Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Comparative Efficacy and Mechanism of Action of Cardiac Progenitor Cells after Cardiac Injury

[iScience] Transplanted neonatal mesenchymal stem cells significantly increased the number of tissue reparative macrophages and regulatory T cells and decreased monocyte-derived inflammatory macrophages and neutrophils in the host myocardium.

Effects of Mesenchymal Stem Cell Transplantation on Spinal Cord Injury Patients

[Cell and Tissue Research] Investigators review the beneficial effects of mesenchymal stem cell (MSC) transplantation in spinal cord injury clinical studies with a special focus on the MSC properties and limitations of MSC transplantation.

Intravenously Transplanted Mesenchymal Stromal Cells: A New Endocrine Reservoir for Cardioprotection

[Stem Cell Research & Therapy] MSCs were isolated from human placenta tissue, and DF-MSCs or Gluc-MSCs were generated by transduced with firefly luciferase/enhanced green fluorescence protein or Gaussia luciferase lactadherin fusion protein.

BioRestorative Therapies Announces Clinical Trial Contract with Second Site for the Company’s Phase II Clinical Trial to Treat Chronic Lumbar Disc Disease (cLDD)

[BioRestorative Therapies, Inc.] BioRestorative Therapies, Inc. announced it has reached an agreement with its second clinical site for its Phase II clinical trial targeting chronic lumbar disc disease.

Efficient Engineering of Human Auricular Cartilage through Mesenchymal Stem Cell Chaperoning

[Journal of Tissue Engineering and Regenerative Medicine] To significantly decrease the number of chondrocytes required for human elastic cartilage engineering, the authors co-cultured human mesenchymal stem cells with auricular chondrocyte to promote healthy elastic cartilage formation.

Jan Nolta receives 2022 Chancellor’s Lifetime Achievement Award in Innovation

[The University of California, Davis] UC Davis innovators in stem cells, methane reduction and education access honored with Chancellor’s Innovation Awards.

Clinical Sequencing of Soft Tissue and Bone Sarcomas Delineates Diverse Genomic Landscapes and Potential Therapeutic Targets

[Nature Communications] Scientists reported a comparative genetic analysis of 2,138 sarcomas representing 45 pathological entities. This cohort was prospectively analyzed using targeted sequencing to characterize subtype-specific somatic alterations.

Modulated Nanowire Scaffold for Highly Efficient Differentiation of Mesenchymal Stem Cells

[Journal of Nanobiotechnology] Researchers showed that a scaffold of nanowires, which are remotely actuated by a magnetic field, mechanically stimulated mesenchymal stem cells.

LncRNA RAD51-AS1 Regulates Human Bone Marrow Mesenchymal Stem Cells via Interaction with YBX1 to Ameliorate Osteoporosis

[Stem Cell Reviews and Reports] Investigators confirmed that the expression level of lncRNA RAD51-AS1 in bone marrow MSCs from patients with osteoporosis was significantly lower than those from healthy donors.

Probing Notch1-Dll4 Signaling in Regulating Osteogenic Differentiation of Human Mesenchymal Stem Cells Using Single Cell Nanobiosensor

[Scientific Reports] Scientists established a double-stranded locked nucleic acid/DNA nanobiosensor for gene expression analysis in single hMSC in both 2D and 3D microenvironments.

3D Bioprinted Alginate-Silk-Based Smart Cell-Instructive Scaffolds for Dual Differentiation of Human Mesenchymal Stem Cells

[ACS Applied Bio Materials] The authors presented this proof of concept and have demonstrated a smart design where the incorporation of phosphate groups enhanced the osteogenic differentiation, whereas the addition of silk promoted the chondrogenic differentiation.

Circ_0003204 Regulates the Osteogenic Differentiation of Human Adipose-Derived Stem Cells via miR-370-3p/HDAC4 Axis

[International Journal of Oral Science] Investigators found that circ_0003204 was significantly downregulated during osteogenic differentiation of human adipose-derived stem cells.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.