Category Archives: Human Immunology

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
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Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.

Innate Immunity at the Crossroads of Healthy Brain Maturation and Neurodevelopmental Disorders

The authors discuss the essential roles of microglia and innate immune signaling in the assembly and maintenance of a properly functioning nervous system.
[Nature Reviews Immunology]
Zengeler, K. E., & Lukens, J. R. (2021). Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-020-00487-7 Cite
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Impedimetric Microfluidic Sensor‐in‐a‐Tube for Label‐Free Immune Cell Analysis

An innovative rolled‐up impedimetric microfulidic sensor, called sensor‐in‐a‐tube, was introduced for the simultaneous analysis of single human monocytes CD14+ and their extracellular medium upon liposaccharides‐mediated activation.
[Small]
Egunov, A. I., Dou, Z., Karnaushenko, D. D., Hebenstreit, F., Kretschmann, N., Akgün, K., Ziemssen, T., Karnaushenko, D., Medina‐Sánchez, M., & Schmidt, O. G. (n.d.). Impedimetric Microfluidic Sensor-in-a-Tube for Label-Free Immune Cell Analysis. Small, n/a(n/a), 2002549. https://doi.org/https://doi.org/10.1002/smll.202002549 Cite
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A Bispecific Single Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses towards CD1d in Chronic Lymphocytic Leukemia

Scientists evaluated CD1d expression in a cohort of 78 untreated CLL patients and generated a CD1d-specific Vγ9Vδ2-T cell engager based on single-domain antibodies.
[Clinical Cancer Research]
Weerdt, I. de, Lameris, R., Ruben, J. M., Boer, R. de, Kloosterman, J., King, L. A., Levin, M.-D., Parren, P. W. H. I., Gruijl, T. D. de, Kater, A. P., & Vliet, H. J. van der. (2021). A bispecific single domain antibody boosts autologous Vγ9Vδ2-T cell responses towards CD1d in chronic lymphocytic leukemia. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-4576 Cite
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Personalized Neoantigen Pulsed Dendritic Cell Vaccine for Advanced Lung Cancer

Scientists attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous dendritic cell vaccine and conducted a single-arm, 2 medical centers, pilot study initiated by the investigator.
[Signal Transduction and Targeted Therapy]
Ding, Z., Li, Q., Zhang, R., Xie, L., Shu, Y., Gao, S., Wang, P., Su, X., Qin, Y., Wang, Y., Fang, J., Zhu, Z., Xia, X., Wei, G., Wang, H., Qian, H., Guo, X., Gao, Z., Wang, Y., … Yang, L. (2021). Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer. Signal Transduction and Targeted Therapy, 6(1), 1–12. https://doi.org/10.1038/s41392-020-00448-5 Cite
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Perfect Adaptation of CD8+ T Cell Responses to Constant Antigen Input Over a Wide Range of Affinities Is Overcome by Costimulation

Researchers observed that in vitro–expanded primary human T cells exhibited perfect adaptation with respect to cytokine production to constant antigen stimulation across a 100,000-fold variation in affinity with partial T cell receptors down-regulation.
[Science Signaling]
Trendel, N., Kruger, P., Gaglione, S., Nguyen, J., Pettmann, J., Sontag, E. D., & Dushek, O. (2021). Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation. Science Signaling, 14(666). https://doi.org/10.1126/scisignal.aay9363 Cite
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Characterization of Ascites- and Tumor-Infiltrating γδ T Cells Reveals Distinct Repertoires and a Beneficial Role in Ovarian Cancer

The authors demonstrated that tumor-infiltrating γδ T cells isolated from patients with ovarian cancer have distinct T cell receptors and exhibit more innate-like functions compared to blood- or ascites-derived γδ T cells.
[Science Translational Medicine]
Foord, E., Arruda, L. C. M., Gaballa, A., Klynning, C., & Uhlin, M. (2021). Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer. Science Translational Medicine, 13(577). https://doi.org/10.1126/scitranslmed.abb0192 Cite
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Personal Neoantigen Vaccines Induce Persistent Memory T Cell Responses and Epitope Spreading in Patients with Melanoma

Scientists evaluated the clinical outcome and circulating immune responses of eight patients with surgically resected stage IIIB/C or IVM1a/b melanoma,
[Nature Medicine]
Hu, Z., Leet, D. E., Allesøe, R. L., Oliveira, G., Li, S., Luoma, A. M., Liu, J., Forman, J., Huang, T., Iorgulescu, J. B., Holden, R., Sarkizova, S., Gohil, S. H., Redd, R. A., Sun, J., Elagina, L., Giobbie-Hurder, A., Zhang, W., Peter, L., … Ott, P. A. (2021). Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma. Nature Medicine, 1–11. https://doi.org/10.1038/s41591-020-01206-4 Cite
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Nanoparticle T-Cell Engagers as a Modular Platform for Cancer Immunotherapy

Scientists developed nanoparticle-based bispecific T-cell engagers, which were liposomes decorated with anti-CD3 monoclonal antibodies (mAbs) targeting T cells, and mAbs targeting the cancer antigen.
[Leukemia]
Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy | Leukemia. (n.d.). Retrieved January 22, 2021, from https://www.nature.com/articles/s41375-021-01127-2 Cite
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HLA Class I Loss in Colorectal Cancer: Implications for Immune Escape and Immunotherapy

Investigators summarize the prevalence and molecular mechanisms behind HLA-I loss in colorectal cancer (CRC), and discuss HLA-I expression/loss in the context of the newly identified CRC molecular subtypes.
[Cellular & Molecular Immunology]
Anderson, P., Aptsiauri, N., Ruiz-Cabello, F., & Garrido, F. (2021). HLA class I loss in colorectal cancer: implications for immune escape and immunotherapy. Cellular & Molecular Immunology, 1–10. https://doi.org/10.1038/s41423-021-00634-7 Cite
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Tumor-Associated Myeloid Cells: Diversity and Therapeutic Targeting

Scientists provide an overview of the recent literature on the ever-growing complexity of the biology of tumor-associated macrophages and tumor-associated neutrophils and the development of the most promising approaches to target these populations therapeutically in cancer patients.
[Cellular & Molecular Immunology]
Mantovani, A., Marchesi, F., Jaillon, S., Garlanda, C., & Allavena, P. (2021). Tumor-associated myeloid cells: diversity and therapeutic targeting. Cellular & Molecular Immunology, 1–13. https://doi.org/10.1038/s41423-020-00613-4 Cite
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Innate Immunity at the Crossroads of Healthy Brain Maturation and Neurodevelopmental Disorders

The authors discuss the essential roles of microglia and innate immune signaling in the assembly and maintenance of a properly functioning nervous system.
[Nature Reviews Immunology]
Zengeler, K. E., & Lukens, J. R. (2021). Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-020-00487-7 Cite
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