Category Archives: Prostate Cell

Prostate Cell News is an online publication and email newsletter summarizing the latest prostate cell research.
Subscribe
Published every week since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.

Androgen Signaling Uses a Writer and a Reader of ADP-Ribosylation to Regulate Protein Complex Assembly

Scientists showed that ADP-ribosylation regulated androgen receptor (AR) through a nuclear pathway mediated by poly(ADP-ribose) polymerase 7 (Parp7). They showed that Parp7 mono-ADP-ribosylated agonist-bound AR, and that ADP-ribosyl-cysteines within the N-terminal domain mediated recruitment of the E3 ligase Dtx3L/Parp9.
[Nature Communications]
Yang, C.-S., Jividen, K., Kamata, T., Dworak, N., Oostdyk, L., Remlein, B., Pourfarjam, Y., Kim, I.-K., Du, K.-P., Abbas, T., Sherman, N. E., Wotton, D., & Paschal, B. M. (2021). Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly. Nature Communications, 12(1), 2705. https://doi.org/10.1038/s41467-021-23055-6 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Low Amounts of Heavy Water Increase the Phase Separation Propensity of a Fragment of the Androgen Receptor Activation Domain

Researchers investigated how using D2O as co‐solvent in an aqueous buffer changes the phase equilibrium of a fragment of the activation domain of the androgen receptor, a transcription factor that plays a role in the development of the male phenotype and is a therapeutic target for castration resistant prostate cancer.
[Protein Science]
Bielskutė, S., Garcia‐Cabau, C., Frigolé‐Vivas, M., Szulc, E., Mol, E. D., Pesarrodona, M., García, J., & Salvatella, X. (n.d.). Low amounts of heavy water increase the phase separation propensity of a fragment of the androgen receptor activation domain. Protein Science, n/a(n/a). https://doi.org/https://doi.org/10.1002/pro.4110 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Proliferating Cell Nuclear Antigen Directly Interacts with Androgen Receptor and Enhances Androgen Receptor‑Mediated Signaling

Investigators suggested that androgen receptor (AR) was a proliferating cell nuclear antigen (PCNA) partner protein and interacted with PCNA via the PCNA‑interacting protein‑box.
[International Journal of Oncology]
Lu, S., & Dong, Z. (2021). Proliferating cell nuclear antigen directly interacts with androgen receptor and enhances androgen receptor‑mediated signaling. International Journal of Oncology, 59(1), 1–10. https://doi.org/10.3892/ijo.2021.5221 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Tumor- and Osteoclast-Derived NRP2 in Prostate Cancer Bone Metastases

Researchers reported that targeting neuropilin 2 (NRP2) in cancer cells could enhance taxane-based chemotherapy with a better therapeutic outcome in bone metastasis, implicating NRP2 as a promising therapeutic target.
[Bone Research]
Polavaram, N. S., Dutta, S., Islam, R., Bag, A. K., Roy, S., Poitz, D., Karnes, J., Hofbauer, L. C., Kohli, M., Costello, B. A., Jimenez, R., Batra, S. K., Teply, B. A., Muders, M. H., & Datta, K. (2021). Tumor- and osteoclast-derived NRP2 in prostate cancer bone metastases. Bone Research, 9(1), 1–16. https://doi.org/10.1038/s41413-021-00136-2 Cite
Full Article
Bookmark

No account yet? Register

0
Share

ZIF‐Based Nanoparticles Combine X‐Ray‐Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy

In vitro and in vivo results indicated that zeolitic imidazole framework nanoparticles under X‐ray irradiation canould effectively promote the apoptosis of hypoxic prostate cancer cells.
[Angewandte Chemie-International Edition]
Li, Y., Gong, T., Gao, H., Chen, Y., Li, H., Zhao, P., Jiang, Y., Wang, K., Wu, Y., Zheng, X., & Bu, W. (n.d.). ZIF-Based Nanoparticles Combine X-Ray-Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy. Angewandte Chemie International Edition, n/a(n/a). https://doi.org/https://doi.org/10.1002/anie.202103015 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Inverse Agonism at the Na/K‐ATPase Receptor Reverses EMT in Prostate Cancer Cells

The authors showed that the loss of cell surface expression of Na/K‐ATPase α1 induced epithelial–mesenchymal transition and promoted metastatic potential and tumor growth of prostate cancer by decreasing the expression of E‐cadherin and increasing c‐Myc expression via the activation of Src/FAK pathways.
[Prostate]
Banerjee, M., Li, Z., Gao, Y., Lai, F., Huang, M., Zhang, Z., Cai, L., Sanabria, J., Gao, T., Xie, Z., & Pierre, S. V. (n.d.). Inverse agonism at the Na/K-ATPase receptor reverses EMT in prostate cancer cells. The Prostate, n/a(n/a). https://doi.org/https://doi.org/10.1002/pros.24144 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Avenda Health Granted FDA Breakthrough Device Designation for Technology to Treat Prostate Cancer

Breakthrough Device Designation was awarded to Avenda Health for a male “lumpectomy” product in development designed to treat prostate cancer in-office while preserving quality of life.
[Avenda Health (Business Wire, Inc.)]
Press Release
Bookmark

No account yet? Register

0
Share

Targeting Epigenetic and Post-Transcriptional Gene Regulation by PSF Impairs Hormone Therapy-Refractory Cancer Growth

Investigators conducted an in vitro chemical array screen and identified multiple small molecules that interacted with PSF. Several molecules inhibited RNA binding by PSF and decreased prostate cancer cell viability.
[Cancer Research]
Abstract
Bookmark

No account yet? Register

0
Share

Functional Mapping of Androgen Receptor Enhancer Activity

To characterize the regulatory logic of androgen receptor (AR)-mediated transcription, researchers generated a locus-specific map of enhancer activity by functionally testing all common clinical AR binding sites with Self-Transcribing Active Regulatory Regions sequencing.
[Genome Biology]
Full Article
Bookmark

No account yet? Register

0
Share

The Role of the p90 Ribosomal S6 Kinase Family in Prostate Cancer Progression and Therapy Resistance

Scientists review the roles of the p90 ribosomal S6 kinases in proliferation and motility, cell cycle control and therapy resistance in prostate cancer, highlighting the possible interplay between RSKs and Androgen Receptor in mediating disease progression.
[Oncogene]
Full Article
Bookmark

No account yet? Register

0
Share

Cryopreservation of Human Cancers Conserves Tumor Heterogeneity for Single-Cell Multi-Omics Analysis

Using the Chromium 10X platform, scientists sequenced a total of ~ 120,000 cells from fresh and cryopreserved replicates across three primary breast cancers, two primary prostate cancers and a cutaneous melanoma.
[Genome Medicine]
Full Article
Bookmark

No account yet? Register

0
Share
Share