Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes

[Cancer Discovery] Scientists sequenced plasma circulating tumor DNA whole genomes from patient-derived xenografts representing a spectrum of androgen receptor active and neuroendocrine prostate cancers.

Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling

[Cancer Research] The authors reported that inhibitors of the mitotic regulator polo-like kinase-1 (Plk1), including the Plk1 inhibitor onvansertib, synergized with abiraterone in vitro and in vivo to kill a subset of cancer cells from a wide variety of tumor types in an androgen-independent manner.

Macromolecular NO-Donor Micelles for Targeted and Augmented Chemotherapy against Prostate Cancer

[Advanced Healthcare Materials] A bombesin installed nanoplatform combining the chemotherapeutic mitoxantrone (MTO) and the chemotherapeutic sensitizer of nitric oxide (NO) was developed based on MTO-loaded macromolecular NO-donor-containing polymeric micelles for targeted NO-sensitized chemotherapy against prostate cancer.

has_circ_0070512 Promotes Prostate Cancer Progression by Regulating the miR-338-3p/Hedgehog Signaling Pathway

[Cancer Science] Researchers investigated the effect of hsa_circ_0070512 on the function and mechanism of prostate cancer (PCa). hsa_circ_0070512 was increased in PCa tissues and cells, and was mostly found in the cytoplasm of PCa cells.

Genetic Profiling of Hormone-Sensitive and Castration-Resistant Prostate Cancers and Identification of Genetic Mutations Prone to Castration-Resistant Prostate Cancer

[Prostate Cancer and Prostatic Diseases] A total of 103 samples were collected, including 62 DNA samples from the tumor tissues of 59 hormone-sensitive prostate cancer patients and 41 cell-free DNA samples from prostate cancer patients at different cancer stages.

Acetyl-CoA Carboxylase 1 Depletion Suppresses De Novo Fatty Acid Synthesis and Mitochondrial β-Oxidation in Castration-Resistant Prostate Cancer Cells

[Journal of Biological Chemistry] By mining public datasets, investigators discovered that the expression of acetyl-CoA carboxylase alpha, which encoded acetyl-CoA carboxylase 1, was highly expressed in human prostate cancer.

Biphasic Transcriptional and Post-Transcriptional Regulation of MYB by Androgen Signaling Mediates Its Growth Control in Prostate Cancer

[Journal of Biological Chemistry] The authors examined the effect of androgen signaling on MYB expression. Paralleling a dichotomous effect on growth, low-dose androgen induced MYB expression at both transcript and protein levels whereas it was suppressed in high-dose androgen-treated cells.

Resveratrol Suppresses Serum-Induced Vasculogenic Mimicry through Impairing the EphA2/Twist-VE-Cadherin/AKT Pathway in Human Prostate Cancer PC-3 Cells

[Scientific Reports] Scientists explored the new role of resveratrol in vasculogenic mimicry (VM) incidence in human prostate cancer PC-3 cells. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction, transwell invasion, and 3D culture VM tube formation assays were performed to check the cell viability, invasive ability, and vessel-like networks formation, respectively.

Blockage of MDM2-Mediated p53 Ubiquitination by Yuanhuacine Restrains the Carcinogenesis of Prostate Carcinoma Cells by Suppressing LncRNA LINC00665

[Journal of Biochemical and Molecular Toxicology] Researchers showed that yuanhuacine dose-dependently inhibited the proliferation and induced apoptosis of prostate cancer (PCa) cells. Yuanhuacine also restrained the invasion and migration of PCa cells.

Relationships between Holmium Laser Enucleation of the Prostate and Prostate Cancer

[Nature Reviews Urology] Prostate cancer is often found in men undergoing holmium laser enucleation of the prostate, and can be challenging to manage. Further work is still needed in variables associated with the detection of incidental prostate cancer, strategies to reduce incidental prostate cancer, and the natural history and management of this condition.

IND Approval from the US FDA for Theranostic SAR-Bombesin Trial in Prostate Cancer

[Clarity Pharmaceuticals] Clarity Pharmaceuticals announced the approval of its Investigational New Drug (IND) application by the US FDA to evaluate its SAR-Bombesin product for identification and treatment of metastatic castrate-resistant prostate cancer.

Lynparza in Combination with Abiraterone Recommended for Approval in the EU by CHMP as 1st-Line Treatment for Patients with Metastatic Castration-Resistant Prostate Cancer

[AstraZeneca] AstraZeneca and MSD’s Lynparza (olaparib) in combination with abiraterone and prednisone or prednisolone has been recommended for marketing authorization in the European Union (EU) for the treatment of adult patients with mCRPC for whom chemotherapy is not clinically indicated.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.