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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
Lipoic Acid Functions in Paneth Cells to Prevent Human Intestinal Stem Cell Aging
[Nature Communications] Scientists discerned that the effect of α-lipoic acid on mitigating intestinal stem cell (ISC) aging is contingent upon the presence of Paneth cells.
MTCH2 Deficiency Promotes E2F4/TFRC-Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib
[Advanced Science] Investigators revealed the mechanism of mitochondrial carrier homolog 2 (MTCH2) deficiency-induced ferroptosis to inhibit the progression of colorectal cancer.
EZH2 Loss Promotes Gastric Squamous Cell Carcinoma
[Nature Communications] Researchers performed genomics analyses of twenty gastric squamous cell carcinoma samples and found that epigenetic regulation genes are among the most frequently mutated genes, including enhancer of zeste homolog 2 (EZH2).
CytoDyn Announces First Patient Dosed in Phase II Oncology Trial in Colorectal Cancer
[CytoDyn, Inc.] CytoDyn, Inc. announced that the first patient has been dosed in the Company’s clinical trial evaluating the efficacy of leronlimab in patients with relapsed/refractory microsatellite stable colorectal cancer.
STK3 Is a Transcriptional Target of YAP1 and a Hub Component in the Crosstalk between Hippo and Wnt Signaling Pathways during Gastric Carcinogenesis
[Molecular Cancer] The authors explored the upregulation pattern and molecular mechanisms of serine/threonine kinase 3 (STK3) in advancing gastric cancer progression.
A Patient-Derived Organoid Model Captures Fetal-Like Plasticity in Colorectal Cancer
[Cell Research] Scientists established a chemically defined patient-derived organoid system that enables long-term expansion of colorectal cancer cells while preserving fetal-like features associated with phenotypic plasticity.
Celiac Disease and the Intestinal Barrier: Mechanisms of Disruption and Strategies for Restoration
[Gut] The authors explore the evidence for increased permeability in coeliac disease and the underlying mechanisms, including the roles of zonulin, inflammatory cytokines, microbial alterations, and immune responses to gliadin peptides.
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
[New England Journal of Medicine] In this Phase III, double-blind, placebo-controlled trial, we randomly assigned participants in a 1:1:1:1 ratio to receive orforglipron at one of three doses or placebo once daily for 40 weeks.
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
[New England Journal of Medicine] Investigators conducted a Phase I–II study of zimislecel in persons with type 1 diabetes. In part A, participants received a half dose of zimislecel as a single infusion into the portal vein, with an option for a second half dose within two years. In parts B and C, participants received a full dose of zimislecel as a single infusion.
Glucose Metabolism and Regulation in Establishing Human Stem Cell-Derived β Cell Maturation
[Cell Reports] Scientists summarize the updated understanding of glucose metabolism in mature β and stem cell-derived β (SC-β) cells, highlighting a potential metabolic defect underlying SC-β immaturity.
Amplia Receives US Ethics Clearance For Pancreatic Cancer Trial
[Amplia Therapeutics] Amplia has received US ethics approval to initiate a Phase II clinical trial of narmafotinib in combination with FOLFIRINOX chemotherapy for advanced pancreatic cancer patients.
BRAFV600E Maintains the CpG Island Methylator Phenotype and DNA Methylation of PRC2 Target Genes in Colon Cancer
[iScience] Scientists show that BRAFV600E maintains aberrant DNA and histone methylation patterns in advanced colon cancer, likely preserving the transformed phenotype.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
