Cancer Stem Cell News
Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Subscribe|Follow Us On
Fall Grants Roundup
[Weill Cornell Medicine] Weill Cornell Medicine has received major new funding to support collaborative research spanning clinical trials, precision medicine and drug target discovery with the potential to improve outcomes for patients with challenging cancers.
United Immunity Announces Master Clinical Supply Agreement with Roche to Evaluate UI-102 in Combination with an Anti–PD-L1 Therapy in Advanced Solid Tumors
[United Immunity, Co. ] United Immunity, Co. announced that it has entered into a Master Clinical Supply Agreement with Roche for the supply of atezolizumab, a humanized anti-PD-L1 monoclonal antibody checkpoint inhibitor. The agreement will support future clinical studies evaluating UI-102, a TLR7/8 agonist encapsulated in a pullulan nanoparticle, in combination with atezolizumab.
Temporal Dynamics of the Immune Response to Neoadjuvant Androgen Deprivation Therapy Suggest a Window of Opportunity for Checkpoint Inhibitor Therapy in Prostate Cancer
[Journal for Immunotherapy of Cancer] Investigators analyzed transcriptomic profiles, imputed immune-cell content, and spatially identified immune-cell phenotypes and temporal changes in surgical specimens from a cohort of men treated with neoadjuvant androgen deprivation therapy prior to prostatectomy.
Alternative Splicing of CD244 Restrains Natural Killer Cells at the Maternal-Fetal Interface
[Mucosal Immunology] Reearchers showed that first-trimester decidual natural killer cells reside in a stable non-cycling state characterized by G0/G1 arrest, suppression of proliferation-associated transcriptional programs, and attenuated kinase signaling.
Immunometabolic Profiling of T Cells and Innate Lymphoid Cells Uncovers Therapeutic Targets to Enhance Immunotherapy in Head and Neck Cancer
[Cancer Immunology Research] Using functional-metabolic flow cytometry, the authors characterized tumor-infiltrating mucosal-associated invariant T cells, CD8+ T cells, and innate lymphoid cells from head and neck squamous cell carcinoma patients receiving neoadjuvant anti–PD-1 monotherapy or combined anti–PD-1/anti–IL-8 therapy.
Comparative Clinical Outcomes and Single-Cell Profiling of CD19 CAR-T Versus Blinatumomab for Relapsed/Refractory B-ALL
[Journal for Immunotherapy of Cancer] Scientists performed a comprehensive study to compare the efficacy and safety of CD19 CAR-T versus blinatumomab therapy for patients with refractory/relapsed B-acute lymphoblastic leukemia. They erformed scRNA-seq on patient-derived CAR-T/blinatumomab-elicited T cells after therapy, and conducted a head-to-head comparison in vitro.
Peripheral Blood as the Sole Source for Cancer Neoantigen and Reactive T-Cell Discovery
[Cancer Discovery] Investigators proposed a novel strategy relying solely on peripheral blood to identify non-synonymous mutations via cell-free DNA whole-exome sequencing and isolate neoantigen-specific CD4+ and CD8+ T cells based on PD-1 and CD39 co-expression.
A Human Single-Cell Atlas Identifies OLR1 Scar-Associated Macrophages As a Potential Therapeutic Target for Chronic Liver Disease
[Nature Genetics] The authors generated a liver single-cell atlas comprising 649,295 cells from 42 healthy and 35 Chronic liver disease patients, identifying 125 transcriptionally distinct cellular states. They resolvd two types of disease-expanded TREM2+ scar-associated macrophages.
Tumor-Infiltrating B Cells in Cancer Immunity: Heterogeneity, Spatial Organization, and Context-Dependent Function
[Critical Reviews in Oncology/Hematology] Scientists propose that B cells support anti-tumor immunity when integrated into organized lymphoid niches and engaged in productive T cell–B cell cooperation, whereas they promote immune escape when redirected toward regulatory programs or suppressive myeloid interactions.
Single-Cell RNA Sequencing Reveals the Interaction of TREM2 Macrophages and Tc17 Lymphocytes in Scalp Psoriasis
[Immunologic Research] Researchers performed single-cell RNA sequencing on CD45⁺ immune cells isolated from scalp and body plaque lesions of patients with psoriasis. TREM2⁺ macrophages in scalp lesions displayed elevated inflammatory and antigen-presentation signatures, including increased MHC-I expression.
Myeloid Infiltration and Epidermal Dysregulation Characterize Cutaneous Photosensitivity in Systemic Lupus Erythematosus
[Science Translational Medicine] Scientists used cutaneous ultraviolet (UV) B photoexposure of healthy controls and patients with systemic lupus erythematosus to provide an atlas of the cutaneous inflammatory response 24 hours after UV exposure in single-cell resolution.
RegCell Secures $66 Million of Additional Funding to Bring Nobel-Winning Immune Tolerance Science to the Clinic
[RegCell, Inc. (Businesswire)] RegCell, Inc. announced a grant from Japan’s Agency for Medical Research and Development. The funding will advance RegCell’s epigenetic reprogramming platform, built on Nobel Laureate and RegCell co-founder Dr. Shimon Sakaguchi’s discovery of Tregs into clinical-stage development.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
