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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
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Mutant KRAS-Ma Epitranscriptome Axis Promotes Colorectal Cancer and Is a Therapeutic Target
[Advanced Science] The authors identified that KRAS mutations act as drivers mediating an aberrant epitranscriptome in colorectal cancer. They showed pharmacological blockades that could boost efficacy of KRAS inhihbitors.
Methyl-HLH-30/TFEB Orchestrates Holistic Intestinal Recuperation against Bacterial Pore-Forming Toxin Intoxication via TTC38 in Metazoans
[Autophagy] Researchers unveiled a conserved effector-triggered immunity guard system in Caenorhabditis elegans and human intestinal epithelial cells that couples pore-forming toxins damage sensing to comprehensive epithelial recuperation.
Spatial Membrane Lipid Remodelling Encodes Epithelial Lineage and State in Human Colon Cancer
[EBioMedicine] Scientists developed an integrative spatial multi-omic strategy on consecutive tissue sections from primary and intraperitoneal metastatic human colon cancer specimens, identifying four spatially organised epithelial lipid phenotypes.
Dioscin Activates Myeloid AMPK to Restore Lgr5⁺ Stem Cell Homeostasis and Promote Mucosal Repair in Ulcerative Colitis
[Pharmacological Research] Investigators showed that Dioscin, a natural steroidal saponin from Dioscoreae Rhizoma, alleviates dextran sodium sulfate-induced acute colitis and azoxymethane/dextran sodium sulfate-induced chronic colitis-associated dysplasia by reprogramming macrophage-dependent intestinal stem cell homeostasis.
Zebrafish Sox9b+ Cells Function As Intestinal Stem Cells for Epithelial Homeostasis and Regeneration
[Cell Reports] The authors identified sox9b+ cells residing within the proliferative zone of intestinal furrows as functional zebrafish intestinal stem cells that can differentiate into nearly all characterized epithelial cell lineages.
Westernized Diet Related Arachidonic Acid Metabolism Expands DNA Error-Prone Growth Factor-Dependent Colonic Quiescent Stem Cells in Adolescent Mice
[Cell Death & Disease] Researchers investigated the effects of westernized diet (WD)-induced insulin resistance (IR) on intestinal stem cells (ISCs) by in-depth phenotyping three adolescent mouse models of escalating WD-driven IR, single-cell transcriptomic data, and colonic 3D-organoid analysis.
Bcl-Xl Promotes Gastric Tumorigenesis via Apoptosis-Independent Wnt/β-Catenin Activation and PPARγ Suppression
[Cellular and Molecular Gastroenterology and Hepatology] Scientists generated mice to study gastric tumorigenesis with or without BCL2L1, a YAP target gene encoding the anti-apoptotic isoform Bcl-xL. Gastric organoids and xenografts were used to assess proliferation and downstream signaling.
Slap Restricts Oncogenic Src-Family Kinase Signaling to Maintain Colonic Epithelial Homeostasis
[Elife] The authors identified Src-like adaptor protein (SLAP), a negative regulator of receptor tyrosine kinase signaling, as a key suppressor of Src-family kinase activity in the colon.
Multi-Omics Analysis and Experiments Reveal an Association Between Polystyrene Microplastics Exposure and Colorectal Cancer Progression
[Ecotoxicology and Environmental Safety] Researchers integrated transcriptomic analysis, machine learning, public single-cell RNA sequencing datasets, and functional experiments to investigate the biological effects of polystyrene microplastics in colorectal cancer.
Dietary Bioactive Compounds Modulate Intestinal Stem Cells to Alleviate Colorectal Lesions
[Critical Reviews in Food Science and Nutrition] Scientists examine the impact of different stimulants on intestinal stem cells, focusing on their regulatory mechanisms and potential implications for colorectal lesions.
Cellular Crosstalk of Fibroblast-Myofibroblast Transition in Intestinal Homeostasis and Disease
[Biomarker Research] The authors summarize the key intercellular dialogs that regulate fibroblast-to-myofibroblast transition during the onset and progression of intestinal disorders and further analyze their regulatory mechanisms.
MaaT Pharma Receives Negative CHMP Trend Vote for MaaT013 (Xervyteg®) Following Re-Examination for its Conditional Marketing Authorization Application in Europe
[MaaT Pharma] MaaT Pharma announced that it was informed by the Committee for Medicinal Products for Human Use (CHMP) of a “negative trend” opinion as part of the re-examination procedure of its conditional Marketing Authorization Application for MaaT013 (Xervyteg®) for the treatment of acute Graft-versus-Host Disease.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
