Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

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Nobel Prizes Are Globally Unrepresentative — the Nomination Process Must Be Opened Up

October 10, 2024

The geography of science is changing. As a result, a big push is needed to broaden the pool of scientists eligible to nominate their...

Photoactivated Hydrogel Therapeutic System with MXene-Based Nanoarchitectonics Potentiates Endogenous Bone Repair Through Reshaping the Osteo-Vascularization Network

October 10, 2024

[Small] In vivo experiments revealed that the spatiotemporalized hydrogel platform synergized with mild photothermal treatment significantly accelerated critical-sized bone defect healing by increasing the osteo-vascularization network density, recruiting endogenous stem cells, and facilitating the production of osteogenesis/angiogenesis-related factors.

The Therapeutic Use of Dental Mesenchymal Stem Cells in Human Clinical Trials

October 10, 2024

[Journal of Dental Research] The authors provide a contemporary overview of the evolving landscape of stem cell therapy, offering insights into the latest developments and trends as well as the challenges that need to be addressed for the widespread application of dental MSC-based cell therapies.

miR-378a-3p Regulates the BMP2-Smad Pathway to Promote Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells

October 9, 2024

[Cell Biochemistry and Biophysics] Scientists elucidated the role of miR-378a-3p in facilitating the proliferation and differentiation of synovium-derived MSCs (SMSCs) into chondrocytes. The effects of overexpressing miR-378a-3p on SMSCs were investigated through histological analysis, quantitative PCR, and western blotting.

Mechanism Research of Elastic Fixation Promoting Fracture Healing Based on Proteomics and Fracture Microenvironment

October 9, 2024

[Bone & Joint Research] Elastic fixation could promote fracture healing and osteoblast differentiation in callus, and the ability of elastic fixation to promote osteogenic differentiation of BMSCs may be achieved by upregulating genes such as thrombospondin 1 and osteoglycin.

Shh Signaling from the Injured Lung Microenvironment Drives BMSCs Differentiation into Alveolar Type II Cells for Acute Lung Injury Treatment in Mice

October 9, 2024

[Stem Cells International] Promoting alveolar type II (AT2) cell regeneration through the differentiation of BMSCs into AT2 cells was one of the important therapeutic mechanisms for the treatment of acute lung injury with BMSCs.

Injectable Decellularized Wharton’s Jelly Hydrogel Containing CD56+ Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for Meniscus Tear Healing and Cartilage Protection

October 1, 2024

[Materials Today Bio] Modified decellularized Wharton's Jelly hydrogel (DWJH) was combined with isolated CD56+Exos from CD56+umbilical cord MSCs to fabricate DWJH/CD56+Exos. The in vitro studies were performed to characterize the DWJ.

Ultrasound-Generated Bubbles Enhance Osteogenic Differentiation of Mesenchymal Stromal Cells in Composite Collagen Hydrogels

October 1, 2024

[Bioactive Materials] Scientists developed a composite hydrogel, consisting of type I collagen and phase-shift emulsion, where osteogenic differentiation of MSCs can be non-invasively modulated using ultrasound.

Direct Conversion of Human Umbilical Cord Mesenchymal Stem Cells into Dopaminergic Neurons for Parkinson’s Disease Treatment

October 1, 2024

[Neurobiology of Disease] Investigators developed a one-step differentiation system using the YFBP cocktail (Y27632, Forskolin, SB431542, and SP600125) to effectively convert human umbilical cord MSCs into dopaminergic neurons without genetic modification.

Bone Marrow Mesenchymal Stem Cell and Mononuclear Cell Combination Therapy in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Study with 8-Year Follow-Up

October 1, 2024

[Stem Cell Research & Therapy] Investigators explored the long-term effects of combining bone marrow MSCs with mononuclear cells in the treatment of type 2 diabetes mellitus.

Mesenchymal Non-Meningothelial Tumors of the CNS: Evolving Molecular Landscape and Implications for Neuroradiologists

October 1, 2024

[American Journal of Neuroradiology] The authors provide a comprehensive overview of primary mesenchymal non-meningothelial central nervous system tumors, including their clinical, radiological, histopathological, and molecular characteristics and treatment strategies.

Identification of ENO-1 Positive Extracellular Vesicles as a Circulating Biomarker for Monitoring of Ewing Sarcoma

September 26, 2024

The authors described a sensitive analytical technique for tumor monitoring of Ewing sarcoma by detecting circulating extracellular vesicles secreted from Ewing sarcoma cells. Full Article

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.