Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Deep Crypt Secretory Cells Shape Region-Specific Mucin Glycosylation Patterns in the Mouse Colon

July 16, 2025

[PLOS One] Using fluorescence-based immunohistological analyses of the colon from experimental mice, scientists demonstrated that along with contribution of goblet cells, mucin glycosylation involves deep crypt secretory cells, a specialized mucin-producing cell population in the colon.

Regulation of Revival Stem Cell Differentiation by CREPT/RPRD1B during Intestinal Regeneration

July 16, 2025

[Cell & Bioscience] Researchers demonstrated that CREPT/RPRD1B, a protein highly expressed in tumors and essential for crypt-base columnar cell maintenance, was required for revival stem cell differentiation during intestinal regeneration.

Decitabine Regulates the Resistance of HCC to Sorafenib through Demethylation

July 8, 2025

[Clinical Epigenetics] Scientists evaluated the efficacy of sorafenib in combination with the DNA methylation inhibitor decitabine for the treatment of HCC.

Positional BMP Signaling Orchestrates Villus Length in the Small Intestine

July 7, 2025

[Nature Communications] Researchers showed that BMP signaling regulates the survival of the small intestine epithelial cells by inhibiting integrin expression and thereby inducing cell apoptosis.

Lipoic Acid Functions in Paneth Cells to Prevent Human Intestinal Stem Cell Aging

July 4, 2025

[Nature Communications] Scientists discerned that the effect of α-lipoic acid on mitigating intestinal stem cell (ISC) aging is contingent upon the presence of Paneth cells.

MTCH2 Deficiency Promotes E2F4/TFRC-Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

July 4, 2025

[Advanced Science] Investigators revealed the mechanism of mitochondrial carrier homolog 2 (MTCH2) deficiency-induced ferroptosis to inhibit the progression of colorectal cancer.

EZH2 Loss Promotes Gastric Squamous Cell Carcinoma

July 4, 2025

[Nature Communications] Researchers performed genomics analyses of twenty gastric squamous cell carcinoma samples and found that epigenetic regulation genes are among the most frequently mutated genes, including enhancer of zeste homolog 2 (EZH2).

CytoDyn Announces First Patient Dosed in Phase II Oncology Trial in Colorectal Cancer

July 4, 2025

[CytoDyn, Inc.] CytoDyn, Inc. announced that the first patient has been dosed in the Company’s clinical trial evaluating the efficacy of leronlimab in patients with relapsed/refractory microsatellite stable colorectal cancer.

STK3 Is a Transcriptional Target of YAP1 and a Hub Component in the Crosstalk between Hippo and Wnt Signaling Pathways during Gastric Carcinogenesis

July 4, 2025

[Molecular Cancer] The authors explored the upregulation pattern and molecular mechanisms of serine/threonine kinase 3 (STK3) in advancing gastric cancer progression.

A Patient-Derived Organoid Model Captures Fetal-Like Plasticity in Colorectal Cancer

July 4, 2025

[Cell Research] Scientists established a chemically defined patient-derived organoid system that enables long-term expansion of colorectal cancer cells while preserving fetal-like features associated with phenotypic plasticity.

Celiac Disease and the Intestinal Barrier: Mechanisms of Disruption and Strategies for Restoration

July 2, 2025

[Gut] The authors explore the evidence for increased permeability in coeliac disease and the underlying mechanisms, including the roles of zonulin, inflammatory cytokines, microbial alterations, and immune responses to gliadin peptides.

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes

June 24, 2025

[New England Journal of Medicine] In this Phase III, double-blind, placebo-controlled trial, we randomly assigned participants in a 1:1:1:1 ratio to receive orforglipron at one of three doses or placebo once daily for 40 weeks.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.