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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Senescence-Resistant Human Mesenchymal Progenitor Cells Counter Aging in Primates
[Cell] In a 44-week trial, scientists intravenously delivered senescence-resistant human mesenchymal progenitor cells to aged macaques, noting a systemic reduction in aging indicators, such as cellular senescence, chronic inflammation, and tissue degeneration, without any detected adverse effects.
Synergistic Potential of Bone Marrow Mesenchymal Stem Cells and mir181-A Combinational Therapy against Multiple Sclerosis
[Stem Cell Research & Therapy] Researchers proposed a synergistic therapy approach that combines the penetrative targeting capability of bone marrow MSCs (BMSCs) with the immuno-modulatory effects of miR181-a by overexpressing miR181-a to BMSCs through lentivirus packaging system.
CircRNA_1809 Promotes the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells through Mir-370-3p
[Scientific Reports] Investigators used gene knockdown/overexpression and siRNA transfection to evaluate the regulatory effects of circRNA_1809 on the miR-370-3p/Kitlg pathway and the osteogenic differentiation of rat bone marrow MSCs in vitro.
EIF4A3 Enhances the Viability, Invasion, and Osteogenic Differentiation of BMSCs via the USP53/SMAD5 Pathway
[Scientific Reports] Researchers proposed and demonstrated that eukaryotic translation initiation factor 4A3 (EIF4A3) promoted osteogenic differentiation of bone marrow MSCs via ubiquitin-specific peptidase 53 (USP53)/SMAD5 axis,
Multi-Omics Analysis of Canine Aging Markers and Evaluation of Stem Cell Intervention
[Communications Biology] Scientists demonstrated that MSCs, particularly those overexpressing nicotinamide nucleotidyl adenosine transferase 1, can delay or reverse aging in dogs.
PRMT1 Inhibition Enhances the Cardioprotective Effect of Adipose-Derived Mesenchymal Stem Cells against Myocardial Infarction through RUNX1
[Stem Cell Research & Therapy] Scientists investigate the effect of protein arginine methyltransferase 1 (PRMT1 ) on MSC function and therapeutic efficacy using a mouse myocardial infarction model.
Deciphering the Distinct Roles of Molecular and Supramolecular Chirality in Osteogenic Differentiation of Mesenchymal Stem Cells in 3D Hydrogels
[ACS Nano] Scientists employed a strategy using nanostructures with controlled chirality to precisely assess the impact of molecular and supramolecular chirality on mesenchymal stem cell (MSC) osteogenic differentiation.
Aged and BRCA-Mutated Stromal Cells Drive Epithelial Cell Transformation
[Cancer Discovery] Scientists reported that an epigenetically altered MSC niche, termed high-risk mesenchymal stromal/stem cells, exists prior to serous tubal intraepithelial carcinoma lesion formation.
Clinical Application of Mesenchymal Stem Cells in Immunosenescence: A Qualitative Review of Their Potential and Challenges
[Stem Cell Research & Therapy] MSCs, a type of multipotent stromal cells with regenerative potential, low immunogenicity, and strong immunomodulatory properties-are increasingly recognized as a promising therapeutic option to reverse or alleviate immunosenescence-related dysfunction.
Immutep’s Efti with Radiotherapy & KEYTRUDA® (pembrolizumab) Meets Primary Endpoint in Phase II for Soft Tissue Sarcoma
[Immutep Limited ] Immutep Limited announced the investigator-initiated EFTISARC-NEO Phase II trial evaluating eftilagimod alfa with radiotherapy plus KEYTRUDA® in the neoadjuvant setting for resectable soft tissue sarcoma has met its primary endpoint.
Loading Tea Polyphenols Enhances the Repair of Human Umbilical Cord Mesenchymal Stem Cell Sheet after Spinal Cord Injury
[Stem Cell Research & Therapy] Scientists constructed human umbilical cord MSC sheet loaded with tea polyphenols and evaluated their therapeutic effects and mechanisms both in vitro and in vivo in spinal cord injury rats.
Intravenous Mesenchymal Stem Cell Transplantation Mitigates Pulmonary Vascular Remodeling but Poses Dose Related Risks in a Pulmonary Veno-Occlusive Disease Model
[Stem Cell Research & Therapy] Researchers analyzed the effects of adipose-derived MSC transplantation in a rat model of pulmonary veno-occlusive disease.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
