Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

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Investigation of the Osteogenic Effects of ICA and ICSII on Rat Bone Marrow Mesenchymal Stem Cells

January 24, 2025

[Scientific Reports] Researchers compared the osteogenic effects of Icariin (ICA) and Icariside II (ICSII), along with their respective osteogenic mechanisms.

Long Noncoding RNA DHRS4 Antisense RNA 1 Suppresses Osteosarcoma Cell Proliferation and Promotes Apoptosis through a Competitive Endogenous RNA Mechanism

January 23, 2025

[Scientific Reports] DHRS4 antisense RNA 1 (DHRS4-AS1) expression was detected in osteosarcoma (OS) cells by quantitative PCR. Gain- and loss-of-function experiments were conducted to study the effects of DHRS4-AS1 on the proliferation and apoptosis of OS cells.

IL-1R1 and IL-18 Signals Regulate Mesenchymal Stromal Cells in an Aged Murine Model of Myelodysplastic Syndromes

January 22, 2025

[Blood] Utilizing highly purified primary bone marrow-derived MSCs, both interleukin (IL)-1b and IL-18 were found to exert direct effects on MSCs, thus influencing their ability to support hematopoietic stem and progenitor cells as well as erythroid progenitors.

Exosomal miR-21-5p from Glioma Associated Mesenchymal Stem Cells Promotes the Progression and Glycolysis of Glioblastoma via PDHA1

January 21, 2025

[Scientific Reports] The authors explored the relationship between glioma associated MSC-derived exosomes and pyruvate dehydrogenase A1 (PDHA1), as well as the effects and mechanisms on glioblastoma glucose metabolism.

Polycystin-1 Regulates Tendon-Derived Mesenchymal Stem Cells Fate and Matrix Organization in Heterotopic Ossification

January 20, 2025

[Bone Research] Researchers showed that the mechanical protein Polysyctin-1 regulated CTSK lineage tendon-derived MSC fate and extracellular matrix organization, thus affecting heterotopic ossification progression.

hsa_circ_0001599 Promotes Odontogenic Differentiation of Human Dental Pulp Stem Cells by Increasing ITGA2 Expression and Stability

January 17, 2025

[Communications Biology] Investigators elucidated the molecular mechanism by which hsa_circ_0001599 worked in human dental pulp stem cells during odontogenic differentiation.

Combination of Rapamycin and Adipose-Derived Mesenchymal Stromal Cells Enhances Therapeutic Potential for Osteoarthritis

January 16, 2025

[Stem Cell Research & Therapy] Scientists evaluated a novel approach to osteoarthritis treatment by combining adipose tissue-derived MSCs with rapamycin, a clinically approved immunosuppressive drug with anti-senescence properties.

FOXG1 Promotes Osteogenesis of Bone Marrow-Derived Mesenchymal Stem Cells by Activating Autophagy through Regulating USP14

January 15, 2025

[Communications Biology] Forkhead Box Protein G1 (FOXG1) expression in bone marrow-derived MSCs increased after osteogenic induction. FOXG1 overexpression significantly increased osteoblast marker expression ALP activity, and calcium deposition.

3D Printing of Different Fibers Towards HA/PCL Scaffolding Induces Macrophage Polarization and Promotes Osteogenic Differentiation of BMSCs

January 14, 2025

[PLOS One] Investigators applied 3D printing technology to prepare three sets of HA/PCL scaffolds with different fibre orientations to study the differences in physicochemical properties.

Osterix mRNA Enrichment in Small Extracellular Vesicles Derived from Osteogenically Induced ADSCs: A Promoter of Osteogenic Differentiation in BMSCs

January 14, 2025

[Journal of Cellular and Molecular Medicine] Researchers investigated the mRNA expression profile of adipose mesenchymal stem cell-small extracellular vesicles+ and explored the role of specific mRNAs in the osteogenic differentiation of bone marrow stem cells.

Counterregulatory Roles of GLI2 and GLI3 in Osteogenic Differentiation via Gli1 Expression

January 14, 2025

[Journal of Cell Science] From the MSC line C3H10T1/2, scientists established Gli2-knockout (KO) and Gli3-KO cells, and constitutively GLI3R-producing cells, and expressed GLI1, GLI2, and GLI3 constructs in these cells.

Ongoing Chromothripsis Underpins Osteosarcoma Genome Complexity and Clonal Evolution

January 14, 2025

[Cell] Using multi-region whole-genome sequencing, investigators found that chromothripsis was an ongoing mutational process, occurring subclonally in 74% of osteosarcomas.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.