Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Generation of Functional Thymic Organoids From Human Pluripotent Stem Cells

[Stem Cell Reports] Researchers showed the generation of thymic epithelial cells in vitro in isogenic stem cell-derived thymic organoids, consisting of thymic epithelial progenitors, hematopoietic progenitor cells, and mesenchymal cells, differentiated from the same hPSC line.

A Neomorphic Mutation in the Interferon Activation Domain of IRF4 Causes a Dominant Primary Immunodeficiency

[Journal Of Experimental Medicine] The authors reported on a heterozygous interferon regulatory factor 4 (IRF4) missense variant identified in three patients from a multigeneration family with hypogammaglobulinemia, characterizing the immunological consequences of this neomorphic mutation.

IFN-γ Signature Enables Selection of Neoadjuvant Treatment in Patients with Stage III Melanoma

[Journal Of Experimental Medicine] Patients with stage III melanoma and high intra-tumoral interferon-γ (IFN-γ) scores were randomized to neoadjuvant nivolumab or nivolumab + domatinostat, while patients with low IFN-γ scores received nivolumab + domatinostat or ipilimumab + nivolumab + domatinostat.

Pre-Existing Fc Profiles Shape the Evolution of Neutralizing Antibody Breadth following Influenza Vaccination

[Cell Reports Medicine] Scientists applied a systems approach to profile hemagglutinin- and neuraminidase-specific humoral signatures that track with the evolution of broad immunity in a cohort of vaccinated individuals and validated these findings in a second longitudinal cohort.

Immune Landscape in Invasive Ductal and Lobular Breast Cancer Reveals a Divergent Macrophage-Driven Microenvironment

[Nature Cancer] To investigate the immunobiology of ER+ breast cancer in women with invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC), scientists performed phenotypic, transcriptional, and functional analyses for a cohort of treatment-naive IDC and ILC tumors.

Immune Subset-Committed Proliferating Cells Populate the Human Foetal Intestine throughout the Second Trimester of Gestation

[Nature Communications] Investigators showed the immune subset composition of the human fetal intestine during development, by longitudinal spectral flow cytometry analysis of samples between 14 and 22 weeks of gestation.

Combined Disruption of T Cell Inflammatory Regulators Regnase-1 and Roquin-1 Enhances Antitumor Activity of Engineered Human T Cells

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers targeted a regulatory axis of T cell inflammatory responses, Regnase-1 and Roquin-1, to enhance antitumor responses in human T cells engineered with two clinical-stage immune receptors.

Human T Cell Generation Is Restored in CD3δ Severe Combined Immunodeficiency through Adenine Base Editing

[Cell] Delivery of mRNA encoding a laboratory-evolved adenine base editing and guide RNA into a CD3δ severe combined immunodeficiency patient’s hematopoietic stem and progenitor cells resulted in a 71.2% ± 7.85% correction of the pathogenic mutation.

Isoform-Specific Knockdown of Long and Intermediate Prolactin Receptors Interferes with Evolution of B-Cell Neoplasms

[Communications Biology] In overt human B-cell malignancies, knockdown of the long plus intermediate isoforms of the PRL receptor (LF/IFPRLR) reduced B-cell viability and their MYC and BCL2 expression, and reduced the growth of human B-cell malignancies in vitro and in vivo.

Stepwise Activities of mSWI/SNF Family Chromatin Remodeling Complexes Direct T Cell Activation and Exhaustion

[Molecular Cell] Researchers comprehensively profiled the genomic occupancy of mSWI/SNF chromatin remodeling complexes throughout acute and chronic T cell stimulation, finding that stepwise changes in localization over transcription factor binding sites directed site-specific chromatin accessibility and gene activation leading to distinct phenotypes.

B Cells in the Tumor Microenvironment: Multi-Faceted Organizers, Regulators, and Effectors of Anti-Tumor Immunity

[Cancer Cell] The authors summarize our current understanding of tumor-infiltrating lymphocyte-B cells and plasma cells in human cancer, highlighting the compelling therapeutic opportunities offered by their unique tumor recognition and effector mechanisms.

Clonal Hematopoiesis and Dysregulation of the Immune System

[Nature Reviews Immunology] Scientists review the observational and mechanistic studies describing the connection between clonal hematopoiesis (CH) and pathological immune dysfunction, the effects of CH-associated genetic alterations on the function of myeloid and lymphoid cells, and the clinical and therapeutic implications of CH as a target for immunomodulation.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.