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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
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EIF4B Ser93 Phosphorylation by ERK2 Promotes Epithelial-Mesenchymal Transition to Drive Colorectal Cancer Metastasis
[Cell Death & Disease] Investigators identified significant alterations in protein phosphorylation associated with CRC through tandem mass tag label-based phosphoproteomic analysis.
MRM Health Secures FDA IND Clearance to Launch its Phase IIb Trial of MH002 in Mild-to-Moderate Ulcerative Colitis
[MRM Health] MRM Health NV announced that the US FDA has granted clearance of its Investigational New Drug (IND) application for its lead program MH002. This enables the initiation of the STARFISH-ulcerative colitis Phase IIb clinical trial in patients with mild-to-moderate ulcerative colitis
CBX4 Drives Gastric Cancer Progression by Activating β-Catenin Signaling
[Oncology Research] Chromobox 4 (CBX4) expression was assessed in gastric cancer (GC) tissues vs. adjacent non-cancerous tissues and in GC cell lines vs. normal gastric mucosal epithelial cells.
Gastric Cancer
[JAMA] Approximately 30 300 new cases of gastric cancer are diagnosed annually in the United States. Localized gastric cancer is treated with gastrectomy, and locally advanced disease is treated with surgery and chemoimmunotherapy.
Obesity Impairs Gut Repair via AFABP-Mediated Iron Overload in Intestinal Stem Cells
[Nature Metabolism] The authors showed that adipocyte fatty acid-binding protein (AFABP), an adipokine involved in fatty acid transport, impedes intestinal repair by disrupting iron homeostasis in intestinal stem cells.
ALKBH5 Enhances Cadmium-Induced Stemness Enrichment and Proliferation of Colon Cancer Cells via M6a-Dependent Regulation of AXIN2 and Activation of Wnt/β-catenin Signaling
[Chemico-Biological Interactions] Scientists investigated the long-term effects of cadmium on stemness enrichment and proliferation in colon cancer cells, and identified the key signaling pathways involved.
Integrated Microfluidic Platform for High-Throughput Generation of Intestinal Organoids in Hydrogel Droplets
[Advanced Science] Researchers presented an integrated microfluidic platform that addresses these limitations by enabling high-throughput generation of uniform hydrogel microparticles embedded with primary-derived human adult intestinal stem cells.
Small Nucleolar RNA Snord17 Promotes Self-Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation
[Advanced Science] The authors identified a small nucleolar RNA Snord17 that is highly expressed in intestinal stem cells (ISCs). Snord17 knockout abrogates stemness of ISCs and impairs epithelial regeneration.
USP11 Promotes Colorectal Cancer Progression by Stabilizing EGFR and TRAF6: A Potential Therapeutic Target in EGFR- and TLR-Driven Tumorigenesis
[Cell Death & Disease] Researchers investigated the role of ubiquitin-specific protease (USP) 11 in colorectal cancer (CRC) pathogenesis. RNA-seq analysis of tumor and matched normal tissues from 35 CRC patients identified USP11 as significantly overexpressed in tumor samples.
YTHDF1 Targets the Chemotherapy Response by Suppressing NOTCH1-Induced Stemness in Colorectal Cancer
[Signal Transduction and Targeted Therapy] Investigators found that the N6-methyladenosine reader YT521-B homologous domain family, member 1 (YTHDF1), promotes colorectal cancer stemness, tumorigenesis, and chemotherapy resistance.
AQP5: A Functional Gastric Cancer Stem Cell Marker in Mouse and Human Tumors
[Science] Scientists reported that the surface marker AQP5 enriches for gastric CSCs in mouse and human tumors arising from the distal pyloric stomach.
Epithelial WNT Secretion Drives Niche Escape of Developing Gastric Cancer
[Molecular Cancer] Researchers analyzed mouse gastric organoids harboring oncogenic KRASG12D with or without RNF43/ZNRF3 or CDH1/TP53 mutations, along with corresponding in vivo mouse models.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
