Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Melatonin and the Skin: Current Progress and Perspectives for Human Health
[Journal of Investigative Dermatology] Metabolic pathways, together with receptor- and nonreceptor-mediated phenotypic activities of its intermediates, have been identified as a cutaneous melatoninergic system. Pharmacological modulation of melatonin or its metabolites may be used to treat cutaneous disorders and aging.
Progress on Mitochondria and Hair Follicle Development in Androgenetic Alopecia: Relationships and Therapeutic Perspectives
[Stem Cell Research & Therapy] The authors summarize the connection between mitochondrial dysfunction and hair follicle development, outline the links between diseases related to mitochondrial disorders and hair issues, and highlight the influence of mitochondrial dysfunction on androgenetic alopecia.
CD4 Expression Controls Epidermal Stem Cell Balance
[Scientific Reports] Using CD4 knockout mice, scientists demonstrated that CD4 expression was essential for maintaining fast-cycling epidermal stem cells during homeostasis and that CD4 loss mitigated the age-related decline in wound repair capacity.
Combined Inhibition of Focal Adhesion Kinase and RAF/MEK Elicits Synergistic Inhibition of Melanoma Growth and Reduces Metastases
[Cell Reports Medicine] Utilizing mouse models that mimic human melanoma brain metastases, researchers investigated the necessity of focal adhesion kinase in the development of distant metastases and its potential as a therapeutic target.
Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma
[Cancer Immunology Research] To identify tumor-intrinsic modulators of immunity to melanoma, investigators performed a whole-genome CRISPR screen in melanoma and identified Setdb1 as well as all components of the human silencing hub complex.
Dermata Expands Patent Portfolio with Issuance of New US Patent for Next-Generation Acne Treatment
[Dermata Therapeutics, Inc. (BioSpace)] Dermata Therapeutics, Inc. announced issuance by the US Patent and Trademark Office of a new patent for its XYNGARIâ„¢ product candidate for the treatment of acne.
Selective Abrogation of S6K2 Identifies Lipid Homeostasis as a Survival Vulnerability in MAPK Inhibitor–Resistant NRAS-Mutant Melanoma
[Science Translational Medicine] Scientists reported that selectively silencing the ribosomal protein S6 kinase (S6K) 2 while preserving the activity of S6K1 perturbed lipid metabolism and triggerd lethal lipid peroxidation in NRASMUT melanoma cells that were resistant to MAPK inhibition.
Phase II Open-Label Trial of Brentuximab Vedotin with Pembrolizumab in PD-1–Pretreated Metastatic Non–Small Cell Lung Cancer and Metastatic Cutaneous Melanoma
[Clinical Cancer Research] Investigators evaluated responses to brentuximab vedotin (BV)+ pembrolizumab after PD-1 therapy and explored corresponding biomarkers. A total of 58 patients with metastatic cutaneous melanoma received ≥1 dose of BV + pembrolizumab.
Enhanced HDR-Mediated Correction of Heterozygous COL7A1 Mutations for Recessive Dystrophic Epidermolysis Bullosa
[Molecular Therapy - Nucleic Acids] Scientists developed a highly efficient and versatile gene editing strategy for recessive dystrophic epidermolysis bullosa that incorporated the small molecule inhibitor M3814 to enhance homology-directed repair (HDR).
Zika Virus Modulates Human Fibroblasts to Enhance Transmission Success in a Controlled Lab-Setting
[Communications Biology] Researchers showed that Zika virus immediately altered gene/protein expression patterns in infected-dermal fibroblasts, altering their metabolism to increase the release of mosquito-attractive volatile organic compounds, which improved its transmission success.
PARP4 Deficiency Enhances Sensitivity to ATM Inhibitor by Impairing DNA Damage Repair in Melanoma
[Cell Death Discovery] Scientists revealed that poly (ADP-ribose) polymerase 4 (PARP4) played a role in double-strand break repair by regulating the non-homologous end joining pathway through its involvement in Ku80 mono-ADP-ribosylation.
ZBP1-Mediated PANoptosis Is a Crucial Lethal Form in Diverse Keratinocyte Death Modalities in UVB-Induced Skin Injury
[Cell Death & Disease] Investigators observed that the key molecules of GSDMD-mediated pyroptosis, apoptosis, and necroptosis, which were N-terminal GSDMD, cleaved caspase-3/PARP, and phosphorylated MLKL, respectively, were elevated in keratinocytes of UVB-challenged mice and human skin tissue.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.