Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Breast Cancer Remotely Imposes a Myeloid Bias on Haematopoietic Stem Cells by Reprogramming the Bone Marrow Niche

[Nature Cell Biology] Using unbiased transcriptomic analysis and in situ imaging of HSCs and the bone marrow niche during breast cancer, researchers showed that both HSCs and mesenchymal stem cells were transcriptionally and spatially modified.

Triple-Negative Breast Cancer: A New Clinical Study Opens New and Promising Therapeutic Prospects.

[McGill University Health Centre] The Research Institute of the McGill University Health Centre will host a new Phase III randomized clinical trial called TROPION-Breast04, as announced by the McPeak-Sirois Group, a provincial consortium of cancer centres across Quebec focused on breast cancer research.

PSMD14 Stabilizes Estrogen Signaling and Facilitates Breast Cancer Progression via Deubiquitinating ERα

[Oncogene] The authors identified key deubiquitinases that significantly impact breast cancer progression and have important implications for breast cancer therapeutics.

SIX1 Amplification Modulates Stemness and Tumorigenesis in Breast Cancer

[Journal of Translational Medicine] Researchers demonstrated that the expression of Sine oculis homeobox homolog 1 (SIX1) varied among different subtypes of breast cancer and that it upregulated breast cancer grading and lymph node metastasis.

Key Regulator PNPLA8 Drives Phospholipid Reprogramming Induced Proliferation and Migration in Triple-Negative Breast Cancer

[Breast Cancer Research] Scientists highlighted patatin-like phospholipase domain-containing lipase 8 (PNPLA8) as key regulator of phospholipid metabolic reprogramming and malignant phenotypes in TNBC.

Biogenic Synthesis of Gold Nanoparticles Using Dual Extract of Tulsi–Vinca for Breast Cancer Tumor Regression in Mice

[Nanomedicine] Investigators synthesized the gold nanoparticles (GNPs) using a dual extract of tulsi and Vinca for breast cancer tumor regression. The GNPs were synthesized and characterized for their microscopic, spectroscopic, and crystalline properties.

Enhancer-Driven 3D Chromatin Domain Folding Modulates Transcription in Human Mammary Tumor Cells

[Life Science Alliance] Scientists determined chromatin folding and composition over several hundred kb around estrogen-responsive genes in human breast cancer cell lines after hormone stimulation.

WASF3 Overexpression Affects the Expression of Circular RNA Hsa-Circ-0100153, Which Promotes Breast Cancer Progression by Sponging Hsa-miR-31, Hsa-miR-767-3p, and Hsa-miR-935

[Heliyon] Scientists revealed a mechanism by which WASF3 overexpression affected the expression of circRNAs hsa-circ-0100153, promoting breast cancer progression by sponging hsa-miR-31/hsa-miR-767-3p /hsa-miR-935.

The Effect of Lactate Dehydrogenase Inhibitors on Proliferation, Motility and Invasion of Breast Cancer Cells In Vitro Highlights a New Role for Lactate

[Molecular Medicine Reports] Researchers determined the use of pharmacological lactate dehydrogenase (LDH) inhibitors to reduce aggressive behavior of breast cancer cells. The effect of LDH inhibitors was investigated in both estrogen receptor (ER)+ and ER breast cancer cell lines and in normal breast epithelial cells.

Bruceine A Inhibited Breast Cancer Proliferation and Metastasis by Inducing Autophagy via Targeting PI3K-AKT Signaling Pathway

[Chemical Biology & Drug Design] The authors found that, in addition to its cytotoxic effects, bruceine A significantly inhibited the invasion and migration capabilities of two types of breast cancer cell lines while concurrently promoting apoptosis in these cells.

The Role and Application of Vesicles in Triple-Negative Breast Cancer: Opportunities and Challenges

[Molecular Therapy Oncology] Scientists describe the roles of extracellular vesicles in tumor immune microenvironment, metabolic microenvironment and vascular remodeling.

1-Benzylimidazole Attenuates the Stemness of Breast Cancer Cells through Partially Targeting CYP4Z1

[Environmental Toxicology] RNA sequencing found that 1-benzylimidazole held a preferable correlation with breast cancer and suppressed the expression of CSC makers.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.