Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

Chemotherapy-Induced Collagen IV Drives Cancer Cell Motility through Activation of Src and Focal Adhesion Kinase

[Cancer Research] Scientists showed that decellularized ECM (dECM) obtained from chemotherapy-treated mice increased motility of treatment-naïve breast cancer cells compared with vehicle-treated dECM.

An Injectable Gelatin/Sericin Hydrogel Loaded with Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Uterine Injury

[Bioengineering & Translational Medicine] A methacrylate gelatin and methacrylate sericin hydrogel with human umbilical cord mesenchymal stem cells encapsulation was designed for facilitating endometrial regeneration and fertility restoration through in situ injection.

ONOO−-Mediated Oxidative Modification of Extracellular Matrix Aggravates Atherosclerosis by Affecting Biological Behaviors of Vascular Smooth Muscle Cells

[Cell Biology International] Investigators studied the effect of oxidizing agent peroxynitrite-mediated oxidization of ECM proteins on the biological behaviors of vascular smooth muscle cells and the development of atherosclerosis.

A Basement Membrane Discovery Pipeline Uncovers Network Complexity, Regulators, and Human Disease Associations

[Science Advances] By developing a bioinformatic and in vivo discovery pipeline, researchers defined a network of 222 human proteins and their animal orthologs localized to basement membranes.

Topography-Induced Large-Scale Antiparallel Collective Migration in Vascular Endothelium

[Nature Communications] The authors showed that unconfined endothelial cell monolayers on microgroove substrates that mimic the anisotropic organization of the ECM exhibited a specific type of collective movement that took the form of a periodic pattern of antiparallel cell streams.

Laminin-Integrin a6b4 Interaction Activates Notch Signaling to Facilitate Bladder Cancer Development

[BMC Cancer] A 2D collagen/laminin culture system was established and CCK-8/transwell assay was conducted to evaluate the proliferation/migration ability of Biu-87 and MB49 cells cultured on 2D gels.

Synovial Mesenchymal Progenitor Derived Aggrecan Regulates Cartilage Homeostasis and Endogenous Repair Capacity

[Cell Death & Disease] Using mice models of osteoarthritis (OA) and cartilage repair, the authors demonstrated that intra-articular injection of aggrecan into OA joints inhibited cartilage degeneration and stimulated cartilage repair respectively.

A Biomimetic High Throughput Model of Cancer Cell Spheroid Dissemination onto Aligned Fibrillar Collagen

[Slas Technology] Scientists implemented a spheroid-based migration assay, integrated with a fibrillar type I collagen matrix, in a manner compatible with high throughput image acquisition and quantitative analysis.

Polymicrobial Biofilms Related to Dental Implant Diseases: Unravelling the Critical Role of Extracellular Biofilm Matrix

[Critical Reviews in Microbiology] Investigators discuss recent advances in the critical role of the extracellular polymeric substance matrix on biofilm growth and virulence on the dental implant surface and its effect on the etiopathogenesis and progression of implant-related infections.

In Utero Hypoxia Attenuated Acetylcholine-Mediated Vasodilatation via CHRM3/P-NOS3 in Fetal Sheep MCA: Role of ROS/ERK1/2

[Hypertension Research] Scientists investigated the effects and mechanisms of intrauterine hypoxia on fetal middle cerebral artery (MCA) vasodilatation.

IL-33 Enhances Jagged1 Mediated NOTCH1 Intracellular Domain (NICD) Deubiquitination and Pathological Angiogenesis in Proliferative Retinopathy

[Communications Biology] In vitro studies using human retinal microvascular endothelial cells showed that IL-33 induced sprouting angiogenesis and required NFkappaB-mediated Jagged1 expression and Notch1 activation.

Programmed Cell Death in Atherosclerosis and Vascular Calcification

[Cell Death & Disease] The authors review the molecular mechanisms that mediate cell death and its implications for atherosclerosis and vascular calcification.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.