Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Ellagic Acid Improves Benign Prostate Hyperplasia by Regulating Androgen Signaling and STAT3

[Cell Death & Disease] To investigate the effect of ellagic acid (EA) on benign prostate hyperplasia, scientists used EA, a phytochemical abundant in fruits and vegetables, to treat testosterone propionate-induced BPH rats and RWPE-1 human prostate epithelial cells.

Identification of Prostate Cancer Subtypes Based on Immune Signature Scores in Bulk and Single-Cell Transcriptomes

[Medical Oncology] Researchers identified two prostate cancer (PC) subtypes: PC immunity high and PC immunity low, consistently in these datasets.

Leptin Modulated MicroRNA-628-5p Targets Jagged-1 and Inhibits Prostate Cancer Hallmarks

[Scientific Reports] Investigators examined the detailed cellular phenotypes and pathways regulated by miR-628 in prostate cancer cells.

Hippo Pathway Monomerizes STAT3 to Regulate Prostate Cancer Growth

[Cancer Science] Scientists showed that high cell density-mediated activation of Hippo pathway blunted STAT3 activity in prostate cancer cells.

CKAP2L, a Crucial Target of miR-326, Promotes Prostate Cancer Progression

[BMC Cancer] CKAP2L expression was examined in the normal and tumor tissues of prostate cancer patients with RT-QPCR and Western blot.

Dual STAT-3 and IL-6R Inhibition with Stattic and Tocilizumab Decreases Migration, Invasion and Proliferation of Prostate Cancer Cells by Targeting the IL-6/IL-6R/STAT-3 Axis

[Oncology Reports] Researchers investigated the effect of Stattic + Tocilizumab on proliferative, clonogenic, migratory and invasive ability of human metastatic prostate cancer, as assessed by colony formation, wound healing and migration assay.

$3.5M Study to Better Predict Prostate Cancer Risk

[University of Hawai'i News] To increase public understanding of the causes of prostate cancer, the University of Hawaiʻi Cancer Center will lead a $3.5 million public impact research study to further our understanding of prostate cancer to improve prediction of future disease.

miR-27 and miR-124 Target AR Coregulators in Prostate Cancer: Bioinformatics and In Vitro Analysis

[Andrologia] The authors identified miRNAs targeting androgen receptor (AR) coregulators. They examined target genes by combining miRNA-mRNA computational and experimental data from various databases.

Androgen and Androgen Receptor Control of Mitochondrial Function

[American Journal of Physiology-Cell Physiology] The authors highlight the effects that androgens have on mitochondrial structure and function with emphasis on biogenesis, fusion/fission, mitophagy, bioenergetics, and reactive oxygen species production.

Prostate Organogenesis

[Development] The fields of developmental and cancer biology have long been interested in prostate organogenesis because of its relevance for understanding prostate disease.

Chronologically Modified Androgen Receptor in Recurrent Castration-Resistant Prostate Cancer and Its Therapeutic Targeting

[Science Translational Medicine] ACK1 kinase–mediated AR Y267 phosphorylation was a prerequisite for AR K609 acetylation, which spawned positive feedback loops at both the transcriptional and posttranslational level that regenerated and sustained high androgen receptor and ACK1 expression.

α-Terthienyl Induces Prostate Cancer Cell Death through Inhibiting Androgen Receptor Expression

[Biomedicine & Pharmacotherapy] Scientists found α- terthienyl could inhibit the cell viability of four prostate cancer cell lines, especially on LNCaP and 22Rv1 cells which endogenously express androgen receptor.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.