Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Subscribe|Follow Us On
Blocking CCR1 Macrophages Overcomes Resistance to Immune Checkpoint Inhibitors in Melanoma
[Cell Communication and Signaling] Scientists explored the role of chemokine signaling pathways in melanoma immunotherapy.
A Novel Microfluidic System for 3D Epidermis and Full-Thickness Skin Growth for Nanoparticle Safety Assessment
[Advanced Healthcare Materials] Investigators presented a novel skin-on-chip model with dynamic perfusion and a modular architecture suitable for epidermis-only and full-thickness skin models.
Targeting LAG3 to Alter the Tumor Immune Reactivity of CD8+T Cells Is a Potential Therapy for Skin Cutaneous Melanoma
[Scientific Reports] Scientists revealed the functional heterogeneity of CD8+ T cells in skin cutaneous melanoma and demonstrated that lymphocyte activation gene 3 (LAG3) inhibition suppresses tumor proliferation and metastasis.
CircSipa1l1 Modulates Melanoma Cell Differentiation by Activating the IGF2BP1-ARHGDIB Axis and ERK Signaling Pathway
[Journal of Translational Medicine] Investigators revealed that circSipa1l1 acts as an oncogenic circRNA by regulating the IGF2BP1/ARHGDIB/ERK axis in melanoma, suggesting it could be a potential therapeutic target for melanoma differentiation therapy.
Prostaglandin D2 Axis Impairs Immunity against Melanoma via Dendritic Cells and γδ T Cells in Middle-Aged Mice
[The Journal of Immunology] Researchers showed that the absence of PLA2G2D or the PGD2 receptor, PTGDR, restricts primary tumor growth and lung metastasis of subcutaneously implanted melanoma, as demonstrated using middle-aged Pla2g2d−/− and Ptgdr−/− mice.
Epigenetic Regulatory Mechanisms of Autoimmune Skin Diseases: Novel Biomarkers and Therapeutic Prospects
[Clinical Epigenetics] The authors synthesize recent evidence elucidating the central role of three core epigenetic mechanisms, DNA methylation, histone modifications, and noncoding RNAs, in driving autoimmune skin disease pathogenesis.
The Role of Mast Cells in Skin Aging: Mechanisms and Therapeutic Advances
[Experimental Dermatology] Mast cells engage in pathological crosstalk with fibroblasts, keratinocytes, melanocytes and immune cells, establishing self-perpetuating feedback loops that amplify aging-related processes.
Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma That Drives Antitumor Immunity
[Cancer Research] Researchers performed single-cell RNA sequencing on mouse melanomas experiencing successful and unsuccessful immune responses and discovered a prominent ferroptosis signature in tumors undergoing immune-mediated regression.
Medicus Pharma Ltd. Announces Collaboration with the Gorlin Syndrome Alliance to Pursue Compassionate Use Pathway for Skinject™ in Patients with Gorlin Syndrome
[Medicus Pharma, Ltd.] Medicus Pharma, Ltd. announced a strategic collaboration with the Gorlin Syndrome Alliance to advance compassionate access to SKINJECT™, the Company’s investigational doxorubicin containing microneedle arrays for patients suffering from Gorlin Syndrome, also known as nevoid basal cell carcinoma syndrome.
LINC01198 Activates Hippo Signaling to Stimulate IL-1β Autocrine for Driving Vemurafenib Resistance by Associating with TAOK1/2 in Melanoma
[Cell Death Discovery] Scientists established vemurafenib-resistance melanoma cell strain together with acute vemurafenib treatment and characterized LINC01198 as the only one LncRNA up-regulated in both of stable vemurafenib-resistant and acute vemurafenib-treated melanoma cells.
Molecular Glue Degrader Function of SPOP Enhances STING-Dependent Immunotherapy Efficacy in Melanoma Models
[Journal of Clinical Investigation] Scientists revealed that SPOP targeted the innate immune sensor STING for degradation in a CK1γ phosphorylation-dependent manner to promote melanoma growth.
Subclinical Fields of BRAF V600E-Mutant Melanocytes Populate Human Skin and Are Enriched Around Melanoma and Naevi
[British Journal of Dermatology] The authors identified BRAF V600E-mutant melanocytes in skin surrounding naevi and primary melanomas, even years after tumour excision. Fields
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
