Menarini Ricerche announced the results of the dose escalation part of its B-PRECISE-01 clinical trial which evaluated MEN1611, a potent and selective phosphatidylinositol 3-kinase inhibitor in development for the treatment of breast cancer.
The authors performed a dual-luciferase-based, genome-wide E3 ligase siRNA library screen and identified ASB13 as an E3 ubiquitin ligase that targeted SNAI2 for ubiquitination and degradation.
[Genes & Development]
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Researchers found that the hyperthermia window of 43–45 °C was maintained for one hour at the smallest possible concentration of 0.35 mg/mL without altering the magnetic field applicator parameters. Their hyperthermic effect on HeLa and MCF7 was investigated at the magnetic field of 15.3 kA/m and frequency 330 kHz, which was close to the upper safety limit of 5 * 109 A/m s.
Immunomedics, Inc.announced that Trodelvy™ delivered 150-fold and 40-fold the 50% inhibitory concentration of SN-38 for brain metastasis from breast cancer and recurrent glioblastoma, respectively, and produced partial responses in both cohorts of brain cancer patients.
Researchers used high‐throughput single‐cell RNA‐seq data to investigate the role of long non‐coding RNAs (lncRNAs) using the hierarchical model of mammary epithelium.
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Single‐cell profiling of lncRNAs and their cell lineage commitment roles via RNA‐DNA‐DNA triplex formation in mammary epithelium - Xu - - STEM CELLS - Wiley Online Library. (n.d.). Retrieved September 17, 2020, from https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.3274 Cite
Using the recently established culturing method that allowed propagation of normal and cancerous breast epithelial cells of luminal origin, flow cytometry characterization, and genomic sequencing, scientists showed that cancer cells were detected in breast milk.
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A mechanistic investigation showed that EIF1AX inhibited the expression of p21, which is an essential cell cycle regulator.
Investigators report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle loaded with the near-infra-red fluorescent dye DiR-BOA for sentinel lymph nodes imaging in breast cancer.
[Light: Science & Applications]
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Dai, Y., Yu, X., Wei, J., Zeng, F., Li, Y., Yang, X., Luo, Q., & Zhang, Z. (2020). Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles. Light: Science & Applications, 9(1), 164. https://doi.org/10.1038/s41377-020-00399-0 Cite
The authors address the effect of malignant cells, adjuvant therapies and patient-specific factors that may influence the success of regenerative strategies using adipose derived stromal cells (ADSCs) for post cancer tissue regeneration.
[Stem Cell Reviews and Reports]
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Challapalli, R. S., Dwyer, R. M., McInerney, N., Kerin, M. J., & Lowery, A. J. (2020). Effect of Breast Cancer and Adjuvant Therapy on Adipose-Derived Stromal Cells: Implications for the Role of ADSCs in Regenerative Strategies for Breast Reconstruction. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10038-1 Cite
Researchers explored the metastasis associated negative effect of chronic stress.
[Cell Death & Disease]
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Du, P., Zeng, H., Xiao, Y., Zhao, Y., Zheng, B., Deng, Y., Liu, J., Huang, B., Zhang, X., Yang, K., Jiang, Y., & Ma, X. (2020). Chronic stress promotes EMT-mediated metastasis through activation of STAT3 signaling pathway by miR-337-3p in breast cancer. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02981-1 Cite
To determine potential biomarkers of palbociclib sensitivity to assist in patient selection and clinical development, scientists investigated the effects of palbociclib in a panel of molecularly characterized breast cancer cell lines.
[Cell Death & Disease]
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