Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

The Local Microenvironment Drives Activation of Neutrophils in Human Brain Tumors

[Cell] The authors investigated neutrophils in tumor tissue of glioma and brain metastasis patients, with matched peripheral blood, and described the first in-depth analysis of neutrophil phenotypes and functions in these tissues.

The Pancreatic Cancer Action Network Selects Oncolytics Biotech® Inc. to Receive $5 Million Therapeutic Accelerator Award to Develop Leading-Edge Treatments

[Oncolytics Biotech Inc.] The $5 million grant will enable Oncolytics to continue the next stage of its research focused on a clinical trial with Oncolytics' proprietary reovirus pelareorep in combination with modified FOLFIRINOX chemotherapy, with or without an immune checkpoint inhibitor.

LAPIX Therapeutics Inc. Announces FDA Clearance of IND Application for Its Treg-Expanding Tim3/4 Agonist LPX-TI641 to Treat Multiple Sclerosis

[LAPIX Therapeutics, Inc.] APIX Therapeutics, Inc. announced that it has received clearance of its Investigational New Drug (IND) application from the US FDA to initiate a Phase I clinical trial for its first-in-class, immune tolerance restoration small molecule, LPX-TI641, for the treatment of multiple sclerosis.

Mitochondria-ER Contact Mediated by MFN2-SERCA2 Interaction Supports CD8+ T Cell Metabolic Fitness and Function in Tumors

[Science Immunology] The authors showed that mitofusin-2 (MFN2) expression was positively correlated with the prognosis of multiple cancers. Genetic ablation of Mfn2 in CD8+ T cells dampened mitochondrial metabolism and function and promoted tumor progression.

CREB1-Driven CXCR4hi Neutrophils Promote Skin Inflammation in Mouse Models and Human Patients

[Nature Communications] Investigators demonstrated that CXCR4hi neutrophils accumulated in the blood and inflamed skin in human psoriasis, and correlated with disease severity.

Regulation of Human and Mouse Bystander T Cell Activation Responses by PD-1

[JCI Insight] Scientists observed that Programmed Cell Death Protein 1 (PD-1)+ T cells demonstrated less activation and proliferation than activated PD-1– populations in vitro.

Acute Myeloid Leukemia-Derived Exosomes Deliver miR-24-3p to Hinder the T Cell Immune Response through DENN/MADD Targeting in the NF-κB Signaling Pathways

[Cell Communication and Signaling] Investigators found that acute myeloid leukemia blast-released exosomes enhanced CD3 T cell apoptosis in both CD4 and CD8 T cells.

Glioblastoma Cellular MAP4K1 Facilitates Tumor Growth and Disrupts T Effector Cell Infiltration

[Life Science Alliance] The authors found that MAP4K1 was highly expressed in the glioma cells of human glioblastoma multiforme (GBM) specimens.They found that GBM cell-derived MAP4K1 impaired T cell migration and reduced CD8+ T cell infiltration.

Vitamin D3 Regulates PM-Driven Primary Human Neutrophil Inflammatory Responses

[Scientific Reports] Researchers investigated the impact of standard urban particulate matter (PM) and PM2.5 collected from Chiang Mai, Thailand, on human peripheral blood neutrophil functions.

Secretomes of M1 and M2 Macrophages Decrease the Release of Neutrophil Extracellular Traps

[Scientific Reports] To analyze whether cytokines or immune cells could inhibit neutrophil extracellular trap (NET) formation, human granulocytes were incubated with IL-4, IL-10, transforming growth factor beta-2 or adenosine and then stimulated to release NETs.

YTHDF1 Shapes “Cold” Tumor and Inhibits CD8+ T Cells Infiltration and Function in Breast Cancer

[Experimental Cell Research] The downregulation of YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) promoted the expression of pro-inflammatory markers and improved the anti-cancer ability of immune cells in breast cancer.

Identifying Physiological Tissue Niches That Support the HIV Reservoir in T Cells

[mBio] Investigators discuss the cellular and molecular cues that are important for memory T cell homeostasis and highlight opportunities for HIV to hijack normal immunological processes to establish long-term viral persistence.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.