Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Cancer Suppresses Mitochondrial Chaperone Activity in Macrophages to Drive Immune Evasion

November 6, 2025

[Nature Immunology] Researchers identified TNF receptor-associated protein-1 (TRAP1), a mitochondrial HSP90 chaperone, as a metabolic checkpoint that restrains oxidative respiration and limits macrophage suppressive function.

Neutrophils and Neutrophil Extracellular Traps: Double-Edged Swords in Cancer Pathophysiology and Therapy Resistance

November 6, 2025

[Cell Communication and Signaling] Neutrophils have garnered focus in cancer research due to their participation in cancer initiation, proliferation and metastasis. As important players in the tumor microenvironment, tumor-associated neutrophils are viewed as “a double-edged sword” in cancer pathophysiology.

Interferon Regulatory Factor 1 Enhances T Cell Differentiation in Patients with Myasthenia Gravis

November 6, 2025

[Neural Regeneration Research] The authors explored the function of interferon regulatory factor 1 in myasthenia gravis, with an aim to understand the underlying mechanisms.

Peanut Allergy Oral Immunotherapy Drives Single-Cell Multi-Omic Changes in Peanut-Reactive T Cells Associated with Sustained Unresponsiveness

November 6, 2025

[Nature Immunology] Researchers analyzed single-cell RNA and protein immunophenotypes and T cell receptor repertoires of peanut reactive CD4+ T cells from a Phase II peanut oral immunotherapy trial cohort.

New Power in Cancer Immunotherapy: The Rise of Chimeric Antigen Receptor Macrophage (CAR-M)

October 29, 2025

[Journal of Translational Medicine] Scientists highlight the construction strategies and preclinical and clinical studies of CAR-engineered macrophages, introduce the anti-tumor mechanisms, and discuss their advantages and disadvantages compared with other CAR-engineered effector cells.

Genome-Edited Allogeneic CAR-T Cells: The Next Generation of Cancer Immunotherapies

October 28, 2025

[Journal of Hematology & Oncology] The authors summarize the progress of universal allogeneic CAR-T cell therapies, addresses the critical challenges, and discusses the future directions for their clinical implementation.

Single-Cell Analysis of Human Thymus and Peripheral Blood Unveils the Dynamics of T Cell Development and Aging

October 28, 2025

[Nature Aging] Using single-cell sequencing, scientists analyzed 387,762 cells from human thymus and peripheral blood of young and aged individuals. Aged thymus were enriched in mature T cells with low SOX4 expression and inflammatory profiles but depleted of thymic epithelial cells and expression of tissue-restricted antigens.

Structural Immunity: Immune Cells As Architects of Tissue Barriers

October 28, 2025

[Nature Reviews Immunology] Scientists place independent findings from several groups into a working model of immune cells as the architects of tissue barriers, to present a framework on which new concepts and findings in this area can develop.

Hypoxia Induces Histone Clipping and H3K4me3 Loss in Neutrophil Progenitors Resulting in Long-Term Impairment of Neutrophil Immunity

October 28, 2025

[Nature Immunology] Scientists show that patients three to six months after recovering from acute respiratory distress syndrome have persistently impaired circulating neutrophil effector functions and an increased susceptibility to secondary infections. These defects are linked to a widespread loss of the activating histone mark H3K4me3 in genes that are crucial for neutrophil activities.

Immunotherapy for Asthma

October 28, 2025

[Cellular & Molecular Immunology] The authors explore the underlying immunological mechanisms of various asthma endotypes. They also provide an overview of the different types of immunotherapies currently available to asthmatic patients and their clinical efficacy.

Epigenetic Regulation of T Cell Exhaustion in Cancer

October 28, 2025

[Nature Reviews Cancer] Investigators discuss how T cell subset-specific gene regulatory programs limit immunotherapy success and theorize on the development of next-generation strategies for increasing the clinical breadth, efficacy, and durability of T cell immunotherapy.

Swarm Oncology Announces Research Collaboration with a Leading Hospital to Advance T Cell Therapies for Advanced Solid Cancers

October 28, 2025

[Swarm Oncology, Ltd. (Biospace)] Swarm Oncology, Ltd. announced a research collaboration with a leading US clinic to further broaden the feasibility and manufacturing of research-scale Swarm-T cell preparations by using samples from patients treated in the clinic’s cancer vaccine studies.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.