Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Meta-Analyses of Mouse and Human Prostate Single-Cell Transcriptomes Reveal Widespread Epithelial Plasticity in Tissue Regression, Regeneration, and Cancer

January 20, 2025

[Genome Medicine] Scientists demonstrated transcriptomic similarities between epithelial cell states in the normal prostate, in the regressed prostate after androgen-deprivation, and in primary prostate tumors.

Can You Steam Away Prostate Cancer?

January 17, 2025

[Keck Medicine USC] Keck Medicine of University of Southern California (USC) is participating in a national, multisite clinical trial examining if a water vapor system that uses small, targeted amounts of steam to kill cancer cells is a safe and effective treatment for prostate cancer.

Prostate Cancer Epigenetics — from Pathophysiology to Clinical Application

January 16, 2025

[Nature Reviews Neurology] Advancements in technological tools to characterize the epigenome have highlighted crucial roles of epigenetic mechanisms throughout the entire spectrum of prostate cancer, from initiation to progression, including localized disease and metastatic dissemination.

Oncogenic Potential of Truncated-Gli3 via the Gsk3β/Gli3/AR-V7 Axis in Castration-Resistant Prostate Cancer

January 16, 2025

[Oncogene] Investigators unveiled a novel role of the truncated form of Gli in advancing CRPC. Knockdown of Gsk3β reduced CRPC cell proliferation, induced apoptosis via mitochondrial fragmentation, and triggered metabolomic reprogramming.

GILT Stabilizes Cofilin to Promote the Metastasis of Prostate Cancer

January 16, 2025

[Cell Death Discovery] Researchers confirmed that gamma-interferon-induced lysosomal thiol reductase (GILT) was significantly upregulated in prostate cancer (Pca) and facilitated tumor metastasis. GILT overexpression stabilized and increased the protein level of cofilin in PCa cells and promoted the metastasis of PCa cells.

Exploring B7-H4’s Role in Prostate Cancer Dormancy Post-Androgen Deprivation Therapy: Extracellular Matrix Interactions and Therapeutic Opportunities

January 16, 2025

[Molecular Cancer Research] Using prostate cancer patient-derived xenograft dormancy models, researchers investigated the critical dormant phase and discovered a selective increase in B7-H4 expression during the dormancy period following mouse host castration.

CXCL14 in Prostate Cancer: Complex Interactions in the Tumor Microenvironment and Future Prospects

January 16, 2025

[Journal of Translational Medicine] Scientists discuss the role of CXCL14 in the tumor microenvironment of prostate cancer and explore future research directions and potential applications.

Elucidating the Role of Pyrimidine Metabolism in Prostate Cancer and Its Therapeutic Implications

January 15, 2025

[Scientific Reports] Through transcriptomic and single-cell RNA sequencing analyses, researchers explored metabolic pathway enrichment, immune infiltration patterns, and differential gene expression in prostate cancer samples.

Ontario First in Canada to Administer New Publicly Funded Prostate Cancer Care Treatment

January 15, 2025

[Ontario Newsroom] The Ontario government is connecting more people to care by being the first Canadian jurisdiction to publicly fund and administer PLUVICTO™ a new treatment for advanced-stage prostate cancer, which is now covered under the province’s publicly funded drug program.

Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway

January 13, 2025

[Advanced Science] Scientists identified key circular RNAs linked to prostate cancer progression and enzalutamide resistance. It was found that hsa_circ_0005185 interacted with OTUB1 and RAB8A, serving as a molecular scaffold.

NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

January 13, 2025

[Clinical Cancer Research] Researchers reported that in multiple CRPC transcriptome cohorts the GO Cellular Response to Heat gene expression signature associated with androgen receptor signaling and worse clinical outcome. They demonstrated the effects of targeting the HSF1 pathway with an inhibitor in clinical development in prostate cancer.

PlexinD1 Is a Driver and a Therapeutic Target in Advanced Prostate Cancer

January 6, 2025

[EMBO Molecular Medicine] Scientists identified the axon guidance semaphorin receptor PlexinD1 as a crucial driver of cancer aggressiveness in metastatic CRPC. High PlexinD1 expression in human prostate cancer was correlated with adverse clinical outcomes.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.