Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway

January 13, 2025

[Advanced Science] Scientists identified key circular RNAs linked to prostate cancer progression and enzalutamide resistance. It was found that hsa_circ_0005185 interacted with OTUB1 and RAB8A, serving as a molecular scaffold.

NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

January 13, 2025

[Clinical Cancer Research] Researchers reported that in multiple CRPC transcriptome cohorts the GO Cellular Response to Heat gene expression signature associated with androgen receptor signaling and worse clinical outcome. They demonstrated the effects of targeting the HSF1 pathway with an inhibitor in clinical development in prostate cancer.

PlexinD1 Is a Driver and a Therapeutic Target in Advanced Prostate Cancer

January 6, 2025

[EMBO Molecular Medicine] Scientists identified the axon guidance semaphorin receptor PlexinD1 as a crucial driver of cancer aggressiveness in metastatic CRPC. High PlexinD1 expression in human prostate cancer was correlated with adverse clinical outcomes.

Tumor-Intrinsic Regulators of the Immune-Cold Microenvironment of Prostate Cancer

January 6, 2025

[Trends In Endocrinology and Metabolism] Researchers discuss various genetic and epigenetic regulators intrinsic to prostate tumor cells that could have profound effects on the tumor microenvironment, thus contributing to an immune-cold status.

UMMC Receives $1.4 Million Grant for Prostate Cancer Research

January 3, 2025

[UMMC] The University of Mississippi Medical Center (UMMC) Cancer Center and Research Institute received a $1.4 million grant from the US Department of Defense to examine the biological factors contributing to prostate cancer and racial disparities in outcomes.

LKB1 Inactivation Promotes Epigenetic Remodeling-Induced Lineage Plasticity and Antiandrogen Resistance in Prostate Cancer

January 2, 2025

[Cell Research] Utilizing single-cell RNA sequencing on both human and mouse prostate cancer samples, combined with whole-genome bisulfite sequencing and multiple genetically engineered mouse models, researchers investigated the molecular mechanism of androgen receptor-independent lineage plasticity and uncovered a potential therapeutic strategy.

PSCA-Targeted BPX-601 CAR T Cells with Pharmacological Activation by Rimiducid in Metastatic Pancreatic and Prostate Cancer: A Phase I Dose Escalation Trial

January 2, 2025

[Nature Communications] Investigators reported results of a Phase I open-label, dose-escalation trial of BPX-601, an investigational autologous prostate stem cell antigen (PSCA)-directed GoCAR-T® cell product containing an inducible MyD88/CD40 ON-switch responsive to the activating dimerizer rimiducid, in patients with metastatic CRPC.

Survival Outcomes of Apalutamide as a Starting Treatment: Impact in Real-World Patients With Metastatic Hormone Sensitive Prostate Cancer (OASIS)

December 23, 2024

[Prostate Cancer and Prostatic Diseases] Scientists evaluated the impact of upfront therapy for metastatic hormone-sensitive prostate cancer on outcomes in real-world clinical practice in the United States.

A TBX2-Driven Signaling Switch From Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

December 23, 2024

[Oncogene] Using human prostate cancer and CRPC cell line models, scientists demonstrated that TBX2 downregulated androgen receptor and upregulated glucocorticoid receptor through direct transcriptional regulation.

Radiotherapy-Resistant Prostate Cancer Cells Escape Immune Checkpoint Blockade through the Senescence-Related Ataxia Telangiectasia and Rad3-Related Protein

December 23, 2024

[Cancer Communications] Scientists identified a subset of prostate cancer cells that exhibited resistance to radiotherapy, characterized by a reduced antigen presentation capability, which enhanced their ability to evade immune detection and resist cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade.

Collagen Signaling and Matrix Stiffness Regulate Multipotency in Glandular Epithelial Stem Cells in Mice

December 18, 2024

[Nature Communications] Researchers found that Collagen I expression was commonly upregulated in adult basal stem cells (BaSCs) across the different multipotent conditions. Increasing collagen concentration or stiffness of the ECM promoted BaSC multipotency in mammary gland and prostate organoids.

Patient-Reported Outcomes of Rezvilutamide Versus Bicalutamide in Combination with Androgen Deprivation Therapy in High-Volume Metastatic Hormone-Sensitive Prostate Cancer Patients (CHART): A Randomized, Phase III...

December 18, 2024

[Signal Transduction and Targeted Therapy] The randomized Phase III CHART trial revealed that rezvilutamide plus androgen deprivation therapy in high-volume, metastatic, hormone-sensitive prostate cancer significantly enhanced radiographic progression-free and overall survival than bicalutamide.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.