Intestinal Cell News
Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
ROS-Induced Cytosolic Release of Mitochondrial PGAM5 Promotes Colorectal Cancer Progression by Interacting with MST3
[Nature Communications] Using colorectal cancer models, investigators showed that upon sensing excessive mitochondrial reactive oxygen species, phosphatase PGAM5, which normally localizes to the mitochondria, undergoes aberrant cleavage by presenilin-associated rhomboid-like protein, becoming released into the cytoplasm.
Identification of the Immune Infiltration and Biomarkers in Ulcerative Colitis Based on Liquid–Liquid Phase Separation-Related Genes
[Scientific Reports] Researchers determined the seven high accuracy diagnostic genes of ulcerative colitis (UC) patients and provided a new perspective on immunoregulation in UC pathogenesis.
Oxidative Stress Caused by 3-Monochloro-1,2-Propanediol Provokes Intestinal Stem Cell Hyperproliferation and the Protective Role of Quercetin
[Ecotoxicology and Environmental Safety] Scientists revealed that exposure to 3-MCPD led to a decrease in the number of enterocyte cells and an elevation in apoptosis levels, ultimately disrupting the intestinal epithelial barrier and its function.
Akkermansia muciniphila Identified as Key Strain to Alleviate Gut Barrier Injury through Wnt Signaling Pathway
[eLife] Researchers showed that fecal microbiota transplantation regulated gut microbiota and enhanced the protection of AIMD piglets against Escherichia coli K88 challenge, as demonstrated by reduced intestinal pathogen colonization and alleviated gut barrier injury.
TL1A Inhibition in Inflammatory Bowel Disease: A Pipeline Review
[BioDrugs] The authors review the role of TL1A in inflammatory bowel disease, evaluate the efficacy of anti-TL1A therapies in clinical trials, and discuss future directions for research and treatment.
Terminal Differentiation and Persistence of Effector Regulatory T Cells Essential for Preventing Intestinal Inflammation
[Nature Immunology] Researchers characterized distinct colonic effector Treg cell transcriptional programs. Attenuated T cell receptor (TCR) signaling and acquisition of substantial TCR-independent functionality seemed to facilitate the terminal differentiation of a population of colonic effector Treg cells that were distinguished by stable expression of the immunomodulatory cytokine IL-10.
The Lactate Receptor HCAR1 Drives the Recruitment of Immunosuppressive PMN-MDSCs in Colorectal Cancer
[Nature Immunology] Investigators found that activation of the lactate receptor HCAR1 signaling pathway induced the expression of chemokines CCL2 and CCL7 in colorectal tumor cells, leading to the recruitment of immunosuppressive CCR2+ polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) to the tumor microenvironment.
Pfizer Canada and Partners Announce Quality Improvement Grant Recipients for Canada’s Most Prevalent Cancers
[Pfizer (Canada Newswire)] Pfizer Canada, together with Rethink Breast Cancer, Colorectal Cancer Canada, Lung Health Foundation, Lung Cancer Canada, and the Quebec Lung Association, announced the 2024 recipients of a series of grants to help advance oncology care and innovation in Canada.
Low-Coverage Whole Genome Sequencing of Low-Grade Dysplasia Strongly Predicts Advanced Neoplasia Risk in Ulcerative Colitis
[Gut] The authors provided accurate advanced neoplasia (AN) risk stratification in ulcerative colitis patients with low-grade dysplasia (LGD). They hypothesized that the pattern and burden of somatic genomic copy number alterations (CNAs) in LGD lesions could predict future AN risk.
Intestinal Epithelial Ptpn23 Is Essential For Gut Barrier Integrity And Prevention Of Fatal Bacterial Translocation
[Journal of Crohn's & Colitis] Given the crucial function of such receptors in intestinal epithelial cells, researchers assessed the involvement of protein tyrosine phosphatase non-receptor type 23 (PTPN23) in intestinal homeostasis and epithelial proliferation.
SP-1-Activated LINC01016 Overexpression Promotes Gastric Cancer Invasion and Metastasis Through Inhibiting EIF4A3-Mediated MMP9 mRNA Decay
[Cell Death & Disease] Investigators showed that the expression of the long intergenic noncoding RNA 01016 (LINC01016) was significantly higher in gastric cancer tissues with lymph node metastasis (LNM) than those without LNM.
Bisdemethoxycurcumin and Curcumin Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice
[Journal of Agricultural and Food Chemistry] Scientists assessed curcumin (CUR) and bisdemethoxycurcumin (BDMC) in a DSS-induced colitis mouse model. Dietary administration of CUR or BDMC strengthened tight junction proteins, reduced inflammatory cytokine secretion, and attenuated intestinal inflammatory protein expression, thereby alleviating DSS-induced inflammatory bowel disease in mice.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.