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Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
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E-Cadherin Loss in Cd44-Positive Gastric Cells Initiates Diffuse Gastric Cancer in a Murine Model
[Gut] Researchers aimed to develop mouse models of sporadic and hereditary DGC by inactivation of Cdh1 in the mouse stomach. They generated tamoxifen-inducible Cre/loxP mouse models of DGC driven by the Cd44 promoter with a tdTomato reporter.
Yap Mediates Hippo Signaling to Balance Proliferation and Differentiation in the Developing Glandular Stomach Epithelium
[Cell Reports] Scientists employed mouse genetics to reveal that Hippo signaling regulates stomach epithelial development by balancing epithelial proliferation and differentiation.
MLKL Confers Ferroptosis Resistance in Colorectal Cancer Cells via Impaired ESCRT-III-Mediated Membrane Repair
[Biology Direct] Researchers identified mixed lineage kinase domain-like protein (MLKL) as a key regulator of ferroptosis resistance in colorectal cancer, promoting tumor cell survival by coordinating antioxidant defenses and ESCRT-III–mediated membrane repair.
ENOX1 Promotes Gastric Cancer Progression via Snail2-Mediated Epithelial-Mesenchymal Transition and M2-Type Tumor-Associated Macrophages Polarisation
[International Immunopharmacology] Investigators identified ecto-nicotinamide adenine dinucleotide oxidase 1 (ENOX1) as a driver of gastric cancer progression, promoting epithelial–mesenchymal transition and M2 macrophage polarization through Snail2 signaling.
Synergistic Inhibition of Tumor Growth by MET and COX-2 Targeting in Gastric and Colorectal Cancers
[Bioorganic Chemistry] Scientists developed AspMet, a dual MET/COX-2 inhibitor that suppresses gastric and colorectal cancer growth by blocking oncogenic signaling, epithelial–mesenchymal transition, and angiogenesis.
S100A8 Lactylation at K23/K36 Reduces RNF5-Dependent Degradation and Promotes Colorectal Cancer Progression
[Biochemical and Biophysical Research Communications] Researchers showed that lactate-driven S100A8 lactylation stabilizes the protein by blocking RNF5-mediated degradation, promoting colorectal cancer progression.
Glycolysis‑Driven Immunosuppression in Gastric Cancer: Metabolic Crosstalk Between Tumor Cells and the Immune Microenvironment (Review)
[International Journal of Oncology] The authors summarize the molecular drivers of glycolytic reprogramming in gastric cancer, the mechanisms by which lactate‑centered crosstalk reshapes stromal and immune compartments, and emerging therapeutic strategies.
LTZ Therapeutics Announces FDA Clearance of IND Application for LTZ-232 to Treat Advanced Metastatic Colorectal Cancer and Other Solid Tumors
[LTZ Therapeutics] LTZ Therapeutics announced that the US FDA has cleared its Investigational New Drug (IND) application to evaluate LTZ-232 to treat patients with advanced metastatic colorectal cancer and other solid tumors.
Davidson Receives Distinguished Mentor Award
[Washington University in St. Louis] Nicholas O. Davidson, MD, DSc, the John E. and Adaline Simon Professor of Medicine and chief of the Division of Gastroenterology at WashU Medicine, has been named the recipient of the 2026 Distinguished Mentor Award from the American Gastroenterological Association.
Lineage Plasticity Driven by GATA6 Loss Fuels Colorectal Cancer Metastasis
[Cell Stem Cell] Researchers showed that loss of GATA6 drives lineage plasticity and fuels colorectal cancer liver metastasis by activating fetal-like and basal-like transcriptional programs.
Fusobacterium periodonticum Promotes Colorectal Tumorigenesis via Decanoic Acid-Driven Neutrophil Chemotaxis
[Nature Communications] Scientists showed, through metagenomic and metabolomic analyses of clinical cohorts, that Fusobacterium periodonticum is significantly enriched in colorectal cancer patients and strongly correlated with elevated decanoic acid levels.
Restoring O-Glycosylation and Expression of MUC2 Limits Progression of Colorectal Cancer
[Cell Death & Disease] The authors investigated the regulatory pathway controlling MUC2 expression and O-glycosylation in colorectal cancer and assessed the therapeutic potential of rosiglitazone in restoring mucosal integrity.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
