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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
TRMT6-Mediated tRNA m1a Modification Acts As a Translational Checkpoint of Histone Synthesis and Facilitates Colorectal Cancer Progression
[Nature Cancer] Scientists found that tRNA N1-methyladenosine (m1A) methyltransferase TRMT6 is upregulated in human CRC tissues and high TRMT6 expression correlates with poor survival in patients with CRC.
Dioscin Induces Ferroptosis to Suppress the Metastasis of Gastric Cancer through the SLC7A11/GPX4 Axis
[Free Radical Research] Dioscin, a compound extracted from the Paris polyphylla rhizomes roots, induced ferroptosis through SLC7A11/GPX4 axis, and was involved in the regulation of inhibiting metastasis of gastric cancer.
Systemic Delivery of Cadherin 17-Specific CAR T Cells Allows Effective and Safe Targeting of Colorectal Cancer Liver Metastases
[Science Translational Medicine] The authors identified cadherin-17 (CDH17) as a candidate antigen for CAR T cell therapy of colorectal cancer (CRC) liver metastases. When used in a CRC liver xenograft model, CDH17 CAR T cells efficiently suppress tumor growth upon either systemic or locoregional administration.
Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer
[New England Journal of Medicine] This trial showed significantly longer progression-free survival and overall survival with first-line treatment with EC+mFOLFOX6 than with standard care among patients with BRAF V600E–mutated metastatic colorectal cancer.
Loss of Colonic Fidelity Enables Multilineage Plasticity and Metastasis
[Nature] Scientists identified the chromatin-remodelling enzyme ATRX as a key regulator of colonic lineage fidelity and metastasis in colorectal cancer.
Mechanism and Role of Ferroptosis in the Development of Gastric Cancer
[Clinical and Experimental Medicine] The authors elucidate the functional significance of ferroptosis in the pathogenesis of gastric cancer, review the dysregulated metabolic pathways associated with this cell death process, and elucidate the intricate interactions among ferroptosis-related signaling cascades.
Xilio Therapeutics Announces Updated Phase II Data for Vilastobart, a Tumor-Activated Anti-CTLA-4, in Combination with Atezolizumab in Patients with Metastatic Microsatellite Stable Colorectal Cancer
[Xilio Therapeutics, Inc. ] Xilio Therapeutics, Inc. announced updated data from its ongoing Phase II clinical trial evaluating vilastobart, a tumor-activated, Fc-enhanced, high affinity binding anti-CTLA-4, in combination with atezolizumab in patients with metastatic metastatic microsatellite stable colorectal cancer.
Sodium/Hydrogen Exchanger 8 Affects Sheet Migration of Human Intestinal Epithelial Cells (HT29-MTX) by Influencing the Actin Cytoskeletal Rearrangement
[American Journal of Physiology-Cell Physiology] Since ulcerative colitis is characterized by repeated mucosal injury, scientists investigated the role of gastrointestinal Na+/H+ transporter 8 (NHE8) in intestinal wound repair, by accessing its effect on intracellular pH regulation, cell proliferation and migration.
Restoring Calcium Crosstalk between ER and Mitochondria Promotes Intestinal Stem Cell Rejuvenation through Autophagy in Aged Drosophila
[Nature Communications] Researchers showed that genetically restoring mitochondrial calcium can reverse intestinal stem cell functional decline and promote intestinal homeostasis by activating autophagy in aged flies.
Spike-In Enhanced Phosphoproteomics Uncovers Synergistic Signaling Responses to MEK Inhibition in Colon Cancer Cells
[Nature Communications] Scientists demonstrated that spike-in enhanced detection in DIA effectively identified synergistic signaling responses in colorectal cancer cells, presenting a valuable tool for uncovering new therapeutic targets and strategies in cancer treatment.
Neurotensin Inhibits AMPK Activity and Concurrently Enhances FABP1 Expression in Small Intestinal Epithelial Cells Associated with Obesity and Aging
[Experimental & Molecular Medicine] Utilizing Drosophila and mouse models in vivo, as well as mouse and human small intestinal epithelial organoids or monolayers ex vivo, scientists determine the targets of neurotensin and AMPK associated with obesity and aging.
Snora54 Negatively Regulates Self-Renewal of Intestinal Stem Cells and Gut Regeneration via Suppression of Notch2 Signaling
[Science Advances] Investigators identified a small nucleolar RNA (Snora54) that was highly expressed in the nucleolus of intestinal stem cells (ISCs). Snora54 knockout enhanced the self-renewal capacity of ISCs and intestinal regeneration.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
