Integrated Diagnosis Based on Transcriptome Analysis in Suspected Pediatric Sarcomas

To evaluate the potential utility of including RNA-sequencing in the diagnostic process, investigators performed RNA-sequencing in 47 patients with suspected pediatric sarcomas.
[npj Genomic Medicine]
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A Chondrosphere-Based Scaffold Free Approach to Manufacture an In Vitro Articular Cartilage Model

Human articular chondrocytes and immortalised mesenchymal cells differentiated in chondrocytes were cultured in round-bottom 96-well plates to produce multicellular spheroids and their growth kinetics and viability was evaluated over seven days of culture.
[Tissue Engineering Part A]
Scalzone, A., Wang, X. N., Dalgarno, K., Ferreira-Duarte, A. M., & Gentile, P. (2021). A chondrosphere-based scaffold free approach to manufacture an in-vitro articular cartilage model. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2021.0061 Cite
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Immune Modulation via Adipose Derived Mesenchymal Stem Cells Is Driven by Donor Sex In Vitro

The authors examined the potency and functionality of both female and male adipose derived mesenchymal stem cells in order to gain further insights into donor selection.
[Scientific Reports]
Mckinnirey, F., Herbert, B., Vesey, G., & McCracken, S. (2021). Immune modulation via adipose derived Mesenchymal Stem cells is driven by donor sex in vitro. Scientific Reports, 11(1), 12454. https://doi.org/10.1038/s41598-021-91870-4 Cite
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Therapeutic Effect of IL1β Priming Tonsil Derived-Mesenchymal Stem Cells in Osteoporosis

IL1β priming Tonsil-derived MSCs had an enhanced osteogenic differentiation and secreted factors that regulate both osteoclastogenesis and osteoblastogenesis.
[Tissue Engineering and Regenerative Medicine]
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T-Regulatory Cells Predict Clinical Outcome in Soft Tissue Sarcoma Patients: A Clinico-Pathological Study

Investigators analyzed tumor-infiltrating lymphocytes and immune checkpoint molecules in soft tissue sarcomas, and assessed their prognostic impact regarding local recurrence, distant metastasis, and overall survival.
[British Journal of Cancer]
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STAG2 Loss Rewires Oncogenic and Developmental Programs to Promote Metastasis in Ewing Sarcoma

The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological role is less clear. The authors demonstrated that cohesin complexes containing STAG2 occupy enhancer and polycomb repressive complex-marked regulatory regions.
[Cancer Cell]
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Essent Biologics Launches Human Mesenchymal Stem Cells for Regenerative Medicine, Biopharmaceutical and Cell Therapy Research

Essent Biologics has announced the launch of its human MSCs for regenerative medicine, biopharmaceutical and cell therapy research. Essent Biologics will provide highly-characterized, low-passaged human MSCs.
[Essent Biologics]
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Mesenchymal Stromal Cell-Derived Exosomes in Cardiac Regeneration and Repair

Scientists summarize the potential mechanisms and therapeutic effects of MSC-derived exosomes in cardiac regeneration and repair and provide evidence to support their clinical application.
[Stem Cell Reports]
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Senolytics Improve Bone Forming Potential of Bone Marrow Mesenchymal Stem Cells from Aged Mice

By using a calvarial defect model, scientists showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged bone marrow MSC both in vitro and in vivo.
[npj Regenerative Medicine]
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Tailored Generation of Insulin Producing Cells from Canine Mesenchymal Stem Cells Derived from Bone Marrow and Adipose Tissue

Researchers investigated insulin-producing cell generation from two practical canine MSCs, canine bone marrow-derived MSC, and canine adipose-derived MSCs.
[Scientific Reports]
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Mesenchymal Stromal (Stem) Cell (MSC) Therapy Modulates miR-193b-5p Expression to Attenuate Sepsis-Induced Acute Lung Injury

The authors showed that treatment with MSCs decreased expression of host-derived miR-193b-5p and increased expression of its target gene, the tight junctional protein occludin, in lungs from septic mice.
[European Respiratory Journal]
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