Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Integrating Molecular Imaging and Transcriptomic Profiling in Advanced HER2-Positive Breast Cancer Receiving Trastuzumab Emtansine (T-DM1): An Analysis of the ZEPHIR Clinical Trial

Investigators combined molecular/metabolic imaging and transcriptomic data to investigate the biological processes associated with trastuzumab and FDG uptake, and to dissect the mechanisms involved...

Novel Inhibitor against Rac1 for Therapeutic Approach in Prevention of Breast Cancer Progression

[Scientific Reports] Scientists developed peptide FGDWS as novel inhibitor targeting Rac1-Tiam1 binding site by in-silico as it was found to be the strongest interacting peptide with Rac1 at the Tiam binding site.

Second Primary Cancer Risks after Breast Cancer in BRCA1 and BRCA2 Pathogenic Variant Carriers

[Journal of Clinical Oncology] Researcehrs followed 25,811 females and 480 males diagnosed with breast cancer and tested for germline BRCA1/BRCA2 pahtogenic variants in NHS Clinical Genetics centers in England between 1995 and 2019 until second primary cancer diagnosis, death, migration, contralateral breast/ovarian surgery plus 1 year, or the 31st of December 2020.

Mitophagy: Insights into Its Signaling Molecules, Biological Functions, and Therapeutic Potential in Breast Cancer

[Cell Death Discovery] The authors highlight the expression patterns and roles of mitophagy-related signaling molecules in breast cancer progression and the potential implications of mitophagy for the development of breast cancer, aiming to provide better therapeutic strategies for breast cancer treatment.

National Breast Cancer Foundation and TelevisaUnivision Partner to Increase Breast Cancer Screening Rate Among Latinas

[National Breast Cancer Foundation, Inc.] National Breast Cancer Foundation (NBCF) and TelevisaUnivision have worked together for the past six years to empower Latinas in the U.S. with breast health education and access to early detection resources.

Alterome Therapeutics Announces First Patient Dosed in Phase 1 Study of ALTA2618 in AKT1 E17K-mutant solid tumors (AKTive-001)

[Alterome Therapeutics, Inc. (Business Wire)] Alterome Therapeutics, Inc. announced the dosing of the first patient in AKTive-001, a Phase I/Ib trial of ALTA2618 in adults with AKT1 E17K-mutant advanced solid tumors.

Breast Cancer Secretes Anti-Ferroptotic MUFAs and Depends on Selenoprotein Synthesis for Metastasis

[EMBO Molecular Medicine] Scientists showed that TNBC cells secreted an anti-ferroptotic factor in the extracellular environment when cultured at high cell densities but are primed to ferroptosis when forming colonies at low density.

Macropinocytosis Mediates Resistance to Loss of Glutamine Transport in Triple-Negative Breast Cancer

[EMBO Reports] Researchers showed that ASCT2 CRISPR knockout is tolerated by TNBC cell lines. Despite the loss of a glutamine transporter and low rate of glutamine uptake, intracellular glutamine steady-state levels were increased in ASCT2 knockout compared to control cells.

RNA Binding Protein ZCCHC24 Promotes Tumorigenicity in Triple-Negative Breast Cancer

[EMBO Reports] The authors identified the RNA-binding protein ZCCHC24 as enriched in the mesenchymal-like TNBC population. ZCCHC24 promoted the expression of a set of genes related to tumorigenicity and treatment resistance by directly binding to the cis-element “UGUWHWWA” in their mRNAs, thereby stabilizing them.

Long-Term Breast Cancer Response to CDK4/6 Inhibition Defined by TP53-Mediated Geroconversion

[Cancer Cell] Using a large, clinically annotated cohort of patients with metastatic hormone receptor-positive breast cancer, scientists identified TP53 loss and MDM2 amplification to be associated with lack of long-term disease control.

Tumor-Associated Macrophages/C-X-C Motif Chemokine Ligand 1 Promotes Breast Cancer Autophagy-Mediated Chemoresistance via IGF1R/STAT3/HMGB1 Signaling

[Cell Death & Disease] Researchers explored the molecular mechanisms by which tumor-associated macrophages/ C-X-C motif chemokine ligand 1 induced autophagy-mediated chemoresistance in breast cancer.

Tumor-Intrinsic Role of ICAM-1 in Driving Metastatic Progression of Triple-Negative Breast Cancer through Direct Interaction with EGFR

[Molecular Cancer] Scientists discovered that intercellular adhesion molecule-1 (ICAM-1) exhibited elevated expression levels in metastatic breast cancer and served as a pivotal binding adaptor for epidermal growth factor receptor (EGFR) activation, playing a crucial role in malignant progression.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.

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