The Cura Foundation in collaboration with The Marcus Foundation, Sanford Health and Alliance for Cell Therapy Now, is supporting a clinical trial of human cord tissue mesenchymal stromal cells to treat children with Multisystem Inflammatory Syndrome in Children.
[Alliance for Cell Therapy Now (PR Newswire Association LLC.)]
The synthesized polycaprolactone/metal ion-wollastonite scaffold was biocompatible to mouse mesenchymal stem cells and enhanced the mRNA expressionof osteoblastic specific marker genes including alkaline phosphatase and type I collagen and major transcription factor Runx2 in the presence of osteogenic medium indicates the osteoconductive nature of the scaffolds.
[Journal of Biomedical Materials Research Part B-Applied Biomaterials]
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Abudhahir, M., Saleem, A., Paramita, P., Kumar, S. D., Tze‐Wen, C., Selvamurugan, N., & Moorthi, A. (n.d.). Polycaprolactone fibrous electrospun scaffolds reinforced with copper doped wollastonite for bone tissue engineering applications. Journal of Biomedical Materials Research Part B: Applied Biomaterials, n/a(n/a). https://doi.org/10.1002/jbm.b.34729 Cite
The influence of parylene N film on the spheroid formation of osteoblast-like cells was determined and compared with that of high-hydrophilicity microenvironments. The formation of spheroids and regulation of differentiation in human mesenchymal stem cells on parylene N film was demonstrated.
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CD73-positive population from various tissues existed individually in flowcytometric pattern, especially subcutaneous fat- and amniotic-derived cells showed the highest enrichment of CD73-positive cells.
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Suto, E. G., Mabuchi, Y., Toyota, S., Taguchi, M., Naraoka, Y., Itakura, N., Matsuoka, Y., Fujii, Y., Miyasaka, N., & Akazawa, C. (2020). Advantage of fat-derived CD73 positive cells from multiple human tissues, prospective isolated mesenchymal stromal cells. Scientific Reports, 10(1), 15073. https://doi.org/10.1038/s41598-020-72012-8 Cite
Brainstorm Cell Therapeutics Inc. announced that the Japanese Patent Office has granted Brainstorm’s Japanese Patent, number: 6,753,887, titled: ‘Methods of Generating Mesenchymal Stem Cells which Secrete Neurotrophic Factors’.
[Brainstorm Cell Therapeutics Inc.]
With the capability of directly responding to the acidic microenvironment at focal areas followed by triggered release of the IL-4 plasmid-loaded liposomes within a few hours to suppress the release of inflammatory cytokines and promote neural differentiation of mesenchymal stem cells in vitro, the microenvironment-responsive immunoregulatory electrospun fibers were implanted into acute spinal cord injury rats.
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Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery | Nature Communications. (n.d.). Retrieved September 15, 2020, from https://www.nature.com/articles/s41467-020-18265-3 Cite
For the fabrication of spheroids containing endothelial tubular structures, MSCs and endothelial cells are co‐cultured with MicoCell.
Scientists characterized cell lines derived from human endometrial epithelial cells and mesenchymal cells from patients with and without endometriosis.
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Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis - ScienceDirect. (n.d.). Retrieved September 15, 2020, from https://www.sciencedirect.com/science/article/pii/S2666335X2030032X Cite
Researchers interrogated compressive force-elicited transcriptomic changes in mesenchymal stem cells purified from human periodontal ligament, and identified H3K27me3 and E2F signatures populated within upregulated and weakly downregulated genes.
[Cell Death & Disease]
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Li, Q., Sun, X., Tang, Y., Qu, Y., Zhou, Y., & Zhang, Y. (2020). EZH2 reduction is an essential mechanoresponse for the maintenance of super-enhancer polarization against compressive stress in human periodontal ligament stem cells. Cell Death & Disease, 11(9), 1–18. https://doi.org/10.1038/s41419-020-02963-3 Cite
Researchers assessed the safety and tolerability of CYP-001 (iPSC-derived MSCs), while the secondary objectives were to evaluate efficacy based on the proportion of participants who showed a complete response , overall response and overall survival by days 28/100.
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Bloor, A. J. C., Patel, A., Griffin, J. E., Gilleece, M. H., Radia, R., Yeung, D. T., Drier, D., Larson, L. S., Uenishi, G. I., Hei, D., Kelly, K., Slukvin, I., & Rasko, J. E. J. (2020). Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study. Nature Medicine, 1–6. https://doi.org/10.1038/s41591-020-1050-x Cite
Researchers highlight considerations, including whether the source of mesenchymal stem cell (MSC) isolation impacts the efficacy and safety of the therapy, in addition to assessing the feasibility of MSC topical application to the cornea and ocular surface through analysis of potential scaffolds and cell carriers for application to the eye.
[Stem Cells Translational Medicine]
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