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Mammary Cell News
Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
Targeting Mutant p53: A Key Player in Breast Cancer Pathogenesis and Beyond
[Cell Communication and Signaling] Investigators delve into current and novel treatment approaches aimed at targeting p53 mutations, taking into account the similarities and differences in p53 regulatory mechanisms between mutant and wild-type forms, as well.
LN-439A, a Novel BAP1 Inhibitor, Suppresses the Growth of Basal-Like Breast Cancer by Degrading KLF5
[Acta Pharmacologica Sinica] Scientists identified a series of tetrahydro-β-carboline derivatives that effectively reduced the protein expression of Krüppel-like factor 5 (KLF5) and exhibited strong antitumour activity.
AKT and EZH2 Inhibitors Kill TNBCs by Hijacking Mechanisms of Involution
[Nature] The authors described a promising AKT-inhibitor-based therapeutic combination for TNBC. They showed show that AKT inhibitors synergized with agents that suppressed the histone methyltransferase EZH2 and promoted robust tumor regression in multiple TNBC models in vivo.
A Preoperative Window-of-Opportunity Study of Oral SERD, Imlunestrant, in Newly Diagnosed ER-Positive, HER2-Negative Early Breast Cancer: Results from EMBER-2 Study.
[Clinical Cancer Research] Postmenopausal women with untreated, operable ER-positive, HER2-negative early breast cancer were randomized to 400mg vs 800mg of imlunestrant daily for around 2 weeks before surgery.
Midkine as a Driver of Age-Related Changes and Increase in Mammary Tumorigenesis
[Cancer Cell] Researchers discovered a luminal progenitor population unique to old rats with profiles reflecting precancerous changes and identified midkine as a gene upregulated with age and a regulator of age-related luminal progenitors.
Enhancing the Safety and Efficacy of Trastuzumab Emtansine (T-DM1) Through Nano-Delivery System in Breast Cancer Therapy
[Small] Scientists investigated the feasibility of using poly(lactic-co-glycolic acid) nanoparticles as a delivery vehicle to conjugate T-DM1, aiming to alleviate T-DM1-induced thrombocytopenia.
Induction of the TEAD Co-activator VGLL1 by Estrogen Receptor-Targeted Therapy Drives Resistance in Breast Cancer
[Cancer Research] By analyzing histone H3 lysine 27 acetylation profiles and transcriptional reprogramming in models of endocrine therapy resistance, scientists discovered that selective estrogen receptor degraders promoted expression of VGLL1, a co-activator for TEAD transcription factors.
Functional Activation of the AKT-mTOR Signaling Axis in a Real-World Metastatic Breast Cancer Cohort
[British Journal of Cancer] Molecular profiles were generated by CLIA-certified laboratories from a real-world evidence cohort of 171 MBC patients. Genetic alterations of the PIK3CA pathway were measured using next-generation sequencing.
Characterization of APOBEC3B-Mediated RNA Editing in Breast Cancer Cells Reveals Regulatory Roles of NEAT1 and MALAT1 lncRNAs
[Oncogene] Researchers coupled an inducible expression cell model with a novel methodology for identifying differential variants in RNA to map A3B-mediated RNA editing sites in a breast cancer cell model.
Sacituzumab Govitecan in HR+HER2− Metastatic Breast Cancer: The Randomized Phase III EVER-132-002 Trial
[Nature Medicine] Investigators reported results of sacituzumab govitecan (SG) in Asian patients with hormone receptor-positive human epidermal growth factor receptor 2-negative (HR+HER2−) metastatic breast cancer from the EVER-132-002 study. Patients were randomized to SG or chemotherapy.
TMCO1 Is Upregulated in Breast Cancer and Regulates the Response to Pro-Apoptotic Agents in Breast Cancer Cells
[Cell Death Discovery] Scientists linked the overexpression of transmembrane and coiled-coil domains 1 (TMCO1) with prognosis in node-positive basal breast cancer patients.
UCF Medical Researchers Earn Grants for Innovative Approaches to Breast Cancer
Alicja Copik and Debbie Altomare each received $100,000 from the Florida Breast Cancer Foundation, a group focused on supporting innovative research that will create...
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
