Publication

[Nature Communications] Scientists identified the stress kinase p38β (MAPK11) supports tumor-initiating cell maintenance and drug resistance in hepatocellular carcinoma (HCC). Integrated analysis of chemotherapy-enriched HCC spheroids, and DepMap data prioritized p38β as a kinase linked to stemness and chemoresistance.

[Advanced Science] Researchers identifeid WD repeat domain 72 (WDR72) as a cancer stem cell marker that significantly correlates with high-risk of neuroblastoma and poor prognosis in neuroblastoma patients.

[Nature Cell Biology] Investigators used a fluorescent reporter that marks CSCs to show that CSCs and their more differentiated progeny display strikingly different population dynamics during metastatic lung colonization in breast cancer models.

[Acta Pharmacologica Sinica] Using triple negative breast cancer cell lines (TNBC) and CSCs enriched from these cell lines scientists revealed that the PD-1/PD-L1 pathway predominantly mediates CSC-driven immune evasion, growth, and metastasis in TNBC.

[Oncogene] Researchers identified the histone methyltransferase KMT5C as master regulator of hepatocellular carcinoma stemness and progression through integrative analyses of patient-derived organoids, murine models, and clinical cohorts.

[Journal of Advanced Research] Lineage tracing experiments revealed that Hopx+ quiescent stem cell subpopulation exhibited an enhanced regeneration, which functionally drove the recurrence of rectal cancer after irradiation.