Investigators demonstrated that LAS1 like ribosome biogenesis factor protein expression was significantly elevated in TNBC patients, and it functionally was important for mammary tumor growth in xenograft models and enabled invasive attributes.
[Cell Death & Disease]
Weeks, S. E., Kammerud, S. C., Metge, B. J., AlSheikh, H. A., Schneider, D. A., Chen, D., Wei, S., Mobley, J. A., Ojesina, A. I., Shevde, L. A., & Samant, R. S. (2021). Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancer. Cell Death & Disease, 12(3), 1–13. https://doi.org/10.1038/s41419-021-03531-z Cite
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