Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

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BioRestorative Therapies Reports Positive Phase II Blinded Data for BRTX-100 Demonstrating Meaningful Improvements in Pain and Function in Chronic Lumbar Disc Disease

March 31, 2026

[BioRestorative Therapies, Inc.] BioRestorative Therapies, Inc. announced blinded data from its Phase II clinical trial evaluating hypoxic-cultured MSCs for the treatment of chronic lumbar disc disease, with 50% or more of treated patients reporting improvements >50% across key pain and functional outcome measures and no adverse events related to dose-limiting toxicities.

Honoring the Hard Work of Doctors at Moffitt Cancer Center

March 31, 2026

[Moffitt Cancer Center] At Moffitt Cancer Center, there are countless doctors, researchers, and clinicians on the frontlines caring for patients every day.

BMSC-Derived Extracellular Vesicles Enhance Osteosarcoma Proliferation and Metastasis via the circRNA-0010220/β-Catenin Pathway

March 31, 2026

[Cell Death & Disease] Scientists identified a novel molecular axis centered on circRNA-0010220 within bone marrow MSC-derived extracellular vesicles that drives osteosarcoma aggressiveness.

Phenotypic Alterations and PI3K-AKT Pathway Regulation in Senescence of Human Tonsil Mesenchymal Stem Cells

March 31, 2026

[Stem Cell Research & Therapy] This study aimed to elucidated senescence-related phenotypic alterations and regulatory mechanisms in human tonsil-derived MSCs.

Engineering Cartilaginous Constructs by Integrating Umbilical Cord-Derived Mesenchymal Stem Cell Spheroids and Localized Mineral Ion Delivery in 3D Hydrogel

March 31, 2026

[Biofabrication] Investigators reported a 3D cartilaginous construct by encapsulation of spheroids of human umbilical cord–derived MSCs within gelatin methacryloyl hydrogels where the mineral–coated fibers were integrated within the spheroid for localized ion delivery, thereby alleviating diffusion limitations.

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

March 31, 2026

[Advanced Science] The authors review current advances in MSC-based therapies for immune-related disorders, emphasizing Phase III and IV clinical trials and therapies approved by global regulatory agencies.

Mesenchymal Stem Cells and Secretome As Modulators of Neuroinflammation in Neurological Disorders

March 31, 2026

[Journal of Translational Medicine] MSCs and their cell-free secretome represent a promising therapeutic platform for neurological disorders by directly targeting neuroinflammation. Future progress will depend on developing next-generation, potentially bioengineered, secretome-based products with defined potency to bring this regenerative strategy from the laboratory to the clinic.

14-3-3γ Knockdown Promotes Matrix Mineralization in Human Mesenchymal Stromal Cells

March 31, 2026

[Cell Death & Disease] Researchers investigated the function of 14-3-3γ in the osteogenic differentiation of human adipose-derived MSCs. Using an adenoviral system, they knocked down 14-3-3γ and assessed osteogenic markers.

Th17-Driven CD8+ T Cells in hUC-MSC and CAR T-Cell Dual Immunotherapy for Superior Anti-Tumor Efficacy

March 31, 2026

[Cell Death & Disease] Investigators reported the development of a novel dual cellular immunotherapy in which human umbilical cord-derived MSCs are co-administered with CD19 CAR T-cells.

Spatial Single Cell Transcriptomic Analysis Informs Tumor Developmental Hierarchy of DICER1 Syndrome Related Sarcoma

March 31, 2026

[Nature Communications] The authors established a lineage-traceable genetically engineered mouse model with controlled activation of hemizygous Dicer1 RNase IIIb mutation in Hic1+ mesenchymal stromal cells.

Gli2 and Gli3 Synergistically Mediate HH-TGF-β Crosstalk in Mesenchymal Progenitor Cells to Orchestrate Tooth Root Morphogenesis

March 16, 2026

[International Journal of Oral Science] Scientists revealed that loss of Gli3 alone in dental mesenchymal root progenitor cells caused shortened roots and that concurrent loss of Gli2 and Gli3 exacerbated root malformations, concomitant with profound impairments in cell proliferation and multilineage differentiation.

Microfluidic Encapsulation of Genetically Engineered Bone-Marrow-Derived Mesenchymal Stem Cells for Bone Defect Healing

March 16, 2026

[Advanced Healthcare Materials] Researchers transfected bone MSCs with RUNX2 plasmid nanoparticles and encapsulated them into gelatin methacryloyl hydrogel microcarriers for bone regeneration.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.