Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

Myc-Dependent Dedifferentiation of Gata6+ Epidermal Cells Resembles Reversal of Terminal Differentiation

[Nature Cell Biology] Researchers integrated lineage tracing and single-cell mRNA sequencing to uncover the underlying mechanism of Gata6+ epidermal cells dedifferentiation.

Impact of Exposure to Atmospheric Particulate Matter in Human Skin-Derived Fibroblast Cells: A Metabolomics Approach for the Class of Amino Acids Based on GC×GC-Q-TOFMS/MS

[Journal of Hazardous Materials] The toxicity of particulate material to fibroblast cells derived from the human dermis was investigated using metabolomic analysis for the class of amino acids.

Loss of Dicer in Newborn Melanocytes Leads to Premature Hair Greying and Changes in Integrin Expression

[Journal of Investigative Dermatology] Using two mouse genetic models and human and mouse cell lines, the authors found that the inactivation of Dicer in melanocytes led to a misplacement of these cells within the hair follicle.

Fisetin, a Potential Skin Rejuvenation Drug That Eliminates Senescent Cells in the Dermis

[Biogerontology] Researchers investigated the effects of fisetin, a potential anti-aging component found in various edible fruits and vegetables, on senescent human dermal fibroblasts and aging human skin.

Depletion of G9A Attenuates Imiquimod-Induced Psoriatic Dermatitis via Targeting EDAR-NF-κB Signaling in Keratinocyte

[Cell Death & Disease] Scientists found that G9A was highly expressed in lesions of patients with psoriasis and imiquimod-induced psoriasis-like mouse model.

Melanoma Cells Repress Desmoglein 1 in Keratinocytes to Promote Tumor Cell Migration

[Journal of Cell Biology] Investigators provided evidence that melanoma cells hijacked intercellular communications by secreting factors that keep Desmoglein 1 expression low in the surrounding keratinocytes.

4-Octyl Itaconate Inhibits Inflammation to Attenuate Psoriasis as an Agonist of Oxeiptosis

[International Immunopharmacology] Scientists found that oxeiptosis of keratinocytes was inhibited in psoriasis lesions. KEAP1, as the upstream molecular component of oxeiptosis, was highly expressed in psoriasis lesions.

Increase of ISG15 in Psoriasis Lesions and Its Promotion of Keratinocyte Proliferation via the Hif-1α Signaling Pathway

[Experimental Dermatology] The expression of interferon stimulated gene 15 (ISG15) saw a significant increase through the immunohistochemical detection of imiquimod-induced mice. In the psoriasis cell model, a remarkable increase also occurred.

Selective Adhesion Inhibition and Hyaluronan Envelope Reduction of Dermal Tumor Cells by Cold Plasma-Activated Medium

[Cell Adhesion & Migration] Researchers conducted a comparative study concerning the plasma sensitivity of dermal tumor cells versus non-tumorigenic dermal cells regarding their adhesion capacity.

Skin Cancer Prevention – Recent Advances and Unmet Challenges

[Cancer Letters] Investigators review the epidemiology, risk factors, and current cutaneous squamous cell carcinoma (cSCC) prevention strategies. They highlight the gaps and future clinical strategies to address cSCC risk in high-risk populations.

EBGLYSS® (Lebrikizumab) Receives Positive CHMP Opinion for Moderate-to-Severe Atopic Dermatitis

[Almirall, S.A.] Almirall S.A. announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency issued a positive opinion recommending the marketing authorization of EBGLYSS for the treatment of adult and adolescent patients with moderate-to-severe atopic dermatitis, who are candidates for systemic therapy.

Sustained Pigmentation Causes DNA Damage and Invokes Translesion Polymerase Polκ for Repair in Melanocytes

[Nucleic Acids Research] Researchers systematically investigated the effect of sustained elevation of melanogenesis and mapped the consequent cellular repair response of melanocytes.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.