Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Targeting PI3K Inhibitor Resistance in Breast Cancer with Metabolic Drugs

March 21, 2025

[Signal Transduction and Targeted Therapy] Using in vitro and orthotopic xenograft mouse models, scientists demonstrated that constitutively active mTORC1 signaling rendered PI3K inhibitor-resistant breast cancer exquisitely sensitive to various drugs targeting cancer metabolism.

MAGL Targeted PROTAC Degrader Simultaneously Enhances P53 for Synergistic Treatment of Glioblastoma Stem Cell

March 20, 2025

[Cell Death Discovery] Researchers presented a proof-of-concept PROTAC design tailored for glioblastoma (GBM) stem cells, potentially addressing the occurrence challenges for GBM.

PNO1 Enhances Ovarian Cancer Cell Growth, Invasion, and Stemness via Activating the AKT/Wnt/β-catenin Pathway

March 20, 2025

[Scientific Reports] The authors demonstrated that PNO1 silencing markedly reduced the proliferation and invasion capabilities of ovarian cancer cell lines, triggering their apoptosis.

Unraveling the Triad of Hypoxia, Cancer Cell Stemness, and Drug Resistance

March 19, 2025

[Journal of Hematology & Oncology] Investigators elucidate the interplay between hypoxia and CSCs, as well as their correlation with resistance to therapeutic drugs.

PHGDH Activation Fuels Glioblastoma Progression and Radioresistance via Serine Synthesis Pathway

March 19, 2025

[Journal of Experimental & Clinical Cancer Research] In silico analysis of glioblastoma patient data assessed serine synthesis pathway enrichment and phosphoglycerate dehydrogenase (PHGDH) expression linked with tumor stemness.

A Positive Feedback Loop of OTUD1 and C-Jun Driven by Leptin Expedites Stemness Maintenance in Ovarian Cancer

March 19, 2025

[Oncogene] The deubiquitinase OTUD1 was identified as a critical regulator of leptin in maintaining ovarian CSCs properties.

Clinical Validity of Repeated Circulating Tumor Cell Enumeration As an Early Treatment Monitoring Tool for Metastatic Breast Cancer in the PREDICT Global Pooled Analysis

March 19, 2025

[Clinical Cancer Research] Investigators confirmed clinical validity and the potential for clinical utility of serial circulating tumor cell enumeration in metastatic breast cancer patients focusing on its prognostic value in different breast cancer subtypes and clinical settings.

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Complex Genotypic-Phenotypic Relationships Altering Epithelial Composition

March 19, 2025

[Cancer Research] To identify events in ductal carcinoma in situ (DCIS) that lead to invasive cancer, scientists performed single-cell RNA-sequencing on DCIS lesions and matched normal breast tissue.

Progesterone Receptor-Dependent Downregulation of MHC Class I Promotes Tumor Immune Evasion and Growth in Breast Cancer

March 19, 2025

[Journal For Immunotherapy of Cancer] To determine the effect of progesterone receptor/progesterone on MHC class I expression, scientists treated human and mouse mammary tumor cell lines with progesterone and/or interferon and measured expression of genes involved in antigen processing and presentation, as well as surface MHC class I expression.

H3K36me2 Methyltransferase NSD2/WHSC1 Promotes Triple-Negative Breast Cancer Metastasis via Activation of ULK1-Dependent Autophagy

March 18, 2025

[Autophagy] Researchers revealed the histone methyltransferase nuclear receptor binding SET domain protein 2 (NSD2/WHSC) as a novel epigenetic regulator of autophagy in TNBC progression.

New Insights on Anti-Tumor Immunity of CD8+ T Cells: Cancer Stem Cells, Tumor Immune Microenvironment, and Immunotherapy

March 18, 2025

[Journal of Translational Medicine] Investigators review the research on the regulation of tumor development and prognosis by CSCs that directly or indirectly alter the role of tumor-infiltrating CD8+ T cells.

CCL20/CXCL5 Drives Crosstalk Between Anaplastic Thyroid Cancer Stem Cells and Tumor-Associated Macrophages to Promote Tumor Progression

March 18, 2025

[Advanced Science] Integrative analyses of single-cell RNA sequencing, cytokine/chemokine arrays, proteomics, and mRNA expression datasets were performed to reveal crosstalk between tumor-associated macrophages and anaplastic thyroid CSCs (ATCSCs) and signaling pathways in ATCSCs.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.