Mammary Cell News | Science News

LncRNA SEMA3B-AS1 Inhibits Breast Cancer Progression by Targeting miR-3940/Klln Axis

September 29, 2022

[Cell Death & Disease] The authors investigated the functional role of a novel long noncoding RNA SEMA3B-AS1 (lncRNA SEAS1) in breast cancer progression and the underlying mechanisms.

CircSEMA4B Inhibits the Progression of Breast Cancer by Encoding a Novel Protein SEMA4B-211aa and Regulating AKT Phosphorylation

September 29, 2022

[Cell Death & Disease] Researchers discovered a circRNA which encoded a novel protein, SEMA4B-211aa. Both circSEMA4B and SEMA4B-211aa were remarkably downregulated in breast cancer tissues and cell lines.

Effects of Aflatoxin B1 on Human Breast Cancer (MCF-7) Cells: Cytotoxicity, Oxidative Damage, Metabolic, and Immune-Modulatory Transcriptomic Changes

September 29, 2022

[Environmental Science and Pollution Research] The authors investigated AFB1-associated effects on human breast cancer cell lines, MCF-7, and found that AFB1 caused significant cytotoxicity on MCF-7 cells.

Histocompatibility Minor 13 (HM13), Targeted by miR-760, Exerts Oncogenic Role in Breast Cancer by Suppressing Autophagy and Activating PI3K-AKT-mTOR Pathway

September 29, 2022

[Cell Death & Disease] Scientists uncovered that HM13 was highly expressed in breast cancer and correlated with worse prognosis. Downregulation of HM13 could suppress breast cancer cell proliferation and metastasis abilities.

TGFB2-AS1 Inhibits Triple-Negative Breast Cancer Progression via Interaction With SMARCA4 and Regulating Its Targets TGFB2 and SOX2

September 29, 2022

[Proceedings of the National Academy of Sciences of the United States of America] Investigators revealed that TGFB2-AS1 impaired the breast cancer stem-like cell traits of TNBC cells in vitro and dramatically decreases tumorigenic frequency and lung metastasis in vivo.

β-Escin Overcomes Trastuzumab Resistance in HER2-Positive Breast Cancer by Targeting Cancer Stem-Like Features

September 29, 2022

[Cancer Cell International] The effect of β-escin on trastuzumab-resistant and -sensitive cell lines in vitro was evaluated for apoptosis, expression of HER2 family members, and impact on cancer stem cell-like properties.

Loss of SNAI1 Induces Cellular Plasticity in Invasive Triple-Negative Breast Cancer Cells

September 29, 2022

[Cell Death & Disease] SNAI1 knockout cells exhibited plasticity in differentiation, drifting towards the luminal phenotype, gained stemness potential, and could differentiate into acinar mammospheres in 3D culture.

Deep Whole Genome Sequencing Identifies Recurrent Genomic Alterations in Commonly Used Breast Cancer Cell Lines and Patient-Derived Xenograft Models

September 29, 2022

[Breast Cancer Research] Researchers identified novel genomic alterations, including point mutations and genomic rearrangements at base-pair resolution.

The Role of RAS Oncogenes in Controlling Epithelial Mechanics

September 29, 2022

[Trends in Cell Biology] Investigators discuss the role of oncogenic RAS in controlling mechanical cell phenotypes, and how these mechanical changes promote oncogenic transformation in single cells and tissues.

Therapeutics Targeting the Metastatic Breast Cancer Bone Microenvironment

September 29, 2022

[Pharmacology & Therapeutics] The authors discuss therapeutics targeting metastatic bresat cancer cells, bone cells, immune cells, and other stromal cells in the bone tumor microenvironment, including treatments that are currently used in the clinic, under development, and are potential new avenues for therapy.

90 New Grants To Outsmart Cancer, Totalling $10.8 Million

September 29, 2022

[Cancer Research Society] The Cancer Research Society is awarding 90 new research grants valued at $10.8 million as part of its annual competition. It is an all-time record for the organization for a second year in a row. The grants are awarded to some of the most promising cancer research projects in Canada.

β-Escin Overcomes Trastuzumab Resistance in HER2-Positive Breast Cancer by Targeting Cancer Stem-Like Features

September 28, 2022

[Cancer Cell International] The effect of β-escin on trastuzumab-resistant and -sensitive cell lines in vitro was evaluated for apoptosis, expression of HER2 family members, and impact on CSC-like properties.