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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Novel Bispecific Antibody-Drug Conjugate Targeting PD-L1 and B7-H3 Enhances Antitumor Efficacy and Promotes Immune-Mediated Antitumor Responses
[Journal for ImmunoTherapy of Cancer] Investigators examined the therapeutic efficacy and potential mechanisms of a bispecific antibody-drug conjugate in laryngeal squamous cell carcinoma.
Deficiency of Metabolic Regulator PKM2 Activates the Pentose Phosphate Pathway and Generates TCF1+ Progenitor CD8+ T Cells to Improve Immunotherapy
[Nature Immunology] Investigators showed that targeting glycolysis through deletion of pyruvate kinase muscle 2 (PKM2) results in elevated pentose phosphate pathway activity.
Global Autoimmune Institute Invests over $800,000 in La Jolla Institute for Immunology, Strengthening Autoimmune Disease Research and Patient Resources
[La Jolla Institute for Immunology] La Jolla Institute for Immunology announced new milestones in its partnership with the Global Autoimmune Institute, marking a major step forward in the advancement of autoimmune disease research and patient-centered resources.
Innate Immune Cell Activation by Adjuvant AS01 in Human Lymph Node Explants Is Age-Independent
[Journal of Clinical Investigation] To bridge data obtained in animals to humans, scientists have developed an in situ human lymph node explant model to investigate how adjuvants initiate immunity.
IL-7–Dependent and –Independent Lineages of IL-7R–Dependent Human T Cells
[Journal of Clinical Investigation] Investigators reported six adults from four kindreds and three ancestries carrying homozygous IL7 loss-of-function variants resulting in combined immunodeficiency.
Loss of Synovial Tissue Macrophage Homeostasis Precedes Rheumatoid Arthritis Clinical Onset
[Science Advances] The authors performed an in-depth investigation into the myeloid cellular landscape in the synovium of patients with rheumatoid arthritis (RA), “individuals at risk” of RA, and healthy controls.
Neoantigen Immunogenicity Landscapes and Evolution of Tumor Ecosystems during Immunotherapy with Nivolumab
[Nature Medicine] 80 patients with non-small cell lung cancer were enrolled in the biomarker cohort of CheckMate 153, which collected radiographic guided biopsy samples before treatment and during treatment with nivolumab.
Novel FABP4+C1q+ Macrophages Enhance Antitumor Immunity and Associated with Response to Neoadjuvant Pembrolizumab and Chemotherapy in NSCLC via AMPK/JAK/STAT Axis
[Cell Death & Disease] Scientists performed single-cell RNA sequencing and identified a novel FABP4+C1q+ macrophage subtype, which exhibited stronger proinflammatory cytokine production and phagocytic ability.
Tumor-Infiltrating Mast Cells Confer Resistance to Immunotherapy in Pancreatic Cancer
[iScience] Pancreatic ductal adenocarcinoma (PDAC) exhibits an immunosuppressive tumor microenvironment (TME) contributing to its therapeutic resistance. Researchers reported that mast cells infiltrating the PDAC TME fostered this immunosuppression and desmoplasia.
BTN2A1 Targeting Reprograms M2-Like Macrophages and TAMs via SYK and MAPK Signaling
[Cell Reports] Investigators developed anti-BTN2A1 monoclonal antibodies, and notably, one clone demonstrated a robust inhibitory effect on M2-like macrophage differentiation, inducing a shift toward an M1-like phenotype both in vitro and ex vivo in tumor-associated macrophages from patients with cancer.
Multidimensional Profiling of Human T Cells Reveals High CD38 Expression, Marking Recent Thymic Emigrants and Age-Related Naive T Cell Remodeling
[Immunity] Analysis of single-cell RNA-seq/ATAC-seq data distinguished recent thymic emigrants (RTEs) by the expression of SOX4, IKZF2, and TOX and CD38 protein, whereby surface CD38hi expression universally identified CD8+ and CD4+ RTEs.
Immunotherapy Response and Resistance in Patients with Advanced Uveal Melanoma: A Retrospective Cohort Study
[Clinical and Experimental Medicine] Investigators described the radiological response patterns of metastatic uveal melanoma patients treated with immunotherapy.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
