Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

HKBU Develops Chinese Medicine for Ulcerative Colitis Approved by National Medical Products Administration for Clinical Trial

September 6, 2024

[Hong Kong Baptist University (PR Newswire)] The Centre for Chinese Herbal Medicine Drug Development (CDD) at Hong Kong Baptist University (HKBU) has achieved a significant milestone in developing a novel Chinese herbal formulation for ulcerative colitis remission maintenance. Following a submission of Investigational New Drug application for CDD-2103 to the National Medical Products Administration, CDD has received its authorization for clinical trial.

Debbie’s Dream Foundation Celebrates Groundbreaking Research by Dr. Valerie O’Brien on H. pylori and Gastric Cancer

September 6, 2024

[Debbie's Dream Foundation (Longview News-Journal)] Debbie's Dream Foundation: Curing Stomach Cancer proudly recognizes Dr. Valerie O'Brien for her groundbreaking research into the link between Helicobacter pylori and gastric cancer.

Diagnosis and Management of Clostridioides difficile in Inflammatory Bowel Disease

September 5, 2024

[American Journal of Gastroenterology] The authors provide a comprehensive overview of the diagnosis, treatment, and prevention of Clostridioides difficile infection in IBD patients.

Inflammation-Induced Epigenetic Imprinting Regulates Intestinal Stem Cells

September 5, 2024

[Cell Stem Cell] Utilizing single-cell transcriptomics, as well as organoid, metabolic, epigenomic, and in vivo models, scientists reported that Lgr5+ intestinal stem cells underwent metabolic changes that led to the accumulation of succinate, which reprogrammed their epigenome.

Dual Function of PHF16 in Reinstating Homeostasis of Murine Intestinal Epithelium after Crypt Regeneration

September 5, 2024

[Developmental Cell] Researchers reported that the epigenetic regulator plant homology domain (PHD) finger protein 16 (PHF16) restored homeostasis of the intestinal epithelium after initial damage-induced repair.

Construction of Multilayered Small Intestine-Like Tissue by Reproducing Interstitial Flow

September 5, 2024

[Cell Stem Cell] Investigators constructed an in vivo-like multilayered small intestinal tissue by incorporating interstitial flow into the system and, in turn, developed the micro-small intestine system by differentiating definitive endoderm and mesoderm cells from human pluripotent stem cells simultaneously on a microfluidic device capable of replicating interstitial flow.

Melatonin Mitigates Chemotherapy-Induced Small Intestinal Atrophy in Rats and Reduces Cytotoxicity in Murine Intestinal Organoids

September 5, 2024

[PLOS One] The authors elucidated the potential of melatonin and misoprostol to reduce 5-fluorouracil-induced small intestinal mucositis. Morphological and cellular changes in the jejunum, along with colonic faecal water content were quantified in rats as markers for chemotherapy-induced mucositis.

Hyperglycemic Environments Directly Compromise Intestinal Epithelial Barrier Function in an Organoid Model and Hyaluronan (∼35 kDa) Protects via a Layilin Dependent Mechanism

September 5, 2024

[Matrix Biology] Intestinal organoids derived from mouse colon were grown in normal glucose media (5 mM) or high glucose media (25 mM) to study the impact of hyperglycemic stress on the intestinal barrier.

Targeting POLRMT by IMT1 Inhibits Colorectal Cancer Cell Growth

September 4, 2024

[Cell Death & Disease] Researchers investigated the potential anti-colorectal cancer (CRC) activity of IMT1, a novel specific inhibitor of mitochondrial RNA polymerase (POLRMT). IMT1 inhibited colony formation, cell viability, proliferation, cell cycle progression, and migration in both primary and immortalized CRC cells.

Intensified versus Standard Dose Infliximab Induction Therapy for Steroid-Refractory Acute Severe Ulcerative Colitis (PREDICT-UC): An Open-Label, Multicentre, Randomised Controlled Trial

September 4, 2024

[Lancet Gastroenterology and Hepatology] In this open-label, multicenter, randomized controlled trial, patients aged 18 years or older from 13 Australian tertiary hospitals with intravenous steroid-refractory acute severe ulcerative colitis were randomly assigned to receive a first dose of ten mg/kg infliximab or five mg/kg infliximab.

B4GALT1-Dependent Galectin-8 Binding with TGF-β Receptor Suppresses Colorectal Cancer Progression and Metastasis

September 4, 2024

[Cell Death & Disease] Scientists investigated whether the cooperation between tumor-associated N-glycosylation and a glycan-binding protein modulated the TGF-β-driven signaling and metastasis of colorectal cancer.

Targeting m7G-Enriched circKDM1A Prevents Colorectal Cancer Progression

September 3, 2024

[Molecular Cancer] Researchers uncovered an essential physiological function and mechanism of METTL1-mediated m7G modification in the regulation of circRNA stability and cancer progression.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.