The ERG-regulated LINC00920 Promotes Prostate Cancer Cell Survival via the 14-3-3ε- FOXO Pathway

Scientists demonstrated that LINC00920 transcription was directly activated by ERG, an oncogenic transcription factor overexpressed in 50% of prostate cancers.
[Molecular Cancer Research]
Angeles, A. K., Heckmann, D., Flosdorf, N., Duensing, S., & Sultmann, H. (2020). The ERG-regulated LINC00920 promotes prostate cancer cell survival via the 14-3-3ε- FOXO pathway. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0021 Cite
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Anticancer Potential and Capsianosides Identification in Lipophilic Fraction of Sweet Pepper (Capsicum annuum L.)

The anticancer potential of the fractions was evaluated in vitro using different cancer cell lines: human colorectal carcinoma and PC-3. Fibroblast-like cells of L929 obtained from subcutaneous adipose tissue of mouse were used as normal cells.
[Molecules]
Chilczuk, B., Marciniak, B., Stochmal, A., Pecio, Ł., Kontek, R., Jackowska, I., & Materska, M. (2020). Anticancer Potential and Capsianosides Identification in Lipophilic Fraction of Sweet Pepper (Capsicum annuum L.). Molecules, 25(13), 3097. https://doi.org/10.3390/molecules25133097 Cite
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LIN28B Promotes the Development of Neuroendocrine Prostate Cancer

Using prostate adenocarcinoma and t-NEPC cell models, researchers demonstrated that LIN28B induced a stem-like gene network, neuroendocrine biomarkers, and neuroendocrine cell morphology.
[Journal of Clinical Investigation]
Lovnicki, J. M., Gan, Y., Feng, T., Li, Y., Xie, N., Ho, C.-H., … Dong, X. (2020). LIN28B promotes the development of neuroendocrine prostate cancer. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI135373 Cite
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miR-196a-mediated Downregulation of p27kip1 Protein Promotes Prostate Cancer Proliferation and Relates to Biochemical Recurrence after Radical Prostatectomy

In vivo and in vitro experiments exhibited that miR‐196a promoted prostate cancer proliferation and expedited G1/S‐phase progression through the downregulation of p27kip1 protein.
[Prostate]
Zhan, B., Huang, L., Chen, Y., Ye, W., Li, J., Chen, J., … Jiang, W. (n.d.). miR-196a-mediated downregulation of p27kip1 protein promotes prostate cancer proliferation and relates to biochemical recurrence after radical prostatectomy. The Prostate, n/a(n/a). https://doi.org/10.1002/pros.24036 Cite
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Cancer-Driven IgG Promotes the Development of Prostate Cancer though the SOX2-CIgG Pathway

Researchers assessed the effect of cancer-derived immunoglobulin G on the migratory, invasive and proliferative abilities of prostate cancer cells in vitro and in vivo.
[Prostate]
Qin, C., Sheng, Z., Huang, X., Tang, J., Liu, Y., Xu, T., & Qiu, X. (n.d.). Cancer-driven IgG promotes the development of prostate cancer though the SOX2-CIgG pathway. The Prostate, n/a(n/a). https://doi.org/10.1002/pros.24042 Cite
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RefleXion and Telix Pharmaceuticals Announce Strategic Collaboration for Treatment of High-Risk Cancers

RefleXion Medical and Telix Pharmaceuticals Limited announced a strategic collaboration to investigate the clinical utility of combining the companies’ technologies to improve treatment for high-risk or recurrent prostate and aggressive kidney cancers.
[RefleXion Medical]
Press Release

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Thioredoxin Interacting Protein (TXNIP) Acts as a Tumor Suppressor in Human Prostate Cancer

Researchers reported that the expression of thioredoxin interacting protein (TXNIP) was significantly decreased in prostate cancer and associated with clinicopathological features. Overexpression of TXNIP could significantly inhibit PC‐3 cells proliferation, migration, invasion and glucose uptake.
[Cell Biology International]
Xie, M., Xie, R., Xie, S., Wu, Y., Wang, W., Li, X., … Pan, T. (n.d.). Thioredoxin interacting protein (TXNIP) acts as a tumor suppressor in human prostate cancer. Cell Biology International, n/a(n/a). https://doi.org/10.1002/cbin.11418 Cite
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Targeting CPT1B as a Potential Therapeutic Strategy in Castration-Resistant and Enzalutamide-Resistant Prostate Cancer

The CCK-8 experiment demonstrated that CPT1B overexpression in C4-2 cells did not significantly increase the ability of enzalutamide resistance. However, overexpression of CPT1B in C4-2R cells significantly increased the enzalutamide resistance.
[Prostate]
Abudurexiti, M., Zhu, W., Wang, Y., Wang, J., Xu, W., Huang, Y., … Ye, D. (n.d.). Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer. The Prostate, n/a(n/a). https://doi.org/10.1002/pros.24027 Cite
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‘I Feel Like I Am Not Welcome’: Medical, Doctoral Students from Abroad Grapple with Uncertainty from New ICE Rules

International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
[STAT]
Press Release

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Sex Differences in SARS-CoV-2 Infection Rates and the Potential Link to Prostate Cancer

Studies of the biological interactions and molecular links may explain the reasons for the greater severity of SARS-CoV-2 in men, and specifically in the age group at risk for prostate cancer
[Communications Biology]
Chakravarty, D., Nair, S. S., Hammouda, N., Ratnani, P., Gharib, Y., Wagaskar, V., … Tewari, A. K. (2020). Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer. Communications Biology, 3(1), 1–12. https://doi.org/10.1038/s42003-020-1088-9 Cite
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Prostate Cancer-Derived Holoclones: A Novel and Effective Model for Evaluating Cancer Stemness

Researchers investigated two methods for in vitro cultivation of putative prostate cancer stem cells based on ‘high-salt agar’ and ‘monoclonal cultivation’.
[Scientific Reports]
Flynn, L., Barr, M. P., Baird, A.-M., Smyth, P., Casey, O. M., Blackshields, G., … Finn, S. P. (2020). Prostate cancer-derived holoclones: a novel and effective model for evaluating cancer stemness. Scientific Reports, 10(1), 11329. https://doi.org/10.1038/s41598-020-68187-9 Cite
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‘Disturbing and Cruel.’ Universities Blast New Visa Rule for International Students

A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
[Science]
Editorial

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