Genome Researchers Question Security Provisions in New US Senate Bill

Buried in a bill approved by the US Senate to help the United States compete with China is language that is drawing fire from human genome researchers. It would require the NIH to develop new security protocols aimed at preventing the misuse of US-funded genomic data by China and other nations.
[Science]
Editorial
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Istari Oncology Announces FDA Granted Fast Track Designation to PVSRIPO for the Treatment of Advanced Melanoma

Istari Oncology, Inc., announced that the US FDA has granted Fast Track designation to PVSRIPO for the improved survival in patients with advanced melanoma who have disease progression after anti-PD-1/anti-PD-L1 therapy.
[Istari Oncology, Inc. (BusinessWire, Inc.)]
Press Release
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Tracing the Origin of Hair Follicle Stem Cells

Investigators combined marker-independent long-term 3D live imaging and single-cell transcriptomics to capture a dynamic lineage progression and transcriptome changes in the entire epithelium of the mouse hair follicle as it developed.
[Nature]
Morita, R., Sanzen, N., Sasaki, H., Hayashi, T., Umeda, M., Yoshimura, M., Yamamoto, T., Shibata, T., Abe, T., Kiyonari, H., Furuta, Y., Nikaido, I., & Fujiwara, H. (2021). Tracing the origin of hair follicle stem cells. Nature, 1–6. https://doi.org/10.1038/s41586-021-03638-5 Cite
Abstract
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miR-24 Controls the Regenerative Competence of Hair Follicle Progenitors by Targeting Plk3

Researchers explored how the intrinsic sensitivity of skin hair follicle (HF) progenitors to growth stimuli was dynamically regulated. They discovered miR-24 was an miRNA whose expression in HF progenitors inversely correlated with their growth potency in vivo.
[Cell Reports]
Liu, F., Zhang, X., Peng, Y., Zhang, L., Yu, Y., Hua, P., Zhu, P., Yan, X., Li, Y., & Zhang, L. (2021). miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3. Cell Reports, 35(10). https://doi.org/10.1016/j.celrep.2021.109225 Cite
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Skin Protein-Derived Peptide-Conjugated Vesicular Nanocargos for Selected Skin Cell Targeting and Consequent Activation

Investigators selectively conjugated several skin protein-derived cell-targeting peptides, including KTTKS, NAP-amide, and Lam332, to amphiphilic polymer-reinforced lipid nanovesicles to specifically target fibroblasts, melanocytes, and keratinocytes, respectively, through effective association with the corresponding cell membrane receptors.
[Journal of Materials Chemistry B]
Cho, J. H., Kang, J. Y., Kim, S., Baek, H. R., Kim, J., Jang, K.-S., & Kim, J. W. (2021). Skin protein-derived peptide-conjugated vesicular nanocargos for selected skin cell targeting and consequent activation. Journal of Materials Chemistry B. https://doi.org/10.1039/D1TB00935D Cite
Abstract
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Novel Induction of CD40 Expression by Tumor Cells with RAS/RAF/PI3K Pathway Inhibition Augments Response to Checkpoint Blockade

Rigosertib monotherapy or in combination therapy with immune checkpoint blockade were investigated using immunocompetent mouse models of BRAFwt and BRAFmut melanoma and analyzed in reference to patient data.
[Molecular Cancer]
Yan, C., Saleh, N., Yang, J., Nebhan, C. A., Vilgelm, A. E., Reddy, E. P., Roland, J. T., Johnson, D. B., Chen, S.-C., Shattuck-Brandt, R. L., Ayers, G. D., & Richmond, A. (2021). Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade. Molecular Cancer, 20(1), 85. https://doi.org/10.1186/s12943-021-01366-y Cite
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Dual Covalent Inhibition of PKM and IMPDH Targets Metabolism in Cutaneous Metastatic Melanoma

Scientists identified a drug, HA344, that concomitantly targets two distinct metabolic hubs in cancer cells.
[Cancer Research]
Zerhouni, M., Martin, A. R., Furstoss, N., Gutierrez, V. S., Jaune, E., Tekaya, N., Beranger, G. E., Abbe, P., Regazzetti, C., Amdouni, H., Driowya, M., Dubreuil, P., Luciano, F., Jacquel, A., Tulic, M. K., Cluzeau, T., O’Hara, B. P., Ben-Sahra, I., Passeron, T., … Rocchi, S. (2021). Dual covalent inhibition of PKM and IMPDH targets metabolism in cutaneous metastatic melanoma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2114 Cite
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Inhibitory Effect of Saccharomyces cerevisiae Extract Obtained through Ultrasound-Assisted Extraction on Melanoma Cells

Ultrasound-assisted extract of yeast was found to effectively inhibit melanoma cell growth and proliferation as well as the expression of cyclin D1 and c-myc, in vitro.
[Ultrasonics Sonochemistry]
Inhibitory effect of Saccharomyces cerevisiae extract obtained through ultrasound-assisted extraction on melanoma cells. (2021). Ultrasonics Sonochemistry, 76, 105620. https://doi.org/10.1016/j.ultsonch.2021.105620 Cite
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Phase I/II Clinical Trial of Adoptive Cell Transfer of Sorted Specific T Cells for Metastatic Melanoma Patients

Scientists reported results from a phase I/II clinical trial in which six metastatic HLA-A2 melanoma patients received autologous antigen-specific T-cells produced from peripheral blood mononuclear cells, after peptide stimulation in vitro, followed by sorting with HLA-peptide multimers and amplification.
[Cancer Immunology Immunotherapy]
Dréno, B., Khammari, A., Fortun, A., Vignard, V., Saiagh, S., Beauvais, T., Jouand, N., Bercegay, S., Simon, S., Lang, F., & Labarrière, N. (2021). Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-021-02961-0 Cite
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Epidermal Stem Cells Maintain Stemness via a Biomimetic Micro/Nanofiber Scaffold That Promotes Wound Healing by Activating the Notch Signaling Pathway

To inhibit the differentiation of epidermal stem cells (EpSCs) and maintain their stemness, scientists developed an electrospun polycaprolactone + cellulose acetate micro/nanofiber for the culture and transplantation of EpSCs.
[Stem Cell Research & Therapy]
Lin, Z., Zhao, C., Lei, Z., Zhang, Y., Huang, R., Lin, B., Dong, Y., Zhang, H., Li, J., & Li, X. (2021). Epidermal stem cells maintain stemness via a biomimetic micro/nanofiber scaffold that promotes wound healing by activating the Notch signaling pathway. Stem Cell Research & Therapy, 12(1), 341. https://doi.org/10.1186/s13287-021-02418-2 Cite
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Suppressive Role of microRNA-130b-3p in Ferroptosis in Melanoma Cells Correlates with DKK1 Inhibition and Nrf2-HO-1 Pathway Activation

Researchers identified whether and how miR-130b-3p regulated ferroptosis in melanoma cells. Melanoma cells were treated with erastin or RSL3 to mimic ferroptosis in vitro.
[Human Cell]
Liao, Y., Jia, X., Ren, Y., Deji, Z., Gesang, Y., Ning, N., Feng, H., Yu, H., & Wei, A. (2021). Suppressive role of microRNA-130b-3p in ferroptosis in melanoma cells correlates with DKK1 inhibition and Nrf2-HO-1 pathway activation. Human Cell. https://doi.org/10.1007/s13577-021-00557-5 Cite
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