Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Mimicking Bone Extracellular Matrix: From BMP-2-Derived Sequences to Osteogenic-Multifunctional Coatings

[Advanced Healthcare Materials] The wrist and knuckle epitopes of BMP-2 are screened to identify peptides with potential osteogenic properties.

Rain Therapeutics Announces Completion of Enrollment in Phase III MANTRA Trial for Milademetan in Liposarcoma

[Rain Therapeutics, Inc.] Rain Therapeutics Inc. announced completion of enrollment in its Phase III MANTRA randomized, global, registrational trial of its lead product candidate, milademetan, an oral, small molecule inhibitor of the MDM2-p53 complex that reactivates p53.

TOP3A Amplification and ATRX Inactivation Are Mutually Exclusive Events in Pediatric Osteosarcomas Using ALT

[EMBO Molecular Medicine] Scientists reported that most high-grade pediatric osteosarcomas maintained their telomeres by alternative lengthening of telomeres (ALT), and that the majority of these ALT tumors were ATRX wild-type and instead carried an amplified 17p11.2 chromosomal region containing TOP3A.

Endogenous Follistatin-Like 1 Guarantees the Immunomodulatory Properties of Mesenchymal Stem Cells during Liver Fibrotic Therapy

[Stem Cell Research & Therapy] Investigators characterized the potential role of follistatin-like 1 in MSC-based anti-fibrotic therapy and further elucidated the mechanisms underlying its action.

Overexpressing HPGDS in Adipose-Derived Mesenchymal Stem Cells Reduces Inflammatory State and Improves Wound Healing in Type 2 Diabetic Mice

[Stem Cell Research & Therapy] Investigators engineered adipose-derived MSCs (ADSCs) to overexpress hematopoietic prostaglandin D synthase (ADSCHpgds) and evaluated its effects on diabetic wound healing using a full-thickness skin wound model.

Exosomal MicroRNA-551b-3p from Bone Marrow-Derived Mesenchymal Stromal Cells Inhibits Breast Cancer Progression via Regulating TRIM31/Akt Signaling

[Human Cell] Researchers found that upregulation of miR-551b-5p suppressed the proliferation and migration and induced the apoptosis of breast cancer cells via downregulating tripartite motif-containing protein 31 (TRIM31).

Umbilical Cord Mesenchymal Stem Cells and Breast Cancer: A Good Therapeutic Candidate or Not? A Minireview

[Molecular Biology Reports] The authors review the influences of umbilical cord-derived MSCs on breast cancer and summarize this with a focus on the molecular mechanisms involved in its pathogenesis and treatment.

Stem Cell-Based Therapy for Human Diseases

[Signal Transduction and Targeted Therapy] Scientists provide an update on recent clinical applications using either human pluripotent stem cells or mesenchymal stem cells derived from bone marrow, adipose tissue, or the umbilical cord for the treatment of human diseases.

Extracellular Vesicles Derived from Wharton’s Jelly Mesenchymal Stem Cells Inhibit the Tumor Environment via the miR-125b/HIF1α Signaling Pathway

[Scientific Reports] The authors suggested a novel strategy to treat triple negative breast cancer (TNBC) using mesenchymal stem cell-derived extracellular vesicles to transform the behaviors and cellular communication of TNBC cells with other non-cancer cells related to tumorigenesis and metastasis.

Human Umbilical Cord Mesenchymal Stem Cells for Psoriasis: A Phase I/IIa, Single-Arm Study

[Signal Transduction and Targeted Therapy] Investigators performed a Phase I/IIa, single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs in the treatment of psoriasis and preliminarily explored the possible mechanisms.

Exocrine Pancreas Regeneration Modifies Original Pancreas to Alleviate Diabetes in Mouse Models

[Science Translational Medicine] The authors showed that pancreas-derived mesenchymal stem cells were capable of regenerating exocrine pancreas when implanted into the kidney capsule of mice with streptozotocin–induced diabetes.

Mesenchymal Tumor Organoid Models Recapitulate Rhabdomyosarcoma Subtypes

[EMBO Molecular Medicine] Investigators described the generation of a collection of 19 pediatric rhabdomyosarcomas tumor organoid models comprising all major subtypes.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.