Ipatasertib plus Paclitaxel for Patients with PIK3CA/AKT1/PTEN-Altered Locally Advanced Unresectable or Metastatic Triple-Negative Breast Cancer in the IPATunity130 Phase III Trial

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In the randomized Phase II LOTUS trial, combining ipatasertib with first-line paclitaxel for TNBC improved progression-free survival, particularly in patients with PIK3CA/AKT1/PTEN-altered tumors.
[Clinical Cancer Research]
Abstract