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Mammary Cell News
Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
SDCBP/Syntenin-1 Stabilizes BACH1 by Disassembling the SCFFBXO22-BACH1 Complex in Triple-Negative Breast Cancer
[EMBO Journal] Scientists demonstrated that SDCBP, a tandem-PDZ-domain protein, stabilized BACH1 by disassembling the Skp1-Cullin1-FBXO22 (SCFFBXO22)-BACH1 complex via a heme/heme-oxygenase-1-independent manner in TNBC cells.
PAK5 Promotes the Trastuzumab Resistance by Increasing HER2 Nuclear Accumulation in HER2-Positive Breast Cancer
[Cell Death & Disease] Scientists showed that high expression of p21-activated kinase 5 (PAK5) was associated with HER2-targeted therapy resistance and poor outcomes of breast cancer patients.
G6PC3 Promotes Genome Maintenance and Is a Candidate Mammary Tumor Suppressor
[JCI Insight] Investigators searched for potential drivers based on germline DNA analysis from a cohort consisting of early-onset breast cancer patients negative for BRCA1/BRCA2 mutations.
SNORA47 Affects Stemness and Chemotherapy Sensitivity via EBF3/RPL11/C-Myc Axis in Luminal a Breast Cancer
[Molecular Medicine] High SNORA47 expression was linked to unfavorable survival outcomes among patients with Luminal A breast cancer in The Cancer Genome Atlas.
Development of Silver-Based Hybrid Nanoparticles Loaded with eEF2 K-siRNA and Quercetin against Triple-Negative Breast Cancer
[Drug Delivery and Translational Research] Researchers developed a novel hybrid nanoparticle using a Layer-by-Layer (method for siRNA delivery targeting eukaryotic elongation factor 2 kinase (eEF2K) in TNBC.
FOXO1 Mediates Mir-99a-5p/E2F7 to Restrain Breast Cancer Cell Proliferation and Induce Apoptosis
[BMC Cancer] Scientists clarified how FOXO1 suppressed breast cancer cell proliferation and induced apoptosis.
Hyaluronic Acid-Coated Capecitabine Nanostructures for CD44 Receptor-Mediated Targeting in Breast Cancer Therapy
[RSC Advances] Hyaluronic acid-functionalized nanomicelles provided a biocompatible and efficient system for the targeted breast cancer therapy, enhancing the therapeutic efficacy of capecitabine.
Mammary Stem Cells: Molecular Cues, Orchestrated Regulatory Mechanisms, and Its Implications in Breast Cancer
[Journal of Genetics and Genomics] The authors synthesize key progress and remaining challenges in mammary stem cells research. Molecular profiling advances have identified key markers recently, such as Procr, Dll1, Bcl11b, and PD-L1.
Trodelvy® Plus Keytruda® Demonstrates a Statistically Significant and Clinically Meaningful Improvement in Progression Free Survival in Patients With Previously Untreated PD-L1+ Metastatic Triple-Negative Breast...
[Gilead Sciences, Inc.] Gilead Sciences, Inc. announced positive topline results from the Phase III ASCENT-04/KEYNOTE-D19 study, demonstrating that Trodelvy® plus Keytruda® significantly improved progression-free survival compared to Keytruda and chemotherapy in patients with inoperable locally advanced or metastatic TNBC whose tumors express PD-L1.
Network Pharmacology, Bioinformatics Analysis, and Experimental Validation to Reveal the Target, and Pharmacological Mechanism of DHDK in Treating Breast Cancer
[Naunyn-Schmiedebergs Archives of Pharmacology] Scientists combined network pharmacology, bioinformatics, molecular docking, and experimental verification to elucidate the mechanism of action of (1E,4E)- 1,7-bis(4-hydroxyphenyl)hepta- 1,4-dien- 3-one (DHDK) in treating breast cancer.
ATF6α Inhibits ΔNp63α Expression to Promote Breast Cancer Metastasis by the GRP78-AKT1-FOXO3a Signaling
[Cell Death & Disease] Researchers demonstrated that endoplasmic reticulum stress-activated ATF6α promoted breast cancer cell migration and metastasis by downregulating the expression of ΔNp63α, a key metastasis suppressor.
Targeted Delivery of Neratinib/Xanthan Gum-Capped Calcium Carbonate Nanoparticles Induces Apoptosis through PI3K/AKT Pathway in Breast Cancer Mice Model
[International Journal of Biological Macromolecules] Investigators examined the effectiveness of neratinib-loaded xanthan gum-capped calcium carbonate nanoparticles for targeted breast cancer treatment.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
