The authors highlight the latest research progress made in the biological functions and regulation of PIWI‑interacting RNA in mammals, their involvement in various cancer forms and their potential clinical applications.
Researchers assessed the viability of dental cells following time-dependent carbamide peroxide teeth-whitening treatments using an in vitro dentin perfusion assay model.
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qRT-PCR, western blot, and immunofluorescence staining were performed to evaluate the expression of Mkx and other tendon-associated markers in adipose-derived MSCs and bone marrow-derived MSCs under hypoxia condition.
[Stem Cell Research & Therapy]
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Chen, G., Fan, D., Zhang, W., Wang, S., Gu, J., Gao, Y., He, L., Li, W., Zhang, C., Li, M., Zhang, Y., Liu, Z., & Hao, Q. (2021). Mkx mediates tenogenic differentiation but incompletely inhibits the proliferation of hypoxic MSCs. Stem Cell Research & Therapy, 12(1), 426. https://doi.org/10.1186/s13287-021-02506-3 Cite
Non-profit research organization Hope Biosciences Stem Cell Research Foundation has received FDA authorization for a randomized, double-blind, single center, Phase II clinical trial to assess the efficacy of multiple intravenous infusions of autologous adipose-derived mesenchymal stem cells in improving symptoms and quality of life in patients with mild-to-moderate multiple sclerosis.
[Hope Biosciences Stem Cell Research Foundation (BusinessWire, Inc.)]
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To identify drivers of sarcoma cancer stem-like cells, the authors compared gene expression using RNA sequencing between HT1080 fibrosarcoma and SK-LMS-1 leiomyosarcoma spheroids compared with the parent populations.
[Cell Death & Disease]
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Yoon, C., Lu, J., Ryeom, S. W., Simon, M. C., & Yoon, S. S. (2021). PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance. Cell Death & Disease, 12(8), 1–11. https://doi.org/10.1038/s41419-021-04036-5 Cite
Scientists studied proton radiotherapy (PRT) damage to skin and mesenchymal tissues of muscle and bone and found that flash PRT of the C57BL/6 murine hind leg produced fewer severe toxicities leading to death or requiring euthanasia than standard proton-PRT of the same dose.
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Velalopoulou, A., Karagounis, I. V., Cramer, G. M., Kim, M. M., Skoufos, G., Goia, D., Hagan, S., Verginadis, I. I., Shoniyozov, K., Chiango, J., Cerullo, M., Varner, K., Yao, L., Qin, L., Hatzigeorgiou, A. G., Minn, A. J., Putt, M., Lanza, M., Assenmacher, C.-A., … Busch, T. M. (2021). FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-21-1500 Cite
Researchers explored effects of lipopolysaccharide (LPS)-pre extracellular vesicles (EVs) on chondrocyte proliferation, migration, and chondrocyte apoptosis, as well as the protective effect of LPS-pre EVs on mouse articular cartilage.
[Stem Cell Research & Therapy]
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Duan, A., Shen, K., Li, B., Li, C., Zhou, H., Kong, R., Shao, Y., Qin, J., Yuan, T., Ji, J., Guo, W., Wang, X., Xue, T., Li, L., Huang, X., Sun, Y., Cai, Z., Liu, W., & Liu, F. (2021). Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model. Stem Cell Research & Therapy, 12(1), 427. https://doi.org/10.1186/s13287-021-02507-2 Cite
The authors administered advanced therapy medicinal product containing umbilical cord-derived MSCs to 22 patients with muscular dystrophies.
[Stem Cells Translational Medicine]
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Researchers investigated the role of miR-26a shuttled by extracellular vesicles derived from adipose-derived MSCs in neuronal damage.
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The authors evaluated long-term culture of human facial adipose-derived MSCs (fASCs) and abdominal ASCs and showed that both met the criteria for MSC characterization but presented differences in their immunophenotypic profile, and differentiation and clonogenic potentials.
[Experimental Cell Research]
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Investigators explored the osteogenic and angiogenic potential of human vascular endothelial growth factor 165 (hVEGF165) gene-transfected canine bone marrow MSCs combined with coral hydroxyapatite scaffold.
[Tissue Engineering and Regenerative Medicine]
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