Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Functional Activation of the AKT-mTOR Signaling Axis in a Real-World Metastatic Breast Cancer Cohort

October 3, 2024

[British Journal of Cancer] Molecular profiles were generated by CLIA-certified laboratories from a real-world evidence cohort of 171 MBC patients. Genetic alterations of the PIK3CA pathway were measured using next-generation sequencing.

Characterization of APOBEC3B-Mediated RNA Editing in Breast Cancer Cells Reveals Regulatory Roles of NEAT1 and MALAT1 lncRNAs

October 3, 2024

[Oncogene] Researchers coupled an inducible expression cell model with a novel methodology for identifying differential variants in RNA to map A3B-mediated RNA editing sites in a breast cancer cell model.

Sacituzumab Govitecan in HR+HER2− Metastatic Breast Cancer: The Randomized Phase III EVER-132-002 Trial

October 3, 2024

[Nature Medicine] Investigators reported results of sacituzumab govitecan (SG) in Asian patients with hormone receptor-positive human epidermal growth factor receptor 2-negative (HR+HER2−) metastatic breast cancer from the EVER-132-002 study. Patients were randomized to SG or chemotherapy.

TMCO1 Is Upregulated in Breast Cancer and Regulates the Response to Pro-Apoptotic Agents in Breast Cancer Cells

October 3, 2024

[Cell Death Discovery] Scientists linked the overexpression of transmembrane and coiled-coil domains 1 (TMCO1) with prognosis in node-positive basal breast cancer patients.

UCF Medical Researchers Earn Grants for Innovative Approaches to Breast Cancer

October 3, 2024

Alicja Copik and Debbie Altomare each received $100,000 from the Florida Breast Cancer Foundation, a group focused on supporting innovative research that will create...

CCN6 Suppresses Metaplastic Breast Carcinoma by Antagonizing Wnt/β-Catenin Signaling to Inhibit EZH2-Driven EMT

October 2, 2024

[Cancer Research] Scientists showed that cellular communication network factor 6 (CCN6) interacted with the Wnt receptor FZD8 and coreceptor LRP6 on metaplastic breast carcinoma cells to antagonize Wnt-induced activation of β-catenin/TCF-mediated transcription.

Comprehensive Review of Drug-Mediated ICD Inhibition of Breast Cancer: Mechanism, Status, and Prospects

October 2, 2024

[Clinical and Experimental Medicine] The authors review the mechanism of induced immunogenic cell death (ICD) related drugs in breast cancer (BC) and provide reference for the research and development of BC treatment.

Insight into Mammary Gland Development and Tumor Progression in an E2F5 Conditional Knockout Mouse Model

October 1, 2024

[Oncogene] Testing the hypothesis that E2F5 regulated mammary function, scientists generated a mammary-specific E2F5 knockout mouse model, resulting in modest mammary gland development changes.

Claudin 7 Suppresses Invasion and Metastasis through Repression of a Smooth Muscle Actin Program

September 26, 2024

[Journal of Cell Biology] The authors used gain- and loss-of-function genetics in organoids isolated from murine breast cancer models to establish that claudin 7 suppressed invasion and metastasis.

SON Is an Essential RNA Splicing Factor Promoting ErbB2 and ErbB3 Expression in Breast Cancer

September 26, 2024

SON and ErbB expression analyses using public database, patient tissue microarray, and cell lines were performed.

Anixa Biosciences Unveils Phase II Study Plan for Breast Cancer Vaccine

September 26, 2024

Anixa Biosciences, Inc. announced its strategic plan for a Phase II study for its breast cancer vaccine. The Phase I trial is being conducted...

ZFP64 Drives Glycolysis-Mediated Stem Cell-Like Properties and Tumorigenesis in Breast Cancer

September 26, 2024

[Biology Direct] Researchers investigated whether ZFP64 regulated stem cell-like properties and tumorigenesis in breast cancer by the glycolytic pathway.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.