Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

3D Culture Modeling of Metastatic Breast Cancer Cells in Additive Manufactured Scaffolds

[ACS Applied Materials & interfaces] Scientists used porous 3D scaffolds, designed with two different porosities along with 2D tissue culture polystyrene plates were used with a model breast cancer human cell line.

Susan G. Komen® Invests $21.7 Million In Research Focused on Improving Outcomes For Breast Cancer Patients

[Susan G. Komen®] Susan G. Komen® has awarded $21.7 million to fund 48 new research projects at 26 distinguished academic medical institutions in the US that are focused on improving patient outcomes – particularly for people with the most aggressive breast cancers, or who have experienced a recurrence or metastasis.

DNA Minicircle as a Novel STAT3 Decoy Oligodeoxynucleotide Endowed with Anticancer Activity in Triple Negative Breast Cancer

[Molecular Therapy-Nucleic Acids] Investigators described the in vitro and in vivo activity of formulated 95 bp minicircles bearing one or several STAT3 binding sequences in TNBC.

Combined Inhibition of EZH2 and ATM Is Synthetic Lethal in BRCA1-Deficient Breast Cancer

[Breast Cancer Research] To validate the role of EZH2 as a therapeutic target and to identify new synergistic drug combinations, scientists performed a high-throughput drug combination screen in various cell lines derived from BRCA1-deficient and -proficient mouse mammary tumors.

Cryptolepine Suppresses Breast Adenocarcinoma via Inhibition of HIF-1 Mediated Glycolysis

[Biomedicine & Pharmacotherapy] Researchers revealed that cryptolepine could effectively suppress the process of hypoxia inducible factor-1 α(HIF-1α) mRNA translation rather than transcription.

Long Noncoding RNA ST8SIA6-AS1 Promotes Cell Proliferation and Metastasis in Triple-Negative Breast Cancer by Targeting miR-145-5p/CDCA3 to Inactivate the p53/p21 Signaling Pathway

[Environmental Toxicology] ST8SIA6-AS1 displayed a higher expression in TNBC cells. Silencing ST8SIA6-AS1 impaired cell proliferation, cell cycle progression, migration, and invasion in vitro, and slowed tumor growth in vivo.

MORC2/β-Catenin Signaling Axis Promotes Proliferation and Migration of Breast Cancer Cells

[Medical Oncology] The authors reported that the chromatin remodeler microrchidia 2 (MORC2) expression positively correlated with β-catenin expression in breast cancer cell lines and patients.

Targeting LIPA Independent of Its Lipase Activity Is a Therapeutic Strategy in Solid Tumors via Induction of Endoplasmic Reticulum Stress

[Nature Cancer] Investigators defined lysosomal acid lipase A (LIPA) as a viable molecular target in TNBC and identified a stereospecific small molecule that binds LIPA.

Recent Insights into the Effects of Metabolism on Breast Cancer Cell Dormancy

[British Journal of Cancer] The authors highlight that the metabolic states/shifts of dormant breast cancer cells seem to be dependent on different BC subtypes and receptor status; however, more work needs to be done to fully map these differences.

Phenazine Derivatives Attenuate the Stemness of Breast Cancer Cells through Triggering Ferroptosis

[Cellular and Molecular Life Sciences] Scientists focused on the compounds without affecting cell viability and screened out three potential compounds that could significantly attenuate the stemness of breast cancer cells, as evident by the decrease of stemness marker expression.

Breast Cancer Cells Mediate Endothelial Cell Activation, Promoting Von Willebrand Factor Release, Tumour Adhesion and Transendothelial Migration

[Journal of Thrombosis and Haemostasis] Researchers highlighted the significant crosstalk between tumor cells and the endothelium including increased von Willebrand Factor secretion which may have contributed to tumor metastasis.

$250,000 Grant to Dr. Paola Marignani to Identify HER2+ Markers

[The Breast Cancer Society of Canada] The Breast Cancer Society of Canada has announced $250,000 in funding to the Department of Biochemistry and Molecular Biology, Faculty of Medicine at Dalhousie University, for a research project led by Dr. Paola Marignani.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.