Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Rare SH2B3 Coding Variants in Lupus Patients Impair B Cell Tolerance and Predispose to Autoimmunity

[Journal Of Experimental Medicine] The authors showed that unlike the variant found exclusively in healthy controls, SH2B3 rare variants found in lupus patients are predominantly hypomorphic alleles, failing to suppress IFNGR signaling via JAK2-STAT1.

Iron Dysregulation and Inflammatory Stress Erythropoiesis Associates with Long-Term Outcome of COVID-19

[Nature Immunology] Researchers assessed 214 individuals infected with SARS-CoV-2, with varying disease severity, for one year from COVID-19 symptom onset to determine the early correlates of post-acute sequelae.

Anti-TIGIT Antibody Improves PD-L1 Blockade through Myeloid and Treg Cells

[Nature] Investigators found that a high baseline of intratumoural macrophages and regulatory T cells was associated with better outcomes in patients treated with atezolizumab plus tiragolumab but not with atezolizumab alone.

An Immunosuppressive Vascular Niche Drives Macrophage Polarization and Immunotherapy Resistance in Glioblastoma

[Science Advances] Scientists identify a distinct mesenchymal-like population of endothelial cells that form an immunosuppressive vascular niche in glioblastoma.

A Functional Identification Platform Reveals Frequent, Spontaneous Neoantigen-Specific T Cell Responses in Patients with Cancer

[Science Translational Medicine] Researchers developed a platform that combined bioinformatic analysis of tumor exomes and transcriptional data with functional testing of autologous peripheral blood mononuclear cells to simultaneously identify and validate neoantigens recognized by naturally primed CD4+ and CD8+ T cell responses.

Identification of a Leucine-Mediated Threshold Effect Governing Macrophage mTOR Signaling and Cardiovascular Risk

[Nature Metabolism] In a series of clinical studies on male and female participants that involved graded amounts of protein ingestion together with detailed plasma amino acid analysis and human monocyte/macrophage experiments, researchers identified leucine as the key activator of mTOR signaling in macrophages.

Enhancing Chimeric Antigen Receptor T Cell Therapy by Modulating the p53 Signaling Network with Δ133p53α

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers showed that constitutive expression of Δ133p53α potentiated the anti-tumor activity of CD19-directed CAR T cells and limits dysfunction under conditions of high tumor burden and metabolic stress.

Bulk RNA Sequencing Reveals the Comprehensive Genetic Characteristics of Human Cord Blood-Derived Natural Killer Cells

[Regenerative Therapy] Frozen T cell-free cord blood mononuclear cells were cultured with recombinant human interleukin (rhIL)-18 and rhIL-2 in anti-NKp46 and anti-CD16 antibody immobilization settings.

Cytokine and Soluble Programmed Death-Ligand 1 Levels in Serum and Plasma of Cancer Patients Treated with Immunotherapy: Preanalytical and Analytical Considerations

[International Journal Of Biological Markers] Three Luminex xMAP assays and two ELLA microfluidic cartridges were used to screen 28 immune-related biomarkers in 38 paired serum and citrate-theophylline-adenosine-dipyridamole plasma samples.

A Novel Gain-of-Function STAT3 Variant in Infantile-Onset Diabetes Associated with Multiorgan Autoimmunity

[Molecular Genetics & Genomic Medicine] The authors described a Chinese patient with infantile-onset diabetes and multiorgan autoimmunity. The patient presented with early-onset type 1 diabetes and autoimmune hypothyroidism at seven months.

Empowering Pancreatic Tumor Homing with Augmented Anti-Tumor Potency of CXCR2-Tethered CAR-NK Cells

[Molecular Therapy Oncology] Pancreatic cancer cells were found to secrete high levels of ligands for C-X-C motif receptor 1 (CXCR1) and CXCR2. Subsequently, the authors generated anti-mesothelin CAR-NK cells incorporating CXCR1 or CXCR2 and evaluated their tumor-killing abilities in 2D cancer cell co-culture and 3D tumor-mimetic organoid models.

PD-L1-Expressing Tumor-Associated Macrophages Are Immunostimulatory and Associate with Good Clinical Outcome in Human Breast Cancer

[Cell Reports Medicine] Using single-cell transcriptomic and spatial multiplex immunofluorescence analyses, scientists showed that PD-L1+ tumor-associated macrophages were mature and immunostimulatory with spatial preference to T cells.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.

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