Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Pioneering Engineer-Researcher to Receive 2022 Szent-Györgyi Prize for Progress in Cancer Research

[National Foundation for Cancer Research] The National Foundation for Cancer Research (NFCR) announced today that Dr. Rakesh K. Jain has been selected to receive the 2022 Szent-Györgyi Prize for Progress in Cancer Research.

The Systemic Anti-Microbiota IgG Repertoire Can Identify Gut Bacteria That Translocate across Gut Barrier Surfaces

[Science Translational Medicine] The authors presented a modified high-throughput, culture-independent approach to quantify systemic immunoglobulin G (IgG) against gut commensal bacteria in human serum samples without the need for paired stool samples.

LACC1 Bridges NOS2 and Polyamine Metabolism in Inflammatory Macrophages

[Nature] Scientists elucidated a shared biochemical function of laccase domain-containing 1 (LACC1) in mice and humans, converting L-citrulline to L-ornithine and isocyanic acid and serving as a bridge between proinflammatory nitric oxide synthase (NOS2) and polyamine immunometabolism.

Transcription-Independent Regulation of STING Activation and Innate Immune Responses by IRF8 in Monocytes

[Nature Communications] Investigators showed that interferon regulatory factor 8 (IRF8) was essential for efficient activation of STING-mediated innate immune responses in monocytes.

The Evolving Role of Tissue-Resident Memory T Cells in Infections and Cancer

[Science Advances] Investigators provide a concise review of the development and physiological role of CD8+ resident memory T cells, their involvement in diseases, and their potential therapeutic exploitation.

The UK Is Getting a New Prime Minister — What Will It Mean for Science?

[Nature] The race to decide who will become the new leader of the UK Conservative Party, and the country’s next Prime Minister, has less than a month left to run.

NexImmune Sizes Up the Competition and Decides to Pause Myeloma T Cell Therapy Plans

[Fierce Biotech] Turns out NexImmune is not resistant to the tough competition in multiple myeloma. The company cited the competitive environment in the blood cancer space as reason for pausing enrollment on one of its two clinical candidates.

Single Cell Spatial Analysis Reveals the Topology of Immunomodulatory Purinergic Signaling in Glioblastoma

[Nature Communications] The authors revealed that purinergic signaling in gliomas was shaped by genotype, lineage, and functional state, and that core enzymes expressed by tumor and myeloid cells were organized to promote adenosine-rich microenvironments potentially amenable to therapeutic targeting.

Treatment of Allergic Eosinophilic Asthma through Engineered IL-5-Anchored Chimeric Antigen Receptor T Cells

[Cell Discovery] Researchers engineered a cytokine-anchored CAR T cell system using a chimeric IL-5-CD28-CD3ζ receptor to trigger T-cell-mediated killing of eosinophils that were elevated during severe asthma attacks.

Western Researchers Attract More than $7.6M in Federal Funding

[Western University] Research to help improve memory in children with intellectual disabilities is one of several Western research projects receiving more than $7.6 million in funding from the Canadian Institutes of Health Research.

Single-Cell ATAC-Seq Maps the Comprehensive and Dynamic Chromatin Accessibility Landscape of CAR-T Cell Dysfunction

[Leukemia] The authors initially observed that CAR-T cells showed rapid differentiation and increased exhaustion after co-culture with tumor cells in vitro, and then performed single-cell ATAC-seq to depict the comprehensive and dynamic landscape of chromatin accessibility of CAR-T cells during tumor cell stimulation.

Individualized, Heterologous Chimpanzee Adenovirus and Self-Amplifying mRNA Neoantigen Vaccine for Advanced Metastatic Solid Tumors: Phase I Trial Interim Results

[Nature Medicine] Safety, tolerability, and recommended Phase II dose of an individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA-based neoantigen vaccine in combination with nivolumab and ipilimumab were assessed as primary endpoints in an ongoing Phase I/II study in patients with advanced metastatic solid tumors.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.

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