Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Hyaluronic Acid-CD44 Signaling Defines Therapeutic Resistance and Immunosuppressive Microenvironment in Peritoneal Metastasis of Gastric Cancer

March 13, 2026

[Journal for Immunotherapy of Cancer] In both patient-derived samples and mouse models, CD44 blockade reduces Treg abundance, restores cytotoxic T cell activity, and enhances the therapeutic response to anti-PD-1 treatment.

Clinical Development of Cancer Vaccines

March 13, 2026

[Nature Medicine] The authors highlight insights from recent clinical trials, translational studies and preclinical models, which reveal critical factors for optimizing cancer vaccines.

Natural Maternal Immunity Protects Neonates from Escherichia Coli Sepsis

March 13, 2026

[Nature] Scientists show that newborn babies with E. coli sepsis have selectively reduced vertically transferred natural antibodies that recognize E. coli sepsis, mechanistically explaining their susceptibility to infection.

B Cell Imprinting in Children Impairs Antibodies to the Haemagglutinin Stalk

March 11, 2026

[Nature] To understand the basis and impact of imprinting by influenza A viruses, scientists characterized the B cell responses of young children after consecutive first infections with divergent H1N1 and H3N2 strains of influenza.

Major Grant for Research into Autoimmunity and Cancer

March 10, 2026

[Uppsala University] Does autoimmunity play a role in the development of cancer? Why is it that some people with an increased risk of developing cancer never do? Dr. Nils Landegren is part of an international team of researchers that has been awarded the equivalent of SEK 225 million through the Cancer Grand Challenges research initiative to study this.

New NIH Grant Advances Lupus Protein Research

March 10, 2026

[University of Oklahoma] A $1.7 million grant from the National Institutes of Health will allow a University of Oklahoma researcher to continue investigating a protein that may help explain why lupus develops and how it might be treated more precisely.

Immune-Mediated Side Effects of Cancer Immunotherapies

March 10, 2026

[Blood] Recent data have led to a better understanding of the role of myeloid cells and T cells, including tissue-resident T-cells, in the pathophysiology of graft-versus-host disease, CAR-T cell associated immunotoxicities and immune-related adverse events.

Cytotoxic CD4+ T Cells: Origin, Biological Functions, Diseases, and Therapeutic Targets

March 10, 2026

[Signal Transduction and Targeted Therapy] Cytotoxic CD4+ T lymphocytes play pivotal roles across a broad spectrum of diseases, including cancer, infectious diseases, autoimmune disorders, and cardiovascular diseases.

Immune-Microbiome Coordination Defines Interferon Setpoints in Healthy Humans

March 10, 2026

[Cell] Investigators performed multi-omic profiling of 110 healthy participants through the ImmunoMicrobiome study. They generated multimodal data of the immune system, microbiome, and metabolome as a resource for the field.

Human Anti-Glycan Reactivity Emerges from B Cells Utilizing Private Gene Rearrangements That Are Affinity Maturated in Germinal Centers

March 10, 2026

[Immunity] Researchers examined the ontogeny and diversity of the human anti-glycan repertoire. Antibodies reactive with group A Streptococcus cell wall carbohydrate (GAC) were absent at birth but reached adult frequencies in childhood, concomitant with the emergence of circulating GAC-reactive memory B cells.

Discovery of an ITK and TRK Kinase Inhibitor for the Potential Topical Treatment of Atopic Dermatitis

March 10, 2026

[Nature Communications] Scientists described PF-07245303, a compound which potently inhibits IL-2-inducible T cell kinase and tropomyosin-related kinase family kinases capable of inhibiting T cell receptor-mediated cytokine production from CD4 and CD8 T cells and suppressing nerve growth factor-induced human basophil activation.

Five Global Teams Awarded $125 Million to Take on the Toughest Challenges at the Frontiers of Cancer Science

March 6, 2026

[Cancer Grand Challenges (Business Wire)] Cancer Grand Challenges, a global initiative co-founded by the National Cancer Institute in the US and Cancer Research UK, announced a major $125m commitment to propel cancer research into uncharted territory.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.