lncRNA SNHG11 Facilitates Prostate Cancer Progression through the Upregulation of IGF-1R Expression and by Sponging miR-184

Researchers investigated the functional role and molecular mechanisms of SNHG11 in prostate cancer (PCa) progression. It was revealed that the SNHG11 expression levels were significantly upregulated in PCa tissues, in comparison with those in adjacent normal tissues.
[International Journal of Molecular Sciences]
Xie, Q., Zhao, S., Kang, R., & Wang, X. (2021). lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184. International Journal of Molecular Medicine, 48(3), 1–11. https://doi.org/10.3892/ijmm.2021.5015 Cite
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Cardiff Researcher Awarded £230K to Transform Prostate Cancer Treatment

Researchers from Cardiff University have received a grant worth over £230,000 from leading men’s health charity Prostate Cancer UK. The funding will help them develop a deeper understanding of how prostate cancer affects the immune system, so it’s clearer which men could benefit from powerful new immunotherapy treatments.
[Wales 247]
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PIWI-Interacting RNA in Cancer: Molecular Mechanisms and Possible Clinical Implications (Review)

The authors highlight the latest research progress made in the biological functions and regulation of PIWI‑interacting RNA in mammals, their involvement in various cancer forms and their potential clinical applications.
[Oncology Reports]
Yuan, C., Qin, H., Ponnusamy, M., Chen, Y., & Lin, Z. (2021). PIWI‑interacting RNA in cancer: Molecular mechanisms and possible clinical implications (Review). Oncology Reports, 46(3), 1–16. https://doi.org/10.3892/or.2021.8160 Cite
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Androgen Receptor Antagonists Produced by Streptomyces Overcome Resistance to Enzalutamide

From the natural product screening, the novel compound arabilin was isolated from Streptomyces sp. MK756-CF1. Unlike STK765173, arabilin could overcome resistance to enzalutamide.
[Journal of Antibiotics]
Imoto, M., Fujimaki, T., Saito, S., & Tashiro, E. (2021). Androgen receptor antagonists produced by Streptomyces overcome resistance to enzalutamide. The Journal of Antibiotics, 1–11. https://doi.org/10.1038/s41429-021-00453-y Cite
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CRISPR Screening Identifies CDK12 as a Conservative Vulnerability of Prostate Cancer

The authors performed a kinome-scale CRISPR/Cas9 screen and identified cyclin-dependent kinase 12 (CDK12) as being conservatively required for PCa cell survival.
[Cell Death & Disease]
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Biodistribution and Internal Radiation Dosimetry of a Companion Diagnostic Radiopharmaceutical, [68Ga]PSMA-11, in Subcutaneous Prostate Cancer Xenograft Model Mice

Researchers characterized the biodistribution and pharmacokinetics of [68Ga]PSMA-11 in prostate-specific membrane antigen (PSMA)-positive and negative tumor-bearing mice and subsequently estimated its internal radiation dosimetry via voxel-level dosimetry using a dedicated Monte Carlo simulation to evaluate the absorbed dose in the tumor directly.
[Scientific Reports]
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RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer

Scientists interrogated the regulation of RE1-silencing transcription factor, a transcriptional repressor of neuronal genes, and elucidated molecular programs driving amphicrine prostate cancer and neuroendocrine prostate cancer biology.
[Cancer Research]
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PHLDA3 Exerts an Antitumor Function in Prostate Cancer by Down-Regulating Wnt/β-Catenin Pathway via Inhibition of Akt

The relevance of pleckstrin homology-like domain family A, member 3 (PHLDA3) in prostate cancer has not been explored. Scientists illustrated the possible roles and mechanisms of PHLDA3 in prostate cancer.
[Biochemical and Biophysical Research Communications]
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Human Prostate Epithelial Cells and Prostate-Derived Stem Cells Malignantly Transformed In Vitro with Sodium Arsenite Show Impaired Toll Like Receptor -3 (TLR3)-Associated Anti-Tumor Pathway

Since inorganic arsenic targets prostatic stem cells, researchers hypothesized that arsenic-transformed stem cells show an impaired TLR3-associated anti-tumor pathway and, therefore, are unresponsive to polyinosinic:polycytidylic acid activation.
[Toxicology Letters]
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DNA-PKc Inhibition Overcomes Taxane Resistance by Promoting Taxane-Induced DNA Damage in Prostate Cancer Cells

Scientists proposed that alterations in DNA damage response pathway contributed to taxane resistance, and identification of these alterations may provide a potential therapeutic target to resensitize docetaxel-refractory mCRPC to taxane-based therapy.
[Prostate]
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LOC100996425 Acts as a Promoter in Prostate Cancer by Mediating Hepatocyte Nuclear Factor 4A and the AMPK/mTOR Pathway

Investigators determined effects of LOC100996425 on human prostate cancer by targeting hepatocyte nuclear factor 4A via the AMPK/mTOR pathway.
[Journal of Cellular and Molecular Medicine]
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