Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Replication Timing Alterations Are Associated with Mutation Acquisition during Breast and Lung Cancer Evolution

[Nature Communications] Investigators assessed the impact of altered replication timing on cancer evolution by analyzing replication-timing sequencing of cancer and normal cell lines and 952 whole-genome sequenced lung and breast tumours.

MAZ-Mediated Up-Regulation of BCKDK Reprograms Glucose Metabolism and Promotes Growth by Regulating Glucose-6-Phosphate Dehydrogenase Stability in Triple-Negative Breast Cancer

[Cell Death & Disease] Researchers analyzed The Cancer Genome Atlas dataset and immunohistochemically stained surgical specimens to investigate branched-chain α-keto acid dehydrogenase kinase (BCKDK) expression and its prognostic implications in TNBC. The effects of BCKDK on tumorigenesis were assessed using cell viability, colony formation, apoptosis, and cell cycle assays, and subsequently validated in vivo.

Tumor Suppressor KEAP1 Promotes HSPA9 Degradation, Controlling Mitochondrial Biogenesis in Breast Cancer

[Cell Reports] Scientists demonstrated that kelch-like ECH-associated protein 1 (KEAP1), a positive prognostic factor, played a crucial role in regulating cell proliferation, apoptosis, and cell cycle transition in breast cancer.

Isotoosendanin Inhibits Triple-Negative Breast Cancer Metastasis by Reducing Mitochondrial Fission and Lamellipodia Formation Regulated by the Smad2/3-GOT2-MYH9 Signaling Axis

[Acta Pharmacologica Sinica] Isotoosendanin prevented MYH9-regulated mitochondrial fission and lamellipodia formation in TNBC cells by enhancing MYH9 protein degradation through a reduction in GOT2 expression, thus contributing to its inhibition of TNBC metastasis.

Breast Cancer Canada Launches $1M Fellowship to Expand Research Funding

[Breast Cancer Canada] Breast Cancer Canada announced a series of initiatives to support the progress of breast cancer research. The announcements include the introduction of a $1 million Canadian fellowship, as well as three diverse investments into breast cancer research. The grants are generously funded by AstraZeneca Canada and Breast Cancer Canada’s annual Precision Oncology Research Grants.

EMBER Creates a Unified Space for Independent Breast Cancer Transcriptomic Datasets Enabling Precision Oncology

[NPJ Breast Cancer] The authors presented an embedding approach called EMBER that created a unified space of 11,000 breast cancer transcriptomes and predicted phenotypes of transcriptomic profiles on a single sample basis.

Menin Signaling and Therapeutic Targeting in Breast Cancer

[Current Problems In Cancer] The authors review menin associated signaling pathways and gene transcription regulations, with the aim of elucidating its molecular mechanisms and of guiding the development of novel menin targeted drugs in breast cancer therapy.

CircCFL1 Promotes TNBC Stemness and Immunoescape via Deacetylation-Mediated C-myc Deubiquitylation to Facilitate Mutant TP53 Transcription

[Advanced Science] Scientists reported that circCFL1 was highly expressed in TNBC cells and tissues, and promoted the proliferation, metastasis and stemness of TNBC cells.

Resistance to FOXM1 Inhibitors in Breast Cancer Is Accompanied by Impeding Ferroptosis and Apoptotic Cell Death

[Breast Cancer Research and Treatment] In estrogen receptor-positive and TNBC cells treated with FOXM1 inhibitor NB73 and ferroptosis activators dihydroartemisinin and JKE1674, alone and in combination, the authors measured suppression of cell viability, motility, and colony formation, and monitored changes in gene and protein pathway expressions and mitochondrial integrity.

CDCA5 Accelerates Progression of Breast Cancer by Promoting the Binding of E2F1 and FOXM1

[Journal of Translational Medicine] CDCA5 was expressed at a higher level in breast cancer tissues and cell lines, and overexpression of CDCA5 was significantly associated with poor prognosis of patients with breast cancer. CDCA5 knockdown significantly suppressed the proliferation and migration, while promoted apoptosis in vitro.

ADP-Ribosylome Analysis Reveals Homogeneous DNA-Damage-Induced Serine ADP-Ribosylation across Wild-Type and BRCA-Mutant Breast Cancer Cell Lines

[Cell Reports] To understand the role of ADP-ribosylation (ADPr) in poly(ADP-ribose) polymerase 1 inhibitor (PARPi) sensitivity, scientists used liquid chromatography-tandem mass spectrometry to analyze ADPr in six breast cancer cell lines exhibiting different PARPi sensitivities.

Hinova Pharmaceuticals Receives FDA Fast Track Designation for HP518 for Treatment of AR+ Triple-Negative Breast Cancer

[Hinova Pharmaceuticals, Inc. (BioSpace)] Hinova Pharmaceuticals, Inc. announced that the US FDA has granted Fast Track designation for HP518, an investigational drug for the treatment of androgen-receptor positive TNBC.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.