International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
Researchers developed a combined nano-cell therapy by using dendrimers complexed with plasmids targeting CCL20 and its sole receptor CCR6 to reduce inflammation followed by human mesenchymal stem cell transplantation.
[Nanomedicine-Nanotechnology Biology and Medicine]
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Mayilsamy, K., Markoutsa, E., Das, M., Chopade, P., Puro, D., Kumar, A., … Mohapatra, S. (2020). Treatment with shCCL20-CCR6 nanodendriplexes and human mesenchymal stem cell therapy improves pathology in mice with repeated traumatic brain injury. Nanomedicine: Nanotechnology, Biology and Medicine, 102247. https://doi.org/10.1016/j.nano.2020.102247 Cite
Scientists aimed to determine whether human bone marrow mesenchymal stem cells can differentiate into biliary epithelial cells in vitro and in vivo and to clarify the role of delta-like ligand 4 (DLL4) in restoring damaged liver by enhancing cholangiocyte differentiation.
[Stem Cell Research]
Investigators demonstrated 89Zr-oxine labeling and PET-CT imaging as a potential clinical solution for non-invasively tracking MSCTRAIL biodistribution
[Stem Cell Research & Therapy]
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Researchers utilised cell sorting and immunohistochemistry to identify a phenotypically-distinct, osteogenically-committed bone marrow stromal cell subset in human osteoarthritis trabecular bone.
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Ilas, D. C., Baboolal, T. G., Churchman, S. M., Jones, W. G., Giannoudis, P. V., Bühring, H.-J., … Jones, E. (2020). The osteogenic commitment of CD271+CD56+ bone marrow stromal cells (BMSCs) in osteoarthritic femoral head bone. Scientific Reports, 10(1), 11145. https://doi.org/10.1038/s41598-020-67998-0 Cite
Using transcriptional entropy as a metric for differentiated state, we found that the least differentiated Idiopathic Pulmonary Fibrosis mesenchymal progenitor cells (MPCs) displayed the largest differences in their transcriptional profile compared to control MPCs.
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Beisang, D. J., Smith, K., Yang, L., Benyumov, A., Gilbertsen, A., Herrera, J., … Bitterman, P. B. (2020). Single-cell RNA sequencing reveals that lung mesenchymal progenitor cells in IPF exhibit pathological features early in their differentiation trajectory. Scientific Reports, 10(1), 11162. https://doi.org/10.1038/s41598-020-66630-5 Cite
Scientists evaluated the antimicrobial activity and therapeutic effect of local treatment with antibiotic-loaded adipose-derived stem cells plus an antibiotic in a rat implant-associated infection model.
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Yoshitani, J., Kabata, T., Arakawa, H., Kato, Y., Nojima, T., Hayashi, K., … Tsuchiya, H. (2020). Combinational therapy with antibiotics and antibiotic-loaded adipose-derived stem cells reduce abscess formation in implant-related infection in rats. Scientific Reports, 10(1), 11182. https://doi.org/10.1038/s41598-020-68184-y Cite
A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
Since higher education institutions ended in-person classes in March due to the COVID-19 pandemic, there has been uncertainty over what classes will look like in the fall. Universities will soon have to come up with an answer.
Scientists proposed a new dual‐enzymatically cross‐linked and injectable gelatin hydrogel for regulating survival, proliferation and differentiation of human umbilical cord mesenchymal stem cells in three‐dimensional matrix.
[Journal of Tissue Engineering and Regenerative Medicine]
Researchers investigated the nephron-protective effect of human umbilical cord mesenchymal stem cells on renal fibrosis.
[European Journal of Pharmacology]
Investigators observed increased migration and reduced proliferation and differentiation when keratinocytes were co-cultured in media conditioned by human amniotic epithelial cell and human amniotic mesenchymal stem cells.