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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Mesenchymal Stem Cell-Mediated Mitochondrial Transfer Regulates the Fate of B Lymphocytes
[European Journal of Clinical Investigation] The authors investigated signals that trigger mitochondrial transfer from MSCs to immune cells and evaluated its impact on the phenotype of recipient cells, with particular emphasis on B cells.
FDA Provides Seven Years of Orphan-Drug Exclusive Approval for Ryoncil®
[Mesoblast (BioSpace)] Mesoblast announced that it has received seven years of orphan-drug exclusive approval from US FDA for Ryoncil® for treatment of steroid-refractory acute graft versus host disease in pediatric patients 2 months of age and older.
Dynamic Profiling of BMSC-dECM Reveals Accumulation of Core Matrisome Proteins Suppresses Osteogenic Differentiation and Bone Regeneration
[Journal of Advanced Research] Scientists investigated the dynamic composition, functional properties, and underlying mechanisms of the extracellular matrix of bone MSC cells during osteogenic differentiation.
Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells (iMSCs) Inhibit M1 Macrophage Polarization and Reduce Alveolar Bone Loss Associated with Periodontitis
[Stem Cell Research & Therapy] The authors investigated the effects and mechanisms of ipsc-derived MSCs in modulating macrophage polarization and alleviating periodontitis-related alveolar bone loss.
Immunomodulatory Interactions between Mesenchymal Stromal/Stem Cells and Immune Cells in Psoriasis: Therapeutic Potential and Challenges
[Current Stem Cell Research & Therapy] Researchers investigate how MSCs interact with immune system cells involved in psoriasis development, such as neutrophils, keratinocytes, dendritic cells, and T cell subtypes, for potential therapeutic use in psoriasis management.
Emerging Technologies to Enhance Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells: Focus on Nanomaterials and Bioactive Compounds
[ACS Biomaterials Science & Engineering] Utilizing cutting-edge technologies, nanomaterials, and bioactive compounds can emulate the natural bone tissue microenvironment, and offer a three-dimensional scaffold that facilitates the osteogenic differentiation of BMSCs.
Optimizing Mesenchymal Stem Cell Therapy: From Isolation to GMP-Compliant Expansion for Clinical Application
[BMC Molecular and Cell Biology] Researchers demonstrated that infrapatellar fat pad MSCs exhibited enhanced proliferation rates when cultured in MSC-Brew GMP Medium compared to standard MSC media.
Cell Therapy with Placenta-Derived Mesenchymal Stem Cells for Secondary Progressive Multiple Sclerosis Patients in a Phase I Clinical Trial
[Scientific Reports] Investigators evaluated the safety and feasibility of placenta-derived MSCs in five participants with secondary-progressive multiple sclerosis.
Immunomodulatory Multifunctional Janus Collagen-Based Membrane for Advanced Bone Regeneration
[Nature Communications] Researchers presented a Janus collagen-based barrier membrane with immunomodulation. The membrane enhances rat bone marrow-derived MSC infiltration, proliferation, and osteogenic differentiation by regulating the immune microenvironment.
Biosplice Announces First Patient Dosed in Phase II Trial of Cirtuvivint for Advanced Soft-Tissue Sarcomas
[Biosplice (GlobeNewswire)] Biosplice Therapeutics, Inc. (“Biosplice”) announced that the first patient has been dosed in a Phase II clinical trial evaluating cirtuvivint in patients with advanced soft-tissue sarcomas.
Single-Cell Transcriptome Unveils Mesenchymal Cell Diversity in Endometriosis
[Human Molecular Genetics] Through the utilization of scRNA-seq, researchers have unveiled six distinct mesenchymal subclusters in normal and endometriosis-afflicted ovaries, elucidating the diverse functions of mesenchymal populations in endometriosis.
DNA Demethylating Agents Suppress Preclinical Models of Synovial Sarcoma
[Journal of Clinical Investigation] Given that synovial sarcoma is characterized by a peculiarly low DNA hypomethylation profile, researchers hypothesized that further disturbance of DNA methylation would have a negative impact on synovial sarcoma growth.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
