Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Polysaccharide-Based Drug Delivery Targeted Approach for Colon Cancer Treatment: A Comprehensive Review

January 17, 2025

The authors underscore the need for continued research on polysaccharide-based colon-targeted drug delivery systems for colon cancer treatment, offering a path toward more effective,...

DNA Replication Stress Underpins the Vulnerability to Oxidative Phosphorylation Inhibition in Colorectal Cancer

January 14, 2025

Scientists showed that inhibiting oxidative phosphorylation similarly suppresses the proliferation and tumorigenicity of glycolytically competent colorectal cancer (CRC) cells in vitro and in patient-derived...

Transcription Factor FOXD1 and miRNA-204-5p Play a Major Role in B4GALNT2 Downregulation in Colon Cancer

January 14, 2025

FOXD1 knock down in the non-β1,4-N-acetylgalactosaminyltransferase 2 (B4GALNT2) expresser cell line SW948 stimulated B4GALNT2. Thus, FOXD1 and miR-204-5p emerged as crucial new player of...

GNG2 Inhibits Brain Metastases from Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway

January 14, 2025

Researchers suggested that GNG2 contributed to tumor suppression in colorectal cancer (CRC), particularly in preventing brain metastasis, and could serve as a promising biomarker...

Trastuzumab plus Pertuzumab Versus Cetuximab plus Irinotecan in Patients with RAS/BRAF Wild-Type, HER2-Positive, Metastatic Colorectal Cancer (S1613): A Randomized Phase II Trial

January 7, 2025

[Journal of Clinical Oncology] Investigators conducted a randomized Phase II trial to evaluate efficacy and safety of dual-HER2 inhibition against standard-of-care anti-EGFR antibody–based therapy as second/third-line treatment in HER2-positive metastatic colorectal cancer.

Neoadjuvant Chemoradiation With or Without PD-1 Blockade in Locally Advanced Rectal Cancer: A Randomized Phase II Trial

January 7, 2025

[Nature Medicine] Scientists evaluated the efficacy and safety of the radiation–immune checkpoint inhibitor combination in patients with locally advanced rectal cancer in a Phase II, randomized trial conducted in eight major colorectal cancer centers in Beijing.

STAT1 Regulates Immune-Mediated Intestinal Stem Cell Proliferation and Epithelial Regeneration

January 6, 2025

[Nature Communications] To assess impacts of T cell-driven injury on distinct epithelial constituents, scientists performed single cell RNA sequencing on intestinal crypts following experimental bone marrow transplantation.

China’s National Medical Products Administration (NMPA) Approves VYLOYTM (zolbetuximab) for First-Line Treatment of Advanced Gastric or Gastroesophageal Junction Adenocarcinoma

January 6, 2025

[Astellas Pharma] Astellas Pharma announced that China’s NMPA has approved VYLOYTM, in combination with fluoropyrimidine- and platinum-containing chemotherapy, for the first-line treatment of patients with locally advanced unresectable or metastatic HER2-negative gastric or gastroesophageal junction adenocarcinoma whose tumors are claudin 18.2 positive.

Mechanisms of KRAS Inhibitor Resistance in KRAS-Mutant Colorectal Cancer Harboring Her2 Amplification and Aberrant KRAS Localization

January 6, 2025

[NPJ Precision Oncology] Scientists investigated intrinsic resistance mechanisms to KRAS inhibitors using patient-derived colorectal cancer cells (CRC-PDCs). They found that KRAS-mutated CRC-PDCs could be divided into at least an EGFR pathway-activated group and a PI3K/AKT pathway-activated group.

LncRNA MIR210HG Promotes the Proliferation of Colon Cancer Cells by Inhibiting Ferroptosis Through Binding to PCBP1

January 6, 2025

[Scientific Reports] Researchers assessed MIR210 host gene (MIR210HG) expression in colon cancer cell lines and tissues, and examined the effects of its overexpression and knockdown on cell proliferation.

Eicosapentaenoic Acid Enhances Intestinal Stem Cell-Mediated Colonic Epithelial Regeneration by Activating the LSD1-WNT Signaling Pathway

January 3, 2025

[Journal of Advanced Research] Researchers investigated the regulatory role and mechanism of eicosapentaenoic acidin colonic epithelial regeneration, specifically from the perspective of intestinal stem cells.

THBS2+ Cancer-Associated Fibroblasts Promote EMT Leading to Oxaliplatin Resistance via COL8A1-Mediated PI3K/AKT Activation in Colorectal Cancer

January 2, 2025

[Molecular Cancer] Together with single-cell RNA sequencing and spatial transcriptomics analyses, scientists identified THBS2 specifically derived from subsets of cancer associated fibroblasts (CAFs), termed THBS2 + CAFs, which could promote oxaliplatin resistance by interacting with malignant cells via the collagen pathway in colorectal cancer.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.