Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

UO’s Knight Campus Reveals Design of Second Science Building and New Engineering Program

[Oregon Public Broadcasting] The University of Oregon’s Knight Campus has released design details of its second science building now under construction. The sprawling facility will enable the evolution of a new bioengineering program at the unviersity.

The Role of Fibroblast Growth Factor 7 in Cartilage Development and Diseases

[Life Sciences] The authors systematically summarize the recent biological function of FGF7 and its regulatory role on chondrocytes and cartilage diseases, especially through the hot focus of two key molecules, Runx2 and Cx43.

CA Stem Cell Agency Boosts Spending amidst State Budget Deficit

[Capitol Weekly] On the table was a nearly half-billion-dollar research plan to develop revolutionary stem cell and genetic treatments for afflictions ranging from cancer to heart disease. The proposed budget boosted spending by 41 percent for 2023-24 over expenditures for the current fiscal year.

Impairment of Rigidity Sensing Caused by Mutant TP53 Gain of Function in Osteosarcoma

[Bone Research] Scientists utilized a sphere culture model, a soft agar assay, and soft and rigid hydrogel surface culture models to investigate the function of rigidity sensing in the tumorigenicity of osteosarcoma cells.

Engineering Homologous Platelet-Rich Plasma, Platelet-Rich Plasma-Derived Exosomes, and Mesenchymal Stem Cell-Derived Exosomes-Based Dual-Crosslinked Hydrogels as Bioactive Diabetic Wound Dressings

[Bioactive Materials] The authors developed novel dual-crosslinked hydrogels based on the silk proteins (SPs) sericin and fibroin, including SP@PRP, SP@MSC-Exos, and SP@PRP-Exos, to promote diabetic wound healing synergistically.

Stem Cells Therapeutic Effect in a Reserpine-Induced Fibromyalgia Rat Model: A Possible NLRP3 Inflammasome Modulation with Neurogenesis Promotion in the Cerebral Cortex

[Life Sciences] Researchers investigated the therapeutic effects of bone marrow MSCs against fibromyalgia-related cerebral cortex damage and the possible underlying mechanisms of action.

Comparison of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, and Umbilical Cord Tissue in Regeneration of a Full-Thickness Tendon Defect In Vitro...

[Biochemistry And Biophysics Reports] Researchers evaluated the potential of one marrow-, umbilical cord blood- and umbilical cord-MSC to differentiate into tendon-like cells in tensioned three-dimensional construct using gene and histological analysis.

Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Oxidative Stress-Induced Islet Impairment via the Nrf2/HO-1 Axis

[Journal Of Molecular Cell Biology] Investigators showed that intravenous injection of human umbilical cord-MSCs engrafted into the injured pancreas and promoted pancreatic β-cell function in a mouse model of type 1 diabetes mellitus.

Graphene Quantum Dots Enhance the Osteogenic Differentiation of PDLSCs in the Inflammatory Microenvironment

[BMC Oral Health] Periodontal ligament stem cells were cultured in osteogenic-induced medium with various concentrations of graphene quantum dots in standard medium or medium mimicking a proinflammatory environment.

Human Embryonic Stem Cell-Derived Mesenchymal Stem Cell Secretome Reverts Silica-Induced Airway Epithelial Cell Injury by Regulating Bmi1 Signaling

[Environmental Toxicology] Scientists investigated therapeutic effects and potential mechanism of human embryonic stem cell (hESC)-derived MSC-likes immune and matrix regulatory cells, a type of manufacturable MSCs for clinical application in silicosis mice.

A Comprehensive Review on Therapeutic Application of Mesenchymal Stem Cells in Neuroregeneration

[Life Sciences] The authors highlight the properties of various types of MSCs that are critical for peripheral nerve regeneration after nerve injury.

Rab27a-Mediated Extracellular Vesicle Secretion Contributes to Osteogenesis in Periodontal Ligament-Bone Niche Communication

[Scientific Reports] The biogenesis of extracellular vesicles from periodontal ligament stem cells was observed using scanning and transmission electron microscopy.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.