Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

PFKFB4 Interacts With ICMT and Activates RAS/AKT Signaling-Dependent Cell Migration in Melanoma

[Life Science Alliance] Scientists reported that PFKFB4 promoted isoprenylcystein carboxymethyl transferase/RAS interaction, controlled RAS localization at the plasma membrane, activated AKT signaling and enhanced melanoma cell migration.

AP-1 Transcription Factor Network Explains Diverse Patterns of Cellular Plasticity in Melanoma Cells

[Cell Reports] Scientists reported that a regulated balance among AP-1 factors cJUN, JUND, FRA2, FRA1, and cFOS determines the intrinsic diversity of differentiation states and adaptive responses to MAPK inhibitors in melanoma cells.

Arcutis Completes Enrollment in INTEGUMENT-1 Pivotal Phase III Trial of Roflumilast Cream in Atopic Dermatitis

[Arcutis Biotherapeutics, Inc.] Arcutis Biotherapeutics, Inc. announced the enrollment of the last subject in its INTEGUMENT-1 pivotal Phase III trial of roflumilast cream 0.15% in adults and children with atopic dermatitis.

α-Enolase Inhibits Apoptosis and Promotes Cell Invasion and Proliferation of Skin Cutaneous Melanoma

[Molecular Biology Reports] Scientists reported that in skin cutaneous melanoma cells, α-Enolase overexpression promoted invasion, migration, and proliferation of tumor cells; increased pyruvate and lactate production; and increased β-catenin, MMP-9, MMP-13, and c-Myc levels.

Peptide Nanogels as a Scaffold for Fabricating Dermal Grafts and 3D Vascularized Skin Models

[Journal of Tissue Engineering] Investigators tested the efficacy of ultrashort tetrameric peptides for the fabrication of dermal grafts and 3D vascularized skin tissue models.

Knockout of Integrin β1 in Induced Pluripotent Stem Cells Accelerates Skin-Wound Healing by Promoting Cell Migration in Extracellular Matrix

[Stem Cell Research & Therapy] Investigators knocked out Itgb1 in mouse iPSCs and evaluated its effects on the therapeutic potential of topically applied iPSCs, as well as their underlying in vivo and in vitro mechanisms.

Growth Factor and Cytokine Delivery Systems for Wound Healing

[Cold Spring Harbor Perspectives in Biology] Short half-life, poor stability, rapid diffusion, uncontrolled signaling, and systemic side effects are currently the key challenges to developing efficient growth factor- and cytokine-based therapies.

Targeting the Hippo/YAP/TAZ Signaling Pathway: Novel Opportunities for Therapeutic Interventions into Skin Cancers

[Experimental Dermatology] The authors summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.

AURKA Is a Prognostic Potential Therapeutic Target in Skin Cutaneous Melanoma Modulating the Tumor Microenvironment, Apoptosis, and Hypoxia

[Journal of Cancer Research and Clinical Oncology] Scientists reported that the small-molecule compound ZNC97018978 targeting Aurora Kinase A (AURKA) screened by molecular docking technology can inhibit the proliferation, invasion and metastasis of skin cutaneous melanoma (SKCM).

SerpinB7 Deficiency Contributes to Development of Psoriasis via Calcium-Mediated Keratinocyte Differentiation Dysfunction

[Cell Death & Disease] Investigators reported that SerpinB7 deficiency resulted in excessive proliferation and impaired differentiation, as well as increased chemokines and antimicrobial peptide expression in normal human epidermal keratinocyte and mouse primary keratinocyte.

Calcium/Calmodulin-Dependent Protein Kinase IV Promotes Imiquimod-Induced Psoriatic Inflammation via Macrophages and Keratinocytes in Mice

[Nature Communications] Scientists reported that In keratinocytes, CaMK4 inhibited apoptosis as well as promoted cell proliferation and the expression of pro-inflammatory genes such as S100A8 and CAMP.

Tumor-Promoting Properties of Karyopherin β1 in Melanoma by Stabilizing Ras-GTPase-Activating Protein SH3 Domain-Binding Protein 1

[Cancer Gene Therapy] Researchers demonstrated that karyopherin β1 (KPNB1) knockdown significantly retarded the growth and metastasis of melanoma cells in vitro and in vivo, and increased their sensitivity towards the anti-tumor drug cisplatin.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.