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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Clustering of RNA Co-Expression Network Identifies Novel Long Non-Coding RNA Biomarkers in Squamous Cell Carcinoma
[Scientific Reports] Scientists conducted RNA sequencing of patient derived cutanoue squamous cell carcinoma (cSCC) cell lines and normal human epidermal keratinocytes and uncovered a novel set of lncRNAs implicated in cSCC cell locomotion.
Flexible Sono–Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling
[ACS Nano] Researchers developed a flexible sono–piezo patch that aimed to create an endogenous regenerative microenvironment to promote the repair of sweat glands in burn wounds. This patch utilized low-intensity pulsed ultrasound to activate electrical stimulation of the target tissue, resulting in enhanced pro-regenerative behaviors of niche tissues and cells, including peripheral nerves, fibroblasts, and vasculatures.
Polysaccharide Hydrogels for Skin Wound Healing
[Heliyon] Scientists review the use of polysaccharide hydrogels in the context of wound-healing applications, including hemostatic effects, antimicrobial activities, anti-inflammatory properties, and promotion of angiogenesis.
IL-12 and PD-1 Peptide Combination Gene Therapy for the Treatment of Melanoma
[Molecular Therapy] Researchers designed peptides and plasmids encoding the mouse homologs of the pembrolizumab and nivolumab programmed cell death 1 ligand 1 (PD-L1) binding regions. The mouse homolog to pembrolizumab was effective at blocking PD-1/PD-L1 in vitro.
Biochemical Role of FOXM1-Dependent Histone Linker H1B in Human Epidermal Stem Cells
[Cell Death & Disease] Leveraging single-cell transcriptomic data, investigators explored the FOXM1-dependent biochemical signals controlling self-renewal and differentiation in epidermal stem cells aimed at improving regenerative medicine applications.
Loss of Lamin A Leads to the Nuclear Translocation of AGO2 and Compromised RNA Interference
[Nucleic Acids Research] Researchers discovered that reduced lamin A levels significantly induced nuclear influx of AGO2 in SHSY5Y neuroblastoma and A375 melanoma cancer cell lines, which normally have no nuclear AGO2.
Skin-on-a-Chip Technologies towards Clinical Translation and Commercialization
[Biofabrication] Scientists review the most recent advances in the design and applications of skin-on-a-chip platforms (SoC) for disease modeling as well as the analysis of drugs and cosmetics. They also identify the existing obstacles that hinder the advancement of SoC platforms, proposing directions for future improvements.
Innovative Melanoma Treatment among NCInnovation’s $5.2 Million Research Funding Recipients
[Dermatology Times] NCInnovation announced the approval of $5.2 million in research funding for eight research projects at seven North Carolina public universities. Projects recently approved include multi-year vaccine development, neuro drug delivery system, and melanoma research.
Synthetic RIG-I Agonist-Mediated Cancer Immunotherapy Synergizes with MAP-Kinase Inhibition against BRAF Mutated Melanoma
[Molecular Therapy - Nucleic Acids] Investigators reported that the clinically relevant combination of MAP kinase pathway inhibitors Dabrafenib and Trametinib synergized with RIG-I agonist-induced immunotherapy to kill BRAF-mutated human and mouse melanoma cells.
Appendage-Resident Epithelial Cells Expedite Wound Healing Response in Adult Zebrafish
[Current Biology] Scientists reported an unexpected role of adult zebrafish appendages (fins) in accelerating the re-epithelialization process. Through whole-body monitoring of single-cell dynamics in live animals, they found that fin-resident epithelial cells (FECs) were highly mobile and migrated to cover wounds in nearby body regions.
Determinants of Resistance and Response to Melanoma Therapy
[Nature Cancer] The authors discuss the determinants of melanoma tumor heterogeneity, mechanisms of therapy resistance and effective therapy regimens that hold curative promise.
The Mechano-Chemical Circuit in Fibroblasts and Dendritic Cells Drives Basal Cell Proliferation in Psoriasis
[Cell Reports] By employing mouse psoriasis and skin organoid models, investigators discovered a mechano-chemical signaling pathway that originated from dendritic cells, extended to dermal fibroblasts, and ultimately enhanced basal cell proliferation in psoriatic skin.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
