Is There a Role for Immunotherapy in Prostate Cancer?

The authors underline the failures and promises of immunotherapy in prostate cancer, summarizing the current state of art regarding cancer vaccines and immune checkpoint monoclonal antibodies, and discussing future research directions in this immunologically “cold” malignancy.
[Cells]
Rizzo, A., Mollica, V., Cimadamore, A., Santoni, M., Scarpelli, M., Giunchi, F., Cheng, L., Lopez-Beltran, A., Fiorentino, M., Montironi, R., & Massari, F. (2020). Is There a Role for Immunotherapy in Prostate Cancer? Cells, 9(9), 2051. https://doi.org/10.3390/cells9092051 Cite
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IMP3 Accelerates the Progression of Prostate Cancer through Inhibiting PTEN Expression in a SMURF1-Dependent Way

Insulin-like growth factor 2 messenger RNA binding protein 3 expression level was significantly increased in prostate cancer tissues and cell lines as compared with the paracancerous normal tissues and cells.
[Journal of Experimental & Clinical Cancer Research]
Zhang, X., Wang, D., Liu, B., Jin, X., Wang, X., Pan, J., Tu, W., & Shao, Y. (2020). IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way. Journal of Experimental & Clinical Cancer Research, 39(1), 190. https://doi.org/10.1186/s13046-020-01657-0 Cite
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Negative Cross Talk Between LIMK2 and PTEN Promotes Castration Resistant Prostate Cancer Pathogenesis in Cells and In Vivo

Investigators uncovered a novel mechanism of PTEN downregulation triggered by LIMK2, which contributes significantly to castration-resistant prostate cancer pathogenesis.
[Cancer Letters]
Nikhil, K., Kamra, M., Raza, A., & Shah, K. (2020). Negative cross talk between LIMK2 and PTEN promotes castration resistant prostate cancer pathogenesis in cells and in vivo. Cancer Letters. https://doi.org/10.1016/j.canlet.2020.09.010 Cite
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Vaccinium Myrtillus L. Extract and Its Native Polyphenol-Recombined Mixture Have Anti-Proliferative and Pro-Apoptotic Effects on Human Prostate Cancer Cell Lines

Vaccinium myrtillus berry extract and a recombined standard mixture of its main native phenolic compounds were investigated for cell growth inhibition and pro‐apoptotic activity on hormone‐dependent and hormone‐independent prostate cancer cell lines.
[Phytotherapy Research]
Bubba, M. D., Serio, C. D., Renai, L., Scordo, C. V. A., Checchini, L., Ungar, A., Tarantini, F., & Bartoletti, R. (n.d.). Vaccinium myrtillus L. extract and its native polyphenol-recombined mixture have anti-proliferative and pro-apoptotic effects on human prostate cancer cell lines. Phytotherapy Research, n/a(n/a). https://doi.org/10.1002/ptr.6879 Cite
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ERG-Mediated Coregulator Complex Formation Maintains Androgen Receptor Signaling in Prostate Cancer

Researchers utilized a murine prostate organoid system to explore the effects of ERG on tumorigenesis and determined the mechanism underlying prostate cancer dependence on ERG.
[Cancer Research]
Shah, N., Kesten, N., Font-Tello, A., Chang, M. E. K., Vadhi, R., Lim, K., Flory, M. R., Cejas, P., Mohammed, H., Long, H. W., & Brown, M. (2020). ERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2044 Cite
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Integrated Analysis to Study the Relationship between Tumor-Associated Selenoproteins: Focus on Prostate Cancer

Researchers evaluated the gene expression levels of the twenty-five selenoproteins and six HUB nodes in androgen receptor-positive and androgen receptor-negative cell lines.
[International Journal of Molecular Sciences]
Capone, F., Polo, A., Sorice, A., Budillon, A., & Costantini, S. (2020). Integrated Analysis to Study the Relationship between Tumor-Associated Selenoproteins: Focus on Prostate Cancer. International Journal of Molecular Sciences, 21(18), 6694. https://doi.org/10.3390/ijms21186694 Cite
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EDIL3 Promotes Epithelial–Mesenchymal Transition and Paclitaxel Resistance through Its Interaction with Integrin αVβ3 in Cancer Cells

Researchers demonstrated that EGF Like Repeats and Discoidin I Like Domains Protein 3 (EDIL3) expression levels were increased in paclitaxel-resistant breast and prostate cancer cells, and in subsets of high-grade breast and prostate tumors.
[Cell Death Discovery]
Gasca, J., Flores, M. L., Jiménez-Guerrero, R., Sáez, M. E., Barragán, I., Ruíz-Borrego, M., Tortolero, M., Romero, F., Sáez, C., & Japón, M. A. (2020). EDIL3 promotes epithelial–mesenchymal transition and paclitaxel resistance through its interaction with integrin α V β 3 in cancer cells. Cell Death Discovery, 6(1), 1–14. https://doi.org/10.1038/s41420-020-00322-x Cite
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Phosphoinositide-Dependent Kinase-1 (PDPK1) Regulates Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) for Prostate Cancer Cell Survival

Using a kinome‐wide lentiviral small‐hairpin RNA library screen, scientists identified phosphoinositide‐dependent kinase‐1 as a potential mediator of cell survival in prostate cancer cells.
[Journal of Cellular and Molecular Medicine]
Nalairndran, G., Razack, A. H. A., Mai, C.-W., Chung, F. F.-L., Chan, K.-K., Hii, L.-W., Lim, W.-M., Chung, I., & Leong, C.-O. (n.d.). Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15876 Cite
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Chemoprevention of Prostate Cancer Cells by Vitamin C plus Quercetin: Role of Nrf2 in Inducing Oxidative Stress

To assess the effect of sequential treatment with vitamin C and quercetin on Nrf2-related oxidative stress in PC3 and DU145 cells, viability was measured by MTT assay.
[Nutrition and Cancer-An International Journal]
Abbasi, A., Mostafavi-Pour, Z., Amiri, A., Keshavarzi, F., Nejabat, N., Ramezani, F., Sardarian, A., & Zal, F. (2020). Chemoprevention of Prostate Cancer Cells by Vitamin C plus Quercetin: role of Nrf2 in Inducing Oxidative Stress. Nutrition and Cancer, 0(0), 1–11. https://doi.org/10.1080/01635581.2020.1819346 Cite
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ESSA Pharma Announces Fast Track Designation Granted by the FDA to EPI-7386 for the Treatment of Metastatic Castration-Resistant Prostate Cancer

ESSA Pharma Inc. announced that the FDA granted Fast Track Designation to EPI-7386, its oral and highly-selective N-terminal domain inhibitor of the androgen receptor, for the treatment of adult male patients with metastatic castration-resistant prostate cancer resistant to standard-of-care treatment.
[ESSA Pharma Inc.]
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Zingerone Suppresses Cell Proliferation via Inducing Cellular Apoptosis and Inhibition of the PI3K/AKT/mTOR Signaling Pathway in Human Prostate Cancer PC-3 Cells

Scientists evaluated the efficacy of zingerone at different doses on the prostate cancer cell line regarding apoptosis, upstream signing molecules such as Akt/mTOR, and migration metastasis.
[Journal of Biochemical and Molecular Toxicology]
Zingerone suppresses cell proliferation via inducing cellular apoptosis and inhibition of the PI3K/AKT/mTOR signaling pathway in human prostate cancer PC‐3 cells - Qian - - Journal of Biochemical and Molecular Toxicology - Wiley Online Library. (n.d.). Retrieved September 10, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22611 Cite
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