Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Engineered Bone Marrow as a Clinically Relevant Ex Vivo Model for Primary Bone Cancer Research and Drug Screening

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors adapted a previously described engineered bone marrow construct for use as a three-dimensional platform to study how microenvironmental and immune factors affect osteosarcoma tumor progression.

δ-Tocotrienol Preconditioning Improves the Capability of Bone Marrow-Derived Mesenchymal Stem Cells in Promoting Wound Healing by Inhibiting BACH1-Related Ferroptosis

[Cell Death Discovery] Investigators explored the role of δ-Tocotrienol in bone marrow-derived MSC ability of wound healing. Transcriptome and single-cell analysis were used to explore the genes and pathways related to ferroptosis in wound tissues.

Therapeutic Potential of Oral-Derived Mesenchymal Stem Cells in Retinal Repair

[Stem Cell Reviews And Reports] Researchers comprehensively explored the potential of various types of stem cells from oral cavity as promising therapeutic options in retinal regeneration.

Adipose-Derived Mesenchymal Stem Cells -Conditioned Medium Effects on Glioma U87 Migration, Apoptosis, and Gene Expression

[Tissue and Cell] Using flow cytometry, adipose tissue-derived MSCs were identified, verified, and their conditioned media was used to treat U87 cells. Through RT-qPCR, scratch assay, and apoptosis analysis, scientists evaluated gene expression, cell migration, and apoptosis in U87 cells.

A CCL2+DPP4+ Subset of Mesenchymal Stem Cells Expedites Aberrant Formation of Creeping Fat in Humans

[Nature Communications] Investigators characterized creeping fat as pro-adipogenic and pro-fibrotic. Lipidomics analysis of Crohn’s disease patients and healthy controls revealed abnormal lipid metabolism in creeping fat.

Human Macrophage Migration Inhibitory Factor Potentiates Mesenchymal Stromal Cell Efficacy in a Clinically Relevant Model of Allergic Asthma

[Molecular Therapy] Scientists investigated the efficacy of human MSCs in high vs low human macrophage migration inhibitory factor (hMIF) environments and the impact of MIF pre-licensing of MSCs using humanized MIF mice in a clinically relevant house dust mite model of allergic asthma.

The Anti-Inflammatory Effects of Mesenchymal Stem Cells Attenuate Diffuse Pulmonary Hemorrhage

[Biotechnology Journal] Therapeutic effects of MSCs/MSC-extracellular vesicles in pristane-induced diffuse pulmonary hemorrhage (DPH) mice were evaluated via pulmonary function testing and histopathology. Transcriptome sequencing analyzed differentially expressed genes in control, DPH, and MSC groups.

Sertoli Cell–Conditioned Medium Induces Differentiation of Bone Marrow–Derived Mesenchymal Stem Cells to Male Germ-Like Cells in Busulfan-Induced Azoospermic Mouse Model

[Reproductive Sciences] The authors co-transplanted bone marrow MSCs with Sertoli cell–conditioned medium into the testis of azoospermic mice.

Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Mediated Delivery of Tetramethylpyrazine Attenuate Cerebral Ischemic Injury

[Journal Of Stroke & Cerebrovascular Diseases] The exosomes (Exos) were extracted by ultracentrifugation and tetramethylpyrazine (TEP) was loaded into the Exos by electroporation. Oxygen-glucose deprivation induced-primary cortical neurons and middle cerebral artery occlusion-induced mouse models were used to determine the effect of Exo-TEP on cerebral ischemic injury in vitro and in vivo.

Extracellular Matrix-Induced Signaling Pathways in Mesenchymal Stem/Stromal Cells

[Cell Communication and Signaling] The authors consider the existing evidence regarded the contribution of extracellular matrix-induced intracellular signaling pathways into the regulation of stem cell differentiation focusing on MSCs as well-studied type of postnatal stem cells totally depended on signals from ECM.

Seven Faculty Members Inducted as Fellows of the Canadian Academy of Health Sciences

[UBC Faculty of Medicine] Seven members of the UBC Faculty of Medicine are among 48 new Fellows elected into the Canadian Academy of Health Sciences for 2023.

Effect of Once Versus Twice Intracoronary Injection of Allogeneic-Derived Mesenchymal Stromal Cells After Acute Myocardial Infarction: BOOSTER-TAHA7 Randomized Clinical Trial

[Stem Cell Research & Therapy] Scientists compared the effects of single versus double transplantation of Wharton’s jelly mesenchymal stromal cells on left ventricular ejection fraction post-acute myocardial infarction.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.