Single-Cell Profiling of lncRNAs and Their Cell Lineage Commitment Roles via RNA-DNA-DNA Triplex Formation in Mammary Epithelium

Researchers used high‐throughput single‐cell RNA‐seq data to investigate the role of long non‐coding RNAs (lncRNAs) using the hierarchical model of mammary epithelium.
[Stem Cells]
Single‐cell profiling of lncRNAs and their cell lineage commitment roles via RNA‐DNA‐DNA triplex formation in mammary epithelium - Xu - - STEM CELLS - Wiley Online Library. (n.d.). Retrieved September 17, 2020, from https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.3274 Cite
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Breast Cancer Cell Detection and Characterization From Breast Milk-Derived Cells

Using the recently established culturing method that allowed propagation of normal and cancerous breast epithelial cells of luminal origin, flow cytometry characterization, and genomic sequencing, scientists showed that cancer cells were detected in breast milk.
[Cancer Research]
Bhat-Nakshatri, P., Kumar, B., Simpson, E., Ludwig, K. K., Cox, M. L., Gao, H., Liu, Y., & Nakshatri, H. (2020). Breast cancer cell detection and characterization from breast milk-derived cells. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1030 Cite
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Transcriptional Repression of p21 by EIF1AX Promotes the Proliferation of Breast Cancer Cells

A mechanistic investigation showed that EIF1AX inhibited the expression of p21, which is an essential cell cycle regulator.
[Cell Proliferation]
Li, Y., Guo, L., Ying, S., Feng, G.-H., & Zhang, Y. (n.d.). Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells. Cell Proliferation, n/a(n/a), e12903. https://doi.org/10.1111/cpr.12903 Cite
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Metastatic Status of Sentinel Lymph Nodes in Breast Cancer Determined With Photoacoustic Microscopy via Dual-Targeting Nanoparticles

Investigators report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle loaded with the near-infra-red fluorescent dye DiR-BOA for sentinel lymph nodes imaging in breast cancer.
[Light: Science & Applications]
Dai, Y., Yu, X., Wei, J., Zeng, F., Li, Y., Yang, X., Luo, Q., & Zhang, Z. (2020). Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles. Light: Science & Applications, 9(1), 164. https://doi.org/10.1038/s41377-020-00399-0 Cite
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Effect of Breast Cancer and Adjuvant Therapy on Adipose-Derived Stromal Cells: Implications for the Role of ADSCs in Regenerative Strategies for Breast Reconstruction

The authors address the effect of malignant cells, adjuvant therapies and patient-specific factors that may influence the success of regenerative strategies using adipose derived stromal cells (ADSCs) for post cancer tissue regeneration.
[Stem Cell Reviews and Reports]
Challapalli, R. S., Dwyer, R. M., McInerney, N., Kerin, M. J., & Lowery, A. J. (2020). Effect of Breast Cancer and Adjuvant Therapy on Adipose-Derived Stromal Cells: Implications for the Role of ADSCs in Regenerative Strategies for Breast Reconstruction. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10038-1 Cite
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Chronic Stress Promotes EMT-Mediated Metastasis Through Activation of STAT3 Signaling Pathway by miR-337-3p in Breast Cancer

Researchers explored the metastasis associated negative effect of chronic stress.
[Cell Death & Disease]
Du, P., Zeng, H., Xiao, Y., Zhao, Y., Zheng, B., Deng, Y., Liu, J., Huang, B., Zhang, X., Yang, K., Jiang, Y., & Ma, X. (2020). Chronic stress promotes EMT-mediated metastasis through activation of STAT3 signaling pathway by miR-337-3p in breast cancer. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02981-1 Cite
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C-Myc Regulates the Sensitivity of Breast Cancer Cells to Palbociclib via C-Myc/miR-29b-3p/CDK6 Axis

To determine potential biomarkers of palbociclib sensitivity to assist in patient selection and clinical development, scientists investigated the effects of palbociclib in a panel of molecularly characterized breast cancer cell lines.
[Cell Death & Disease]
Ji, W., Zhang, W., Wang, X., Shi, Y., Yang, F., Xie, H., Zhou, W., Wang, S., & Guan, X. (2020). c-myc regulates the sensitivity of breast cancer cells to palbociclib via c-myc/miR-29b-3p/CDK6 axis. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02980-2 Cite
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OXPHOS-Dependent Metabolic Reprogramming Prompts Metastatic Potential of Breast Cancer Cells Under Osteogenic Differentiation

Using multiple human breast cancer cell lines, the osteogenic cocktail model was established in vitro to demonstrate calcification-exacerbated metastasis.
[British Journal of Cancer]
Hu, Y., Xu, W., Zeng, H., He, Z., Lu, X., Zuo, D., Qin, G., & Chen, W. (2020). OXPHOS-dependent metabolic reprogramming prompts metastatic potential of breast cancer cells under osteogenic differentiation. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-01040-y Cite
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Tumor-Derived HMGB1 Induces CD62Ldim Neutrophil Polarization and Promotes Lung Metastasis in Triple-Negative Breast Cancer

Investigators observed that high mobility group box 1 protein (HMGB1) was highly expressed in human TNBC and positively correlated with cancer metastasis.
[Oncogenesis]
Wang, Z., Yang, C., Li, L., Jin, X., Zhang, Z., Zheng, H., Pan, J., Shi, L., Jiang, Z., Su, K., Li, B., Shao, X., Qiu, F., Yan, J., & Huang, J. (2020). Tumor-derived HMGB1 induces CD62L dim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer. Oncogenesis, 9(9), 1–17. https://doi.org/10.1038/s41389-020-00267-x Cite
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Exploring the Role of Nuclear Factor TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance and Prognosis

The authors explored the key roles of TRIP-Brs expression, modulatory effects, mutations, immune-infiltration, and prognosis in breast cancer using multidimensional approaches.
[Molecular Therapy-Oncolytics]
Mongre, R. K., Mishra, C. B., Jung, S., Lee, B. S., Quynh, N. T. N., Anh, N. H., Myagmarjav, D., Jo, T., & Lee, M.-S. (2020). Exploring the Role of Nuclear Factor TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance and Prognosis. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.09.003 Cite
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PIK3CA C-Terminal Frameshift Mutations Are Novel Oncogenic Events That Sensitize Tumors to PI3K-α Inhibition

Investigators report that PIK3CA C-terminal mutations occured at a low frequency across multiple cancer subtypes, including breast, and was sufficient to drive oncogenic transformation in vitro and in vivo.
[Proceedings of the National Academy of Sciences of the United States of America]
Spangle, J. M., Von, T., Pavlick, D. C., Khotimsky, A., Zhao, J. J., & Roberts, T. M. (2020). PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2000060117 Cite
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