Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

TrpA1 Is a Shear Stress Mechanosensing Channel Regulating Intestinal Stem Cell Proliferation in Drosophila

[Science Advances] Scientists demonstrated that shear stress sensing regulated intestine stem cell proliferation and epithelial cell number in adult Drosophila.

PROX1 Induction by Autolysosomal Activity Stabilizes Persister-Like State of Colon Cancer via Feedback Repression of the NOX1-mTORC1 Pathway

[Cell Reports] Researchers showed that enhanced autolysosomal activity mediated by mTORC1 inhibition induced PROX1 expression and that PROX1 induction in turn inhibited NOX1-mTORC1 activation.

Particulate Matter 10 Exposure Affects Intestinal Functionality in Both Inflamed 2D Intestinal Epithelial Cell and 3D Intestinal Organoid Models

[Frontiers In Immunology] The authors established chronically inflamed intestinal epithelium models utilizing two-dimensional (2D) human intestinal epithelial cells and 3D human intestinal organoids in order to examine the deleterious effects of particulate matter (PM) 10 in human intestine-like in vitro models.

Side Population Cells Derived from hUCMSCs and hPMSCs Could Inhibit the Malignant Behaviors of TN+ Colorectal Cancer Cells from Modifying Their O-Glycosylation Status

[Stem Cell Research & Therapy] Side population cells were isolated from human umbilical cord mesenchymal stem cells (MSCs) and human placenta MSCs. TN+ cells and matching Tn cells were isolated from human colorectal cancer cell lines LS174T and HT-29 by immune magnetic beads.

Clostridium butyricum Inhibits Epithelial–Mesenchymal Transition of Intestinal Carcinogenesis through Downregulating METTL3

[Cancer Science] Investigators found that methyltransferase-like 3 (METTL3) showed a positive correlation with proliferation, epithelial–mesenchymal transition, DNA repair, metastasis, and invasion in a database analysis.

An Epigenetic Signature of Advanced Colorectal Cancer Metastasis

[iScience] The authors identified a signature of advanced colorectal cancer metastasis by performing whole genome-scale DNA methylation and full transcriptome analyses of paired primary cancers and liver metastases from colorectal cancer patients.

Early Onset, Development, and Histological Features of Gastric Signet-Ring Cell Carcinoma

[Frontiers In Oncology] Three hundred and sixty-two patients with differentiated adenocarcinoma with signet-ring cells were enrolled. Histomorphological and immunohistochemical features and patterns of the specimens were observed in detail.

LRRC8A Promotes the Initial Development of Oxaliplatin Resistance in Colon Cancer Cells

[Heliyon] Researchers investigated the effects of leucine-rich repeat-containing 8 A (LRRC8A) on oxaliplatin resistance in colon cancer cells. The cell viability was measured after oxaliplatin treatment with cell counting kit-8 assay.

Early Stage Gastric Adenocarcinoma: Clinical and Molecular Landscapes

[Nature Reviews Clinical Oncology] The authors highlight current knowledge of the molecular and cellular biology of gastric adenocarcinomas, summarize the current approaches to clinical management of the disease, and consider the role of novel management and/or treatment strategies.

The Conundrum of Helicobacter pylori-Associated Apoptosis in Gastric Cancer

[Trends in Cancer] Scientists address the conundrum of H. pylori-associated apoptosis and review distinct mechanisms induced in host cells that either promote or suppress apoptosis in gastric epithelial cells.

P38 Kinase in Gastrointestinal Cancers

[Cancer Gene Therapy] Investigators provide an overview of p38 and p38γ with respect to gastrointestinal cancers. Targeting p38γ is also discussed as a potential therapy for gastrointestinal cancers.

AstraZeneca Drops Skyrizi Rival after Seeing R&D Timeline Spiral

[Fierce Biotech] AstraZeneca is abandoning a play for the inflammatory bowel disease market. After seeing clinical trial timelines spiral, the Anglo-Swedish drugmaker has stopped development of a would-be rival to products sold by AbbVie and Johnson & Johnson.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.