Integrated Diagnosis Based on Transcriptome Analysis in Suspected Pediatric Sarcomas

To evaluate the potential utility of including RNA-sequencing in the diagnostic process, investigators performed RNA-sequencing in 47 patients with suspected pediatric sarcomas.
[npj Genomic Medicine]
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B2M Gene Expression Shapes the Immune Landscape of Lung Adenocarcinoma and Determines the Response to Immunotherapy

Scientists performed an integrative analysis of the mutational and transcriptional profiles of large cohorts of non-small-cell lung cancer patients and found that epigenetic downregulation of B2M was common.
[Immunology]
Zhao, Y., Cao, Y., Chen, Y., Wu, L., Hang, H., Jiang, C., & Zhou, X. (n.d.). B2M gene expression shapes the immune landscape of lung adenocarcinoma and determines the response to immunotherapy. Immunology, n/a(n/a). https://doi.org/10.1111/imm.13384 Cite
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A Chondrosphere-Based Scaffold Free Approach to Manufacture an In Vitro Articular Cartilage Model

Human articular chondrocytes and immortalised mesenchymal cells differentiated in chondrocytes were cultured in round-bottom 96-well plates to produce multicellular spheroids and their growth kinetics and viability was evaluated over seven days of culture.
[Tissue Engineering Part A]
Scalzone, A., Wang, X. N., Dalgarno, K., Ferreira-Duarte, A. M., & Gentile, P. (2021). A chondrosphere-based scaffold free approach to manufacture an in-vitro articular cartilage model. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2021.0061 Cite
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Human Endometrium-Derived Stem Cell Improves Cardiac Function after Myocardial Ischemic Injury by Enhancing Angiogenesis and Myocardial Metabolism

Investigators investigated whether human endometrium-derived stem cells could be used for cardiac repair after ischemic injury and their possible underlying mechanisms.
[Current Stem Cell Research & Therapy]
Fan, X., He, S., Song, H., Yin, W., Zhang, J., Peng, Z., Yang, K., Zhai, X., Zhao, L., Gong, H., Ping, Y., Jiao, X., Zhang, S., Yan, C., Wang, H., Li, R.-K., & Xie, J. (2021). Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism. Stem Cell Research & Therapy, 12(1), 344. https://doi.org/10.1186/s13287-021-02423-5 Cite
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Blocking Siglec-10hi Tumor-Associated Macrophages Improves Anti-Tumor Immunity and Enhances Immunotherapy for Hepatocellular Carcinoma

Immunohistochemistry and flow cytometry were performed to detect the characteristics of sialic acid-binding immunoglobulin-like lectin 10high (Siglec-10hi) tumor-associated macrophages and explore their impact on the tumor microenvironment of hepatocellular carcinoma.
[Experimental Hematology & Oncology]
Xiao, N., Zhu, X., Li, K., Chen, Y., Liu, X., Xu, B., Lei, M., Xu, J., & Sun, H.-C. (2021). Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma. Experimental Hematology & Oncology, 10(1), 36. https://doi.org/10.1186/s40164-021-00230-5 Cite
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Imaging CAR T-Cell Kinetics in Solid Tumors: Translational Implications

Scientists conducted dual tumor and T-cell imaging by use of a bioluminescent reporter and positron emission tomography in clinically relevant mouse models of pleural mesothelioma and non-small cell lung cancer.
[Molecular Therapy-Oncolytics]
Skovgard, M. S., Hocine, H. R., Saini, J. K., Moroz, M., Bellis, R. Y., Banerjee, S., Morello, A., Ponomarev, V., Villena-Vargas, J., & Adusumilli, P. S. (2021). Imaging CAR T-Cell Kinetics in Solid Tumors: Translational Implications. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.06.006 Cite
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Immune Modulation via Adipose Derived Mesenchymal Stem Cells Is Driven by Donor Sex In Vitro

The authors examined the potency and functionality of both female and male adipose derived mesenchymal stem cells in order to gain further insights into donor selection.
[Scientific Reports]
Mckinnirey, F., Herbert, B., Vesey, G., & McCracken, S. (2021). Immune modulation via adipose derived Mesenchymal Stem cells is driven by donor sex in vitro. Scientific Reports, 11(1), 12454. https://doi.org/10.1038/s41598-021-91870-4 Cite
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Human Kidney Spheroids and Monolayers Provide Insights into SARS-CoV-2 Renal Interactions

Using ex vivo cell models, investigators analyzed SARS-Cov2 interactions with kidney tubular cells and assessed direct tubular injury. These models comprised primary human kidney epithelial cells and more quiescent three-dimensional kidney spheroids.
[Clinical Journal of the American Society of Nephrology]
Omer, D., Pleniceanu, O., Gnatek, Y., Namestnikov, M., Cohen-Zontag, O., Goldberg, S., Friedman, Y. E., Friedman, N., Mandelboim, M., Vitner, E., Achdout, H., Avraham, R., Zahavy, E., Israely, T., Mayan, H., & Dekel, B. (2021). Human Kidney Spheroids and Monolayers Provide Insights into SARS-CoV-2 Renal Interactions. Journal of the American Society of Nephrology. https://doi.org/10.1681/ASN.2020111546 Cite
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Extension of Retinofugal Projections in an Assembled Model of Human Pluripotent Stem Cell-Derived Organoids

Retinal organoids were generated and organized into an in vitro assembloid model of the visual system with cortical and thalamic organoids.
[Stem Cell Reports]
Fligor, C. M., Lavekar, S. S., Harkin, J., Shields, P. K., VanderWall, K. B., Huang, K.-C., Gomes, C., & Meyer, J. S. (2021). Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.05.009 Cite
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Fungal Brain Infection Modeled in a Human-Neurovascular-Unit-on-a-Chip with a Functional Blood-Brain Barrier

Scientists showed that the neurotropism of Cryptococcus neoformans and its ability to penetrate the blood-brain barrier (BBB) could be modeled by the co-culture of human neural stem cells, brain microvascular endothelial cells and brain vascular pericytes in a human-neurovascular-unit-on-a-chip maintained by a stepwise gravity-driven unidirectional flow and recapitulating the structural and functional features of the BBB.
[Nature Biomedical Engineering]
Kim, J., Lee, K.-T., Lee, J. S., Shin, J., Cui, B., Yang, K., Choi, Y. S., Choi, N., Lee, S. H., Lee, J.-H., Bahn, Y.-S., & Cho, S.-W. (2021). Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier. Nature Biomedical Engineering, 1–17. https://doi.org/10.1038/s41551-021-00743-8 Cite
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Single and Double Modified Salinomycin Analogs Target Stem-Like Cells in 2D and 3D Breast Cancer Models

A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast cancer stem cells.
[Biomedicine & Pharmacotherapy]
Urbaniak, A., Reed, M. R., Fil, D., Moorjani, A., Heflin, S., Antoszczak, M., Sulik, M., Huczyński, A., Kupsik, M., Eoff, R. L., MacNicol, M. C., Chambers, T. C., & MacNicol, A. M. (2021). Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models. Biomedicine & Pharmacotherapy, 141, 111815. https://doi.org/10.1016/j.biopha.2021.111815 Cite
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