Mesenchymal Stem Cells and Exosome Therapy for COVID-19: Current Status and Future Perspective

The authors explored the therapeutic potential of both mesenchymal stem cells and exosomes in mitigating the COVID-19 induced cytokine storm as well as promoting the regeneration of alveolar tissue, attributed to the intrinsic cytokines and growth factor present in the secretome.
[Human Cell]
Gupta, A., Kashte, S., Gupta, M., Rodriguez, H. C., Gautam, S. S., & Kadam, S. (2020). Mesenchymal stem cells and exosome therapy for COVID-19: current status and future perspective. Human Cell. https://doi.org/10.1007/s13577-020-00407-w Cite
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The Role of Selenium Metabolism and Selenoproteins in Cartilage Homeostasis and Arthropathies

Scientists discuss the potential of therapeutic strategies targeting the biological functions of selenium and selenoproteins for osteoarthritis treatment.
[Experimental and Molecular Medicine]
Kang, D., Lee, J., Wu, C., Guo, X., Lee, B. J., Chun, J.-S., & Kim, J.-H. (2020). The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies. Experimental & Molecular Medicine, 1–11. https://doi.org/10.1038/s12276-020-0408-y Cite
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Adipose Derived Mesenchymal Stem Cell Exosomes Loaded with miR-10a Promote the Differentiation of Th17 and Treg from Naive CD4+ T Cell

Exosomes isolated form adipose tissue derived mesenchymal stem cells were transfected with miR-10a and added to naïve T cells purified from mouse spleen.
[Life Sciences]
Bolandi, Z., Mokhberian, N., Eftekhary, M., Sharifi, K., Soudi, S., Ghanbarian, H., & Hashemi, S. M. (2020). Adipose derived mesenchymal stem cell exosomes loaded with miR-10a promote the differentiation of Th17 and Treg from naive CD4+ T cell. Life Sciences, 118218. https://doi.org/10.1016/j.lfs.2020.118218 Cite
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GMP-Compliant Sponge-Like Dressing Containing MSC Lyo-Secretome: Proteomic Network of Healing in a Murine Wound Model

Investigators prove that the in vivo activity of the whole secretome formulated in a sponge-like alginate wound dressing to obtain the controlled release of bioactive substances.
[European Journal of Pharmaceutics and Biopharmaceutics]
Elia, B., Silvestre Dario, D., Luca, M., Federica, G., Pietro, G., Giorgio, M., Marta, N., Maddalena, M., Marzio, S., Rossana, R., Maria Luisa, T., Pierluigi, M., Giovanni, S., & Sara, P. (2020). GMP-compliant sponge-like dressing containing MSC lyo-secretome: proteomic network of healing in a murine wound model. European Journal of Pharmaceutics and Biopharmaceutics. https://doi.org/10.1016/j.ejpb.2020.08.003 Cite
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Mesenchymal Stem Cell-Derived Extracellular Vesicles for the Promotion of Tendon Repair – an Update of Literature

The author reviews the recent literature on the promotion of tendon repair using extracellular vesicles-derived from MSCs. The mechanisms underlying these actions are also reviewed and future research directions are discussed.
[Stem Cell Reviews and Reports]
Lui, P. P. Y. (2020). Mesenchymal Stem Cell-Derived Extracellular Vesicles for the Promotion of Tendon Repair - an Update of Literature. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10023-8 Cite
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Heparin/Collagen Surface Coatings Modulate the Growth, Secretome and Morphology of Human Mesenchymal Stromal Cell Response to Interferon-Gamma

Scientists examined the impact of heparin and collagen I multilayers on the growth, morphology and secretome of bone marrow and adipose-derived human mesenchymal stromal cells.
[Journal of Biomedical Materials Research Part A]
Cifuentes, S. J., Priyadarshani, P., Castilla‐Casadiego, D. A., Mortensen, L. J., Almodóvar, J., & Domenech, M. (n.d.). Heparin/Collagen Surface Coatings Modulate the Growth, Secretome and Morphology of Human Mesenchymal Stromal Cell Response to Interferon-Gamma. Journal of Biomedical Materials Research Part A, n/a(n/a). https://doi.org/10.1002/jbm.a.37085 Cite
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Inhibition of Axin1 in Osteoblast Precursor Cells Leads to Defects in Postnatal Bone Growth through Suppressing Osteoclast Formation

Osteoclast formation in primary bone marrow derived microphage (BMM) cells was significantly decreased when BMM cells were cultured with conditioned media (CM) collected from osteoblasts derived from Axin1Osx mice compared with BMM cells cultured with CM derived from WT mice.
[Bone Research]
Shu, B., Zhao, Y., Zhao, S., Pan, H., Xie, R., Yi, D., Lu, K., Yang, J., Xue, C., Huang, J., Wang, J., Zhao, D., Xiao, G., Wang, Y., & Chen, D. (2020). Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation. Bone Research, 8(1), 1–8. https://doi.org/10.1038/s41413-020-0104-5 Cite
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Impact of Low-Intensity Pulsed Ultrasound on Transcription and Metabolite Compositions in Proliferation and Functionalization of Human Adipose-Derived Mesenchymal Stromal Cells

Researchers investigated the effect of low-intensity pulsed ultrasound on the proliferation of human adipose-derived mesenchymal stromal cells and uncovered its stimulation mechanism.
[Scientific Reports]
Huang, D., Gao, Y., Wang, S., Zhang, W., Cao, H., Zheng, L., Chen, Y., Zhang, S., & Chen, J. (2020). Impact of low-intensity pulsed ultrasound on transcription and metabolite compositions in proliferation and functionalization of human adipose-derived mesenchymal stromal cells. Scientific Reports, 10(1), 13690. https://doi.org/10.1038/s41598-020-69430-z Cite
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Evidence of Mesenchymal Stromal Cell Adaptation to Local Microenvironment Following Subcutaneous Transplantation

Researchers showed that upon subcutaneous transplantation in mice, MSC formed multicellular aggregates and did not migrate significantly from the site of injection.
[Journal of Cellular and Molecular Medicine]
Preda, M. B., Lupan, A.-M., Neculachi, C. A., Leti, L. I., Fenyo, I. M., Popescu, S., Rusu, E. G., Marinescu, C. I., Simionescu, M., & Burlacu, A. (n.d.). Evidence of mesenchymal stromal cell adaptation to local microenvironment following subcutaneous transplantation. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15717 Cite
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Magnetic Resonance Imaging of Umbilical Cord Stem Cells Labeled with Superparamagnetic Iron Oxide Nanoparticles: Effects of Labeling and Transplantation Parameters

Scientists examined the umbilical cord-MSCs labeled with superparamagnetic and ultrasmall superparamagnetic iron oxide in terms of cell functioning and imaging efficiency in vitro and in vivo.
[Scientific Reports]
Ohki, A., Saito, S., & Fukuchi, K. (2020). Magnetic resonance imaging of umbilical cord stem cells labeled with superparamagnetic iron oxide nanoparticles: effects of labelling and transplantation parameters. Scientific Reports, 10(1), 13684. https://doi.org/10.1038/s41598-020-70291-9 Cite
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Wharton’s Jelly Mesenchymal Stem Cells Exosomes and Conditioned Media Increased Neutrophil Lifespan and Phagocytosis Capacity

Scientists showed that following in vitro expansion, Wharton’s jelly MSCs were more effective than other sources of MSCs. Cell to cell contact or secretion of soluble factors and exosomes were the main approaches of MSCs in applying their effects.
[Immunological investigations]
Taghavi-Farahabadi, M., Mahmoudi, M., Rezaei, N., & Hashemi, S. M. (2020). Wharton’s Jelly Mesenchymal Stem Cells Exosomes and Conditioned Media Increased Neutrophil Lifespan and Phagocytosis Capacity. Immunological Investigations, 0(0), 1–16. https://doi.org/10.1080/08820139.2020.1801720 Cite
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Discarded Plasma Obtained after Cord Blood Volume Reduction as an Alternative for Fetal Calf Serum in Mesenchymal Stromal Cells Cultures

The amplification of the MSCs and mesenchymal progenitors was estimated in the presence of serum derived from umbilical cord blood plasma and its cytokine content was determined by cytometric bead array and enzyme‐linked immunosorbent assay techniques.
[Transfusion]
Vlaski‐Lafarge, M., Chevaleyre, J., Cohen, J., Ivanovic, Z., & Lafarge, X. (n.d.). Discarded plasma obtained after cord blood volume reduction as an alternative for fetal calf serum in mesenchymal stromal cells cultures. Transfusion, n/a(n/a). https://doi.org/10.1111/trf.15920 Cite
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