Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Anonymous $11 Million Gift to Support and Expand Neurofibromatosis Research at UHN’s Krembil Brain Institute

[University Health Network (Newswise, Inc.)] University Health Network (UHN) Foundation announced an anonymous gift of $11 million in support of neurofibromatosis research.

C2N Diagnostics Introduces P-tau Multi-Analyte Assay for Research Use Only to Advance Alzheimer’s Disease and Brain Health Field

[C2N Diagnostics (Business Wire)] C2N Diagnostics announced its latest innovative offering for enhancing care in brain health: a high-resolution mass spectrometry-based plasma tau multi-analyte assay (p-tau MAA) for Research Use Only.

Myotubularin-Related Phosphatase 5 Is a Critical Determinant of Autophagy in Neurons

[Current Biology] Scientists sampled nascent transcript synthesis and stabilities in fibroblasts, induced pluripotent stem cells (iPSCs), and iPSC-derived neurons, thereby uncovering a neuron-specific stability of transcripts encoding myotubularin-related phosphatase 5.

Neuron-Astrocyte Transmitophagy Is Altered in Alzheimer’s Disease

[Neurobiology of Disease] The authors reported that the internalization of neuronal mitochondria was significantly increased in astrocytes isolated from Alzheimer's disease mouse brains.

Apolipoprotein C1 Promotes Glioblastoma Tumorigenesis by Reducing KEAP1/NRF2 and CBS-Regulated Ferroptosis

[Acta Pharmacologica Sinica] Researchers investigated the role of apolipoprotein C1 (APOC1) in glioblastoma (GBM) tumorigenesis. Using in silico assays they showed that APOC1 was highly expressed in GBM tissues and its expression was closely related to GBM progression.

Ammonia Induces Amyloidogenesis in Astrocytes by Promoting Amyloid Precursor Protein Translocation into the Endoplasmic Reticulum

[Journal of Biological Chemistry] Researchers reported that hyperammonemia increased the amount of mature amyloid precursor protein in astrocytes, and promoted amyloid beta production.

MicroRNA-27a-3p Delivered by Extracellular Vesicles from Glioblastoma Cells Induces M2 Macrophage Polarization via the EZH1/KDM3A/CTGF Axis

[Cell Death Discovery] The isolated glioblastoma-extracellular vesicles (GBM-EVs) were co-cultured with macrophages. After co-culture under normoxia/hypoxia, the effect of EV-derived hsa-miR-27a-3p on GBM cell biological processes was analyzed.

High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes

[Frontiers in Genetics] Scientists examined changes at the transcriptome level to explore the effects of amyloid beta and senescence on astrocytes.

F-Box Protein 11 Suppresses Cell Proliferation and Aerobic Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation of Cdc25A

[Journal of Neuropathology and Experimental Neurology] MTT and colony formation assays and enzyme linked immunosorbent assay, ELISA, demonstrated that overexpression of F-box protein 11 suppressed proliferation and aerobic glycolysis and induced cell cycle arrest in U251-MG and A172 cells.

Neuroprotective Effect of Ginsenoside Re against Neurotoxin-Induced Parkinson’s Disease Models via Induction of Nrf2

[Molecular Medicine Reports] Investigators examined the neuroprotective effects of a panel of active components of ginseng and explored their molecular mechanisms of action in two rotenone‑induced models of Parkinson's disease.

Glial-Neuron Crosstalk in Health and Disease: A Focus on Metabolism, Obesity, and Cognitive Impairment

[Neurobiology of Disease] Investigators focus on the metabolic crosstalk between the three major glial cell types, oligodendrocytes, astrocytes, and microglia, with neurons under physiological conditions.

Sernova and Evotec Enter into an Exclusive Global Strategic Partnership for iPSC-Based Beta Cell Replacement Therapy to Develop and Commercialize a ‘Functional Cure’ for...

[Sernova Corp. (GlobeNewswire, Inc.)] Sernova Corp. and Evotec SE announced an exclusive global strategic partnership to develop a best-in-class cell therapy treatment for people living with insulin-dependent diabetes.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.