Category Archives: Dermal Cell

Dermal Cell News is an online publication and email newsletter highlighting the latest research about wound healing, skin disorders, and dermal cancers.
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As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.

VYNE Therapeutics Announces Phase Ib Data for FMX114 from Phase Ib/IIa Trial for the Treatment of Mild-to-Moderate Atopic Dermatitis

VYNE Therapeutics, Inc. announced that it has completed the Phase Ib portion of a Phase Ib/IIa clinical trial evaluating FMX114 for the treatment of mild-to-moderate atopic dermatitis
[VYNE Therapeutics, Inc.]
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Trehangelins Ameliorate Inflammation-Induced Skin Senescence by Suppressing the Epidermal YAP-CCN1 Axis

Researchers described a possible mechanism involved in skin aging focusing on the effect of Trehangelins on epidermal cellular communication metwork factor 1 (CCN1).
[Scientific Reports]
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Discrimination of Hand-Foot Skin Reaction Caused by Tyrosine Kinase Inhibitors Based on Direct Keratinocyte Toxicity and Vascular Endothelial Growth Factor Receptor-2 Inhibition

The authors explained the incidence of hand-foot skin reaction in patients treated with tyrosine kinase inhibitors by focusing on keratinocyte toxicity and inhibition of vascular endothelial growth factor receptor, which played an essential role in angiogenesis.
[Biochemical Pharmacology]
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Therapeutic Downregulation of Neuronal PAS Domain 2 (Npas2) Promotes Surgical Skin Wound Healing

The hit compound (Dwn1) suppressed circadian Npas2 expression, increased murine dermal fibroblast cell migration, and decreased collagen synthesis in vitro.
[eLife]
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The Effect of a Static Magnetic Field and Baicalin or Baicalein Interactions on Amelanotic Melanoma Cell Cultures (C32)

The authors evaluated the simultaneous exposure of melanoma cells to flavones and the static magnetic fields that were generated by permanent magnets on the gene expression and the activity of the antioxidant enzymes that were associated with the antioxidant defense system.
[Molecular Biology Reports]
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Reduced Expression of Collagen 17A1 in Naturally Aged, Photoaged, and UV-Irradiated Human Skin In Vivo: Potential Links to Epidermal Aging

Researchers found that matrix metalloproteinases were responsible for ultraviolet (UV)-mediated Collagen 17A degradation in both in vitro keratinocytes and in vivo mouse skin.
[Journal of Cell Communication and Signaling]
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BRAF Inhibitors Reprogram Cancer-Associated Fibroblasts to Drive Matrix Remodeling and Therapeutic Escape in Melanoma

BRAF inhibitor induced BRAF-CRAF heterodimerization and subsequent activation of ERK signaling in cancer-associated fibroblasts, leading to inactivation of the β-catenin destruction complex.
[Cancer Research]
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Decursin Prevents Melanogenesis by Suppressing MITF Expression through the Regulation of PKA/CREB, MAPKs, and PI3K/Akt/GSK-3β Cascades

Decursin exhibited no cytotoxicity and significantly reduced intracellular tyrosinase activity and melanin content in B16F10 melanoma cells.
[Biomedicine & Pharmacotherapy]
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KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia

Investigators demonstrated that Kelch-like protein 24 (KLHL24) played a role in hair maintenance by regulating the cytoskeleton structure of hair follicle stem cells (HFSCs) and highlighted the importance of the ubiquitin-proteasome system in the stability of HFSCs.
[Journal of Investigative Dermatology]
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TSLP Impairs Epidermal Barrier Integrity by Stimulating the Formation of Nuclear IL-33/Phosphorylated STAT3 Complex in Human Keratinocytes

Researchers stimulated post-confluent human keratinocytes and living skin equivalent with TSLP to investigate the role of nuclear IL-33 in TSLP-induced epidermal barrier defects.
[Journal of Investigative Dermatology]
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Advances in the Pathogenesis of Psoriasis: From Keratinocyte Perspective

The authors review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions.
[Cell Death & Disease]
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