Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Human Fetal Membrane-Mesenchymal Stromal Cells Generate Functional Spinal Motor Neurons In Vitro

[iScience] Scientists demonstrated that human fetal membrane-MSCs could give rise to spinal motor neurons, by the sequential exposure to specific factors that induced a neuralization, caudalization and ventralization of undifferentiated cells

Mesenchymal Cell Replacement Corrects Thymus Hypoplasia in Murine Models of 22q11.2 Deletion Syndrome

[Journal of Clinical Investigation] In colony forming assays, the Tbx1neo2/neo2-derived mesenchymal cells had reduced expansion potential, contrasting the normal growth of thymus epithelial cells.

LPS-Pretreatment Adipose-Derived Mesenchymal Stromal Cells Promote Wound Healing in Diabetic Rats by Improving Angiogenesis

[injury-International Journal of the Care of the injured] Researchers investigated the impact of LPS pretreated human adipose-derived MSCs on skin wound healing in diabetic rats.

Ferroptotic MSCs Protect Mice against Sepsis via Promoting Macrophage Efferocytosis

[Cell Death & Disease] Mice were injected intravenously with MSCSPIO at two hours after Escherichia coli infection and sacrificed at different times to investigate their distribution and therapeutic effect.

SFRP4+ Stromal Cell Subpopulation with IGF1 Signaling in Human Endometrial Regeneration

[Cell Discovery] Scientists identified an SFRP4+ stromal cell subpopulation that was highly enriched in the regenerative stage of the human endometria during the menstrual cycle.

Human Fetal Membrane-Mesenchymal Stromal Cells Generate Functional Spinal Motor Neurons In Vitro

[iScience] Scientists demonstrated that human fetal membrane-MSCs could give rise to spinal motor neurons, by the sequential exposure to specific factors that induced a neuralization, caudalization, and ventralization of undifferentiated cells.

Fructose Promotes More than Glucose the Adipocytic Differentiation of Pig Mesenchymal Stem Cells

[Journal of Food Biochemistry] The authors evaluated how glucose and fructose affected the adipose differentiation of pig newborn MSCs. MSCs displayed adipose morphology after 70 days of differentiation.

AFF4 Regulates Cellular Adipogenic Differentiation via Targeting Autophagy

[PLoS Genetics] Knockdown of AF4/FMR2 family member 4 (AFF4) in human MSCs and mouse 3T3-L1 preadipocytes inhibited cellular adipogenic differentiation.

3D In Vitro Cultures of Human Bone Marrow and Wharton’s Jelly Derived Mesenchymal Stromal Cells Show High Chondrogenic Potential

[Frontiers in Bioengineering and Biotechnology] Chondrogenic potentials of 3D high-density cultures of Bone Marrow and Wharton’s Jelly-derived MSCs was investigated by chondrogenesis- and cytokine-related gene expression over a 16-day culture period supplemented with human transforming growth factor.

Mesenchymal Stem Cell-Derived Exosomes as New Tools for Delivery of miRNAs in the Treatment of Cancer

[Frontiers in Bioengineering and Biotechnology] Investigators provide an overview of the characteristics and potentials of MSC as well as the use of MSC-derived exosomes in cancer therapy.

$1M MRFF Grant Awarded to Fund Investigation of Cynata’s MSCs as a Treatment for Heart Disease

[Cynata Therapeutics Limited (BioSpace)] Cynata Therapeutics Limited announced that the Australian Government National Health and Medical Research Council has awarded a grant of approximately $1 million under the NHMRC 2021 MRFF Cardiovascular Health Mission, to fund a major preclinical research project to investigate Cynata’s Cymerus™ MSCs as a treatment for ischaemic heart disease.

Single-Cell Spatiotemporal Analysis Reveals Cell Fates and Functions of Transplanted Mesenchymal Stromal Cells during Bone Repair

[Stem Cell Reports] The authors developed a single-cell 3D spatial correlation (sc3DSC) method to track transplanted MSCs based on deep tissue microscopy of fluorescent nanoparticles (fNPs) and immunofluorescence of key proteins.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.

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