Category Archives: Mesenchymal Cell

Mesenchymal Cell News is an online publication and email newsletter that delivers updates on the latest research in the mesenchymal stem cell field.
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Mesenchymal Cell News is a weekly email newsletter covering topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.

PIWI-Interacting RNA in Cancer: Molecular Mechanisms and Possible Clinical Implications (Review)

The authors highlight the latest research progress made in the biological functions and regulation of PIWI‑interacting RNA in mammals, their involvement in various cancer forms and their potential clinical applications.
[Oncology Reports]
Yuan, C., Qin, H., Ponnusamy, M., Chen, Y., & Lin, Z. (2021). PIWI‑interacting RNA in cancer: Molecular mechanisms and possible clinical implications (Review). Oncology Reports, 46(3), 1–16. https://doi.org/10.3892/or.2021.8160 Cite
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Compromised Dental Cells Viability Following Teeth-Whitening Exposure

Researchers assessed the viability of dental cells following time-dependent carbamide peroxide teeth-whitening treatments using an in vitro dentin perfusion assay model.
[Scientific Reports]
Redha, O., Mazinanian, M., Nguyen, S., Son, D. O., Lodyga, M., Hinz, B., Odlyha, M., McDonald, A., & Bozec, L. (2021). Compromised dental cells viability following teeth-whitening exposure. Scientific Reports, 11(1), 15547. https://doi.org/10.1038/s41598-021-94745-w Cite
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Mkx Mediates Tenogenic Differentiation but Incompletely Inhibits the Proliferation of Hypoxic MSCs

qRT-PCR, western blot, and immunofluorescence staining were performed to evaluate the expression of Mkx and other tendon-associated markers in adipose-derived MSCs and bone marrow-derived MSCs under hypoxia condition.
[Stem Cell Research & Therapy]
Chen, G., Fan, D., Zhang, W., Wang, S., Gu, J., Gao, Y., He, L., Li, W., Zhang, C., Li, M., Zhang, Y., Liu, Z., & Hao, Q. (2021). Mkx mediates tenogenic differentiation but incompletely inhibits the proliferation of hypoxic MSCs. Stem Cell Research & Therapy, 12(1), 426. https://doi.org/10.1186/s13287-021-02506-3 Cite
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FDA Gives Green Light for Multiple Sclerosis Stem Cell Trial

Non-profit research organization Hope Biosciences Stem Cell Research Foundation has received FDA authorization for a randomized, double-blind, single center, Phase II clinical trial to assess the efficacy of multiple intravenous infusions of autologous adipose-derived mesenchymal stem cells in improving symptoms and quality of life in patients with mild-to-moderate multiple sclerosis.
[Hope Biosciences Stem Cell Research Foundation (BusinessWire, Inc.)]
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PIK3R3, Part of the Regulatory Domain of PI3K, Is Upregulated in Sarcoma Stem-Like Cells and Promotes Invasion, Migration, and Chemotherapy Resistance

To identify drivers of sarcoma cancer stem-like cells, the authors compared gene expression using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma spheroids compared with the parent populations.
[Cell Death & Disease]
Yoon, C., Lu, J., Ryeom, S. W., Simon, M. C., & Yoon, S. S. (2021). PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance. Cell Death & Disease, 12(8), 1–11. https://doi.org/10.1038/s41419-021-04036-5 Cite
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FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Scientists studied proton radiotherapy (PRT) damage to skin and mesenchymal tissues of muscle and bone and found that flash PRT of the C57BL/6 murine hind leg produced fewer severe toxicities leading to death or requiring euthanasia than standard proton-PRT of the same dose.
[Cancer Research]
Velalopoulou, A., Karagounis, I. V., Cramer, G. M., Kim, M. M., Skoufos, G., Goia, D., Hagan, S., Verginadis, I. I., Shoniyozov, K., Chiango, J., Cerullo, M., Varner, K., Yao, L., Qin, L., Hatzigeorgiou, A. G., Minn, A. J., Putt, M., Lanza, M., Assenmacher, C.-A., … Busch, T. M. (2021). FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-21-1500 Cite
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Extracellular Vesicles Derived from LPS-Preconditioned Human Synovial Mesenchymal Stem Cells Inhibit Extracellular Matrix Degradation and Prevent Osteoarthritis of the Knee in a Mouse Model

Researchers explored effects of lipopolysaccharide (LPS)-pre extracellular vesicles (EVs) on chondrocyte proliferation, migration, and chondrocyte apoptosis, as well as the protective effect of LPS-pre EVs on mouse articular cartilage.
[Stem Cell Research & Therapy]
Duan, A., Shen, K., Li, B., Li, C., Zhou, H., Kong, R., Shao, Y., Qin, J., Yuan, T., Ji, J., Guo, W., Wang, X., Xue, T., Li, L., Huang, X., Sun, Y., Cai, Z., Liu, W., & Liu, F. (2021). Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model. Stem Cell Research & Therapy, 12(1), 427. https://doi.org/10.1186/s13287-021-02507-2 Cite
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The Use of Umbilical Cord-Derived Mesenchymal Stem Cells in Patients with Muscular Dystrophies: Results from Compassionate Use in Real-life Settings

The authors administered advanced therapy medicinal product containing umbilical cord-derived MSCs to 22 patients with muscular dystrophies.
[Stem Cells Translational Medicine]
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MicroRNA-26a Shuttled by Extracellular Vesicles Secreted from Adipose-Derived Mesenchymal Stem Cells Reduce Neuronal Damage through KLF9-Mediated Regulation of TRAF2/KLF2 Axis

Researchers investigated the role of miR-26a shuttled by extracellular vesicles derived from adipose-derived MSCs in neuronal damage.
[Adipocyte]
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Human Adipose-Derived Mesenchymal Stromal Cells From Face and Abdomen Undergo Replicative Senescence and Loss of Genetic Integrity After Long-term Culture

The authors evaluated long-term culture of human facial adipose-derived MSCs (fASCs) and abdominal ASCs and showed that both met the criteria for MSC characterization but presented differences in their immunophenotypic profile, and differentiation and clonogenic potentials.
[Experimental Cell Research]
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Osteogenic and Angiogenic Potency of VEGF165-Transfected Canine Bone Marrow Mesenchymal Cells Combined with Coral Hydroxyapatite in Vitro

Investigators explored the osteogenic and angiogenic potential of human vascular endothelial growth factor 165 (hVEGF165) gene-transfected canine bone marrow MSCs combined with coral hydroxyapatite scaffold.
[Tissue Engineering and Regenerative Medicine]
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