Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Geographic and Age Variations in Mutational Processes in Colorectal Cancer

April 25, 2025

[Nature] Researchers investigated whether mutational processes contributed to geographic and age-related differences by examining 981 colorectal cancer genomes from 11 countries.

An Orally Administered Gene Editing Nanoparticle Boosts Chemo-Immunotherapy in Colorectal Cancer

April 25, 2025

[Nature Nanotechnology] Scientists developed an oral CRISPR–Cas9 delivery system based on zwitterionic and polysaccharide polymer-coated nanocomplexes that disrupted the tumor necrosis factor receptor-associated protein 1 gene in colorectal cancer.

TIPE3 Promotes Drug Resistance in Colorectal Cancer by Enhancing Autophagy via the USP19/Beclin1 Pathway

April 25, 2025

[Cell Death & Disease] Researchers investigated the function and mechanism of TIPE3 in drug resistance of colorectal cancer (CRC). TIPE3 expression in clinical samples and CRC cell lines was detected using qPCR.

Dual States of Murine Bmi1-Expressing Intestinal Stem Cells Drive Epithelial Development Utilizing Non-Canonical Wnt Signaling

April 25, 2025

[Developmental Cell] Scientists identified Bmi1⁺ cells as functional stem cells present in early murine intestinal development, prior to Lgr5-expressing intestinal stem cells (ISC)s. Lineage tracing and single-cell RNA sequencing identified that Bmi1⁺ ISCs could trace to Lgr5⁺ ISCs and other differentiated lineages.

QPS Expands Offerings With Robust Pharmacology Disease Models, Including MASH, Ulcerative Colitis, Wound Healing, and Psoriasis

April 25, 2025

[QPS (BioSpace)] QPS is pleased to announce the expansion of its pharmacology disease models portfolio to include highly relevant models for metabolic dysfunction-associated steatohepatitis (MASH), ulcerative colitis, wound healing, and psoriasis.

TREMFYA® (Guselkumab) Receives European Commission Approval for Adults with Moderately to Severely Active Ulcerative Colitis, Strengthening Johnson & Johnson’s Leadership in Inflammatory Bowel Disease

April 25, 2025

[Johnson & Johnson] Johnson & Johnson announced that the European Commission has approved a Marketing Authorisation for TREMFYA^® for the treatment of adult patients with moderately to severely active ulcerative colitis who had an inadequate response, lost response, or were intolerant to either conventional therapy or a biologic treatment.

Promising Immunotherapeutic Treatments for Colon Cancer

April 25, 2025

[Medical Oncology] The authors investigate immunotherapeutic interventions for colon cancer, which include immune checkpoint inhibitors, oncolytic virotherapy, cancer vaccines, cytokine therapy, and CAR-T.

Neutrophil-Derived Serine Proteases Induce FOXA2-Mediated Autophagy Dysfunction and Exacerbate Colitis-Associated Carcinogenesis via Protease Activated Receptor 2

April 23, 2025

[Autophagy] Researchers showed that F2rl1/Par2 deficiency aggravated azoxymethane-dextran sulfate sodium-induced colitis-associated colorectal cancer based on tumor number and burden, promoted autophagy dysfunction characterized by SQSTM1/p62 accumulation and autophagosome-lysosome fusion inhibition in intestinal epithelial cells.

Nucleic Acid-Functionalized Gold Nanorods Modulate Inflammation and Dysregulated Intestinal Barriers for Treatment of Ulcerative Colitis

April 23, 2025

[Biomaterials Research] The authors presented nucleic acid-functionalized gold nanorods, a biocompatible nanomaterial designed for the oral treatment of dextran sulfate sodium-induced colitis.

Dual Modulation of Cytotoxic and Checkpoint Receptors Tunes the Efficacy of Adoptive Delta One T Cell Therapy against Colorectal Cancer

April 21, 2025

[Nature Cancer] Investigators demonstrated the capacity of Delta One T cells to target colorectal cancer (CRC) cell lines and patient-derived specimens and organoids in vitro and to control tumor growth in an orthotopic xenograft model of CRC.

Phospholipase D6 Activates Wnt/β-catenin Signaling through Mitochondrial Metabolic Reprogramming to Promote Tumorigenesis in Colorectal Cancer

April 21, 2025

[Experimental & Molecular Medicine] Scientists found that phospholipase D6 (PLD6) was highly expressed in colorectal cancer (CRC) and positively correlated with poor prognosis. PLD6 depletion suppressed the oncogenic properties of CRC cells and impaired mitochondrial respiration, leading to reduced mitochondrial length and reactive oxygen species.

Male-Specific Lethal 1 (MSL1) Promotes Erastin-Induced Ferroptosis in Colon Cancer Cells by Regulating the KCTD12-SLC7A11 Axis

April 15, 2025

[Cell Death & Disease] Researchers provided evidence of a negative regulatory relationship between MSL1 and KCTD12 through biochemical assays and knockdown/overexpression studies.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.