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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Gingival Mesenchymal Stem Cells: A Periodontal Regenerative Substitute
[Tissue Engineering and Regenerative Medicine] The authors comprehensively compiled and described several reports on GMSCs till date, including their basic properties and isolation protocols, subpopulations, spheroid gingival MSCs, and more.
Mesenchymal Stem/Stromal Cells: Dedicator to Maintain Tumor Homeostasis
[Human Cell] Scientists investigate the supportive role of MSCs in tumor cells as well as in various cellular and non-cellular components of the tumor microenvironment.
In Situ Licensing of Mesenchymal Stem Cell Immunomodulatory Function via BMP-2 Induced Developmental Process
[Proceedings of The National Academy of Sciences of The United States of America] Researchers combined the biological effects of materials with the osteogenic induction capabilities of bone morphogenetic protein (BMP)-2 to develop a unique method for in situ licensing of MSCs’ immunomodulatory function within a controlled inflammatory microenvironment constructed in vivo.
Adipose Tissue Retains an Epigenetic Memory of Obesity after Weight Loss
[Nature] By using single-nucleus RNA sequencing, the authors showed that both human and mouse adipose tissues retained cellular transcriptional changes after appreciable weight loss.
Single-Cell RNA Sequencing to Guide Autologous Preterm Cord Mesenchymal Stromal Cell-Therapy
[American Journal of Respiratory and Critical Care Medicine] scRNA-seq was used to compare the transcriptome of umbilical cord-derived MSCs derived from five term donors, 16 preterm donors, and human neonatal dermal fibroblasts, and correlated with their therapeutic potential in experimental bronchopulmonary dysplasia.
Macrophage Depletion in Inflamed Rat Knees Prevents the Activation of Synovial Mesenchymal Stem Cells by Weakening Nampt and Spp1 Signaling
[Inflammation and Regeneration] Acute inflammation was induced in rat knee joints by injection of carrageenan. Clodronate liposomes were administered intra-articularly on days 1 and 4 to deplete macrophages, with empty liposomes as a control.
Adipose Stem Cell Exosomes, Stimulated by Pro-Inflammatory Factors, Enhance Immune Evasion in Triple-Negative Breast Cancer by Modulating the HDAC6/STAT3/PD-L1 Pathway Through the Transporter UCHL1
[Cancer Cell International] The gene expression profiles of triple-negative breast cancer samples were downloaded from the TCGA database, and ubiquitination enzymes related to immune regulation were screened.
Classification of Pediatric Soft and Bone Sarcomas Using DNA Methylation-Based Profiling
[BMC Cancer] DNA methylation-based tumor profiling classifier for sarcomas from the German Cancer Research Center was applied to 122 pediatric sarcomas referred to a reference pediatric oncology hospital.
Mesenchymal Stromal Cell Therapies for Traumatic Neurological Injuries
[Journal of Translational Medicine] The authors review the literature and ongoing registered trials on the application of MSC for the treatment of traumatic brain injury, traumatic spinal cord injury, and peripheral nerve injury.
Ivar Mjör Award Awarded to Professor Igor Blum
[British Dental Journal] Professor Igor Blum of King's College London has been awarded the prestigious international Ivar Mjör Award for Practice-Based Research from the Network for Practice-Based Research at the International Association for Dental, Oral, and Craniofacial Research.
WAC Facilitates Mitophagy-mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination-Dependent Degradation
[Advanced Science] Scientists revealed that the levels of WW domain-containing coiled-coil adaptor (WAC) were diminished in both osteoporosis patients and osteoporosis mouse models. It played a pivotal function in facilitating MSC osteogenesis and enhancing new bone formation both in vitro and in vivo.
Renal Remodeling by CXCL10-CXCR3 Axis-Recruited Mesenchymal Stem Cells and Subsequent IL4I1 Secretion in Lupus Nephritis
[Signal Transduction and Targeted Therapy] Scientists elucidated that the migration of human umbilical cord-MSCs to the lupus nephritis kidney was driven by elevated levels of CXCL10, predominantly produced by glomerular vascular endothelial cells through the IFN-γ/IRF1-KPNA4 pathway.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
