Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

The authors studied the contribution of nestin+ bone marrow mesenchymal stem cells to MLL-AF9-driven acute myeloid leukemia development and chemoresistance in vivo.
[Cell Metabolism]
Forte, D., García-Fernández, M., Sánchez-Aguilera, A., Stavropoulou, V., Fielding, C., Martín-Pérez, D., López, J. A., Costa, A. S. H., Tronci, L., Nikitopoulou, E., Barber, M., Gallipoli, P., Marando, L., Castillejo, C. L. F. de, Tzankov, A., Dietmann, S., Cavo, M., Catani, L., Curti, A., … Méndez-Ferrer, S. (2020). Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metabolism, 0(0). https://doi.org/10.1016/j.cmet.2020.09.001 Cite
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Lung Mesenchymal Cells Elicit Lipid Storage in Neutrophils That Fuel Breast Cancer Lung Metastasis

In breast cancer models, scientists found that neutrophils were induced to accumulate neutral lipids upon interaction with resident mesenchymal cells in the premetastatic lung.
[Nature Immunology]
Li, P., Lu, M., Shi, J., Gong, Z., Hua, L., Li, Q., Lim, B., Zhang, X. H.-F., Chen, X., Li, S., Shultz, L. D., & Ren, G. (2020). Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0783-5 Cite
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The Use of Mesenchymal Stromal Cells in the Treatment of Coronavirus Disease 2019

The use of mesenchymal stromal cells for COVID-19 has become an attractive avenue down which almost 70 different clinical trial teams have ventured.
[Journal of Translational Medicine]
Canham, M. A., Campbell, J. D. M., & Mountford, J. C. (2020). The use of mesenchymal stromal cells in the treatment of coronavirus disease 2019. Journal of Translational Medicine, 18(1), 359. https://doi.org/10.1186/s12967-020-02532-4 Cite
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Hypoxia-Induced Downregulation of Cyclooxygenase 2 Leads to the Loss of Immunoprivilege of Allogeneic Mesenchymal Stem Cells

The authors performed in vitro and in vivo studies to elucidate the mechanisms responsible for the change in the immunophenotype of MSCs from immunoprivileged to immunogenic under ischemic conditions.
[FASEB Journal]
Sareen, N., Abu‐El‐Rub, E., Ammar, H. I., Yan, W., Sequiera, G. L., ShamsEldeen, A. M., Moudgil, M., Dhingra, R., Shokry, H. S., Rashed, L. A., Kirshenbaum, L. A., & Dhingra, S. (n.d.). Hypoxia-induced downregulation of cyclooxygenase 2 leads to the loss of immunoprivilege of allogeneic mesenchymal stem cells. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.202001478R Cite
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UK and Japan Award Eight Regenerative Medicine Projects

The Medical Research Council (MRC) and the Japan Agency for Medical Research and Development (AMED) have joined forces to support eight new Regenerative Medicine research partnerships. In this landmark collaboration, MRC and AMED will make a total of almost £7 million available to support collaborative projects that seek to advance regenerative approaches towards clinical use.
[Medical Research Council]
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Oxidative Stress-Mediated Mitochondrial Dysfunction Facilitates Mesenchymal Stem Cell Senescence in Ankylosing Spondylitis

Researchers found that ankylosing spondylitis (AS) serum facilitated senescence of MSCs in vitro, and articular tissues from AS patients exhibited higher expression levels of the cell cycle arrest-related proteins p53, p21 and p16.
[Cell Death & Disease]
Ye, G., Xie, Z., Zeng, H., Wang, P., Li, J., Zheng, G., Wang, S., Cao, Q., Li, M., Liu, W., Cen, S., Li, Z., Wu, Y., Ye, Z., & Shen, H. (2020). Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02993-x Cite
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Overexpression of Alpha-1 Antitrypsin in Mesenchymal Stromal Cells Improves their Intrinsic Biological Properties and Therapeutic Effects in Nonobese Diabetic Mice

Based on the anti‐inflammatory effects of alpha‐1 antitrypsin (AAT), scientists generated human AAT engineered MSCs by infecting human bone marrow‐derived MSCs with the pHAGE CMV‐a1aT‐UBC‐GFP‐W lentiviral vector.
[Stem Cells Translational Medicine]
Song, L., Gou, W., Wang, J., Wei, H., Lee, J., Strange, C., & Wang, H. (n.d.). Overexpression of alpha-1 antitrypsin in mesenchymal stromal cells improves their intrinsic biological properties and therapeutic effects in nonobese diabetic mice. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.20-0122 Cite
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microRNA-130b-3p Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis

A tumor xenograft mouse model was used to determine role of extracellular vesicles-microRNA-130b-3p and its target FOXO3 in lung cancer progression in vivo.
[Molecular Therapy-Oncolytics]
Guo, Q., Yan, J., Song, T., Zhong, C., Kuang, J., Mo, Y., Tan, J., Li, D., Sui, Z., Cai, K., & Zhang, J. (2020). microRNA-130b-3p Contained in Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.09.005 Cite
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Study of Sr–Ca–Si-Based Scaffolds for Bone Regeneration in Osteoporotic Models

Investigators attempted to enlarge the application range of mesenchymal stem cells with Sr incorporation in an osteoporotic bone regeneration model to evaluate whether Sr could assist in regeneration outcomes.
[International Journal of Oral Science]
Wu, Q., Wang, X., Jiang, F., Zhu, Z., Wen, J., & Jiang, X. (2020). Study of Sr–Ca–Si-based scaffolds for bone regeneration in osteoporotic models. International Journal of Oral Science, 12(1), 1–6. https://doi.org/10.1038/s41368-020-00094-1 Cite
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Thrombospondins in Bone Remodeling and Metastatic Bone Disease

The authors give an overview the involvement of TSP family members in the bone tissue microenvironment, focusing on their activity on osteoclasts and osteoblasts in bone remodeling, and present the evidence to date of their roles in bone metastasis establishment and growth.
[American Journal of Physiology-Cell Physiology]
Carminati, L., & Taraboletti, G. (2020). Thrombospondins in bone remodeling and metastatic bone disease. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00383.2020 Cite
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FDA Approves Study to Investigate the Use of Cell Therapy to Treat COVID-19 Related Multisystem Inflammatory Syndrome in Children (MIS-C)

The Cura Foundation in collaboration with The Marcus Foundation, Sanford Health and Alliance for Cell Therapy Now, is supporting a clinical trial of human cord tissue mesenchymal stromal cells to treat children with Multisystem Inflammatory Syndrome in Children.
[Alliance for Cell Therapy Now (PR Newswire Association LLC.)]
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