Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Longitudinal Magnetic Resonance Imaging Tracking of Transplanted Neural Progenitor Cells in the Spinal Cord Utilizing the Bright-Ferritin Mechanism

[Stem Cells Translational Medicine] Investigators applied a novel bright-ferritin magnetic resonance imaging mechanism to track human neural progenitor cells (hNPC) transplants longitudinally and on demand in the rat spinal cord. They genetically modified hNPCs to stably overexpress human ferritin.

Efficient Site-Specific Integration of Large Genes in Mammalian Cells via Continuously Evolved Recombinases and Prime Editing

[Nature Biomedical Engineering] The authors showed that phage-assisted continuous evolution enhances prime-editing-assisted site-specific integrase gene editing, which coupled the programmability of prime editing with the ability of recombinases to precisely integrate large DNA cargoes exceeding 10 kilobases.

Metabolic Profiling of CD19+ Cells in Chronic Lymphocytic Leukemia by Single-Cell Mass Spectrometry Imaging

[Clinica Chimica Acta] Investigators developed a single-cell mass spectrometry imaging of human CD19+ lymphocytes and metabolic profiling of chronic lymphocytic leukemia.

The Causal Relationship Between Autoimmune Diseases and Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study

[PLOS One] Scientists investigated the potential causal relationship between autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and Type 1 diabetes, and age-related macular degeneration.

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Dose Escalation Study to Evaluate the Safety and Pharmacokinetics/Pharmacodynamics of PF-06835375, a C-X-C Chemokine Receptor Type...

[Arthritis Research & Therapy] Researchers evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF‑06835375, a potent selective afucosyl immunoglobulin G1 antibody targeting C-X-C chemokine receptor type 5 that potentially depleted B cells, follicular T helper (Tfh) cells, and circulating Tfh-like cells, in patients with systemic lupus erythematosus and rheumatoid arthritis.

Human γδ T Cells in Diverse Tissues Exhibit Site-Specific Maturation Dynamics Across the Life Span

[Science Immunology] Investigators analyzed the phenotype, transcriptome, function, and repertoire of human γδ T cells in blood and mucosal and lymphoid tissues from 176 donors across the life span, revealing distinct profiles in children compared with adults.

High-Throughput Transcriptome Profiling Indicates Ribosomal RNAs to Be Associated with Resistance to Immunotherapy in Non-small Cell Lung Cancer (NSCLC)

[Journal of Immunotherapy of Cancer] Scientists used retrospective cohorts of immune checkpoint inhibitor treated patients with non-small cell lung cancer (NSCLC), to discover and validate spatially resolved protein markers associated with resistance to programmed cell death protein-1 axis inhibition.

Changes in T Cell Subsets Occur in Interstitial Lung Disease and May Contribute to Pathology via Complicated Immune Cascade

[APMIS] The authors investigated the expression profiles of transcription factors, cytokines, and co-stimulatory molecules in helper T-cell subsets within bronchoalveolar lavage samples of patients with interstitial lung diseases.

Comparison of the Effects of Remimazolam Tosylate and Propofol on Immune Function and Hemodynamics in Patients Undergoing Laparoscopic Partial Hepatectomy: A Randomized Controlled Trial

[BMC Anesthesiology] Researchers investigated the differences in immune function and intraoperative hemodynamics between patients who underwent laparoscopic partial hepatectomy with remimazolam tosylate and those who underwent laparoscopic partial hepatectomy with propofol.

SiSaf’s Bio-Courier Technology Enables Clinical Trial Success for Topical Treatment of Mild to Moderate Alopecia Areata

[SiSag, Ltd.] SiSaf, Ltd. announced that a licensee of the ProSilic® variant of its technology has reported positive topline results from a randomized, placebo-controlled, multi-dose Phase II trial evaluating its topical treatment for mild to moderate alopecia areata, commonly known as spot baldness.

Cellular and Humoral Immunogenicity against SARS-CoV-2 Vaccination or Infection Is Associated with the Memory Phenotype of T- and B-lymphocytes in Adult Allogeneic Hematopoietic Cell...

[International Journal of Hematology] Scientists conducted a cross-sectional study to evaluate cellular and humoral immunogenicity against SARS-CoV-2 vaccination or infection and examined how lymphocyte subpopulations in peripheral blood correlate with cellular and humoral immunogenicity in adult allogeneic hematopoietic cell transplantation recipients.

Immune Profiling of Age and Adjuvant-Specific Activation of Human Blood Mononuclear Cells In Vitro

[Communications Biology] Scientists demonstrated the application of mass cytometry and cutting-edge computational approaches to characterize immune responses across immunologically distinct age groups and may inform identification of the bespoke adjuvantation systems tailored to enhance immunity in distinct vulnerable populations.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.