Researchers investigated the functional role and molecular mechanisms of SNHG11 in prostate cancer (PCa) progression. It was revealed that the SNHG11 expression levels were significantly upregulated in PCa tissues, in comparison with those in adjacent normal tissues.
[International Journal of Molecular Sciences]
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Researchers from Cardiff University have received a grant worth over £230,000 from leading men’s health charity Prostate Cancer UK. The funding will help them develop a deeper understanding of how prostate cancer affects the immune system, so it’s clearer which men could benefit from powerful new immunotherapy treatments.
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The authors highlight the latest research progress made in the biological functions and regulation of PIWI‑interacting RNA in mammals, their involvement in various cancer forms and their potential clinical applications.
From the natural product screening, the novel compound arabilin was isolated from Streptomyces sp. MK756-CF1. Unlike STK765173, arabilin could overcome resistance to enzalutamide.
[Journal of Antibiotics]
The authors performed a kinome-scale CRISPR/Cas9 screen and identified cyclin-dependent kinase 12 (CDK12) as being conservatively required for PCa cell survival.
[Cell Death & Disease]
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Researchers characterized the biodistribution and pharmacokinetics of [68Ga]PSMA-11 in prostate-specific membrane antigen (PSMA)-positive and negative tumor-bearing mice and subsequently estimated its internal radiation dosimetry via voxel-level dosimetry using a dedicated Monte Carlo simulation to evaluate the absorbed dose in the tumor directly.
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Scientists interrogated the regulation of RE1-silencing transcription factor, a transcriptional repressor of neuronal genes, and elucidated molecular programs driving amphicrine prostate cancer and neuroendocrine prostate cancer biology.
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The relevance of pleckstrin homology-like domain family A, member 3 (PHLDA3) in prostate cancer has not been explored. Scientists illustrated the possible roles and mechanisms of PHLDA3 in prostate cancer.
[Biochemical and Biophysical Research Communications]
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Since inorganic arsenic targets prostatic stem cells, researchers hypothesized that arsenic-transformed stem cells show an impaired TLR3-associated anti-tumor pathway and, therefore, are unresponsive to polyinosinic:polycytidylic acid activation.
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Scientists proposed that alterations in DNA damage response pathway contributed to taxane resistance, and identification of these alterations may provide a potential therapeutic target to resensitize docetaxel-refractory mCRPC to taxane-based therapy.
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Investigators determined effects of LOC100996425 on human prostate cancer by targeting hepatocyte nuclear factor 4A via the AMPK/mTOR pathway.
[Journal of Cellular and Molecular Medicine]
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