Category Archives: Human Immunology

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industry & policy

Pfizer’s Abrocitinib Receives Positive CHMP Opinion for the Treatment of Adults with Moderate to Severe Atopic Dermatitis

Pfizer, Inc. announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use has adopted a positive opinion recommending the 100 mg and 200 mg doses of abrocitinib, an oral, once-daily, Janus kinase 1 inhibitor, for marketing authorization to treat moderate to severe atopic dermatitis in adults who are candidates for systemic therapy.

[Pfizer, Inc.]

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Press Release

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industry & policy

Bristol Myers Squibb Receives Positive CHMP Opinion for Zeposia (Ozanimod) as a Treatment for Adult Patients with Moderately to Severely Active Ulcerative Colitis

Bristol Myers Squibb announced the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended approval of Zeposia for the treatment of adults with moderately to severely active ulcerative colitis who have had an inadequate response, lost response, or were intolerant to either conventional therapy or a biologic agent.

[Bristol Myers Squibb]

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Press Release

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Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy

Scientists demonstrated the first application of label-free Raman spectroscopy for elucidating biomolecular changes induced by anti-CTLA-4 and anti-PD-L1 immune checkpoint inhibitors in the tumor microenvironment of colorectal tumor xenografts.

[Cancer Research]

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Abstract

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Therapeutically Expanded Human Regulatory T-cells Are Super-Suppressive Due to HIF1A Induced Expression of CD73

Scientists demonstrated that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha driven acquisition of CD73 expression.

[Communications Biology]

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Differential Expression Profile of Gluten-Specific T Cells Identified by Single-Cell RNA-Seq

In this first single-cell RNA-seq study of tetramer-sorted T cells from untreated celiac disease patients blood, investigators found that gluten-specific T cells showed distinct transcriptomic profiles consistent with activated effector memory T cells that shared features with Th1 and follicular helper T cells.

[PLOS ONE]

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Differential Levels of mRNAs in Normal B Lymphocytes, Monoclonal B Lymphocytosis and Chronic Lymphocytic Leukemia Cells from the Same Family Identify Susceptibility Genes

Researchers hypothesized that progressive changes in gene expression resulted in malignant transformation of B lymphocytes to family histroy of monoclonal B lymphocytosis, and subsequent alterations in gene expression occur before overt family history of chronic lymphocytic leukemia develops.

[Oncology and Therapy]

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CD73-Mediated Adenosine Production by CD8 T Cell-Derived Extracellular Vesicles Constitutes an Intrinsic Mechanism of Immune Suppression

The authors showed that extracellular vesicles isolated from the synovial fluid of patients with juvenile idiopathic arthritis contribute to T cell suppression in a CD73-dependent manner.

[Nature Communications]

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Abstract Graphical Abstract

Costimulation Molecules Differentially Regulate the ERK-Zfp831 Axis to Shape T Follicular Helper Cell Differentiation

The authors found that phorbol 12-myristate 13-acetate + ionomycin stimulation, together with interleukin-6, potently induced T follicular helper cell-like transcriptomic programs in vitro.

[Immunity]

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Prognostic Implications of Tumor-Infiltrating T Cells in Early-Stage Endometrial Cancer

The proportion of T cells and their subpopulations were associated with clinicopathological features and relapse-free survival outcomes. CD3+ CD4+ infiltrates were more abundant in the patients with higher grade or non-endometrioid histology.

[Modern Pathology]

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Abstract

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Genomic and Transcriptomic Correlates of Immunotherapy Response within the Tumor Microenvironment of Leptomeningeal Metastases

To examine the efficacy of immune checkpoint inhibitors in patients with Leptomeningeal disease, researchers completed two Phase II clinical trials.

[Nature Communications]

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