Cancer Stem Cell News
Mammary Cell News
Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
Subscribe|Follow Us On
Lean Adipocyte Oxylipin Signaling Restrains Breast Cancer through Ferroptosis
[Science] Researchers combined mouse models of obesity, primary adipocyte cultures, transcriptomics, lipidomics, and patient-derived breast cancer models to define lipid-mediated mechanisms regulating breast cancer.
Allosteric Modulation of YTHDFs by Ellagic Acid Suppresses Triple-Negative Breast Cancer via Non-Canonical Activation of the HIF-1α Pathway
[Cell Reports Medicine] Through high-throughput drug screening, the authors identified ellagic acid as a compound that binds to YTHDF proteins and suppresses TNBC cell proliferation and migration in vitro and in vivo.
BCL11B Predetermines a Persister State in Breast Cancer That Is Reversed by TNFα
[Science Advances] Investigators systematically assessed the cellular differentiation status of human breast cancer cells using single-cell atlases and identified a distinct population of immature basal-like cancer cells marked by BCL11B.
RHAMM Drives Formation of Polyploid Cancer Cells and Confers Resistance to ER-Targeted Therapy in Breast Cancer
[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified RHAMM as a key driver of endocrine resistance in ER+ breast cancer by orchestrating polyploid cancer cell formation.
Bio-Inspired Albumin Platform for Synergistic Co-Delivery of Tanespimycin, Dasatinib, and Quercetin, and Enhanced Therapeutic Efficacy in Triple-Negative Breast Cancer
[Advanced Healthcare Materials] The authors fabricated biomimetic self-assembled bovine serum albumin capsules co-loaded with a new drug combination and found they were more active against TNBC cells compared to other types of breast cancer.
MED24 deficiency promotes R-loop accumulation and sensitizes to SN-38 in triple-negative breast cancer
[Cell Death & Disease] Investigators identified MED24 as a key sensitizer of SN-38, a DNA topoisomerase I inhibitor, through an epigenetic regulator focused CRISPR/Cas9 knockout screen conducted in TNBC cell lines.
Estrogen Promotes Tumor Phenotypes in ER+ and ER- Breast Cancer through UGDH-GPR3
[JCI Insight] Researchers illustrated the impact of estrogen stimulation on tumor phenotypes in ER+ and ER– cell models in vitro and in vivo. They also demonstrated UDP-glucose 6-dehydrogenase (UGDH)’s association with metastatic breast cancer via single-cell sequencing of patient specimens.
A Lipoprotein-Responsive Circular RNA, circCTCF, Couples Extracellular Lipid Availability to mTOR Signaling via ACSL5 in Triple-Negative Breast Cancer
[International Journal of Biological Macromolecules] The authors identified circCTCF, a circular RNA derived from the CTCF gene, as a lipoprotein-responsive regulator of lipid metabolism and proliferation in TNBC using an unbiased transcriptomic and circRNA profiling screen under lipoprotein-deprived conditions.
Benzophenone-3 Promotes Luminal Breast Cancer Progression via Activation of the ERα/E2F1/RPA3 Axis
[Ecotoxicology and Environmental Safety] Scientists report that Benzophenone-3 exposure potently stimulates both proliferative and migratory capacities of breast cancer cells, concomitantly accelerating the acquisition of aggressive malignant traits.
ESAM reduces sensitivity to anti-HER2 therapy in HER2-positive breast cancer by activating the mTOR pathway
[Cell Death Discovery] Researchers used transcriptome sequencing and revealed that endothelial cell adhesion molecule (ESAM) is significantly upregulated in HER2-positive breast cancer patient-derived organoids with reduced responsiveness to trastuzumab and pertuzumab.
HPV-Associated Breast Cancer: Insights Into Molecular and Epigenetic Alterations
[Cellular Signalling] The authors explore the controversial role of Human Papillomavirus (HPV) infection in breast cancer, finding evidence points toward the confirmation of genetic and epigenetic alterations induced by HPV infection in these tumors.
Pyroptosis in Triple-Negative Breast Cancer: From Inflammasome Signaling to Tumor Immune Remodeling and Translational Therapeutic Strategies
[Progress In Biophysics & Molecular Biology] Scientists critically examine pyroptosis–tumor immune microenvironment crosstalk in TNBC, prioritizing TNBC and breast cancer evidence while using non-breast cancer findings only as mechanistic comparators.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
