Triple-Negative Breast Cancer Cells Rely on Kinase-Independent Functions of CDK8 to Evade NK-Cell-Mediated Tumor Surveillance

The authors used a murine model of orthotopic breast cancer to study the tumor-intrinsic role of cyclin-dependent kinase 8 (CDK8) in TNBC and linked CDK8 to programmed death-ligand 1 expression.
[Cell Death & Disease]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Immune and Nonimmune Mechanisms Mediate the Mental Stress-Induced Tumor Growth in a Xenograft Model of Breast Cancer

Scientists applied unpredictable stress stimuli to breast tumor-bearing mice and established a xenograft model of breast cancer that suffered mental stress. This was followed by behavioral tests, tumor growth tracking, immune analysis, miRNA screening, and tumor cell proliferation analysis.
[Cell Death & Disease]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Breast Cancer Dormancy Is Associated with a 4NG1 State and Not Senescence

Investigators thoroughly characterized the dormant D2.OR and ZR-75-1, and proliferative D2A1 breast cancer cell line models in vivo and in vitro, and assessed if there was overlap between a dormant and a senescent phenotype.
[npj Breast Cancer]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

NRIP1 Is Activated by C-JUN/C-FOS and Activates the Expression of PGR, ESR1 and CCND1 in Luminal a Breast Cancer

Researchers identified differentially expressed genes via a comparison between luminal A breast cancer subtypes and normal mammary ductal cells from healthy donors.
[Scientific Reports]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Combinative Treatment of Curdione and Docetaxel Triggers Reactive Oxygen Species (ROS)-Mediated Intrinsic Apoptosis of Triple-Negative Breast Cancer Cells

Scientists reported that the combination of curdione and docetaxel (DTX) strengthened the DTX-induced pro-apoptotic effects in TNBC cells and identified its involved signaling pathways.
[Bioengineered]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Single-Cell Transcriptomics Reveal the Heterogeneity and Dynamic of Cancer Stem-Like Cells during Breast Tumor Progression

The authors used the breast cancer mouse model MMTV-PyMT, and constructed a single-cell atlas of 31,778 cells from four distinct stages of tumor progression, during which malignant transition occured.
[Cell Death & Disease]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Dual Recombinase Action in the Normal and Neoplastic Mammary Gland Epithelium

Researchers demonstrated the versatile applicability of the new MMTV-Flp strain and manipulated genes in a temporally and spatially controlled manner in the normal mammary gland, in luminal-type mammary tumors that overexpressed ERBB2, and in a new KRAS-associated mammary cancer model.
[Scientific Reports]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

The Pro-Proliferative Effect of Interferon-γ in Breast Cancer Cell Lines Is Dependent on Stimulation of ASCT2-Mediated Glutamine Cellular Uptake

Scientists reported that IFN-γ and insulin possessed pro-proliferative effects in breast cancer and non-cancer cell lines, respectively, which were dependent on increased ASCT2-mediated glutamine transport.
[Life Sciences]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Prolactin and Endocrine Therapy Resistance in Breast Cancer: The Next Potential Hope for Breast Cancer Treatment

Scientists illustrated and summarized the correlations between endocrine therapy resistance in breast cancer and prolactin (PRL), as well as the pathophysiological mechanisms and clinical practices.
[Journal of Cellular and Molecular Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Light at Night and Risk of Breast Cancer: A Systematic Review and Dose–Response Meta-Analysis

Investigators perform a systematic review of epidemiological evidence on the association between LAN exposure and breast cancer risk, using a dose–response meta-analysis and examining the shape of the relation.
[International Journal of Health Geographics]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Celcuity Announces Clinical Trial Collaboration with University of Rochester Wilmot Cancer Center and Puma to Study Patients with Breast Cancer Brain Metastases

Celcuity, Inc. announced a clinical trial collaboration with the University of Rochester Wilmot Cancer Center and Puma Biotechnology to conduct a Phase II clinical trial that will evaluate the efficacy and safety of NERLYNX®, and Xeloda®.
[Celcuity, Inc. (BusinessWire, Inc.)]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share
Share