MIR17HG promoted glycolysis in colorectal cancer (CRC) cells and enhanced their invasion and liver metastasis in vitro and in vivo. Mechanistically, MIR17HG functioned as a ceRNA to regulate HK1 expression by sponging miR-138-5p, resulting in glycolysis in CRC cells and leading to their invasion and liver metastasis.
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Investigators showed the differentially expressed miRNAs in oxaliplatin-sensitive and oxaliplatin-resistant colorectal cancer cells through miRNA microarray technology and found that miR-135b-5p was significantly increased in oxaliplatin-resistant cells.
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Buried in a bill approved by the US Senate to help the United States compete with China is language that is drawing fire from human genome researchers. It would require the NIH to develop new security protocols aimed at preventing the misuse of US-funded genomic data by China and other nations.
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Researchers reported that asporin (ASPN) was upregulated in different stages of gastric cancer (GC), and associated with a poor prognosis, and found that ASPN markedly inhibited GC cell apoptosis and promoted cell growth in vitro and in vivo.
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Scientists found that acrolein induced oncogenic transformation, including faster cell cycling, proliferation, sphere formation and cell migration, in fibroblast cells, and acrolein-induced DNA damages were higher in colorectal cancer (CRC) tumor tissues than in normal epithelial cells in CRC patients.
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Researchers identified autophagy-related protein 9B (ATG9B) as a key potential target gene for colorectal cancer (CRC) metastasis, and found that ATG9B promoted CRC invasion mainly through autophagy-independent manner.
[Cell Death & Differentiation]
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Investigators showed that the pyroptosis-inducing fragment GSDME N-terminal was detected in the inflamed colonic mucosa but not in the uninflamed mucosa of patients with Crohn’s disease (CD), suggesting that GSDME-mediated pyroptosis may be correlated with intestinal mucosal inflammation in CD.
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The authors demonstrated that IL-6 activated autophagy through the IL-6/JAK2/BECN1 pathway and promoted chemotherapy resistance in colorectal cancer.
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Researchers employed a doxycycline-inducible phosphatase of regenerating liver-3 (PRL-3) mouse strain to show that aberrant PRL-3 expression within a non-cancerous background led to the death of Lgr5+ intestinal stem cells and to Paneth cell expansion.
[Journal of Molecular Medicine]
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Investigators showed that externalized phosphatidylserine (PS) was observed on the surface of colonic capillaries. Annexin A5 with high affinity for PS had a good targeting to the colon and effectively alleviated experimental colitis.
[Signal Transduction and Targeted Therapy]
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The authors determined that 14-3-3σ expression was significantly downregulated in primary human colorectal cancer when compared with adjacent normal colonic tissue in patient samples. Downregulation of 14-3-3σ in primary colorectal cancers was significantly associated with p53 mutation, increasing tumor stage, distant metastasis, and poor patient survival.
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