Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

MU Researcher Awarded €400,000 for Obesity-Related Research

September 19, 2024

[Maynooth University] Dr. Andrew Hogan of Maynooth University’s (MU) Department of Biology has been awarded funding of over €400,000 for research on targeting iron to boost immune function in obesity and improve patient outcomes.

HLA A*24:02–Restricted T Cell Receptors Cross-Recognize Bacterial and Preproinsulin Peptides in Type 1 Diabetes

September 18, 2024

[Journal of Clinical Investigation] Combinatorial peptide library screening was used to produce a preferred peptide recognition landscape for a patient-derived T cell receptor that recognized the preproinsulin-derived peptide sequence LWMRLLPLL in the context of disease risk allele HLA A*24:02.

Deficiency of MTlr7 and Irf7 in Mice Increases the Severity of COVID-19 through the Reduced Interferon Production

September 18, 2024

[Communications Biology] Scientists utilized toll-like receptor 7 (Tlr7) and IFN regulatory factor 7 (Irf7) deficiency mice, single-cell RNA analysis, and bone marrow transplantation approaches to study the association between deficiency-accelerated severe COVID-19 and reduced production of interferons.

S100A9 and HMGB1 Orchestrate MDSC-Mediated Immunosuppression in Melanoma through TLR4 Signaling

September 17, 2024

[Journal for ImmunoTherapy of Cancer] Myeloid-derived suppressor cell were isolated from the peripheral blood of patients with advanced melanoma or generated in vitro from healthy donor-derived monocytes.

Safety and Antiviral Effect of a Triple Combination of HIV-1 Broadly Neutralizing Antibodies: A Phase I/IIa Trial

September 17, 2024

[Nature Medicine] Scientists performed an open-label, two-part study evaluating a single intravenous dose of HIV-1 bNAbs, PGT121, PGDM1400 and VRC07-523LS, in six adults without HIV in part 1 and a multicenter trial of up to six monthly infusions of these three bNAbs in 12 people living with HIV with an antiretroviral therapy interruption in part 2.

Peripheral Blood–Derived PD-1/CD28–CD19-CAR–Modified PD-1+ T Cell Therapy in Patients with Solid Tumors

September 17, 2024

[Cancer Immunology Research] Single-cell RNA sequencing analysis showed that PD-1+ T cells from peripheral blood (PB) highly expressed cytotoxicity-related genes and were enriched for T cell activation–related pathways compared with PD-1– T cells from PB or tumor tissues.

The Complexity of Immune Evasion Mechanisms throughout the Metastatic Cascade

September 17, 2024

[Nature Immunology] Scientists explore the complexities of immune escape mechanisms used throughout the metastatic cascade to promote tumor cell dissemination and affect organotropism.

ERC Starting Grant: 1.6 Million Euros for Jakob Zimmermann

September 17, 2024

[Universität Würzburg] Immunology researcher Dr Jakob Zimmermann received a prestigious grant from the European Research Council (ERC) for his research project. Since September 2024, the scientist has been strengthening the Institute of Systems Immunology at Julius-Maximilians-Universität Würzburg with his own team.

CD36-Mediated Ferroptosis Destabilizes CD4+ T Cell Homeostasis in Acute Stanford Type-A Aortic Dissection

September 16, 2024

[Cell Death & Disease] Whole transcriptome profiles showed that ferroptosis and lipid binding pathways were enriched in CD4+ T cells.

TNFSF14+ Natural Killer Cells Prevent Spontaneous Abortion by Restricting Leucine-Mediated Decidual Stromal Cell Senescence

September 13, 2024

[EMBO Journal] Investigators performed single-cell RNA transcriptomics on endometrial stromal cells and decidual stromal cells and found that cell senescence during decidualization was accompanied by increased levels of the branched-chain amino acid transporter SLC3A2.

CD98hc Promotes Drug Resistance in Extranodal Natural Killer/T Cell Lymphoma through Tumor Cell–Derived Small Extracellular Vesicles

September 13, 2024

[Science Signaling] Scientists showed that high abundance of the transmembrane glycoprotein CD98hc in tumor cells and serum small extracellular vessicles was associated with extranodal natural killer/T cell lymphoma progression and drug resistance.

ISB 2001 Trispecific T Cell Engager Shows Strong Tumor Cytotoxicity and Overcomes Immune Escape Mechanisms of Multiple Myeloma Cells

September 13, 2024

[Nature Cancer] To determine an optimal first-in-human dose for the ongoing clinical trial of evaluating safety and anti-myeloma activity of ISB 2001 in participants with relapsed/refractory multiple myeloma, researchers developed an innovative quantitative systems pharmacology model leveraging preclinical data.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.