FDA Grants Priority Review and EMA Accepts Regulatory Submission for Pfizer’s Abrocitinib, an Oral Once-Daily JAK1 Inhibitor, for Patients 12 and Up with Moderate to Severe Atopic Dermatitis

Pfizer Inc. announced that the FDA accepted for filing and granted Priority Review designation to the company’s New Drug Application for abrocitini, an investigational oral once-daily Janus kinase 1 inhibitor, for the treatment of moderate to severe atopic dermatitis in patients 12 and older.
[Pfizer Inc. (BusinessWire, Inc.)]
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Trans-Hit Biomarkers Announces Today a Partnership with Nexelis, Supporting Sample Procurement Activities for a Number of Strategic Projects Including COVID-19 Vaccines and Immuno-oncology Development Initiatives

Trans-Hit Biomarkers Inc. announced the signing of a partnership agreement with Laboratoires Nexelis Canada Inc. to support prophylactic and therapeutic vaccine development programs sponsored by global pharmaceutical companies, innovative biotechnology companies, and prestigious governmental and non-governmental organizations including Bill and Melinda Gates Foundation and Coalition for Epidemic Preparedness Innovations.
[Trans-Hit Biomarkers, Inc.]
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Apellis and Sobi Enter Collaboration for Global Co-development and Ex-US Commercialization of Systemic Pegcetacoplan in Rare Diseases with Urgent Need for New Treatments

Apellis Pharmaceuticals, Inc. and Swedish Orphan Biovitrum AB announced a strategic collaboration to accelerate the advancement of systemic pegcetacoplan, a targeted C3 therapy, for the treatment of multiple rare diseases with high unmet need that impact more than 275,000 patients globally.
[Apellis Pharmaceuticals, Inc.]
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Multimodal Mapping of the Tumor and Peripheral Blood Immune Landscape in Human Pancreatic Cancer

Using a combination of CyTOF, single-cell RNA sequencing and multiplex immunohistochemistry on patient tumors, matched blood and non-malignant samples, scientists uncovered a complex network of immune-suppressive cellular interactions.
[Nature Cancer]
Steele, N. G., Carpenter, E. S., Kemp, S. B., Sirihorachai, V. R., The, S., Delrosario, L., Lazarus, J., Amir, E. D., Gunchick, V., Espinoza, C., Bell, S., Harris, L., Lima, F., Irizarry-Negron, V., Paglia, D., Macchia, J., Chu, A. K. Y., Schofield, H., Wamsteker, E.-J., … Pasca di Magliano, M. (2020). Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer. Nature Cancer, 1–16. https://doi.org/10.1038/s43018-020-00121-4 Cite
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Gene Expression Analysis in Formalin Fixed Paraffin Embedded Melanomas Is Associated with Density of Corresponding Immune Cells in Those Tissues

[Scientific Reports]
Gene expression analysis in formalin fixed paraffin embedded melanomas is associated with density of corresponding immune cells in those tissues | Scientific Reports. (n.d.). Retrieved October 27, 2020, from https://www.nature.com/articles/s41598-020-74996-9 Cite
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Arcutis Completes Enrollment in Phase I/IIb Study Evaluating ARQ-252 in Chronic Hand Eczema

Arcutis Biotherapeutics, Inc. completed enrollment in its Phase I/IIb study of ARQ-252, a potent and highly selective topical small molecule inhibitor of Janus kinase type 1, in adult patients with chronic hand eczema. Arcutis updated its projections and now anticipates announcing topline data from this trial by mid-2021.
[Arcutis Biotherapeutics, Inc.]
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Irreversible Electroporation Plus Allogenic Vγ9Vδ2 T Cells Enhances Antitumor Effect for Locally Advanced Pancreatic Cancer Patien

Researchers investigated the antitumor efficacy of irreversible electroporation plus allogeneic γδ T cells in locally advanced pancreatic cancer patients.
[Signal Transduction and Targeted Therapy]
Lin, M., Zhang, X., Liang, S., Luo, H., Alnaggar, M., Liu, A., Yin, Z., Chen, J., Niu, L., & Jiang, Y. (2020). Irreversible electroporation plus allogenic Vγ9Vδ2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients. Signal Transduction and Targeted Therapy, 5(1), 1–9. https://doi.org/10.1038/s41392-020-00260-1 Cite
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T Cell Regeneration after Immunological Injury

The authors focus on the causes and consequences of impaired adaptive immunity and discuss therapeutic strategies that can recover immune function, with a particular emphasis on approaches that can promote a diverse repertoire of T cells through de novo T cell formation.
[Nature Reviews Immunology]
Velardi, E., Tsai, J. J., & van den Brink, M. R. M. (2020). T cell regeneration after immunological injury. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-020-00457-z Cite
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Quantitative PCR Methodology With a Volume-Based Unit for the Sophisticated Cellular Kinetic Evaluation of Chimeric Antigen Receptor T Cells

Researchers established a novel qPCR methodology incorporating a spike-in calibration curve that expressed cellular kinetics in units of copies/μL blood, as is the case for conventional pharmacokinetic studies of small molecules and other biologics.
[Scientific Reports]
Yamamoto, S., Matsumoto, S., Goto, A., Ugajin, M., Nakayama, M., Moriya, Y., & Hirabayashi, H. (2020). Quantitative PCR methodology with a volume-based unit for the sophisticated cellular kinetic evaluation of chimeric antigen receptor T cells. Scientific Reports, 10(1), 17884. https://doi.org/10.1038/s41598-020-74927-8 Cite
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HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis

Scientists characterized the immunopeptidomes of the two HLA-DR15 allomorphs DR2a and DR2b of human primary B cells and monocytes, thymus, and multiple sclerosis brain tissue.
[Cell]
Wang, J., Jelcic, I., Mühlenbruch, L., Haunerdinger, V., Toussaint, N. C., Zhao, Y., Cruciani, C., Faigle, W., Naghavian, R., Foege, M., Binder, T. M. C., Eiermann, T., Opitz, L., Fuentes-Font, L., Reynolds, R., Kwok, W. W., Nguyen, J. T., Lee, J.-H., Lutterotti, A., … Martin, R. (2020). HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.09.054 Cite
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Early-Onset Autoimmunity Associated with SOCS1 Haploinsufficiency

By whole-exome/genome sequencing scientists identified heterozygous, autosomal-dominant, germline loss-of-function mutations in the SOCS1 gene in ten patients from five unrelated families with early onset autoimmune manifestations.
[Nature Communications]
Hadjadj, J., Castro, C. N., Tusseau, M., Stolzenberg, M.-C., Mazerolles, F., Aladjidi, N., Armstrong, M., Ashrafian, H., Cutcutache, I., Ebetsberger-Dachs, G., Elliott, K. S., Durieu, I., Fabien, N., Fusaro, M., Heeg, M., Schmitt, Y., Bras, M., Knight, J. C., Lega, J.-C., … Rieux-Laucat, F. (2020). Early-onset autoimmunity associated with SOCS1 haploinsufficiency. Nature Communications, 11(1), 5341. https://doi.org/10.1038/s41467-020-18925-4 Cite
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