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Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
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Aminex Therapeutics Announces Multiple Sites Activated for Phase Ib/II Clinical Trial of Novel Investigational Cancer Treatment AMXT 1501 and DFMO in Patients with Solid...
[Aminex Therapeutics, Inc.] Aminex Therapeutics, Inc. announced the initiation of & first patient treated in a Phase 1b/2 clinical trial of AMXT 1501 in combination with difluoromethylornithine (DFMO) in patients with breast cancer or metastatic melanoma.
Kazia Therapeutics Reports Encouraging Preliminary Clinical Responses in Ongoing Phase Ib Study of Paxalisib in Late-Stage Metastatic Triple-Negative Breast Cancer
[Kazia Therapeutics Limited] Kazia Therapeutics provided a clinical update from its ongoing Phase 1b study evaluating paxalisib in combination with pembrolizumab and chemotherapy in patients with late-stage, Stage IV, metastatic TNBC.
Targeted Inhibition of FBXL2 Confers Susceptibility of HER2-Negative Breast Cancer to Trastuzumab Deruxtecan
[Nature Cancer] Scientists discovered that targeted inhibition of F-box protein FBXL2 elevates HER2 expression on the plasma membrane of HER2-immunohistochemistry score 0 TNBC cells, thereby sensitizing them to trastuzumab deruxtecan.
FcγRIIB Functions As an IgG Transporter in the Mammary Gland
[Proceedings of the National Academy of Sciences of the United States of America] Researchers identified FcγRIIB as the key transporter mediating maternal immunoglobulin G (IgG) transfer across the mammary gland in mammals. Using constitutive and conditional knockout mice, they demonstrated that FcγRIIB deficiency impairs mammary IgG transfer.
TGFβ Signaling Promotes Cell Cycle Progression and Resistance to the CDK4/6 Inhibitor Palbociclib through SOX4 Transcriptional Modulation in Breast Cancer Cells
[Cell Death & Disease] To dissect the temporal chromatin-based transcriptional response to transforming growth factor β (TGFβ), investigators employed 3D culture models of isogenic human breast epithelial cells, exemplified by non-oncogenic MCF-10A and their HRAS-transformed counterpart.
EZH2 Directs HER2+ Breast Cancer Progression through the Modulation of Epithelial Plasticity
[EMBO Reports] To investigate the role of enhancer of zeste homolog 2 (EZH2) in HER2+ tumor progression, scientists crossed a genetically engineered mouse model of HER2-driven breast cancer with a conditional Ezh2 knockout strain.
MAZ-Mediated Ubiquitin-Conjugating Enzyme E2C Upregulation Promotes Breast Cancer Progression via the MAPK Signaling Pathway
[Translational Oncology] Researchers demonstrated that Ubiquitin-conjugating enzyme E2C (UBE2C) is significantly upregulated in breast cancer and promotes its malignant progression.
The Role of CD26 in Breast Cancer and Its Pan-Cancer Analysis
[BMC Cancer] Investigators presented an integrative pan-cancer framework linking CD26 expression to immune infiltration, together with in vitro observations in breast cancer cells.
Molecular Pathology of Phyllodes Tumors of the Breast-Much More Than MED12
[Histopathology] Scientists summarizes the molecular pathology of phyllodes tumors, the use of these data in developing a model of phyllodes tumor pathogenesis, and how molecular pathology might be applied to aid diagnosis and treatment.
ENHERTU® Plus Pertuzumab Type II Variation Application Validated in the EU as First-Line Treatment of Patients with HER2 Positive Metastatic Breast Cancer
[Daiichi Sankyo] The European Medicines Agency has validated the Type II Variation marketing authorization application for ENHERTU® (trastuzumab deruxtecan) in combination with pertuzumab for the first-line treatment of adult patients with unresectable or metastatic HER2 positive breast cancer.
The UFL1-AKT Positive Feedback Loop Promotes Breast Cancer Progression by Enhancing Lipid Synthesis
[Nature Communications] Investigators revealed a critical role for UFMylation in lipid metabolism and identify the UFL1-AKT axis as a potential therapeutic target in breast cancer.
Crotonate Suppresses Breast Cancer Metastasis and Promotes Immunotherapy Response by Inducing ACSS2-Mediated EZH2-K348 Crotonylation
[Science Advances] Scientists presented a crotonate–crotonyl–coenzyme A–enhancer of zeste homolog 2 (EZH2) crotonylation cascade blocking breast cancer growth and metastasis.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
