Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

METTL3 Promotes Colorectal Cancer Progression through Activating JAK1/STAT3 Signaling Pathway

[Cell Death & Disease] Investigators revealed that upregulated methyltransferase-like 3 (METTL3) in colorectal cancer exerted both methyltransferase activity-dependent and -independent functions in gene regulation.

Loss of Claudin-3 Expression Increases Colitis Risk by Promoting Gut Dysbiosis

[Gut Microbes] Analysis of mouse and human IBD cohorts helped examine claudin-3 (CLDN3) expression in IBD. The causal role was determined by modeling CLDN3 loss of expression during experimental colitis.

Paneth Cell-Derived iNOS Is Required to Maintain Homeostasis in the Intestinal Stem Cell Niche

[Journal of Translational Medicine] Scientists investigated the expression pattern of inducible nitric oxide synthase (iNOS) within crypts and explore its function in the homeostatic maintenance of the intestinal stem cell niche.

An EMC-Hpo-Yki Axis Maintains Intestinal Homeostasis under Physiological and Pathological Conditions

[Development] The authors found that the evolutionarily conserved endoplasmic reticulum membrane protein complex negatively regulated intestinal stem cell proliferation and intestinal homeostasis.

Elevated Expression of CXCL3 in Colon Cancer Promotes Malignant Behaviors of Tumor Cells in an ERK-Dependent Manner

[BMC Cancer] Researchers indicated that CXC chemokine ligand 3 (CXCL3) was upregulated in colon adenocarcinoma and played a crucial role in the control of malignant behaviors of tumor cells.

CircVMP1 Promotes Glycolysis and Disease Progression by Upregulating HKDC1 in Colorectal Cancer

[Environmental Toxicology] Investigators explored the mechanism by which circVMP1 regulated tumor glycolysis and its related pathways in promoting colorectal cancer cell proliferation and metastasis.

Curcumin Suppresses the Wnt/β-Catenin Signaling Pathway by Inhibiting NKD2 Methylation to Ameliorate Intestinal Ischemia/Reperfusion Injury

[Kaohsiung Journal Of Medical Sciences] To determine whether the protective effect of curcumin (CCM) on intestinal ischemia/reperfusion injury was mediated by epigenetic effects on Wnt/β-catenin signaling, the effect of CCM was examined in vivo and in vitro.

B7-H3 Regulates Anti-Tumor Immunity and Promotes Tumor Development in Colorectal Cancer

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors describe the functions played by B7 homologue 3 (B7-H3) in colorectal cancer from both immune and non-immune elements.

AbbVie Buys Immunogen, Maker of Targeted Cancer Drugs, for $10 Billion

[STAT] AbbVie announced that the company will pay $10 billion to the biotech firm Immunogen for the acquirement of an approved treatment for ovarian cancer and buying into a burgeoning area of oncology.

ID1 Expressing Macrophages Support Cancer Cell Stemness and Limit CD8+ T Cell Infiltration in Colorectal Cancer

[Nature Communications] Researchers reported that high expression of inhibitor of differentiation 1 (ID1) in tumor-associated macrophages correlated with poor outcome in patients with colorectal cancer.

Intestinal Paneth Cell Differentiation Relies on Asymmetric Regulation of Wnt Signaling by Daam1/2

[Science Advances] Researchers reported that the Dishevelled-associated activator of morphogenesis 1 (Daam1) and its paralogue Daam2 asymmetrically regulated canonical and noncanonical Wnt signaling.

University of Bonn Receives Three ERC Consolidator Grants

[University of Bonn] Another big success for the University of Bonn in securing grants from the European Research Council (ERC), with three researchers receiving an ERC Consolidator Grant: Drs. Jan Hasenauer, Florian I. Schmidt, and Evgeny Shinder.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.