The authors performed a kinome-scale CRISPR/Cas9 screen and identified cyclin-dependent kinase 12 (CDK12) as being conservatively required for PCa cell survival.
[Cell Death & Disease]
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Researchers characterized the biodistribution and pharmacokinetics of [68Ga]PSMA-11 in prostate-specific membrane antigen (PSMA)-positive and negative tumor-bearing mice and subsequently estimated its internal radiation dosimetry via voxel-level dosimetry using a dedicated Monte Carlo simulation to evaluate the absorbed dose in the tumor directly.
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Scientists interrogated the regulation of RE1-silencing transcription factor, a transcriptional repressor of neuronal genes, and elucidated molecular programs driving amphicrine prostate cancer and neuroendocrine prostate cancer biology.
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The relevance of pleckstrin homology-like domain family A, member 3 (PHLDA3) in prostate cancer has not been explored. Scientists illustrated the possible roles and mechanisms of PHLDA3 in prostate cancer.
[Biochemical and Biophysical Research Communications]
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Since inorganic arsenic targets prostatic stem cells, researchers hypothesized that arsenic-transformed stem cells show an impaired TLR3-associated anti-tumor pathway and, therefore, are unresponsive to polyinosinic:polycytidylic acid activation.
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Scientists proposed that alterations in DNA damage response pathway contributed to taxane resistance, and identification of these alterations may provide a potential therapeutic target to resensitize docetaxel-refractory mCRPC to taxane-based therapy.
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Investigators determined effects of LOC100996425 on human prostate cancer by targeting hepatocyte nuclear factor 4A via the AMPK/mTOR pathway.
[Journal of Cellular and Molecular Medicine]
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Investigators developed a sandwich ELISA to detect prostate-specific membrane antigen on small extracellular vesicles (EVs) using T-cell immunoglobulin domain and mucin domain-containing protein 4 as a capture molecule for EVs and to evaluate its diagnostic potential in urologic malignancies.
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Scientists reported that reduced death-associated protein kinase 1 (DAPK1) expression promoted stem cell-like characteristics of prostate cancer cells through activating zinc finger E-box binding homeobox-1 (ZEB1) via Hippo/YAP signaling pathway.
[Stem Cells and Development]
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Gestalt Diagnostics and Deep Bio announced their strategic relationship on the development of an integrated workflow for pathologists to use Artificial Intelligence algorithms directly within Gestalt’s PathFlow® platform. Deep Bio’s algorithm analyzes whole slide images of H&E-stained prostate core needle biopsy tissue specimens to detect and classify prostate cancer.
[Gestalt Diagnostics (Business Wire, Inc.)]
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The hsa_circ_0001747 signature was selected for further experimental verification in vitro and in vivo, which showed that downregulated hsa_circ_0001747 might facilitate prostate cancer via augmenting autophagy.
[Cell Death & Disease]
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