Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Enrichment of Oral-Derived Bacteria in Inflamed Colorectal Tumors and Distinct Associations of Fusobacterium in the Mesenchymal Subtype

[Cell Reports Medicine] Across consensus molecular subtypes (CMSs), integration of Fusobacterium animalis (Fa) presence and tumor expression reveals that Fa has the most significant associations in mesenchymal CMS4 tumors despite a lower prevalence than in immune CMS1.

Extracellular Vesicles from Hypoxia-Pretreated Adipose-Derived Stem Cells Regulate Hypoxia/Reoxygenation-Induced Human Dermal Microvascular Endothelial Apoptosis and Autophagy In Vitro

[Heliyon] Scientists investigated the effect of exracellular vesicles isolated from hypoxia-pretreated adipose-derived stem cells on human dermal microvascular endothelial cells to attenuate ischemia/reperfusion injury of free skin flaps.

Interleukin-18-Primed Human Umbilical Cord-Mesenchymal Stem Cells Achieve Superior Therapeutic Efficacy for Severe Viral Pneumonia via Enhancing T-Cell Immunosuppression

[Cell Death & Disease] Researchers selected an appropriate cytokine, IL-18, based on the special cytokine expression profile in severe pneumonia of mice induced by H1N1virus to prime human umbilical cord-MSCs in vitro and improved the therapeutic effect of hUC-MSCs in vivo.

Development of Hetero-Cell Type Spheroids via Core–Shell Strategy for Enhanced Wound Healing Effect of Human Adipose-Derived Stem Cells

[Tissue Engineering and Regenerative Medicine] Researchers developed a core–shell structured spheroid with adipose-derived stem cells in the core and human dermal fibroblasts in the outer part of the spheroid. The core–shell structure was formed by continuous centrifugation and spheroid incubation.

A Clinical Feasible Stem Cell Encapsulation Ensures an Improved Wound Healing

[Biomedical Materials] The authors developed a novel biosynsphere technology to encapsulate stem cells in clinically-ready biomaterials with controlled microsphere size.

Bone Biologics Advances Preparations for NB1 Pilot Clinical Trial with Engagement of Contract Research Organization

[Bone Biologics Corporation (BusinessWire, Inc.)] Bone Biologics Corporation announced it has engaged Avania as the contract research organization for the company’s pilot clinical trial with NB1.

Stromal Regulation of the Intestinal Barrier

[Mucosal Immunology] Investigators review novel findings on the emerging role of mesenchymal cells in this process using insights gained from lineage tracing approaches, Cre-based genes deletion and single cells transcriptomics.

Exosomes Derived from Human Amniotic Mesenchymal Stem Cells Facilitate Diabetic Wound Healing by Angiogenesis and Enrich Multiple lncRNAs

[Tissue Engineering And Regenerative Medicine] The effect of exosomes derived from human amniotic MSCs (hAMSC-Exos) on diabetic wound healing were tested by measuring wound closure rates and immunohistochemical staining of CD31.

Transfer of Mesenchymal Stem Cell Mitochondria to CD4+ T Cells Contributes to Repress Th1 Differentiation by Downregulating T-bet Expression

[Stem Cell Research & Therapy] Scientists utilized CD4+ T cells from HNT TCR transgenic mice that develop Th1-like responses upon antigenic stimulation in vitro and in vivo.

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Diabetic Kidney Disease through the NLRP3 Signaling Pathway

[Stem Cells] Researchers co-cultured podocytes and human umbilical cord-MSCs derived exosomes (Exo) under high glucose and injected MSCs-Exo into diabetic mice, then detected the NLRP3 inflammasome both in vitro and in vivo.

Exosomes Derived from Human Adipose Mesenchymal Stem Cells Ameliorate Hepatic Fibrosis by Inhibiting PI3K/Akt/mTOR Pathway and Remodeling Choline Metabolism

[Journal Of Nanobiotechnology] The authors investigated anti-fibrotic efficacy of exosomes derived from human adipose MSCs in vitro and in vivo, and identified important metabolic changes and the detailed mechanism through transcriptomic and metabolomic profiling.

Administration of Stem Cells against Cardiovascular Diseases with a Focus on Molecular Mechanisms: Current Knowledge and Prospects

[Tissue and Cell] The authors explain the application of stem cells, especially iPSCs and mesenchymal stem cells, in the treatment of cardiovascular diseases with a focus on cellular and molecular mechanisms and then discuss the advantages, disadvantages, and perspectives of using this technology in the treatment of these diseases.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.