Category Archives: Dermal Cell

Dermal Cell News is an online publication and email newsletter highlighting the latest research about wound healing, skin disorders, and dermal cancers.
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As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.

Amyloid Aggregates Accumulate in Melanoma Metastasis Modulating YAP Activity

Using secretome analyses, the authors revealed the extracellular accumulation of amyloidogenic proteins, i.e. premelanosome protein, in metastatic melanoma, together with proteins that assist amyloid maturation into fibrils.
[EMBO Reports]
Matafora, V., Farris, F., Restuccia, U., Tamburri, S., Martano, G., Bernardelli, C., Sofia, A., Pisati, F., Casagrande, F., Lazzari, L., Marsoni, S., Bonoldi, E., & Bachi, A. (2020). Amyloid aggregates accumulate in melanoma metastasis modulating YAP activity. EMBO Reports, n/a(n/a), e50446. https://doi.org/10.15252/embr.202050446 Cite
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Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
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Emerging Role of FBXO22 in Carcinogenesis

Scientists summarize the regulatory factors and downstream targets of F-box protein 22 (FBXO22) in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
Cheng, J., Lin, M., Chu, M., Gong, L., Bi, Y., & Zhao, Y. (2020). Emerging role of FBXO22 in carcinogenesis. Cell Death Discovery, 6(1), 1–7. https://doi.org/10.1038/s41420-020-00303-0 Cite
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Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model

Researchers used CRISPR-Cas9 gene targeting to generate a library of 3D organotypic skin tissues that selectively differed in their capacity to produce glycan structures on the main types of N- and O-linked glycoproteins and glycolipids. This tissue library revealed distinct changes in skin formation associated with a loss of features for all tested glycoconjugates.
[Developmental Cell]
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Small Extracellular Vesicles Containing miR-381-3p from Keratinocytes Promotes Th1/Th17 Polarization in Psoriasis

Investigators proposed that psoriatic keratinocytes transferred miR-381-3p to CD4 + T cells via small extracellular vesicles, inducing Th1/Th17 polarization and promoting psoriasis development.
[Journal of investigative Dermatology]
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Co-Loading of Finasteride and Baicalin in Phospholipid Vesicles Tailored for the Treatment of Hair Disorders

Finasteride was loaded in phospholipid vesicles and baicalin was co-loaded as an adjuvant. Their effect on hair growth was evaluated in vitro and in vivo.
[Nanoscale]
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Plasma Treatment Limits Cutaneous Squamous Cell Carcinoma Development In Vitro and In Vivo

Using the kINPen argon plasma jet, a selective growth-reducing action of plasma treatment was identified in two squamous cell carcinoma cell lines in 2D and 3D cultures.
[Cancers]
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Signaling of Tumor-Derived sEV Impacts Melanoma Progression

The authors feature melanoma cell-derived exosomes with special emphasis on exosome-mediated signaling between melanoma cells and the host immune system.
[International Journal of Molecular Sciences]
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Checkmate Pharmaceuticals Granted FDA Fast Track Designation for CMP-001 Combined with PD-1 Blockade in the Treatment of Certain Types of Metastatic or Unresectable Melanoma

Checkmate Pharmaceuticals, Inc. announced that the FDA granted Fast Track designation to its product candidate, CMP-001, in combination with a programmed death receptor 1 (PD-1) blocking antibody for initial treatment of patients with unresectable stage III or stage IV melanoma; and treatment of patients with unresectable or metastatic melanoma refractory to prior anti-PD-1 blockade.
[Checkmate Pharmaceuticals (BusinessWire, Inc.)]
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The CDK4/6-EZH2 Pathway Is a Potential Therapeutic Target for Psoriasis

Delineation of the pathway revealed that CDK4/6 phosphorylated EZH2 in keratinocytes, thereby triggering a methylation-induced activation of STAT3.
[Journal of Clinical Investigation]
Müller, A., Dickmanns, A., Resch, C., Schäkel, K., Hailfinger, S., Dobbelstein, M., Schulze-Osthoff, K., & Kramer, D. (2020). The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI134217 Cite
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French Science Bill Promises Boost to Public R&D

The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider]
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