Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
FoxA1 Knockdown Promotes BMSC Osteogenesis in Part by Activating the ERK1/2 Signaling Pathway and Preventing Ovariectomy-Induced Bone Loss
[Scientific Reports] Researchers utilized a random walk-based method to evaluate genes associated with the process of osteogenic differentiation in human bone marrow-derived MSCs (hBMSCs). Lentiviral transfection was utilized to suppress the expression of the FOXA1 gene in hBMSCs.
Identification of Increased Dedifferentiation Along the Prom1+ Cancer Cells in Müllerian Adenosarcoma with Sarcomatous Overgrowth
[British Journal of Cancer] Scientists demonstrated that malignant stromal cells originated from fibrous tissue, Prom1-derived with complex intra-tumoral heterogeneity.
A Functionalized 3D-Printed Ti6Al4V “Cell Climbing Frame” Inspired by Marine Sponges to Recruit and Rejuvenate Autologous BMSCs in Osteoporotic Bone Repair
[Advanced Materials] Scientists developed a functionalized 3D-printed Ti6Al4V “Cell Climbing Frame”, aiming to adapt to the mechanical microenvironment of osteoporosis, recruit and support the adhesion and growth of autologous bone marrow MSCs, while rejuvenating senescent cells.
Deng Receives National Science Foundation Award to Research Bone Tissue Engineering
[Boise State News] Dr. Zhangxian Deng is a recipient of the National Science Foundation’s Faculty Early Career Development Award. Dr. Deng is spearheading efforts to engineer magnetically responsive biomaterials, enabling patient-specific bone tissue growth using MSCs harvested from patients.
Proteomic Profiling of iPSC and Tissue-Derived MSC Secretomes Reveal a Global Signature of Inflammatory Licensing
[NPJ Regenerative Medicine] The authors analyzed the secretomes of bone-marrow, umbilical-cord, adipose-tissue, and clinical/commercial-grade induced pluripotent stem cell-derived MSCs under resting and inflammatory licenced conditions.
3D Mechanical Response Stem Cell Complex Repairs Spinal Cord Injury by Promoting Neurogenesis and Regulating Tissue Homeostasis
[Advanced Healthcare Materials] Scientists created mechanical response stem cell complex as an innovative therapeutic strategy for spinal cord injury, utilizing 3D bioprinting technology and gelatin microcarriers loaded with MSCs.
Signaling Pathway Mechanisms of Circadian Clock Gene Bmal1 Regulating Bone and Cartilage Metabolism: A Review
[Bone Research] The authors review the signaling pathways by which brain and muscle arnt-like 1 (Bmal1) regulate bone/cartilage metabolism, the upstream regulatory factors that control Bmal1, and the current Bmal1 knockout mouse models for research.
āshibio Doses First Patient in ANDECAL Study, a Phase II/III Trial of Andecaliximab for Treatment of Fibrodysplasia Ossificans Progressiva (FOP)
[āshibio] āshibio announced the dosing of the first participant in its ANDECAL study, a Phase II/III clinical trial evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of andecaliximab in patients with FOP.
Mesenchymal Stromal Cell Exosomes for Drug Delivery of Prostate Cancer Treatments: A Review
[Stem Cell Research & Therapy] Owing to their unique biological characteristics, mesenchymal stromal cell exosomes have garnered significant attention for their potential to deliver targeted drugs and enable precise prostate cancer treatment.
Fusion of Tumor Cells and Mesenchymal Stem/Stroma Cells: A Source of Tumor Heterogeneity, Evolution, and Recurrence
[Medical Oncology] The authors examine the connection between MSC-tumor cell fusion and several critical factors like tumor heterogeneity, cancer stem cells, and therapy resistance, highlighting the crucial role of cell fusion in tumor survival, evolution, and recurrence.
Patient Enrollment Completed for EFTISARC-NEO Phase II Trial
[Immutep] Immutep announced that patient enrollment has been completed in the investigator-initiated EFTISARC-NEO trial. EFTISARC-NEO is evaluating eftilagimod alpha in combination with radiotherapy plus pembrolizumab in the neoadjuvant setting for patients with resectable soft tissue sarcoma.
Programmed Shape Transformations in Cell-Laden Granular Composites
[Science Advances] The authors used combinations of mesenchymal stromal cell spheroids and hydrogel microparticles with varied hydrolytic stability to fabricate programmable and dynamic granular composites that controlled compaction and tissue formation over time.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.