LncRNA MIR17HG Promotes Colorectal Cancer Liver Metastasis by Mediating a Glycolysis-Associated Positive Feedback Circuit

MIR17HG promoted glycolysis in colorectal cancer (CRC) cells and enhanced their invasion and liver metastasis in vitro and in vivo. Mechanistically, MIR17HG functioned as a ceRNA to regulate HK1 expression by sponging miR-138-5p, resulting in glycolysis in CRC cells and leading to their invasion and liver metastasis.
[Oncogene]
Full Article
Bookmark

No account yet? Register

0
Share

The HSF1/miR-135b-5p Axis Induces Protective Autophagy to Promote Oxaliplatin Resistance through the MUL1/ULK1 Pathway in Colorectal Cancer

Investigators showed the differentially expressed miRNAs in oxaliplatin-sensitive and oxaliplatin-resistant colorectal cancer cells through miRNA microarray technology and found that miR-135b-5p was significantly increased in oxaliplatin-resistant cells.
[Oncogene]
Abstract
Bookmark

No account yet? Register

0
Share

Genome Researchers Question Security Provisions in New US Senate Bill

Buried in a bill approved by the US Senate to help the United States compete with China is language that is drawing fire from human genome researchers. It would require the NIH to develop new security protocols aimed at preventing the misuse of US-funded genomic data by China and other nations.
[Science]
Editorial
Bookmark

No account yet? Register

0
Share

Asporin Represses Gastric Cancer Apoptosis via Activating LEF1-Mediated Gene Transcription Independent of β-Catenin

Researchers reported that asporin (ASPN) was upregulated in different stages of gastric cancer (GC), and associated with a poor prognosis, and found that ASPN markedly inhibited GC cell apoptosis and promoted cell growth in vitro and in vivo.
[Oncogene]
Abstract
Bookmark

No account yet? Register

0
Share

Acrolein Contributes to Human Colorectal Tumorigenesis through the Activation of RAS-MAPK Pathway

Scientists found that acrolein induced oncogenic transformation, including faster cell cycling, proliferation, sphere formation and cell migration, in fibroblast cells, and acrolein-induced DNA damages were higher in colorectal cancer (CRC) tumor tissues than in normal epithelial cells in CRC patients.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

0
Share

MYH9-Dependent Polarization of ATG9B Promotes Colorectal Cancer Metastasis by Accelerating Focal Adhesion Assembly

Researchers identified autophagy-related protein 9B (ATG9B) as a key potential target gene for colorectal cancer (CRC) metastasis, and found that ATG9B promoted CRC invasion mainly through autophagy-independent manner.
[Cell Death & Differentiation]
Full Article
Bookmark

No account yet? Register

0
Share

Gasdermin-E-Mediated Pyroptosis Participates in the Pathogenesis of Crohn’s Disease by Promoting Intestinal Inflammation

Investigators showed that the pyroptosis-inducing fragment GSDME N-terminal was detected in the inflamed colonic mucosa but not in the uninflamed mucosa of patients with Crohn’s disease (CD), suggesting that GSDME-mediated pyroptosis may be correlated with intestinal mucosal inflammation in CD.
[Cell Reports]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

IL-6 Regulates Autophagy and Chemotherapy Resistance by Promoting BECN1 Phosphorylation

The authors demonstrated that IL-6 activated autophagy through the IL-6/JAK2/BECN1 pathway and promoted chemotherapy resistance in colorectal cancer.
[Nature Communications]
Full Article
Bookmark

No account yet? Register

0
Share

The Phosphatase PRL-3 Affects Intestinal Homeostasis by Altering the Crypt Cell Composition

Researchers employed a doxycycline-inducible phosphatase of regenerating liver-3 (PRL-3) mouse strain to show that aberrant PRL-3 expression within a non-cancerous background led to the death of Lgr5+ intestinal stem cells and to Paneth cell expansion.
[Journal of Molecular Medicine]
Full Article
Bookmark

No account yet? Register

0
Share

Phosphatidylserine Externalized on the Colonic Capillaries as a Novel Pharmacological Target for IBD Therapy

Investigators showed that externalized phosphatidylserine (PS) was observed on the surface of colonic capillaries. Annexin A5 with high affinity for PS had a good targeting to the colon and effectively alleviated experimental colitis.
[Signal Transduction and Targeted Therapy]
Full Article
Bookmark

No account yet? Register

0
Share

14-3-3σ Functions as an Intestinal Tumor Suppressor

The authors determined that 14-3-3σ expression was significantly downregulated in primary human colorectal cancer when compared with adjacent normal colonic tissue in patient samples. Downregulation of 14-3-3σ in primary colorectal cancers was significantly associated with p53 mutation, increasing tumor stage, distant metastasis, and poor patient survival.
[Cancer Research]
AbstractPress Release
Bookmark

No account yet? Register

0
Share
Share