Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

PARP-ish: Gaps in Molecular Understanding and Clinical Trials Targeting PARP Exacerbate Racial Disparities in Prostate Cancer

[Cancer Research] Investigators explore PARP nuclear functions, inhibition, and clinical relevance through the lens of racial differences.

ELK3 Destabilization by Speckle-Type Poz Protein Suppresses Prostate Cancer Progression and Docetaxel Resistance

[Cell Death & Disease] Researchers found that speckle-type POZ protein (SPOP)n and ELK3 were an interacting partner. The interaction between SPOP and ELK3 resulted in increased ELK3 ubiquitination and destruction, assisted by checkpoint kinase-mediated ELK3 phosphorylation.

Phospholipase PLA2G7 Is Complementary to GPX4 in Mitigating Punicic Acid Induced Ferroptosis in Prostate Cancer Cells

[iScience] The authors investigated the mechanisms underlying the toxicity of punicic acid, an isomer of conjugated linolenic acids bearing three conjugated double bonds highly prone to peroxidation, on prostate cancer cells.

FOXA1 Regulates Ribosomal RNA Transcription in Prostate Cancer

[The Prostate] Nucleolar proteomics data and large-scale immunofluorescence were re-analyzed to jointly identify the proteins localized at nucleolus. RNA-Seq data of five prostate cancer (PCa) cohorts were combined and integrated with multi-dimensional data to define the upregulated nucleolar transcription factors in PCa tissues.

A New Hope for Men with Metastatic Prostate Cancer

[McGill University Health Centre] The Research Institute of McGill University Health Centre has enrolled the first patients to take part in an early-stage, multi-centre clinical trial of Actinium-225, a radioactive isotope used as a treatment for metastatic prostate cancer.

Uq Researcher Dr Kevin Koo Awarded Prostate Cancer Foundation of Australia Research Grant

[The University of Queensland] Dr Kevin Koo, from The University of Queensland’s (UQ) Centre for Clinical Research, has been awarded one of five new research grants worth a combined value of $1.2 million from the Prostate Cancer Foundation of Australia.

Tumor Promoting Effect of Spheroids in an Orthotopic Prostate Cancer Mouse Model

[Scientific Reports] Investigators established a technique for intraprostatic implantation of prostate cancer (PCa) spheroids and to identify the impact of three-dimensional organization of PCa cells on tumor progression and metastasis in a representative in vivo model.

Unlocking Ferroptosis in Prostate Cancer — the Road to Novel Therapies and Imaging Markers

[Nature Reviews Urology] The authors describe novel molecular underpinnings and metabolic drivers of ferroptosis, analyze the functions and mechanisms of ferroptosis in tumors, and highlight prostate cancer-specific susceptibilities to ferroptosis.

Blocking Lipid Synthesis Induces DNA Damage in Prostate Cancer and Increases Cell Death Caused by PARP Inhibition

[Science Signaling] Researchers found that combining a fatty acid synthase (FASN)i with the poly-ADP ribose polymerase (PARP) inhibitor olaparib, which induced cell death by blocking DNA damage repair, resulted in a more pronounced reduction in cell growth than that caused by either drug alone.

An Orthotopic Prostate Cancer Model for New Treatment Development Using Syngeneic or Patient-Derived Tumors

[The Prostate] Scientists described a novel micro-surgical technique for orthotopically implanting intact tumors pieces from cell line derived or patient derived tumors in the mouse prostate gland and monitoring tumor growth using magnetic resonance imaging.

An Integrated ceRNA Network Identifies miR-375 as an Upregulated miRNA Playing a Tumor Suppressive Role in Aggressive Prostate Cancer

[Oncogene] Researchers utilized stringent in silico methods to construct a large ceRNA network across different prostate cancer stages, and provided experimental demonstration for the competing regulation among protumorigenic SEC23A, PHTF2, and their corresponding ceRNA pairs.

Stem Cell Dynamics and Cellular Heterogeneity across Lineage Subtypes of Castrate Resistant Prostate Cancer

[Stem Cells] To gain biological insight and to identify potential treatment targets within heterogeneous tumor cell populations, researchers assessed the lineage hierarchy and molecular characteristics of various CRPC tumor subpopulations.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.