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Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
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Oncolytics Biotech® Receives FDA Fast Track Designation for Pelareorep in 2L KRAS-Mutant MSS Metastatic Colorectal Cancer
[Oncolytics Biotech® Inc.] Oncolytics Biotech® Inc., announced that the US FDA has granted Fast Track Designation to pelareorep in combination with bevacizumab (Avastin®) and leucovorin, fluorouracil, irinotecan for the treatment of patients with KRAS-mutant, microsatellite-stable metastatic colorectal cancer in the second-line setting.
Dewpoint Therapeutics Doses First Patient in Phase Ia/IIa Trial DPTX3186 for the Treatment of Advanced Solid Tumors, Focused on Gastric Cancer
[Dewpoint Therapeutics, Inc.] Dewpoint Therapeutics, Inc. announced that the first patient has been dosed in a Phase Ia/IIa clinical trial evaluating its lead beta-catenin program in patients with advanced solid tumors, with a focus on gastric cancer.
Intestinal LKB1 Loss Drives a Premalignant Program Along the Serrated Cancer Pathway
[Gastroenterology] Investigators revealed that heterozygous Lkb1 loss is sufficient to push intestinal cells into a premalignant transcriptional program associated with serrated colorectal cancer.
Primary Human Gastric Cancer Cells Integrated Hydrogel Microcapsules for Personalized Drug Screening
[ACS Applied Materials & Interfaces] Researchers proposed an innovative platform to cultivate primary gastric cancer cells using microfluidic encapsulation, enabling three-dimensional tumor growth and clinical drug assessment.
Cytoplasm-Nucleus Shuttling of TET2: An Intrinsic Brake in Colorectal Cancer Progression
[Cell Death & Disease] Scientists observed a tumor-inhibitory effect of epithelial-mesenchymal transition/WNT pathway by promoting the cytoplasm-nucleus shuttling of TET2, which inhibited the progression of colorectal cancer.
Toll Signaling Controls Stem Cell Proliferation in Intestinal Regeneration and Tumorigenesis
[EMBO Reports] Researchers demonstrated a critical role for Toll in regulating intestinal stem cell activity through direct transcriptional control of PI3K and Akt in an insulin-independent manner.
Notch3 Regulates Pericyte Phenotypic Plasticity in Colorectal Cancer
[Communications Biology] The authors investigated the role of Notch3 signaling in pericyte phenotype and functions in colorectal cancer. Using lineage tracing approaches, they showed that murine tumor pericytes originate from normal tissue-resident pericytes, which proliferate inside tumors.
Senescence-Associated LncRNAs TRMP and TRMP-S Promote Gastric Cancer by Activating IGFL4
[Scientific Reports] Researchers explained the novel role of lncRNA TRMP and its splice variant lncRNA TRMP-S in gastric cancer development.
Comprehensive 16s rRNA Sequencing and Metabolomics to Investigate the Effect of Anticancer Bioactive Peptides Combined with Oxaliplatin on Gastric Cancer
[Scientific Reports] Scientists established a nude mouse model of anticancer bioactive peptides-oxaliplatin for gastric cancer. They investigate the diversity of gut microbiota and fecal metabolomics and the correlation between gut microbiota and metabolites.
Ginsenoside Rg5 Inhibits Colorectal Cancer, at Least Partially by Blocking the Lysosomal Degradation of Colorectal Cancer Cells
[Scientific Reports] Investigators demonstrated for the first time that Ginsenoside Rg5 (Rg5), a small-molecule compound isolated from red ginseng, significantly inhibited tumor growth of colorectal cancer in mouse models.
Molecular Features and Clinical Significance of Cancer-Associated Fibroblasts in Colorectal Cancer
[Molecular Biology of The Cell] Scientists explored various facets of the involvement of Cancer-Associated Fibroblasts (CAFs) in the progression of colorectal cancer (CRC), and the potential clinical significance of targeting CAFs or CAFs-derived molecules in the context of CRC therapy.
Obesity Impairs Gut Repair via AFABP-Mediated Iron Overload in Intestinal Stem Cells
[Nature Metabolism] Scientists showed that adipocyte fatty acid-binding protein (AFABP), an adipokine involved in fatty acid transport, impedes intestinal repair by disrupting iron homeostasis in intestinal stem cells.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
