Continue reading “Immediate Intracoronary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Reduces Myocardial Injury by Regulating the Inflammatory Process via Cell-Cell Contact with T Lymphocytes”
To investigate the effects of human umbilical cord mesenchymal stem cell (HUCMSC) delivery on the acute inflammatory stage of ischemia reperfusion injury, the authors transplanted HUCMSCs or HUCMSCs with cyclosporin A via the coronary artery simultaneously during ischemia reperfusion in pigs.
[Stem Cells and Development]
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Liu, C., Kang, L.-N., Chen, F., Mu, D., Shen, S., Wang, K., Hu, J.-X., Xie, J., & Xu, B. (2020). Immediate intracoronary delivery of human umbilical cord mesenchymal stem cells reduces myocardial injury by regulating the inflammatory process via cell-cell contact with T lymphocytes. Stem Cells and Development. https://doi.org/10.1089/scd.2019.0264 Cite
The authors focus on the therapeutic potential of mesenchymal stem/stromal cells (MSCs). MSCs are available from several tissues, including bone marrow, umbilical cord, and adipose tissue.
[Seminars in Respiratory and Critical Care Medicine]
Researchers show the transplantation protocol for mesenchymal stem cells (MSCs), discuss the potential therapeutic mechanisms, and summarize clinical trials on MSCs for treating ischemic stroke.
[Journal of Neurology]
Scientists discuss the therapeutic benefit of exosomes secreted by stem and progenitor cells in preclinical models of ischemic heart disease.
Investigators employed miRNA sponges that were forcibly expressed using a lentiviral vector to knock‐down the expression of miR‐146a in human adipose‐derived stem cells.
[Journal of Tissue Engineering and Regenerative Medicine]
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Wan, S., Wu, Q., Ji, Y., Fu, X., & Wang, Y. (n.d.). Promotion of the immunomodulatory properties and osteogenic differentiation of adipose-derived mesenchymal stem cells in vitro by lentivirus-mediated miR-146a sponge expression. Journal of Tissue Engineering and Regenerative Medicine, n/a(n/a). https://doi.org/10.1002/term.3113 Cite
Researchers aimed to address the modulatory capability and associated molecular signaling of a low dosage doxycycline – a semi-synthetic tetracycline, in the functional activity of osteoblastic progenitor cells, established from a translational diabetic experimental model.
[Molecular and Cellular Endocrinology]
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Gomes, P. S., Resende, M., & Fernandes, M. H. (2020). Doxycycline restores the impaired osteogenic commitment of diabetic-derived bone marrow mesenchymal stromal cells by increasing the canonical WNT signaling. Molecular and Cellular Endocrinology, 110975. https://doi.org/10.1016/j.mce.2020.110975 Cite
Investigators showed that extracellular vesicles released by mesenchymal cells mediated microRNAtransfer to muscle stem cells.
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Sandonà, M., Consalvi, S., Tucciarone, L., De Bardi, M., Scimeca, M., Angelini, D. F., Buffa, V., D’Amico, A., Bertini, E. S., Cazzaniga, S., Bettica, P., Bouché, M., Bongiovanni, A., Puri, P. L., & Saccone, V. (2020). HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle-resident mesenchymal cells. EMBO Reports, n/a(n/a), e50863. https://doi.org/10.15252/embr.202050863 Cite
Mesenchymal stem cells, endothelial progenitor cells and c-Kit+ cardiac interstitial cells when cultured together spontaneously formed scaffold-free 3D microenvironments termed CardioClusters.
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Monsanto, M. M., Wang, B. J., Ehrenberg, Z. R., Echeagaray, O., White, K. S., Alvarez, R., Fisher, K., Sengphanith, S., Muliono, A., Gude, N. A., & Sussman, M. A. (2020). Enhancing myocardial repair with CardioClusters. Nature Communications, 11(1), 3955. https://doi.org/10.1038/s41467-020-17742-z Cite
Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
[Stem Cell Research & Therapy]
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Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020). Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 11(1), 336. https://doi.org/10.1186/s13287-020-01852-y Cite
A two-dose cohort trial allogeneic Wharton’s Jelly-derived mesenchymal stromal cells were tested in ten patients with de novo high risk or steroid refractory acute graft versus host disease post allogeneic hematopoietic stem cell transplantation.
[Stem Cell Reviews and Reports]
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Soder, R. P., Dawn, B., Weiss, M. L., Dunavin, N., Weir, S., Mitchell, J., Li, M., Shune, L., Singh, A. K., Ganguly, S., Morrison, M., Abdelhakim, H., Godwin, A. K., Abhyankar, S., & McGuirk, J. (2020). A Phase I Study to Evaluate Two Doses of Wharton’s Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10015-8 Cite
Continue reading “A Phase I Study to Evaluate Two Doses of Wharton’s Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease”
The authors systematically review literature pertaining to hematopoietic stem cell (HSC) based tissue engineering strategies in animal models of chondral repair such that trends may be identified and the utility of HSCs in chondral repair can be elucidated
67 patients were treated with Wharton’s jelly mesenchymal stem cells. The treated patients were paired with 67 reference patients from the PRO-ACT database which contains patient records from 23 amyotrophic lateral sclerosis clinical studies
[Stem Cell Reviews and Reports]
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