The authors underline the failures and promises of immunotherapy in prostate cancer, summarizing the current state of art regarding cancer vaccines and immune checkpoint monoclonal antibodies, and discussing future research directions in this immunologically “cold” malignancy.
6445218 LLPWTHAK items 1 apa default asc 1
Insulin-like growth factor 2 messenger RNA binding protein 3 expression level was significantly increased in prostate cancer tissues and cell lines as compared with the paracancerous normal tissues and cells.
[Journal of Experimental & Clinical Cancer Research]
6445218 NH2CK88I items 1 apa default asc 1
Zhang, X., Wang, D., Liu, B., Jin, X., Wang, X., Pan, J., Tu, W., & Shao, Y. (2020). IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way. Journal of Experimental & Clinical Cancer Research, 39(1), 190. https://doi.org/10.1186/s13046-020-01657-0 Cite
Investigators uncovered a novel mechanism of PTEN downregulation triggered by LIMK2, which contributes significantly to castration-resistant prostate cancer pathogenesis.
Vaccinium myrtillus berry extract and a recombined standard mixture of its main native phenolic compounds were investigated for cell growth inhibition and pro‐apoptotic activity on hormone‐dependent and hormone‐independent prostate cancer cell lines.
6445218 F4RJZSI6 items 1 apa default asc 1
Bubba, M. D., Serio, C. D., Renai, L., Scordo, C. V. A., Checchini, L., Ungar, A., Tarantini, F., & Bartoletti, R. (n.d.). Vaccinium myrtillus L. extract and its native polyphenol-recombined mixture have anti-proliferative and pro-apoptotic effects on human prostate cancer cell lines. Phytotherapy Research, n/a(n/a). https://doi.org/10.1002/ptr.6879 Cite
Researchers utilized a murine prostate organoid system to explore the effects of ERG on tumorigenesis and determined the mechanism underlying prostate cancer dependence on ERG.
6445218 EQPNM6J2 items 1 apa default asc 1
Shah, N., Kesten, N., Font-Tello, A., Chang, M. E. K., Vadhi, R., Lim, K., Flory, M. R., Cejas, P., Mohammed, H., Long, H. W., & Brown, M. (2020). ERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2044 Cite
Researchers evaluated the gene expression levels of the twenty-five selenoproteins and six HUB nodes in androgen receptor-positive and androgen receptor-negative cell lines.
[International Journal of Molecular Sciences]
6445218 RUIBNHRB items 1 apa default asc 1
Researchers demonstrated that EGF Like Repeats and Discoidin I Like Domains Protein 3 (EDIL3) expression levels were increased in paclitaxel-resistant breast and prostate cancer cells, and in subsets of high-grade breast and prostate tumors.
[Cell Death Discovery]
6630899 4LE5E3PU items 1 apa default asc 1
Gasca, J., Flores, M. L., Jiménez-Guerrero, R., Sáez, M. E., Barragán, I., Ruíz-Borrego, M., Tortolero, M., Romero, F., Sáez, C., & Japón, M. A. (2020). EDIL3 promotes epithelial–mesenchymal transition and paclitaxel resistance through its interaction with integrin α V β 3 in cancer cells. Cell Death Discovery, 6(1), 1–14. https://doi.org/10.1038/s41420-020-00322-x Cite
Using a kinome‐wide lentiviral small‐hairpin RNA library screen, scientists identified phosphoinositide‐dependent kinase‐1 as a potential mediator of cell survival in prostate cancer cells.
[Journal of Cellular and Molecular Medicine]
6445218 RNW49SUM items 1 apa default asc 1
Nalairndran, G., Razack, A. H. A., Mai, C.-W., Chung, F. F.-L., Chan, K.-K., Hii, L.-W., Lim, W.-M., Chung, I., & Leong, C.-O. (n.d.). Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15876 Cite
To assess the effect of sequential treatment with vitamin C and quercetin on Nrf2-related oxidative stress in PC3 and DU145 cells, viability was measured by MTT assay.
[Nutrition and Cancer-An International Journal]
6445218 AC84HSN7 items 1 apa default asc 1
Abbasi, A., Mostafavi-Pour, Z., Amiri, A., Keshavarzi, F., Nejabat, N., Ramezani, F., Sardarian, A., & Zal, F. (2020). Chemoprevention of Prostate Cancer Cells by Vitamin C plus Quercetin: role of Nrf2 in Inducing Oxidative Stress. Nutrition and Cancer, 0(0), 1–11. https://doi.org/10.1080/01635581.2020.1819346 Cite
ESSA Pharma Inc. announced that the FDA granted Fast Track Designation to EPI-7386, its oral and highly-selective N-terminal domain inhibitor of the androgen receptor, for the treatment of adult male patients with metastatic castration-resistant prostate cancer resistant to standard-of-care treatment.
[ESSA Pharma Inc.]
Scientists evaluated the efficacy of zingerone at different doses on the prostate cancer cell line regarding apoptosis, upstream signing molecules such as Akt/mTOR, and migration metastasis.
[Journal of Biochemical and Molecular Toxicology]
6445218 NUBV2HRS items 1 apa default asc 1
Zingerone suppresses cell proliferation via inducing cellular apoptosis and inhibition of the PI3K/AKT/mTOR signaling pathway in human prostate cancer PC‐3 cells - Qian - - Journal of Biochemical and Molecular Toxicology - Wiley Online Library. (n.d.). Retrieved September 10, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22611 Cite