Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Cullin-5 Deficiency Orchestrates the Tumor Microenvironment to Promote Mammary Tumor Development through CREB1-CCL2 Signaling

[Science Advances] Scientists used both the sleeping beauty transposon mutagenesis system and CRISPR-Cas9–mediated genome-wide screening in mice to identify potential genetic alterations that acted synergistically with breast cancer–associated gene 1 deficiency to promote tumorignesis.

The Pseudokinase NRBP1 Activates Rac1/Cdc42 via P-Rex1 to Drive Oncogenic Signaling in Triple-Negative Breast Cancer

[Oncogene] Researchers determined that expression of the pseudokinase nuclear receptor binding protein 1 (NRBP1) positively associated with poor prognosis in TNBC and was required for efficient migration, invasion, and proliferation of TNBC cells in culture as well as growth of TNBC orthotopic xenografts and experimental metastasis.

Murine Breast Cancers Disorganize the Liver Transcriptome in a Zonated Manner

[Communications Biology] Using spatial transcriptomics, the authors investigated the abundance and zonation of hepatic genes in cancer-bearing mice. They found that breast cancers affected liver zonation in various distinct manners depending on biological pathways.

A Truncated and Catalytically Inactive Isoform of KDM5B Histone Demethylase Accumulates in Breast Cancer Cells and Regulates H3K4 Tri-Methylation and Gene Expression

[Cancer Gene Therapy] Researchers showed that histone lysine demethylase (KDM) 5B-N-terminal truncated, accumulated in breast cancer cell lines due to remarkable protein stability relative to the canonical PLU-1 isoform, which showed a much faster turnover.

Catechol-O-Methyl Transferase Suppresses Cell Invasion and Interplays with MET Signaling in Estrogen Dependent Breast Cancer

[Scientific Reports] To delineate catechol-O-methyl transferase (COMT) role in metastasis of estrogen receptor dependent breast cancer, scientists investigated the effect of COMT overexpression on invasion, transcriptome, proteome and interactome of MCF7 cells stably transduced with lentiviral vector carrying COMT gene.

Cyperotundone Combined with Adriamycin Induces Apoptosis in MCF-7 and MCF-7/ADR Cancer Cells by ROS Generation and NRF2/ARE Signaling Pathway

[Scientific Reports] Investigators found that adriamycin (ADR) + cyperotundone (CYT) inhibited the activity of MCF-7 and MCF-7/ADR cells in breast cancer, as well as causing apoptosis in MCF-7 and MCF-7/ADR cells and blocking the cell cycle in the G0/G1 phase.

Deregulation of miR-375 Inhibits HOXA5 and Promotes Migration, Invasion, and Cell Proliferation in Breast Cancer

[Applied Biochemistry and Biotechnology] Researchers explored the function of miR-375 in breast cancer. MicroRNA-375 targets were predicted by online target prediction tools and found that HOXA5 was one of the potential targets.

Eribulin Treatment Promotes Re-Expression of Estrogen Receptor in Endocrine Therapy-Resistant Hormone Receptor-Positive Breast Cancer Cells

[Anticancer Research] Scientists established hypoxia-resistant breast cancer cell lines by continuous culture in a hypoxic environment and investigated the effect of eribulin on hormone receptor-positive breast cancer cells that were resistant to endocrine blockade.

Metaplastic Breast Cancer: A Review

[Critical Reviews in Oncology/Hematology] The authors synthesize the existing data on the clinical, pathological and genomic features, management, and outcomes of metaplastic breast cancer. They also identify potential targets for future clinical trials.

Scientists behind Breast Cancer Gene Discovery Honored with New Plaques

[The Institute of Cancer Research] The team of 41 scientists who made a ground-breaking gene discovery of the BRCA2 cancer gene in 1995, transforming the field of cancer research, have been celebrated with the unveiling of two commemorative plaques in London.

Tetrandrine Inhibits Cancer Stem Cell Characteristics and Epithelial to Mesenchymal Transition in Triple-Negative Breast Cancer via SOD1/ROS Signaling Pathway

[American Journal Of Chinese Medicine] The effects of tetrandrine on cell growth, cell viability, cell stemness capacity, cell migration, and cell invasion, as well as the molecules involved in these processes, were investigated in a cell culture system.

HER2-Driven Breast Cancer Suppression by the JNK Signaling Pathway

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers reported that in vitro studies of human mammary epithelial cells with CRISPR-induced mutations in the MAPK and MAP2K components of the JNK pathway caused no change in growth in two-dimensional culture, but these mutations promoted epithelial cell proliferation in three-dimensional culture.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.