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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
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RegCell Secures $66 Million of Additional Funding to Bring Nobel-Winning Immune Tolerance Science to the Clinic
[RegCell, Inc. (Businesswire)] RegCell, Inc. announced a grant from Japan’s Agency for Medical Research and Development. The funding will advance RegCell’s epigenetic reprogramming platform, built on Nobel Laureate and RegCell co-founder Dr. Shimon Sakaguchi’s discovery of Tregs into clinical-stage development.
Santa Ana Bio Announces First Subjects Dosed in Phase I Study of SAB01 to Treat Autoimmune Inflammatory Diseases
[Santa Ana Bio] Santa Ana Bio announced that the first cohort has been dosed in the first-in-human Phase I study of SAB01, a novel bispecific antibody designed to selectively deplete mast cells through co-engagement of KIT and Siglec-6.
UCLA Researchers Receive NIH Grant to Launch Trial for Immunotherapy-Related Diabetes
[UCLA Health] UCLA researchers have received a grant worth up to $7 million over five years from the National Institute of Allergy and Infectious Diseases to launch a first-in-human clinical trial evaluating whether drugs already used to treat autoimmune diseases can prevent or reverse immune checkpoint inhibitor-induced type 1 diabetes.
Pilot Grant Supports New Research in Understanding of Endometriosis
[UC San Diego Today] The inaugural Women’s Health Innovation Cross-Disciplinary Pilot Grant is bringing together faculty from the University of California (UC) San Diego School and the La Jolla Institute for Immunology to investigate the role of the immune system in endometriosis.
A Bispecific CD3×CD19 Antibody for Systemic Lupus Erythematosus: A Phase I Trial
[Nature Medicine] Scientists reported results from the intravenous treatment arm of an ongoing, first-in-disease, Phase I trial of A-319, a next-generation CD3×CD19 TCE, in 12 patients with active systemic lupus erythematosus with 52 weeks of follow-up.
Spatiotemporal Single-Cell Profiling Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-Versus-Host Disease
[Nature Immunology] Scientists studied 31 transplant recipients, integrating longitudinal T cell antigen receptor (TCR) profiling with single-cell RNA sequencing/TCR sequencing and spatial transcriptomics to track T cell clonal dynamics.
The FAP × CD3 Bispecific Antibody OMTX305 Induces T Cell-Mediated Antitumor Effects in Patient-Derived Ex Vivo Models of Solid Tumors
[Science Advances] Researchers developed a bispecific, trivalent fragment engineered immunoglobulin T cell engager (OMTX305) targeting fibroblast activation protein (FAP), a marker of tumor-promoting cancer-associated fibroblasts.
Single-Cell Profiling Links T Cell Accumulation and TH2/TH17 Dynamics to Eosinophilic Esophagitis (EoE) Activity in Children
[Allergy] To investigate the functional role of non-eosinophilic immune cells, researchers examined immune cell infiltrate over the disease course in pediatric patients with eosinophilic esophagitis (EoE) and performed single-cell molecular analysis of the T-cell infiltrate.
Transcriptomic Profiling of Immune Cells in Malignant Pleural Effusions Identifies Macrophage Reprogramming Associated with Survival
[JCI Insight] Investigators performed single cell analysis with flow cytometry validation of CD45+ cells in eight malignant and five benign pleural fluid specimens to identify changes in the transcriptomic landscape of immune cells across disease states.
Gut Microbiota Functional Remodeling and Butyrate Depletion Amplify Anti-Ro/La Antibody-Driven Type I Interferon Activation in Neonatal Lupus
[Gut Microbes] Scientists investigated whether gut microbial functional capacity and metabolites influence autoantibody-dependent immune activation in 90 neonates, including healthy controls, anti-Ro/La-exposed neonates without neonatal lupus erythematosus, and neonates with neonatal lupus erythematosus.
TREM2⁺ Tumor-Associated Macrophages in Cancer: Context-Dependent Biology, Biomarkers, and Precision Immunotherapy
[Critical Reviews in Oncology/Hematology] The authors provide a critical and translational synthesis of triggering receptor expressed on myeloid cells 2 (TREM2)-associated macrophage biology in cancer. They examine the molecular basis of TREM2 ligand recognition and signaling, followed by its roles in macrophage functional heterogeneity ans immune evasion.
Mechanisms of Resistance to BTK Inhibitors in B Cell Malignancies and Emerging Targeted Strategies
[Molecular Therapy Oncology] Scientists provide a comprehensive overview of the mechanisms driving Bruton tyrosine kinase (BTK) inhibitors resistance and discuss current preclinical and clinical strategies aimed at improving therapeutic outcomes in B cell malignancies.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
