Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Ohwia caudata Aqueous Extract Attenuates Senescence in Aging Adipose-Derived Mesenchymal Stem Cells

[Heliyon] Using 0.1 μM doxorubicin, investigators induced aging in human adipose-derived MSCs and evaluated whether various concentrations of O. caudata aqueous extract exhibited anti-aging effects on them.

Inhibition of the Galactosyltransferase C1GALT1 Reduces Osteosarcoma Cell Proliferation by Interfering with Erk Signaling and Cell Cycle Progression

[Cancer Gene Therapy] Researchers screened for differentially expressed genes in osteosarcoma. They found that osteosarcoma cases could be divided into fair and poor survival groups based on gene expression profiles.

POLE2 Promotes Osteosarcoma Progression by Enhancing the Stability of CD44

[Cell Death Discovery] GSE14359 chip from the GEO database was used to screen differentially expressed genes in osteosarcoma (OS). DNA polymerase epsilon 2 (POLE2) was confirmed to overexpress in OS tissues and cell lines by immunohistochemical staining, qPCR, and Western blot.

Effect of In Vivo Culture Conditions on the Proliferation and Differentiation of Rat Adipose-Derived Stromal Cells

[Mechanisms of Ageing and Development] Scientists transplanted separated adipose-derived stromal cells into local subcutaneous adipose tissues of nude mice as an in vivo cell culture model.

Modulating the Mesenchymal Stromal Cell Microenvironment Alters Exosome RNA Content and Ligament Healing Capacity

[Stem Cells] The authors used an in vitro system to compare the priming of human MSCs by two inflammatory inducers TNF-α and CRX-527 on exosome molecular cargo, as well as on an in vivo rat ligament injury model to validate exosome potency.

Tailored Apoptotic Vesicles Promote Bone Regeneration by Releasing the Osteoinductive Brake

[International Journal of Oral Science] Researchers compared MSCs, MSC derived apoptotic vesicles (MSC-apoVs), and MSC-exosomes from two types of MSC. They generated a map of miRNAs specific to MSC-apoVs and identified seven miRNAs specifically enriched in MSC-apoVs compared to MSCs and MSC-exosomes.

The Dual Role of Mesenchymal Stem Cells in Apoptosis Regulation

[Cell Death & Disease] The authors summarize the current evidence on the regulation of apoptosis by MSCs.

NIH Awards UAMS Researchers $2.27 Million to Study Estrogen’s Role in Preventing Bone Loss

[University of Arkansas for Medical Sciences] Researchers at the University of Arkansas for Medical Sciences (UAMS) will use a $2.27 million grant from the NIH to answer key questions about the cellular mechanisms used by estrogen to prevent bone loss and osteoporosis.

ALPL Regulates Pro-Angiogenic Capacity of Mesenchymal Stem Cells through ATP-P2X7 Axis Controlled Exosomes Secretion

[Journal of Nanobiotechnology] Exosomes derived from normal and hypophosphatasia human bone marrow MSCs were isolated and identified by ultracentrifugation, transmission electron microscopy, and nanoparticle size measurement.

HWJMSC-EVs Promote Cartilage Regeneration and Repair via the ITGB1/TGF-β/Smad2/3 Axis Mediated by Microfractures

[Journal of Nanobiotechnology] Researchers verify whether MSC-derived extracellular vesicles (MSC-EVs) promoted cartilage damage repair mediated by microfractures and to explore the repair mechanisms.

Bioengineered MSCCxcr2 Transdifferentiated Keratinocyte-Like Cell-Derived Organoid Potentiates Skin Regeneration Through ERK1/2 and STAT3 Signaling in Diabetic Wound

[Cellular And Molecular Life Sciences] 3D skin organoids generated using MSCCxcr2-derived keratinocyte-like cells upon grafting in a relatively avascular and non-healing wounds of type 2 diabetic transgenic mice resulted in a significant enhancement in the rate of wound closure by increased epithelialization and endothelialization.

Mitochondrial Ca2+ Signaling Is a Hallmark of Specific Adipose Tissue-Cancer Crosstalk

[Scientific Reports] The authors showed that conditioned media derived from adipose tissue cultures enriched in precursor cells impinge on mitochondrial Ca2+ homeostasis of target cells.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.