Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Tempus Receives FDA Approval for Tumor Only xT CDx, Enabling Migration of its Entire DNA Solid Tumor Portfolio

May 29, 2026

[Tempus AI, Inc.] Tempus AI, Inc. announced that the US FDA has granted approval for a tumor-only indication for its xT companion diagnostic next-generation sequencing platform.

Macrophage USP9X Attenuates Colitis by Restricting Oncostatin M Production via K27-Linked Deubiquitination of STAT1

May 29, 2026

[Cellular & Molecular Immunology] Researchers identified ubiquitin-specific peptidase 9X (USP9X) as a critical negative regulator of intestinal inflammation. USP9X expression is reduced in Ulceralative Colitis patients and inversely correlates with disease severity.

MRM Health Rewarded a €2.6M VLAIO Research Grant to Accelerate the Development of Novel Therapeutics That Redefine the Treatment of Immunemediated Inflammatory Diseases

May 28, 2026

[MRM Health] MRM Health announced that it has been awarded a research grant of €2.6M from Flanders Innovation and Entrepreneurship (VLAIO). The three-year, non-dilutive grant will advance research on gut ecosystem remediation and modification of diseases driven by a dysbiotic inflammatory microbime.

A Dual-Pathway Wnt-IL-13 Fusion Protein Enhances Human Intestinal Regeneration through Tuft Cell Activation

May 28, 2026

[Journal of Biological Chemistry] Researchers reported the engineering and functional validation of a synthetic Wnt-IL-13 fusion protein that simultaneously activates both the Wnt and IL-4/IL-13 signaling pathways to enhance human intestinal tuft cell activity.

Iron-Addicted Colorectal Cancers Exploit Heme-Complex II Axis to Resist Oxidative Cell Death

May 28, 2026

[Cell Metabolism] Using multi-omics profiling, CRISPR screening, and in vivo models, scientists uncovered a heme-succinate dehydrogenase-coenzyme Q axis that enables colorectal cancer cells to buffer iron-induced oxidative stress.

NAALADL1 Modulates Cellular Resistance to Tumor Treating Fields in Colorectal Cancer

May 28, 2026

[NPJ Precision Oncology] Scientists highlighted significant heterogeneity in colorectal cancer cell line responses to tumor treating fields and identify N-acetylated alpha-linked acidic dipeptidase-like 1 (NAALADL1) as a key modulator of resistance.

A cDC1-NK/T-Malignant Cell Circuit Drives Immunogenic Remodeling Under PD-1 Blockade in Gastric Cancer

May 28, 2026

[Cancer Science] Researchers performed scRNA-seq of gastric cancer (GC) biopsy specimens from treatment-naïve patients and patients treated with chemotherapy, chemotherapy plus nivolumab (CN), or chemotherapy plus trastuzumab, and found that CN treatment enhanced natural killer/T cell-associated immunogenicity in GC TMEs.

Catestatin Peptide Impedes Melanoma Progression and Drug Resistance by Reprogramming Oncogenic Signaling Pathways

May 28, 2026

[Oncogenesis] Investigators reported for the first time the involvement of Catestatin peptide in carcinogenesis, with melanoma identified as unexplored and therapeutically relevant context.

Concurrent Genetic and Non-Genetic Resistance Mechanisms to KRAS Inhibition in Colorectal Cancer

May 28, 2026

[Cancer Cell] Scientists used targeted exome sequencing and spatial transcriptomics on patient-matched colorectal cancer biopsies following combined treatment with KRASG12C and EGFR inhibitors.

Gastrointestinal Tuft Cells: Recent Insights and Next Questions

May 28, 2026

[Science Immunology] The authors explore critical outstanding topics in gastrointestinal tuft cell biology, including what their evolved functions are beyond helminth sensing, how they detect different pathogens and dietary challenges, and why small intestinal tuft cells proliferate dramatically during type 2 responses.

Human Inflammatory Bowel Disease-on-a-Chip for Modelling Disease Progression, Cancer Initiation, and Sex-Specific Effects

May 28, 2026

[Nature Biomedical Engineering] Researchers replicated IBD hallmarks in human-derived organ-on-a-chip devices lined by colon epithelial cells from individuals with IBD when interfaced with matched fibroblasts, cultured under flow, exposed to peristalsis-like motions and perfused with circulating immune cells.

PTEN Deficiency Impairs MHC-I-Mediated Tumor Immunity via NRF2-Dependent Autophagy in Microsatellite Stable Colorectal Cancer

May 28, 2026

[Gut] Scientists identified a previously unrecognised ‘NRF2-autophagy’ axis as a driver of immune evasion in phosphatase and tensin homologue (PTEN)-deficient microsatellite stable colorectal cancer.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.