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Prostate Cell News
Prostate Cell News is an online resource summarizing the latest prostate cell research.
Evolution of Myeloid-Mediated Immunotherapy Resistance in Prostate Cancer
[Nature] Researchers used single-cell profiling on patient biopsies across the disease continuum and found that a distinct population of tumour-associated macrophages with elevated levels of SPP1 transcripts became enriched with the progression of prostate cancer to metastatic CRPC.
SENP3 Mediates deSUMOylation of SIX1 to Promote Prostate Cancer Proliferation and Migration
[Cellular & Molecular Biology Letters] Scientists found that sentrin/SUMO-specific protease 3 (SENP3) was highly expressed in prostate cancer (PCa) cell lines and tissues from PCa patients. Overexpressed SENP3 was associated with metastatic malignancy in PCa.
Trillin Inhibits MAP3K11/NF-κB/COX-2 Signaling Pathways through Upregulation of miR-145-5p in Castration-Resistant Prostate Cancer
[iScience] Using DU145 and PC3 cell lines and a mouse xenograft model, scientists demonstrate that Trillin effectively inhibited CRPC cell viability, proliferation, migration, and invasion while promoting apoptosis and cell cycle arrest.
Integrative Analysis Identifies the Atypical Repressor E2F8 as a Targetable Transcriptional Activator Driving Lethal Prostate Cancer
[Oncogene] To target E2F8 in CRPC, scientists employed the CRISPR/CasRx system to knockdown E2F8 mRNA, resulting in effective and specific downregulation of E2F8 and its target oncogenes, as well as significant growth inhibition in androgen receptor-negative CRPC in both cultured cells and xenograft models.
Small-Molecule Disruption of Androgen Receptor–Dependent Chromatin Clusters
[Proceedings of The National Academy of Sciences of The United States of America] Scientists reported androgen receptor (AR) antagonists with efficacy in AR-overexpressing models. These molecules bound to the ligand-binding domain of the AR, promote AR localization to the nucleus, yet potently and selectively down-regulated AR-target genes.
The Potential of TRP Channels as New Prognostic and Therapeutic Targets Against Prostate Cancer Progression
[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors discuss the contribution of Transient Receptor Potential channels in hallmarks of prrostate cancer (PCa), and then discuss their applicability as new prognostic and therapeutic agents in the fight against metastatic PCa.
Cancer Targeted Technology Receives Fast Track $2.4M Grant to Develop an Innovative PSMA-Targeted Small Molecule Drug Conjugate for Prostate Cancer
[Cancer Targeted Technology] Cancer Targeted Technology announced that the National Cancer Institute awarded the Phase I portion of the fast track Phase I/II Small Business Innovation Research grant to develop a new drug to treat metastatic prostate cancer.
CRIPTO’s Multifaceted Role in Driving Aggressive Prostate Cancer Unveiled by In Vivo, Organoid, and Patient Data
[Oncogene] Scientists demonstrated that suppressing Cripto in vivo significantly decreased invasive cell behavior in aggressive tumors, highlighting a critical oncogenic function of CRIPTO in advanced prostate cancer.
Dissecting the Novel Molecular Interactions of Solute Carrier Family 4 Member 4 (SLC4A4) for Prostate Cancer (PCa) Progression
[Scientific Reports] Scientists investigated the role of SLC4A4 and the signaling mechanism underlying its role in modulating the prostate cancer progression.
PGC-1α Drives Small Cell Neuroendocrine Cancer Progression Toward an ASCL1-Expressing Subtype with Increased Mitochondrial Capacity
[Proceedings of The National Academy of Sciences of The United States of America] Analyses using a human prostate tissue-based small cell neuroendocrine transformation system showed that the achaete-scute homolog 1 (ASCL1) subtype heightened PGC-1α expression and oxidative phosphorylation activity.
A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity Against Prostate Cancer
[Cancer Immunology Research] Scientists reported that the prostate-specific membrane antigen (PSMA) Tri-specific Killer Engager specifically bound to PSMA-expressing cells and significantly enhanced expansion, degranulation, and cytokine production of NK cells derived from healthy donors or prostate cancer patients.
Osteoblast-Derived ECM1 Promotes Anti-Androgen Resistance in Bone Metastatic Prostate Cancer
[Advanced Science] Researchers demonstrated that under enzalutamide treatment, osteoblasts in the bone microenvironment secrete increased levels of extracellular matrix protein 1 (ECM1), which affected surrounding prostate cancer cells, promoting tumor cell proliferation and anti-androgen resistance.
Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.
