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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Sex-Dependent Effects in the Aged Melanoma Tumor Microenvironment Influence Invasion and Resistance to Targeted Therapy
[Cell] Scientists reported that aged male fibroblasts selectively drove an invasive, therapy-resistant phenotype in melanoma cells and promoted metastasis in aged male mice by increasing AXL expression.
Jagged-1+ Skin Tregs Modulate Cutaneous Wound Healing
[Scientific Reports] Using a tamoxifen inducible Foxp3creERT2Jag1fl/fl model, the authors showed that loss of functional Jag1 in regulatory T cells significantly delayed the rate of full-thickness wound closure.
The Use of Ectopic Volar Fibroblasts to Modify Skin Identity
[Science] Researchers used primary cultured volar (sole) or nonvolar (scalp) fibroblasts from healthy volunteers to test for distinctive responses to pressure, capacity for modifying skin identity in bioprints, and potential cell therapy through autologous engraftment of fibroblasts in a clinical trial.
A Water-Soluble Caveolin-1 Peptide Inhibits Psoriasis-Like Skin Inflammation by Suppressing Cytokine Production and Angiogenesis
[Scientific Reports] To understand the activities of caveolin-1 (CAV-1) scaffolding domain subregions on psoriasis, researchers evaluated their beneficial effects on tissue morphology in the imiquimod model and the molecular mechanisms underlying these effects.
FGF12 Positively Regulates Keratinocyte Proliferation by Stabilizing MDM2 and Inhibiting p53 Activity in Psoriasis
[Advanced Materials] In vitro RNA sequencing demonstrated that knockdown of fibroblast growth factor 12 (FGF12) effectively arrested the cell cycle, inhibited cell proliferation, and predominantly regulated the p53 signaling pathway.
Phosphodiesterase 4 Is Overexpressed in Keloid Epidermal Scars and Its Inhibition Reduces Keratinocyte Fibrotic Alterations
[Molecular Medicine] Using in vitro and in vivo experiments, researchers explored the specific role of phosphodiesterase 4 (PDE4B) in epidermal remodeling and hypertrophy seen in skin fibrosis.
Effect of 3-Hydrazinylquinoxaline-2-Thiol Hydrogel on Skin Wound Healing Process in Diabetic Rats
[Scientific Reports] Scientists topically tested the wound healing effect of 3-hydrazinylquinoxaline-2-thiol hydrogel in a full-thickness excision wound in streptozotocin-induced type 1 diabetic rats.
Single-Cell RNA Sequencing Reveals Melanoma Cell State-Dependent Heterogeneity of Response to MAPK Inhibitors
[eBioMedicine] Investigators applied single-cell RNA sequencing to interrogate the molecular features of immunotherapy-naive and immunotherapy-resistant melanoma tumours in response to ex vivo BRAF/MEK inhibitor treatment.
Diterpenoid DGT Alleviates Atopic Dermatitis–Like Responses In Vitro and In Vivo via Targeting IL-4Rα
[Biomedicine & Pharmacotherapy] Researchers observed anti-inflammatory effects of DGT on tumor necrosis factor-α/interferon-γ–treated human keratinocytes, and anti-allergic effects on immunoglobulin E–sensitized bone marrow–derived mast cells.
TRPM7 Controls Skin Keratinocyte Senescence by Targeting Intracellular Calcium Signaling
[FEBS Journal] TRPM7 promoted skin keratinocyte senescence by triggering intracellular calcium transfer from the endoplasmic reticulum to the mitochondria; accumulation of mitochondrial calcium then induced a drop in mitochondrial membrane potential and reactive oxygen species production, leading to subsequent nuclear enlargement and DNA damage.
A Degradable Bioelectronic Scaffold for Localized Cell Transfection toward Enhancing Wound Healing in a 3D Space
[Advanced Materials] Scientists developed an implantable bioelectronics that enabled the synchronization of the three stages of wound healing, offering accelerated and high-quality healing of large skin wounds.
Type I Interferon Signaling Induces Melanoma Cell-Intrinsic PD-1 and Its Inhibition Antagonizes Immune Checkpoint Blockade
[Nature Communications] Researchers demonstrated induction of PD-1 in melanoma cells via type I interferon receptor (IFNAR) signaling and reversal of immune checkpoint blockade efficacy through IFNAR pathway inhibition.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
