Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Novel Tri-Specific T Cell Engager Targeting IL-13Rα2 and EGFRvIII Provides Long-Term Survival in Heterogeneous GBM Challenge and Promotes Antitumor Cytotoxicity with Patient Immune Cells
Researchers described novel trivalent antibodies, DNA-encoded tri-specific T cell engagers, targeting two glioblastoma multiforme antigens, epidermal growth factor receptor variant III (EGFRvIII) and IL-13Rα2,...
Efficacy and Safety of Switching to Daily Bictegravir Plus Lenacapavir From a Complex Human Immunodeficiency Virus Treatment Regimen: A Randomized, Open-Label, Multicenter Phase II...
ARTISTRY-1 is a Phase II/III, operationally seamless, randomized, open-label, multicenter, active-controlled study. Phase II of the study enrolled adults with plasma HIV-1 RNA 50...
Cutaneous T Cell Lymphoma Atlas Reveals Malignant TH2 Cells Supported by a B Cell-Rich Tumor Microenvironment
Investigators performed single-cell and spatial transcriptomics analysis of skin from patients with mycosis fungoides-type cutaneous T cell lymphoma and an integrated comparative analysis with...
Integrated Single-Cell Transcriptome and TCR Profiles of Hepatocellular Carcinoma Highlight the Convergence on Interferon Signaling During Immunotherapy
[Journal For Immunotherapy of Cancer] Scientists comprehensively analyzed paired single-cell RNA transcriptome and T cell repertoire profiles from 14 hepatocellular carcinoma ascites samples, collected from 7 patients before and after treatment with the combination of sintilimab and bevacizumab.
Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma
[American Journal of Respiratory and Critical Care Medicine] Researchers determined the frequency and within-patient variability of corticosteroid-responsive type 1 (T1)-high, T2-high, and T1/T2-high asthma endotypes and whether virally influenced T1-high disease influences corticosteroid response in asthma.
Long-Term Follow Up in Anti-Contactin-1 Autoimmune Nodopathy
[Annals of Neurology] Scientists analyzed long-term clinical and biomarker features of anti-contactin-1 autoimmune nodopathy. Patients with anti-CNTN1+ autoimmune nodopathy detected in our laboratory from which clinical information was available were included.
In Human CD4+ T-Cells, Omeprazole Suppresses Proliferation, Downregulates V-ATPase, and Promotes Differentiation Toward an Autoimmunity-Favoring Phenotype
[International Immunopharmacology] Triggered by findings indicating a correlation between proton pump inhibitors usage and susceptibility to infectious or autoimmune diseases, investigators studied the impact of a pharmacological concentration of omeprazole on human CD4+ T cells.
Rheumatoid Arthritis: A Review of the Key Clinical Features and Ongoing Challenges of the Disease
[Panminerva Medica] The authors provide a comprehensive overview of rheumatoid arthritis, covering new research on the ‘pre-clinical’ phase of the disease, as well as its epidemiology, pathogenesis, clinical manifestations, diagnosis, imaging, and management strategies.
Moffitt Patient Is First To Receive Second CAR T Therapy for Ovarian Cancer
[Moffitt Cancer Center] Marisol Gallagher, with Drs. Robert Wenham and Monica Avila, received a second round of CAR T-cell therapy 18 months after her first round. Her care team hopes the second infusion will cure her ovarian cancer once and for all.
Safety and Activity of CTX130, a CD70-Targeted Allogeneic CRISPR-Cas9-Engineered CAR T-Cell Therapy, in Patients with Relapsed or Refractory T-Cell Malignancies (COBALT-LYM): A Single-Arm, Open-Label,...
[Lancet Oncology] Researchers assessed the safety and activity of CTX130, a CD70-directed, allogeneic CAR immunotherapy manufactured from healthy donor T cells, in patients with relapsed or refractory T cell lymphoma.
Assessing Human B Cell Responses to Influenza Virus Vaccines and Adjuvants in a PBMC-Derived In Vitro Culture System
[Vaccine] Investigators assessed whether B cells present in peripheral blood mononuclear cells responded to vaccines and reflected the effects of different vaccine formulations and adjuvants.
Dominant Negative Variants in ITPR3 Impair T Cell Ca2+ Dynamics Causing Combined Immunodeficiency
[Journal of Experimental Medicine] The importance of calcium as a second messenger in T cell signaling was exemplified by genetic deficiencies of STIM1 and ORAI1, which abolished store-operated calcium entry resulting in combined immunodeficiency.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
