Mesenchymal Cell News | Science News

Stromal Regulation of the Intestinal Barrier

January 27, 2023

[Mucosal Immunology] Investigators review novel findings on the emerging role of mesenchymal cells in this process using insights gained from lineage tracing approaches, Cre-based genes deletion and single cells transcriptomics.

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Diabetic Kidney Disease through the NLRP3 Signaling Pathway

January 26, 2023

[Stem Cells] Researchers co-cultured podocytes and human umbilical cord-MSCs derived exosomes (Exo) under high glucose and injected MSCs-Exo into diabetic mice, then detected the NLRP3 inflammasome both in vitro and in vivo.

Exosomes Derived from Human Amniotic Mesenchymal Stem Cells Facilitate Diabetic Wound Healing by Angiogenesis and Enrich Multiple lncRNAs

January 26, 2023

[Tissue Engineering And Regenerative Medicine] The effect of exosomes derived from human amniotic MSCs (hAMSC-Exos) on diabetic wound healing were tested by measuring wound closure rates and immunohistochemical staining of CD31.

Transfer of Mesenchymal Stem Cell Mitochondria to CD4+ T Cells Contributes to Repress Th1 Differentiation by Downregulating T-bet Expression

January 26, 2023

[Stem Cell Research & Therapy] Scientists utilized CD4+ T cells from HNT TCR transgenic mice that develop Th1-like responses upon antigenic stimulation in vitro and in vivo.

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Diabetic Kidney Disease through the NLRP3 Signaling Pathway

January 26, 2023

[Stem Cells] Researchers co-cultured podocytes and human umbilical cord-MSCs derived exosomes (Exo) under high glucose and injected MSCs-Exo into diabetic mice, then detected the NLRP3 inflammasome both in vitro and in vivo.

Exosomes Derived from Human Adipose Mesenchymal Stem Cells Ameliorate Hepatic Fibrosis by Inhibiting PI3K/Akt/mTOR Pathway and Remodeling Choline Metabolism

January 26, 2023

[Journal Of Nanobiotechnology] The authors investigated anti-fibrotic efficacy of exosomes derived from human adipose MSCs in vitro and in vivo, and identified important metabolic changes and the detailed mechanism through transcriptomic and metabolomic profiling.

Administration of Stem Cells against Cardiovascular Diseases with a Focus on Molecular Mechanisms: Current Knowledge and Prospects

January 25, 2023

[Tissue and Cell] The authors explain the application of stem cells, especially iPSCs and mesenchymal stem cells, in the treatment of cardiovascular diseases with a focus on cellular and molecular mechanisms and then discuss the advantages, disadvantages, and perspectives of using this technology in the treatment of these diseases.

Loss of RanGAP1 Drives Chromosome Instability and Rapid Tumorigenesis of Osteosarcoma

January 25, 2023

[Developmental Cell] Researchers showed that reduction and inactivation of Ran GTPase-activating protein 1 (RanGAP1) commonly occur in human osteosarcoma, which was associated with a high rate of chromothripsis.

MUC1 Promotes Cancer Stemness and Predicts Poor Prognosis in Osteosarcoma

January 25, 2023

[Pathology Research And Practice] Scientists observed elevated myxoprotein 1 (MUC1) in osteosarcoma and a depressed prognosis in patients with high MUC1 expression profiles.

Sensory Nerve Niche Regulates Mesenchymal Stem Cell Homeostasis via FGF/mTOR/Autophagy Axis

January 24, 2023

[Nature Communications] The authors showed that the sensory nerve was vital for mesenchymal tissue homeostasis and maintenance of MSCs in the continuously growing adult mouse incisor. Loss of sensory innervation leads to mesenchymal disorder and a decrease in MSCs.

Characterization of Mesenchymal Stem Cells in Pre-B Acute Lymphoblastic Leukemia

January 24, 2023

[Frontiers In Cell And Developmental Biology] Scientists investigated the cellular and transcriptome profiles of MSCs isolated from the bone marrow microenvironment of an immunocompetent BCR-ABL1+ model of B cell acute lymphoblastic leukemia.

Lymphatic Vessels in Bone Support Regeneration after Injury

January 24, 2023

[Cell] The authors found that lymphatic vessels in bone expand during genotoxic stress. VEGF-C/VEGFR-3 signaling and genotoxic stress-induced IL6 drive lymphangiogenesis in bones.