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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Ultrashort Wave Therapy Promotes the Repair of Jaw Defect by Regulating the Function of Jaw Bone Marrow Mesenchymal Stromal Cells
[Scientific Reports] Researchers evaluated the effect of ultrashort wave therapy on enhancing jaw bone marrow MSC function and promoting mandibular repair.
Mesenchymal Stromal/Stem Cells in Inflammatory Bowel Disease: Crosstalk with Innate and Adaptive Immunity
[European Journal of Pharmacology] The authors summarize the therapeutic significance of MSCs for inflammatory bowel disease in the context of their interactions with various innate and adaptive immune cells, including neutrophils, monocytes/macrophages, dendritic cells, natural killer cells, B lymphocytes, and T lymphocytes.
Intravenous Placenta-Derived Mesenchymal Stem Cells Enhance Early Survival As an Adjunct to Supportive Care in Severe Burn: A Preclinical Study
[Stem Cell Research & Therapy] Investigators proposed that placenta-derived choriodecidual MSCs may confer an additive survival benefit after severe burn injury, particularly under inadequate fluid resuscitation and thermal support.
Enhancing Pulp Regeneration through Metabolic Reprogramming of Mature Dental Pulp Stem Cells Mediated by GLUT1/HK2 mRNA Delivery
[International Journal of Oral Science] Investigators demonstrated that highly branched poly(β-amino ester)-mediated metabolic reprogramming effectively rejuvenates mature dental pulp stem cells by restoring the metabolic-ECM-angiogenesis axis.
Connexin 43-Dependent Mesenchymal Stem Cell Mitochondrial Transfer Activates PGC1α Disrupting Oxidative-Inflammation Axis in Ischemia-Reperfusion Injury
[Signal Transduction and Targeted Therapy] Researchers observed that MSCs, specifically bone marrow derived-MSCs, mitigated mitochondrial dysfunction during the early stages of ischemia-reperfusion injury-related acute kidney injury, leading to reduced inflammation, preventing cellular injury and recovery of renal function.
Extracellular Vesicle Secretome from Mesenchymal Stromal Cells Prevents Post-Ischemic Heart Failure by Targeting Cardiac Fibrosis
[Cell Stem Cell] Scientists established a clinically compliant, extracellular vesicle (EV)-enriched secretome derived from bone marrow-derived-MSCs and assessed its immunomodulatory capacity in vitro, along with its cardioprotective efficacy in blinded, placebo-controlled, and clinically relevant murine and porcine models of myocardial ischemia-reperfusion injury.
Jacksonville State Researcher Awarded More Than $73,000 Grant to Study Rare Pediatric Cancer
[Jacksonville State University] Jacksonville State University Assistant Professor of Biology Dr. Le Su has received a $73,003.37 Extended Scholar Grant from the St. Baldrick’s Childhood Cancer Research Foundation to support research centered on CIC-DUX4 sarcoma, a rare soft tissue cancer that primarily affects children and young adults.
IL-1ra Overexpression Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells in Acute Lung Injury
[International Immunopharmacology] Researchers investigated the therapeutic potential and underlying mechanisms of interleukin-1 receptor antagonist overexpressing MSCs (oeIL-1Ra-MSCs) in a murine acute lung injury model. They demonstrated that oeIL-1Ra-MSCs attenuated pulmonary pathology in murine models, reduce inflammatory responses, and mitigate alveolar epithelial cell damage.
Connexin 43-Dependent Mesenchymal Stem Cell Mitochondrial Transfer Activates PGC1α Disrupting Oxidative-Inflammation Axis in Ischemia-Reperfusion Injury
[Signal Transduction and Targeted Therapy] Scientists observed that MSCs, specifically BM-MSCs, mitigated mitochondrial dysfunction during the early stages of ischemia-reperfusion injury-related acute kidney injury, leading to reduced inflammation, preventing cellular injury and recovery of renal function.
Targeting and Antioxidant Surface-Engineered Mesenchymal Stromal Cells for Enhanced Erectile Dysfunction Therapy
[Nature Communications] Researchers showed that mesenchymal stromal cells surface-engineered with polydopamine nanoparticles conjugated to antibodies against vascular cell adhesion molecule 1 exhibit enhanced retention, survival, and therapeutic efficacy in erectile dysfunction.
Shaping Mesenchymal Stem Cell Fate with a Two-Dimensional Covalent Triazine Framework for Calmodulin Modulation
[Biomaterials] Investigators introduced a novel two-dimensional, porous, covalent triazine-based framework, CTF-Ca, synthesized under ambient conditions, that offers a new strategy for intracellular calmodulin regulation.
Mesenchymal Stem Cells Receive Adaptive Islet-Derived-miR-151-Containing sEVs to Promote β Cell Compensation in Obesity
[Science Advances] The authors showed that adaptive islet–derived small extracellular vesicles play a key role in β cell adaptation in obesity.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
