Osteogenic Potential of Human Adipose Derived Stem Cells (hASCs) Seeded on Titanium Trabecular Spinal Cages

This in vitro study evaluated the adhesion, proliferation and osteogenic differentiation of adipose derived MSCs (ASCs) seeded on trabecular titanium cages. ASCs adhered, proliferated and produced an abundant extracellular matrix during the 3 weeks of culture.
[Scientific Reports]
Caliogna, L., Bina, V., Botta, L., Benazzo, F. M., Medetti, M., Maestretti, G., Mosconi, M., Cofano, F., Tartara, F., & Gastaldi, G. (2020). Osteogenic potential of human adipose derived stem cells (hASCs) seeded on titanium trabecular spinal cages. Scientific Reports, 10(1), 18284. https://doi.org/10.1038/s41598-020-75385-y Cite
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Globally Altered Epigenetic Landscape and Delayed Osteogenic Differentiation in H3.3-G34W-Mutant Giant Cell Tumor of Bone

Investigators showed that in patient-derived stromal cells, H3.3-G34W was incorporated into the chromatin and associated with massive epigenetic alterations on the DNA methylation, chromatin accessibility and histone modification level, that caould be partially recapitulated in an orthogonal cell line system by the introduction of H3.3-G34W.
[Nature Communications]
Lutsik, P., Baude, A., Mancarella, D., Öz, S., Kühn, A., Toth, R., Hey, J., Toprak, U. H., Lim, J., Nguyen, V. H., Jiang, C., Mayakonda, A., Hartmann, M., Rosemann, F., Breuer, K., Vonficht, D., Grünschläger, F., Lee, S., Schuhmacher, M. K., … Plass, C. (2020). Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone. Nature Communications, 11(1), 5414. https://doi.org/10.1038/s41467-020-18955-y Cite
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Catalent and BrainStorm Cell Therapeutics Announce Partnership for the Manufacture of Mesenchymal Stem Cell Platform Therapy NurOwn®

Catalent and BrainStorm Cell Therapeutics Inc. announced an agreement for the manufacture of NurOwn®, BrainStorm’s autologous cellular therapy being investigated for the treatment of amyotrophic lateral sclerosis. NurOwn induces MSCs to secrete high levels of neurotrophic factors known to promote the survival of neurons and neuroprotection.
[Catalent (GlobeNewswire, Inc.)]
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Emerging Players in Prostate Cancer–Bone Niche Communication

The authors highlight the emerging role of prostate cancer (PCa)-derived extracellular vesicles in reprogramming osteoblasts and support of premetastatic niche formation. They also develop the concept of cancer-associated osteoblasts and outline the potential of PCa cells to acquire an osteoblastic phenotype, termed osteomimicry, as two strategies that PCa utilizes to create a favorable protected niche.
[Trends in Cancer]
Furesi, G., Rauner, M., & Hofbauer, L. C. (2020). Emerging Players in Prostate Cancer–Bone Niche Communication. Trends in Cancer, 0(0). https://doi.org/10.1016/j.trecan.2020.09.006 Cite
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Insights Into the Use of Mesenchymal Stem Cells in COVID-19 Mediated Acute Respiratory Failure

The authors discuss key features of the current COVID-19 outbreak, and the rationale for MSC-based therapy in this setting, as well as the limitations associated with this therapeutic approach.
[NPJ Regenerative Medicine]
Durand, N., Mallea, J., & Zubair, A. C. (2020). Insights into the use of mesenchymal stem cells in COVID-19 mediated acute respiratory failure. Npj Regenerative Medicine, 5(1), 1–9. https://doi.org/10.1038/s41536-020-00105-z Cite
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Stratified Layer Analysis Reveals Intrinsic Leptin Stimulates Cryptal Mesenchymal Cells for Controlling Mucosal Inflammation

To evaluate the function of mesenchymal cells located at the large intestinal crypt, scientists established a novel method through which cells were harvested according to the histologic layers of mouse colon, and compared cellular properties between microenvironmental niches, the luminal mucosa and crypts.
[Scientific Reports]
Matsumura, S., Kurashima, Y., Murasaki, S., Morimoto, M., Arai, F., Saito, Y., Katayama, N., Kim, D., Inagaki, Y., Kudo, T., Ernst, P. B., Shimizu, T., & Kiyono, H. (2020). Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation. Scientific Reports, 10(1), 18351. https://doi.org/10.1038/s41598-020-75186-3 Cite
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Lung Gene Expression Signatures Suggest Pathogenic Links and Molecular Markers for Pulmonary Tuberculosis, Adenocarcinoma and Sarcoidosis

The authors revealed a distinct ossification-related tuberculosis (TB) lung signature, which may be associated with the activation of the BMP/SMAD/RUNX2 pathway in Mtb-infected macrophages that can restrain mycobacterial survival and promote osteogenic differentiation of mesenchymal stem cells.
[Communications Biology]
Chai, Q., Lu, Z., Liu, Z., Zhong, Y., Zhang, F., Qiu, C., Li, B., Wang, J., Zhang, L., Pang, Y., & Liu, C. H. (2020). Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis. Communications Biology, 3(1), 1–17. https://doi.org/10.1038/s42003-020-01318-0 Cite
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Ror β Expression in Activated Macrophages and Dental Pulp Stem Cells

Retinoic acid‐related orphan receptor beta (Ror β) was expressed in THP‐1 macrophages and human inflamed dental pulp stem cells during their resting stage. Upregulated expression of Ror β occurred following an anti‐inflammatory stimulus.
[International Endodontic Journal]
Gopinath, V. K., Soumya, S., & Mohammad, M. G. (n.d.). Ror β expression in Activated macrophages and Dental pulp stem cells. International Endodontic Journal, n/a(n/a). https://doi.org/10.1111/iej.13431 Cite
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Catalent and BrainStorm Cell Therapeutics Announce Partnership for the Manufacture of Mesenchymal Stem Cell Platform Therapy NurOwn®

Catalent and BrainStorm Cell Therapeutics, Inc announced an agreement for the manufacture of NurOwn®, BrainStorm’s autologous cellular therapy being investigated for the treatment of ALS, also known as Lou Gehrig’s disease or motor neuron disease.
[Catalent]
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Mesenchymal Stem Cells: a Potential Treatment Approach for Refractory Chronic Spontaneous Urticaria

Scientists found that the T cell subsets and inflammatory molecules were not affected by MSC treatment during the follow-up period. In control patients, a significant decrease was detected only at the Th2 subset, TGF-β1, PGE2, IDO and anti-FcεRI levels on the 14th day of treatment.
[Stem Cell Reviews and Reports]
Özgül Özdemir, R. B., Özdemir, A. T., Kırmaz, C., Ovalı, E., Ölmez, E., Kerem, H., Evrenos, M. K., & Deniz, G. (2020). Mesenchymal Stem Cells: a Potential Treatment Approach for Refractory Chronic Spontaneous Urticaria. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10059-w Cite
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Extracellular Matrix Plasticity as a Driver of Cell Spreading

Scientists demonstrated that network plasticity independently controls mesenchymal stem cell spreading through a biphasic relationship dependent on cell-intrinsic forces, and this relationship can be shifted by inhibiting actomyosin contractility.
[Proceedings of the National Academy of Sciences of the United States of America]
Grolman, J. M., Weinand, P., & Mooney, D. J. (2020). Extracellular matrix plasticity as a driver of cell spreading. Proceedings of the National Academy of Sciences, 117(42), 25999–26007. https://doi.org/10.1073/pnas.2008801117 Cite
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