Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Fusion of Tumor Cells with Lipid-Associated Macrophages Drives Metastatic Progression of Breast Cancer

December 4, 2025

[Cancer Research] Using single-cell transcriptomic analysis and in situ profiling of primary tumors, metastases, and circulating tumor cells from multiple patients with breast cancer, investigators' identified a unique EPCAM⁺ CD68⁺ TREM2⁺ tumor subpopulation.

C/EBPβ Stabilizes Oxidative Stress in Triple-Negative Breast Cancer Cells, Driving Taxane Resistance, and Immune Evasion

December 4, 2025

[Molecular Therapy] Scientists developed an aptamer-siRNA conjugate containing a transferrin receptor 1 aptamer linked to a CCAAT/enhancer-binding protein beta (C/EBPβ) siRNA.

Cadherin-1-Mediated Communication at the Leader-Follower Boundary Controls Mouse Breast Tumor Organoid Collective Migration

December 4, 2025

[Cell Reports] Through 3D computational simulations and live video 3D imaging of primary mouse breast tumor organoids in a microfluidic device, researchers investigated the roles of type I cadherins during collective migration.

TRIM25 Degrades BRD7 Protein Stability through the Ubiquitin Proteasome Pathway to Promote Breast Cancer Progression and Paclitaxel Resistance by Activating YB1/Bcl-2 Transcription Axis

December 4, 2025

[Cell Death & Disease] Investigators revealed that TRIM25 effectively promoted cell proliferation, cell cycle progression, and paclitaxel chemoresistance of breast cancer cells.

EGFR Amplification and PI3K Pathway Mutations Identify a Subset of Breast Cancers That Synergistically Respond to EGFR and PI3K Inhibition

December 4, 2025

[Oncogene] The authors presented evidence of a patient subset with EGFR amplification and PI3Kinase pathway mutations in breast cancer which can be synergistically targeted by dual EGFR/PI3K inhibition.

Functional and Clinical Significance of the RNA m6a Methyltransferase Complex in Breast Cancer

December 4, 2025

[npj Breast Cancer] Utilizing a large breast cancer cohort, scientists identified that increased METTL14 and CBLL1 expression was associated with a more favorable prognosis, whereas increased METTL3 expression was associated with poorer patient outcomes in TNBC.

Germline Variants of the POLH and RAD51 Genes Are Candidate Variants Associated with Risk of Hormone Receptor-Negative Young-Onset Breast Cancer

December 4, 2025

[npj Breast Cancer] To uncover novel cancer susceptibility genes, researchers performed germline whole-exome/genome sequencing of samples from 564 patients with young-onset breast cancer, as well as samples from 4032 female controls.

BRCA1: An Unrecognized Modulator of Lineage Plasticity in Basal-like Breast Cancer

December 4, 2025

[Journal of Mammary Gland Biology and Neoplasia] The authors shed light on the role of BRCA1 in lineage plasticity and highlights probable mechanisms by which BRCA1 could promote this lineage plasticity.

KDA Group Announces Partnership Agreement with Chu De Québec– Université Laval for the Deployment of Medherize

December 4, 2025

[KDA Group] KDA Group Inc. announced the signing of a partnership and collaboration agreement with the Centre hospitalier universitaire de Québec, Université Laval for the deployment of its Medherize platform at Hôpital du Saint-Sacrement.

Landscape of Gene Fusions in Hormone Receptor-Positive Breast Cancer Reveals ADK Fusions As Drivers of Progression and Potential Therapeutic Targets

November 20, 2025

[Cell Discovery] Researchers leveraged a large-scale multiomics cohort and a drug screening platform for breast cancer to systematically profile gene fusions.

METTL3-Dependent m6a RNA Methylation Suppresses Aberrant Mammary Epithelial Differentiation and Neoplastic Transformation

November 20, 2025

[Proceedings of The National Academy of Sciences of The United States of America] Scientists showed that METTL3-dependent m6A methylation is essential for maintaining epithelial hierarchy by repressing aberrant luminal gene expression.

RPS24 Microexon Isoform As a Novel Biomarker for Estrogen Receptor-Positive Breast Cancer Progression and Therapeutic Resistance

November 20, 2025

[Experimental & Molecular Medicine] The authors identified notable variations in ribosomal protein S24 (RPS24) splicing patterns across breast cancer subtypes and investigated this novel regulatory mechanism.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.