Scientists investigated the therapeutic efficacy of the combination of 131I-trastuzumab and lanatoside C for inhibition of human epidermal growth factor receptor 2 (HER2) positive tumor progression in NCI-N87 xenograft model.
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Researchers used Cell Counting Kit-8, colony formation, wound healing migration, Transwell invasion, and nude mouse xenograft assays to confirm the role of the lncRNA actin filament-associated protein 1 antisense RNA1 (AFAP1-AS1) in the proliferation, migration of TNBC cells in vitro and in vivo.
[Cell Death & Disease]
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Buried in a bill approved by the US Senate to help the United States compete with China is language that is drawing fire from human genome researchers. It would require the NIH to develop new security protocols aimed at preventing the misuse of US-funded genomic data by China and other nations.
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Persistent cells were enriched for vimentinhigh sub-population, vimentin knockdown using siRNA approach decreased the invasive and sphere forming capacities as well as Akt phosphorylation in persistent cells, indicating that vimentin was involved in chemotherapeutic treatment-induced enhancement of TNBC aggressiveness.
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The authors presented a next-generation sequencing methylation-based blood test called methylation DETEction of Circulating Tumour DNA (mDETECT) designed for the optimal detection and monitoring of metastatic TNBC.
[npj Precision Oncology]
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USP35 promoted the growth of ER+ breast cancer in vitro and in vivo, and reduced the sensitivity of ER+ breast cancer cells to endocrine therapies such as tamoxifen and fulvestrant.
[Cell Death & Disease]
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Researchers evaluated cell death in mammospheres from MCF-7 and primary tumor cells in response to curcumin loaded on graphene nanosheets. The nanocarriers graphene oxide and graphene quantum dots had no cytotoxic effect on Kerman male breast cancer/71 and MCF-7 tumor cells, while those loaded with curcumin induced death in more than 50% of tumor cells.
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Scientists CRISPR-engineered RNA splice junctions to produce normal and early stage ductal carcinoma in situ breast epithelial cells that expressed only AIB1Δ4. These cells showed enhanced motility and invasion in 3D cell culture.
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Investigators constructed an integrin α2β1 targeting DGEA-modified liposomal doxorubicin platform for application in breast cancer therapy. Demonstrated in vitro and in vivo, the constructed platform exhibited improved antitumor ability.
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Reverse transcription-quantitative polymerase chain reaction was performed to confirm the downregulation of circ_0044234 in triple negative tumors and cell lines versus non-triple negative ones.
[Cancer Cell International]
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The authors summarize key discoveries that aid the clinical translation of PI3Kα and PI3Kδ inhibitors, including the PI3Kα isoform-selective inhibitor alpelisib for the treatment of breast cancer, highlighting lessons learnt and future opportunities.
[Nature Reviews Drug Discovery]
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