Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Conserved γδ T Cell Selection by BTNL Proteins Limits Progression of Human Inflammatory Bowel Disease

[Science] Using mucosal samples obtained at colonoscopy from more than 150 individuals, scientists characterized the healthy human gut γδ T cell population.

Immunosuppressive CD10+ALPL+ Neutrophils Promote Resistance to Anti-PD-1 Therapy in HCC by Mediating Irreversible Exhaustion of T Cells

[Journal Of Hepatology] Investigators analyzed the transcriptomic profiling at a single-cell resolution within tumor tissues from hepatocellular carcinoma patients scheduled to receive anti-PD-1-based immunotherapy.

Acetate Acts as a Metabolic Immunomodulator by Bolstering T Cell Effector Function and Potentiating Antitumor Immunity in Breast Cancer

[Nature Cancer] The authors showed that acetate supplementation metabolically bolstered T cell effector functions and proliferation.

Metabolic Reprogramming via ACOD1 Depletion Enhances Function of Human Induced Pluripotent Stem Cell-Derived CAR-Macrophages in Solid Tumors

[Nature Communications] Scientists found, via a pooled metabolic gene knockout CRISPR screen that KEAP1 and ACOD1 were strong regulators of the pro-inflammatory state in macrophages.

Whole-Genome Screens Reveal Regulators of Differentiation State and Context-Dependent Migration in Human Neutrophils

[Nature Communications] Researchers performed a comprehensive, genome-wide assessment of the molecular factors critical to proliferation, differentiation, and cell migration in a neutrophil-like cell line.

NLGN4X TCR Transgenic T Cells to Treat Gliomas

[Neuro-Oncology] T cell receptor (TCR) discovery was performed using droplet-based single cell TCR sequencing of neuroligin 4 X-linked (NLGN4X)-tetramer-sorted T cells post vaccination.

TLR8 Escapes X Chromosome Inactivation in Human Monocytes and CD4+ T Cells

[Biology of Sex Differences] Investigators conducted a comprehensive single-cell resolution analysis of the transcriptional regulation of both TLR7 and TLR8, in CD14+ monocytes and CD4+ T lymphocytes.

Production of Therapeutic Levels of Human FIX-R338L by Engineered B Cells Using GMP-Compatible Medium

[Molecular Therapy-Methods & Clinical Development] Researchers established an advanced in vitro good manufacturing practice-compatible culturing system characterized by robust and consistent expansion rate, high viability, and efficient B cell differentiation.

Large Extracellular Vesicles Derived from Human Regulatory Macrophages (L-EVMreg) Attenuate CD3/CD28-Induced T Cell Activation In Vitro

[Journal of Molecular Medicine] Scientists investigated whether L-EVMreg also affect the CD3/CD28-mediated activation of T cells. Activation of human T-cells was induced by CD3/CD28-coated beads in the absence or presence of Mreg or different concentrations of L-EVMreg .

Dendritic Cells as Shepherds of T Cell Immunity in Cancer

[Immunity] Investigators review the current understanding of dendritic cell T cell interactions at both priming and effector sites of immune responses.

Spatial Predictors of Immunotherapy Response in Triple-Negative Breast Cancer

[Nature] Researchers investigated the impact of multicellular spatial organization on response, and explored how immune checkpoint blockade remodeled the tumor microenvironment.

Phosphoantigens Glue Butyrophilin 3A1 and 2A1 to Activate Vγ9Vδ2 T Cells

[Nature] Scientists showed how—in both humans and alpaca—multiple phosphoantigens functioned as ‘molecular glues’ to promote heteromeric association between the intracellular domains of BTN3A1 and the structurally similar butyrophilin BTN2A1.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.