Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Systemic and Local Chronic Inflammation and Hormone Disposition Promote a Tumor-Permissive Environment for Breast Cancer in Older Women

August 6, 2026

[Nature Aging] Researchers examined how age-associated systemic changes relate to alterations in the local breast tumor microenvironment (TME), with a focus on hormone signaling and inflammation. They identified age-related differences in estrogen disposition and inflammatory profiles that are associated with features of an immunologically altered tumor microenvironment.

BCRF Announces $1.5 Million Grant to Support Team ATLAS, a Global Effort to Learn Why Some People Never Develop Cancer

August 6, 2026

[BCRF ] The Breast Cancer Research Foundation (BCRF) announced a $1.5 million grant over five years to support Team ATLAS, an international research collaboration exploring why some people remain breast cancer-free despite age, inherited risk, environmental exposures, or other known risk factors.

Dynamics, Function, and Regulation of Mammary Stem Cells in Development, and Disease

August 6, 2026

[Experimental & Molecular Medicine] The close parallels between mammary stem cells and tumor-initiating cells, particularly their shared plasticity and self-renewal, highlight stemness as a central node linking developmental programs to malignant transformation.

HER2 Heterogeneous Breast Cancer Models Reveal Novel Therapeutic Targets and Subclonal Dynamics during Evolution to Resistance to HER2-Targeted Therapies

August 6, 2026

[Cancer Discovery] Investigators described human HER2 HET breast cancer models composed of ERBB2-amplified (HER2hi) and nonamplified (HER2lo) cell populations derived from the same tumor. Utilizing these models, together with cellular barcoding, they demonstrated subclonal cooperation between HER2hi and HER2lo subpopulations.

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple-Negative Breast Cancer Progression

August 6, 2026

[Advanced Science] Scientists identified endothelin receptor type A (EDNRA) as a druggable G protein-coupled receptor associated with sustained Hippo/YAP activation and aggressive TNBC phenotypes.

HRC Grants $1 Million Plus to Health Researchers with Innovative Ideas

August 6, 2026

[University of Auckland] Seven research projects offering innovative ideas to achieve better outcomes for a range of health issues including breast cancer, HIV transmission and autoimmune disease have been awarded a total of just over $1 million in the Health Research Council's Explorer grant.

A Chromatin-Informed Transcriptional Regulatory Framework to Stratify Patients and Guide Therapy Selection in Triple-Negative Breast Cancer

August 6, 2026

[Nature Communications] Researchers integrated transcriptional regulatory network inference with chromatin accessibility across a large-scale multi-system collection of primary tumors, patient-derived xenografts and model cell lines to quantify transcription factor activity and identify regulators that underpin TNBC identity.

PBRM1-Dependent PBAF Targeting Is Required for EMT and Metastasis in Breast Cancer

August 6, 2026

[Science Advances] Researchers showed that the PBRM1 subunit of PBAF is critical for the completion of TGFβ1-mediated epithelial-mesenchymal transition (EMT) of mammary cells in vitro as well as the metastasis of murine breast cancers in vivo.

Biomarker-Guided Responses in Patient-Derived Organoids Predict Effective Therapies in Breast Cancer

August 6, 2026

[Cell Reports Medicine] Investigators presented a biomarker-guided characterization of 40 patient-derived breast cancer organoids, with the aim of modeling resistant disease with greater fidelity and developing an in vitro system grounded in clinical data for testing alternative treatment strategies.

UToledo Researcher Tackles Drug Resistance in Aggressive Breast Cancer

July 24, 2026

[University of Toledo] A University of Toledo researcher has received a grant from the National Cancer Institute of the National Institutes of Health to investigate a new strategy for overcoming one of the most stubborn obstacles in treating TNBC: resistance to chemotherapy.

Spatial Ecology of Breast Cancer Reveals Co-Evolution of Proliferative and Dormant Niches

July 24, 2026

[Genome Medicine] Investigators leveraged single-cell and spatially profiled primary breast tumours to quantify G0 arrest and proliferation decisions in cancer cells, revealing molecular and spatial features associated with proliferation-G0 dynamics.

Carrier-Free Nanoparticles Enhance Photothermal-Immune Therapy via Metabolic Reprogramming in Triple-Negative Breast Cancer

July 24, 2026

[Advanced Healthcare Materials] Scientists developed a carrier-free co-assembled nanoplatform, designated as IR@PF-M NPs, to enhance photothermal-immunotherapy against TNBC by reprogramming methionine metabolism.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.