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Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
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YTHDF2 Regulates Self Non-Coding RNA Metabolism to Control Inflammation and Tumorigenesis
[Nature Communications] Researchers show that m6A-methylated self U6 snRNA is recognized by YTHDF2 to reduce its stability and prevent its binding to Toll-like receptor 3 (TLR3), leading to decreased inflammatory responses in human and mouse cells and mouse models.
MC1R Determines Healing Outcomes in Acute and Chronic Cutaneous Wounds
[Proceedings of the National Academy of Sciences of the United States of America] Scientists establish the MC1R/POMC axis as a fundamental regulator of skin repair and identify promising therapeutic strategies to drive healing.
Piwil-2 Represents a Poor Prognosticator in Merkel Cell Carcinomas That Regulates Oncoproteins, Cell Cycle Arrest, and SOX-2 Expression
[Scientific Reports] Investigators utilized siRNAs for Piwil-2 knock-down in Merkel cell carcinoma cells. Downregulation of Piwil-2 caused a significant change of 202 different PIWI-interacting RNAs and 419 proteins.
Blocking CCR1 Macrophages Overcomes Resistance to Immune Checkpoint Inhibitors in Melanoma
[Cell Communication and Signaling] Scientists explored the role of chemokine signaling pathways in melanoma immunotherapy.
A Novel Microfluidic System for 3D Epidermis and Full-Thickness Skin Growth for Nanoparticle Safety Assessment
[Advanced Healthcare Materials] Investigators presented a novel skin-on-chip model with dynamic perfusion and a modular architecture suitable for epidermis-only and full-thickness skin models.
Targeting LAG3 to Alter the Tumor Immune Reactivity of CD8+T Cells Is a Potential Therapy for Skin Cutaneous Melanoma
[Scientific Reports] Scientists revealed the functional heterogeneity of CD8+ T cells in skin cutaneous melanoma and demonstrated that lymphocyte activation gene 3 (LAG3) inhibition suppresses tumor proliferation and metastasis.
CircSipa1l1 Modulates Melanoma Cell Differentiation by Activating the IGF2BP1-ARHGDIB Axis and ERK Signaling Pathway
[Journal of Translational Medicine] Investigators revealed that circSipa1l1 acts as an oncogenic circRNA by regulating the IGF2BP1/ARHGDIB/ERK axis in melanoma, suggesting it could be a potential therapeutic target for melanoma differentiation therapy.
Prostaglandin D2 Axis Impairs Immunity against Melanoma via Dendritic Cells and γδ T Cells in Middle-Aged Mice
[The Journal of Immunology] Researchers showed that the absence of PLA2G2D or the PGD2 receptor, PTGDR, restricts primary tumor growth and lung metastasis of subcutaneously implanted melanoma, as demonstrated using middle-aged Pla2g2d−/− and Ptgdr−/− mice.
Epigenetic Regulatory Mechanisms of Autoimmune Skin Diseases: Novel Biomarkers and Therapeutic Prospects
[Clinical Epigenetics] The authors synthesize recent evidence elucidating the central role of three core epigenetic mechanisms, DNA methylation, histone modifications, and noncoding RNAs, in driving autoimmune skin disease pathogenesis.
The Role of Mast Cells in Skin Aging: Mechanisms and Therapeutic Advances
[Experimental Dermatology] Mast cells engage in pathological crosstalk with fibroblasts, keratinocytes, melanocytes and immune cells, establishing self-perpetuating feedback loops that amplify aging-related processes.
Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma That Drives Antitumor Immunity
[Cancer Research] Researchers performed single-cell RNA sequencing on mouse melanomas experiencing successful and unsuccessful immune responses and discovered a prominent ferroptosis signature in tumors undergoing immune-mediated regression.
Medicus Pharma Ltd. Announces Collaboration with the Gorlin Syndrome Alliance to Pursue Compassionate Use Pathway for Skinject™ in Patients with Gorlin Syndrome
[Medicus Pharma, Ltd.] Medicus Pharma, Ltd. announced a strategic collaboration with the Gorlin Syndrome Alliance to advance compassionate access to SKINJECT™, the Company’s investigational doxorubicin containing microneedle arrays for patients suffering from Gorlin Syndrome, also known as nevoid basal cell carcinoma syndrome.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
