Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Dr. Gabriel Rabinovich Receives the 5th FERO Dr Baselga Grant

June 16, 2026

[CaixaResearch Institute] Dr. Gabriel Rabinovich has been awarded the 5th FERO Dr Baselga Grant. The project will focus on pancreatic ductal adenocarcinoma and explore how the tumor microenvironment interferes with the immune system’s ability to respond effectively.

UNK Professor Joe Dolence Receives $500,000 Grant for Peanut Allergy Research

June 16, 2026

[UNK News] University of Nebraska (UNK) at Kearney associate biology professor Dr. Joe Dolence has received a National Institutes of Health grant. The grant provides $500,000 to support research examining why males and females respond differently to peanut allergens and how those differences may influence the development of peanut allergies.

Functional and Dysfunctional T Regulatory Cell States in Human Tissues in RA and Other Autoimmune Arthritic Diseases

June 16, 2026

[Nature Immunology] Researchers used single-cell RNA sequencing to analyze regulatory T cells (Treg) in synovial tissues from patients with rhuematoid arthiriits. They identified two predominant Treg states, CD25hiCXCR6pos Treg cells and dysfunctional CD25loAREGpos Treg cells, both enriched in synovial tissues but not in blood.

Reprogramming the Tumor Microenvironment via TFF3 Targeting: A Potential Novel Avenue to Boost CAR-T Cell Therapy in Solid Tumors

June 16, 2026

[Cancer Gene Therapy] The authors explore how TFF3 signaling contributes to tumor progression and immune escape, and how its inhibition might reshape the tumor microenvironment (TME) to better support CAR-T cell activity

Single-Cell Map of the Healthy Human Immune System across the Lifespan Reveals Unique Infant Immune Signatures

June 16, 2026

[Nature Communications] Scientists profiled PBMCs from 167 healthy individuals, infants, children, adolescents, young adults, middle‑aged, older adults and oldest old using scRNA‑seq and snATAC‑seq. They provide insight into human immune system dynamics across the human lifespan, emphasizing unique features of the infant immune system.

Immune Responses in Aging Adults

June 16, 2026

[Journal of Clinical Investigation] Adaptive immune function declines with age through coordinated cellular and molecular programs. T and B lymphocytes exhibit a decline in naive cells, progressive loss of stemness, shortened lifespan, and constrained clonal diversity.

SATB1 Is a Targetable Modulator of JAK-STAT Signaling and Cytokines in Human Treg and Tconv Cells

June 16, 2026

[EMBO Reports] Scientists described SATB Homeobox 1 (SATB1)-regulated gene signatures as largely subset-specific, with broader effects on regulatory T cells (Treg) cells. SATB1 knockout reduces suppressive capacities of human Treg cells but boosts tumor clearance via CD4 CAR T cells in a preclinical model.

Perturbation of the Preterm Human Immune System in Early Life

June 16, 2026

[JCI Insight] Researchers investigated whether severe bronchopulmonary dysplasia and systemic infection, 2 major complications of prematurity, produce distinct immune signatures and change immune composition over time.

Clonal Lineage Tracing of Innate Immune Cells in Human Cancer

June 16, 2026

[Cancer Cell] Investigators described a method leveraging somatic mitochondrial DNA mutations to reconstruct clonal lineage relationships between cells in native human tissues.

Hallmarks and Correlates of Effective Adoptive Cell Immunotherapy for Cancer

June 8, 2026

[Nature Reviews Immunology] Scientists highlight emerging correlates of response to adoptive cell transfer and novel strategies that integrate tumor immunology, cancer genomics, computational biology, and T cell engineering for the development of next-generation cellular immunotherapies.

Aging Restricts Maturation of CXCL13 T Follicular Helper Cells in Human Immunity

June 5, 2026

[Cell Reports] Using human tonsil organoids, single-cell RNA sequencing, and CRISPR perturbations, researchers mapped age-associated changes in T follicular helper cells, the cell type that provides help to B cells in germinal centers.

Anixa Biosciences Strengthens International Patent Protection for Ovarian Cancer Vaccine Technology with Canadian Notice of Allowance

June 3, 2026

[ Anixa Biosciences, Inc.] Anixa Biosciences, Inc. announced that the Canadian Intellectual Property Office has issued a Notice of Allowance for a patent covering key aspects of Anixa's ovarian cancer vaccine technology. Anixa's ovarian cancer vaccine is based on immunizing against AMHR2, a protein expressed in normal ovaries prior to menopause and also aberrantly expressed in certain types of ovarian cancer.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.