Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Micromechanical Property Mismatch between Pericellular and Extracellular Matrices Regulates Stem Cell Articular and Hypertrophic Chondrogenesis

[Matter] Researchers reported a unique biomaterial-based engineering strategy to create cartilage-tissue equivalents possessing pericellular matrix (PCM)-ECM microarchitecture of native cartilage, where human mesenchymal stem cell-laden soft microgels representing PCM were encapsulated in stiff hydrogels representing ECM.

Bone ECM-Like 3D Printing Scaffold with Liquid Crystalline and Viscoelastic Microenvironment for Bone Regeneration

[ACS Nano] Investigators developed a facile approach to fabricate a bionic scaffold perfectly combining bone ECM-like microenvironment and robust mechanical properties.

MSC Based Gene Delivery Methods and Strategies Improve the Therapeutic Efficacy of Neurological Diseases

[Bioactive Materials] Investigators focus on gene transport technologies for engineering MSCs and the application of strategies for selecting optimal delivery genes.

Postdoc Union Reaches Tentative Agreement with University of California

[Science Careers] After weeks of strikes and negotiating involving thousands of early-career researchers across the University of California (UC) system, the union representing UC postdocs and academic researchers announced it has reached a tentative agreement with administrators.

Putative Critical Quality Attribute Matrix Identifies Mesenchymal Stromal Cells with Potent Immunomodulatory and Angiogenic “Fitness” Ranges in Response to Culture Process Parameters

[Frontiers in Immunology] The authors constructed an in vitro matrix of multivariate readouts to identify putative critical quality attributes that could discriminate between specific critical processing parameters chosen for their ability to enhance MSC immunomodulatory and angiogenic potencies.

Angiopoietin-Like 3-Derivative LNA043 for Cartilage Regeneration in Osteoarthritis: A Randomized Phase I Trial

[Nature Medicine] Scientists discovered LNA043—a derivative of angiopoietin-like 3 —as a potent chondrogenesis inducer using a phenotypic screen with human mesenchymal stem cells.

Bead-Jet Printing Enabled Sparse Mesenchymal Stem Cell Patterning Augments Skeletal Muscle and Hair Follicle Regeneration

[Nature Communications] Investigators designed a “bead-jet” printer, specialized for high-throughput intra-operative formulation and printing of MSCs-laden Matrigel beads.

Impact of Repeated Intravenous Infusions of Umbilical Cord–Derived versus Bone Marrow–Derived Mesenchymal Stem Cells on Angiogenesis in a Pregnant Experimentally Induced Deep Venous Thrombosis...

[In Vitro Cellular & Developmental Biology - Animal] Researchers evaluated the impact of umbilical cord-derived MSCs and bone marrow-derived MSCs in terms of pro-angiogenic capacity and amelioration of pregnancy outcomes.

Protection of Adipose-Derived Mesenchymal Stromal Cells During Acute Lung Injury Requires Autophagy Maintained by mTOR

[Cell Death Discovery] In vitro experiments demonstrated that adipose-derived MSCs co-cultured with alveolar epithelial cells depend on autophagy for significant anti-inflammatory functions.

PROX1 Transcription Factor Controls Rhabdomyosarcoma Growth, Stemness, Myogenic Properties, and Therapeutic Targets

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrated that prospero-related homeobox 1 (PROX1) was needed for rhabdomyosarcoma cell clonogenicity, growth, and tumor formation.

Conditioned Medium of Mesenchymal Stem Cells Pretreated With H2O2 Promotes Intestinal Mucosal Repair in Acute Experimental Colitis

[Scientific Reports] MSCs were exposed to different concentrations of H2O2, and the optimal H2O2 pretreatment conditions were determined by evaluating their critical cell functional properties.

Shikonin Promotes Rat Periodontal Bone Defect Repair and Osteogenic Differentiation of BMSCs by p38 MAPK Pathway

[Odontology] Scientists explored the impact of shikonin on osteogenic differentiation of bone marrow stromal cells in vitro and further analyzed the potential mechanisms using an inhibitor of p38 MAPK

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.