By reviewing the different biological and molecular aspects of neuroblastoma and anti-GD2 antibodies (GD2-IMT), the author questions the present lack of association between GD2-IMT and the underlying molecular landscape.
To generate spatially-resolved tumor and immune cell data at single cell resolution, investigators developed two quantitative multiplex immunofluorescence assays to interrogate myeloid cells and macrophages in the pancreatic ductal carcinoma tumor microenvironment.
[Clinical Cancer Research]
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Väyrynen, S. A., Zhang, J., Yuan, C., Väyrynen, J. P., Costa, A. D., Williams, H., Morales-Oyarvide, V., Lau, M. C., Rubinson, D. A., Dunne, R. F., Kozak, M. M., Wang, W., Agostini-Vulaj, D., Drage, M. G., Brais, L. K., Reilly, E., Rahma, O. E., Clancy, T. E., Wang, J., … Wolpin, B. M. (2020). Composition, spatial characteristics, and prognostic significance of myeloid cell infiltration in pancreatic cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3141 Cite
Calidi Biotherapeutics, Inc. announced that it has been granted a new patent from the European Patent Office (EPO). “Combination Immunotherapy Approach for Treatment of Cancer,” secures Calidi’s proprietary technology platform, Supernova 1, composed of the oncolytic agent, CAL1 vaccinia virus, loaded into allogeneic, adipose-derived MSCs.
[Calidi Biotherapeutics, Inc.]
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The authors showed that in preclinical autoimmunity and established systemic lupus erythematosus, plasmacytoid dendritic cells were not effector cells, had lost capacity for Toll-like-receptor-mediated cytokine production and did not induce T cell activation.
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Psarras, A., Alase, A., Antanaviciute, A., Carr, I. M., Md Yusof, M. Y., Wittmann, M., Emery, P., Tsokos, G. C., & Vital, E. M. (2020). Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity. Nature Communications, 11(1), 6149. https://doi.org/10.1038/s41467-020-19918-z Cite
Food insecurity was associated with increased activation of CD4+ and CD8+ T-cells, increased senescence of CD8+ T-cells, and decreased co-stimulation of CD4+ and CD8+ T-cells
[Clinical Infectious Diseases]
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Peters, B. A., Sheira, L. A., Hanna, D. B., Qi, Q., Sharma, A., Adedimeji, A., Wilson, T., Merenstein, D., Tien, P. C., Cohen, M., Wentz, E. L., Kinslow, J., Landay, A. L., & Weiser, S. D. (n.d.). Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa1771 Cite
Researchers recapitulated the immunosuppression observed in glioblastoma patients in the C57BL/6 mouse and investigated the aetiology of low CD4 T-cell counts.
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Ayasoufi, K., Pfaller, C. K., Evgin, L., Khadka, R. H., Tritz, Z. P., Goddery, E. N., Fain, C. E., Yokanovich, L. T., Himes, B. T., Jin, F., Zheng, J., Schuelke, M. R., Hansen, M. J., Tung, W., Parney, I. F., Pease, L. R., Vile, R. G., & Johnson, A. J. (n.d.). Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators. Brain. https://doi.org/10.1093/brain/awaa343 Cite
To clarify the role of CD4+ regulatory T cells in bladder cancer, scientists investigated the frequency of these cells in tumor draining lymph nodes of 50 patients with bladder cancer who underwent radical cystectomy using flow cytometry method.
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Riddell’s lab is working to make CAR T-cell therapies even better and expand the repertoire of cancers it can treat. Based out of the Hutch’s new Steam Plant facility, he and his colleagues are zeroing in on multiple myeloma as the next likely new target for the approach.
[Fred Hutchinson Cancer Research Center]
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Scientists showed that Linezolid, a ribosomal-targeting antibiotic (RAbo), effectively blocked the course of a T cell-mediated autoimmune disease.
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Almeida, L., Dhillon-LaBrooy, A., Castro, C. N., Adossa, N., Carriche, G. M., Guderian, M., Lippens, S., Dennerlein, S., Hesse, C., Lambrecht, B. N., Berod, L., Schauser, L., Blazar, B. R., Kalesse, M., Müller, R., Moita, L. F., & Sparwasser, T. (2020). Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.11.001 Cite
Researchers describe a novel function of tumor-associated myeloid cells related to the enhanced breakdown of extracellular hyaluronan (HA) in human bladder cancer tissue, leading to the accumulation of small HA fragments with MW <20 kDa.
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Scientists discovered that hepatic B cell lymphopoiesis did not cease after birth and that tolerance defects contributed to immunoglobulin G-autoantibody accumulation in biliary atresia.
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Wang, J., Xu, Y., Chen, Z., Liang, J., Lin, Z., Liang, H., Xu, Y., Wu, Q., Guo, X., Nie, J., Lu, B., Huang, B., Xian, H., Wang, X., Wu, Q., Zeng, J., Chai, C., Zhang, M., Lin, Y., … Zhang, Y. (2020). Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.10.048 Cite