Extracellular Vesicle-Derived microRNA-18b Ameliorates Preeclampsia by Enhancing Trophoblast Proliferation and Migration via Notch2/TIM3/mTORC1 Axis

Researchers studied the underlying mechanism of extracellular vesicle‐derived microRNA‐18 in preeclampsia.
[Journal of Cellular and Molecular Medicine]
Yang, Z., Shan, N., Deng, Q., Wang, Y., Hou, Y., Mei, J., & Wu, Z. (n.d.). Extracellular vesicle-derived microRNA-18b ameliorates preeclampsia by enhancing trophoblast proliferation and migration via Notch2/TIM3/mTORC1 axis. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16234 Cite
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Dodging COVID-19 Infection: Low Expression and Localization of ACE2 and TMPRSS2 in Multiple Donor-Derived Lines of Human Umbilical Cord-Derived Mesenchymal Stem Cells

Expression of Angiotensin-Converting Enzyme 2 (ACE2) and TMPRSS2 was analyzed in 24 lots of human umbilical cord-MSCs derived from Wharton’s jelly via quantitative PCR, Western Blot, immunofluorescence and flow cytometry using 24 different donors.
[Journal of Translational Medicine]
Hernandez, J. J., Beaty, D. E., Fruhwirth, L. L., Lopes Chaves, A. P., & Riordan, N. H. (2021). Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells. Journal of Translational Medicine, 19(1), 149. https://doi.org/10.1186/s12967-021-02813-6 Cite
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Extracellular Matrix Scaffolds Derived from Different Musculoskeletal Tissues Drive Distinct Macrophage Phenotypes and Direct Tissue-Specific Cellular Differentiation

Researchers demonstrated that macrophages adopt distinct phenotypes when exposed to articular cartilage, ligament and growth plate derived extracellular matrix scaffolds.
[Journal of Immunology and Regenerative Medicine]
Mahon, O. R., Browe, D. C., Diaz-Payno, P. J., Pitacco, P., Cunningham, K. T., Mills, K. H. G., Dunne, A., & Kelly, D. J. (2021). Extracellular matrix scaffolds derived from different musculoskeletal tissues drive distinct macrophage phenotypes and direct tissue-specific cellular differentiation. Journal of Immunology and Regenerative Medicine, 100041. https://doi.org/10.1016/j.regen.2021.100041 Cite
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3D Cell Sheet Structure Augments Mesenchymal Stem Cell Cytokine Production

MSCs cultivated on temperature-responsive culture dishes to a confluent 2D monolayer were harvested by temperature reduction from 37 to 20°C that induced a surface wettability transition from hydrophobic to hydrophilic.
[Scientific Reports]
Bou-Ghannam, S., Kim, K., Grainger, D. W., & Okano, T. (2021). 3D cell sheet structure augments mesenchymal stem cell cytokine production. Scientific Reports, 11(1), 8170. https://doi.org/10.1038/s41598-021-87571-7 Cite
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Mesenchymal Stem/Stromal Cell-Based Therapy: Mechanism, Systemic Safety and Biodistribution for Precision Clinical Applications

Researchers summarize the current state of MSC-based cell therapy, focusing on the systemic safety and biodistribution of MSCs.
[Journal of Biomedical Science]
Zhuang, W.-Z., Lin, Y.-H., Su, L.-J., Wu, M.-S., Jeng, H.-Y., Chang, H.-C., Huang, Y.-H., & Ling, T.-Y. (2021). Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications. Journal of Biomedical Science, 28(1), 28. https://doi.org/10.1186/s12929-021-00725-7 Cite
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Researchers Receive Grant to Improve Cellular Therapies to Treat ‘Incurable’ Diseases

Two University of Arkansas researchers received a $480,000 National Science Foundation grant to investigate how engineered coatings that imitate the tissue matrix surrounding cells would affect the behavior of therapeutic human mesenchymal stromal cells, or hMSCs.
[University of Arkansas]
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Therapeutic Solutions International with Subsidiary Campbell Neurosciences Develops Cord Blood Based Inhalable Product for Opioid Addiction

Therapeutic Solutions International, Inc., announced filing of a patent with new data covering a cord blood based intranasal product demonstrated to reduce adverse mental effects associated with opioid addiction.
[Therapeutic Solutions International, Inc. (PR Newswire)]
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A Single Cell Atlas of Human Teeth

Researchers mapped the transcriptional landscape of the various cell populations that compose human teeth at single-cell resolution, and analyzed in deeper detail their stem cell populations and their microenvironment.
[iScience]
Pagella, P., Roditi, L. de V., Stadlinger, B., Moor, A. E., & Mitsiadis, T. A. (2021). A single cell atlas of human teeth. IScience, 0(0). https://doi.org/10.1016/j.isci.2021.102405 Cite
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Sentien Biotechnologies Completes Enrollment of First Cohort in Phase I/II Trial of Ex Vivo MSC Therapy for the Treatment of Severe COVID-19

Sentien Biotechnologies, Inc. announced it has completed enrollment of the first cohort in its Phase I/II study of SBI-101 for the treatment of severe COVID-19. SBI-101is being evaluated in COVID-19 patients suffering from both acute respiratory distress syndrome and acute kidney injur requiring renal replacement therapy.
[Sentien Biotechnologies, Inc.]
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Novel BRAF Gene Fusions and Activating Point Mutations in Spindle Cell Sarcomas with Histologic Overlap with Infantile Fibrosarcoma

Investigators report the clinicopathologic and molecular features of 14 BRAF-altered tumors, of which five had BRAF point mutations and ten harbored one or more BRAF fusions.
[Modern Pathology]
Penning, A. J., Al-Ibraheemi, A., Michal, M., Larsen, B. T., Cho, S.-J., Lockwood, C. M., Paulson, V. A., Liu, Y. J., Plank, L., Fritchie, K., Beadling, C., Neff, T. L., Corless, C. L., Rudzinski, E. R., & Davis, J. L. (2021). Novel BRAF gene fusions and activating point mutations in spindle cell sarcomas with histologic overlap with infantile fibrosarcoma. Modern Pathology, 1–11. https://doi.org/10.1038/s41379-021-00806-w Cite
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Mesenchymal Stem Cells Accelerated Growth and Metastasis of Neuroblastoma and Preferentially Homed towards Both Primary and Metastatic Loci in Orthotopic Neuroblastoma Model

Human MSCs mixed with neuroblastoma cells significantly accelerated tumor growth and apparently enhanced metastasis of neuroblastoma in vivo.
[BMC Cancer]
Yu, J.-L., Chan, S., Fung, M. K.-L., & Chan, G. C.-F. (2021). Mesenchymal stem cells accelerated growth and metastasis of neuroblastoma and preferentially homed towards both primary and metastatic loci in orthotopic neuroblastoma model. BMC Cancer, 21(1), 393. https://doi.org/10.1186/s12885-021-08090-2 Cite
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