Category Archives: Intestinal Cell

Intestinal Cell News is an online publication and email newsletter that curates the latest research using intestinal cells.
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Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.

Histone Methyltransferase WHSC1 Inhibits Colorectal Cancer Cell Apoptosis via Targeting Anti-Apoptotic BCL2

Scientists revealed how WHSC1 regulates tumorigenesis and chemosensitivity of colorectal cancer.
[Cell Death Discovery]
Wang, Y., Zhu, L., Guo, M., Sun, G., Zhou, K., Pang, W., Cao, D., Tang, X., & Meng, X. (2021). Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2. Cell Death Discovery, 7(1), 1–9. https://doi.org/10.1038/s41420-021-00402-6 Cite
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Targeting the m6A-Reader Protein YTHDF1 Effectively Re-Sensitizes Cisplatin Resistant Colon Cancer Cells through Modulating the Glutaminase (GLS)-Mediated Glutamine Metabolism

Researchers report YTHDF1 was significantly upregulated in human colon tumors and cell lines. Overexpression of YTHDF1 decreased the cisplatin sensitivity of colon cancer cells.
[Molecular Therapy-Oncolytics]
Chen, P., Liu, X., Lin, X., Gao, L., Zhang, S., & Huang, X. (2021). Targeting the m6A-reader Protein YTHDF1 Effectively Re-Sensitizes Cisplatin Resistant Colon Cancer Cells through Modulating the Glutaminase (GLS)-Mediated Glutamine Metabolism. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.01.001 Cite
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AMP-Activated Protein Kinase-Induced β-Catenin Degradation through Parkin Phosphorylation Reverses Chemotherapy Resistance of Colon Cancer Cells

Scientists explored the mechanism regarding AMP-activated protein kinase-mediated β-catenin degradation in chemotherapy resistance in colon cancer. β-catenin was upregulated in colon cancer tissues and cells, as it was positively correlated with the malignancy and poor prognosis, and chemotherapy resistance of colon cancer.
[Molecular Therapy-Nucleic Acids]
Yu, Y., Tian, Z., Yang, L., Zhu, D., Ding, X., Jing, X., Liu, H., & Guo, P. (2021). AMP-activated protein kinase-induced β-catenin degradation through Parkin phosphorylation reverses chemotherapy resistance of colon cancer cells. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.01.006 Cite
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HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor

The authors showed that HAND1 is expressed in aggressive gastrointestinal stromal tumor, modulating KIT and core transcription factor expression and supporting proliferative cellular programs.
[Clinical Cancer Research]
Hemming, M. L., Coy, S., Lin, J.-R., Andersen, J. L., Przybyl, J., Mazzola, E., Ahmed, A. H. A., Rijn, M. van de, Sorger, P. K., Armstrong, S. A., Demetri, G. D., & Santagata, S. (2021). HAND1 and BARX1 act as transcriptional and anatomic determinants of malignancy in gastrointestinal stromal tumor. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3538 Cite
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A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Non-Essential Modes of Oncogenic Transformation

CRISPR/Cas9-mediated ARID1A knockout in primary TP53-/- human gastric organoids induced morphologic dysplasia, tumorigenicity and mucinous differentiation.
[Cancer Discovery]
Lo, Y.-H., Kolahi, K. S., Du, Y., Chang, C.-Y., Krokhotin, A., Nair, A., Sobba, W. D., Karlsson, K., Jones, S. J., Longacre, T. A., Mah, A. T., Tercan, B., Sockell, A., Xu, H., Seoane, J. A., Chen, J., Shmulevich, I., Weissman, J. S., Curtis, C., … Kuo, C. J. (2021). A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-1109 Cite
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NTPDase8 Protects Mice from Intestinal Inflammation by Limiting P2Y6 Receptor Activation: Identification of a New Pathway of Inflammation for the Potential Treatment of IBD

Scientists investigated the role of nucleoside triphosphate diphosphohydrolase-8 (NTPDase8) in intestinal inflammation. Human intestinal epithelial cells express NTPDase8 and P2Y6 similarly as in mice.
[Gut]
Salem, M., Lecka, J., Pelletier, J., Marconato, D. G., Dumas, A., Vallières, L., Brochu, G., Robaye, B., Jobin, C., & Sévigny, J. (2021). NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD. Gut. https://doi.org/10.1136/gutjnl-2020-320937 Cite
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Model Complexity as Determining Factor for In Vitro Nanosafety Studies: Effects of Silver and Titanium Dioxide Nanomaterials in Intestinal Models

Researchers studied the cytotoxic, proinflammatory, and DNA damaging properties of polyvinylpyrrolidone‐capped silver and titanium dioxide engineered nanomaterials in four in vitro models of increasing complexity—from proliferating Caco‐2 and HT29‐MTX‐E12 monocultures to long‐term transwell triple cultures including THP‐1 macrophages to reproduce the human intestine in healthy versus inflamed‐like state.
[Small]
Kämpfer, A. A. M., Busch, M., Büttner, V., Bredeck, G., Stahlmecke, B., Hellack, B., Masson, I., Sofranko, A., Albrecht, C., & Schins, R. P. F. (n.d.). Model Complexity as Determining Factor for In Vitro Nanosafety Studies: Effects of Silver and Titanium Dioxide Nanomaterials in Intestinal Models. Small, n/a(n/a), 2004223. https://doi.org/https://doi.org/10.1002/smll.202004223 Cite
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Proteomics Analysis of Human Intestinal Organoids during Hypoxia and Reoxygenation as a Model to Study Ischemia-Reperfusion Injury

Investigators demonstrated the use of human small intestinal organoids to model ischemia-reperfusion injury by exposing organoids to hypoxia and reoxygenation.
[Cell Death & Disease]
Kip, A. M., Soons, Z., Mohren, R., Duivenvoorden, A. A. M., Röth, A. A. J., Cillero-Pastor, B., Neumann, U. P., Dejong, C. H. C., Heeren, R. M. A., Olde Damink, S. W. M., & Lenaerts, K. (2021). Proteomics analysis of human intestinal organoids during hypoxia and reoxygenation as a model to study ischemia-reperfusion injury. Cell Death & Disease, 12(1), 1–13. https://doi.org/10.1038/s41419-020-03379-9 Cite
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IGFBPs Mediate IGF-1’s Functions in Retinal Lamination and Photoreceptor Development during Pluripotent Stem Cell Differentiation to Retinal Organoids

Researchers investigated the expression of insulin growth factor binding proteins and their role in the generation of human retinal organoids from human pluripotent stem cells.
[Stem Cells]
IGFBPs mediate IGF‐1’s functions in retinal lamination and photoreceptor development during pluripotent stem cell differentiation to retinal organoids - Zerti - - STEM CELLS - Wiley Online Library. (n.d.). Retrieved January 15, 2021, from https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3331?af=R Cite
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Semiconducting Polymer Nanoparticles for Photothermal Ablation of Colorectal Cancer Organoids

Tumor organoid technology was used to evaluate the ablative potential of CD44-targeted polymer nanoparticles using hyaluronic acid (HA) as the targeting agent and coating it onto hybrid donor acceptor polymer particles (HDAPPs) to form HA-HDAPPs.
[Scientific Reports]
McCarthy, B., Cudykier, A., Singh, R., Levi-Polyachenko, N., & Soker, S. (2021). Semiconducting polymer nanoparticles for photothermal ablation of colorectal cancer organoids. Scientific Reports, 11(1), 1532. https://doi.org/10.1038/s41598-021-81122-w Cite
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Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense

Using various models of intestinal cryptosporidiosis, the authors found that Cryptosporidium infection caused suppression of mitogen-activated protein kinase signaling in infected murine intestinal epithelial cells.
[Microorganisms]
He, W., Li, J., Gong, A.-Y., Deng, S., Li, M., Wang, Y., Mathy, N. W., Feng, Y., Xiao, L., & Chen, X.-M. (2021). Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense. Microorganisms, 9(1), 151. https://doi.org/10.3390/microorganisms9010151 Cite
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