Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Prevalence of Mismatch Repair Deficiency in Primary Prostate Cancer in a Large Prospective Cohort

March 20, 2025

[Clinical Cancer Research] This study included 1,016 men diagnosed with primary prostate cancer during prospective follow-up of the Health Professionals Follow-up Study and Physicians’ Health Study.

Single-Cell and Spatial Transcriptomics Reveal a Tumor-Associated Macrophage Subpopulation That Mediates Prostate Cancer Progression and Metastasis

March 19, 2025

[Molecular Cancer Research] The authors integrated parallel datasets from single-cell RNA-sequencing, spatial transcriptomics, and multiplex immunofluorescence to reveal the dynamics of tumor-associated macrophages in primary and metastatic prostate cancer.

The Kinase PLK1 Promotes Hedgehog Signaling-Dependent Resistance to the Antiandrogen Enzalutamide in Metastatic Prostate Cancer

March 19, 2025

[Science Signaling] Researchers found that programmed cell death 4 was repressed by the mitotic kinase polo-like kinase 1 (PLK1), which enabled the activity of cell survival pathways that are androgen independent.

Targeting the Histone Reader ZMYND8 Inhibits Antiandrogen-Induced Neuroendocrine Tumor Transdifferentiation of Prostate Cancer

March 18, 2025

[Nature Cancer] Scientists combined CRISPR‒Cas9 screening with single-cell RNA sequencing tracking of tumor transition and demonstrated that antiandrogen-induced zinc finger MYND-type containing 8 (ZMYND8)-dependent epigenetic programming orchestrates neuroendocrine prostate cancer transdifferentiation.

Atractylenolide I Ameliorated the Growth and Enzalutamide Resistance of Castration-Resistant Prostate Cancer by Targeting KIF15

March 14, 2025

[Chinese Medicine] An enzalutamide-resistant cell line was successfully constructed. CCK-8, EdU, wound healing, Transwell assays, flow cytometry, and xenograft tumor models were applied to investigate the antitumor activity of atractylenolide I against CRPC.

Enhancer Transcription Profiling Reveals an Enhancer RNA-Driven Ferroptosis and New Therapeutic Opportunities in Prostate Cancer

March 14, 2025

[Signal Transduction and Targeted Therapy] Researchers performed integrated chromatin accessibility and transcriptomic analyses using ATAC-seq and RNA-seq on twenty pairs of prostate cancer and matched benign tissues.

The Impact of Dysregulation SUMOylation on Prostate Cancer

March 14, 2025

[Journal of Translational Medicine] Scientists explore the mechanisms by which SUMOylation is implicated in the regulation of key pathways, and summarize aberrant expression of SUMO-related enzymes or SUMOylation sites mutations of substrtes in prostate cancer.

£2m Trial Will Test Whether New Scan Could Stop High-Risk Prostate Cancer from Spreading

March 14, 2025

[Imperial College Healthcare] A new kind of scan that could improve the treatment of high-risk prostate cancer compared with the scans currently used will be tested in a new £1.89 million clinical trial led by consultant urological surgeon Professor Hashim Ahmed.

S-Methyl Methanethiosulfonate, the Main Human Metabolite of S-Methyl-L-Cysteine Sulfoxide, Alters Energy Metabolism in Prostate Cancer Cells

March 13, 2025

[Molecular Nutrition & Food Research] The authors investigated the metabolic effects of S-methyl-L-cysteine-sulfoxide and its metabolite, S-methyl methanethiosulfonate, on prostate cancer metabolism.

Heat Shock Protein Family A Member 1A Attenuates Apoptosis and Oxidative Stress via ERK/JNK Pathway in Hyperplastic Prostate

March 13, 2025

[MedComm] In vitro experiments elucidated that heat shock protein family A member 1A was localized in prostatic epithelium and stroma, with upregulated expression in benign prostatic hyperplasia tissues.

Emerin Dysregulation Drives the Very-Small-Nuclear Phenotype and Lineage Plasticity that Associates with a Clinically Aggressive Subtype of Prostate Cancer

March 11, 2025

[Clinical Cancer Research] Scientists investigated the correlation between reduction of emerin expression and circulating tumor cells with a very-small-nuclear phenotype and its clinical impact.

PCBP2 Promotes Immune Evasion Via cGAS-STING Pathway in Biochemical Recurrence of Prostate Cancer

March 7, 2025

[APL Bioengineering] Investigators explored cancer-intrinsic immune evasion-related genes in prostate cancer and developed a predictive signature for biochemical recurrence.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.