Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Recent Advances and Challenges of Cellular Immunotherapies in Lung Cancer Treatment
[Experimental Hematology & Oncology] The authors highlight recent advances and challenges in the use of cellular immunotherapies for the treatment of lung cancer, which might stimulate new ideas for the further development of cellular immunotherapies.
Rescuing Dendritic Cell Interstitial Motility Sustains Antitumor Immunity
[Nature] Through longitudinal analysis of human and mouse tumours, researchers observed a progressive decrease in migratory conventional dendritic cells in the tdLNs during tumor progression.
MAVS Signaling of Long-Lived Brain-Resident Myeloid Cells Is Needed During Viral Encephalitis to Adjust the Transcriptome of CNSÂ Infiltrating CD8+T Cells
[Journal of Neuroinflammation] Scientists used mice with conditional deletions of the mitochondrial antiviral-signaling protein, an adaptor for RIG-I-like receptor signaling.
Multi-GWAS Analysis Illuminates Druggable Targets for Rheumatoid Arthritis
[Postgraduate Medical Journal] Researchers identified effective drug target genes to reduce rheumatoid arthritis (RA) risk through the multi-genome-wide association studies analysis.
Combretastatin A4-Based Albumin Nanoparticles Remodeling the Tumor Immune Microenvironment to Enhance T Cell Immunotherapy in Colon Cancer
[ACS Nano] Investigators indicated that CA4@Alb effectively reprograms the immunosuppressive microenvironment of colon cancer, holding promising translational potential for enhancing immunotherapy efficacy.
Human Milk IgA Promotes Normal Immune Development by Limiting Th17-Inducing Erysipelatoclostridium ramosum in the Infant Gut
[Proceedings of the National Academy of Sciences of the United States of America] Researchers characterize the microbiota reactivity of human milk secretory IgA (SIgA), demonstrating relationships between maternal SIgA and infant gut microbiota composition.
CD4+T Cells License Kupffer Cells to Reverse CD8+T Cell Dysfunction Induced by Hepatocellular Priming
[Nature Immunology] Investigators generated hepatitis B virus-specific CD4+ T cell receptor transgenic mice to show that CD4+ effector T cells can prevent and reverse the CD8+ T cell dysfunction induced by hepatocellular priming.
The Prostacyclin Receptor PTGIR Is a NRF2-Dependent Regulator of CD8+T Cell Exhaustion
[Nature Immunology] Scientists identified PTGIR as an NRF2-dependent immune checkpoint that regulates the balance between effector and exhausted CD8+ T cell states.
Glioma Promotes Macrophage Immunosuppressive Phenotype Through ANXA1 in a Methionine Metabolism-Dependent Manner
[Discover Oncology] Researchers investigated the feature of methionine metabolism in gliomas and its relationship with the tumor immune microenvironment. They observed a significant positive correlation between methionine metabolism activity scoring-score and glioma WHO grades.
Impact of Tumor-Infiltrating Immune Cells Expressing PD-1 and Those Expressing PD-L1 on Recurrence and Prognosis in Pathological T1b Clear Cell Renal Cell Carcinoma
[Japanese Journal of Clinical Oncology] Investigators suggested that PD-ligand 1 (PD-1)-positive tumor-infiltrating immune cells score of the tumor nest and tumor necrosis may efficiently predict recurrence in pT1b clear cell renal cell carcinoma.
Advancing CAR-Based Cell Therapies for Solid Tumours: Challenges, Therapeutic Strategies, and Perspectives
[Molecular Cancer] Scientists explore the challenges of CAR-based cellular therapies in solid tumours and highlights emerging strategies to overcome therapeutic limitations.
The Entrenchment of NLRP3 Inflammasomes in Autoimmune Disease-Related Inflammation
[Autoimmunity Reviews] The authors provide a comprehensive overview on NLRP3 inflammasome contribution into the pathogenesis of some autoimmune diseases.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
