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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Injectable Decellularized Wharton’s Jelly Hydrogel Containing CD56+ Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for Meniscus Tear Healing and Cartilage Protection
[Materials Today Bio] Modified decellularized Wharton's Jelly hydrogel (DWJH) was combined with isolated CD56+Exos from CD56+umbilical cord MSCs to fabricate DWJH/CD56+Exos. The in vitro studies were performed to characterize the DWJ.
Ultrasound-Generated Bubbles Enhance Osteogenic Differentiation of Mesenchymal Stromal Cells in Composite Collagen Hydrogels
[Bioactive Materials] Scientists developed a composite hydrogel, consisting of type I collagen and phase-shift emulsion, where osteogenic differentiation of MSCs can be non-invasively modulated using ultrasound.
Direct Conversion of Human Umbilical Cord Mesenchymal Stem Cells into Dopaminergic Neurons for Parkinson’s Disease Treatment
[Neurobiology of Disease] Investigators developed a one-step differentiation system using the YFBP cocktail (Y27632, Forskolin, SB431542, and SP600125) to effectively convert human umbilical cord MSCs into dopaminergic neurons without genetic modification.
Bone Marrow Mesenchymal Stem Cell and Mononuclear Cell Combination Therapy in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Study with 8-Year Follow-Up
[Stem Cell Research & Therapy] Investigators explored the long-term effects of combining bone marrow MSCs with mononuclear cells in the treatment of type 2 diabetes mellitus.
Mesenchymal Non-Meningothelial Tumors of the CNS: Evolving Molecular Landscape and Implications for Neuroradiologists
[American Journal of Neuroradiology] The authors provide a comprehensive overview of primary mesenchymal non-meningothelial central nervous system tumors, including their clinical, radiological, histopathological, and molecular characteristics and treatment strategies.
Identification of ENO-1 Positive Extracellular Vesicles as a Circulating Biomarker for Monitoring of Ewing Sarcoma
The authors described a sensitive analytical technique for tumor monitoring of Ewing sarcoma by detecting circulating extracellular vesicles secreted from Ewing sarcoma cells. Full Article
Senescent Lung-Resident Mesenchymal Stem Cells Drive Pulmonary Fibrogenesis through FGF-4/FOXM1 Axis
Lung fibrosis was induced using bleomycin in C57BL/6 mice. Cellular senescence was measured by immunofluorescence. Full Article
Mesenchymal Stem Cells in Tumor Microenvironment: Drivers of Bladder Cancer Progression through Mitochondrial Dynamics and Energy Production
Researchers analyzed 205 patient samples to explore the relationships between tumor-stroma ratio and clinicopathological features. Full ArticleGraphical Abstract
New Global Guidance Puts Forward Recommendations for More Effective and Equitable Clinical Trials
The World Health Organization (WHO) released guidance to improve the design, conduct and oversight of clinical trials in countries of all income levels. This...
Mesenchymal Stromal Cell Transplantation Ameliorates Fibrosis and microRNA Dysregulation in Skeletal Muscle Ischaemia
[Stem Cells] Scientists reported a human umbilical cord MSC-mediated amelioration of ischaemia-induced skeletal muscle atrophy and function via enhancement of myofibre regeneration, reduction of tissue inflammation, adipocyte accumulation, and tissue fibrosis.
Magnesium-Enhanced Porcine Particles Using Hydrothermal Technique Improve the Osteogenic Differentiation of Cells
[Rsc Advances] Scientists proved that the hydrothermal method could be used to coat magnesium oxide on the surface of a porcine graft and enhance the biomaterial's property for better osteogenic differentiation of osteoblasts in vitro.
Engineered Enucleated Mesenchymal Stem Cells Regulating Immune Microenvironment and Promoting Wound Healing
[Advanced Materials] Researchers engineered an enucleated mesenchymal stem cell by aptamer bioorthogonal chemistry to modify the cell membrane and mRNA loading in the cell cytoplasm as a novel delivery vector with accurate targeting and sustained cytokine secretion.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
