Mechanisms of Abemaciclib, a CDK4/6 Inhibitor, Induced Apoptotic Cell Death in Prostate Cancer Cells In Vitro

Researchers analyzed in vitro cytotoxic and apoptotic effects of abemaciclib on metastatic castration-resistant prostate cancer androgen receptor negative PC-3 and AR mutant LNCaP prostate cancer cells.
[Translational Oncology]
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Dual Akt and Bcl-2 Inhibition Induces Cell-Type Specific Modulation of Apoptotic and Autophagic Signaling in Castration Resistant Prostate Cancer Cell Lines

The authors elucidated the modulation patterns between apoptosis and autophagy following dual inhibition by Akt inhibitor erufosine and Bcl-2 inhibitor ABT-737 in castration-resistant prostate cancer cell lines, PC-3 (Bax+) and DU-145 (Bax−).
[Molecular Biology Reports]
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Supraphysiological Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer

Investigators reported that supraphysiological levels of testosterone (SupraT) activated cytoplasmic nucleic acid sensors and induced growth inhibition of SupraT-sensitive prostate cancer cells.
[Cancer Research]
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Targeting KDM6A Suppresses SREBP1c-Dependent Lipid Metabolism and Prostate Tumorigenesis

Scientists reported that specific homozygous deletion of KDM6A in the adult mouse prostate epithelium strongly inhibited tumor progression initiated by the homozygous loss of PTEN. Mechanistically, KDM6A promoted prostate tumorigenesis and lipid metabolism by binding to the SREBP1c promoter which resulted in increased SREBP1c transcription.
[Cancer Research]
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Bortezomib Potentiates Antitumor Activity of Mitoxantrone through Dampening Wnt/β-Catenin Signal Pathway in Prostate Cancer Cells

Researchers determined the anticancer effects of a combination of bortezomib and mitoxantrone by apoptosis and proliferation assay in vivo and in vitro.
[BMC Cancer]
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Reorganization of the 3D Genome Pinpoints Non-coding Drivers of Primary Prostate Tumors

The authors investigated the molecular mech­­anisms of long non‑coding RNA small nucleolar RNA host gene 16 in the proliferation and metastasis of prostate cancer cells.
[Molecular Medicine Reports]
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Current Status of Organoid Culture in Urological Malignancy

The authors summarize the development and applications of three-dimensional organoid cultures in urological cancers, mainly focusing on prostate, urinary bladder and kidney cancers, and assess the future prospects of this model.
[International Journal of Urology]
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Tricol Biomedical Receives NIH Phase IIB Grant to Continue Development of its Hemostatic Device for the Prostate

Tricol Biomedical, Inc. has received an $853,585 grant from the National Institute Of Diabetes And Digestive And Kidney Diseases. This Phase IIB grant will support final development of Tricol’s proprietary hemostatic device to address bleeding in prostate-related procedures for treatment of both benign and malignant prostate conditions.
[Tricol Biomedical, Inc. (GlobeNewswire, Inc.)]
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AXL Cooperates with EGFR to Mediate Neutrophil Elastase-Induced Migration of Prostate Cancer Cells

Scientists reported that neutrophil elastase triggered dose-dependent ERK signaling and cell migration in a panel of prostate cell lines representing the spectrum of prostate cell malignancy.
[iScience]
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OXER1 Mediates Testosterone-Induced Calcium Responses in Prostate Cancer Cells

The authors reported that testosterone, independently of the presence of the classical androgen receptor, rapidly increased intracellular calcium from calcium stores, through the oxoeicosanoid receptor 1 (OXER1) and a signaling cascade that triggered calcium release from the endoplasmic reticulum.
[Molecular and Cellular Endocrinology]
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Novel Chemotherapeutic Agent FX-9 Activates NF-κB Signaling and Induces G1 Phase Arrest by Activating CDKN1A in a Human Prostate Cancer Cell Line

Investigators conducted microarray gene expression analysis and compared FX-9 exposed and unexposed prostate cancer cells, followed by pathway analysis and gene annotation to functional processes.
[BMC Cancer]
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