Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

OMRF Scientist Awarded $3.4 Million to Investigate Immune Cells

[Oklahoma Medical Research Foundation] The National Institutes of Health recently awarded Dr. Xiao-Hong Sun a $3.4 million grant to continue unraveling mysteries about innate lymphoid cells, including whether they may offer clues about the differences in immune reactions between children and adults.

CPT1A Induction following Epigenetic Perturbation Promotes MAVS Palmitoylation and Activation to Potentiate Antitumor Immunity

[Molecular Cell] Scientists showed that mitochondrial CPT1A downregulation following viral infection restrained, while its induction by epigenetic perturbations sustained, a double-stranded RNA-activated IFN-I response.

The USP7-STAT3-Granzyme-Par-1 Axis Regulates Allergic Inflammation by Promoting Differentiation of IL-5-Producing Th2 Cells

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors found that granzyme A- and B-producing Th2 cells played a key role in the promotion of pathogenic Th2 cells via protease-activated receptor (Par)-1 and induced the phosphorylation of p38 mitogen-activated protein kinase.

Most Clinical Trials Run in Canada Failed to Take Basic Steps Toward Transparency, Analysis Finds

[STAT News] Just 3% of more than 3,700 studies run exclusively in Canada over a recent 10-year period were registered prospectively, reported results, and published the findings, underscoring ongoing concerns about clinical trial transparency, according to a new analysis.

GRP78-CAR T Cell Effector Function against Solid and Brain Tumors Is Controlled by GRP78 Expression on T Cells

[Cell Reports Medicine] The authors showed that glucose-regulated protein 78 (GRP78) was highly expressed on the cell surface of multiple solid and brain tumors, making cell surface GRP78 a promising chimeric antigen receptor (CAR) T cell target.

AIM/CD5L Ameliorates Autoimmune Arthritis by Promoting Removal of Inflammatory DAMPs at the Lesions

[Journal of Autoimmunity] Investigators showed that apoptosis inhibitor of macrophage (AIM) protein regulated arthritis by promoting removal of lesional danger-associated molecular patterns (DAMPs) both physiologically and therapeutically.

PRMT1 Inhibition Activates the Interferon Pathway to Potentiate Antitumor Immunity and Enhance Checkpoint Blockade Efficacy in Melanoma

[Cancer Research] Researchers found that protein arginine methyl transferase 1 (PRMT1) expression was inversely correlated with the number and activity of CD8+ T cells within melanoma specimen.

Circulating T Follicular Helper 2 Cells, T Follicular Regulatory Cells, and Regulatory B Cells Are Effective Biomarkers for Predicting the Response to House Dust...

[Frontiers in Immunology] Scientists performed house dust mite sublingual immunotherapy for 20 patients with atopic asthma comorbid with allergic rhinitis who were already receiving ordinary treatments including inhaled corticosteroid.

CD8+ Treg Cells Play a Role in the Obesity-Associated Insulin Resistance

[Life Sciences] Investigators characterized the CD8+ Treg cells in human peripheral blood and adipose tissue, specifically, to address the effect of obesity and insulin resistance in this regulatory immune cell population.

The Immunometabolic Ecosystem in Cancer

[Nature Immunology] Scientists examine the metabolic interplay between tumor-resident cells and how targeted inhibition of specific metabolic enzymes in malignant cells could elicit pro-tumorigenic effects in non-transformed tumor-resident cells and inhibit the function of tumor-specific T cells.

IVI, KAIST to Collaborate in Global Vaccine Research to Accelerate Innovations in Vaccines and Immunology

[International Vaccine Institute] The International Vaccine Institute (IVI) and the Korea Advanced Institute of Science and Technology (KAIST) signed a memorandum of understanding for global vaccine research collaboration.

CAR+ and CAR− T Cells Share a Differentiation Trajectory into an NK-Like Subset after CD19 CAR T Cell Infusion in Patients with B Cell...

[Nature Communications] Investigators conducted a single-cell multi-omics analysis of transcriptional, clonal, and phenotypic profiles from pre- to one-month post-infusion of CAR+ and CAR T cells from patients from a CARTELL study who received a donor-derived 4-1BB CAR product targeting CD19.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.