Mesenchymal Stromal Cells Mitigate Liver Damage after Extended Resection in the Pig by Modulating Thrombospondin-1/TGF-β

The authors suggested that mesenchymal stromal cells ameliorated surgery-induced hepatocellular stress and epithelial-mesenchymal transition, thus supporting epithelial integrity and facilitating regeneration.
[NPJ Regenerative Medicine]
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Mesenchymal Stem Cell Therapy in Decompensated Liver Cirrhosis: A Long-Term Follow-Up Analysis of the Randomized Controlled Clinical Trial

Therapy of umbilical cord-derived MSC was not only well tolerated, but also significantly improved long-term survival rate, as well as the liver function in patients with Hepatits B Virus-related decompensated liver cirrhosis.
[Hepatology International]
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AgeX Therapeutics’ Licensee ImStem Biotechnology Announces First US Multiple Sclerosis Patient Dosed with IMS001

AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc., a biopharmaceutical company developing human ESC-derived mesenchymal stem cells, has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.
[AgeX Therapeutics, Inc.]
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AgeX Therapeutics’ Licensee ImStem Biotechnology Announces First U.S. Multiple Sclerosis Patient Dosed with IMS001

AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc. has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.
[AgeX Therapeutics, Inc. (BusinessWire, Inc.)]
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Human Adipose-Derived Stromal/Stem Cells Expressing Doublecortin Improve Cartilage Repair in Rabbits and Monkeys

Scientists expressed doublecortin (DCX) in human adipose-derived stromal/stem cells (hASCs) and engineered hASCs into cartilage tissues. They found that DCX expression in hASCs increased expression of growth differentiation factor 5 and matrilin 2 in the engineered cartilage tissues.
[NPJ Regenerative Medicine]
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Increased Proliferation and Differentiation Capacity of Placenta-Derived Mesenchymal Stem Cells from Women of Median Maternal Age Correlates with Telomere Shortening

Researchers investigated the effect of maternal age on the biological characteristics and stemness properties of placenta-derived MSCs (PDMSCs). PDMSCs were isolated from 5 donor age groups for comparison of morphological, proliferative and differentiation properties.
[Aging]
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Angle-Ply Scaffold Supports Annulus Fibrosus Matrix Expression and Remodeling by Mesenchymal Stromal and Annulus Fibrosus Cells

A collagen-based, angle-ply multilaminate patch designed to repair the outer annulus fibrosus was assessed for its ability to support mesenchymal stromal and annulus fibrosus cell viability, elongation, alignment, extracellular matrix gene expression, and scaffold remodeling.
[Journal of Biomedical Materials Research Part B-Applied Biomaterials]
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JAZF1, YWHAE, and BCOR Gene Translocation in Primary Extrauterine Low-Grade and High-Grade Endometrial Stromal Sarcomas

In extrauterine low-grade endometrial stromal sarcoma (LG-ESS), the positive rate of JAZF1 gene rearrangement was significantly lower than in uterine LG-ESS, limiting the value of JAZF1 gene translocation for diagnosis.
[Histopathology]
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Cartilaginous Extracellular Matrix Enriched with Human Gingival Mesenchymal Stem Cells Derived “Matrix Bound Extracellular Vesicles” Enabled Functional Reconstruction of Tracheal Defect

Coculturing chondrocytes with MSCs derived from gingival lamina propria produced abundant “matrix bound gingival MSC derived extracellular vesicles” in forming cartilaginous extracellular matrix (ECM), which were further preserved in acellular cartilaginous ECM following mild, short-period decellularization.
[Advanced Science]
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Role of EZH2 in Bone Marrow Mesenchymal Stem Cells and Immune-Cancer Interactions

The authors review the role of enhancer of zeste homology 2 (EZH2) in regulating bone marrow MSC differentiation and the immune cell function in tumor microenvironment, summarize all types of existing EZH2 inhibitors and the main clinical trials, and propose relevant ideas for potential clinical applications.
[Critical Reviews in Oncology/Hematology]
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Bone Morphogenetic Protein 9 Enhances Osteogenic and Angiogenic Responses of Human Amniotic Mesenchymal Stem Cells Cocultured with Umbilical Vein Endothelial Cells through the PI3K/AKT/M-TOR Signaling Pathway

The authors investigated the effects of bone morphogenetic protein 9 on osteogenesis and angiogenesis of human amniotic mesenchymal stem cells (hAMSCs) cocultured with human umbilical vein endothelial cells (HUVECs) and determined the possible underlying molecular mechanism.
[Aging]
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