Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

Ovol1/2 Loss-Induced Epidermal Defects Elicit Skin Immune Activation and Alter Global Metabolism

[EMBO Reports] The authors demonstrated that inducible and simultaneous ablation of transcription factor-encoding Ovol1 and Ovol2 in adult epidermis results in barrier dysregulation through impacting epithelial-mesenchymal plasticity and inflammatory gene expression.

Wound Infiltrating Adipocytes Are Not Myofibroblasts

[Nature Communications] Using genetic lineage tracing and live imaging in explants and in wounded animals, the authors observed that injury induced a transient migratory state in adipocytes with vastly distinct cell migration patterns and behaviors from fibroblasts.

A Comprehensive Signature Based on Endoplasmic Reticulum Stress-Related Genes in Predicting Prognosis and Immunotherapy Response in Melanoma

[Scientific Reports] Scientists validated that silencing the expression of RAC1 could restrain the proliferation and migration, promote apoptosis, as well as increase the expression of PD-1/PD-L1 and CTLA4 in melanoma cells.

FAM3C/ILEI Protein Is Elevated in Psoriatic Lesions and Triggers Psoriasiform Hyperproliferation in Mice

[EMBO Molecular Medicine] Mechanistically, ILEI triggered Erk and Akt signaling, which then activated STAT3 via Ser727 phosphorylation. Keratinocyte-specific ILEI deletion ameliorated TPA-induced skin inflammation.

mTORC1 Activity Negatively Regulates Human Hair Follicle Growth and Pigmentation

[EMBO Reports] Investigators used healthy, organ-cultured human scalp hair follicles to interrogate the role of mTORC1 in a prototypic human (mini-)organ.

Patient-Derived Melanoma Organoid Models Facilitate the Assessment of Immunotherapies

[Ebiomedicine] Researchers report two different methods for generating melanoma patient-derived organoids, one which was embedded in collagen gel, and the other which was inlaid in Matrigel.

In Vitro Effects of Undifferentiated Callus Extracts from Plantago major L, Rhodiola rosea L and Silybum marianum L in Normal and Malignant Human Skin...

[Heliyon] The anti-inflammatory and antioxidant activity of undifferentiated callus extracts from Plantago major L, Rhodiola rosea L, and Silybum marianum L was investigated both in normal and malignant skin cells.

MicroRNA-205 Promotes Hair Regeneration by Modulating Mechanical Properties of Hair Follicle Stem Cells

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors showed that hair follicle stem cells in the bulge were stiff with high actomyosin contractility and resistance to size change, whereas hair germ progenitors were soft and periodically enlarged and contracted during quiescence

CCN1 Is Predominantly Elevated in Human Skin Dermis by Solar-Simulated Ultraviolet Irradiation and Accumulated in Dermal Extracellular Matrix

[Journal Of Cell Communication And Signaling] Researchers explored the functionality of the matrix-bound CCN1 by culturing dermal fibroblasts on an acellular matrix plate that was enriched with a high concentration of CCN1.

Chemokines As Possible Therapeutic Targets in Metastatic Melanoma

[Cancer Medicine] The authors focus on the role of chemokines in melanoma and possible therapeutic strategies to alter chemokine activation and subsequently inhibit the activation of signaling cascades that may promote metastasis.

Cooperation of TGF-β and FGF Signaling Pathways in Skin Development

[Cell Proliferation] Scientists provide evidence of the role of TGF-β and fibroblast growth factor (FGF) signaling pathways in the development of different skin layers, especially the disparate dermis of different body regions.

Breakthrough Treatments for Accelerated Wound Healing

[Science Advances] The authors summarize advances in the development of novel drug, biologic products, and biomaterial therapies for wound healing for marketed therapies and those in clinical trials.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.