Researchers found that selective antagonists of 5-HT5A reduced the frequency of tumorsphere initiating cells residing in breast tumor cell lines and those of patient-derived xenografts that they established.
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Gwynne, W. D., Shakeel, M. S., Girgis-Gabardo, A., Kim, K. H., Ford, E., Dvorkin-Gheva, A., Aarts, C., Isaac, M., Al-awar, R., & Hassell, J. A. (2020). Antagonists of the serotonin receptor 5A target human breast tumor initiating cells. BMC Cancer, 20(1), 724. https://doi.org/10.1186/s12885-020-07193-6 Cite
Researchers evaluated the effects and mechanisms of rosmarinic acid (RA) in two racially different TNBC cell lines. Results obtained showed that RA significantly caused cytotoxic and antiproliferative effects in both cell lines in a dose- and time-dependent manner. RA induced cell cycle arrest-related apoptosis and altered the expression of many apoptosis-involved genes differently.
[European Journal of Pharmacology]
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Scientists investigated mammary epithelial cell phenotypes and metabolic profiles on animal breast extracellular matrix-derived tissue matrix gel, Col I, and Matrigel. Atomic force microscopy, fluorescence microscopy, acini formation assay, differentiation experiments, spatial migration/invasion assays, proliferation assay, and nuclear magnetic resonance spectroscopy were used to examine biological phenotypes and metabolic changes.
[Breast Cancer Research]
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Distinct phenotypes of cancer cells on tissue matrix gel | Breast Cancer Research | Full Text. (n.d.). Retrieved August 6, 2020, from https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-01321-7 Cite
Investigators found that by activating PRMT1, irradiation triggered a BRCA1-dependent program that resulted in efficient DNA repair and inhibition of apoptosis. Depletion of PRMT1 in irradiated cells resulted in a switch of BRCA1 functions from repair and survival in the nucleus to activation of cell death signals in the cytoplasm.
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PRMT1-dependent methylation of BRCA1 contributes to the epigenetic defense of breast cancer cells against ionizing radiation | Scientific Reports. (n.d.). Retrieved August 6, 2020, from https://www.nature.com/articles/s41598-020-70289-3 Cite
The nanocomplexes formed by metallodendrimers and different siRNA were examined for their zeta potential and size, and by transmission electron microscopy, fluorescence polarisation, circular dichroism, and electrophoresis. The internalisation of dendriplexes was estimated by flow cytometry and confocal microscopy in a human breast cancer cell line, following the ability of these metallodendrimers to deliver the siRNA into the cell. In vitro cell viability experiments have indicated effective interactions between Cu (II) dendrimers and pro-apoptotic siRNAs: Mcl-1 and Bcl-2 in breast cancer cells.
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Sanz del Olmo, N., Holota, M., Michlewska, S., Gómez, R., Ortega, P., Ionov, M., de la Mata, F. J., & Bryszewska, M. (2020). Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells. Pharmaceutics, 12(8), 727. https://doi.org/10.3390/pharmaceutics12080727 Cite
Daiichi Sankyo Company, Limited announced that it has entered into a global development and commercialization agreement with AstraZeneca for Daiichi Sankyo’s DS-1062, a TROP2 directed DXd antibody drug conjugate, currently in Phase I clinical development for non-small cell lung cancer and TNBC.
[Daiichi Sankyo Ltd.]
Merck announced that the FDA has accepted two new supplemental Biologics License Applications for KEYTRUDA, Merck’s anti-PD-1 therapy.
Scientists showed that AU-rich element RNA-binding protein 1 was an important inducer of the epithelial-to-mesenchymal transition process through stabilization of SNAIL1 and TWIST1 and the consequent promotion of breast cancer stem cells.
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AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1 | Oncogenesis. (n.d.). Retrieved August 6, 2020, from https://www.nature.com/articles/s41389-020-00255-1 Cite
Researchers summarized recent literature regarding molecules and pathways and reviewed the effects of cancer stem cells biology during the formation of brain metastasis in TNBC.
The authors defined the differential responses to trametinib in subpopulations of a clinically-relevant in vitro model of TNBC, and identified both adaptive and acquired elements that contribute to the emergence of drug resistance mediated by increased expression of CXCR7 and amplification of KRAS.
[Molecular Cancer Research]
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Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer | Molecular Cancer Research. (n.d.). Retrieved August 6, 2020, from https://mcr.aacrjournals.org/content/early/2020/08/04/1541-7786.MCR-19-1011 Cite
To better define the effects of oxidative stress, in vitro experiments were conducted on 4T1 and splenic mononuclear cells under hypoxic and normoxic conditions. Hydrogen peroxide was used as an reactive oxygen species source alone or in combination with hyaluronic acid.
[Journal of Cellular Physiology]
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Hyaluronic acid optimises therapeutic effects of hydrogen peroxide‐induced oxidative stress on breast cancer - Abbasi - - Journal of Cellular Physiology - Wiley Online Library. (n.d.). Retrieved August 6, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29957 Cite
Carbon dot showed selective cytotoxicity against MCF7 breast cancer cells with the IC50 of 10 μg/ml while carbon dot based silver nanoparticles demonstrated synergistic effect on cytotoxicity.
[International Journal of Biological Macromolecules]
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