Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Propanc Biopharma Receives Notice of Allowance for Proenzyme Compositions to Treat Cancer from the European Patent Office

[Business Wire] Propanc Biopharma, Inc. today announced that a Notice of Allowance has been received from the European Patent Office for claims involving compositions of proenzymes to treat cancer.

The Short Inverted Repeats-Induced circEXOC6B Inhibits Prostate Cancer Metastasis by Enhancing the Binding of RBMS1 and HuR

[Molecular Therapy] Investigators discovered that circEXOC6B enhanced the binding of Human RNA Binding Motif Single Strand Interacting Protein 1 (RBMS1) and Human antigen R (HuR) and further increased A-kinase anchoring protein 12 (AKAP12) expression to inhibit prostate cancer metastasis.

Synergistic Enhancement of Cell Death by Triple Combination Therapy of Docetaxel, Ultrasound and Microbubbles, and Radiotherapy on PC3 a Prostate Cancer Cell Line

[Heliyon] Scientists reported that the triple combination therapy synergistically enhanced clonogenic cell death compared to single and double combination therapy.

Two calix[4]pyrroles As Potential Therapeutics for Castration-Resistant Prostate Cancer

[Investigational New Drugs] The authors conducted pre-clinical in vitro and in vivo studies and reported that calixpyrrole derivatives can inhibit cell growth in both PC3 and DU145 prostatic cancer cell lines.

Reformation of the Chondroitin Sulfate Glycocalyx Enables Progression of AR-Independent Prostate Cancer

[Nature Communications] Investigators demonstrated that changes in chondroitin sulfate , a major glycosaminoglycan component of the tumor cell glycocalyx and extracellular matrix, was androgen receptor-regulated and promoted the adaptive progression of CRPC after androgen receptor pathway inhibition.

Stem Cells As Target for Prostate Cancer Therapy: Opportunities and Challenges

[Stem Cell Reviews and Reports] Scientists explore the relevance of evaluating the TLR3 and P53 status in prostate cancer patients before starting an immunotherapy based on the use of Polyinosinic:Polycytidylic acid +9cRA to determine whether they will be responsive to treatment.

DDX5 mRNA-Targeting Antisense Oligonucleotide as a New Promising Therapeutic in Combating Castration-Resistant Prostate Cancer

[Molecular Therapy] Through the identification and analysis of DEAD-box protein 5 (DDX5) protein interaction networks, the authors identified some specific functions of DDX5 in CRPC that could contribute actively to tumor progression and therapeutic resistance.

Osteoclasts Directly Influence Castration-Resistant Prostate Cancer Cells

[Clinical & Experimental Metastasis] Osteolytic (PC-3) and osteoblastic (LNCaP-19) castration-resistant prostate cancer (CRPC) cells were co-cultured with mature osteoclasts or their precursor cells to characterize direct effects of mature osteoclasts on CRPC cells.

De Novo Design of an Androgen Receptor DNA Binding Domain-Targeted Peptide PROTAC for Prostate Cancer Therapy

[Advanced Science] The authors designed a novel peptide-based proteolysis-targeting chimera drug to induce androgen receptor and androgen receptor splice variant-7 degradation in a DNA binding domain and MDM2-dependent manner.

Griffith Launches Two Cancer Research Centres with $4.6M ACRF Funding

[Griffith University] Griffith University has launched two cancer research centres backed by $4.6 million in funding from the Australian Cancer Research Foundation (ACRF) this month.

FOXA1 Inhibits Hypoxia Programs through Transcriptional Repression of HIF1A

[Oncogene] Researchers reported that FOXA1 down-regulation induced hypoxia transcriptional programs, and Forkhead Box A1 (FOXA1) level was negatively correlated with hypoxia markers in clinical prostate cancer (PCa) samples.

White Adipose Tissue-Derived Factors and Prostate Cancer Progression: Mechanisms and Targets for Interventions

[Cancer and Metastasis Reviews] The authors discuss the role adipose stromal cells, the progenitors to mature adipocytes and other cell types in white adipose tissue, play in driving prostate cancer aggressiveness.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.