DNMT3A Haploinsufficiency Causes Dichotomous DNA Methylation Defects at Enhancers in Mature Human Immune Cells

The authors demonstrated that DNMT3A haploinsufficiency impaired the gain of DNA methylation at decommissioned enhancers, while simultaneously and unexpectedly impairing DNA demethylation of newly activated enhancers in mature human myeloid cells.
[Journal of Experimental Medicine]
Lim, J.-Y., Duttke, S. H., Baker, T. S., Lee, J., Gambino, K. J., Venturini, N. J., Ho, J. S. Y., Zheng, S., Fstkchyan, Y. S., Pillai, V., Fajgenbaum, D. C., Marazzi, I., Benner, C., & Byun, M. (2021). DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells. Journal of Experimental Medicine, 218(e20202733). https://doi.org/10.1084/jem.20202733 Cite
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The Human Memory T Cell Compartment Changes across Tissues of the Female Reproductive Tract

Scientists examined CD4 T cells in donor-matched vaginal, ecto- and endocervical tissues, which differ in mucosal structure and exposure to external environmental stimuli.
[Mucosal Immunology]
Woodward Davis, A. S., Vick, S. C., Pattacini, L., Voillet, V., Hughes, S. M., Lentz, G. M., Kirby, A. C., Fialkow, M. F., Gottardo, R., Hladik, F., Lund, J. M., & Prlic, M. (2021). The human memory T cell compartment changes across tissues of the female reproductive tract. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-021-00406-6 Cite
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NANOBIOTIX Partners With LianBio to Develop and Commercialize Potential First-in-Class Radioenhancer NBTXR3 Across Tumor Types and Therapeutic Combinations in China and Other Asian Markets

NANOBIOTIX announced a partnership with LianBio to develop and commercialize Nanobiotix lead product candidate NBTXR3, a potential first-in-class radioenhancer, in Greater China, South Korea, Singapore and Thailand.
[NANOBIOTIX (BusinessWire, Inc.)]
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New Grant-Funded Research Could Help Improve Therapies for Sepsis

A University of Kentucky College of Medicine professor has been awarded a $1.9 million National Institutes of Health grant for his research on the body’s immune response to sepsis, which could potentially help to improve therapies for the common disease.
[University ff Kentucky (EurekAlert!)]
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CRISPR Therapeutics, Nkarta to Jointly Develop Engineered Natural Killer Cells as Cancer Treatments

Off-the-shelf treatments for cancer made from genetically engineered T cells and natural killer, or NK, cells have each shown promise in clinical trials. Two biotech companies- Nkarta and CRISPR Therapeutics- announced a partnership that aims to merge the two immune-cell approaches together.
[STAT News]
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Bidirectional Crosstalk between Eosinophils and Esophageal Epithelial Cells Regulates Inflammatory and Remodeling Processes

Researchers investigated the crosstalk between human eosinophils and esophageal epithelial cells. They reported that blood-derived eosinophils had prolonged survival when co-cultured with epithelial cells.
[Mucosal Immunology]
Dunn, J. L. M., Caldwell, J. M., Ballaban, A., Ben-Baruch Morgenstern, N., Rochman, M., & Rothenberg, M. E. (2021). Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-021-00400-y Cite
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Germline Features Associated with Immune Infiltration in Solid Tumors

The authors analyzed seven million autosomal germline variants in the TCGA cohort and test for association with established immune-related phenotypes that describe the tumor immune microenvironment.
[Cell Reports]
Shahamatdar, S., He, M. X., Reyna, M. A., Gusev, A., AlDubayan, S. H., Allen, E. M. V., & Ramachandran, S. (2020). Germline Features Associated with Immune Infiltration in Solid Tumors. Cell Reports, 30(9), 2900-2908.e4. https://doi.org/10.1016/j.celrep.2020.02.039 Cite
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CD1a Selectively Captures Endogenous Cellular Lipids That Broadly Block T Cell Response

Crystal structures show that the short cellular SMs stabilized a triad of surface residues to remain flush with CD1a, but the longer lipids forced the phosphocholine group to ride above the display platform to hinder TCR approach.
[Journal of Experimental Medicine]
Cotton, R. N., Wegrecki, M., Cheng, T.-Y., Chen, Y.-L., Veerapen, N., Le Nours, J., Orgill, D. P., Pomahac, B., Talbot, S. G., Willis, R., Altman, J. D., de Jong, A., Van Rhijn, I., Clark, R. A., Besra, G. S., Ogg, G., Rossjohn, J., & Moody, D. B. (2021). CD1a selectively captures endogenous cellular lipids that broadly block T cell response. Journal of Experimental Medicine, 218(e20202699). https://doi.org/10.1084/jem.20202699 Cite
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Emerging Concepts in Intestinal Immune Control of Obesity-Related Metabolic Disease

Scientists highlight evolving concepts centered on intestinal immunity, diet, and the microbiota to provide a working model of obesity-related metabolic disease.
[Nature Communications]
Khan, S., Luck, H., Winer, S., & Winer, D. A. (2021). Emerging concepts in intestinal immune control of obesity-related metabolic disease. Nature Communications, 12(1), 2598. https://doi.org/10.1038/s41467-021-22727-7 Cite
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Composite CD79A/CD40 Costimulatory Endodomain Enhances CD19CAR-T Cell Proliferation and Survival

Researchers developed a composite costimulatory domain of a B cell signaling moiety, CD79A/CD40, to induce a nuclear translocating signal, NF-κB, to synergize with other T cell signals and improve CAR-T cell function.
[Molecular Therapy]
Julamanee, J., Terakura, S., Umemura, K., Adachi, Y., Miyao, K., Okuno, S., Takagi, E., Sakai, T., Koyama, D., Goto, T., Hanajiri, R., Hudecek, M., Steinberger, P., Leitner, J., Nishida, T., Murata, M., & Kiyoi, H. (2021). Composite CD79A/CD40 costimulatory endodomain enhances CD19CAR-T cell proliferation and survival. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.04.038 Cite
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Tumor-Associated Neutrophils Drive B-Cell Recruitment and Their Differentiation to Plasma Cells

Researchers showed that tumor-associated neutrophils (TANs) actively participated in the recruitment of B cells to the tumor microenvironment and identified TNFα as the major cytokine mediating B cell chemotaxis by TANs.
[Cancer Immunology Research]
Shaul, M. E., Zlotnik, A., Tidhar, E., Schwartz, A., Arpinati, L., Kaisar-Iluz, N., Mahroum, S., Mishalian, I., & Fridlender, Z. G. (2021). Tumor-associated neutrophils drive B-cell recruitment and their differentiation to plasma cells. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0839 Cite
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