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Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
Ectonucleotidase Activity Driven by Acid Ectophosphatase in Luminal a MCF-7 Breast Cancer Cells
[Cell Biology International] Investigators showed that AMP dose-dependently inhibited p-nitrophenylphosphate (p-NPP) hydrolysis. The p-NPP and AMP hydrolysis showed similar biochemical behaviors, such as increased hydrolysis under acidic conditions and comparable inhibition by NiCl2, ammonium molybdate, and sodium orthovanadate.
ALYREF Enhances Breast Cancer Progression by Regulating EZH2
[Heliyon] Scientists compared the canine mammary tumor histone H3 lysine 4 trimethylation landscape with that in human breast cancer.
Transient Splicing Inhibition Causes Persistent DNA Damage and Chemotherapy Vulnerability in Triple-Negative Breast Cancer
[Cell Reports] Researchers identified the spliceosome U2 small nuclear ribonucleoprotein particle complex as a modulator of chemotherapy efficacy in TNBC.
Navigating Heme Pathways: The Breach of Heme Oxygenase and Hemin In Breast Cancer
[Molecular and Cellular Biochemistry] The authors comprehensively examine recent advances in breast cancer research, with a focus on classification, molecular pathways, and the role of heme oxygenases, heme metabolism implications, and therapeutic innovations.
FDA Approves Novartis Kisqali® to Reduce Risk of Recurrence in People with HR+/HER2- Early Breast Cancer
[Novartis] Novartis announced that the US FDA has approved Kisqali® in combination with an aromatase inhibitor for the adjuvant treatment of people with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) stage II and III early breast cancer at high risk of recurrence.
FANCI Inhibition Induces PARP1 Redistribution to Enhance the Efficacy of PARP Inhibitors in Breast Cancer
[Cancer Research] Scientists identified the suppression of FANCI as a therapeutic strategy to enhance the efficacy of PARP inhibitors in breast cancer.
Breast Cancer Cell Derived Exosomes Reduces Glycolysis of Activated CD8+ T Cells in a AKT-mTOR Dependent Manner
[Cell Biology International] The authors observed reduction in glucose metabolism due to downregulation of AKT/mTOR signalome in activated CD8 + T cells after cancer derived exosome exposure.
Simultaneous Targeting of NQO1 and SOD1 Eradicates Breast Cancer Stem Cells via Mitochondrial Futile Redox Cycling
[Cancer Research] The authors identified the antioxidant enzymes NQO1 and SOD1 as therapeutic vulnerabilities of ALDH+ epithelial-like cancer stem-like cells (CSCs) and CD24-/loCD44+/hi mesenchymal-like CSCs in TNBC.
Caveolin-1 Knockout Mitigates Breast Cancer Metastasis to the Lungs via Integrin α3 Dysregulation in 4T1-Induced Syngeneic Breast Cancer Model
[Cancer Gene Therapy] The authors presented the first evidence that caveolin-1 knockout in mammary epithelial cells significantly reduced lung metastasis in syngeneic breast cancer mouse models.
Distinct Tumor Architectures and Microenvironments for the Initiation of Breast Cancer Metastasis in the Brain
[Cancer Cell] Using mouse models and human tissue samples, researchers found that TNBC and HER2+ tumor types colonized the brain, with a preference for distinctive tumor architectures, stromal interfaces, and autocrine programs.
LSD1 Inhibits the Invasion and Migration of Breast Cancer through Exosomes
[Scientific Reports] Researchers treated breast cancer cells with MCF7 and T47D exosomes knocked down by lysine specific demethylase 1 (LSD1), and the invasion and migration of breast cancer cells were significantly enhanced.
GATA3 and Markers of Epithelial-Mesenchymal Transition Predict Long-Term Benefit from Tamoxifen in ER-Positive Breast Cancer
[npj Breast Cancer] Scientists investigated tumoral GATA3 in a cohort of postmenopausal patients with lymph-node negative breast cancer, randomized to adjuvant tamoxifen or control.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
