Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Human Gingival Mesenchymal Stem Cells Retain Their Growth and Immunomodulatory Characteristics Independent of Donor Age

June 28, 2022

[Science Advances] Investigators explored the possibility of using MSCs derived from human gingival tissues for studying their ex vivo growth characteristics and differentiation potential with respect to donor age.

Enhancement of Lymphangiogenesis by Human Mesenchymal Stem Cell Sheet

June 28, 2022

[Advanced Healthcare Materials] Scientists evaluated the ability of human MSC (hMSC)-secreted extracellular matrix to augment lymphangiogenesis by using an in vitro co-culturing model of hMSC sheets with lymphatic endothelial cells (LECs) and an in vivo mouse tail lymphedema model.

Exosomes from Human Adipose-Derived Mesenchymal Stromal/Stem Cells Accelerate Angiogenesis in Wound Healing: Implication of the EGR-1/lncRNA-SENCR/DKC1/VEGF-A Axis

June 28, 2022

[Human Cell] Researchers isolated human adipose-MSCs, and enriched early growth response factor-1, Smooth muscle and endothelial cell migration/differentiation-associated long-noncoding RNA (lncRNA-SENCR), and achived vascular endothelial growth factor-A (VEGF-A) overexpression or knockdown.

Epigenetic Regulation of NGF-Mediated Osteogenic Differentiation in Human Dental Mesenchymal Stem Cells

June 28, 2022

[Stem Cells] Using human dental MSCs, the authors demonstrated that nerve growth factor (NGF) mediated osteogenic differentiation through p75NTR, a low-affinity nerve growth factor receptor.

The Neuroprotective Effect of Mesenchymal Stem Cells in Colistin-Induced Neurotoxicity

June 28, 2022

[Toxicology Mechanisms and Methods] Researchers assessed the potential protective effects of MSC, against colistin-induced neurotoxicity, and the possible mechanisms underlying any effect.

Glucose Metabolism: Optimizing Regenerative Functionalities of Mesenchymal Stromal Cells Post-Implantation

June 28, 2022

[Tissue Engineering Part B-Reviews] Investigators report that glucose is the primary energy substrate for MSCs, provides precursors for biomass generation, and regulates MSC functions, including proliferation, differentiation, and immunosuppressive properties.

Lipid Nanoparticle Mediated Silencing of Osteogenic Suppressor GNAS Leads to Osteogenic Differentiation of Mesenchymal Stem Cells In Vivo

June 28, 2022

[Molecular Therapy] The authors examined the ability of small interfering RNA to enhance osteoblast differentiation and bone formation by silencing the negative suppressor gene GNAS in bone MSCs.

Enhanced PDGFR/Wnt/β-Catenin Activity of Mesenchymal Stem Cells with High Migration Ability Rescue Bone Loss of Osteoporosis

June 28, 2022

[Cellular Signalling] Scientists proposed a novel method to screen MSCs with high migration capacity and confirmed that these MSCs exhibited higher osteogenic differentiation ability both in vivo and in vitro.

In Vitro Exposure to Inflammatory Mediators Affects the Differentiation of Mesenchymal Progenitors

June 28, 2022

[Frontiers in Bioengineering and Biotechnology] Human MSCs were cultured in the presence of inflammatory mediators typically associated with osteoarthritis pathology.

Mice with Trp53 and Rb1 Deficiency in Chondrocytes Spontaneously Develop Chondrosarcoma via Overactivation of YAP Signaling

June 28, 2022

[Cell Death & Disease] Researchers generated a new transgenic chondrosarcoma model by double conditional deletions of Trp53 and Rb1 in chondrocyte lineage which spontaneously caused spinal chondrosarcoma and lung metastasis.

Comparative Efficacy and Mechanism of Action of Cardiac Progenitor Cells after Cardiac Injury

June 27, 2022

[iScience] Transplanted neonatal mesenchymal stem cells significantly increased the number of tissue reparative macrophages and regulatory T cells and decreased monocyte-derived inflammatory macrophages and neutrophils in the host myocardium.

Effects of Mesenchymal Stem Cell Transplantation on Spinal Cord Injury Patients

June 27, 2022

[Cell and Tissue Research] Investigators review the beneficial effects of mesenchymal stem cell (MSC) transplantation in spinal cord injury clinical studies with a special focus on the MSC properties and limitations of MSC transplantation.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.