Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

UNF Faculty Receive Patent for Discovering Cancer-Fighting Compound That Could ‘Turn Off’ Cancer

[University of North Florida] Three University of North Florida (UNF) researchers have been awarded a US patent for a targeted cancer-fighting compound, or peptoid, that the team has discovered targets certain breast, colon and lung cancers and stops them from progressing. This promising discovery could lead to significantly better patient outcomes for difficult to treat cancers.

Genetically Programmable Cell Membrane-Camouflaged Nanoparticles for Targeted Combination Therapy of Colorectal Cancer

[Signal Transduction and Targeted Therapy] Scientists introduced a cell membrane biomimetic nanodrug platform termed MPB-3BP@CM nanoparticles (NPs). Notably, blocking CD47 with MPB-3BP@CM NPs enhanced the phagocytosis of colorectal cancer cells by macrophages.

Development of an Evaluation System Using Intestinal Organoids for Drug Efflux Transport Analysis by an Imaging Approach

[Journal of Pharmaceutical Sciences] Researchers investigated the effects of passage and cryopreservation of enteroids, organoids derived from intestine. They focused on P-glycoprotein (p-gp) and compared the transfer rates of rhodamine 123 into the lumen of enteroids with and without a P-gp inhibitor.

Human Gastric Cancer Progression and Stabilization of ATG2B through RNF5 Binding Facilitated by Autophagy-Associated CircDHX8

[Cell Death & Disease] Researchers investigated the mechanism underlying the role of hsa_circ_003899 (circDHX8) in the malignancy of gastric cancer (GC). CircDHX8 was identified as upregulated and shown to enhance the malignant progression in GC cells by promoting cellular autophagy.

Divergent Responses of Human Intestinal Organoid Monolayers Using Commercial In Vitro Cytotoxicity Assays

[PLOS One] Given the complexity of organoid cultures, including donor-driven variability, the authors investigated drug-treated, tissue stem cell-derived human intestinal organoid responses with commonly used cell cytotoxicity assay kits.

Tumor Cell-Derived Serglycin Promotes IL-8 Secretion of CAFs in Gastric Cancer

[British Journal of Cancer] Scientists revealed the mechanisms of the preferential production of IL-8 by cancer-associated fibroblasts (CAFs) in gastric cancer. Serglycin secreted by tumour cells activated the CD44/c-Myc pathway to upregulate lysine[K]-specific demethylase 5B expression, thereby promoting IL-8 production in CAFs.

Patient-Derived Organoid Biobank Identifies Epigenetic Dysregulation of Intestinal Epithelial MHC-I as a Novel Mechanism in Severe Crohn’s Disease

[Gut] Using intestinal epithelial organoids generated from mucosal biopsies, scientists investigated the role of intestinal epithelial DNA methylation in Crohn’s disease pathogenesis.

MYG1 Drives Glycolysis and Colorectal Cancer Development through Nuclear-Mitochondrial Collaboration

[Nature Communications] The authors uncovered that melanocyte proliferating gene 1 (MYG1) expression was upregulated in colorectal cancer (CRC) progression and MYG1 promoted glycolysis and CRC progression independent of its exonuclease activity.

Milk Fat Globule-Epidermal Growth Factor 8 (MFGE8) Prevents Intestinal Fibrosis

[Gut] Primary human intestinal myofibroblasts treated with milk fat globule-epidermal growth factor 8 (MFGE8) were evaluated regarding the mechanism of their antifibrotic response, and the action of MFGE8 was tested in two experimental intestinal fibrosis models.

Isthmus Progenitor Cells Contribute to Homeostatic Cellular Turnover and Support Regeneration Following Intestinal Injury

[Cell] Scientists studied crypt epithelial cells in an unbiased fashion via high-resolution single-cell profiling. These studies, combined with in vivo lineage tracing, showed that Lgr5 was not a specific intestinal stem cell marker and that stemness potential existed beyond the crypt base and resided in the isthmus region, where undifferentiated cells participated in intestinal homeostasis and regeneration following irradiation injury.

Time-Resolved Fate Mapping Identifies the Intestinal Upper Crypt Zone as an Origin of Lgr5+ Crypt Base Columnar Cells

[Cell] Using a kinetic reporter for time-resolved fate mapping and Fgfbp1-CreERT2 lineage tracing, the authors established that Fgfbp1+ cells were multi-potent and gave rise to Lgr5+ cells, consistent with their intestinal stem cell function.

23andMe and the Colorectal Cancer Alliance Collaborate to Help Advance Colorectal Cancer Research in the Black Community

[23andMe] 23andMe and the Colorectal Cancer Alliance announced a collaboration to help advance research on colorectal cancer in the Black/African American community. The Genetic Insights into Colorectal Cancer in the Black Community Study is part of 23andMe’s continued efforts to raise awareness about important health conditions that touch many individuals but disproportionately impact the Black community.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.