Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Mesenchymal Stromal Cells Protect Tissues from Th1 Immune Responses via IL-11 Secretion

[FASEB Journal] In vitro culture assays demonstrated that MSCs suppressed the activation and function of CD4+ T cells by secreting interleukin 11, and neutralization of IL11 abrogated MSC-mediated suppression of CD4+ T cell function.

HMGA1 Regulates Trabectedin Sensitivity in Advanced Soft-Tissue Sarcoma (STS): A Spanish Group for Research on Sarcomas (GEIS) Study

[Cellular and Molecular Life Sciences] The prognostic/predictive value of HMGA1 expression was assessed in a cohort of 301 STS patients at mRNA and protein level, by HTG EdgeSeq transcriptomics and immunohistochemistry, respectively.

Lineage-Specific Mesenchymal Stromal Cells Derived from Human iPSCs Showed Distinct Patterns in Transcriptomic Profile and Extracellular Vesicle Production

[Advanced Science] A stepwise human induced pluripotent stem cells-to-MSCs differentiation method was employed via intermediate cell stages of neural crest and cytotrophoblast to generate lineage-specific MSCs with varying differentiation efficiencies and gene expression.

HER3 (ERBB3) Amplification in Liposarcoma – a Putative New Therapeutic Target?

[World Journal of Surgical Oncology] Researchers performed fluorescence in situ hybridization analysis in 56 archived cases and subsequently performed reclassification to confirm the diagnosis of liposarcoma.

Lysyl Oxidase Production by Murine C3H10T1/2 Mesenchymal Stem Cells Is Increased by TGFβs and Differentially Modulated by Mechanical Stimuli

[Stem Cells And Development] The authors investigated how multiple factors previously identified to promote tendon formation and healing regulated lysyl oxidase production in the murine C3H10T1/2 MSC line.

Unveiling Heterogeneity in MSCs: Exploring Marker-Based Strategies for Defining MSC Subpopulations

[Journal of Translational Medicine] Scientists discuss the reported markers of MSCs, encompassing those developed through candidate marker strategies and high-throughput approaches.

Dr. Elizabeth Loggers Recognized as National Palliative Care Leader

[Fred Hutch Cancer Center] Dr. Elizabeth Loggers, medical director for the Supportive and Palliative Care Service at Fred Hutch Cancer Center, was recognized as an Emerging Leader in Hospice and Palliative Medicine by the American Academy of Hospice and Palliative Medicine.

Enhanced Anti-Tumor Efficacy with Multi-transgene Armed Mesenchymal Stem Cells for Treating Peritoneal Carcinomatosis

[Journal of Translational Medicine] The authors evaluated the feasibility of intraperitoneal administration of non-virally engineered MSCs to co-deliver cytosine deaminase and uracil phosphoribosyl transferase/5-Flucytosine prodrug system and interferon-beta to potentially enhance the cGAS-STING signaling axis.

Wogonin Preconditioning of MSCs Improved Their Therapeutic Efficiency for Colitis through Promoting Glycolysis

[Inflammopharmacology] Investigators employed the DSS-induced acute colitis mouse model to compare the therapeutic effectiveness of MSCs in pretreated with or without wogonin and further explore the underlying mechanism.

Carbon Monoxide-induced Autophagy Enhances Human Mesenchymal Stromal Cell Function via Paracrine Actions in Murine Polymicrobial Sepsis

[Molecular Therapy] Scientists evaluated carbon monoxide (CO)-induced autophagy in human(h) MSCs, and its impact on cell function in murine cecal ligation and puncture.

Linc-ADAIN, a Human Adipose lincRNA, Regulates Adipogenesis by Modulating KLF5 and IL-8 mRNA Stability

[Cell Reports] Researchers described the functions of linc-adipose anti-inflammatory (ADAIN), an adipose lincRNA that was downregulated in white adipose tissue of obese humans.

Navigating the Tumor Microenvironment: Mesenchymal Stem Cell-Mediated Delivery of Anticancer Agents

[Journal Of Drug Targeting] The authors elaborates on recent advancements of mesenchyma stem cell mediated drug delivery of anti-cancer agents along with its mechanism and previously reported studies of drugs manufactured via this drug delivery system.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.