibrosis.

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids-Containing Biopatch Enables Functional Skin Regeneration

August 31, 2026

[Advanced Healthcare Materials] Investigators presented a 3D embedded bioprinting strategy for engineering vascularized biopatches through the precise integration of prevascularized multicellular spheroids within a skin-derived decellularized extracellular matrix bioink.

CaMK4 Drives Pathogenic Th17 Cell Response via the STAT3/RORγT Axis in Psoriasis

August 31, 2026

[Cell Death Discovery] Researchers showed that CaMK4 was highly expressed in CD4⁺ T cells from psoriatic lesional skin in both humans and mice.

Plasminogen Activator Inhibitor-1 Promotes the Proliferation and Blocks TGF-β1-Dependent Growth Inhibition of Cholesteatoma Keratinocytes by ERK Signaling

August 31, 2026

[European Archives of Oto-Rhino-Laryngology] Scientists examined the role of PAI-1 plays in the pathophysiology of cholesteatoma and investigated how TGF-β1 and PAI-1 interact to regulate keratinocyte proliferation.

The FOXQ1/SSBP2 Regulatory Axis Drives Malignant Progression of Melanoma

August 31, 2026

[Molecular Carcinogenesis] The authors identified novel molecular targets associated with melanoma progression. Consensus clustering analysis revealed three melanoma subtypes, with the C3 subtype exhibiting the worst prognosis.

Single-Cell Profiling Reveals an XBP1s-Associated ER Proteostasis State Linked to Metastatic Stress Adaptation in Melanoma

August 31, 2026

[Cellular Signalling] Using single-cell RNA sequencing in a B16 melanoma model, researchers identified a metastasis-enriched endoplasmic reticulum-stress tumor state characterized by increased Xbp1 regulon activity.

Recent Advances in Genetically Engineered Mouse Models of Melanoma: Insights Into Tumor Initiation and Oncogenic Signaling Pathways

August 31, 2026

[International Journal of Stem Cells] Scientists summarizes the recent advances in melanoma genetically engineered mouse models, highlights the oncogenic signaling pathways active in these systems, and discusses the molecular insights derived from these models regarding melanoma initiation, progression, and intratumoral diversity.

Melanoma mRNA Vaccine Shows Promise in Preventing Disease Recurrence

August 31, 2026

[Moffitt Cancer Center ] New research from Phase III trial finds personalized intismeran plus pembrolizumab may better prevent high-risk melanoma recurrence after surgery.

New KWF Funding Boosts 8 CCA Cancer Research Projects

August 21, 2026

[Amsterdam UMC] KWF announced 34 research projects that will receive funding in its latest round — including 8 projects involving Cancer Center Amsterdam (CCA) researchers.

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2-Mediated Glycolysis in Keratinocytes

August 17, 2026

[Advanced Science] Investigators identify Toll-interacting protein (TOLLIP) as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism.

Failed Metabolic Adaptation to Stress Contributes to Epidermal Cell Adhesion Defects in Darier Disease

August 17, 2026

[Science Advances] Researchers explored how extra-genetic factors, particularly metabolic and oxidative stress, influence Darier disease, showing that impaired antioxidant defenses can compromise SERCA2 function and weaken epidermal cell adhesion.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.