Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Tumor Evolution Metrics Predict Recurrence beyond 10 Years in Locally Advanced Prostate Cancer

[Nature Cancer] The authors mapped genomic intratumor heterogeneity in locally advanced prostate cancer using 642 samples from 114 individuals enrolled in clinical trials with a 12-year median follow-up.

Metabolic Adaptations in Prostate Cancer

[British Journal of Cancer] Scientists provide a comprehensive perspective on the metabolic adaptations that support prostate cancer progression beyond androgen signalling, with a particular focus on tumour cell intrinsic and extrinsic pathways.

Biological Determinants of PSMA Expression, Regulation and Heterogeneity in Prostate Cancer

[Nature Reviews Urology] Understanding the biological determinants of cell surface target regulation and heterogeneity can inform precision medicine approaches to prostate-specific membrane antigen theranostics as well as other emerging therapies.

Elevating PLK1 Overcomes BETi Resistance in Prostate Cancer via Triggering BRD4 Phosphorylation-Dependent Degradation in Mitosis

[Cell Reports] Investigators reported that bromodomain-containing protein 4 (BRD4) protein levels were significantly decreased during mitosis in a polo-like kinase 1 (PLK1)-dependent manner.

Prostate Tissue Ablation and Drug Delivery by an Image-Guided Injectable Ionic Liquid in Ex Vivo and In Vivo Models

[Science Translational Medicine] Researchers developed and optimized an injectable compound, prostate ablation and drug delivery agent, for percutaneous prostate tissue ablation and concurrently delivered therapeutic agents.

The Marine-Derived HIF-1α Inhibitor, Yardenone 2, Reduces Prostate Cancer Cell Proliferation by Targeting HIF-1 Target Genes

[Cellular & Molecular Biology Letters] The authors characterized novel hypoxia-inducible factor (HIF)-1α inhibitors including Sodwanones A, B, C, G, and Yardenone 2 isolated from marine sponges belonging to the Axinella genus.

A Vitamin D-based Strategy Overcomes Chemoresistance in Prostate Cancer

[British Journal of Pharmacology] Structure function relationships of potent vitamin D analogs were determined. The combination of the most potent analogue and docetaxel was explored in chemoresistant primary prostate cancer spheroids and in a xenograft mouse model derived from a patient with a chemoresistant CRPC.

SHP2 as a Primordial Epigenetic Enzyme Expunges Histone H3 pTyr-54 to Amend Androgen Receptor Homeostasis

[Nature Communications] Scientists uncovered that SHP2 was a distinct class of an epigenetic enzyme; upon phosphorylation by the kinase ACK1/TNK2, pSHP2 was escorted by androgen receptor (AR) to chromatin, erasing hitherto unidentified phosphorylation of histones H3 at Tyr54 epigenetic marks to trigger a transcriptional program of AR.

Circulating Tumor Extracellular Vesicles to Monitor Metastatic Prostate Cancer Genomics and Transcriptomic Evolution

[Cancer Cell] Genomic and transcriptomic profiling of circulating extracellular vesicle (EV)-DNA and EV-RNA isolated from in vitro and in vivo models of metastatic prostate cancer revealed a high contribution of tumor material to EV-loaded DNA/RNA.

Medical College of Wisconsin Set to Lead Key Initiative as Part of EDA Tech Hub Phase II Funding

[Wisconsin BioHealth Tech Hub (PR Newswire)] The US Economic Development Administration has awarded $49 million to the Wisconsin BioHealth Tech Hub, a transformative initiative to make Wisconsin a national leader in personalized medicine by accelerating biomedical innovation, growing jobs, and bringing new products to market.

Astragaloside Ⅳ Mediates the Effect and Mechanism of KPNB1 on Biological Behavior and Tumor Growth in Prostate Cancer

[Heliyon] Human prostate cancer and normal cells were obtained and karyopherin subunit beta 1 (KPNB1) expression levels in the two cells were determined using qPCR and WB.

Asparagine Dependency Is a Targetable Metabolic Vulnerability in TP53-Altered Castration-Resistant Prostate Cancer

[Cancer Research] Using transcriptomic and metabolomic analyses, scientists showed that TP53-altered prostate cancer exhibited an increased dependency on asparagine and overexpressed asparagine synthetase, the enzyme catalyzing the synthesis of asparagine.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.

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