Antagonists of the Serotonin Receptor 5A Target Human Breast Tumor Initiating Cells

Researchers found that selective antagonists of 5-HT5A reduced the frequency of tumorsphere initiating cells residing in breast tumor cell lines and those of patient-derived xenografts that they established.
[BMC Cancer]
Gwynne, W. D., Shakeel, M. S., Girgis-Gabardo, A., Kim, K. H., Ford, E., Dvorkin-Gheva, A., Aarts, C., Isaac, M., Al-awar, R., & Hassell, J. A. (2020). Antagonists of the serotonin receptor 5A target human breast tumor initiating cells. BMC Cancer, 20(1), 724. https://doi.org/10.1186/s12885-020-07193-6 Cite
Full Article

Continue reading “Antagonists of the Serotonin Receptor 5A Target Human Breast Tumor Initiating Cells”

Bookmark

No account yet? Register

0
Share

Rosmarinic Acid-Induced Apoptosis and Cell Cycle Arrest in Triple-Negative Breast Cancer Cells

Researchers evaluated the effects and mechanisms of rosmarinic acid (RA) in two racially different TNBC cell lines. Results obtained showed that RA significantly caused cytotoxic and antiproliferative effects in both cell lines in a dose- and time-dependent manner. RA induced cell cycle arrest-related apoptosis and altered the expression of many apoptosis-involved genes differently.
[European Journal of Pharmacology]
Messeha, S. S., Zarmouh, N. O., Asiri, A., & Soliman, K. F. A. (2020). Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. European Journal of Pharmacology, 173419. https://doi.org/10.1016/j.ejphar.2020.173419 Cite
Full ArticleGraphical Abstract

Continue reading “Rosmarinic Acid-Induced Apoptosis and Cell Cycle Arrest in Triple-Negative Breast Cancer Cells”

Bookmark

No account yet? Register

0
Share

Distinct Phenotypes of Cancer Cells on Tissue Matrix Gel

Scientists investigated mammary epithelial cell phenotypes and metabolic profiles on animal breast extracellular matrix-derived tissue matrix gel, Col I, and Matrigel. Atomic force microscopy, fluorescence microscopy, acini formation assay, differentiation experiments, spatial migration/invasion assays, proliferation assay, and nuclear magnetic resonance spectroscopy were used to examine biological phenotypes and metabolic changes.
[Breast Cancer Research]
Distinct phenotypes of cancer cells on tissue matrix gel | Breast Cancer Research | Full Text. (n.d.). Retrieved August 6, 2020, from https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-01321-7 Cite
Full Article

Continue reading “Distinct Phenotypes of Cancer Cells on Tissue Matrix Gel”

Bookmark

No account yet? Register

0
Share

PRMT1-Dependent Methylation of BRCA1 Contributes to the Epigenetic Defense of Breast Cancer Cells against Ionizing Radiation

Investigators found that by activating PRMT1, irradiation triggered a BRCA1-dependent program that resulted in efficient DNA repair and inhibition of apoptosis. Depletion of PRMT1 in irradiated cells resulted in a switch of BRCA1 functions from repair and survival in the nucleus to activation of cell death signals in the cytoplasm.
[Scientific Reports]
PRMT1-dependent methylation of BRCA1 contributes to the epigenetic defense of breast cancer cells against ionizing radiation | Scientific Reports. (n.d.). Retrieved August 6, 2020, from https://www.nature.com/articles/s41598-020-70289-3 Cite
Full Article

Continue reading “PRMT1-Dependent Methylation of BRCA1 Contributes to the Epigenetic Defense of Breast Cancer Cells against Ionizing Radiation”

Bookmark

No account yet? Register

0
Share

Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

The nanocomplexes formed by metallodendrimers and different siRNA were examined for their zeta potential and size, and by transmission electron microscopy, fluorescence polarisation, circular dichroism, and electrophoresis. The internalisation of dendriplexes was estimated by flow cytometry and confocal microscopy in a human breast cancer cell line, following the ability of these metallodendrimers to deliver the siRNA into the cell. In vitro cell viability experiments have indicated effective interactions between Cu (II) dendrimers and pro-apoptotic siRNAs: Mcl-1 and Bcl-2 in breast cancer cells.
[Pharmaceutics]
Sanz del Olmo, N., Holota, M., Michlewska, S., Gómez, R., Ortega, P., Ionov, M., de la Mata, F. J., & Bryszewska, M. (2020). Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells. Pharmaceutics, 12(8), 727. https://doi.org/10.3390/pharmaceutics12080727 Cite
Full ArticleGraphical Abstract

Continue reading “Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells”

Bookmark

No account yet? Register

0
Share

Daiichi Sankyo and AstraZeneca Enter New Global Development and Commercialization Collaboration for Daiichi Sankyo’s ADC DS-1062

Daiichi Sankyo Company, Limited announced that it has entered into a global development and commercialization agreement with AstraZeneca for Daiichi Sankyo’s DS-1062, a TROP2 directed DXd antibody drug conjugate, currently in Phase I clinical development for non-small cell lung cancer and TNBC.
[Daiichi Sankyo Ltd.]
Press Release

Continue reading “Daiichi Sankyo and AstraZeneca Enter New Global Development and Commercialization Collaboration for Daiichi Sankyo’s ADC DS-1062”

Bookmark

No account yet? Register

0
Share

Merck Announces Two US Regulatory Milestones for KEYTRUDA® (pembrolizumab) in Triple-Negative Breast Cancer (TNBC)

Merck announced that the FDA has accepted two new supplemental Biologics License Applications for KEYTRUDA, Merck’s anti-PD-1 therapy.
[Merck]
Press Release

Continue reading “Merck Announces Two US Regulatory Milestones for KEYTRUDA® (pembrolizumab) in Triple-Negative Breast Cancer (TNBC)”

Bookmark

No account yet? Register

0
Share

AUF1 Promotes Stemness in Human Mammary Epithelial Cells through Stabilization of the EMT Transcription Factors TWIST1 and SNAIL1

Scientists showed that AU-rich element RNA-binding protein 1 was an important inducer of the epithelial-to-mesenchymal transition process through stabilization of SNAIL1 and TWIST1 and the consequent promotion of breast cancer stem cells.
[Oncogenesis]
AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1 | Oncogenesis. (n.d.). Retrieved August 6, 2020, from https://www.nature.com/articles/s41389-020-00255-1 Cite
Full Article

Continue reading “AUF1 Promotes Stemness in Human Mammary Epithelial Cells through Stabilization of the EMT Transcription Factors TWIST1 and SNAIL1”

Bookmark

No account yet? Register

0
Share

Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions

Researchers summarized recent literature regarding molecules and pathways and reviewed the effects of cancer stem cells biology during the formation of brain metastasis in TNBC.
[Cancers]
Lee, K.-L., Chen, G., Chen, T.-Y., Kuo, Y.-C., & Su, Y.-K. (2020). Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions. Cancers, 12(8), 2122. https://doi.org/10.3390/cancers12082122 Cite
Full Article

Continue reading “Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions”

Bookmark

No account yet? Register

0
Share

Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer

The authors defined the differential responses to trametinib in subpopulations of a clinically-relevant in vitro model of TNBC, and identified both adaptive and acquired elements that contribute to the emergence of drug resistance mediated by increased expression of CXCR7 and amplification of KRAS.
[Molecular Cancer Research]
Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer | Molecular Cancer Research. (n.d.). Retrieved August 6, 2020, from https://mcr.aacrjournals.org/content/early/2020/08/04/1541-7786.MCR-19-1011 Cite
Abstract

Continue reading “Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer”

Bookmark

No account yet? Register

0
Share

Hyaluronic Acid Optimises Therapeutic Effects of Hydrogen Peroxide‐Induced Oxidative Stress on Breast Cancer

To better define the effects of oxidative stress, in vitro experiments were conducted on 4T1 and splenic mononuclear cells under hypoxic and normoxic conditions. Hydrogen peroxide was used as an reactive oxygen species source alone or in combination with hyaluronic acid.
[Journal of Cellular Physiology]
Hyaluronic acid optimises therapeutic effects of hydrogen peroxide‐induced oxidative stress on breast cancer - Abbasi - - Journal of Cellular Physiology - Wiley Online Library. (n.d.). Retrieved August 6, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29957 Cite
Abstract

Continue reading “Hyaluronic Acid Optimises Therapeutic Effects of Hydrogen Peroxide‐Induced Oxidative Stress on Breast Cancer”

Bookmark

No account yet? Register

0
Share

Natural Polysaccharide Derived Carbon Dot Based In Situ Facile Green Synthesis of Silver Nanoparticles: Synergistic Effect on Breast Cancer

Carbon dot showed selective cytotoxicity against MCF7 breast cancer cells with the IC50 of 10 μg/ml while carbon dot based silver nanoparticles demonstrated synergistic effect on cytotoxicity.
[International Journal of Biological Macromolecules]
Ghosal, K., Ghosh, S., Ghosh, D., & Sarkar, K. (2020). Natural polysaccharide derived carbon dot based in situ facile green synthesis of silver nanoparticles: Synergistic effect on breast cancer. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.07.315 Cite
AbstractGraphical Abstract

Continue reading “Natural Polysaccharide Derived Carbon Dot Based In Situ Facile Green Synthesis of Silver Nanoparticles: Synergistic Effect on Breast Cancer”

Bookmark

No account yet? Register

0
Share
Share