MrgprC11+ Sensory Neurons Mediate Glabrous Skin Itch

Investigators developed a mouse glabrous skin behavioral assay to investigate the contribution of three previously identified pruriceptive neurons in glabrous skin itch.
[Proceedings of the National Academy of Sciences of the United States of America]
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Activation of Matrix Metalloproteinases and FoxO3a in HaCaT Keratinocytes by Radiofrequency Electromagnetic Field Exposure

The authors evaluated the use and trends of active comparator trial designs in dermatology.
[Scientific Reports]
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Female Immunity Protects from Cutaneous Squamous Cell Carcinoma

Researchers presented data showing women presented less aggressive primary cutaneous squamous cell carcinoma and early strong immune activation.
[Clinical Cancer Research]
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AbbVie Announces Extension of Review for Supplemental New Drug Application of Upadacitinib for the Treatment of Moderate to Severe Atopic Dermatitis

AbbVie announced that the US FDA has extended the review period for the supplemental New Drug Application for upadacitinib in the treatment of adults and adolescents with moderate to severe atopic dermatitis.
[AbbVie (PRNewswire)]
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Epigenetic Reprogramming of Tumor Cell–Intrinsic STING Function Sculpts Antigenicity and T Cell Recognition of Melanoma

Scientists showed that promoter hypermethylation of cGAS and stimulator of interferon genes (STING) mediated their coordinated transcriptional silencing and contributed to the widespread impairment of the STING signaling function in clinically-relevant human melanomas and melanoma cell lines.
[Proceedings of the National Academy of Sciences of the United States of America]
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Myeloid Cell–Derived HOCl Is a Paracrine Effector That Trans-inhibits IKK/NF-κB in Melanoma Cells and Limits Early Tumor Progression

Investigators revealed a role for myeloid-derived cells-derived hypochlorous acid (HOCl) as a small-molecule paracrine signaling factor that trans-inhibited inhibited IκB kinase (IKK) in melanoma tumor cells, mediating antitumor responses during early tumor progression.
[Science Signaling]
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CSDE1 Attenuates microRNA-Mediated Silencing of PMEPA1 in Melanoma

Scientists showed that PMEPA1 promoted tumorigenic traits and that CSDE1 along with miR-129-5p/AGO2 miRISC acted antagonistically to fine-tune PMEPA1 expression toward the progression of melanoma.
[Oncogene]
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Use of Active Comparator Trials for Topical Medications in Dermatology

Some new medications may improve patient outcomes, others may not offer meaningful benefits vs existing less costly alternatives, especially in dermatology, in which subtle changes in the concentration or combination of topical agents can be classified as a novel product.
[JAMA Dermatology]
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Pfizer Announces Extension of Review of New Drug Application of Abrocitinib for the Treatment of Moderate to Severe Atopic Dermatitis

Pfizer, Inc. announced that the US FDA has extended the priority review period for the New Drug Application for abrocitinib for the treatment of adults and adolescents with moderate to severe atopic dermatitis.
[Pfizer Inc. (businesswire)]
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Complement Factor I Upregulates Expression of Matrix Metalloproteinase‐13 and ‐2 and Promotes Invasion of Cutaneous Squamous Carcinoma Cells

The authors studied the functional role of complement factor I (CFI) in the progression of cutaneous squamous cell carcinoma (cSCC). CFI was knocked down in cSCC cells and RNA‐seq analysis was performed.
[Experimental Dermatology]
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Current Standards and Pitfalls Associated with the Transfection of Primary Fibroblast Cells

Scientists describe critical points that should be considered when selecting a method for transfecting fibroblasts.
[Biotechnology Progress]
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