Treatment with shCCL20-CCR6 Nanodendriplexes and Human Mesenchymal Stem Cell Therapy Improves Pathology in Mice with Repeated Traumatic Brain Injury

Researchers developed a combined nano-cell therapy by using dendrimers complexed with plasmids targeting CCL20 and its sole receptor CCR6 to reduce inflammation followed by human mesenchymal stem cell transplantation.
[Nanomedicine-Nanotechnology Biology and Medicine]
Mayilsamy, K., Markoutsa, E., Das, M., Chopade, P., Puro, D., Kumar, A., … Mohapatra, S. (2020). Treatment with shCCL20-CCR6 nanodendriplexes and human mesenchymal stem cell therapy improves pathology in mice with repeated traumatic brain injury. Nanomedicine: Nanotechnology, Biology and Medicine, 102247. https://doi.org/10.1016/j.nano.2020.102247 Cite
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DLL4 Restores Damaged Liver by Enhancing hBMSC Differentiation into Cholangiocytes

Scientists aimed to determine whether human bone marrow mesenchymal stem cells can differentiate into biliary epithelial cells in vitro and in vivo and to clarify the role of delta-like ligand 4 (DLL4) in restoring damaged liver by enhancing cholangiocyte differentiation.
[Stem Cell Research]
Sun, S., Yuan, L., An, Z., Shi, D., Xin, J., Jiang, J., … Li, J. (2020). DLL4 restores damaged liver by enhancing hBMSC differentiation into cholangiocytes. Stem Cell Research, 47, 101900. https://doi.org/10.1016/j.scr.2020.101900 Cite
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Lung Delivery of MSCs Expressing Anti-Cancer Protein TRAIL Visualized with 89Zr-Oxine PET-CT

Investigators demonstrated 89Zr-oxine labeling and PET-CT imaging as a potential clinical solution for non-invasively tracking MSCTRAIL biodistribution
[Stem Cell Research & Therapy]
Patrick, P. S., Kolluri, K. K., Zaw Thin, M., Edwards, A., Sage, E. K., Sanderson, T., … Kalber, T. L. (2020). Lung delivery of MSCs expressing anti-cancer protein TRAIL visualised with 89Zr-oxine PET-CT. Stem Cell Research & Therapy, 11(1), 256. https://doi.org/10.1186/s13287-020-01770-z Cite
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The Osteogenic Commitment of CD271+CD56+ Bone Marrow Stromal Cells (BMSCs) in Osteoarthritic Femoral Head Bone

Researchers utilised cell sorting and immunohistochemistry to identify a phenotypically-distinct, osteogenically-committed bone marrow stromal cell subset in human osteoarthritis trabecular bone.
[Scientific Reports]
Ilas, D. C., Baboolal, T. G., Churchman, S. M., Jones, W. G., Giannoudis, P. V., Bühring, H.-J., … Jones, E. (2020). The osteogenic commitment of CD271+CD56+ bone marrow stromal cells (BMSCs) in osteoarthritic femoral head bone. Scientific Reports, 10(1), 11145. https://doi.org/10.1038/s41598-020-67998-0 Cite
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Single-Cell RNA Sequencing Reveals that Lung Mesenchymal Progenitor Cells in IPF Exhibit Pathological Features Early in Their Differentiation Trajectory

Using transcriptional entropy as a metric for differentiated state, we found that the least differentiated Idiopathic Pulmonary Fibrosis mesenchymal progenitor cells (MPCs) displayed the largest differences in their transcriptional profile compared to control MPCs.
[Scientific Reports]
Beisang, D. J., Smith, K., Yang, L., Benyumov, A., Gilbertsen, A., Herrera, J., … Bitterman, P. B. (2020). Single-cell RNA sequencing reveals that lung mesenchymal progenitor cells in IPF exhibit pathological features early in their differentiation trajectory. Scientific Reports, 10(1), 11162. https://doi.org/10.1038/s41598-020-66630-5 Cite
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Combinational Therapy with Antibiotics and Antibiotic-Loaded Adipose-Derived Stem Cells Reduce Abscess Formation in Implant-Related Infection in Rats

Scientists evaluated the antimicrobial activity and therapeutic effect of local treatment with antibiotic-loaded adipose-derived stem cells plus an antibiotic in a rat implant-associated infection model.
[Scientific Reports]
Yoshitani, J., Kabata, T., Arakawa, H., Kato, Y., Nojima, T., Hayashi, K., … Tsuchiya, H. (2020). Combinational therapy with antibiotics and antibiotic-loaded adipose-derived stem cells reduce abscess formation in implant-related infection in rats. Scientific Reports, 10(1), 11182. https://doi.org/10.1038/s41598-020-68184-y Cite
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‘Disturbing and Cruel.’ Universities Blast New Visa Rule for International Students

A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
[Science]
Editorial

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US Bars International Students from Online-Only Learning in Fall

Since higher education institutions ended in-person classes in March due to the COVID-19 pandemic, there has been uncertainty over what classes will look like in the fall. Universities will soon have to come up with an answer.
[The Scientist]
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Control the Fate of Human Umbilical Cord Mesenchymal Stem Cells with Dual-Enzymatically Cross-Linked Gelatin Hydrogels for Potential Applications in Nerve Regeneration

Scientists proposed a new dual‐enzymatically cross‐linked and injectable gelatin hydrogel for regulating survival, proliferation and differentiation of human umbilical cord mesenchymal stem cells in three‐dimensional matrix.
[Journal of Tissue Engineering and Regenerative Medicine]
Abstract

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Human Umbilical Cord Mesenchymal Stem Cell Attenuates Renal Fibrosis via TGF-β/Smad Signaling Pathways In Vivo and In Vitro

Researchers investigated the nephron-protective effect of human umbilical cord mesenchymal stem cells on renal fibrosis.
[European Journal of Pharmacology]
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LOXL2 from Human Amniotic Mesenchymal Stem Cells Accelerates Wound Epithelialization by Promoting Differentiation and Migration of Keratinocytes

Investigators observed increased migration and reduced proliferation and differentiation when keratinocytes were co-cultured in media conditioned by human amniotic epithelial cell and human amniotic mesenchymal stem cells.
[Aging-Us]
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Allogeneic Adipose-Derived Stem Cells Promote Ischemic Muscle Repair by Inducing M2 Macrophage Polarization via the HIF -1α/IL -10 Pathway

Scientists found that the ability of RAW264.7 cells to migrate was impaired in hypoxia, whereas coculturing with adipose‐derived mesenchymal stem cells could enhance the migration capacity.
[Stem Cells]
Liu, J., Qiu, P., Qin, J., Wu, X., Wang, X., Yang, X., … Lu, X. (n.d.). Allogeneic adipose-derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF-1α/IL-10 pathway. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3250 Cite
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