The analysis of nuclear morphology of PC3 cells treated with triterpene-enriched fraction increased the number of cells with large and regular nuclei suggesting senescence induction, which was supported by β-galactosidase overexpression.
[Biomedicine & Pharmacotherapy]
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Cytotoxic effects of a triterpene‐enriched fraction of Cecropia pachystachya on the human hormone-refractory prostate cancer PC3 cell line - ScienceDirect. (n.d.). Retrieved August 11, 2020, from https://www.sciencedirect.com/science/article/pii/S0753332220307447?via%3Dihub Cite
Scientists used proteomics approaches to investigate the secreted proteins of paired human androgen-repressed prostate cancer cell lines, representing the epithelial and mesenchymal phenotypes.
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Researchers identified capping proteins CAPZA1 and CAPZB2 as PIM1 substrates, and showed that phosphorylation of either of them led to increased adhesion and migration of human prostate cancer cells.
[Cell Communication and Signaling]
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Santio, N. M., Vainio, V., Hoikkala, T., Mung, K. L., Lång, M., Vahakoski, R., Zdrojewska, J., Coffey, E. T., Kremneva, E., Rainio, E.-M., & Koskinen, P. J. (2020). PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins. Cell Communication and Signaling, 18(1), 121. https://doi.org/10.1186/s12964-020-00618-6 Cite
Hepatocyte growth factor activator inhibitor-2 overexpression could suppress the induction effect of TMPRSS2 on pro-HGF activation and prostate cancer cell invasion.
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Ko, C.-J., Hsu, T.-W., Wu, S.-R., Lan, S.-W., Hsiao, T.-F., Lin, H.-Y., Lin, H.-H., Tu, H.-F., Lee, C.-F., Huang, C.-C., Chen, M.-J. M., Hsiao, P.-W., Huang, H.-P., & Lee, M.-S. (2020). Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01413-w Cite
Cancer Targeted Technology announced that the NIH awarded CTT $1.44M on the second year of a competitive Small Business Innovation Research Phase IIB grant.
[Cancer Targeted Technology (Business Wire, Inc.)]
Researchers review the current status of immunotherapy, including new discoveries and precision approaches to prostate cancer, and discuss future directions in the continuously evolving landscape of immunotherapy.
[International Journal of Molecular Sciences]
The addition of chelerythrine significantly inhibited the proliferation of androgen-independent prostate cancer DU145 and PC-3 cells at the concentration of 5 and 10 μM, but not on androgen-dependent prostate cancer LNCaP cells as well as normal prostate epithelial cell line PrEC cells.
[Molecular and Cellular Biochemistry]
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ORIC Pharmaceuticals, Inc. announced it has entered into an exclusive worldwide license agreement with Mirati Therapeutics, Inc. ORIC will have exclusive worldwide rights for the development activities and commercialization of a small molecule allosteric inhibitor program directed towards the polycomb repressive complex 2, a validated oncogenic target across several cancers with promising therapeutic potential in prostate cancer, among other indications.
[ORIC Pharmaceuticals, Inc.]
Scientists developed curcumin nanoparticles and evaluated their cytotoxicity in docetaxel (DTX)-resistant castration-resistant prostate cancer (CRPC) cells for the treatment of DTX-resistant CRPC.
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Researchers integrated a computational proteochemometric systems network pharmacology platform, DrugGenEx‐Net, with primary, continuous cultures of conditionally reprogrammed normal and prostate cancer (PCa) cells derived from treatment‐naive patients with primary PCa.
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Naeem, A., Dakshanamurthy, S., Walthieu, H., Parasido, E., Avantaggiati, M., Tricoli, L., Kumar, D., Lee, R. J., Feldman, A., Noon, M. S., Byers, S., Rodriguez, O., & Albanese, C. (n.d.). Predicting new drug indications for prostate cancer: The integration of an in silico proteochemometric network pharmacology platform with patient-derived primary prostate cells. The Prostate, n/a(n/a). https://doi.org/10.1002/pros.24050 Cite
Scientists determined the effects of grape antioxidants quercetin and/or resveratrol against prostate cancer in the transgenic adenocarcinoma of mouse prostate (TRAMP)-model in prevention and intervention settings.
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In vitro studies showed that low-dose bisphenol A promoted the proliferation of human prostate fibroblasts and epithelial cells, and significantly upregulated the expression of cyclooxygenase-2 (COX-2) and L-PGDS in the cells.
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