Investigators report that physiologically relevant oxygen concentration, an important environmental thymic factor promotes differentiation of cord blood CD34+ cells into progenitor T cells in serum‐free and feeder‐free culture system.
Investigators utilized the complementary approaches of T cell receptor sequencing and cytometry by time-of-flight analysis to obtain a peripheral immune signature of responsiveness to PD-1 blockade in 56 patients treated in the CheckMate 205 Phase II clinical trial
6445212 JFKZ8XKD items 1 apa default asc 1
Cader, F. Z., Hu, X., Goh, W. L., Wienand, K., Ouyang, J., Mandato, E., Redd, R., Lawton, L. N., Chen, P.-H., Weirather, J. L., Schackmann, R. C. J., Li, B., Ma, W., Armand, P., Rodig, S. J., Neuberg, D., Liu, X. S., & Shipp, M. A. (2020). A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma. Nature Medicine, 1–12. https://doi.org/10.1038/s41591-020-1006-1 Cite
Investigators propose a new vaccine platform that enhances all three arms of the adaptive immune system to improve tumor‐associated antigens‐based cancer vaccination in hepatocellular carcinoma patients.
6445212 4D5JNRR7 items 1 apa default asc 1
Lu, L., Jiang, J., Zhan, M., Zhang, H., Wang, Q.-T., Sun, S.-N., Guo, X.-K., Yin, H., Wei, Y., Li, S.-Y., Liu, J. O., Li, Y., & He, Y.-W. (n.d.). Targeting Tumor-Associated Antigens in Hepatocellular Carcinoma for Immunotherapy: Past Pitfalls and Future Strategies. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31502 Cite
Data sets revealed that B cells in the blood were not in homeostasis with compartments in other tissues. Investigators found striking donor-to-donor variability in the frequencies and isotype of CD27+ memory B cells
6445212 5R6BUP4V items 1 apa default asc 1
The authors believe that currently available strategies for vaccines that target dendritic cells or use them to present antitumour antigens could be integrated into existing clinical practice using prime–boost approaches.
[Nature Reviews Drug Discovery]
Investigators established anti-AQP4 recombinant autoantibodies from plasmablasts in neuromyelitis optica spectrum disorder patient’s cereberospinal fluid.
Investigators report here that IL-17A mRNA and protein were detectable in some human triple-negative breast cancer cell lines and further upregulated by IL-23 and LPS stimulation.
6445212 PE7DFFXH items 1 apa default asc 1
Dawod, B., Liu, J., Gebremeskel, S., Yan, C., Sappong, A., Johnston, B., Hoskin, D. W., Marshall, J. S., & Wang, J. (2020). Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas. Scientific Reports, 10(1), 13343. https://doi.org/10.1038/s41598-020-70231-7 Cite
Researchers chronically exposed patient-derived melanoma cell lines to differentiation antigen-specific cytotoxic T cells and observed strong enrichment of a pre-existing NGFRhi population.
6445212 SLZMP765 items 1 apa default asc 1
Boshuizen, J., Vredevoogd, D. W., Krijgsman, O., Ligtenberg, M. A., Blankenstein, S., de Bruijn, B., Frederick, D. T., Kenski, J. C. N., Parren, M., Brüggemann, M., Madu, M. F., Rozeman, E. A., Song, J.-Y., Horlings, H. M., Blank, C. U., van Akkooi, A. C. J., Flaherty, K. T., Boland, G. M., & Peeper, D. S. (2020). Reversal of pre-existing NGFR-driven tumor and immune therapy resistance. Nature Communications, 11(1), 3946. https://doi.org/10.1038/s41467-020-17739-8 Cite
To identify glucocorticoid resistance pathways, investigators conducted a genome-wide, survival-based, shRNA screen in murine T cell acute lymphoblastic leukemia cells.
6445212 VIPY2KCW items 1 apa default asc 1
Roderick, J. E., Gallagher, K. M., Murphy, L. C., O’Connor, K. W., Tang, K., Zhang, B., Brehm, M., Greiner, D. L., Yu, J., Zhu, L. J., Green, M. R., & Kelliher, M. A. (n.d.). Prostaglandin E2 stimulates cAMP signaling and re-sensitizes human leukemia cells to glucocorticoid-induced cell death. Blood. https://doi.org/10.1182/blood.2020005712 Cite
Scientists report that Eph receptor A5 (EPHA5) mutations were associated with increased tumor mutation burden, neoantigen load, levels of immune-related gene expression signatures, and enhanced tumor-infiltrating lymphocytes in lung adenocarcinoma.
[Cancer Gene Therapy]
6445212 VQASNW6G items 1 apa default asc 1
Developmental stages were distinguished by 2,823 signature chromatin regions with 95% accuracy. Open chromatin surrounding SAE 1 was identified to best distinguish thymic developmental stages suggesting a potential role of SUMO ylation in T‐cell development.
[EMBO Molecular Medicine]
6445212 UMNSUT3V items 1 apa default asc 1
Erarslan-Uysal, B., Kunz, J. B., Rausch, T., Richter-Pechańska, P., van Belzen, I. A., Frismantas, V., Bornhauser, B., Ordoñez-Rueada, D., Paulsen, M., Benes, V., Stanulla, M., Schrappe, M., Cario, G., Escherich, G., Bakharevich, K., Kirschner-Schwabe, R., Eckert, C., Loukanov, T., Gorenflo, M., … Kulozik, A. E. (2020). Chromatin accessibility landscape of pediatric T-lymphoblastic leukemia and human T-cell precursors. EMBO Molecular Medicine, n/a(n/a), e12104. https://doi.org/10.15252/emmm.202012104 Cite
Understanding the precise immunological mechanisms that underlie the efficacy of chemotherapy has the potential not only to enable the identification of superior biomarkers of response but also to accelerate the development of synergistic combination regimens that enhance the clinical effectiveness of immune checkpoint inhibitors relative to their effectiveness as monotherapies.
[Nature Reviews Clinical Oncology]