Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Enhancement of the Chondrogenic Differentiation Capacity of Human Dental Pulp Stem Cells via Chondroitin Sulfate-Coated Polycaprolactone-MWCNT Nanofibers

[Scientific Reports] Investigators fabricated a biocompatible fibrous and film scaffolds using electrospinning and casting techniques to induce chondrogenic differentiation for possible application in cartilaginous tissue regeneration.

Alternative Cryoprotective Agent for Corneal Stroma-Derived Mesenchymal Stromal Cells for Clinical Applications

[Scientific Reports] The human corneal stroma-derived-MSCs were cryopreserved with both compounds using a freezing rate of 1 °C/minute. The cryoprotective agents were tested by different concentrations in complete Minimum Essential Medium approved for good manufacturing practice, and a medium frequently used in cell laboratory culturing—Dulbecco’s modified eagle serum.

Mesenchymal Stem Cell-Loaded Hydrogel Improves Surgical Treatment for Chronic Cerebral Ischemia

[Translational Stroke Research] Investigators applied this hydrogel on the brain surface during encephalo-myo-synangiosis operation in rats with chronic cerebral ischemia, and evaluated its impact on cognitive performance and collateral circulation.

Tumor Microenvironment Reprogramming Improves Nanomedicine-Based Chemo-Immunotherapy in Sarcomas

[Molecular Cancer Therapeutics] Scientists tested the mechanotherapeutic ketotifen combined with either pegylated liposomal doxorubicin or pegylated liposomal coencapsulated alendronate–doxorubicin plus anti–programmed cell death protein 1 antibody in mouse models of fibrosarcoma and osteosarcoma.

Small Extracellular Vesicles Derived from microRNA-22-3p-Overexpressing Mesenchymal Stem Cells Protect Retinal Ganglion Cells by Regulating MAPK Pathway

[Communications Biology] The authors applied miR22-overexpressing MSC-small extracellular vesicles in an N-methyl-D-aspartic acid-induced retinal ganglion cell injury model to assess their short-term therapeutic effects and explore the underlying mechanisms.

Structurally and Mechanically Tuned Macroporous Hydrogels for Scalable Mesenchymal Stem Cell–Extracellular Matrix Spheroid Production

[Proceedings of The National Academy of Sciences of The United States of America] Scientists introduces a bone marrow-inspired macroporous hydrogel designed for the large-scale production of MSC–extracellular matrix spheroids.

Antitumour Effects of SFX-01 Molecule in Combination with Ionizing Radiation in Preclinical and In Vivo Models of Rhabdomyosarcoma

[BMC Cancer] RH30, RH4, RD, and JR1 cell lines as well as mouse xenograft models of rhabdomyosarcoma were used to evaluate the biological and molecular effects induced by SFX-01 treatment.

New Mechanistic Understanding of Osteoclast Differentiation and Bone Resorption Mediated by P2X7 Receptors and PI3K-Akt-GSK3β Signaling

[Cellular & Molecular Biology Letters] Osteoclasts were isolated for transcriptomic analysis, and differentially expressed genes were selected for functional enrichment analysis. Metabolite analysis was performed using liquid chromatography-tandem mass spectrometry.

New Advances of NG2-Expressing Cell Subset in Marrow Mesenchymal Stem Cells as Novel Therapeutic Tools for Liver Fibrosis/Cirrhosis

[Stem Cell Research & Therapy] Scientists compared NG2/bone marrow-MSCs (BMMSCs) with parental BMMSCs in biological and functional characteristics within a well-defined diethylnitrosamine (DEN)-induced liver fibrosis/cirrhosis injury male C57BL/6 mouse model also in a culture system.

Manufacturing Mesenchymal Stromal Cells in a Microcarrier-Microbioreactor Platform Can Enhance Cell Yield and Quality Attributes: Case Study for Acute Respiratory Distress Syndrome

[Journal of Translational Medicine] Researchers designed and implemented a microcarrier-microbioreactor approach to cell therapy manufacturing, specific to anchorage-dependent cells such as MSCs.

Targeting the PI3K/AKT/mTOR Pathway Offer a Promising Therapeutic Strategy for Cholangiocarcinoma Patients with High Doublecortin-Like Kinase 1 Expression

[Journal of Cancer Research and Clinical Oncology] The authors established doublecortin-like kinase 1 (DCLK1) knockout and DCLK1 overexpression cell lines for Colony Formation Assay and Transwell experiments to explore the tumor-promoting role of DCLK1.

Perioperative Complications of Middle Cerebral Artery Occlusion in Rats Alleviated by Human Umbilical Cord Mesenchymal Stem Cells

[Naunyn-Schmiedebergs Archives of Pharmacology] Researchers developed a model of cerebral ischemia–reperfusion injury by thrombectomy after middle cerebral artery occlusion for 90 min in rats and utilizing comprehensive multi-system evaluation methods.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.