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Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
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$1 Million Grant Fuels Research on Precise Cancer Radiation
Dermal Cell NewsHematopoiesis NewsHepatic Cell NewsIntestinal Cell NewsMammary Cell NewsNewslettersPancreatic Cell NewsProstate Cell NewsPulmonary Cell News
[University of Missouri School of Medicine] Researchers from the University of Missouri School of Medicine recently received a $1 million grant from the National Institutes of Health to study the latest technology in cancer research.
A Self-Amplifying Nerve-Fibroblast Circuit Drives Colorectal Cancer Progression
[Cancer Cell] The authors showed that in colorectal cancer, cholinergic stimulation induces CHRM3/Gq-dependent NTN1 secretion from cancer-associated fibroblasts, which in turn enhances intratumor cholinergic innervation.
Iron-Addicted Colorectal Cancers Exploit Heme-Complex II Axis to Resist Oxidative Cell Death
[Cell Metabolism] Researchers showed that the canonical anti-ferroptosis response mediated by GPX4 and SLC7A11 is dispensable for colorectal cancer growth and progression in both sporadic and colitis-associated cancer models.
Mitochondrial Metabolism Determines Chemotherapy Sensitivity in Colorectal Cancer
[Nature Metabolism] Scientists demonstrated in a range of colorectal cancer models that 5-fluorouracil treatment promotes mitochondrial biogenesis and increases mitochondrial function in surviving cells.
Obesity-Driven Microbial GABA Depletion Promotes Metabolic Rewiring and Colorectal Cancer Progression
[Nature Communications] Investigators showed that a high-fat diet and fecal microbiota from patients with obesity-associated colorectal cancer deplete the GABA-producing commensal Bacteroides ovatus, resulting in reduced luminal GABA and accelerated tumorigenesis.
RADX Protects against Intestinal Inflammation by Restraining IFI16-Mediated Innate Immunity
[EMBO Molecular Medicine] Researchers identified RADX, a structural antagonist to RAD51 and a key regulator of replication fork stability, as a critical suppressor of intestinal inflammation by limiting innate immune sensing of replication-associated DNA damage.
TBX1 Suppresses Colorectal Cancer Cells via PPP2R2B-Mediated Inhibition of MAPK/ERK and PI3K/AKT Pathways
[Cellular Signalling] Scientists assessed the impact of TBX1 on the proliferation and colony-forming capacity of colorectal cancer cells, and carried out in vitro functional investigations.
MFN2 Inhibits Colorectal Cancer Tumorigenesis by Regulating Glycolysis through TRIM21-Mediated PFKP Stability
[Molecular Immunology] Investigators founds that the overexpression of Mitofusin-2 (MFN2) suppressed colorectal cancer cell glycolysis and tumor growth by enhancing TRIM21-mediated degradation of PFKP.
Deciphering the Colorectal Tumor Microenvironment: Interactions and Targets for Effective Therapy
[Biochemical Pharmacology] The authors highlight how interactions within the colorectal tumor microenvironment drive metastasis, immune evasion, and therapy resistance, revealing new opportunities for combination cancer therapies.
Dispatch Bio Announces First Patient Dosed in Phase I Study of DISP-10, a Novel Investigational Immunotherapy, in Advanced Gastrointestinal (GI) Cancers
[Dispatch Bio] Dispatch Bio announced the first participant has been dosed in a Phase I clinical trial evaluating the safety and efficacy of DISP-10 in adult participants with advanced gastrointestinal (GI) cancers,
Oncogenic snoRNA SNORD78 Fuels Colorectal Cancer by Protecting the m6a Reader IMP2 to Enhance Phospholipid Metabolism
[Proceedings of the National Academy of Sciences of the United States of America] The authors systematically deciphered the precise interaction mechanism between SNORD78 and the m6A reader IMP2 in colorectal cancer.
DCAF13: A Positive Regulator of Colon Cancer Cell Proliferation via the AMER2/ Wnt/β-Catenin Pathway
[NPJ Precision Oncology] As one of the Cullin RING Ligase 4 adapters, DNA damage-binding protein 1 - and CUL4 correlation factor 13 (DCAF13) appeared strongly expressed in different tumors. Scientists' findings confirm enhanced expression of DCAF13 in tissues of colorectal cance origin and related cell.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
