ORIC Pharmaceuticals Announces Regulatory Clearance of Clinical Trial Application for ORIC-114 in Advanced Solid Tumors with EGFR or HER2 Exon 20 Alterations or HER2 Amplifications

ORIC Pharmaceuticals, Inc. announced clearance of its Clinical Trial Application by the regulatory authorities of the Republic of Korea for ORIC-114, a brain penetrant, orally bioavailable, irreversible inhibitor designed to selectively target EGFR and HER2 with high potency against exon 20 insertion mutations.
[ORIC Pharmaceuticals, Inc.]
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IKBKE Phosphorylates and Stabilizes Snail to Promote Breast Cancer Invasion and Metastasis

Researchers revealed a novel oncogenic function of IKBKE in promoting breast cancer metastasis by governing Snail abundance, and highlighted the potential of targeting IKBKE for metastatic breast cancer therapies.
[Cell Death & Differentiation]
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Flexible Etherified and Esterified Triphenylethylene Derivatives and Their Evaluation on ER Positive and Triple Negative Breast Cancer Cell Lines

Tamoxifen (TAM) is a selective estrogen receptor modulator with potential clinical benefits for all stages of breast cancer. Investigators reported novel TAM analogues that could avoid metabolism via CYP2D6.
[Chemmedchem]
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Prognostic Implications of N6-Methyladenosine RNA Regulators in Breast Cancer

Investigators used a series of bioinformatics methods and experiments to conduct exploratory research on the possible role of m6A regulators in breast cancer (BC) and revealed that YTHDF1 could serve as a new molecular marker for BC immunotherapy.
[Scientific Reports]
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SELENOF Is a New Tumor Suppressor in Breast Cancer

Restoring SELENOF could attenuate a number of aggressive cancer phenotypes in breast cancer cells, including clonogenic survival, and enhance the response to drugs or radiation used in breast cancer therapy.
[Oncogene]
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Tumor ENPP1(CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

Researchers unveiled the ectonucleotide pyrophosphatase /phosphodiesterase 1 (ENPP1)/HP axis as an unanticipated mechanism exploited by tumor cells linking inflammation to immune remodeling favoring local relapse.
[Cancer Discovery]
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Targeted Nanoparticle for Co-Delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis

A single therapeutic was developed based on trastuzumab-conjugated nanoparticles for co-delivering docetaxel and siRNA against HER2.
[Small]
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Alpha-Mangostin Activates MOAP-1 Tumor Suppressor and Mitochondrial Signaling in MCF-7 Human Breast Cancer Cells

Scientists investigated the cellular activities of α-mangostin, human cancer cells, MCF-7 and MCF-7-CR cells, by treating them with α-mangostin to measure the cellular responses, including cytotoxicity, protein-protein interaction, and protein expression.
[Evidence-Based Complementary and Alternative Medicine]
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Preparation of Modified Chitosan-Based Nanoparticles for Efficient Delivery of Doxorubicin and/or Cisplatin to Breast Cancer Cells

Investigators developed a novel pH-responsive modified chitosan-based nanoparticles system for active loading of doxorubicin and triggered intracellular release. The cytotoxic effects of these nanoparticles were performed against the MCF-7 BrCA cell line under different pHs.
[Current Cancer Drug Targets]
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Effects of Matcha Tea Extract on Cell Viability and Peroxisome Proliferator-Activated Receptor γ Expression on T47D Breast Cancer Cells

Researchers investigated the nuclear peroxisome proliferator-activated receptor gamma-dependent proliferation behavior of breast cancer cells after stimulation with matcha green tea extract.
[Archives of Gynecology and Obstetrics]
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Role of Nischarin in the Pathology of Diseases: A Special Emphasis on Breast Cancer

The authors report the prognostic value, clinical relevance, and biological significance of the Nischarin gene in breast cancer patients using the Molecular Taxonomy of Breast Cancer International Consortium and The Cancer Genome Atlas datasets.
[Oncogene]
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