Human Inhibitory Leukocyte Ig-Like Receptors: From Immunotolerance to Immunotherapy

The authors discuss the immunoregulatory functions of human LILRBs and the potential of targeting them to manipulate immune responses in various pathologies.
[JCI Insight]
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INmune Bio, Inc. Announces Research Collaboration with Chinese University of Hong Kong to Evaluate INKmune in Nasopharyngeal Cancer

INmune Bio, Inc. announced that the company has entered into a pre-clinical research collaboration with Chinese University of Hong Kong to evaluate INKmune™ in nasopharyngeal cancer, a type of head and neck cancer.
[INmune Bio, Inc.]
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Identification of Shared Tumor Epitopes from Endogenous Retroviruses Inducing High-Avidity Cytotoxic T Cells for Cancer Immunotherapy

Six candidates among the most commonly shared HLA-A2 epitopes with evidence of translation were selected for immunological evaluation. In vitro priming assays confirmed the immunogenicity of these epitopes, which induced high-avidity CD8+ T cell clones.
[Science Advances]
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Multi-Objective Optimization Reveals Time- and Dose-Dependent Inflammatory Cytokine-Mediated Regulation of Human Stem Cell Derived T-cell Development

Using a defined engineered thymic niche system, investigators undertook a multi-stage statistical learning-based optimization campaign and identified IL-3 and tumor necrosis factor α as a stage- and dose-specific enhancers of cell proliferation and T-lineage differentiation.
[NPJ Regenerative Medicine]
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Exploiting Natural Killer Cell Engagers to Control Pediatric B Cell Precursor Acute Lymphoblastic Leukemia

Investigators tested the in vitro effect of different NK cell engagers, which triggered either NKp46 or NKp30 together with CD16A, and target either CD19 or CD20 to induce killing of pediatric B cell precursor acute lymphoblastic leukemia.
[Cancer Immunology Research]
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Polymorphonuclear Myeloid-Derived Suppressor Cells Are Abundant in Peripheral Blood of Cancer Patients and Suppress Natural Killer Cell Anti-Tumor Activity

Scientists showed that polymorphonuclear-myeloid-derived suppressor cells were present in high numbers in the polymorphonuclear of patients with primary or metastatic lung tumor.
[Frontiers in Immunology]
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Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome

Human and mouse model bronchoalveolar lavage fluid samples were analyzed for the presence and activity of cathepsin S and its endogenous inhibitors.
[American Journal of Respiratory and Critical Care Medicine]
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Pan-Cancer Analysis of GALNTs Expression Identifies a Prognostic of GALNTs Feature in Low Grade Glioma

Investigators used Oncomine and The Cancer Genome Atlas databases to analyze the transcription and survival effect of N-acetylgalactosaminyltransferase genes (GALNTs) in pan-cancer.
[Journal of Leukocyte Biology]
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Constructing a Novel Signature Based on Immune-Related lncRNA to Improve Prognosis Prediction of Cervical Squamous Cell Carcinoma Patients

Researchers assessed the correlation between immune infiltration status, chemotherapeutics sensitivity, immune checkpoint proteins, and the signature.
[Reproductive Sciences]
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NLRP3 Inflammasome Activation in Human Peripheral Blood Mononuclear Cells Induced by Venoms Secreted PLAM2s

Peripheral blood mononuclear cells were isolated by density gradient and incubated with RPMI, LPS, BthTX-I or BthTX-II isolated from Bothrops jararacussu venom, to evaluate viability, and the results showed that there was no cell death.
[International Journal of Biological Macromolecules]
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Biomarkers Related to Immune Checkpoint Inhibitors Therapy

The development of biomarkers is important for monitoring the effect of treatment, assessing the patient’s response to immune checkpoint inhibitors, determining adverse reactions, and predicting the direction of disease development.
[Biomedicine & Pharmacotherapy]
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