Mechanobiological Conditioning of Mesenchymal Stem Cells for Enhanced Vascular Regeneration

By means of high-throughput screening of the combinatorial space of mechanical-strain level and of the presence of particular kinase inhibitors, investigators showed that human mesenchymal stem cells could be mechanically and pharmacologically conditioned to enhance vascular regeneration in vivo.
[Nature Biomedical Engineering]
Lee, J., Henderson, K., Massidda, M. W., Armenta-Ochoa, M., Im, B. G., Veith, A., Lee, B.-K., Kim, M., Maceda, P., Yoon, E., Samarneh, L., Wong, M., Dunn, A. K., Kim, J., & Baker, A. B. (2021). Mechanobiological conditioning of mesenchymal stem cells for enhanced vascular regeneration. Nature Biomedical Engineering, 1–14. https://doi.org/10.1038/s41551-020-00674-w Cite
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Supervised Machine Learning for Automated Classification of Human Wharton’s Jelly Cells and Mechanosensory Hair Cells

Images from previous work, where human Wharton’s Jelly cells were differentiated into mechanosensory hair cells -like cells, were examined. Various cell features were extracted from these images, and those which were pertinent to classification were identified.
[PLoS One]
Kothapalli, A., Staecker, H., & Mellott, A. J. (2021). Supervised machine learning for automated classification of human Wharton’s Jelly cells and mechanosensory hair cells. PLOS ONE, 16(1), e0245234. https://doi.org/10.1371/journal.pone.0245234 Cite
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Comparative Proteomic Analysis of the Mesenchymal Stem Cells Secretome from Adipose, Bone Marrow, Placenta and Wharton’s Jelly

The authors characterized the protein secretome of adipose, bone marrow, placenta, and Wharton’s jelly-derived human MSCs by using conditioned media and analyzing the secretome by mass spectrometry and follow-up bioinformatics.
[International Journal of Molecular Sciences]
Shin, S., Lee, J., Kwon, Y., Park, K.-S., Jeong, J.-H., Choi, S.-J., Bang, S. I., Chang, J. W., & Lee, C. (2021). Comparative Proteomic Analysis of the Mesenchymal Stem Cells Secretome from Adipose, Bone Marrow, Placenta and Wharton’s Jelly. International Journal of Molecular Sciences, 22(2), 845. https://doi.org/10.3390/ijms22020845 Cite
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Direct Reprogramming of Epithelial Cell Rests of Malassez into Mesenchymal-Like Cells by Epigenetic Agents

Researchers examined the roles of 5-Azacytidine and valproic acid in the dedifferentiation of epithelial cell rests of Malassez into stem-like cells. Additionally, the ability of stem-like cells to differentiate into mesenchymal cells was evaluated.
[Scientific Reports]
Yoshida, K., Uehara, O., Kurashige, Y., Paudel, D., Onishi, A., Neopane, P., Hiraki, D., Morikawa, T., Harada, F., Takai, R., Sato, J., Saitoh, M., & Abiko, Y. (2021). Direct reprogramming of epithelial cell rests of malassez into mesenchymal-like cells by epigenetic agents. Scientific Reports, 11(1), 1852. https://doi.org/10.1038/s41598-020-79426-4 Cite
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Hypoxic Preconditioning of Human Umbilical Cord Mesenchymal Stem Cells Is an Effective Strategy for Treating Acute Lung Injury

When human umbilical cord MSCs were transplanted directly, only a minority of cells migrated toward damaged tissues. Moreover, their maintenance time was short, leading to unsatisfactory therapeutic results.
[Stem Cells and Development]
Wang, Y., Li, H., Li, X., Su, X., Xiao, H., & Yang, J. (2020). Hypoxic Preconditioning of Human Umbilical Cord Mesenchymal Stem Cells Is an Effective Strategy for Treating Acute Lung Injury. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0174 Cite
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Bone Therapeutics and Rigenerand Sign Partnership For Cell Therapy Process Development

Bone Therapeutics and Rigenerand SRL, the biotech company that both develops and manufactures medicinal products for cell therapy applications, primarily for regenerative medicine and oncology, announced the signing of a first agreement for a process development partnership.
[Bone Therapeutics]
Press Release
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Concomitant Control of Mechanical Properties and Degradation in Resorbable Elastomer-Like Materials Using Stereochemistry and Stoichiometry for Soft Tissue Engineering

Researchers report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone.
[Nature Communications]
Wandel, M. B., Bell, C. A., Yu, J., Arno, M. C., Dreger, N. Z., Hsu, Y.-H., Pitto-Barry, A., Worch, J. C., Dove, A. P., & Becker, M. L. (2021). Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering. Nature Communications, 12(1), 446. https://doi.org/10.1038/s41467-020-20610-5 Cite
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Energy Metabolism During Osteogenic Differentiation: The Role of Akt

Investigators tested the effect of osteogenic media containing ascorbate and β-glycerol phosphate, or various osteogenic hormones and growth factors on energy metabolism in long bone- and calvarial bone-derived osteoprogenitors.
[Stem Cells and Development]
Smith, C. O., & Eliseev, R. A. (2020). Energy Metabolism During Osteogenic Differentiation: The Role of Akt. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0141 Cite
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Impact of 3D Cell Culture on Bone Regeneration Potential of Mesenchymal Stromal Cells

The authors discuss current understanding of the effects of different 3D cell culture systems on proliferation, viability and osteogenic differentiation, as well as on the immunomodulatory and anti-inflammatory potential of MSCs.
[Stem Cell Research & Therapy]
Bicer, M., Cottrell, G. S., & Widera, D. (2021). Impact of 3D cell culture on bone regeneration potential of mesenchymal stromal cells. Stem Cell Research & Therapy, 12(1), 31. https://doi.org/10.1186/s13287-020-02094-8 Cite
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Mesenchymal Stem Cell-Derived Exosome miR-542-3p Suppresses Inflammation and Prevents Cerebral Infarction

Microarray indicated a decrease of miR-542-3p and an increase of Toll-Like Receptor 4 (TLR4) in middle cerebral artery occlusion mice comparing with sham mice. And luciferase and RIP analysis indicated a binding of miR-542-3p and TLR4.
[Current Stem Cell Research & Therapy]
Cai, G., Cai, G., Zhou, H., Zhuang, Z., Liu, K., Pei, S., Wang, Y., Wang, H., Wang, X., Xu, S., Cui, C., Sun, M., Guo, S., Jia, K., Wang, X., & Zhang, D. (2021). Mesenchymal stem cell-derived exosome miR-542-3p suppresses inflammation and prevents cerebral infarction. Stem Cell Research & Therapy, 12(1), 2. https://doi.org/10.1186/s13287-020-02030-w Cite
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Scaffold-Free Human Mesenchymal Stem Cell Construct Geometry Regulates Long Bone Regeneration

The authors hypothesized that localized presentation of transforming growth factor (TGF)-β1 and bone morphogenetic protein-2 to engineered human MSC tubes mimicking femoral diaphyses induces endochondral ossification.
[Communications Biology]
Herberg, S., Varghai, D., Alt, D. S., Dang, P. N., Park, H., Cheng, Y., Shin, J.-Y., Dikina, A. D., Boerckel, J. D., Rolle, M. W., & Alsberg, E. (2021). Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration. Communications Biology, 4(1), 1–16. https://doi.org/10.1038/s42003-020-01576-y Cite
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