This in vitro study evaluated the adhesion, proliferation and osteogenic differentiation of adipose derived MSCs (ASCs) seeded on trabecular titanium cages. ASCs adhered, proliferated and produced an abundant extracellular matrix during the 3 weeks of culture.
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Caliogna, L., Bina, V., Botta, L., Benazzo, F. M., Medetti, M., Maestretti, G., Mosconi, M., Cofano, F., Tartara, F., & Gastaldi, G. (2020). Osteogenic potential of human adipose derived stem cells (hASCs) seeded on titanium trabecular spinal cages. Scientific Reports, 10(1), 18284. https://doi.org/10.1038/s41598-020-75385-y Cite
Investigators showed that in patient-derived stromal cells, H3.3-G34W was incorporated into the chromatin and associated with massive epigenetic alterations on the DNA methylation, chromatin accessibility and histone modification level, that caould be partially recapitulated in an orthogonal cell line system by the introduction of H3.3-G34W.
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Lutsik, P., Baude, A., Mancarella, D., Öz, S., Kühn, A., Toth, R., Hey, J., Toprak, U. H., Lim, J., Nguyen, V. H., Jiang, C., Mayakonda, A., Hartmann, M., Rosemann, F., Breuer, K., Vonficht, D., Grünschläger, F., Lee, S., Schuhmacher, M. K., … Plass, C. (2020). Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone. Nature Communications, 11(1), 5414. https://doi.org/10.1038/s41467-020-18955-y Cite
Catalent and BrainStorm Cell Therapeutics Inc. announced an agreement for the manufacture of NurOwn®, BrainStorm’s autologous cellular therapy being investigated for the treatment of amyotrophic lateral sclerosis. NurOwn induces MSCs to secrete high levels of neurotrophic factors known to promote the survival of neurons and neuroprotection.
[Catalent (GlobeNewswire, Inc.)]
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The authors highlight the emerging role of prostate cancer (PCa)-derived extracellular vesicles in reprogramming osteoblasts and support of premetastatic niche formation. They also develop the concept of cancer-associated osteoblasts and outline the potential of PCa cells to acquire an osteoblastic phenotype, termed osteomimicry, as two strategies that PCa utilizes to create a favorable protected niche.
[Trends in Cancer]
The authors discuss key features of the current COVID-19 outbreak, and the rationale for MSC-based therapy in this setting, as well as the limitations associated with this therapeutic approach.
[NPJ Regenerative Medicine]
To evaluate the function of mesenchymal cells located at the large intestinal crypt, scientists established a novel method through which cells were harvested according to the histologic layers of mouse colon, and compared cellular properties between microenvironmental niches, the luminal mucosa and crypts.
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Matsumura, S., Kurashima, Y., Murasaki, S., Morimoto, M., Arai, F., Saito, Y., Katayama, N., Kim, D., Inagaki, Y., Kudo, T., Ernst, P. B., Shimizu, T., & Kiyono, H. (2020). Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation. Scientific Reports, 10(1), 18351. https://doi.org/10.1038/s41598-020-75186-3 Cite
The authors revealed a distinct ossification-related tuberculosis (TB) lung signature, which may be associated with the activation of the BMP/SMAD/RUNX2 pathway in Mtb-infected macrophages that can restrain mycobacterial survival and promote osteogenic differentiation of mesenchymal stem cells.
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Chai, Q., Lu, Z., Liu, Z., Zhong, Y., Zhang, F., Qiu, C., Li, B., Wang, J., Zhang, L., Pang, Y., & Liu, C. H. (2020). Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis. Communications Biology, 3(1), 1–17. https://doi.org/10.1038/s42003-020-01318-0 Cite
Retinoic acid‐related orphan receptor beta (Ror β) was expressed in THP‐1 macrophages and human inflamed dental pulp stem cells during their resting stage. Upregulated expression of Ror β occurred following an anti‐inflammatory stimulus.
[International Endodontic Journal]
Catalent and BrainStorm Cell Therapeutics, Inc announced an agreement for the manufacture of NurOwn®, BrainStorm’s autologous cellular therapy being investigated for the treatment of ALS, also known as Lou Gehrig’s disease or motor neuron disease.
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Scientists found that the T cell subsets and inflammatory molecules were not affected by MSC treatment during the follow-up period. In control patients, a significant decrease was detected only at the Th2 subset, TGF-β1, PGE2, IDO and anti-FcεRI levels on the 14th day of treatment.
[Stem Cell Reviews and Reports]
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Scientists demonstrated that network plasticity independently controls mesenchymal stem cell spreading through a biphasic relationship dependent on cell-intrinsic forces, and this relationship can be shifted by inhibiting actomyosin contractility.
[Proceedings of the National Academy of Sciences of the United States of America]