Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Rare Histologic Transformation of a CTNNB1 (β-Catenin) Mutated Prostate Cancer with Aggressive Clinical Course

[Diagnostic Pathology] The authors reported a rare histologic transformation of a CTNNB1 mutated metastatic castration resistant prostate cancer, clinically characterized by highly aggressive disease course.

The Clock Gene BHLHE40 and Atypical CCNG2 Control Androgen-Induced Cellular Senescence as a Novel Tumor Suppressive Pathway in Prostate Cancer

[Journal of Experimental & Clinical Cancer Research] RNA-seq and transcriptome analysis, ChIP-seq, human 3D prostate cancer (PCa) spheroids, mouse xenografted castration-resistant PCa, knockdown and overexpression, co-immunoprecipitation, translocation analysis, immune detection, qRT-PCR, and protein–protein interaction modeling were performed.

Reciprocal Regulation between RACGAP1 and AR Contributes to Endocrine Therapy Resistance in Prostate Cancer

[Cell Communication and Signaling] Bioinformatics methods were used to analyze the relationship of expression level between Rac GTPase-activating protein 1 (RACGAP1) and androgen receptor (AR) as well as AR pathway activation.

Identification of the Cytoplasmic DNA-Sensing cGAS-STING Pathway-Mediated Gene Signatures and Molecular Subtypes in Prostate Cancer

[BMC Cancer] The 430 patients with prostate cancer from the TCGA database were included. They integrated 29 key genes involved in cGAS-STING pathway and analyzed differentially expressed genes and biochemical recurrence-free survival-related genes.

Intracellular Osteopontin Promotes the Release of TNFα by Mast Cells to Restrain Neuroendocrine Prostate Cancer

The authors tested the hypothesis that mast cells (MCs) could restrain neuroendocrine prostate cancer through osteopontin production, using in vitro co-cultures between murine or...

ZFHX3 Acts as a Tumor Suppressor in Prostate Cancer by Targeting FTO-Mediated m6A Demethylation

Scientists found that zinc-finger homeobox 3 (ZFHX3) knockdown decreased total N6-methyladenosine (m6A) levels through enhancing the transcriptional activity of FTO in prostate cancer cells.

Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

Using the Hi-MYC prostate cancer mouse model, researchers demonstrated that an obesogenic high-fat diet rich in saturated fats accelerated the development of c-MYC–driven invasive...

Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

[Cancer Research] Using the Hi-MYC prostate cancer mouse model, the authors demonstrated that an obesogenic high-fat diet rich in saturated fats accelerates the development of c-MYC–driven invasive prostate cancer through metabolic rewiring.

Intracellular Osteopontin Promotes the Release of TNFα by Mast Cells to Restrain Neuroendocrine Prostate Cancer

[Cancer Immunology Research] The authors tested the hypothesis that mast cells (MCs) could restrain neuroendocrine prostate cancer through osteopontin production, using in vitro co-cultures between murine or human tumor cell lines and MCs, and in vivo experiments.

Mesenchymal Stem Cell-Derived Exosomes for Management of Prostate Cancer: An Updated View

[International Immunopharmacology] In prostate cancer, researchers have explored the fact that mesenchymal stem cell (MSC)-based therapies and MSC-derived exosomes are emerging as attractive options to improve the efficacy and safety of traditional cancer therapies.

RNASEH2B Loss and PARP Inhibition in Advanced Prostate Cancer

[Journal of Clinical Investigation] Whole tumor biopsies from multiple cohorts of patients with advanced prostate cancer were interrogated using whole-exome sequencing, RNA sequencing, and immunohistochemistry for RNASEH2B and RB1.

CAPN2 Promotes Apalutamide Resistance in Metastatic Hormone-Sensitive Prostate Cancer by Activating Protective Autophagy

[Journal of Translational Medicine] Investigators established apalutamide-resistant prostate cancer cells, and confirmed that apalutamide activated the release of calcium ions and endoplasmic reticulum stress to enhance autophagy.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.

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