Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Cholinergic Neurons Trigger Epithelial Ca2+ Currents to Heal the Gut

[Nature] Scientists found that down-regulation of the conserved cholinergic enzyme Acetylcholinesterase4 in the gut epithelium enables acetylcholine from specific TNF/Egr5-sensing cholinergic neurons to activate nicotinic receptors in innervated enterocytes.

Combined Inhibition of Bcl-2 Family Members and YAP Induces Synthetic Lethality in Metastatic Gastric Cancer with RASA1 and NF2 Deficiency

[Molecular Cancer] Investigators identified molecular drivers for metastasis and devise corresponding therapeutic strategies. They performed an unbiased in vivo genome-wide CRISPR/Cas9 knockout screening in peritoneal dissemination using genetically engineered gastric cancer mouse models.

Orally-Delivered, Cytokine-Engineered Extracellular Vesicles for Targeted Treatment of Inflammatory Bowel Disease

[Small] In a murine model of colitis, Gal-IL10-extracellular vesicles alleviated inflammatory bowel disease symptoms including inflammatory responses and disrupted colonic barriers.

CRNDE Mediated hnRNPA2B1 Stability Facilitates Nuclear Export and Translation of KRAS in Colorectal Cancer

[Cell Death & Disease] Investigators found that the colorectal neoplasia differentially expressed (CRNDE)/heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) axis was notably elevated in colorectal cancer (CRC) and was strongly associated with poor prognosis of patients, while also significantly promoting CRC cell proliferation and metastasis both in vitro and in vivo.

Emerging Aeromonas Enteric Infections: Their Association with Inflammatory Bowel Disease and Novel Pathogenic Mechanisms

[Microbiology Spectrum] An A. veronii strain (AS1) isolated from intestinal biopsies of a patient with inflammatory bowel disease was used for pathogenic mechanism investigation, and Escherichia coli K12 was used as a bacterial control. HT-29 cells were used as a model of human intestinal epithelium.

Tripartite Motif Containing 59 Mediates Protective Anti-oxidative Effects in Intestinal Injury Through Nrf2 Signaling

[International Immunopharmacology] Scientists identified TRIM59 as a critical and novel endogenous suppressor of kelch-like ECH-associated protein 1 (KEAP1) and also determined that TRIM59 was a KEAP1-interacting partner protein that catalyzes its ubiquitination and degradation in intestinal epithelial cells.

Epigenomic Analysis Reveals a Unique DNA Methylation Program of Metastasis-Competent Circulating Tumor Cells in Colorectal Cancer

[Scientific Reports] Researchers characterized the DNA methylation profile of metastasis-competent circulating tumor cells in colorectal cancer (CRC). The DNA methylome of the human CRC-derived cell line CTC-MCC-41 was analyzed and compared with primary and metastatic CRC cells.

Suppression of Mir-150–5p Attenuates the Anti-inflammatory Effect of Glucocorticoids in Mice with Ulcerative Colitis

[Molecular Immunology] Investigators elucidated the mechanisms of mir-150–5p regulation on glucocorticoid resistance. An ulcerative colitis mouse model was used to evaluate changes in ulcerative colitis symptoms, inflammatory factors, and glucocorticoid resistance-related gene expression.

Co-Administration of Thymoquinone and Propolis in Liposomal Formulations as a Potential Approach for Treatment of Acetic Acid-Induced Ulcerative Colitis: Physiological and Histopathological Analysis

[AAPS Pharmscitech] Scientists assessed the potential of liposomal formulations of thymoquinone and Egyptian propolis extract in combination therapy to improve their therapeutic efficacy against ulcerative colitis in order to maximize the potential of their beneficial clinical effects.

Therapeutic Mechanism of Liangxue-Guyuan-Yishen Decoction on Intestinal Stem Cells and Tight Junction Proteins in Gastrointestinal Acute Radiation Syndrome Rats

[Journal Of Radiation Research] Researchers studied the therapeutic mechanism of Liangxue-Guyuan-Yishen decoction (LGYD) on gastrointestinal acute radiation syndrome (GI-ARS) and to provide a new scheme for the treatment of radiation injury. They investigated the effects of LGYD on intestinal stem cells in a GI-ARS rat model.

Autophagy in Colitis-Associated Colon Cancer: Exploring Its Potential Role in Reducing Initiation and Preventing IBD-Related CAC Development

[Autophagy] The authors summarize recent research on colitis-associated colon cancer (CAC) development and investigate the possible functions of autophagy in reducing CAC initiation.

OHSU Postdoc Receives Prestigious Award for Promising Early Career Scientists

[Oregon Health & Science University] Dr. Alexis Gibson, a Postdoctoral researcher at Oregon Health & Science University, is the recipient of a 2023 Howard Hughes Medical Institute, or HHMI, Hanna Gray Fellowship. The prestigious award recognizes talented early career scientists in the biomedical sciences.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.