MLK4 Regulates DNA Damage Response and Promotes Triple-Negative Breast Cancer Chemoresistance

Investigators demonstrated that MLK4 promoted TNBC chemoresistance by regulating the pro-survival response to DNA-damaging therapies and identified a novel function of MLK4 in the regulation of DNA damage response signaling.
[Cell Death & Disease]
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Compressive Stress-Mediated p38 Activation Required for ERα + Phenotype in Breast Cancer

The authors examined 400 patient-derived breast epithelial and breast cancer explant cultures grown in various three-dimensional matrix scaffolds, and found that ERα was primarily regulated by the matrix stiffness.
[Nature Communications]
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Olfactory Receptor 5B21 Drives Breast Cancer Metastasis

Researchers examined the significance of olfactory receptor (OR) transcript abundance in primary and metastatic breast cancer to the brain, bone, and lung. Knockdown of OR5B21 significantly decreased the invasion and migration of breast cancer cells as well as metastasis to different organs.
[iScience]
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Distinct Contributions of Partial and Full EMT to Breast Cancer Malignancy

Researchers employed tamoxifen-inducible dual recombinase lineage tracing systems combined with live imaging and 5-cell RNA sequencing to track cancer cells undergoing partial or full epithelial-mesenchymal transition (EMT) in the MMTV-PyMT mouse model of metastatic breast cancer.
[Developmental Cell]
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Cancer-Associated Fibroblast-Derived Exosomal miR-18b Promotes Breast Cancer Invasion and Metastasis by Regulating TCEAL7

Scientists compared the effects of cancer-associated fibroblasts (CAFs)-derived exosomes and normal fibroblasts (NFs)-derived exosomes on breast cancer cells migration and invasion and showed that CAFs-derived exosomes had a more enhancing effect on breast cancer cells migration and invasion than NFs-derived exosomes.
[Cell Death & Disease]
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Ras Inhibitor Farnesylthiosalicylic Acid Conjugated with IR783 Dye Exhibits Improved Tumor-Targeting and Altered Anti-Breast Cancer Mechanisms in Mice

Investigators demonstrated that organic anion transporting polypeptide and endocytosis synergistically drove the uptake of the farnesylthiosalicylic acid-IR783 conjugate in breast cancer MDA-MB-231 cells, resulting in superior tumor-targeting ability of the conjugate both in vitro and in vivo.
[Acta Pharmacologica Sinica]
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Anti-Breast Cancer Synthetic Peptides Derived from the Anabas testudineus Skin Mucus Fractions

The authors characterized the anticancer activity of the A. testudineus antimicrobial peptides, which were synthetically produced and subjected to cytotoxic assay to prove their efficacy against cancer cell lines.
[Scientific Reports]
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Tetraspanin 1 (TSPAN1) Promotes Growth and Transferation of Breast Cancer Cells via Mediating PI3K/Akt Pathway

Researchers found high TSPAN1 expression in breast cancer tumor samples and cell lines which was confirmed by bioinformation analysis. The ablation of TSPAN1 suppressed the growth, and motility of breast cancer cells and affected the epithelial-mesenchymal transition in breast cancer cells.
[Bioengineered]
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Paxillin Promotes Breast Tumor Collective Cell Invasion through Maintenance of Adherens Junction Integrity

Scientists utilized a newly generated PyMT mammary tumor mouse model with conditional paxillin ablation in breast tumor epithelial cells, combined with in vitro 3D tumor organoids invasion analysis and 2D calcium switch assays, to assess the roles for paxillin in breast tumor cell invasion.
[Molecular Biology of the Cell]
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The Tale of TILs in Breast Cancer: A Report from the International Immuno-Oncology Biomarker Working Group

The authors discuss the biological understanding of tumor-infiltrating lymphocytes (TILs), their analytical and clinical validity and efforts towards the clinical utility in breast cancer, and the current status of programmed death-ligand 1and TIL testing across different continents.
[npj Breast Cancer]
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Breast Cancer Vaccines for Treatment and Prevention

Breast cancer is immunogenic and a variety of vaccines have been designed to boost immunity directed against the disease. Newer approaches are designing vaccines to prevent breast cancer by intercepting high-risk lesions such as ductal carcinoma in situ to limit the progression of these tumors to invasive cancer.
[Breast Cancer Research and Treatment]
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