Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

The Transmembrane Protein TM4SF3 Interacts with AR and AR-V7 and is Recruited to AR Target Genes

[Endocrinology] Scientists mapped the interaction domains within the androgen receptor (AR) and transmembrane 4 superfamily 3 (TM4SF3) and discovered that TM4SF3 also physically interacted with AR-V7, regulating its protein stability and the viability of castration-resistant prostate cancer cells expressing AR-V7.

O2 Variant Chip to Simulate Site-Specific Skeletogenesis from Hypoxic Bone Marrow

[Science Advances] Scientists cultured bone marrow mesenchymal stem cells in a 3D chip and implanted them into rabbit defect models of low-oxygen cartilage and high-oxygen calvaria bone in order to simulate site-specific skeletogenesis from hypoxic bone marrow.

Splicing Factor YBX1 Regulates Bone Marrow Stromal Cell Fate during Aging

[EMBO Journal] The authors found that the expression of the splicing factor Y-box binding protein 1 (YBX1) in bone marrow stem cells (BMSCs) decreased with aging in mice and humans. YBX1 deficiency resulted in mis-splicing in genes linked to BMSC osteogenic differentiation and senescence, such as Fn1, Nrp2, Sirt2, Sp7, and Spp1, thus contributing to BMSC senescence and differentiation shift during aging.

Placental Mesenchymal Stem Cells Ameliorate NLRP3 Inflammasome-Induced Ovarian Insufficiency by Modulating Macrophage M2 Polarization

[Journal of Ovarian Research] Injection of human placental MSCs improved ovarian function and reproductive ability of premature ovarian insufficiency rats compared to the sham and hormone groups.

Human Umbilical-Cord-Derived Mesenchymal Stem Cells in Combination with Rapamycin Reduce Cartilage Degradation via Inhibition of the AKT/mTOR Signaling Pathway

[Immunopharmacology And Immunotoxicology] Scientists explored the role of rapamycin combined with human umbilical-cord-derived MSCs in osteoarthritis (OA)rabbits in vivo. OA rabbits received an intra-articular injection of a collagenase solution.

Identification of Key Pathways in Zirconia/Dental Pulp Stem Cell Composite Scaffold-Mediated Macrophage Polarization through Transcriptome Sequencing

[Biotechnology and Genetic Engineering Reviews] DPSCs were seeded onto N-rGO/ZrO2 composite scaffold material, and their proliferation, adhesion, and osteogenic differentiation were evaluated by CCK-8, immunofluorescence staining, ALP staining, and alizarin red staining.

Neuroprotective Mechanism of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Improving the Phenotype Polarization of Microglia via the PI3K/AKT/Nrf2 Pathway in Vascular Dementia

[Synapse] Vascular dementia (VaD) rat model was established by bilateral common carotid artery ligation andhuman umbilical cord MSC derived extraellular vesicles (EVs) were extracted. VaD rats were injected with Evs through the tail vein.

Identification of Molecularly Unique Tumor-Associated Mesenchymal Stromal Cells in Breast Cancer Patients

[PLOS One] The authors identified CD90+ MSCs residing in the tumor microenvironment of patients with invasive breast cancer that exhibit a unique gene expression signature.

Research Trends and Hotspots of Mesenchymal Stromal Cells in Intervertebral Disc Degeneration: A Scientometric Analysis

[Efort Open Reviews] Investigators summarize the main research trends, identify current research hotspots, and measure the networks of the contributors and their scientific productivity.

Sarah Peters Named the First Recipient of AADOCR William Butler Fellowship

[AADOCR] The American Association for Dental, Oral, and Craniofacial Research (AADOCR) named Sarah Peters, The Ohio State University, Columbus the 2023 recipient of the new AADOCR William Butler Fellowship. She has over 15 years of experience developing new methods and materials in a wide range of laboratory settings.

A Single-Cell Census of Mouse Limb Development Identifies Complex Spatiotemporal Dynamics of Skeleton Formation

[Developmental Cell] In vivo lineage tracing confirmed this role and localized the naive progenitors to the outer margin of the limb, along the anterior-posterior axis.

Wnt Signaling from Gli1-Expressing Apical Stem/Progenitor Cells Is Essential for the Coordination of Tooth Root Development

[Stem Cell Reports] Loss of Wnt production in Gli1+ apical stem/progenitor cells led to loss of Axin2 at the root apex, mis-regulation of SOX9, loss of BMP and Hh signaling, and truncation of root development. In the absence of Wnt signals, the root epithelium lost its integrity and epithelial identity.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.