Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
The Dual Role of PGAM5 in Inflammation
[Experimental & Molecular Medicine] The authors provide crucial insights to guide the development of intelligent therapeutic strategies targeting phosphoglycerate mutase family member 5 (PGAM5)-specific regulation to treat intractable inflammatory conditions, as well as the potential extension of its broader application to other diseases to achieve more precise and effective treatment outcomes.
HCW Biologics Granted FDA Clearance to Evaluate One of the Company’s Lead Product Candidates in a First-In-Human Phase 1 Clinical Trial
[HCW Biologics, Inc.] HCW Biologics, Inc. announced that it has received clearance for its Investigational New Drug Application from the US FDA to initiate a first-in-human Phase I dose escalation clinical trial to evaluate one of its lead drug candidates, HCW9302, in patients with moderate-to-severe alopecia areata, a common autoimmune disease in humans that currently has no curative FDA approved treatments.
Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarization in Relapsed Melanoma
[Journal For Immunotherapy of Cancer] Researchers identified a robust PARP14 catalytic inhibitor gene signature and evaluated its association with patient survival. Using preclinical models and single-cell RNA sequencing, they investigated immune and tumor cell adaptations to PARP14 inhibition combined with programmed cell death 1 blockade.
MAPK Pathway Activating Alteration and Immunotherapy Efficacy in Squamous Cell Lung Carcinoma: Results from the Randomized, Prospective SQUINT Trial
[Clinical Cancer Research] This randomized, Phase II SQUINT trial assessed the efficacy of nivolumab plus ipilimumab versus platinum-based chemotherapy plus nivolumab and to identify clinically available biomarkers of response to immunotherapy in patients with advanced or metastatic lung squamous cell carcinoma.
Integrative Genomic Analysis of DLBCL Identifies Immune Environments Associated with Bispecific Antibody Response
[Blood] An integrative, multi-omic approach was applied to multiple large independent datasets in order to characterize diffuse large B-cell lymphoma (DLBCL) immune environments, and to define their association with tumor cell-intrinsic genomic alterations and outcomes to CD19-directed CAR T-cell and CD20 x CD3 BsAb therapies.
Thigh Injections of Cabotegravir + Rilpivirine in Virally Suppressed Adults With Human Immunodeficiency Virus Type 1: A Substudy of the Phase 3b ATLAS-2M Study
[Clinical Infectious Diseases] Investigators presented substudy results on short-term repeat intramuscular cabotegravir + rilpivirine long-acting thigh injections in participants with ≥3 years of experience with gluteal administration during the ATLAS–2M study.
Rapamycin-Resistant Polyclonal Th1/Tc1 Cell Therapy (RAPA-201) Safely Induces Disease Remissions in Relapsed, Refractory Multiple Myeloma
[Journal For Immunotherapy of Cancer] The clinical trial evaluated RAPA-201 therapy in combination with fludarabine-sparing low-dose host conditioning for the treatment of patients with relapsed, refractory multiple myeloma.
SELP+ TEC:CD8+ T Cell Crosstalk Associates with Improved Radiotherapy Efficacy in Cervical Cancer
[Molecular Cancer] Scientists analyzed tumor tissue samples from 205 cercial cancer patients undergoing radiotherapy, scRNA-seq data from 42,159 cells of eight patients, and bulk RNA-sequencing data from 187 radiotherapy-treated patients.
Spatially Mapping the Tumour Immune Microenvironments of Non-Small Cell Lung Cancer
[Nature Communications] Researchers applied imaging mass cytometry to a balanced cohort of lung adenocarcinoma and lung squamous cell carcinoma patients, matched for clinical factors such as age, sex, and smoking history, to analyze 204 histopathology images of tumours from 102 individuals with non-small cell lung cancer.
Boosting Human Immunology: Harnessing the Potential of Immune Organoids
[EMBO Molecular Medicine] The authors discuss recent advances in versatile human tonsil/adenoid tissue-based ex vivo immune organoid cultures as well as related cancer and autoimmunity-focused experimental setups.
Allogene Therapeutics Secures U.S. FDA IND Clearance for ALLO-329, Advancing its Next-Generation Allogeneic CAR T into Autoimmune Diseases
[Allogene Therapeeutics, Inc.] Allogene Therapeutics, Inc. announced that the US FDA has cleared its Investigational New Drug application for a rheumatology basket study of ALLO-329, an investigational allogeneic CAR T product.
Clone-Resolved Chemical Depletion of T cells via Cellular Proximity Chemistry
[Angewandte Chemie-International Edition] Using engineered dendritic cells with surface-bound photosensitizers, researchers generated reactive oxygen species at immune synapses, leading to the targeted death of antigen-specific T cells in close proximity.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.