Dermal Cell News

Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.

Glucocorticoid Signaling and Regulatory T Cells Cooperate to Maintain the Hair-Follicle Stem-Cell Niche

[Nature Immunology] By using hair follicles (HFs) to study regulatory T cell cell–stem cell crosstalk, the authors showed an unrecognized function of the steroid hormone glucocorticoid in instructing skin-resident Treg cells to facilitate HF stem-cell activation and HF regeneration.

Silver-Doped Phosphate Coacervates to Inhibit Pathogenic Bacteria Associated with Wound Infections: An In Vitro Study

[Scientific Reports] Researchers suggested that gel-like silver doped phosphate-based coacervates were promising multifunctional materials for smart wound dressings, being capable of simultaneously inhibiting pathogenic bacteria and maintaining good cell viability.

Human Organ Rejuvenation by VEGF-A: Lessons from the Skin

[Science Advances] While intradermally injected vascular endothelial growth factor (VEGF)-loaded nanoparticles sufficed to induce a molecular rejuvenation signature in aged human skin on old mice, VEGF-A treatment improved key aging parameters also in isolated, organ-cultured aged human skin, i.e., in the absence of functional skin vasculature, neural, or murine host inputs.

Synergistic Antitumor Effect of a Penicillin Derivative Combined with Thapsigargin in Melanoma Cells

[Journal of Cancer Research and Clinical Oncology] The synergistic antiproliferative effect of TAP7f in combination with thapsigargin was studied in vitro in murine B16-F0 melanoma cells, and in human A375 and SB2 melanoma cells.

Multi-Omic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines

[Molecular & Cellular Proteomics] FRET-based biosensor screening revealed that cannabidiol elicited a sharp rise in cytosolic calcium, and activation of AMPK in human keratinocyte and neuroblastoma cell lines.

Cobalt Protoporphyrin Promotes Human Keratinocyte Migration under Hyperglycemic Conditions

[Molecular Medicine] An in vitro wound healing model that mimicked re-epithelialization was established to examine the effect of cobalt protoporphyrin on the migratory capability of human keratinocytes in either normal glucose or high glucose media, as well as in the presence of either H2O2 or lipopolysaccharide.

Machine-Learning-Optimized Cas12a Barcoding Enables the Recovery of Single-Cell Lineages and Transcriptional Profiles

[Molecular Cell] Scientists coupled dual acting inverted site array barcoding with single-cell RNA-seq to recover lineages and gene expression profiles from ∼47,000 human melanoma cells.

Inhibitory Activity of Soybean (Glycine max L. Merr.) Cell Culture Extract on Tyrosinase Activity and Melanin Formation in Alpha-Melanocyte Stimulating Hormone-Induced B16-F10 Melanoma Cells

[Molecular Biology Reports] Researchers found that the effects of soybean cell culture extract on alpha-melanocyte-stimulating hormone induced melanogenesis in B16-F10 murine melanoma cells.

Lipopolysaccharide Reduces Melanin Synthesis in Vitiligo Melanocytes by Regulating Autophagy

[Experimental Dermatology] Lipopolysaccharide suppressed melanin synthesis, downregulated the expression of melanin synthesis-related proteins, and activated autophagy in vitiligo melanocytes.

Targeting Inflamed and Non-Inflamed Melanomas: Biological Background and Clinical Challenges

[Seminars in Cancer Biology] Scientists focus on the morphologic and immunohistochemical characteristics of the tumor microenvironment, and on the molecular determinants of resistance to immunotherapy, differentiating between inflamed and non-inflamed melanomas.

Research Progress of Natural Tissue-Derived Hydrogels for Tissue Repair and Reconstruction

[International Journal of Biological Macromolecules] The authors review the latest research advances in the field of hydrogels from a variety of natural tissue sources, including bone tissue, blood vessels, nerve tissue, adipose tissue, skin tissue, and muscle tissue, including preparation methods, advantages, and applications in tissue engineering, and regenerative medicine.

Krystal Biotech Submits Biologics License Application to U.S. FDA Seeking Approval of B-VEC for the Treatment of Patients with Dystrophic Epidermolysis Bullosa

[Krystal Biotech, Inc.] Krystal Biotech, Inc. announced the submission of a Biologics License Application FDA seeking approval of B-VEC for the treatment of patients with dystrophic epidermolysis bullosa.

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.