Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Mutational Landscape of Pure Ductal Carcinoma In Situ and Associations with Disease Prognosis and Response to Radiotherapy

July 17, 2025

[Breast Cancer Research] Through whole-exome sequencing of 147 ductal carcinoma in situ (DCIS) cases, scientists characterized the genomic landscape of pure DCIS and identified genetic alterations associated with the risk of recurrence.

DHX9-Mediated Epigenetic Silencing of BECN1 Contributes to Impaired Autophagy and Tumor Progression in Breast Cancer via Recruitment of HDAC5

July 17, 2025

[Cell Death & Disease] Scientists found that DHX9 expression is frequently elevated in breast cancer (BC) cells and tissues, which suggests poor survival. The viability and motility of BC cells are irritated by enhanced DHX9 expression.

Large-Scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

July 17, 2025

[Cancer Research] The authors generated orthotopic cell line–derived xenograft (CDX) models from breast cancer cell lines using both mammary intraductal injections and fat pad transplantations. The resulting mammary intraductal CDX and fat pad transplantation CDX models covered the full spectrum of disease progression.

Metabolic Hallmarks of Trastuzumab Resistance

July 17, 2025

[Expert Opinion on Therapeutic Targets] The authors review the metabolic strategies that HER2⁺ breast cancer cells adopt to enable trastuzumab resistance, grouping them into a structured classification that takes into account their functional nature, namely: (1) metabolic reprogramming; (2) adaptive stress response; and (3) metabolic-signaling crosstalk.

BriaCell’s Bria-IMT(TM) Demonstrates Survival Advantage over Trodelvy® and Control Group in Metastatic Breast Cancer

July 15, 2025

[BriaCell Therapeutics] BriaCell Therapeutics announced updated Phase II survival data for its lead immunotherapy candidate, Bria-IMT, in combination with an immune check point inhibitor. The data showed a meaningful survival advantage in heavily pretreated metastatic breast cancer patient subtypes.

FRMD8 Inhibits Tumor Metastasis in BRCA1-Associated TNBC by Negatively Regulating tmTNF-α

July 15, 2025

[Cellular & Molecular Biology Letters] Scientists identified that the low expression of FERM domain-containing protein 8 (FRMD8) in breast cancer type 1 susceptibility protein (BRCA1)-mutant breast cancer cells enhances the metastatic potential of tumor cells to various organs.

USP44 Promotes Chemotherapeutic Drug Resistance of Triple Negative Breast Cancer through EZH2 Protein Stability

July 15, 2025

[Cancer Biology & Therapy] Researchers identified the deubiquitinating enzyme USP44 as a contributor to chemoresistance in TNBC and investigated the potential regulatory feedback mechanisms involved.

Primary Tumor Resection Plus Systemic Therapy Versus Systemic Therapy Alone in Metastatic Breast Cancer (JCOG1017, PRIM-BC): A Randomized Clinical Trial

July 15, 2025

[British Journal of Cancer] The authors aimed to investigate whether primary tumour resection improves the survival of de novo stage IV breast cancer patients.

IL-17A-Secreting γδ T Cells Promote Resistance to CDK4/CDK6 Inhibitors in HRHER2 Breast Cancer Via CX3CR1 Macrophages

July 15, 2025

[Nature Cancer] Researchers delineated a hypoxia-sensitive, CCL2-dependent pathway recruiting IL-17A-secreting γδ T cells to mouse HR⁺HER2⁻ breast cancer.

The Vps13-Like Protein BLTP2 Regulates Phosphatidylethanolamine Levels to Maintain Plasma Membrane Fluidity and Breast Cancer Aggressiveness

July 3, 2025

[Nature Cell Biology] Scientists found that bridge-like lipid transport proteins (BLTPs) facilitated the growth of a triple-negative breast cancer cell line and sustained its aggressiveness in an in vivo model of metastasis, suggesting that maintenance of plasma membrane fluidity by BLTP2 may be critical for tumorigenesis in humans.

Autophagy-Targeted NBR1-P62/SQSTM1 Complexes Promote Breast Cancer Metastasis by Sequestering ITCH

July 3, 2025

[Nature Cell Biology] Investigators showed that autophagy normally suppresses breast cancer metastasis by enabling the clearance of NBR1–p62/SQSTM1 complexes that instruct p63-mediated pro-metastatic basal differentiation programs.

p95HER2, a Truncated Form of the HER2 Oncoprotein, Drives an Immunosuppressive Program in HER2 Breast Cancer That Limits Trastuzumab Deruxtecan Efficacy

July 3, 2025

[Nature Cancer] Researchers demonstrated that p95HER2, a truncated form of human epidermal growth factor receptor 2 (HER2), drives immune evasion in HER2-positive female breast cancer, enhancing tumor growth and conferring therapy resistance.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.