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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
Phase II Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis
[New England Journal of Medicine] In this short-term trial, tulisokibart was more effective than placebo in inducing clinical remission in patients with moderately to severely active ulcerative colitis.
p21 Regulates Wnt-Notch Balance via DREAM/MMB/RB-E2F1 and Maintains Intestinal Stem Cell Homeostasis
[Cell Death Discovery] Disruption in Wnt-Notch signaling was accompanied by the loss of intestinal stem cell compartment, increase in Bmi1 positive cells, loss of Olfm4/Lgr5 positive cells, and reduced secretory Paneth cells and goblet cells in the intestinal crypts of p21TKO mice.
Theranostic GPA33-Pretargeted Radioimmunotherapy of Human Colorectal Carcinoma with a Bivalent 177Lu-Labeled Radiohapten
[Journal of Nuclear Medicine] Investigators developed a bivalent DOTA-radiohapten, [177Lu]Lu-Gemini, that showed improved radiopharmacology for DOTA-based pretargeted radioimmunotherapy application.
Dietary and Metabolic Effects on Intestinal Stem Cells in Health and Disease
[Nature Reviews Gastroenterology & Hepatology] Investigators discuss how different diets and metabolic changes influence intestinal stem cells in homeostatic and pathological conditions, as well as tumorigenesis.
A Phase 1 Trial of Trebananib, an Angiopoietin 1 and 2 Neutralizing Peptibody, Combined with Pembrolizumab in Patients with Advanced Ovarian and Colorectal Cancer
[Cancer Immunology Research] Investigators performed a Phase I dose-escalation study of pembrolizumab and the angiopoietin 1/2 inhibitor trebananib. This multicenter trial enrolled patients with metastatic ovarian cancer or microsatellite stable colorectal cancer.
Selenium Attenuates Radiation Colitis by Regulating cGAS-STING Signaling
[Advanced Science] Selenium was protective against radiation colitis through inhibiting X-ray-induced apoptosis, cell cycle arrest, and inflammation with the involvement of balancing the generation of reactive oxygen species after the irradiation.
Tuft Cells in the Intestine, Immunity, and Beyond
[Nature Reviews Gastroenterology & Hepatology] The authors provide an overview of intestinal tuft cells, providing insights into their development, signaling, and interaction modules in immunity and other states.
Confined Copper Depletion via a Hydrogel Platform for Reversing Dabrafenib/Cetuximab Resistance in BRAFV600E-Mutant Colorectal Cancer
[Journal of Controlled Release] Scientists developed a hydrogel platform for confined copper depletion in BRAFV600E-mutant colorectal cancer cells, which effectively reversed dabrafenib/cetuximab resistance and enhancing therapeutic efficiency.
Targeting the Sphingosine-1-Phosphate Pathway: New Opportunities in Inflammatory Bowel Disease Management
[Drugs] Scientists discuss the role of the sphingosine-1-phosphate (S1P)/S1P receptor axis in the pathogenesis of IBD and discuss efficacy and safety data from clinical trials and real-world reports on the two S1PR modulators, ozanimod and etrasimod, that are currently approved for IBD treatment.
DKK1 as a Chemoresistant Protein Modulates Oxaliplatin Responses in Colorectal Cancer
[Oncogenesis] By utilizing the leucine zipper protein, investigators disrupted dickkopf-1 (DKK1) signaling, enhancing oxaliplatin sensitivity in oxaliplatin-resistant colorectal cancer cells and xenograft tumors.
Neoadjuvant Immunotherapy for dMMR and pMMR Colorectal Cancers: Therapeutic Strategies and Putative Biomarkers of Response
[Nature Reviews Clinical Oncology] The authors describe the current and emerging clinical evidence supporting the use of neoadjuvant immune-checkpoint inhibitors in patients with DNA mismatch repair deficiency and proficient DNA mismatch repair colorectal cancer, and the potential advantages of such an approach.
Disorders of Gastric Motility
[Lancet Gastroenterology and Hepatology] Scientists provide an overview of gastroparesis and functional dyspepsia from the perspective of gastric motility, discussing what is distinct and what is shared between these disorders.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
