Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

US Patent Issued to TUCVM Researcher for Breast Cancer Research

[Tuskegee University] Tuskegee University College of Veterinary Medicine researcher Dr. Deepa Bedi was issued a US Patent for her methods for identifying aggressive breast cancer cells.

Cooperative Regulation of Coupled Oncoprotein Synthesis and Stability in Triple-Negative Breast Cancer by EGFR and CDK12/13

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Using a candidate drug screen, the authors identified that inhibition of cyclin-dependent kinases 12 and 13 (CDK12/13) dramatically sensitized diverse models of TNBC to epidermal growth factor receptor (EGFR) blockade.

Heat-Shock Protein 90α Protects NME1 against Degradation and Suppresses Metastasis of Breast Cancer

[British Journal of Cancer] Gene knockdown and overexpression were employed to examine the impact of HSP90AA1 on intracellular NME1 degradation. The motility and invasiveness of breast cancer cells were examined in vitro.

KIAA1429/VIRMA Promotes Breast Cancer Progression by m6A-Dependent Cytosolic HAS2 Stabilization

[EMBO Reports] Researchers investigated the expression of N6-methyladenosine (m6A) regulatory proteins in breast cancer. They found that expression of KIAA1429/VIRMA was upregulated in breast cancer tissue and correlated positively with poor survival.

TAZ Facilitates Breast Tumor Growth by Promoting an Immune-Suppressive Tumor Microenvironment

[Molecular Oncology] To elaborate the roles of TAZ in TNBC, the authors depleted Taz in murine TNBC 4T1 cells, using either CRISPR/Cas9 or small hairpin RNA. TAZ depletion resulted in smaller tumors compared to the tumors generated by control cells.

HER3 Functions as an Effective Therapeutic Target in Triple Negative Breast Cancer to Potentiate the Antitumor Activity of Gefitinib and Paclitaxel

[Cancer Cell International] Researchers demonstrated that increased HER3 was an effective therapeutic target for TNBC and found that their anti-HER3 monoclonal antibody could potentially enhance the efficacy of gefitinib or paclitaxel in TNBC.

A Comprehensive Analysis of the Role of QPRT in Breast Cancer

[Scientific Reports] To explore the clinical role of QPRT in breast cancer, gene expression, methylation levels and prognostic value of QPRT in breast cancer was analyzed using TCGA data.

ZNF746 Promotes M2 Macrophage Polarisation and Favours Tumor Progression in Breast Cancer via the Jagged1/Notch Pathway

[Cellular Signalling] Investigators reported that zinc finger protein 746 (ZNF746), a Krüppel-associated box and zinc finger protein, exhibited tumor-promoting properties in breast cancer.

Performance of a RAD51-Based Functional HRD Test on Paraffin-Embedded Breast Cancer Tissue

[Breast Cancer Research and Treatment] Scientists evaluated the performance of a functional RAD51-based homologous recombination deficiency (HRD) test for the identification of HRD breast cancer.

Inhibiting SETD7 Methyl-Transferase Activity Impairs Differentiation, Lipid Metabolism, and Lactogenesis in Mammary Epithelial Cells

[FEBS Letters] The impact of inhibiting SETD7 catalytic activity on mammary epithelial cell differentiation was studied by focusing on genes associated with epithelial differentiation, lactogenesis, and lipid metabolism.

Breast Cancer Organoids Derived from Patients: A Platform for Tailored Drug Screening

[Biochemical Pharmacology] Investigators deliver an overview of breast organoid culture techniques and outline future prospects for organoid modeling.

The TRIPLEX Study: Use of Patient-Derived Tumor Organoids as an Innovative Tool for Precision Medicine in Triple-Negative Breast Cancer

[BMC Cancer] The TRIPLEX study was a single-center observational study conducted to investigate the feasibility of generating patient-derived tumor organoids from triple negative breast cancer and to evaluate their ability to predict clinical response.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.