Inhibition of TMPRSS2 by HAI-2 Reduces Prostate Cancer Cell Invasion and Metastasis

Hepatocyte growth factor activator inhibitor-2 overexpression could suppress the induction effect of TMPRSS2 on pro-HGF activation and prostate cancer cell invasion.
[Oncogene]
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NIH Grants $1.44M to Cancer Targeted Technology to Support the Ongoing Prostate Cancer Clinical Trial of a Promising New Radiotherapeutic, CTT1403

Cancer Targeted Technology announced that the NIH awarded CTT $1.44M on the second year of a competitive Small Business Innovation Research Phase IIB grant.
[Cancer Targeted Technology (Business Wire, Inc.)]
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Current Status and Future Perspectives of Checkpoint Inhibitor Immunotherapy for Prostate Cancer: A Comprehensive Review

Researchers review the current status of immunotherapy, including new discoveries and precision approaches to prostate cancer, and discuss future directions in the continuously evolving landscape of immunotherapy.
[International Journal of Molecular Sciences]
Kim, T. J., & Koo, K. C. (2020). Current Status and Future Perspectives of Checkpoint Inhibitor Immunotherapy for Prostate Cancer: A Comprehensive Review. International Journal of Molecular Sciences, 21(15), 5484. https://doi.org/10.3390/ijms21155484 Cite
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Chelerythrine Suppresses Proliferation and Metastasis of Human Prostate Cancer Cells via Modulating MMP/TIMP/NF-κB System

The addition of chelerythrine significantly inhibited the proliferation of androgen-independent prostate cancer DU145 and PC-3 cells at the concentration of 5 and 10 μM, but not on androgen-dependent prostate cancer LNCaP cells as well as normal prostate epithelial cell line PrEC cells.
[Molecular and Cellular Biochemistry]
Yang, B., Zhang, D., Qian, J., & Cheng, Y. (2020). Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-κB system. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-020-03845-0 Cite
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ORIC Pharmaceuticals Expands Precision Oncology Pipeline with Exclusive Worldwide License to Highly Selective Allosteric PRC2 Inhibitors from Mirati Therapeutics

ORIC Pharmaceuticals, Inc. announced it has entered into an exclusive worldwide license agreement with Mirati Therapeutics, Inc. ORIC will have exclusive worldwide rights for the development activities and commercialization of a small molecule allosteric inhibitor program directed towards the polycomb repressive complex 2, a validated oncogenic target across several cancers with promising therapeutic potential in prostate cancer, among other indications.
[ORIC Pharmaceuticals, Inc.]
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Curcumin Nanoparticles and Their Cytotoxicity in Docetaxel-Resistant Castration-Resistant Prostate Cancer Cells

Scientists developed curcumin nanoparticles and evaluated their cytotoxicity in docetaxel (DTX)-resistant castration-resistant prostate cancer (CRPC) cells for the treatment of DTX-resistant CRPC.
[Biomedicines]
Tanaudommongkon, I., Tanaudommongkon, A., Prathipati, P., Nguyen, J. T., Keller, E. T., & Dong, X. (2020). Curcumin Nanoparticles and Their Cytotoxicity in Docetaxel-Resistant Castration-Resistant Prostate Cancer Cells. Biomedicines, 8(8), 253. https://doi.org/10.3390/biomedicines8080253 Cite
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Predicting New Drug Indications for Prostate Cancer: The Integration of an In Silico Proteochemometric Network Pharmacology Platform with Patient‐Derived Primary Prostate Cells

Researchers integrated a computational proteochemometric systems network pharmacology platform, DrugGenEx‐Net, with primary, continuous cultures of conditionally reprogrammed normal and prostate cancer (PCa) cells derived from treatment‐naive patients with primary PCa.
[Prostate]
Naeem, A., Dakshanamurthy, S., Walthieu, H., Parasido, E., Avantaggiati, M., Tricoli, L., Kumar, D., Lee, R. J., Feldman, A., Noon, M. S., Byers, S., Rodriguez, O., & Albanese, C. (n.d.). Predicting new drug indications for prostate cancer: The integration of an in silico proteochemometric network pharmacology platform with patient-derived primary prostate cells. The Prostate, n/a(n/a). https://doi.org/10.1002/pros.24050 Cite
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Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice

Scientists determined the effects of grape antioxidants quercetin and/or resveratrol against prostate cancer in the transgenic adenocarcinoma of mouse prostate (TRAMP)-model in prevention and intervention settings.
[Cancers]
Singh, C. K., Chhabra, G., Ndiaye, M. A., Siddiqui, I. A., Panackal, J. E., Mintie, C. A., & Ahmad, N. (2020). Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice. Cancers, 12(8), 2141. https://doi.org/10.3390/cancers12082141 Cite
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The Prostaglandin Synthases, COX-2 and L-PGDS, Mediate Prostate Hyperplasia Induced by Low-Dose Bisphenol A

In vitro studies showed that low-dose bisphenol A promoted the proliferation of human prostate fibroblasts and epithelial cells, and significantly upregulated the expression of cyclooxygenase-2 (COX-2) and L-PGDS in the cells.
[Scientific Reports]
Wu, S., Huang, D., Su, X., Yan, H., Ma, A., Li, L., Wu, J., & Sun, Z. (2020). The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A. Scientific Reports, 10(1), 13108. https://doi.org/10.1038/s41598-020-69809-y Cite
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The Spectrum of Design Solutions for Improving the Activity-Selectivity Product of Peptide Antibiotics against Multidrug-Resistant Bacteria and Prostate Cancer PC-3 Cells

Scientists hypothesized that designed peptides with a wide spectrum of selective antimicrobial activity will also have anticancer activity, and tested this hypothesis with newly designed peptides.
[Molecules]
Juretić, D., Golemac, A., Strand, D. E., Chung, K., Ilić, N., Goić-Barišić, I., & Pellay, F.-X. (2020). The Spectrum of Design Solutions for Improving the Activity-Selectivity Product of Peptide Antibiotics against Multidrug-Resistant Bacteria and Prostate Cancer PC-3 Cells. Molecules, 25(15), 3526. https://doi.org/10.3390/molecules25153526 Cite
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Mitochondrial Functional and Structural Impairment Is Involved in the Antitumor Activity of δ-Tocotrienol in Prostate Cancer Cells

The authors investigated whether δ-tocotrienol (δ-TT) might exert its activity by impairing mitochondrial functions. They demonstrated that, in PC3 and DU145 cells, δ-TT impairs mitochondrial respiration and structural dynamics.
[Free Radical Biology and Medicine]
Fontana, F., Raimondi, M., Marzagalli, M., Audano, M., Beretta, G., Procacci, P., Sartori, P., Mitro, N., & Limonta, P. (2020). Mitochondrial functional and structural impairment is involved in the antitumor activity of δ-tocotrienol in prostate cancer cells. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2020.07.009 Cite
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Twitter Account of Embattled #MeTooSTEM Founder Suspended

Twitter has suspended the account of MeTooSTEM founder BethAnn McLaughlin after allegations emerged that the former Vanderbilt University neuroscientist fabricated the Twitter account of an apparently nonexistent female Native American anthropologist at Arizona State University who had claimed to be an anonymous victim of sexual harassment by a Harvard professor.
[ScienceInsider]
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