Investigators demonstrated that LAS1 like ribosome biogenesis factor protein expression was significantly elevated in TNBC patients, and it functionally was important for mammary tumor growth in xenograft models and enabled invasive attributes.
[Cell Death & Disease]
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Weeks, S. E., Kammerud, S. C., Metge, B. J., AlSheikh, H. A., Schneider, D. A., Chen, D., Wei, S., Mobley, J. A., Ojesina, A. I., Shevde, L. A., & Samant, R. S. (2021). Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancer. Cell Death & Disease, 12(3), 1–13. https://doi.org/10.1038/s41419-021-03531-z Cite
In order to uncover metabolic pathways regulated by BCDIN3D in cancer, we performed an unbiased analysis of the metabolome, transcriptome, and proteome of breast cancer cells depleted for BCDIN3D.
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BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through let-7 microRNA in breast cancer cells | Oncogene. (n.d.). Retrieved March 4, 2021, from https://www.nature.com/articles/s41388-021-01702-y Cite
The authors analyzed miRNA expression within areas of TNBCs with cellular morphology that may be related to the epithelial to mesenchymal transition process and discuss possible associations.
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Koleckova, M., Ehrmann, J., Bouchal, J., Janikova, M., Brisudova, A., Srovnal, J., Staffova, K., Svoboda, M., Slaby, O., Radova, L., Vomackova, K., Melichar, B., Veverkova, L., & Kolar, Z. (2021). Epithelial to mesenchymal transition and microRNA expression are associated with spindle and apocrine cell morphology in triple-negative breast cancer. Scientific Reports, 11(1), 5145. https://doi.org/10.1038/s41598-021-84350-2 Cite
Allarity Therapeutics A/S announced that it has enrolled the first patient in its European Phase II clinical trial of IXEMPRA® for the treatment of metastatic breast cancer.
[Allarity Therapeutics A/S]
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Kintara Therapeutics, Inc.announced the appointment of Mario Lacouture, to the REM-001 Scientific Advisory Board with the initial focus in Cutaneous Metastatic Breast Cancer.
[Kintara Therapeutics, Inc.]
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The authors demonstrated the growth and metastasis inhibitory potential of nimbolide on TNBC cells. Nimbolide inhibited cell proliferation, migratory, and invasive abilities of TNBC cells and also changed the shape of MDA-MB-231 cells, which is correlated with cytoskeletal changes including actin depolymerization.
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Scientists discuss the breast tumor microbiota, its colonization by F. nucleatum, possible mechanisms by which F. nucleatum might promote breast cancer progression and how this might impact breast cancer treatment.
The authors demonstrated that, when the conjugated vesicles were loaded with the chemotherapeutic epirubicin, superior inhibition of TNBC cell growth was observed both in vitro and in vivo.
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De Vita, A., Liverani, C., Molinaro, R., Martinez, J. O., Hartman, K. A., Spadazzi, C., Miserocchi, G., Taraballi, F., Evangelopoulos, M., Pieri, F., Bongiovanni, A., Mercatali, L., Tasciotti, E., & Ibrahim, T. (2021). Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer. Scientific Reports, 11(1), 5107. https://doi.org/10.1038/s41598-021-84492-3 Cite
Scientists report that low levels of TAp73 correlated with an increased NF-κB–regulated inflammatory signature in breast cancer.
[Proceedings of the National Academy of Sciences of the United States of America]
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Wolfsberger, J., Sakil, H. A. M., Zhou, L., Bree, N. van, Baldisseri, E., Ferreira, S. de S., Zubillaga, V., Stantic, M., Fritz, N., Hartman, J., Rolny, C., & Wilhelm, M. T. (2021). TAp73 represses NF-κB–mediated recruitment of tumor-associated macrophages in breast cancer. Proceedings of the National Academy of Sciences, 118(10). https://doi.org/10.1073/pnas.2017089118 Cite
The authors revealed that SF3A3 protein levels predict molecular and phenotypic features of aggressive human breast cancers.
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Cieśla, M., Ngoc, P. C. T., Cordero, E., Martinez, Á. S., Morsing, M., Muthukumar, S., Beneventi, G., Madej, M., Munita, R., Jönsson, T., Lövgren, K., Ebbesson, A., Nodin, B., Hedenfalk, I., Jirström, K., Vallon-Christersson, J., Honeth, G., Staaf, J., Incarnato, D., … Bellodi, C. (2021). Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer. Molecular Cell, 0(0). https://doi.org/10.1016/j.molcel.2021.01.034 Cite
The authors investigated the possibility to predict BRCA1 promoter methylation status based on the morphological and immunohistochemical features of TNBCs.
[Journal of Human Genetics]
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