CRISPR Screening Identifies CDK12 as a Conservative Vulnerability of Prostate Cancer

The authors performed a kinome-scale CRISPR/Cas9 screen and identified cyclin-dependent kinase 12 (CDK12) as being conservatively required for PCa cell survival.
[Cell Death & Disease]
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Biodistribution and Internal Radiation Dosimetry of a Companion Diagnostic Radiopharmaceutical, [68Ga]PSMA-11, in Subcutaneous Prostate Cancer Xenograft Model Mice

Researchers characterized the biodistribution and pharmacokinetics of [68Ga]PSMA-11 in prostate-specific membrane antigen (PSMA)-positive and negative tumor-bearing mice and subsequently estimated its internal radiation dosimetry via voxel-level dosimetry using a dedicated Monte Carlo simulation to evaluate the absorbed dose in the tumor directly.
[Scientific Reports]
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RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer

Scientists interrogated the regulation of RE1-silencing transcription factor, a transcriptional repressor of neuronal genes, and elucidated molecular programs driving amphicrine prostate cancer and neuroendocrine prostate cancer biology.
[Cancer Research]
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PHLDA3 Exerts an Antitumor Function in Prostate Cancer by Down-Regulating Wnt/β-Catenin Pathway via Inhibition of Akt

The relevance of pleckstrin homology-like domain family A, member 3 (PHLDA3) in prostate cancer has not been explored. Scientists illustrated the possible roles and mechanisms of PHLDA3 in prostate cancer.
[Biochemical and Biophysical Research Communications]
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Human Prostate Epithelial Cells and Prostate-Derived Stem Cells Malignantly Transformed In Vitro with Sodium Arsenite Show Impaired Toll Like Receptor -3 (TLR3)-Associated Anti-Tumor Pathway

Since inorganic arsenic targets prostatic stem cells, researchers hypothesized that arsenic-transformed stem cells show an impaired TLR3-associated anti-tumor pathway and, therefore, are unresponsive to polyinosinic:polycytidylic acid activation.
[Toxicology Letters]
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DNA-PKc Inhibition Overcomes Taxane Resistance by Promoting Taxane-Induced DNA Damage in Prostate Cancer Cells

Scientists proposed that alterations in DNA damage response pathway contributed to taxane resistance, and identification of these alterations may provide a potential therapeutic target to resensitize docetaxel-refractory mCRPC to taxane-based therapy.
[Prostate]
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LOC100996425 Acts as a Promoter in Prostate Cancer by Mediating Hepatocyte Nuclear Factor 4A and the AMPK/mTOR Pathway

Investigators determined effects of LOC100996425 on human prostate cancer by targeting hepatocyte nuclear factor 4A via the AMPK/mTOR pathway.
[Journal of Cellular and Molecular Medicine]
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Diagnostic Potential of Serum Extracellular Vesicles Expressing Prostate-Specific Membrane Antigen in Urologic Malignancies

Investigators developed a sandwich ELISA to detect prostate-specific membrane antigen on small extracellular vesicles (EVs) using T-cell immunoglobulin domain and mucin domain-containing protein 4 as a capture molecule for EVs and to evaluate its diagnostic potential in urologic malignancies.
[Scientific Reports]
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Reduced DAPK1 Expression Promotes Stem Cell-Like Characteristics of Prostate Cancer Cells by Activating ZEB1via Hippo/YAP Signaling Pathway

Scientists reported that reduced death-associated protein kinase 1 (DAPK1) expression promoted stem cell-like characteristics of prostate cancer cells through activating zinc finger E-box binding homeobox-1 (ZEB1) via Hippo/YAP signaling pathway.
[Stem Cells and Development]
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Gestalt Diagnostics and Deep Bio Announce Strategic Relationship to Deliver Image Analysis Algorithms within Gestalt’s Digital Pathology Platform

Gestalt Diagnostics and Deep Bio announced their strategic relationship on the development of an integrated workflow for pathologists to use Artificial Intelligence algorithms directly within Gestalt’s PathFlow® platform. Deep Bio’s algorithm analyzes whole slide images of H&E-stained prostate core needle biopsy tissue specimens to detect and classify prostate cancer.
[Gestalt Diagnostics (Business Wire, Inc.)]
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Autophagy-Related circRNA Evaluation Reveals hsa_circ_0001747 as a Potential Favorable Prognostic Factor for Biochemical Recurrence in Patients with Prostate Cancer

The hsa_circ_0001747 signature was selected for further experimental verification in vitro and in vivo, which showed that downregulated hsa_circ_0001747 might facilitate prostate cancer via augmenting autophagy.
[Cell Death & Disease]
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