Mesenchymal Cell News

Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.

Extracellular Vesicles from Dental Pulp Mesenchymal Stem Cells Modulate Macrophage Phenotype during Acute and Chronic Cardiac Inflammation in Athymic Nude Rats with Myocardial Infarction

[Inflammation and Regeneration] Researchers determined whether MSC-EVs could promote a pro-resolving environment in the heart by modulating macrophage populations.

lncTIMP3 Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells via miR-214/Smad4 Axis to Relieve Postmenopausal Osteoporosis

[Molecular Biology Reports] The characteristics of bone marrow MSCs isolated from the PMOP rat model were verified by flow cytometry assay, alkaline phosphatase, alizarin red and Oil Red O staining assays.

Effects of miR-29c on Proliferation and Adipogenic Differentiation of Porcine Bone Marrow Mesenchymal Stromal Cells

[Adipocyte] Researchers screened and identified 78 differently expressed miRNAs of porcine bone marrow stromal cells during adipogenic differentiation. Of which, the role of miR-29c in regulating the proliferation and adipogenic differentiation was proved and detailed.

Image-Based Discrimination of the Early Stages of Mesenchymal Stem Cell Differentiation

[Molecular Biology of The Cell] Investigators imaged nuclear structure and actin architecture using immunofluorescence and used deep learning-based computer vision technology to discriminate the early stages of MSC differentiation.

Effect of Human Bone Marrow Mesenchymal Stem Cell-Derived Microvesicles on the Apoptosis of the Multiple Myeloma Cell Line U266

[Journal of Cancer Research and Clinical Oncology] Bone marrow mesenchymal stem cell-derived microvesicles (BMSC-MVs) had an average size of ~ 410 nm. According to the MTT and LDH assays, BMSC-MV treatment reduced the U266 cell viability and mediated cytotoxic effects against them, respectively.

Enhancing Chondrogenic Differentiation of Mesenchymal Stem Cells Through Synergistic Effects of Cellulose Nanocrystals and Plastic Compression in Collagen-Based Hydrogel for Cartilage Formation

[International Journal of Biological Macromolecules] Investigators developed a hydrogel platform that incorporating cellulose nanocrystals within collagen and followed by plastic compression procedure to expel the excessive fluid out. This approach significantly improved the mechanical properties of the hydrogels and enhanced the chondrogenic differentiation of MSCs.

Enhancing Bone Regeneration and Immunomodulation via Gelatin Methacryloyl Hydrogel-Encapsulated Exosomes from Osteogenic Pre-differentiated Mesenchymal Stem Cells

[Journal of Colloid and Interface Science] Scientists extracted exosomes from osteogenically pre-differentiated human bone marrow MSCs by ultracentrifugation and encapsulated them in gelatin methacryloyl hydrogel to construct a composite scaffold.

BMSC Loaded Photo-Crosslinked Hyaluronic Acid/Collagen Hydrogel Incorporating FG4592 for Enhanced Cell Proliferation and Nucleus Pulposus Differentiation

[International Journal of Biological Macromolecules] Researchers developed a photo-crosslinkable hydrogel incorporating FG4592 to support the growth and differentiation of bone-marrow-derived MSCs.

TGF-β Signaling Regulates Differentiation of MSCs in Bone Metabolism: Disputes Among Viewpoints

[Current Stem Cell Research & Therapy] Scientists review the basics of TGF-β signaling and summarized how each of three isoforms regulates osteogenic differentiation. Three isoforms of TGF-β play distinct roles in regulating osteogenic differentiation of MSCs.

UK NIHR Invests in Trials of Advanced Therapy Medicinal Products

[MSN] The UK's National Institute for Health and Care Research (NIHR) has announced a £17.9m ($22.7m) investment in the Advanced Therapy Treatment Centre Network (ATTC Network) to enhance the UK's clinical trial infrastructure.

Beyond the Trans/Cis Binary: Introducing New Terms Will Enrich Gender Research

[Nature] We need terms such as ‘gender modality’ that are flexible enough to capture the nuances of human experience but pragmatic enough to serve science.

Curcumin-Loaded Scaffolds in Bone Regeneration

[Heliyon] Curcumin, the principal bioactive compound found in turmeric, has demonstrated notable efficacy in regulating the proliferation and differentiation of bone cells while promoting bone formation. Nevertheless, its utility is hindered by restricted water solubility and poor bioavailability.

Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.