Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Hexapeptides from Mammalian Inhibitory Hormone Hunt Activate and Inactivate Nematode Reproduction

[PLoS One] Reproduction had been investigated in the nematode Steinernema siamkayai, using a fermentation system supplemented with different concentrations of exogenous hexapeptides. Peptide structure-activity relationships had also been studied using prostate cancer and other mammalian cells in vitro.

Extensive Germline-Somatic Interplay Contributes to Prostate Cancer Progression through HNF1B Co-Option of TMPRSS2-ERG

[Nature Communications] Scientists observed an enrichment of transcription factor genes including HNF1B within prostate caner (PCa) risk-associated regions. While focused on the 17q12/HNF1B locus, they found a strong expression quantitative trait locus for HNF1B and multiple potential causal variants involved in the regulation of HNF1B expression in PCa.

ARID1A Loss Induces Polymorphonuclear Myeloid-Derived Suppressor Cell Chemotaxis and Promotes Prostate Cancer Progression

[Nature Communications] Researchers showed that AT-rich interactive domain-containing proteins 1 A (ARID1A), a subunit of the SWI/SNF chromatin remodeling complex, functioned downstream of inflammation-induced IKKβ activation to shape the immunosuppressive tumor microenvironment.

Saikosaponin a Enhances Docetaxel Efficacy by Selectively Inducing Death of Dormant Prostate Cancer Cells through Excessive Autophagy

[Cancer Letters] Saikosaponin A (SSA) was posed as a novel quiescent cancer cell (QCC)-eradicating agent by aggravating autophagy in QCCs. In combination with the current therapy, SSA had potential to improve treatment effectiveness and to prevent cancer recurrence.

Germline Variants in DNA Damage Repair Genes and HOXB13 among Black Patients with Early-Onset Prostate Cancer

[JCO Precision Oncology] Whole-exome sequencing of germline DNA from a population-based cohort of Black men diagnosed with prostate cancer at age 62 years or younger was performed.

Tautomycin and Enzalutamide Combination Yields Synergistic Effects on Castration-Resistant Prostate Cancer

[Cell Death Discovery] The authors reported an approach for suppressing reactivated androgen receptor (AR) signaling in the castration-resistant prostate cancer (CRPC) stage. A combination of the tautomycin and enzalutamide synergistically inhibited cell proliferation and AR signaling in LNCaP and C4-2 cells, as well as in AR variant-positive 22RV1 cells.

LNCaP-AI Prostate Cancer Cell Line Establishment by Flutamide and Androgen-Free Environment to Promote Cell Adherent

[BMC Molecular and Cell Biology] The LNCaP-androgen dependent cell line was cultured and passaged 60 times over 16 months. The morphology of the LNCaP-androgen independent (AI) cell line was observed. Androgen receptor levels identification were detected in qRT-PCR and Western blot assay.

Metabolic Syndrome Is Associated with Aggressive Prostate Cancer Regardless of Race

[Cancer Causes & Control] Among men undergoing prostate biopsy at the Durham Veterans Affairs Hospital, medical record data abstraction of diagnosis or treatment for hypertension, dyslipidemia, hypertriglyceridemia, diabetes, hyperglycemia, and central obesity were done.

Acidic Exo-Polysaccharide Obtained from Bacillus sp. NRC5 Attenuates Testosterone-DMBA-Induced Prostate Cancer in Rats via Inhibition of 5 α-Reductase and Na+/K+ ATPase Activity Mechanisms

[Current Microbiology] The anti-prostate cancer of acidic exo-polysaccharide produced from marine Bacillus sp. NRC5 was determined using 7,12-dimethylbenz-(a)-anthracene (DMBA) and DMBA-induced prostate cancer in male Sprague Dawley rats.

Progesterone Regulates the Endoplasmic Reticulum-Associated Degradation and Unfolded Protein Response Axis by Mimicking the Androgenic Stimulation in Prostate Cancer Cells

[Molecular Biology Reports] The mode of action of progesterone on endoplasmic reticulum-associated degradation, unfolded protein response, and androgen receptor signaling in prostate cancer was investigated by cell culture studies using LNCaP and 22Rv1 cells.

Synthesis of Quinoline-2-Carboxylic Acid Aryl Ester and Its Apoptotic Action on PC3 Prostate Cancer Cell Line

[Applied Biochemistry and Biotechnology] Researchers synthesized an aryl ester compound from quinoline-2-carboxylic acid to evaluate its apoptotic, cell cycle blockade, and antiproliferative activity on the prostate cancer cell lines (PC3).

Experimental In Vitro, Ex Vivo, and In Vivo Models in Prostate Cancer Research

[Nature Reviews Urology] Preclinical prostate cancer models include standard, genetically modified and patient-derived cell lines, spheroid and organoid culture models, scaffold and hydrogel cultures, tissue slices, tumor xenograft models, patient-derived xenograft and circulating tumour cell eXplant models, as well as transgenic and knockout mouse models.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.