Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Platelet-Derived Apoptotic Vesicles Promote Bone Regeneration via Golgi Phosphoprotein 2 (GOLPH2)-AKT Signaling Axis

December 4, 2023

[ACS Nano] Investigators demonstrated that MSC-derived apoptotic vesicles (apoVs) were promising therapeutic agents for bone regeneration. However, clinical translation of MSC-derived apoVs had been hindered due to cell expansion and nuclear substance.

Enhancer-Mediated FOXO3 Expression Promotes MSC Adipogenic Differentiation by Activating Autophagy

December 4, 2023

[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] Researchers identified enhancers-mediated gene FOXO3 promoting MSC adipogenic differentiation by activating autophagy.

Amplification of poly(I:C)-Induced Interleukin-6 Production in Human Bronchial Epithelial Cells by Priming With Interferon-γ

November 30, 2023

[Scientific Reports] Researchers showed that pretreatment of human bronchial epithelial cells with interferon-γ markedly increased IL-6 production induced by the toll-like receptor 3 agonist poly(I:C) from 0.4 ± 0.1 to 4.1 ± 0.4 ng/mL.

Mesenchymal Stem Cell Conditioned Medium Alleviates Acute Lung Injury through KGF-Mediated Regulation of Epithelial Sodium Channels

November 28, 2023

[Biomedicine & Pharmacotherapy] Both lipopolysaccharides-induced mouse and alveolar organoid acute lung injury models were established to confirm the potential therapeutic effect of mesenchymal stem cells secreted keratinocyte growth factor (KGF).

The DNA/RNA Helicase DHX9 Orchestrates the KDM2B-Mediated Transcriptional Regulation of YAP1 in Ewing Sarcoma

November 28, 2023

[Oncogene] Transcriptome profiling combined to bioinformatic analyses disclosed a gene signature commonly regulated by DHX9 and the lysine demethylase KDM2B, with the Hippo pathway regulator YAP1 as a prominent target in Ewing sarcoma.

Tauroursodeoxycholic Acid Inhibited Apoptosis and Oxidative Stress in H2O2-Induced BMSC Death via Modulating the Nrf-2 Signaling Pathway: The Therapeutic Implications in a Rat Model...

November 28, 2023

[Molecular Neurobiology] Researchers studied the possible benefits of combining tauroursodeoxycholic acid with bone marrow MSC transplantation using an animal model of spinal cord injury.

Improvement of Inflammation and Abnormal Vascularization by TSP1 Treatment Combined with ADSCs Transplantation in Mice with Induced Polycystic Ovary Syndrome

November 28, 2023

[Advanced Biology] The authors investigated the efficacy of the combined use of adipose-derived mesenchymal stem cells (ADSCs) and thrombospondin 1 (TSP1) in polycystic ovary syndrome mice.

Developmental Potency of Human ES Cell-Derived Mesenchymal Stem Cells Revealed in Mouse Embryos Following Blastocyst Injection

November 27, 2023

[Cell Reports] Scientists injected GFP-tagged human ESC-derived MSCs (EMSCs) into mouse blastocysts. EMSCs survived well and penetrated both the inner cell mass and trophectoderm, correlating to the higher anti-apoptotic capability of EMSCs than hESCs.

The BRD4-SRPK2-SRSF2 Signal Modulates the Splicing Efficiency of ACSL3 Pre-mRNA and Influences Erastin-Induced Ferroptosis in Osteosarcoma Cells

November 27, 2023

[Cell Death & Disease] Mechanically, bromodomain-containing protein 4 (BRD4) controlled the splicing efficiency of the RNA precursor of acyl-CoA synthase 3 (ACSL3) by recruiting serinerich/threonine protein kinase 2 (SRPK2) to assemble the splicing catalytic platform.

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Provide Neuroprotection in Traumatic Brain Injury through the lncRNA TUBB6/Nrf2 Pathway

November 27, 2023

[Brain Research] Investigators found that administration of human umbilical cord MSC-exosome suppressed traumatic brain injury-induced inflammation and ferroptosis.

High Expression of ACKR1 Predicts a Good Prognosis and Suppresses Sarcoma Cell Progression via Regulating the Tumor Immune Microenvironment

November 27, 2023

[Journal of Applied Genetics] Scientists analyzed the functions of atypical chemokine receptor 1 (ACKR1) in sarcoma progression and its potential mechanism.

Induction of Mesenchymal Stem Cell (MSC) Differentiation from iPS Cells Using MSC Medium

November 27, 2023

[Dental Materials Journal] The authors investigated whether induced pluripotent stem cells could be differentiated into MSCs using MSCGM, a commercially available MSC culture system.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.