Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Progressive Senescence Programs Induce Intrinsic Vulnerability to Aging-Related Female Breast Cancer

[Nature Communications] Investigators found that the mammary aging process was asynchronous and progressive, initiated by an early senescence program, succeeded by an entropic late senescence program with elevated cancer associated pathways, vulnerable to cancer predisposition.

Xylyx Bio Awarded $2.26M NIH SBIR Grant from National Cancer Institute

[Xylyx Bio, Inc. (BioSpace)] Xylyx Bio, Inc. announced that it has been awarded a Small Business Innovation Research (SBIR) Fast-Track grant from the National Cancer Institute of the National Institutes of Health (NIH) to advance commercial development of its InMatrico® disease modeling and drug testing platform to help scientists discover and test drug candidates for metastatic breast cancer.

DUSP6 Inhibition Overcomes Neuregulin/HER3-Driven Therapy Tolerance in HER2+ Breast Cancer

[EMBO Molecular Medicine] Investigators presented transcriptional profiling of HER2+ breast cancer cells transitioning from dormant drug tolerant cells to re-proliferating cells under continuous HER2 inhibitor therapy. Expression of dual-specificity phosphatase DUSP6 was found inhibited in dormant cells, but strongly induced upon regrowth.

Targeting LINC00152 Activates cAMP/Ca2+/Ferroptosis Axis and Overcomes Tamoxifen Resistance in ER+ Breast Cancer

[Cell Death & Disease] Researchers identified LINC00152 inhibition as a novel mechanism of tamoxifen sensitization via restoring tamoxifen-dependent ferroptosis upon destabilizing phosphodiesterase 4D, increasing cAMP and Ca2+ levels, thus leading to reactive oxygen species generation and lipid peroxidation.

Ferroptosis as a Promising Targeted Therapy for Triple Negative Breast Cancer

[Breast Cancer Research and Treatment] The authors utilize a multifaceted approach to investigate the induction of ferroptosis as a therapeutic strategy for TNBC. They explore metabolic alterations, redox imbalance, and oncogenic signaling pathways to understand their roles in inducing ferroptosis, characterized by lipid peroxidation, reactive oxygen species (ROS) generation, and altered cellular morphology.

UM171 Suppresses Breast Cancer Progression by Inducing KLF2

[Breast Cancer Research and Treatment] Investigators showed potent anti-neoplastic activity of the UM171 compound on breast cancer cells and its mechanism of action. UM171-mediated growth inhibition was associated with the induction of apoptosis, G2/M cell cycle arrest, lower colony-forming capacity, and reduced motility.

NIH Awards Younghye Song $2.5 Million to Study Metabolic Rewiring in Breast Tumor Innervation

[University of Arkansas] Younghye Song, assistant professor of biomedical engineering in the U of Arkansas's College of Engineering, has recently been awarded a $2.5 million National Institutes of Health R37 grant from the National Cancer Institute to investigate the role of metabolic rewiring in breast tumor innervation.

NIH Awards Younghye Song $2.5 Million to Study Metabolic Rewiring in Breast Tumor Innervation

Younghye Song, assistant professor of biomedical engineering in the U of Arkansas's College of Engineering, has recently been awarded a $2.5 million National Institutes...

UNF Faculty Receive Patent for Discovering Cancer-Fighting Compound That Could ‘Turn Off’ Cancer

[University of North Florida] Three University of North Florida (UNF) researchers have been awarded a US patent for a targeted cancer-fighting compound, or peptoid, that the team has discovered targets certain breast, colon and lung cancers and stops them from progressing. This promising discovery could lead to significantly better patient outcomes for difficult to treat cancers.

The Multifaceted Role of SOX2 in Breast and Lung Cancer Dynamics

[Pathology - Research and Practice] SOX2, known for its abnormal expression in various human cancers, can either accelerate or impede cancer progression. The authors focus on examining the role of SOX2 in breast and lung cancer development.

NIH Wanted to Make Cancer Research More Diverse. The Effort Turned Out to Be a Costly Failure

[STAT News] The NCI’s Center for Cancer Research piloted a program of paying the travel costs for screening prospective research volunteers and, when needed, their caregivers, according to an internal NCI email obtained by STAT. NCI discontinued the pilot after one year, according to an NCI spokesperson.

Pure Estrogen Receptor Antagonists Potentiate Capecitabine Activity in ESR1-Mutant Breast Cancer

[NPJ Breast Cancer] Investigators conducted comprehensive pre-clinical in vitro and in vivo experiments testing the efficacy of adding fulvestrant to fluorouracil (5FU) and the 5FU pro-drug, capecitabine, in models of wild-type and mutant estrogen receptor.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.