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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Boehringer Ingelheim and Cue Biopharma Partner to Develop Next-Generation Treatment for Autoimmune and Inflammatory Diseases
Boehringer Ingelheim and Cue Biopharma, Inc. announced a strategic research collaboration and license agreement to develop and commercialize Cue Biopharma’s CUE-501 product candidate, a...
Allogeneic NK Cells with a Bispecific Innate Cell Engager in Refractory Relapsed Lymphoma: A Phase 1 Trial
[Nature Medicine] Researchers studied cord-blood-derived cytokine-preactivated and expanded NK cells precomplexed with AFM13 in patients with CD30+ lymphoma refractory to brentuximab vedotin and checkpoint inhibitors.
Cardiac PDK4 Promotes Neutrophilic PFKL Methylation and Drives the Innate Immune Response in Diabetic Myocardial Infarction
[Pharmacological Research] Investigators revealed the crucial role of cardiomyocyte metabolism in NETosis, shedding light on the role of LA as a vital signaling molecule in the crosstalk between cardiomyocytes and neutrophils.
Proteome Alterations in Peripheral Immune Cells of DLBCL Patients and Evidence of Cancer Extracellular Vesicles Involvement
[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Given the primary localization of diffuse large B-cell lymphoma (DLBCL) and the effect of tumors on the systemic immune response, we investigated the proteome of DLBCL patients' and healthy donors peripheral immune cells.
Memory-Promoting Function of miR-379-5p Attenuates CD8+ T Cell Exhaustion by Targeting Immune Checkpoints
[Journal For Immunotherapy of Cancer] Investigators focused on miR-379-5p, which counteracted T cell exhaustion and enhanced antitumor responses.
Targeting Site-Specific N-Glycosylated B7H3 Induces Potent Antitumor Immunity
[Nature Communications] Scientists identified that N-glycans attached to asparagine residues N91/309 and N104/322 are required for proper B7H3 localization on the cell surface membrane.
T Cells Promote Distinct Transcriptional Programs of Cutaneous Inflammatory Disease in Keratinocytes and Dermal Fibroblasts
[Journal of Investigative Dermatology] Investigators showed that functionally diverse circulating and skin-resident CD4+CLA+ T cell populations promote distinct transcriptional outcomes in human keratinocytes and fibroblasts associated with inflamed or healthy tissue.
Multimodal Glioma Immunotherapy Combining TLR9-Targeted STAT3 Antisense Oligodeoxynucleotides with PD1 Immune Checkpoint Blockade
[Neuro-Oncology] Scientists suggested rationale for the glioblastoma immunotherapy using CpG-STAT3dsASO to disrupt GAMs-dependent immune evasion, thereby restoring sensitivity to PD1-blockade and facilitating T cell-mediated antitumor immune responses.
Emerging Strategies of Cell and Gene Therapy Targeting Tumor Immune Microenvironment
[Journal of Experimental & Clinical Cancer Research] The authors conduct a foundational overview of the classification of cell and gene therapy in treating solid tumors and explore how it targets the crosstalk between cancer cells and the tumor immune microenvironment from cellular and molecular perspectives.
Integrating Multi-Omics Data Reveals the Antitumor Role and Clinical Benefits of Gamma-Delta T Cells in Triple-Negative Breast Cancer
[BMC Cancer] Scientists provided novel insight and a theoretical basis for individualized therapy of patients with TNBC based on γδT cells.
A Phase III Trial of Inebilizumab in Generalized Myasthenia Gravis
[New England Journal of Medicine] In this Phase III, double-blind, randomized, placebo-controlled trial, scientists enrolled participants with myasthenia gravis who had anti–acetylcholine receptor antibodies or anti–muscle-specific kinase antibodies.
Is Granulomatous Mastitis a Rheumatologic Disease? the Emerging Role of Rheumatologists in Disease Management
[Rheumatology International] Researchers explored the inflammatory mechanisms underlying granulomatous mastitis, emphasizing the roles of cytokines such as TNF-α, IL-6, and the Th17 axis in sustaining granulomatous inflammation.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
