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Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
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PSMD14-Mediated PFKFB2 Deubiquitination Activates H3K27 Lactylation to Drive Cancer Stemness in Gastric Adenocarcinoma
[Cell Death & Differentiation] The authors discovered that highly expressed PSMD14 strengthens tumor stemness and drives tumor progression by increasing glycolysis and lactate accumulation, which activates H3K27 lactylation and turns to enhance the expression of PSMD14 and SOX9.
Goblet Cell-Expressed Microprotein FXYD3 Determines Gut Homeostasis by Maintaining Mucus Barrier Integrity
[Cell Reports] Investigators identified a function for the microprotein FXYD domain-containing transport regulator 3 (FXYD3) in goblet cells in regulating mucus layer formation to maintain intestinal homeostasis.
JMJD3 Upregulates ALOX5 to Drive Malignancy and Concomitant Ferroptosis Sensitivity in Gastric Cancer
[Cell Death & Disease] Researchers demonstrated that JMJD3 is highly expressed in both gastric cancer tissues and patient-derived chemotherapy-resistant xenograft models and contributes to increased malignancy and chemoresistance.
EGR4 Transcriptionally Upregulates GDF15 to Promote Gastric Cancer Metastasis
[Cell Death & Disease] Scientists integrated single-cell RNA sequencing of primary tumors and matched metastatic lymph nodes from six gastric cancer patients to identify a metastatic epithelial subpopulation characterized by early growth response (EGR) 4 overexpression.
L-Glutamate Enables the EGFR-MEK-ERK-mTFB2 Axis to Enhance Mitochondrial Biogenesis in Intestinal Stem Cells
[Stem Cell Research & Therapy] The authors examined the role of L-glutamate in regulating cell mitochondrial biosynthesis using in vivo piglets, ex vivo porcine intestinal organoids, and in vitro IPEC-J2 cells.
The CBS/H2S Axis Regulates Intestinal Stem Cell Homeostasis and Radiation-Induced Intestinal Damage
[Stem Cell Research & Therapy] Intestinal epithelium specific conditional cystathionine-β-synthase (CBS) knockout mice were generated by crossing CBSfl/+ mice with Villin-CreERT2 mice.
NFATc1-Mediated Activation of the Pentose Phosphate Pathway and Cell Cycle Dysregulation Collectively Drive Tumor Progression
[Oncogenesis] Researchers demonstrated that nuclear factor of activated T-cells c1 (NFATc1) enhances NAD kinase expression, elevating intracellular NADP+ levels to activate the pentose phosphate pathway, thereby boosting proliferation.
Targeting Ferroptosis in Helicobacter pylori‑Associated Gastric Cancer Development: From Molecular Mechanisms to Application Prospects
[International Journal of Oncology] Scientists identified key regulators of ferroptosis at distinct pathological stages, thereby providing insight of novel strategies for the management of precancerous lesion‑related diseases and gastric cancer.
Sanger Scientists Receive Major Grant to Study Rise of Early Onset Colorectal Cancer
[Wellcome Sanger Institute] Professor Sir Mike Stratton and Dr Trevor Lawley, together with Dr Paul Brennan have been awarded a €10.4 million grant, enabling their team to investigate the causes of early onset colorectal cancer.
Circulating Tumor DNA-Guided Adjuvant Therapy in Locally Advanced Colon Cancer: The Randomized Phase II/III DYNAMIC-III Trial
[Nature Medicine] In this multicenter, randomized, Phase II/III trial, patients with stage III colon cancer underwent ctDNA testing five–six weeks after surgery and were assigned to ctDNA-guided or standard management.
Engineered Decellularized Matrix Hydrogels with Crypt–Villus Topography for Forming Functional Intestinal Epithelium
[Small] A sacrificial hydrogel mold with negative crypt/villus features is first fabricated using digital light processing 3D printing of poly(ethylene glycol)–norbornene–tyramine thiol–norbornene hydrogels.
Unraveling Enteroendocrine Cell Lineage Dynamics and Associated Gene Regulatory Networks during Intestinal Development
[Biology Open] The authors used mouse embryos, hPSC-derived intestinal organoid models and single-cell transcriptomics to characterize enteroendocrine cell lineages and dynamics during development.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
