Investigators devised a strategy to enhance maturation of otic progenitor cells toward human hair cell–like cells by assembling 3D otic organoids that contain human pluripotent stem cell-derived otic cells, endothelial cells, and mesenchymal stem cells.
[Cell and Tissue Research]
6445212 42M39MMT items 1 apa default asc 1
By tracking cell lineages over multiple days, researchers established that these cells indeed proliferated more than neighboring cells, thus establishing that rapid signaling reactivation predicts long-term vemurafenib resistance.
6445212 F8XMXNVF items 1 apa default asc 1
Genetic variation in MC1R is a main determinant of red hair color phenotype and confers susceptibility to skin disorders. Scientists assessed the effects and function of MC1R variants identified in our clinical cohort of 135,947 participants with available exome sequencing using phenome-wide association scan
[Genetics in Medicine]
6445212 KHTMPEQM items 1 apa default asc 1
Through a combination of in vitro assays, mouse models, and intravital imaging, scientists found that S. aureus immune evasion in skin was controlled by a cascade composed of the ArlRS two-component regulatory system and its downstream effector, MgrA.
6445212 HKKGJACJ items 1 apa default asc 1
Researchers identified fermitin family member 2 as a potential target in A375 cell line by siRNA library screening. They also validated the tumor suppressive role of kindlin-2 was validated in vitro and in vivo.
6445212 7XK5R5AB items 1 apa default asc 1
SIRT7 has evoked an interest in the study of hair follicle stem cells, but its role in melanin synthesis remains unclear. Investigators developed SIRT7 gene knock out melanoma cells using the CRISPR/Cas9 system.
[Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease]
6445212 ZJ96U53U items 1 apa default asc 1
Severe injuries to skin including hypodermis require full-thickness skin replacement. Researchers bio-engineered a tri-layered human skin substitute containing the epidermis, dermis, and hypodermis.
6445212 27J64SST items 1 apa default asc 1
The authors evaluated the effects of cannabidiol, a phytocannabinoid known for its antioxidant and anti-inflammatory properties, on the proteome of keratinocyte membranes exposed to hydrogen peroxide.
6445212 TU8NWUVQ items 1 apa default asc 1
Researchers investigated the effect of the 3D-fibroblast dermis on the expression of tight junction (TJ)-related proteins and TJ function in layer-by-layer-3D Skin.
[ACS Biomaterials Science & Engineering]
6445212 DKSVWH7K items 1 apa default asc 1
Scientists ran an assay using five human papillomavirus (HPV)-negative head and neck squamous cell carcinoma cell lines cultured on the human tumor-derived matrix Myogel.
6445212 DMT2GRBH items 1 apa default asc 1
Increased autoantigen presentation by HLA molecules, cross-activation of pathogen-induced T cells against autologous structures, altered metabolism of self-proteins, and excessive production of proinflammatory signals may all contribute to the breakdown of immune tolerance and the development of autoimmune skin diseases.
[Journal of Investigative Dermatology]
6445212 F8JRUMC6 items 1 apa default asc 1