Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Homologous Recombination Repair Status in Metastatic Prostate Cancer by Next-Generation Sequencing and Functional Immunofluorescence

[Cell Reports Medicine] Scientists investigated the association between genomic and functional loss of homologous recombination repair, using next-generation sequencing and RAD51 immunofluorescence in 219 primary or metastatic biopsies from 187 patients with stage IV prostate cancer.

Comparative Transcriptomics Reveals a Mixed Basal, Club, and Hillock Epithelial Cell Identity in Castration-Resistant Prostate Cancer

[Proceedings of The National Academy of Sciences of The United States of America] The authors showed that double-negative CRPC cells expressed genes defining basal, club, and hillock epithelial cells from benign prostate.

Pfizer Canada and Partners Announce Quality Improvement Grant Recipients for Canada’s Most Prevalent Cancers

[Pfizer (Canada Newswire)] Pfizer Canada, together with Rethink Breast Cancer, Colorectal Cancer Canada, Lung Health Foundation, Lung Cancer Canada, and the Quebec Lung Association, announced the 2024 recipients of a series of grants to help advance oncology care and innovation in Canada.

High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes

[Cancer Discovery] Utilizing a novel circulating tumor cell (CTC) isolation approach, scientists collected 273 CTC samples from 117 patients with metastatic prostate cancer for RNA sequencing. 146 samples from 70 patients had tumor purity comparable to tissue biopsies.

Identification of Mitochondrial Carrier Homolog 2 as an Important Therapeutic Target of Castration-Resistant Prostate Cancer

[Cell Death & Disease] The authors investigated the expression of the mitochondrial carrier homolog 2 and its potential function in castration-resistant prostate cancer.

ATAD2 Drives Prostate Cancer Progression to Metastasis

[Molecular Cancer Research] Researchers employed genetically engineered mouse models of prostate cancer bone metastasis, as well as multiple independent human cohorts, to show that ATAD2 was highly enriched in bone metastasis compared to primary tumors.

JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer

[Cancer Research] Investigators found that aberrant accumulation of jumonji domain containing 6 (JMJD6) proteins correlated with poorer prognosis of prostate cancer patients.

Identification of Selective SWI/SNF Dependencies in Enzalutamide-Resistant Prostate Cancer

[Communications Biology] To explore how resistance arises, scientists systematically tested all epigenetic modifiers in several models of castration-resistant and enzalutamide-resistant prostate cancer with a custom epigenetic CRISPR library.

The Oncopromoting Gene RBM6 Inhibits Prostate Tumor Cell Migration during Epithelial-to-Mesenchymal Transition

[Journal of Cellular and Molecular Medicine] To elucidate RBM6's molecular function, scratch tests, transwell migration and invasion assays were conducted, with PCR and western blot analyses verifying molecular regulatory relationships.

The Role of RhoA-ROCK Signaling in Benign Prostatic Hyperplasia: A Review

[Human Cell] Scientists summarize the potential role of RhoA/ROCK signaling in the development of benign prostatic hyperplasia.

Loss of ARID1A Accelerates Prostate Tumorigenesis with A Proliferative Collagen-Poor Phenotype through Co-Operation with AP1 Subunit CFos

[British Journal of Cancer] Using a forward-mutagenesis sleeping Beauty transposon-based screen in a probasin Cre-recombinase Pten-deficient mouse model of prostate cancer, scientists identified Arid1a loss as a driver in the development of metastatic disease.

Mitochondrial KMT9 Methylates DLAT to Control Pyruvate Dehydrogenase Activity and Prostate Cancer Growth

[Nature Communications] Researchers identified lysine methyltransferase (KMT)9 as a regulator of pyruvate dehydrogenase complex activity. KMT9 was localized in mitochondria of prostate cancer cells, but not in mitochondria of other tumor cell types.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.

spot_img