Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

A Human Autoimmune Organoid Model Reveals IL-7 Function in Celiac Disease

July 25, 2024

[Nature] Scientists generated air–liquid interface duodenal organoids from intact fragments of endoscopic biopsies that preserved epithelium alongside native mesenchyme and tissue-resident immune cells as a unit without requiring reconstitution.

Detection and Characterization of Autoreactive Memory Stem T-Cells in Children with Acute Immune Thrombocytopenia

July 25, 2024

The authors investigated the role of different memory T cell subsets, including T stem cell memory, in children diagnosed with primary primary immune thrombocytopenia...

Systemic and Skin-Limited Delayed-Type Drug Hypersensitivity Reactions Associate with Distinct Resident and Recruited T Cell Subsets

July 24, 2024

[Journal of Clinical Investigation] The authors leveraged recent technical advancements to study skin-resident memory T cells (TRM) versus recruited T cell subsets in the pathogenesis of severe systemic forms of disease, SJS/TEN and DRESS, and skin-limited disease, morbilliform drug eruption

AURKB Promotes Immunogenicity and Immune Infiltration in Clear Cell Renal Cell Carcinoma

July 23, 2024

[Discover Oncology] Expression profiles and relevant clinical annotations were retrieved from the Cancer Genome Atlas and UCSC Xena platform for progression-free survival data. The R package "limma" was used to identify differentially expressed chromatin regulators.

Novel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing

July 23, 2024

[Circulation] Single-cell sequencing in peripheral blood mononuclear cells revealed a novel human-specific long noncoding RNA called HEAT4 (heart failure–associated transcript 4). HEAT4 expression was assessed in several in vitro and ex vivo models of immune cell activation, as well as in the blood of patients with heart failure, acute myocardial infarction, or cardiogenic shock.

ATM Inhibition Enhance Immunotherapy by Activating STING Signaling and Augmenting MHC Class I

July 23, 2024

[Cell Death & Disease] Investigators found that either gene knockout or drug intervention, ataxia telangiectasia mutated (ATM) inhibition activated the cGAS/STING pathway and augmented MHC class I in CRC cells, and these effects could be amplified by radiation.

Organelle Phenotyping and Multi-Dimensional Microscopy Identify C1q as a Novel Regulator of Microglial Function

July 23, 2024

[Journal of Neurochemistry] The authors proposed a novel organelle phenotyping approach in whichscientists treated live human induced pluripotent stem cell-derived microglia with organelle dyes staining mitochondria, lipids, lysosomes and acquire data by live-cell spectral microscopy.

Novel Insights Into Paclitaxel’s Role on Tumor-Associated Macrophages in Enhancing PD-1 Blockade in Breast Cancer Treatment

July 23, 2024

[Journal For Immunotherapy of Cancer] Scientists employed an integrated approach, analyzing spatial transcriptomics and single-cell RNA sequencing data from TNBC patients to understand why the combination of PTX and PD-1 blockade showed better response in triple-negative breast cancerpatients.

Single-Cell Chromatin Accessibility and Transposable Element Landscapes Reveal Shared Features of Tissue-Residing Immune Cells

July 23, 2024

[Immunity] Investigators analyzed single-cell chromatin accessibility data, including the transposable element (TE) landscape of CD45+ immune cells from colon, skin, adipose tissue, and spleen.

The Recruitment of CD8+ T Cells Ttrough YBX1 Stabilization Abrogates Tumor Intrinsic Oncogenic Role of MIR155HG in Lung Adenocarcinoma

July 23, 2024

[Cell Death Discovery] Scientists observed a positive correlation between MIR155HG expression and overall survival across different cohorts. The transferred PBMC on the NCG mouse model abrogated the tumor intrinsic oncogenic role of MIR155HG in lung adenocarcinoma.

PARK7/DJ-1 Deficiency Impairs Microglial Activation in Response to LPS-Induced Inflammation

July 23, 2024

[Journal of Neuroinflammation] Using a combination of single-cell RNA-sequencing, bulk RNA-sequencing, multicolor flow cytometry and immunofluorescence analyses, we comprehensively compared microglial cell phenotypic characteristics in PARK7/DJ-1 knock-out with wildtype littermate mice following 6- or 24-hours intraperitoneal injection with lipopolysaccharide.

Tocilizumab and CytoSorb for Delayed Severe Cytokine Release Syndrome After Ipilimumab Plus Nivolumab Immunotherapy

July 23, 2024

[Immunotherapy] Researchers present a case of delayed grade 4 cytokine release syndrome following treatment of lung adenocarcinoma with ipilimumab plus nivolumab that warranted intensive care level treatment with abundant fluid resuscitation, two-tire vasopressor support, high-flow nasal oxygenation, corticosteroids in high dosages, as well as sustained low-efficiency daily diafiltration with CytoSorb hemadsorption and tocilizumab.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.