Intestinal Organoids in Co-Culture: Redefining the Boundaries of Gut Mucosa Ex Vivo Modeling

Organoid-derived intestinal co-culture models have established themselves as convenient tools to re-enact such pathophysiological events, explore interactions between selected cell populations and assess their roles with a central focus on intestinal barrier recovery and stabilization.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
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The Epithelial-Stromal Microenvironment in Early Colonic Neoplasia

Scientists analyzed molecular changes within the epithelial and stromal compartments of dysplastic aberrant crypt foci formed in the ascending colon, where rapidly developing interval cancers occur.
[Molecular Cancer Research]
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Mitochondrial Complex II in Intestinal Epithelial Cells Regulates T Cell-Mediated Immunopathology

Intestinal epithelial cell (IEC) damage by T cells contributes to graft-versus-host disease, inflammatory bowel disease and immune checkpoint blockade-mediated colitis. The relevance of IEC-intrinsic succinate dehydrogenase A in mediating disease severity was confirmed by complementary chemical and genetic experimental approaches and validated in human clinical samples.
[Nature Immunology]
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Bristol Myers Squibb Receives European Commission Approval for Opdivo (Nivolumab) + Chemotherapy for Patients with HER2 Negative, Advanced or Metastatic Gastric, Gastroesophageal Junction or Esophageal Adenocarcinoma

Bristol Myers Squibb announced that the European Commission (EC) has approved Opdivo (nivolumab) in combination with fluoropyrimidine- and platinum-based combination chemotherapy for the first-line treatment of adult patients with HER2-negative advanced or metastatic gastric, gastroesophageal junction (GEJ), or esophageal adenocarcinoma (EAC) whose tumors express PD-L1 with a combined positive score (CPS) ≥ 5.
[Bristol Myers Squibb]
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OLFM4-RET Fusion Is an Oncogenic Driver in Small Intestine Adenocarcinoma

Researchers investigated the biological effects of OLFM4-RET fusion and whether it could initiate tumorigenesis in small intestine.
[Oncogene]
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Everolimus and Plicamycin Specifically Target Chemoresistant Colorectal Cancer Cells of the CMS4 Subtype

Researchers reported the finding that two clinically employed agents, everolimus and plicamycin, efficiently target the prototypic CMS4 cell line MDST8.
[Cell Death & Disease]
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Novel Evidence for m6A Methylation Regulators as Prognostic Biomarkers and FTO as a Potential Therapeutic Target in Gastric Cancer

Researchers investigated the expression of the N6-methyladenosine (m6A) regulator genes and their prognostic potential in a large clinical cohort of 173 gastric cancer patients using qRT-PCR assays.
[British Journal of Cancer]
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Strategies for Genetic Manipulation of Adult Stem Cell-Derived Organoids

Scientists focus on adult gastrointestinal organoids and summarize the state-of-the-art protocols for successful transgenesis.
[Experimental & Molecular Medicine]
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Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids

The authors assessed induction of cystic fibrosis transmembrane conductance regulator (CFTR) function in premature termination codons-containing intestinal organoids using compounds targeting readthrough, nonsense mRNA mediated decay and CFTR protein modulation.
[Journal of Cystic Fibrosis]
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Antioxidant and Antiproliferative Potential of Ethanolic Extracts from Moringa oleifera, Tropaeolum tuberosum and Annona cherimola in Colorectal Cancer Cells

The extract of A. cherimola showed the highest antioxidant activity and M. oleifera had the highest capacity to enhance the activity of detoxifying enzymes such as glutathione S-transferase and quinone oxidoreductase.
[Biomedicine & Pharmacotherapy]
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Gastric Cancer Stem Cells Survive in Stress Environments via Their Autophagy System

Scientists clarified the significance of autophagy systems of CSCs under stress environments. Four gastric cancer cell line were used.
[Scientific Reports]
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