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Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Single-Cell Transcriptomics Reveals Aberrant Skin-Resident Cell Populations and Identifies Fibroblasts as a Determinant in Rosacea
[Nature Communications] Scientists generated a single-cell atlas of facial skin from female rosacea patients and healthy individuals. Among keratinocytes, a subpopulation characterized by IFNγ-mediated barrier function damage was found to be unique to rosacea lesions.
The lncRNA SNHG26 Drives the Inflammatory-to-Proliferative State Transition of Keratinocyte Progenitor Cells During Wound Healing
[Nature Communications] Single-cell transcriptome analysis combined with gain-of-function and loss-of-function of SNHG26 in vitro and ex vivo revealed its specific role in facilitating inflammatory-to-proliferative state transition of keratinocyte progenitors.
Mapping Epidermal and Dermal Cellular Senescence in Human Skin Aging
[Aging Cell] In the epidermis, senescent melanocytes were associated with elevated melanin synthesis, suggesting haphazard pigmentation, while in the dermis, senescent reticular dermal fibroblasts were associated with decreased collagen and elastic fiber synthesis.
4-Aminopyridine Attenuates Inflammation and Apoptosis and Increases Angiogenesis to Promote Skin Regeneration Following a Burn Injury in Mice
[Cell Death Discovery] Investigators repurposed 4-aminopyridine (4-AP), a drug approved by the US FDA for multiple sclerosis, to treat severe burns in mice, reporting that that 4-AP reduced early inflammation via orai calcium release-activated calcium modulator 1-pSTAT6 signaling and reduced apoptosis.
Induction of Immunogenic Cell Death and Enhancement of the Radiation-Induced Immunogenicity by Chrysin in Melanoma Cancer Cells
[Scientific Reports] The authors examined the effects of chrysin alone and in combination with radiation on immunogenic cell death (ICD) induction in melanoma, finding that chrysin could induce ICD and intensify the radiotherapy-induced immunogenicity.
Toripalimab in Combination with HBM4003, an Anti-CTLA-4 Heavy Chain-Only Antibody, in Advanced Melanoma and Other Solid Tumors: An Open-Label Phase I Trial
[Journal For Immunotherapy of Cancer] This Phase I trial investigated the safety, pharmacokinetics, immunogenicity, and preliminary efficacy of HBM4003 plus with anti-PD-1 antibody toripalimab in patients with advanced solid tumors, especially focusing on melanoma.
Recent Advances in Bacterium-Based Therapeutic Modalities for Melanoma Treatment
[Advanced Healthcare Materials] The authors provide a summary of the state-of-the-art bacterium-based anti-melanoma modalities, which are categorized according to their unique functional merits, including tumor-specific cytotoxins, tumor-targeted drug delivery platforms, and immune-stimulatory agents.
Circular RNA-Encoded Oncogenic PIAS1 Variant Blocks Immunogenic Ferroptosis by Modulating the Balance Between SUMOylation and Phosphorylation of STAT1
[Molecular Cancer] The impact of circPIAS1-108aa on the ferroptosis process of melanoma cells was studied through glutathione, malondialdehyde, and C11-BODIPY staining assays. Proliferation changes in melanoma cells were assessed using cell counting Kit-8, EdU, and colony formation assays.
IRF2 Loss Is Associated with Reduced MHC I Pathway Transcripts in Subsets of Most Human Cancers and Causes Resistance to Checkpoint Immunotherapy in Human...
[Journal of Experimental & Clinical Cancer Research] CRISRPcas9 was used to knock out IRF1 and IRF2 genes in human and mouse melanoma cells and the resulting phenotypes were analyzed in vitro and in vivo.
Gal-3 Blocks the Binding between PD-1 and Pembrolizumab
[Journal For Immunotherapy of Cancer] Researchers investigated the binding between PD-1, pembrolizumab, and galectin-3 (Gal-3) by surface plasmon resonance and cryogenic electron microscopy. The function was studied in in vitro cultures and soluble levels of both PD-1 and Gal-3 were measured in metastatic melanoma patients, treated with pembrolizumab.
ACSL4-Mediated Lipid Rafts Prevent Membrane Rupture and Inhibit Immunogenic Cell Death in Melanoma
[Cell Death & Disease] Scientists discovered that lipid peroxidation promoted the formation of lipid rafts in the membrane, which mediated by acyl-coA synthetase long chain family member 4 (ACSL4) impaired the sensitivity of melanoma cells to platinum-based drugs.
Granular Porous Nanofibrous Microspheres Enhance Cellular Infiltration for Diabetic Wound Healing
[ACS Nano] Nanofibrous microspheres (NMs) demonstrated enhanced cell adhesion to human dermal fibroblasts during an in vitro cytocompatibility assessment. Additionally, NMs promoted host cell infiltration, neovascularization, and re-epithelialization in a diabetic mouse wound model.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
