Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Acasti Pharma Announces Positive Results for Pharmacokinetic Bridging Study, with Intravenous GTX-104 Meeting All Endpoints

[Acasti Pharma Inc.] Acasti Pharma Inc. announced that the top line results of its pharmacokinetic bridging study with IV GTX-104, the Company’s lead drug candidate for the treatment of Subarachnoid Hemorrhage , met all its planned study endpoints.

Adaptive Immune Defense Prevents Bartonella Persistence upon Trans-placental Transmission

[PLoS Pathogens] Researchers studied an experimental model of Bartonella infection in mice to assess the impact of maternal and newborn immune defense on vertical transmission and bacterial persistence in the offspring, respectively.

Autophagic Flux Inhibition, Apoptosis, and Mitochondrial Dysfunction in Bile Acids-Induced Impairment of Human Placental Trophoblast

[Journal of Cellular Physiology] Researchers evaluated the effect of increased concentration of bile acids on autophagy in trophoblasts in vitro and in vivo.

Aberrant Hypomethylation at Imprinted Differentially Methylated Regions Is Involved in Biparental Placental Mesenchymal Dysplasia

[Clinical Epigenetics] Scientists examined 44 placental specimens from 26 patients with PMD: 19 of these were macroscopically normal and 25 exhibited macroscopic PMD.

SRT1720 Plays a Role in Oxidative Stress and the Senescence of Human Trophoblast HTR8/SVneo Cells Induced by D-galactose through the SIRT1/FOXO3a/ROS Signaling Pathway

[Reproductive Toxicology] Scientists evaluated the effects of D-gal on HTR8/SVneo cells and the mechanisms in vitro. The activity of HTR8/SVneo human trophoblasts decreased in a time- and concentration-dependent manner after exposure to D-gal.

Expression Profiles of Circular RNA in Human Placental Villus and Decidua and Prediction of Drugs for Recurrent Spontaneous Abortion

[American Journal of Reproductive Immunology] Scientists evaluated potential biomarkers and candidate drugs for recurrent spontaneous abortion (RSA) and explored functional circular RNA pathways involved in regulating RSA.

Effect of Umbilical Cord Mesenchymal Stem Cell Transplantation under LIFPUS Pretreatment on Thyroid Function in EAT Rats

[Current Stem Cell Research & Therapy] Scientists showed that LIFPUS could effectively stimulate hUCMSCs in vitro to achieve the most optimal proliferative and secretory activity.

Allogenic Umbilical Cord Blood-Mesenchymal Stem Cells Are More Effective than Antibiotics in Alleviating Subclinical Mastitis in Dairy Cows

[Theriogenology] Researchers isolated, in vitro cultured, and characterized the umbilical cord-derived mesenchymal stem cells (UCB-MSCs) as well as UCB-MSC-extracellular vesicles.

WNT and NOTCH Signaling in Human Trophoblast Development and Differentiation

[Cellular and Molecular Life Sciences] Research discuss Wingless (WNT) and NOTCH signaling, two pathways that play pivotal roles in human placenta and trophoblast development.

Anonymous $11 Million Gift to Support and Expand Neurofibromatosis Research at UHN’s Krembil Brain Institute

[University Health Network (Newswise, Inc.)] University Health Network (UHN) Foundation announced an anonymous gift of $11 million in support of neurofibromatosis research.

C2N Diagnostics Introduces P-tau Multi-Analyte Assay for Research Use Only to Advance Alzheimer’s Disease and Brain Health Field

[C2N Diagnostics (Business Wire)] C2N Diagnostics announced its latest innovative offering for enhancing care in brain health: a high-resolution mass spectrometry-based plasma tau multi-analyte assay (p-tau MAA) for Research Use Only.

Myotubularin-Related Phosphatase 5 Is a Critical Determinant of Autophagy in Neurons

[Current Biology] Scientists sampled nascent transcript synthesis and stabilities in fibroblasts, induced pluripotent stem cells (iPSCs), and iPSC-derived neurons, thereby uncovering a neuron-specific stability of transcripts encoding myotubularin-related phosphatase 5.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.