Cancer Stem Cell News
Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
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Mesenchymal Stem Cell Therapy for Systemic Sclerosis: Current Evidence and Clinical Applications
[Stem Cell Reviews and Reports] MSC therapy has gained interest as a disease-modifying strategy because its therapeutic activity appears to depend largely on paracrine signaling rather than durable engraftment. Through these mechanisms, MSCs may suppress profibrotic fibroblast activation, and recalibrate innate and adaptive immune responses.
Glycocalyx-Edited Mesenchymal Stem/Stromal Cell Therapy in Advanced Osteoporosis
[Cell] Researchers conducted a first-in-human clinical trial involving a single intravenous infusion of glycocalyx-edited autologous bone marrow-derived MSCs in ten women with advanced-stage osteoporosis
Carbon Dots Enhance Efferocytosis via MSC-Macrophage Crosstalk: A New Strategy for Diabetic Bone Regeneration
[Small] Scientists revealed that bifunctional carbon dots restore MSC function by reactivating autophagic flux, thereby simultaneously enhancing osteogenic differentiation and immunomodulatory capacity.
Olfactory Mucosa-Derived Mesenchymal Stem Cells Differentiate Towards a Schwann Cell-Like Phenotype for Peripheral Nerve Regeneration
[Scientific Reports] The authors presented the first investigation of scaffold-free, defined-media differentiation of olfactory mucosa-derived MSCs (OM-MSCs) towards a Schwann cell (SC)-like phenotype. They highlight the potential of OM-MSCs to be expanded and differentiated to SCs to improve synthetic scaffolds.
IGFBP5 Alleviates Periodontitis by Reversing Human Dental Follicle Stem Cell Senescence via the Non-Canonical Wnt Pathway
[International Journal of Oral Science] Researchers observed a significant decrease in insulin-like growth factor binding protein 5 (IGFBP5) expression in dental follicle stem cells undergoing replicative or H₂O₂-induced senescence.
Ernexa Therapeutics Reports Positive Disease Modifying ERNA-201 Preclinical Data, Reinforcing iMSC Platform as Company Accelerates Oncology Strategy and ERNA-101 Toward First-in-Human Dosing
[Ernexa Therapeutics] Ernexa Therapeutics announced preliminary preclinical results for ERNA-201, its synthetic, allogeneic induced MSC therapy engineered to express anti inflammatory factors.
Retinoic Acid-Treated Human Umbilical Cord-Derived Mesenchymal Stem Cells Attenuate Alzheimer’s Disease in an Animal Model
[Scientific Reports] Investigators evaluated the effects of retinoic acid-treated human umbilical cord-derived MSCs on Alzheimer’s disease-associated pathological and functional changes in a mouse model of Alzheimer’s disease.
Engineered Mechanosensitive MSCs Enable Synthetic Radiotheranostic Targeting across Tumor Types
[Cell Stem Cell] Researchers presented a stiffness-responsive MSC-assisted relayed tumor-targeting platform that converts matrix stiffness into a programmable molecular entry point for radiotheranostics. This platform is readily adaptable to alternative synthetic targets and iPSC-derived MSCs.
Alveolar Epithelial Depletion of βPAK-Interacting Exchange Factor Drives Spontaneous Pulmonary Fibrosis by Impairing Stemness
[Signal Transduction and Targeted Therapy] Investigators generated conditional βPIX knockout mice to investigate its contribution to PF pathogenesis, finding progenitor cells in a transitional stem cell state with senescent attributes, along with active, collagen-producing myofibroblasts.
Chronic E-Cigarette Aerosol Exposure Alters NRF2 and TGF-β1 Signaling and Enhances Stem-Like Features in Human Oral and Lung Epithelial Cells
[Ecotoxicology and Environmental Safety] Scientists investigated how prolonged exposure to e-cigarette aerosols affect key cellular pathways involved in antioxidant defense and stemness in human oral and lung epithelial cells.
A Stem-Like Chromatin Program in Small-Cell Lung Cancer Is Associated with Poor Outcomes after Chemoimmunotherapy
[Cell Reports Medicine] Scientists profiled tumor-intrinsic chromatin accessibility in a patient-derived xenograft biobank and identified recurrent chromatin programs: neuroendocrine, marked by ASCL1/NEUROD1 activity; immunogenic, marked by IRF-associated activity; and stem-like, marked by TEAD/OCT activity.
KRAS/ERK2-Driven Stabilization of AARS1 Reprograms Tumor Metabolism and Confers Sorafenib Resistance in Lung Adenocarcinoma
[Cell Death & Differentiation] Scientists identified alanyl-tRNA synthetase 1 (AARS1) as a previously unrecognized metabolic effector of KRAS signaling, highlighting the therapeutic potential of targeting AARS1 phosphorylation to overcome drug resistance in lung adenocarcinoma.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
