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Intestinal Cell News is an online resource that curates the latest research using intestinal cells.
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Oncogenic snoRNA SNORD78 Fuels Colorectal Cancer by Protecting the m6a Reader IMP2 to Enhance Phospholipid Metabolism
[Proceedings of the National Academy of Sciences of the United States of America] The authors systematically deciphered the precise interaction mechanism between SNORD78 and the m6A reader IMP2 in colorectal cancer.
DCAF13: A Positive Regulator of Colon Cancer Cell Proliferation via the AMER2/ Wnt/β-Catenin Pathway
[NPJ Precision Oncology] As one of the Cullin RING Ligase 4 adapters, DNA damage-binding protein 1 - and CUL4 correlation factor 13 (DCAF13) appeared strongly expressed in different tumors. Scientists' findings confirm enhanced expression of DCAF13 in tissues of colorectal cance origin and related cell.
Matrix Stiffness Promotes Colorectal Cancer Progression via Golgi-Dependent Cholesterol Synthesis
[Cell Death & Disease] Researchers showed that extracellular matrix stiffness drives colorectal cancer progression by activating Piezo1-dependent cholesterol synthesis.
The Beclin1‑Targeting Stapled Peptide Suppresses Colorectal Cancer Progression by Disrupting EGFR/β-Catenin Axis
[Journal of Translational Medicine] Investigators uncovered a previously uncharacterized Beclin1-dependent EGFR/β-catenin regulatory cascade in colorectal cancer.
METTL1 Facilitates Colorectal Cancer Progression through Internal M7g Methylation of MACC1 and SDCCAG8 mRNA
[Biology Direct] Scientists found methyltransferase-like protein-1 (METTL1), the key m7G methyltransferase, is highly expressed in colorectal cancer tissues via whole-transcriptome sequencing, qRT-PCR and immunohistochemical analysis.
ZNF695 Promotes Colorectal Cancer Progression through Transcriptional Activation of CBX8 and Subsequent Wnt/β-Catenin Signaling Activation
[Molecular Carcinogenesis] To assess the impact of zinc finger protein 695 (ZNF695) on colorectal cancer tumor progression, the authors generated a xenograft model utilizing nude mice.
Precision Prime Editing of TP53 Mutations for Functional Tumor Suppression in Colorectal Cancer
[Biochemical and Biophysical Research Communications] Investigators aim to discuss the future potential of prime editing as a new generation of genome engineering to identify precise approaches to correct TP53 mutations in colorectal cancer.
ASCP Announces Recipients of Novel Quality Improvement Grant to Advance Biomarker Testing and Precision Care in Metastatic Colorectal Cancer
[The American Society for Clinical Pathology] The American Society for Clinical Pathology (ASCP), in collaboration with Pfizer and with participation from the American Society of Clinical Oncology, announced the recipients of its metastatic colorectal cancer Quality Improvement Grant Program.
E-Cadherin Loss in Cd44-Positive Gastric Cells Initiates Diffuse Gastric Cancer in a Murine Model
[Gut] Researchers aimed to develop mouse models of sporadic and hereditary DGC by inactivation of Cdh1 in the mouse stomach. They generated tamoxifen-inducible Cre/loxP mouse models of DGC driven by the Cd44 promoter with a tdTomato reporter.
Yap Mediates Hippo Signaling to Balance Proliferation and Differentiation in the Developing Glandular Stomach Epithelium
[Cell Reports] Scientists employed mouse genetics to reveal that Hippo signaling regulates stomach epithelial development by balancing epithelial proliferation and differentiation.
MLKL Confers Ferroptosis Resistance in Colorectal Cancer Cells via Impaired ESCRT-III-Mediated Membrane Repair
[Biology Direct] Researchers identified mixed lineage kinase domain-like protein (MLKL) as a key regulator of ferroptosis resistance in colorectal cancer, promoting tumor cell survival by coordinating antioxidant defenses and ESCRT-III–mediated membrane repair.
ENOX1 Promotes Gastric Cancer Progression via Snail2-Mediated Epithelial-Mesenchymal Transition and M2-Type Tumor-Associated Macrophages Polarisation
[International Immunopharmacology] Investigators identified ecto-nicotinamide adenine dinucleotide oxidase 1 (ENOX1) as a driver of gastric cancer progression, promoting epithelial–mesenchymal transition and M2 macrophage polarization through Snail2 signaling.
Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.
