Inhibiting β-Catenin Disables Nucleolar Functions in Triple-Negative Breast Cancer

Investigators demonstrated that LAS1 like ribosome biogenesis factor protein expression was significantly elevated in TNBC patients, and it functionally was important for mammary tumor growth in xenograft models and enabled invasive attributes.
[Cell Death & Disease]
Weeks, S. E., Kammerud, S. C., Metge, B. J., AlSheikh, H. A., Schneider, D. A., Chen, D., Wei, S., Mobley, J. A., Ojesina, A. I., Shevde, L. A., & Samant, R. S. (2021). Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancer. Cell Death & Disease, 12(3), 1–13. https://doi.org/10.1038/s41419-021-03531-z Cite
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BCDIN3D RNA Methyltransferase Stimulates Aldolase C Expression and Glycolysis through Let-7 MicroRNA in Breast Cancer Cells

In order to uncover metabolic pathways regulated by BCDIN3D in cancer, we performed an unbiased analysis of the metabolome, transcriptome, and proteome of breast cancer cells depleted for BCDIN3D.
[Oncogene]
BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through let-7 microRNA in breast cancer cells | Oncogene. (n.d.). Retrieved March 4, 2021, from https://www.nature.com/articles/s41388-021-01702-y Cite
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Epithelial to Mesenchymal Transition and MicroRNA Expression Are Associated with Spindle and Apocrine Cell Morphology in Triple-Negative Breast Cancer

The authors analyzed miRNA expression within areas of TNBCs with cellular morphology that may be related to the epithelial to mesenchymal transition process and discuss possible associations.
[Scientific Reports]
Koleckova, M., Ehrmann, J., Bouchal, J., Janikova, M., Brisudova, A., Srovnal, J., Staffova, K., Svoboda, M., Slaby, O., Radova, L., Vomackova, K., Melichar, B., Veverkova, L., & Kolar, Z. (2021). Epithelial to mesenchymal transition and microRNA expression are associated with spindle and apocrine cell morphology in triple-negative breast cancer. Scientific Reports, 11(1), 5145. https://doi.org/10.1038/s41598-021-84350-2 Cite
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Allarity Therapeutics Initiates Phase II Trial of IXEMPRA® in Europe for the Treatment of Metastatic Breast Cancer

Allarity Therapeutics A/S announced that it has enrolled the first patient in its European Phase II clinical trial of IXEMPRA® for the treatment of metastatic breast cancer.
[Allarity Therapeutics A/S]
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Kintara Therapeutics Appoints Dr. Mario Lacouture to Scientific Advisory Board for Cutaneous Metastatic Breast Cancer

Kintara Therapeutics, Inc.announced the appointment of Mario Lacouture, to the REM-001 Scientific Advisory Board with the initial focus in Cutaneous Metastatic Breast Cancer.
[Kintara Therapeutics, Inc.]
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Involvement of Actin Cytoskeletal Modifications in the Inhibition of Triple Negative Breast Cancer Growth and Metastasis by Nimbolide

The authors demonstrated the growth and metastasis inhibitory potential of nimbolide on TNBC cells. Nimbolide inhibited cell proliferation, migratory, and invasive abilities of TNBC cells and also changed the shape of MDA-MB-231 cells, which is correlated with cytoskeletal changes including actin depolymerization.
[Molecular Therapy-Oncolytics]
Arumugam, A., Subramani, R., & Lakshmanaswamy, R. (2021). Involvement of actin cytoskeletal modifications in the inhibition of triple negative breast cancer growth and metastasis by nimbolide. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.02.014 Cite
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The Onco-Immunological Implications of F. nucleatum in Breast Cancer

Scientists discuss the breast tumor microbiota, its colonization by F. nucleatum, possible mechanisms by which F. nucleatum might promote breast cancer progression and how this might impact breast cancer treatment.
[Immunology Letters]
van der Merwe, M., Van Niekerk, G., Botha, A., & Engelbrecht, A.-M. (2021). The Onco-immunological Implications of F nucleatum in Breast Cancer. Immunology Letters. https://doi.org/10.1016/j.imlet.2021.02.007 Cite
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Lysyl Oxidase Engineered Lipid Nanovesicles for the Treatment of Triple Negative Breast Cancer

The authors demonstrated that, when the conjugated vesicles were loaded with the chemotherapeutic epirubicin, superior inhibition of TNBC cell growth was observed both in vitro and in vivo.
[Scientific Reports]
De Vita, A., Liverani, C., Molinaro, R., Martinez, J. O., Hartman, K. A., Spadazzi, C., Miserocchi, G., Taraballi, F., Evangelopoulos, M., Pieri, F., Bongiovanni, A., Mercatali, L., Tasciotti, E., & Ibrahim, T. (2021). Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer. Scientific Reports, 11(1), 5107. https://doi.org/10.1038/s41598-021-84492-3 Cite
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TAp73 Represses NF-κB–Mediated Recruitment of Tumor-Associated Macrophages in Breast Cancer

Scientists report that low levels of TAp73 correlated with an increased NF-κB–regulated inflammatory signature in breast cancer.
[Proceedings of the National Academy of Sciences of the United States of America]
Wolfsberger, J., Sakil, H. A. M., Zhou, L., Bree, N. van, Baldisseri, E., Ferreira, S. de S., Zubillaga, V., Stantic, M., Fritz, N., Hartman, J., Rolny, C., & Wilhelm, M. T. (2021). TAp73 represses NF-κB–mediated recruitment of tumor-associated macrophages in breast cancer. Proceedings of the National Academy of Sciences, 118(10). https://doi.org/10.1073/pnas.2017089118 Cite
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Oncogenic Translation Directs Spliceosome Dynamics Revealing an Integral Role for SF3A3 in Breast Cancer

The authors revealed that SF3A3 protein levels predict molecular and phenotypic features of aggressive human breast cancers.
[Molecular Cell]
Cieśla, M., Ngoc, P. C. T., Cordero, E., Martinez, Á. S., Morsing, M., Muthukumar, S., Beneventi, G., Madej, M., Munita, R., Jönsson, T., Lövgren, K., Ebbesson, A., Nodin, B., Hedenfalk, I., Jirström, K., Vallon-Christersson, J., Honeth, G., Staaf, J., Incarnato, D., … Bellodi, C. (2021). Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer. Molecular Cell, 0(0). https://doi.org/10.1016/j.molcel.2021.01.034 Cite
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Loss of BRCA1 Expression and Morphological Features Associated with BRCA1 Promoter Methylation Status in Triple-Negative Breast Cancer

The authors investigated the possibility to predict BRCA1 promoter methylation status based on the morphological and immunohistochemical features of TNBCs.
[Journal of Human Genetics]
Morizono, A., Tanabe, M., Ikemura, M., Sasaki, T., Ushiku, T., & Seto, Y. (2021). Loss of BRCA1 expression and morphological features associated with BRCA1 promoter methylation status in triple-negative breast cancer. Journal of Human Genetics, 1–9. https://doi.org/10.1038/s10038-021-00911-3 Cite
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