Researchers examined the effect of B cell stimuli on lymphoid stromal cells in follicular lymphoma (FL). FL B cells interacted primarily with CD49a+ fibroblastic reticular cells.
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Mourcin, F., Verdière, L., Roulois, D., Amin, R., Lamaison, C., Sibut, V., Thamphya, B., Pangault, C., Monvoisin, C., Huet, S., Seffals, M., Baulande, S., Mechta-Grigoriou, F., Legoix, P., Rossille, D., Guirriec, M., Léonard, S., Cartron, G., Salles, G., … Tarte, K. (2021). Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.05.019 Cite
Researchers used multicolor flow cytometry and immunohistochemistry to elucidate abundance and spatial distribution of these antigen-presenting B cells in blood and tumor samples of 238 cancer patients.
[Cancer Immunology Research]
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CD86+ antigen-presenting B cells are increased in cancer, localize in tertiary lymphoid structures, and induce specific T-cell responses | Cancer Immunology Research. (n.d.). Retrieved June 22, 2021, from https://cancerimmunolres.aacrjournals.org/content/early/2021/06/21/2326-6066.CIR-20-0949 Cite
Scientists investigated this topic in an in vitro model using primary human T cells and in an immuno-nutritional intervention study enrolling healthy volunteers.
[EMBO Molecular Medicine]
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Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming | EMBO Molecular Medicine. (n.d.). Retrieved June 22, 2021, from https://www.embopress.org/doi/full/10.15252/emmm.202114323 Cite
The authors analyzed the profiling of immune cells in the peripheral blood of steroid-sensitive nephrotic syndrome patients and steroid-resistant nephrotic syndrome patients before and after standard steroid treatment to clarify the immunological mechanism of nephrotic syndrome patients.
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Scientists made a comprehensive review on the outcomes resulted from the combination of CAR T-cell immunotherapy and oncolytic virotherapy for the treatment of solid cancers.
[Cancer Gene Therapy]
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Rezaei, R., Esmaeili Gouvarchin Ghaleh, H., Farzanehpour, M., Dorostkar, R., Ranjbar, R., Bolandian, M., Mirzaei Nodooshan, M., & Ghorbani Alvanegh, A. (2021). Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-021-00359-9 Cite
Investigators described elevated infiltration by regulatory T cells as the most common feature, while other lymphocyte subsets and also expression of immune-regulatory molecules on tumor-infiltrating lymphocytes showed site-specific variation.
[npj Precision Oncology]
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Thelen, M., Wennhold, K., Lehmann, J., Garcia-Marquez, M., Klein, S., Kochen, E., Lohneis, P., Lechner, A., Wagener-Ryczek, S., Plum, P. S., Velazquez Camacho, O., Pfister, D., Dörr, F., Heldwein, M., Hekmat, K., Beutner, D., Klussmann, J. P., Thangarajah, F., Ratiu, D., … Schlößer, H. A. (2021). Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy. Npj Precision Oncology, 5(1), 1–12. https://doi.org/10.1038/s41698-021-00196-x Cite
Researchers found that the polyclonal Treg cell repertoire is pre-enriched to recognize antigens presented by tumor-associated conventional dendritic cells.
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Marangoni, F., Zhakyp, A., Corsini, M., Geels, S. N., Carrizosa, E., Thelen, M., Mani, V., Prüßmann, J. N., Warner, R. D., Ozga, A. J., Pilato, M. D., Othy, S., & Mempel, T. R. (2021). Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.05.027 Cite
Scientists investigated the effects of ionizing radiation on cancer-associated fibroblast (CAF)-mediated regulation of dendritic cells (DCs). CAFs were obtained from freshly operated lung cancer tissues, while DCs were procured from peripheral blood of healthy donors.
[Frontiers in Immunology]
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Frontiers | Ionizing Radiation Curtails Immunosuppressive Effects From Cancer-Associated Fibroblasts on Dendritic Cells | Immunology. (n.d.). Retrieved June 21, 2021, from https://www.frontiersin.org/articles/10.3389/fimmu.2021.662594/full Cite
Scientists review the cells that produce IFNγ and the different effects of IFNγ in the tumor microenvironment, highlighting the pleiotropic nature of this multifunctional and abundant cytokine.
[Nature Reviews Immunology]
A better understanding of these CD8+ T cell states may reveal novel strategies to augment clearance of chronic viral infection and cancer and to mitigate self-reactivity leading to tissue damage in autoimmunity.
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Scientists showed that a lack of bifidobacteria, and in particular depletion of genes required for human milk oligosaccharide utilization from the metagenome, is associated with systemic inflammation and immune dysregulation early in life.
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Henrick, B. M., Rodriguez, L., Lakshmikanth, T., Pou, C., Henckel, E., Arzoomand, A., Olin, A., Wang, J., Mikes, J., Tan, Z., Chen, Y., Ehrlich, A. M., Bernhardsson, A. K., Mugabo, C. H., Ambrosiani, Y., Gustafsson, A., Chew, S., Brown, H. K., Prambs, J., … Brodin, P. (2021). Bifidobacteria-mediated immune system imprinting early in life. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.05.030 Cite