Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Enhanced Anti-Tumor Efficacy with Multi-transgene Armed Mesenchymal Stem Cells for Treating Peritoneal Carcinomatosis

[Journal of Translational Medicine] The authors evaluated the feasibility of intraperitoneal administration of non-virally engineered MSCs to co-deliver cytosine deaminase and uracil phosphoribosyl transferase/5-Flucytosine prodrug system and interferon-beta to potentially enhance the cGAS-STING signaling axis.

Wogonin Preconditioning of MSCs Improved Their Therapeutic Efficiency for Colitis through Promoting Glycolysis

[Inflammopharmacology] Investigators employed the DSS-induced acute colitis mouse model to compare the therapeutic effectiveness of MSCs in pretreated with or without wogonin and further explore the underlying mechanism.

Carbon Monoxide-induced Autophagy Enhances Human Mesenchymal Stromal Cell Function via Paracrine Actions in Murine Polymicrobial Sepsis

[Molecular Therapy] Scientists evaluated carbon monoxide (CO)-induced autophagy in human(h) MSCs, and its impact on cell function in murine cecal ligation and puncture.

Linc-ADAIN, a Human Adipose lincRNA, Regulates Adipogenesis by Modulating KLF5 and IL-8 mRNA Stability

[Cell Reports] Researchers described the functions of linc-adipose anti-inflammatory (ADAIN), an adipose lincRNA that was downregulated in white adipose tissue of obese humans.

Navigating the Tumor Microenvironment: Mesenchymal Stem Cell-Mediated Delivery of Anticancer Agents

[Journal Of Drug Targeting] The authors elaborates on recent advancements of mesenchyma stem cell mediated drug delivery of anti-cancer agents along with its mechanism and previously reported studies of drugs manufactured via this drug delivery system.

MSC Promotes the Secretion of Exosomal lncRNA KLF3-AS1 to Regulate Sphk1 through YY1-Musashi-1 Axis and Improve Cerebral Ischemia–Reperfusion Injury

[Molecular Neurobiology] The oxygen–glucose deprivation/reoxygenation and middle cerebral artery occlusion rat model were generated. MSCs were isolated and characterized by flow cytometry and histochemical staining, and MSC exosomes were purified and characterized by transmission electron microscopy, flow cytometry, and Western blot.

A Novel miR-466l-3p/FGF23 Axis Promotes Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells

[Bone] Scientists investigated the potential role of miR-466 l-3p in osteoporosis (OP). The expression levels of miR-466 l-3p and fibroblast growth factor 23 (FGF23) were quantified in the trabeculae of the femoral neck of 40 individuals with or without OP using qRT-PCR.

Vasoactive Intestinal Peptide Exerts an Osteoinductive Effect in Human Mesenchymal Stem Cells

[BioFactors] Researchers characterized the influence of the neuropeptide vasoactive intestinal peptide on the differentiation process of human MSCs into osteoblasts and on their anabolic function.

Synergistic Effect of Mesenchymal Stem Cell-Derived Extracellular Vesicle and miR-137 Alleviates Autism-Like Behaviors by Modulating the NF-κB Pathway

[Journal of Translational Medicine] The authors explored the effectiveness of MSC-derived extracellular vesicles loaded with miR-137 in enhancing autism-like behaviors and mitigating neuroinflammation.

Melatonin and Mesenchymal Stem Cells Co-Administration Alleviates Chronic Obstructive Pulmonary Disease via Modulation of Angiogenesis at the Vascular-Alveolar Unit

[Pflugers Archiv-European Journal Of Physiology] The COPD model was established using cigarette smoking and lipopolysaccharide. The COPD rats were divided into four groups: COPD group, Melatonin-treated group, MSC-treated group, and combined treated group, Melatonin–MSCs.

Mesenchymal Stem Cell Secretome for Regenerative Medicine: Where Do We Stand?

[Journal of Advanced Research] Investigators discuss the potential benefits of MSC-derived secretome in regenerative medicine with particular focus on respiratory, hepatic, and neurological diseases.

NSF Awards $630,000 to Study Teeth of Non-Human Primates

[University of Arkansas (EurekAlert)] The National Science Foundation (NSF) awarded $630,444 to Kathleen Paul, an assistant professor of anthropology at the University of Arkansas, to provide a comprehensive outline of dental genetic architecture for two primate species of tamarins and macaques.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.