Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Small-Molecule Disruption of Androgen Receptor–Dependent Chromatin Clusters

November 29, 2024

[Proceedings of The National Academy of Sciences of The United States of America] Scientists reported androgen receptor (AR) antagonists with efficacy in AR-overexpressing models. These molecules bound to the ligand-binding domain of the AR, promote AR localization to the nucleus, yet potently and selectively down-regulated AR-target genes.

The Potential of TRP Channels as New Prognostic and Therapeutic Targets Against Prostate Cancer Progression

November 28, 2024

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors discuss the contribution of Transient Receptor Potential channels in hallmarks of prrostate cancer (PCa), and then discuss their applicability as new prognostic and therapeutic agents in the fight against metastatic PCa.

Cancer Targeted Technology Receives Fast Track $2.4M Grant to Develop an Innovative PSMA-Targeted Small Molecule Drug Conjugate for Prostate Cancer

November 27, 2024

[Cancer Targeted Technology] Cancer Targeted Technology announced that the National Cancer Institute awarded the Phase I portion of the fast track Phase I/II Small Business Innovation Research grant to develop a new drug to treat metastatic prostate cancer.

CRIPTO’s Multifaceted Role in Driving Aggressive Prostate Cancer Unveiled by In Vivo, Organoid, and Patient Data

November 26, 2024

[Oncogene] Scientists demonstrated that suppressing Cripto in vivo significantly decreased invasive cell behavior in aggressive tumors, highlighting a critical oncogenic function of CRIPTO in advanced prostate cancer.

Dissecting the Novel Molecular Interactions of Solute Carrier Family 4 Member 4 (SLC4A4) for Prostate Cancer (PCa) Progression

November 26, 2024

[Scientific Reports] Scientists investigated the role of SLC4A4 and the signaling mechanism underlying its role in modulating the prostate cancer progression.

PGC-1α Drives Small Cell Neuroendocrine Cancer Progression Toward an ASCL1-Expressing Subtype with Increased Mitochondrial Capacity

November 26, 2024

[Proceedings of The National Academy of Sciences of The United States of America] Analyses using a human prostate tissue-based small cell neuroendocrine transformation system showed that the achaete-scute homolog 1 (ASCL1) subtype heightened PGC-1α expression and oxidative phosphorylation activity.

A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity Against Prostate Cancer

November 22, 2024

[Cancer Immunology Research] Scientists reported that the prostate-specific membrane antigen (PSMA) Tri-specific Killer Engager specifically bound to PSMA-expressing cells and significantly enhanced expansion, degranulation, and cytokine production of NK cells derived from healthy donors or prostate cancer patients.

Osteoblast-Derived ECM1 Promotes Anti-Androgen Resistance in Bone Metastatic Prostate Cancer

November 22, 2024

[Advanced Science] Researchers demonstrated that under enzalutamide treatment, osteoblasts in the bone microenvironment secrete increased levels of extracellular matrix protein 1 (ECM1), which affected surrounding prostate cancer cells, promoting tumor cell proliferation and anti-androgen resistance.

Elucidating Acquired PARP Inhibitor Resistance in Advanced Prostate Cancer

November 22, 2024

[Cancer Cell] Evaluating samples from patients with metastatic CRPC treated in the TOPARP-B trial, the authors identifed reversion mutations in most BRCA2/PALB2-mutated tumors by end of treatment.

Low Tristetraprolin Expression Activates Phenotypic Plasticity and Primes Transition to Lethal Prostate Cancer in Mice

November 20, 2024

[Journal of Clinical Investigation] Scientists reported that that loss of tristetraprolin (TTP) increased NF-κB activation, and was associated with higher rates of aggressive disease and early recurrence in primary prostate cancer.

CHD6 Eviction of Promoter Nucleosomes Maintains Housekeeping Transcriptional Program in Prostate Cancer

November 19, 2024

[Molecular Therapy - Nucleic Acids] Investigators discovered sharp peaks of CHD6, as the first member of CHD family for housekeeping process, binding only to the promoter region of genes in C4-2 cell line. These genes, with conserved sharp CHD6 peaks across tumor cells, likely represented housekeeping genes ADNP and GOLGA5.

Transcription and DNA Replication Collisions Lead to Large Tandem Duplications and Expose Targetable Therapeutic Vulnerabilities in Cancer

November 18, 2024

[Nature Cancer] Researchers used 6,193 whole-genome sequenced tumors to study the contributions of transcription and DNA replication collisions to genome instability. Large tandem duplications were abundant in female-enriched, upper gastrointestinal tract, and prostate cancers.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.