Innate Immunity at the Crossroads of Healthy Brain Maturation and Neurodevelopmental Disorders

The authors discuss the essential roles of microglia and innate immune signaling in the assembly and maintenance of a properly functioning nervous system.
[Nature Reviews Immunology]
Zengeler, K. E., & Lukens, J. R. (2021). Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-020-00487-7 Cite
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Impedimetric Microfluidic Sensor‐in‐a‐Tube for Label‐Free Immune Cell Analysis

An innovative rolled‐up impedimetric microfulidic sensor, called sensor‐in‐a‐tube, was introduced for the simultaneous analysis of single human monocytes CD14+ and their extracellular medium upon liposaccharides‐mediated activation.
[Small]
Egunov, A. I., Dou, Z., Karnaushenko, D. D., Hebenstreit, F., Kretschmann, N., Akgün, K., Ziemssen, T., Karnaushenko, D., Medina‐Sánchez, M., & Schmidt, O. G. (n.d.). Impedimetric Microfluidic Sensor-in-a-Tube for Label-Free Immune Cell Analysis. Small, n/a(n/a), 2002549. https://doi.org/https://doi.org/10.1002/smll.202002549 Cite
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A Bispecific Single Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses towards CD1d in Chronic Lymphocytic Leukemia

Scientists evaluated CD1d expression in a cohort of 78 untreated CLL patients and generated a CD1d-specific Vγ9Vδ2-T cell engager based on single-domain antibodies.
[Clinical Cancer Research]
Weerdt, I. de, Lameris, R., Ruben, J. M., Boer, R. de, Kloosterman, J., King, L. A., Levin, M.-D., Parren, P. W. H. I., Gruijl, T. D. de, Kater, A. P., & Vliet, H. J. van der. (2021). A bispecific single domain antibody boosts autologous Vγ9Vδ2-T cell responses towards CD1d in chronic lymphocytic leukemia. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-4576 Cite
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Personalized Neoantigen Pulsed Dendritic Cell Vaccine for Advanced Lung Cancer

Scientists attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous dendritic cell vaccine and conducted a single-arm, 2 medical centers, pilot study initiated by the investigator.
[Signal Transduction and Targeted Therapy]
Ding, Z., Li, Q., Zhang, R., Xie, L., Shu, Y., Gao, S., Wang, P., Su, X., Qin, Y., Wang, Y., Fang, J., Zhu, Z., Xia, X., Wei, G., Wang, H., Qian, H., Guo, X., Gao, Z., Wang, Y., … Yang, L. (2021). Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer. Signal Transduction and Targeted Therapy, 6(1), 1–12. https://doi.org/10.1038/s41392-020-00448-5 Cite
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Perfect Adaptation of CD8+ T Cell Responses to Constant Antigen Input Over a Wide Range of Affinities Is Overcome by Costimulation

Researchers observed that in vitro–expanded primary human T cells exhibited perfect adaptation with respect to cytokine production to constant antigen stimulation across a 100,000-fold variation in affinity with partial T cell receptors down-regulation.
[Science Signaling]
Trendel, N., Kruger, P., Gaglione, S., Nguyen, J., Pettmann, J., Sontag, E. D., & Dushek, O. (2021). Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation. Science Signaling, 14(666). https://doi.org/10.1126/scisignal.aay9363 Cite
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Characterization of Ascites- and Tumor-Infiltrating γδ T Cells Reveals Distinct Repertoires and a Beneficial Role in Ovarian Cancer

The authors demonstrated that tumor-infiltrating γδ T cells isolated from patients with ovarian cancer have distinct T cell receptors and exhibit more innate-like functions compared to blood- or ascites-derived γδ T cells.
[Science Translational Medicine]
Foord, E., Arruda, L. C. M., Gaballa, A., Klynning, C., & Uhlin, M. (2021). Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer. Science Translational Medicine, 13(577). https://doi.org/10.1126/scitranslmed.abb0192 Cite
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Personal Neoantigen Vaccines Induce Persistent Memory T Cell Responses and Epitope Spreading in Patients with Melanoma

Scientists evaluated the clinical outcome and circulating immune responses of eight patients with surgically resected stage IIIB/C or IVM1a/b melanoma,
[Nature Medicine]
Hu, Z., Leet, D. E., Allesøe, R. L., Oliveira, G., Li, S., Luoma, A. M., Liu, J., Forman, J., Huang, T., Iorgulescu, J. B., Holden, R., Sarkizova, S., Gohil, S. H., Redd, R. A., Sun, J., Elagina, L., Giobbie-Hurder, A., Zhang, W., Peter, L., … Ott, P. A. (2021). Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma. Nature Medicine, 1–11. https://doi.org/10.1038/s41591-020-01206-4 Cite
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Nanoparticle T-Cell Engagers as a Modular Platform for Cancer Immunotherapy

Scientists developed nanoparticle-based bispecific T-cell engagers, which were liposomes decorated with anti-CD3 monoclonal antibodies (mAbs) targeting T cells, and mAbs targeting the cancer antigen.
[Leukemia]
Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy | Leukemia. (n.d.). Retrieved January 22, 2021, from https://www.nature.com/articles/s41375-021-01127-2 Cite
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HLA Class I Loss in Colorectal Cancer: Implications for Immune Escape and Immunotherapy

Investigators summarize the prevalence and molecular mechanisms behind HLA-I loss in colorectal cancer (CRC), and discuss HLA-I expression/loss in the context of the newly identified CRC molecular subtypes.
[Cellular & Molecular Immunology]
Anderson, P., Aptsiauri, N., Ruiz-Cabello, F., & Garrido, F. (2021). HLA class I loss in colorectal cancer: implications for immune escape and immunotherapy. Cellular & Molecular Immunology, 1–10. https://doi.org/10.1038/s41423-021-00634-7 Cite
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Tumor-Associated Myeloid Cells: Diversity and Therapeutic Targeting

Scientists provide an overview of the recent literature on the ever-growing complexity of the biology of tumor-associated macrophages and tumor-associated neutrophils and the development of the most promising approaches to target these populations therapeutically in cancer patients.
[Cellular & Molecular Immunology]
Mantovani, A., Marchesi, F., Jaillon, S., Garlanda, C., & Allavena, P. (2021). Tumor-associated myeloid cells: diversity and therapeutic targeting. Cellular & Molecular Immunology, 1–13. https://doi.org/10.1038/s41423-020-00613-4 Cite
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Innate Immunity at the Crossroads of Healthy Brain Maturation and Neurodevelopmental Disorders

The authors discuss the essential roles of microglia and innate immune signaling in the assembly and maintenance of a properly functioning nervous system.
[Nature Reviews Immunology]
Zengeler, K. E., & Lukens, J. R. (2021). Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-020-00487-7 Cite
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