Neutrophil Extracellular Traps Impair Intestinal Barrier Functions in Sepsis by Regulating TLR9-Mediated Endoplasmic Reticulum Stress Pathway

Neutrophil extracellular traps treatment induced intestinal epithelial monolayer barrier disruption and endoplasmic reticulum (ER) stress activation in a dose-dependent manner in vitro, and ER stress inhibition markedly attenuated intestinal apoptosis and tight junction injury.
[Cell Death & Disease]
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BCL-XL Is Crucial for Progression through the Adenoma-to-Carcinoma Sequence of Colorectal Cancer

By targeting antiapoptotic proteins with specific BH3 mimetics in organoid models of colorectal cancer progression, scientists found that BCL-2 was essential only during instestinal stem cell transformation while MCL1 inhibition did not affect adenoma outgrowth.
[Cell Death & Differentiation]
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PRDX2 Promotes the Proliferation of Colorectal Cancer Cells by Increasing the Ubiquitinated Degradation of p53

The authors investigated the mechanisms by which PRDX2 promoted the proliferation of colorectal cancer, and found that the oncogenic property of PRDX2 may have been attributed to its regulation of the RPL4-MDM2-p53 pathway, leading to p53 ubiquitinated degradation.
[Cell Death & Disease]
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BeiGene Announces Acceptance of a Supplemental Biologics License Application in China for Tislelizumab in Microsatellite Instability-High (MSI-H) or Mismatch Repair-Deficient (dMMR) Solid Tumors

BeiGene, Ltd. announced that the Center for Drug Evaluation of the China National Medical Products Administration has accepted a supplemental Biologics License Application for anti-PD-1 antibody tislelizumab for the treatment of patients with previously treated, locally advanced unresectable or metastatic microsatellite instability-high or mismatch repair-deficient solid tumors.
[BeiGene, Ltd.]
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Multilevel Regulation of Wnt Signaling by Zic2 in Colon Cancer Due to Mutation of β-Catenin

Researchers demonstrated that Zic2 was highly expressed in colon cancer tissues and correlated with poor survival. Knockdown of Zic2 inhibited colon cancer cell growth, arrested the cell cycle transition from G0/G1 to S phase, and suppressed tumor sphere formation in vitro.
[Cell Death & Disease]
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miR-802 Regulates Paneth Cell Function and Enterocyte Differentiation in the Mouse Small Intestine

Investigators showed that the intestine-enriched miR-802 was a central regulator of intestinal epithelial cell proliferation, Paneth cell function, and enterocyte differentiation.
[Nature Communications]
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LncRNA Bmp1 Promotes the Healing of Intestinal Mucosal Lesions via the miR-128-3p/PHF6/PI3K/AKT Pathway

The authors investigated the mechanisms of action of long non-coding RNA Bmp1 on damaged intestinal mucosa. They found that Bmp1 was increased in damaged intestinal mucosal tissue and Bmp1 overexpression was able to alleviate intestinal mucosal injury.
[Cell Death & Disease]
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Assessment of Copy Number in Protooncogenes Are Predictive of Poor Survival in Advanced Gastric Cancer

Researchers characterized the clinicopathological features, including prognosis, of gastric carcinomas with copy number gains in multiple protooncogenes.
[Scientific Reports]
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Genetic and Commensal Induction of IL-18 Drive Intestinal Epithelial MHCII via IFNγ

Scientists linked intestinal dysbiosis, systemic inflammation, and inflammasome activity to intestinal epithelial cells major histocompatibility complex class II upregulation via an intestinal serum Interleukin-18-interferon gamma axis.
[Mucosal Immunology]
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Oncogenic BRAF, Unrestrained by TGFβ-Receptor Signaling, Drives Right-Sided Colonic Tumorigenesis

The proximal colonic tumors that developed in a mouse model of right-sided colon cancer exhibited a fetal-like progenitor phenotype (Ly6a/Sca1+) and lacked expression of Lgr5 and its associated intestinal stem cell signature.
[Nature Communications]
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Organoids and Organs-on-Chips: Insights into Human Gut-Microbe Interactions

The authors review recent advances in the co-culture of microbes with intestinal and colonic epithelia, comparing the rapidly developing fields of organoids and organs-on-chips with other standard models.
[Cell Host & Microbe]
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