Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Breast Tumors Interfere with Endothelial TRAIL at the Premetastatic Niche to Promote Cancer Cell Seeding

[Science Advances] Investigators found that endothelial cells at the premetastatic niche coexpress tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and its cognate death receptor 5.

Oxypalmatine Regulates Proliferation and Apoptosis of Breast Cancer Cells by Inhibiting PI3K/AKT Signaling and Its Efficacy Against Breast Cancer Organoids

[Phytomedicine] Patient-derived organoid models were constructed to assess the therapeutic efficiency of Oxypalmatine in breast cancer.

Sequential Targeting of PARP with Carboplatin Inhibits Primary Tumor Growth and Distant Metastasis in Triple-Negative Breast Cancer

[British Journal of Cancer] Researchers evaluated the impact of the concurrent combination of talazoparib and carboplatin on cell survival in 13 TNBC cell lines. They compared the concurrent and sequential combination upon fork replication, migration, and invasion.

The WAVE3/β-Catenin Oncogenic Signaling Regulates Chemoresistance in Triple Negative Breast Cancer

[Breast Cancer Research] The Cancer Genome Atlas dataset was used to assess the expression of WAVE3 and β-catenin in breast cancer tumors. Kaplan–Meier Plotter analysis was used to correlate expression of WAVE3 and β-catenin with breast cancer patients’ survival probability.

A Metabolism Targeting Three-Pronged Attack Significantly Attenuates Breast Cancer Stem Cell Related Markers toward Therapeutic Application

[Biomedicine & Pharmacotherapy] To understand the role of metabolic pathways in in cancer cell survival and proliferation, investigators targeted glycolysis, pentose phosphate pathway, and mitochondria using three different inhibitors: 2-deoxyglucose, 6-aminonicotinamide, and doxycycline, separately and in combination.

Identifying Signatures of EV Secretion in Metastatic Breast Cancer through Functional Single-Cell Profiling

[iScience] Scientists developed an integrated method to identify individual cells with differences in extracellular vesicle (EV) secretion and performed linked single-cell RNA-sequencing on cloned single cells from the metastatic breast cancer cells.

LncRNA ENST00000370438 Promotes Cell Proliferation by Upregulating DHCR24 in Breast Cancer

[Molecular Carcinogenesis] Researchers performed RNA sequencing, and the results revealed an increase in the expression level of novel lncRNA ENST00000370438 in tissues of patients with breast cancer (BC). qRT-PCR results showed an increase in lncRNA ENST00000370438 expression level in 23 pairs of BC tissues.

A Novel 3D Culture Model for Human Primary Mammary Adipocytes to Study Their Metabolic Crosstalk with Breast Cancer in Lean and Obese Conditions

[Scientific Reports] The authors showed that human mammary adipocytes (M-Ads) died within 2–3 days by necrosis when grown in 2D. As an alternative, M-Ads were grown in a fibrin matrix, a 3D model that preserved their distribution, integrity, and metabolic function for up to 5 days at physiological glucose concentrations.

Anti-Inflammatory Effects of Chlorogenic Acid from Taraxacum officinale on LTA-Stimulated Bovine Mammary Epithelial Cells via the TLR2/NF-κB Pathway

[PLOS One] The chlorogenic acid content in Taraxacum officinale was determined by HPLC. Bovine mammary epithelial cells were infected with lipoteichoic acid to induce the mastitis model.

DAB2IP-Knocking Down Resulted in Radio-Resistance of Breast Cancer Cells Is Associated with Increased Hypoxia and Vasculogenic Mimicry Formation

[International Journal of Radiation Biology] Small RNA interference system was employed to decrease DOC-2/DAB2 interactive protein (DAB2IP) expression in two breast cancer cell lines, MDA-MB-231 and 4T1. Cells in response to IR or antineoplastics were detected by clone formation assay or MTT method, respectively.

Circular RNA circHMCU Promotes Breast Tumorigenesis through miR-4458/PGK1 Regulatory Cascade

[Hereditas] The expression levels of circHMCU, miR-4458, and phosphoglycerate kinase 1 (PGK1) were measured by qRT-PCR or western blot. The glucose uptake, lactate production, and ATP level were assayed by related commercial kits.

Oligometastatic Breast Cancer and Metastasis-Directed Treatment: An Aggressive Multimodal Approach to Reach the Cure

[Therapeutic Advances in Medical Oncology] The current definition of oligometastatic seems incomplete since it is based only on imaging findings and does not include biological features, and the majority of relevant data supporting this strategy comes from retrospective or non-randomized studies.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.