Publication

[Nature] Investigators showed that exogenous serine-dependent pancreatic ductal adenocarcinoma cells reprogram neighbouring hepatocytes through a CXCL5–CXCR2 axis.

[Journal of Hepatology] Scientists aimed to investigate the systemic factors and cellular mechanisms that promote aged liver regeneration, highlighting the therapeutic potential of lymphotoxin β-based strategies to increase regeneration in aging populations.

[Gut] Researchers investigated whether butyrylcholinesterase (BuChE) regulates fibrosis by modulating acetylcholine bioavailability and identified downstream cholinergic signalling, observing increased hepatic stellate cell activation and fibrosis upon hepatocyte BuChE deletion or inhibition.

[Nature Biomedical Engineering] Investigators showed that in hepatitis B virus (HBV) mouse models, a single dose of CRMA-1001, which employs an optimized epigenetic silencer that represses viral transcription, produced >3-log10 reductions in viral biomarkers, which correlated with de novo methylation of HBV DNA.

[Cell Death & Disease] The authors found that copper-provoked iron vulnerability is not driven by Fenton chemistry-driven ROS damage, but instead induces a cuproptotic-like mechanism, characterized by proteotoxic stress, loss of iron-sulfur cluster enzyme activity, and severe mitochondrial dysfunction in hereditary hemochromatosis.

[EMBO Reports] Scientists identified VGLL4 as a positive regulator of metabolic dysfunction-associated fatty liver disease progression.