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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells through Promoting ANGPTL4 Secretion by Bone Blood Vessels
[Advanced Science] Investigators demonstrated that CGRP may contribute to bone repair in the elderly, as human CGRP levels are inversely proportional to age and proportional to bone mass in clinical data and bulk transcriptome data.
Accelerated Cartilage Regeneration via Chondrocyte Metabolic Reprogramming Using Nano-Steroid-Conjugated Mesenchymal Stem Cells in Osteoarthritis
[Theranostics] Scientists developed a novel therapeutic strategy by conjugating MSCs with steroid-loaded gold nanostars (MSC-Au-Steroid). The effects of MSC-Au-Steroid were assessed in vitro using osteoarthritis patient-derived chondrocytes and peripheral blood mononuclear cells, and in vivo using a monosodium iodoacetate-induced mouse model of osteoarthritis.
Comparative Metabolomic and Transcriptomic Analysis of 2D and 3D Mesenchymal Stem Cell Cultures for Improved Therapeutic Applications
[British Journal of Pharmacology] Researchers evaluated how 2D and 3D culture conditions affect the behaviour, proliferation, and functional properties of MSCs.
Pharmacological Inhibition of NF-κB in Mesenchymal Stromal Cells Selectively Partitions Apoptosis-Inducing Factors in Their Microvesicles and Proliferation-Inducing Factors in Their Exosomes: Implications in the...
[Cell Biology International] Researchers investigated whether NF-κB signaling pathway (NKI)-MSCs exert similar growth-inhibitory effects on leukemic cells. They found that both NKI-MSCs and their secretome induce cell cycle arrest in KG1a cells, a cell line of acute myeloid leukemia origin.
Mesenchymal Stem Cells with Pharmacological Combinations Necessary to Maximize Retinal Photoreceptor, Outer, and Inner Nuclear Layers Rescue
[Cell Biology International] Scientists evaluated MSC-mediated photoreceptor rescue and its enhancement using clinically relevant drugs: nicotinamide, vasoactive intestinal peptide, retinoic acid, or their combination.
C/EBPβ-Induced Alternative Splicing of RCAN1 Generates a Potent TCR-T Target in Mesenchymal Glioblastoma
[Cellular & Molecular Immunology] Researchers reported RCAN1-4 as a novel tumor antigen derived from alternative splicing induced by the transcription factor C/EBPβ.
Small Extracellular Vesicles from Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent β Cells and Cure Age-Related Diabetes in Mice
[Aging Cell] Human amniotic mesenchymal stem cell-derived small extracellular vesicles were identified as a novel intervention that can be used to effectively counteract cellular senescence and preserve β-cell integrity.
Single-Cell RNA Sequencing Identifies PD-L1 + Mesenchymal Stem Cells with Enhanced Immunomodulatory Capacity and Alleviated the Degree of Ectopic New Bone Formation in Ankylosing Spondylitis
[Stem Cell Research & Therapy] Scientists evaluated the immunomodulatory function of PD-L1-positive mesenchymal stem cells using scRNA-seq and investigated their roles in suppressing inflammation and regulating pathological bone formation in curdlan-induced SKG ankylosing spondylitis mouse models.
NMN-Primed Exosomes Derived from Infrapatellar Fat Pad Mesenchymal Stem Cells Exert Synergistic Anti-Inflammatory and Cartilage-Protective Effects via MERTK Pathway Activation in Knee Osteoarthritis
[International Journal of Pharmaceutics] Investigators evaluated the therapeutic potential of nicotinamide mononucleotide (NMN)–primed exosomes derived from infrapatellar fat pad MSCs, termed ExoNMN(+), under the hypothesis that NMN priming enhances their anti-inflammatory, antioxidant, and chondroprotective efficacy through MERTK-dependent signaling.
Mesenchymal Stem Cell-Derived Extracellular Vesicles in Musculoskeletal Regeneration: Mechanisms, Applications, and Future Prospects
[Stem Cell Research & Therapy] The authors summarize current knowledge on the mechanisms, therapeutic applications, engineering strategies, delivery systems, and clinical progress of the use of MSC-derived extracellar vesicles in musculoskeletal regeneration while highlighting critical obstacles and future directions for their clinical implementation.
Mesenchymal Stem Cell Based-Regenerative Therapy in Atherosclerosis: An Updated Review
[Current Cardiology Reports] Scientists provide an updated overview of MSC-based regenerative therapies in atherosclerosis. They aim to explore the mechanisms, recent advancements, and challenges associated with MSC applications in treating atherosclerosis.
Hope Biosciences Research Foundation Reports Promising Phase II Trial Results for Stem Cell Therapy in Parkinson’s Disease
[Hope Biosciences Research Foundation (Globe Newswire)] Hope Biosciences Research Foundation shares positive top-line results of a Phase II clinical trial to evaluate Hope Biosciences’ allogeneic adipose‑derived MSC for patients with early to moderate Parkinson’s Disease.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
