Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Ferroptosis Surveillance Independent of GPX4 and Differentially Regulated by Sex Hormones

[Cell] Through a whole-genome CRISPR activation screen, followed by mechanistic investigation, researchers identified phospholipid-modifying enzymes MBOAT1 and MBOAT2 as ferroptosis suppressors.

RPI and Albany Medical College Researchers Awarded $3.3 Million To Improve Breast Cancer Treatment Using Artificial Intelligence

[Albany Medical College] Researchers from Rensselaer Polytechnic Institute (RPI) and Albany Medical College were awarded a $3.3 million grant over five years by the National Cancer Institute to use artificial intelligence to improve targeted drug therapy in HER2-positive breast cancer treatment.

ALDH1L2 Regulation of Formate, Formyl-Methionine, and ROS Controls Cancer Cell Migration and Metastasis

[Cell Reports] Using breast cancer cell lines, scientists showed that reduction of aldehyde dehydrogenase 1 family member 2 (ALDH1L2) expression increased ROS levels and the production of both formate and formyl-methionine.

Resistance to Mesenchymal Reprogramming Sustains Clonal Propagation in Metastatic Breast Cancer

[Cell Reports] The authors isolated epithelial and mesenchymal populations from human breast cancer metastatic biopsies and assessed their functional potential in vivo. Progressively decreasing epithelial cell adhesion molecule levels correlated with declining disease propagation.

CDK4/6 Inhibitors and the pRB-E2F1 Axis Suppress PVR and PD-L1 Expression in Triple-Negative Breast Cancer

[Oncogenesis] Investigators showed that RB-loss and high E2F1/E2F2 signatures correlated with expression of poliovirus receptor (PVR), CD274 and other immune-checkpoint modulators and that pRB repressed whereas RB depletion and E2F1 induced PVR and CD274 in TNBC cells.

Targeting Long Non-Coding RNA MALAT1 Reverses Cancerous Phenotypes of Breast Cancer Cells through microRNA-561-3p/TOP2A Axis

[Scientific Reports] Researchers determined the correlation between miR-561-3p and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and their roles in breast cancer (BC) progression. The expression of MALAT1, mir-561-3p, and topoisomerase alpha 2 (TOP2A) as a target of miR-561-3p was determined in BC clinical samples and cell lines via qRT-PCR.

Overexpression of Cannabinoid Receptor 2 Is Associated with Human Breast Cancer Proliferation, Apoptosis, Chemosensitivity, and Prognosis via the PI3K/Akt/mTOR Signaling Pathway

[Cancer Medicine] The authors examined the expression and prognostic significance of cannabinoid receptor 2 in breast cancer tissues by qPCR, second-generation sequencing, western blot, and immunohistochemistry.

Downregulation of the Long Noncoding RNA DSCR9 (Down Syndrome Critical Region 9) Delays Breast Cancer Progression by Modulating microRNA-504-5p-Dependent G Protein-Coupled Receptor 65

[Human Cell] Investigators focused on the regulatory function of the lncRNA DSCR9 in breast cancer stem cells (BCSCs). Through bioinformatics analysis, DSCR9, microRNA-504-5p, and G protein-coupled receptor 65 were identified as targets implicated in breast cancer development.

Potential Anticancer Properties of Calotropis procera: An Investigation on Breast and Colon Cancer Cells

[Heliyon] The antiproliferative effects of Calotropis procera were investigated on two cancer cell lines: human colon (HCT-116) and breast (MCF-7) cancer. The effectiveness of the plant extract on the cytotoxicity, apoptosis, cell cycle progression, genes involved in the cell cycle, and protein expression profiles of HCT-116 and MCF-7 cells was analyzed.

Antioxidant Capacity and Cytotoxic Effect of an Optimized Extract of Isabella Grape (Vitis labrusca) on Breast Cancer Cells

[Heliyon] In order to better understand the phenolic compounds found in Isabella grape and the biological effect they induce on breast cancer cells, an ultrasound-assisted extraction was carried out.

Potential Activity of Adiponectin-Expressing Regulatory T Cells Against Triple-Negative Breast Cancer Cells through the Cell-in-Cell Phenomenon

[Thoracic Cancer] CD4- and CD25-positive cells were sorted from cultured T lymphocytes of a previously characterized experimental thymic tumor model composed of thymic nurse cells and abundant lymphoid stroma.

Isolation and Purifications of an Ambuic Acid Derivative Compound from Marine Algal Endophytic Fungi Talaromyces flavus That Induces Apoptosis in MDA-MB-231 Cancer Cells

[Chemical Biology & Drug Design] An ambuic acid derivative anticancer compound was isolated from Talaromyces flavus, and its cytotoxicity and apoptosis induction potential were analyzed.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.