Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

CCT6A Promotes Cell Proliferation in Colon Cancer by Targeting BIRC5 Associated with p53 Status

[Cancer Gene Therapy] Scientists reported that CCT subunit 6 A (CCT6A) silencing suppressed colon cancer proliferation and survival phenotype in vitro and in vivo. CCT6A played a role in cellular process, including the cell cycle, p53, and apoptosis signaling pathways.

Inhibition of DUSP18 Impairs Cholesterol Biosynthesis and Promotes Anti-Tumor Immunity in Colorectal Cancer

[Nature Communications] Scientists reported CRISPR screens in a mouse model of colorectal cancer (CRC) that implicated the dual specificity phosphatase 18 (DUSP18) in the establishment of tumor-directed immune evasion. Dusp18 inhibition reduced CRC growth rates, which correlated with high levels of CD8+ T cell activation.

Therapeutic Potential of the Secreted Kazal-Type Serine Protease Inhibitor SPINK4 in Colitis

[Nature Communications] Using single-cell sequencing to detect critical events in mucus dysfunction, researchers discovered that the Kazal-type serine protease inhibitor SPINK4 was dynamically regulated in colitic intestine in parallel with disease activities.

TRIM59 Deficiency Promotes M1 Macrophage Activation and Inhibits Colorectal Cancer through the STAT1 Signaling Pathway

[Scientific Reports] Researchers generated macrophage-specific tripartite motif 59 conditional knockout mice and utilized these mice to establish colitis-associated cancer and MC38 transplanted colorectal cancer (CRC) models for further investigation. The deficiency of TRIM59 in macrophages inhibited colorectal tumorigenesis in mice.

NUAK1 Activates STAT5/GLI1/SOX2 Signaling to Enhance Cancer Cell Expansion and Drives Chemoresistance in Gastric Cancer

[Cell Reports] Scientists investigated the mechanistic links among NUAK family kinase 1 (NUAK1), Hedgehog signaling, and tumorigenesis in gastric cancer. Patient-derived xenograft and transgenic mouse models demonstrated that NUAK1 depletion or inhibition dramatically ameliorated gastric tumorigenesis.

Harnessing the TP53INP1/TP53I3 Axis for Inhibition of Colorectal Cancer Cell Proliferation through MEG3 and Linc-ROR Co-expression

[Heliyon] Researchers assessed long intergenic non-coding RNA regulator of reprogramming silencing and maternally expressed gene 3 activation on the colorectal cancer cell proliferation simultaneously; and explored the underlying mechanisms in the TP53-associated Pathway.

Attenuated Replication and Damaging Effects of SARS-CoV-2 Omicron Variants in an Intestinal Epithelial Barrier Model

[Journal of Medical Virology] Researchers established an intestinal barrier model integrating epithelial Caco-2 cells, mucus-secreting HT29 cells, and Raji cells. This gut epithelial model allowed efficient differentiation of Caco-2 cells into microfold-like cells, faithfully mimicked intestinal barrier function, and was highly permissive to SARS-CoV-2 infection.

CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation

[Advanced Science] CircHIPK2 was a bona fide circular RNA consistently upregulated in both IBD and colorectal cancer (CRC). Silencing of circHIPK2 suppressed the growth of CRC cells in vitro and in vivo.

Merus Announces First Patient Dosed in Phase II Trial of Petosemtamab in 2L CRC

[Merus] Merus announced that the first patient has been dosed in the Company’s Phase II trial evaluating petosemtamab, a Biclonics® targeting EGFR and LGR5, in combination with standard chemotherapy in second line metastatic colorectal cancer.

Activation of Fetal-Like Molecular Programs during Regeneration in the Intestine and Beyond

[Cell Stem Cell] The authors summarize the molecular signals and epigenetic mediators that orchestrate “fetal-like reversion” during intestinal regeneration.

A Randomized Phase II Study of HLX22 plus Trastuzumab Biosimilar HLX02 and XELOX as First-Line Therapy for HER2-Positive Advanced Gastric Cancer

[Med] Patients with locally advanced/metastatic HER2-positive gastric/gastroesophageal junction cancer and no prior systemic antitumor therapy were randomized 1:1:1 to 25 mg/kg HLX22 + HLX02 + oxaliplatin and capecitabine, 15 mg/kg HLX22 + HLX02 + XELOX, or placebo + HLX02 + XELOX in 3-week cycles.

KLHL21 Suppresses Gastric Tumourigenesis via Maintaining STAT3 Signaling Equilibrium in Stomach Homoeostasis

[Gut] An integrated analysis of genes associated with metaplasia and dysplasia was conducted, verified and characterised in the gastric tissues of patients by single-cell RNA sequencing. Scientists generated multiple mouse models to investigate the role of Klhl21 deletion in stemness, DNA damage and tumor formation.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.

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