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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Alveolar Epithelial Depletion of βPAK-Interacting Exchange Factor Drives Spontaneous Pulmonary Fibrosis by Impairing Stemness
[Signal Transduction and Targeted Therapy] Investigators generated conditional βPIX knockout mice to investigate its contribution to PF pathogenesis, finding progenitor cells in a transitional stem cell state with senescent attributes, along with active, collagen-producing myofibroblasts.
Chronic E-Cigarette Aerosol Exposure Alters NRF2 and TGF-β1 Signaling and Enhances Stem-Like Features in Human Oral and Lung Epithelial Cells
[Ecotoxicology and Environmental Safety] Scientists investigated how prolonged exposure to e-cigarette aerosols affect key cellular pathways involved in antioxidant defense and stemness in human oral and lung epithelial cells.
A Stem-Like Chromatin Program in Small-Cell Lung Cancer Is Associated with Poor Outcomes after Chemoimmunotherapy
[Cell Reports Medicine] Scientists profiled tumor-intrinsic chromatin accessibility in a patient-derived xenograft biobank and identified recurrent chromatin programs: neuroendocrine, marked by ASCL1/NEUROD1 activity; immunogenic, marked by IRF-associated activity; and stem-like, marked by TEAD/OCT activity.
KRAS/ERK2-Driven Stabilization of AARS1 Reprograms Tumor Metabolism and Confers Sorafenib Resistance in Lung Adenocarcinoma
[Cell Death & Differentiation] Scientists identified alanyl-tRNA synthetase 1 (AARS1) as a previously unrecognized metabolic effector of KRAS signaling, highlighting the therapeutic potential of targeting AARS1 phosphorylation to overcome drug resistance in lung adenocarcinoma.
Tumor-Intrinsic NSUN2 Orchestrates Immunosuppression in Lung Adenocarcinoma via the Mc-HDAC8-CCL5 Axis
[Experimental Hematology & Oncology] Investigators identified the tumor-intrinsic m5C methyltransferase, NSUN2, as a critical orchestrator of T-cell exclusion in lung adenocarcinoma, serving as a candidate predictive biomarker for immune checkpoint inhibitor failure and a promising druggable target.
Early-Stage Non-Small-Cell Lung Cancer: Emerging Treatments and Evolving Challenges
[Lancet Respiratory Medicine] In this first of a three paper series, scientists discuss how advances in the treatment of early-stage non-small-cell lung cancer have introduced uncertainties regarding optimal sequencing, treatment duration, patient selection, and the role of treatment escalation or de-intensification with immunotherapy and targeted therapies.
Mechanical Control in Dental and Jaw Morphogenesis and Remodeling
[International Journal of Oral Science] The authors elaborate on the regulatory roles and underlying molecular mechanisms of mechanical signals in key dentofacial developmental processes, including crown development, root morphogenesis, tooth eruption and replacement, as well as maxillomandibular bone development and remodeling.
Rutledge Cancer Foundation’s $1.5 Million ACES Grant Fuels Groundbreaking Research to Advance New Treatments for Ewing Sarcoma
[RCF] Rutledge Cancer Foundation (RCF) is advancing an ambitious new approach to Ewing sarcoma research through its $1.5 million ACES Grant, a three-year initiative bringing together leading researchers from John Hopkins and National Institutes of Health to pursue new treatment strategies.
Engineered Mechanosensitive MSCs Enable Synthetic Radiotheranostic Targeting across Tumor Types
[Cell Stem Cell] Scientists presented a stiffness-responsive MSC-assisted relayed tumor-targeting platform that converts matrix stiffness into a programmable molecular entry point for radiotheranostics.
Human iPSC-Derived Mesenchymal Progenitor Cell Sheets Promote Tissue Formation after Xenotransplantation
[iScience] Researchers investigated whether sheets derived from hiPSC-derived mesenchymal progenitor cells (MPCs) can survive and form tissue-like structures after xenotransplantation. demonstrate that hiPS-MPC sheets generate vascularized tissues in vivo and support survival across species.
Dental Pulp Stem Cells Transfer Mitochondria via Tunneling Nanotubes to Drive Hypoxic Angiogenesis
[Journal of Dental Research] Scientists identified intercellular mitochondrial transfer from dental pulp stem cells to endothelial cells as a critical survival and angiogenic mechanism under hypoxic stress.
Mesenchymal Stromal Cell-Based Cell-Drug Conjugates for the Treatment of Acute Liver Failure
[Advanced Science] Investigators combined the anti-inflammatory small-molecule rosiglitazone with MSCs to construct a cell–drug conjugate using MSCs as cellular carriers. Rosiglitazone was encapsulated within nanoparticles coated with neutrophil membranes and anchored onto the MSC surface.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
