Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Novel Tri-Specific T Cell Engager Targeting IL-13Rα2 and EGFRvIII Provides Long-Term Survival in Heterogeneous GBM Challenge and Promotes Antitumor Cytotoxicity with Patient Immune Cells
Researchers described novel trivalent antibodies, DNA-encoded tri-specific T cell engagers, targeting two glioblastoma multiforme antigens, epidermal growth factor receptor variant III (EGFRvIII) and IL-13Rα2,...
Efficacy and Safety of Switching to Daily Bictegravir Plus Lenacapavir From a Complex Human Immunodeficiency Virus Treatment Regimen: A Randomized, Open-Label, Multicenter Phase II...
ARTISTRY-1 is a Phase II/III, operationally seamless, randomized, open-label, multicenter, active-controlled study. Phase II of the study enrolled adults with plasma HIV-1 RNA 50...
Cutaneous T Cell Lymphoma Atlas Reveals Malignant TH2 Cells Supported by a B Cell-Rich Tumor Microenvironment
Investigators performed single-cell and spatial transcriptomics analysis of skin from patients with mycosis fungoides-type cutaneous T cell lymphoma and an integrated comparative analysis with...
Integrated Single-Cell Transcriptome and TCR Profiles of Hepatocellular Carcinoma Highlight the Convergence on Interferon Signaling During Immunotherapy
[Journal For Immunotherapy of Cancer] Scientists comprehensively analyzed paired single-cell RNA transcriptome and T cell repertoire profiles from 14 hepatocellular carcinoma ascites samples, collected from 7 patients before and after treatment with the combination of sintilimab and bevacizumab.
Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma
[American Journal of Respiratory and Critical Care Medicine] Researchers determined the frequency and within-patient variability of corticosteroid-responsive type 1 (T1)-high, T2-high, and T1/T2-high asthma endotypes and whether virally influenced T1-high disease influences corticosteroid response in asthma.
Long-Term Follow Up in Anti-Contactin-1 Autoimmune Nodopathy
[Annals of Neurology] Scientists analyzed long-term clinical and biomarker features of anti-contactin-1 autoimmune nodopathy. Patients with anti-CNTN1+ autoimmune nodopathy detected in our laboratory from which clinical information was available were included.
In Human CD4+ T-Cells, Omeprazole Suppresses Proliferation, Downregulates V-ATPase, and Promotes Differentiation Toward an Autoimmunity-Favoring Phenotype
[International Immunopharmacology] Triggered by findings indicating a correlation between proton pump inhibitors usage and susceptibility to infectious or autoimmune diseases, investigators studied the impact of a pharmacological concentration of omeprazole on human CD4+ T cells.
Rheumatoid Arthritis: A Review of the Key Clinical Features and Ongoing Challenges of the Disease
[Panminerva Medica] The authors provide a comprehensive overview of rheumatoid arthritis, covering new research on the ‘pre-clinical’ phase of the disease, as well as its epidemiology, pathogenesis, clinical manifestations, diagnosis, imaging, and management strategies.
Moffitt Patient Is First To Receive Second CAR T Therapy for Ovarian Cancer
[Moffitt Cancer Center] Marisol Gallagher, with Drs. Robert Wenham and Monica Avila, received a second round of CAR T-cell therapy 18 months after her first round. Her care team hopes the second infusion will cure her ovarian cancer once and for all.
Safety and Activity of CTX130, a CD70-Targeted Allogeneic CRISPR-Cas9-Engineered CAR T-Cell Therapy, in Patients with Relapsed or Refractory T-Cell Malignancies (COBALT-LYM): A Single-Arm, Open-Label,...
[Lancet Oncology] Researchers assessed the safety and activity of CTX130, a CD70-directed, allogeneic CAR immunotherapy manufactured from healthy donor T cells, in patients with relapsed or refractory T cell lymphoma.
Assessing Human B Cell Responses to Influenza Virus Vaccines and Adjuvants in a PBMC-Derived In Vitro Culture System
[Vaccine] Investigators assessed whether B cells present in peripheral blood mononuclear cells responded to vaccines and reflected the effects of different vaccine formulations and adjuvants.
Dominant Negative Variants in ITPR3 Impair T Cell Ca2+ Dynamics Causing Combined Immunodeficiency
[Journal of Experimental Medicine] The importance of calcium as a second messenger in T cell signaling was exemplified by genetic deficiencies of STIM1 and ORAI1, which abolished store-operated calcium entry resulting in combined immunodeficiency.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.