Category Archives: Dermal Cell

Dermal Cell News is an online publication and email newsletter highlighting the latest research about wound healing, skin disorders, and dermal cancers.
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As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.

The Anti-Skin Squamous Cell Carcinoma Cell Activity by the SphK1-Targeting microRNA-6784

The authors identified a novel SphK1-targeting microRNA, microRNA-6784 (miR-6784). They showed that miR-6784 was located at the cytoplasm of A431 skin squamous cell carcinoma cells.
[Aging]
Aging | The anti-skin squamous cell carcinoma cell activity by the SphK1-targeting microRNA-6784 - Full Text. (n.d.). Retrieved January 22, 2021, from https://www.aging-us.com/article/202336/text Cite
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Differences of Embedding Adipose-Derived Stromal Cells in Natural and Synthetic Scaffolds for Dermal and Subcutaneous Delivery

Scientists investigate the trends in injectable scaffolds for adipose-derived stromal cell (ASC) delivery in the dermis, and injectable or implantable scaffolds for ASC delivery in the subcutis.
[Stem Cell Research & Therapy]
Differences of embedding adipose-derived stromal cells in natural and synthetic scaffolds for dermal and subcutaneous delivery | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved January 23, 2021, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-02132-5 Cite
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Activation of the Tumor Suppressive Hippo Pathway by Triptonide as a New Strategy to Potently Inhibit Aggressive Melanoma Cell Metastasis

Researchers showed that the small molecule triptonide robustly suppressed melanoma cell tumorigenicity, migration, and invasion.
[Biochemical Pharmacology]
Tan, S., Zhao, Z., Qiao, Y., Zhang, B., Zhang, T., Zhang, M., Qi, J., Wang, X., Meng, M., & Zhou, Q. (2021). Activation of the tumor suppressive Hippo pathway by triptonide as a new strategy to potently inhibit aggressive melanoma cell metastasis. Biochemical Pharmacology, 114423. https://doi.org/10.1016/j.bcp.2021.114423 Cite
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Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase

Human keratinocytes cells were used as an experimental model for studies on the effects of platelet-rich plasma on cell proliferation, migration, collagen biosynthesis, prolidase activity, and its expression and anabolic signaling.
[International Journal of Molecular Sciences]
Misiura, M., Guszczyn, T., Oscilowska, I., Baszanowska, W., Palka, J., & Miltyk, W. (2021). Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase. International Journal of Molecular Sciences, 22(2), 936. https://doi.org/10.3390/ijms22020936 Cite
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NECTIN4: A Novel Therapeutic Target for Melanoma

The authors investigated the role of nectin cell adhesion molecule 4 (NECTIN4) in melanoma and its potency as a therapeutic target using 126 melanoma samples and BRAFi-resistant cells.
[International Journal of Molecular Sciences]
Tanaka, Y., Murata, M., Shen, C.-H., Furue, M., & Ito, T. (2021). NECTIN4: A Novel Therapeutic Target for Melanoma. International Journal of Molecular Sciences, 22(2), 976. https://doi.org/10.3390/ijms22020976 Cite
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CSN6 Promotes Melanoma Proliferation and Metastasis by Controlling the UBR5-Mediated Ubiquitination and Degradation of CDK9

In melanoma cells, constitutive photomorphogenesis 9 signalosome 6 (CSN6) knockdown remarkably inhibited cell proliferation, tumorigenicity, migration, and invasion, whereas CSN6 recovery rescued the proliferative and metastatic abilities.
[Cell Death & Disease]
Zhang, Y., Hou, J., Shi, S., Du, J., Liu, Y., Huang, P., Li, Q., Liu, L., Hu, H., Ji, Y., Guo, L., Shi, Y., Liu, Y., & Cui, H. (2021). CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9. Cell Death & Disease, 12(1), 1–12. https://doi.org/10.1038/s41419-021-03398-0 Cite
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Pannexin 3 Regulates Skin Development via Epiprofin

The authors demonstrated that Pannexin 3 (Panx3) regulated skin development by modulating the transcription factor, Epiprofin (Epfn). In cell culture, Panx3 overexpression promoted HaCaT cell differentiation, cell cycle exit and enhanced Epfn expression.
[Scientific Reports]
Zhang, P., Ishikawa, M., Doyle, A., Nakamura, T., He, B., & Yamada, Y. (2021). Pannexin 3 regulates skin development via Epiprofin. Scientific Reports, 11(1), 1779. https://doi.org/10.1038/s41598-021-81074-1 Cite
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Epidermal Progenitors Suppress GRHL3-Mediated Differentiation through Intronic Polyadenylation Promoted by CPSF-HNRNPA3 Collaboration

Scientists showed that hundreds of intronic polyadenylation sites were differentially used during keratinocyte differentiation, which was accompanied by downregulation of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex.
[Nature Communications]
Chen, X., Lloyd, S. M., Kweon, J., Gamalong, G. M., & Bao, X. (2021). Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration. Nature Communications, 12(1), 448. https://doi.org/10.1038/s41467-020-20674-3 Cite
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Hair Follicle Germs Containing Vascular Endothelial Cells for Hair Regenerative Medicine

Epithelial, dermal papilla, and vascular endothelial cells initially formed a single aggregate, which subsequently became a dumbbell-shaped HFG, wherein the vascular endothelial cells localized in the region of dermal papilla cells.
[Scientific Reports]
Hair follicle germs containing vascular endothelial cells for hair regenerative medicine | Scientific Reports. (n.d.). Retrieved January 18, 2021, from https://www.nature.com/articles/s41598-020-79722-z Cite
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Exosomes from Adipose-Derived Stem Cells and Application to Skin Wound Healing

Scientists describes the mechanisms whereby adipose‐derived stem cells‐exosomes regulate wound healing and their clinical application.
[Cell Proliferation]
An, Y., Lin, S., Tan, X., Zhu, S., Nie, F., Zhen, Y., Gu, L., Zhang, C., Wang, B., Wei, W., Li, D., & Wu, J. (n.d.). Exosomes from adipose-derived stem cells and application to skin wound healing. Cell Proliferation, n/a(n/a), e12993. https://doi.org/https://doi.org/10.1111/cpr.12993 Cite
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Interfollicular Epidermal Stem-Like Cells for the Recreation of the Hair Follicle Epithelial Compartment

Scientists investigated whether human interfollicular epidermal keratinocytes with stem-like features, characterized by a α6bri/CD71dim expression, could replace human hair follicular keratinocytes for the recreation of the hair follicle epithelium and respective epithelial-mesenchymal interactions.
[Stem Cell Research & Therapy]
Abreu, C. M., Pirraco, R. P., Reis, R. L., Cerqueira, M. T., & Marques, A. P. (2021). Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment. Stem Cell Research & Therapy, 12(1), 62. https://doi.org/10.1186/s13287-020-02104-9 Cite
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