Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma

Researchers demonstrated the feasibility of incorporating multisector sampling in cancer vaccine design and provided information on the clinical applicability of clonality, distribution, and immunogenicity...

Anti-Tumor Activity of a Novel LAIR1 Antagonist in Combination with Anti-PD-1 to Treat Collagen-Rich Solid Tumors

[Molecular Cancer Therapeutics] Investigators reported leukocyte-associated immunoglobulin-like receptor 1 was associated with tumor stroma and was highly expressed by intratumoral myeloid cells in both human tumors and mouse models of cancer.

Lactobacillus reuteri Vesicles Regulate Mitochondrial Function of Macrophages to Promote Mucosal and Cutaneous Wound Healing

[Advanced Science] Researchers revealed, for the initial time, the significant enhancement of mucosal and cutaneous wound healing by membrane vesicles secreted by the human commensal Lactobacillus reuteri through modulation of the inflammatory environment in wound tissue.

The CD318/CD6 Axis Limits Type 1 Diabetes Islet Autoantigen-Specific Human T Cell Activation

[Journal Of Autoimmunity] Scientists reported CD318 expression in a subpopulation of CD318+ myeloid dendritic, whereas the other peripheral blood populations were CD318 negative.

HERV-W Upregulation Expression in Bipolar Disorder and Schizophrenia: Unraveling Potential Links to Systemic Immune/Inflammation Status

[Retrovirology] Investigators assessed the level of human endogenous retrovirus W (HERV-W)-env expression and the systemic inflammatory profile through the concentration of IL-2, IL-4, IL-6, IL-10, TNF-α and INF-γ cytokines in bipolar disorder and schizophrenia patients.

HLA Reduction of Human T Cells Facilitates Generation of Immunologically Multi-compatible Cellular Products

[Blood Advances] Researchers showed that human leukocyte antigen knockout (HLA KO) does not alter T-cell functionality in vitro and in vivo. While HLA KO abrogated allogeneic T-cell responses, it elicited NK-cell recognition. To circumvent this problem, they demonstrated that selective editing of individual HLA class I molecules in primary human T cells was possible.

Bone Marrow CD8+ Trm Cells Induced by IL-15 and CD16+ Monocytes Contribute to HSPC Destruction in Human Severe Aplastic Anemia

[Clinical Immunology] Scientists performed single-cell RNA sequencing of peripheral blood and bone marrows and bone marrow mononuclear cells from severe aplastic anemia patients and healthy donors and identified a CD8+ T cell subset with a tissue residency phenotype (Trm) in bone marrow that exhibited high IFN-γ and FasL expression and have a higher ability to induce apoptosis in hematopoietic stem and progenitor cells in vitro through FasL expression.

Systemic Lupus Erythematosus

[Lancet] The authors discuss a diagnostic approach to symptoms in light of the latest classification criteria, which include a systematic evaluation of clinical manifestations and autoantibody profiles.

Sandoz Confirms European Commission Approval of Pyzchiva® (Ustekinumab), Further Strengthening Immunology Offering

[Sandoz] Sandoz announces that the European Commission has granted marketing authorization for Pyzchiva® (biosimilar ustekinumab), developed and registered by Samsung Bioepis.

B Cells and the Coordination of Immune Checkpoint Inhibitor Response in Patients With Solid Tumors

[Journal For Immunotherapy Of Cancer] Mechanisms of B cell response include antibody-dependent cellular cytotoxicity and phagocytosis, promotion of CD4+ and CD8+ T cell activation, maintenance of antitumor immune memory.

PD-L1- and IL-4-Expressing Basophils Promote Pathogenic Accumulation of T Follicular Helper Cells in Lupus

[Nature Communications] Scientists provided evidence for a direct functional relationship between T follicular helper (TFH) cells and basophils during lupus pathogenesis, both in humans and mice. PD-L1 upregulation on basophils and IL-4 production are associated with TFH and TFH2 cell expansions and with disease activity.

Inflammation and Cytomegalovirus Viremia during Pregnancy Drive Sex-Differentiated Differences in Mortality and Immune Development in HIV-Exposed Infants

[Nature Communications] In a secondary analysis of the SHINE trial in rural Zimbabwe researchers explored biological pathways underlying infant mortality, and maternal factors shaping immune development in HIV-exposed uninfected infants.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.