Kartogenin Prevents Cartilage Degradation and Alleviates Osteoarthritis Progression in Mice via the miR-146a/NRF2 Axis

Scientists explored the protective effects and underlying mechanisms of kartogenin on articular cartilage degradation using mice with post-traumatic osteoarthritis .
[Cell Death & Disease]
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Mesenchymal Stromal Cells Reduce Evidence of Lung Injury in Patients with ARDS

Scientists carried out a nested cohort study within a Phase IIa safety trial of treatment with allogeneic MSCs for moderate to severe ARDS.
[JCI Insight]
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Mesenchymal Stromal Exosome–Functionalized Scaffolds Induce Innate and Adaptive Immunomodulatory Responses toward Tissue Repair

Biofunctional scaffolds were prepared by immobilizing mesenchymal stromal exosomes onto fibrous polyester materials and allowed cell-mediated delivery of membrane-bound vesicles.
[Science Advances]
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Noxopharm’s Veyonda to Begin First-Line Sarcoma Treatment Testing

Noxopharm Limited announced its CEP-2 study will begin shortly. CEP-2 is related to the Investigational New Drug approval of Veyonda® by the FDA based on evidence that Veyonda may increase generally poor response rates of sarcoma cancers to chemotherapy in combination with common chemotherapy drug, doxorubicin, for patients with soft tissue sarcomas.
[Noxopharm Limited]
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Human Adipose Tissue-Derived Mesenchymal Stem Cells and Their Extracellular Vesicles Modulate Lipopolysaccharide Activated Human Microglia

Scientists determined the therapeutic potential of different human adipose tissue-derived-MSCs doses or their secreted extracellular vesicles, on human microglial cells that were activated by lipopolysaccharides
[Cell Death Discovery]
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Off-the-Shelf Bone Marrow-Derived Mesenchymal Stem Cell Treatment for Acute Graft-Versus-Host Disease: Real-World Evidence

Initial experience with Temcell, a cryopreserved, human bone marrow-derived MSC product, in a real-world setting from a cellular therapy registry in Japan is presented.
[Bone Marrow Transplantation]
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Integrated OMICs Unveil the Bone-Marrow Microenvironment in Human Leukemia

Researchers used multi-omics and computational tools to analyze multiple bone marrow environmental compartments and deciphered their mutual interactions in the context of acute myeloid leukemia xenografts.
[Cell Reports]
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Therapeutic Solutions International Subsidiary Campbell Neurosciences Reports Positive Preclinical Data in Animal Model of Schizophrenia Using Proprietary Universal Donor Mesenchymal Stem Cell

Therapeutic Solutions International, Inc. and its subsidiary Campbell Neurosciences announced new data covered by its previously filed patents supporting the use of mesenchymal based stem cell therapy for schizophrenia.
[Therapeutic Solutions International, Inc. (Cision US, Inc.)]
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Cryo-Cell International Proudly Announces Two Ongoing COVID-19 Related Trials

Cryo-Cell International, Inc. Medical Director, Dr. Joanne Kurtzberg and her research team at The Marcus Center for Cellular Cures at Duke University School of Medicine are currently conducting two major studies: MASC (Phase I/II) & MISTIC (Phase I) to treat, respectively, COVID-19 related Acute Respiratory Distress Syndrome and COVID-19 associated Multisystem Inflammatory Syndrome in Children.
[Cryo-Cell International, Inc.]
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Germinal GLT8D1, GATAD2A and SLC25A39 Mutations in a Patient with a Glomangiopericytal Tumor and Five Different Sarcomas over a 10-Year Period

The authors reported the unique case of a 72-year-old patient who presented with glomangiopericytal tumor followed by six sarcomas of the extremities between 2007 and 2016.
[Scientific Reports]
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In Vivo Cell Proliferation Analysis and Cell-Tracing Reveal the Global Cellular Dynamics of Periodontal Ligament Cells under Mechanical-Loading

Scientists investigated proliferating cells in mouse molar periodontal ligament during orthodontic tooth movement-induced tissue remodeling.
[Scientific Reports]
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