Publication

[Molecular Cancer] The impact of circPIAS1-108aa on the ferroptosis process of melanoma cells was studied through glutathione, malondialdehyde, and C11-BODIPY staining assays. Proliferation changes in melanoma cells were assessed using cell counting Kit-8, EdU, and colony formation assays.

[Journal of Experimental & Clinical Cancer Research] CRISRPcas9 was used to knock out IRF1 and IRF2 genes in human and mouse melanoma cells and the resulting phenotypes were analyzed in vitro and in vivo.

[Journal For Immunotherapy of Cancer] Researchers investigated the binding between PD-1, pembrolizumab, and galectin-3 (Gal-3) by surface plasmon resonance and cryogenic electron microscopy. The function was studied in in vitro cultures and soluble levels of both PD-1 and Gal-3 were measured in metastatic melanoma patients, treated with pembrolizumab.

[Cell Death & Disease] Scientists discovered that lipid peroxidation promoted the formation of lipid rafts in the membrane, which mediated by acyl-coA synthetase long chain family member 4 (ACSL4) impaired the sensitivity of melanoma cells to platinum-based drugs.

[ACS Nano] Nanofibrous microspheres (NMs) demonstrated enhanced cell adhesion to human dermal fibroblasts during an in vitro cytocompatibility assessment. Additionally, NMs promoted host cell infiltration, neovascularization, and re-epithelialization in a diabetic mouse wound model.

[NPJ Regenerative Medicine] Genetic and pharmacological inhibitions of NOX2 in macrophages and bioengineered skin infected with Staphylococcus aureus and treated with cold atmospheric plasma reduced intracellular oxidants and increased bacterial survival.