Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling Pathway

[Research] Gradient rotating magnetic field exposure had a notable impact on the F-actin arrangement of MDA-MB-231, BT-549, and MDA-MB-468 cells, inhibiting cell migration and invasion.

LINC00460-FUS-MYC Feedback Loop Drives Breast Cancer Metastasis and Doxorubicin Resistance

[Oncogene] LINC00460 was demonstrated to promote stem cell-like and epithelial-mesenchymal transition characteristics in breast cancer cells.

Characterization of KIF20B as a Novel Prognostic Biomarker and Therapeutic Target for Breast Cancer

[International Journal of Oncology] Using reverse transcription‑quantitative PCR and western blotting, investigators discovered that kinesin family member 20B (KIF20B) mRNA and protein expression levels were upregulated in most breast cancer cell lines but were scarcely expressed in normal mammary epithelial cells.

Acetyl-CoA Carboxylase 1 Controls a Lipid Droplet–Peroxisome Axis and Is a Vulnerability of Endocrine-Resistant ER+ Breast Cancer

[Science Translational Medicine] Functional metabolic analysis revealed that lipid droplets together with peroxisomes, which researchers showed to be enriched and active in the long-term estrogen-deprived cells, controlled redox homeostasis and conferred metabolic adaptability to the resistant tumors.

Multiomic Profiling of Breast Cancer Cells Uncovers Stress MAPK-Associated Sensitivity to AKT Degradation

[Science Signaling] Scientists reported the development of a second-generation AKT degrader which outperformed catalytic AKT inhibition with respect to cellular suppression of AKT-dependent phenotypes in breast cancer cell lines.

Hypoxia-Activated XBP1s Recruits HDAC2-EZH2 to Engage Epigenetic Suppression of ΔNp63α Expression and Promote Breast Cancer Metastasis Independent of HIF1α

[Cell Death & Differentiation] Investigators discovered that hypoxia promoted breast cancer metastasis through suppression of ΔNp63α in a hypoxia-inducible factor 1 α (HIF1α)-independent manner.

Recent Progress of CDK4/6 Inhibitors’ Current Practice in Breast Cancer

[Cancer Gene Therapy] Researchers evaluate the utilization strategies of cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) across various subpopulations of breast cancer and explore potential therapeutic avenues following disease progression during application of CDK4/6i therapy.

BC Cancer Researchers Recognized With 2023 Canadian Cancer Society Challenge Grants

[BC Cancer Research] Congratulations to the BC Cancer researchers who are recipients of the 2023 Canadian Cancer Society Challenge Grants Competition. The grants provided through the competition support cancer research projects across the cancer continuum and across disciplines, with an ultimate goal of solving a problem in cancer that is meaningful to people affected by or at risk of cancer.

Researcher Awarded $1.5 Million to Continue Career-Long Research of Racial Disparities in Breast Cancer Outcomes

[University of Tennessee Health Science Center] Dr. White-Means received a one and a half million, four-year grant from the National Institute on Minority Health and Health Disparities to explore the intersectionality of race, residential segregation, and poverty as a driver of health disparities in breast cancer.

MicroRNA-203a Inhibits Breast Cancer Progression through the PI3K/Akt and Wnt Pathways

[Scientific Reports] Researchers investigated the microRNA-203a regulatory mechanisms and their potential functions in the progress of breast cancer.

Isocitrate Dehydrogenase 2 Regulates the Proliferation of Triple-Negative Breast Cancer through the Ferroptosis Pathway

[Scientific Reports] Through the analysis of large-throughput biological data of breast tumors, combined with the characteristics of the biological process of ferroptosis, the specific gene isocitrate dehydrogenase 2 was found to be significantly highly expressed in TNBC and functionally correlated with ferroptosis.

Estrogen-Related Receptor Alpha (ERRα) Promotes the Migration, Invasion, and Angiogenesis of Breast Cancer Stem Cell-Like Cells

[Medical Oncology] Investigators evaluated the role of estrogen-related receptor alpha in the migration, invasion and angiogenesis of breast cancer stem cells.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.