Researchers investigated whether sulforaphane could enhance the chemotherapeutic effects of cisplatin and 5-fluorouracil against head and neck squamous cell carcinomas–cancer stem cells, and its mechanisms of action.
[British Journal of Cancer]
Scientists report that the emergence of refractory phenotypes was highly associated with an aberrant macroautophagic/autophagic state of NANOG+ tumor cells and that the autophagic phenotype arises through transcriptional induction of MAP1LC3B/LC3B by NANOG.
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Kim, S., Cho, H., Hong, S.-O., Oh, S. J., Lee, H.-J., Cho, E., Woo, S. R., Song, J. S., Chung, J.-Y., Son, S. W., Yoon, S. M., Jeon, Y.-M., Jeon, S., Yee, C., Lee, K.-M., Hewitt, S. M., Kim, J.-H., Song, K.-H., & Kim, T. W. (2020). LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1805214 Cite
Researchers showed that myelodysplastic NUP98‑HOXD13 transgenic mice displayed an abnormally high number of osteoblasts, yet a higher fraction of nonmineralized bone, indicating delayed bone mineralization. This was accompanied by high fibroblast growth factor-23 serum levels, a phosphaturic hormone that inhibits bone mineralization and erythropoiesis.
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Weidner, H., Baschant, U., Lademann, F., Colunga, M. G. L., Balaian, E., Hofbauer, C., Misof, B. M., Roschger, P., Blouin, S., Richards, W. G., Platzbecker, U., Hofbauer, L. C., & Rauner, M. (2020). Increased FGF-23 levels are linked to ineffective erythropoiesis and impaired bone mineralization in myelodysplastic syndromes. JCI Insight, 5(15). https://doi.org/10.1172/jci.insight.137062 Cite
Investigators determined the effect of alcohol exposure on sonic hedgehog signaling in the regulation of hematopoietic stem cell activation during bacteremia.
[Alcoholism-Clinical and Experimental Research]
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Shi, X., Simms, K. J., & Zhang, P. (n.d.). Acute Alcohol Intoxication Impairs SHH-Gli1 Signaling and Activation of Primitive Hematopoietic Precursor Cells in the Early Stage of Host Response to Bacteremia. Alcoholism: Clinical and Experimental Research, n/a(n/a). https://doi.org/10.1111/acer.14429 Cite
To investigate the effects of human umbilical cord mesenchymal stem cell (HUCMSC) delivery on the acute inflammatory stage of ischemia reperfusion injury, the authors transplanted HUCMSCs or HUCMSCs with cyclosporin A via the coronary artery simultaneously during ischemia reperfusion in pigs.
[Stem Cells and Development]
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Liu, C., Kang, L.-N., Chen, F., Mu, D., Shen, S., Wang, K., Hu, J.-X., Xie, J., & Xu, B. (2020). Immediate intracoronary delivery of human umbilical cord mesenchymal stem cells reduces myocardial injury by regulating the inflammatory process via cell-cell contact with T lymphocytes. Stem Cells and Development. https://doi.org/10.1089/scd.2019.0264 Cite
Continue reading “Immediate Intracoronary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Reduces Myocardial Injury by Regulating the Inflammatory Process via Cell-Cell Contact with T Lymphocytes”
Elevated never in mitosis gene A-related kinase 2 level promoted the rapid cell cycle progression and favors the rapid proliferation of epidermal growth factor receptor-mutant non-small cell lung cancer cells.
[Molecular and Cellular Biochemistry]
Scientists developed a lactate‐dependent cell proliferation assay and found that dynamin‐related protein (DRP1), which was highly expressed in KRAS‐mutant non‐small cell lung cancer (NSCLC), was required for tumor cells to proliferate and uses lactate as fuel, demonstrating the critical role of DRP1 in the metabolic reprogramming of NSCLC.
Using a multidisciplinary approach that combines clonal analysis with quantitative modelling and single-cell RNA sequencing, scientists showed that stretching induced skin expansion by creating a transient bias in the renewal activity of epidermal stem cells, while a second subpopulation of basal progenitors remained committed to differentiation.
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Aragona, M., Sifrim, A., Malfait, M., Song, Y., Van Herck, J., Dekoninck, S., Gargouri, S., Lapouge, G., Swedlund, B., Dubois, C., Baatsen, P., Vints, K., Han, S., Tissir, F., Voet, T., Simons, B. D., & Blanpain, C. (2020). Mechanisms of stretch-mediated skin expansion at single-cell resolution. Nature, 1–6. https://doi.org/10.1038/s41586-020-2555-7 Cite
Scientists found that circ-GLI1 exacerbated the metastasis and angiogenesis of melanoma by upregulating Cyr61 via p70S6K2-dependent activation of Hedgehog/GLI1 and Wnt/β-catenin pathways.
[Cell Death & Disease]
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Chen, J., Zhou, X., Yang, J., Sun, Q., Liu, Y., Li, N., Zhang, Z., & Xu, H. (2020). Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61. Cell Death & Disease, 11(7), 1–16. https://doi.org/10.1038/s41419-020-02799-x Cite
Real-time cellular analysis showed that depending on the keratinocyte differentiation state, the applied C. acnes strains and their dose, the measured impedance values change, together with the expression of selected tight junction proteins.
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Using complementary fate-mapping approaches, researchers showed that hair follicle mesenchymal progenitors made limited contributions to wound repair. In contrast, extrafollicular progenitors marked by the quiescence-associated factor Hic1 generated the bulk of reparative fibroblasts and exhibited functional divergence, mediating regeneration in the center of the wound neodermis and scar formation in the periphery.
[Cell Stem Cell]
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Abbasi, S., Sinha, S., Labit, E., Rosin, N. L., Yoon, G., Rahmani, W., Jaffer, A., Sharma, N., Hagner, A., Shah, P., Arora, R., Yoon, J., Islam, A., Uchida, A., Chang, C. K., Stratton, J. A., Scott, R. W., Rossi, F. M. V., Underhill, T. M., & Biernaskie, J. (2020). Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.07.008 Cite
Dynamic control of tumor vessels in C57BL/6 mice bearing B16 melanoma was performed using volume expansion followed by phenylephrine. Intravital microscopy was used to observe changes directly in real time.
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Gabriel, E. M., Kim, M., Fisher, D. T., Powers, C., Attwood, K., Bagaria, S. P., Knutson, K. L., & Skitzki, J. J. (2020). Dynamic control of tumor vasculature improves antitumor responses in a regional model of melanoma. Scientific Reports, 10(1), 13245. https://doi.org/10.1038/s41598-020-70233-5 Cite