Publication

[Nature] In mice, IL-33 deficiency severely attenuated inflammation- and lymphotoxin (LT)–LTβ receptor-activation-induced tertiary lymphoid structures in models of colitis and PDAC.

[Scientific Reports] Through transcriptomic and single-cell RNA sequencing analyses, researchers explored metabolic pathway enrichment, immune infiltration patterns, and differential gene expression in prostate cancer samples.

[Stem Cell Reports] Scientists isolated and characterized guinea pig epiblast stem cells from post-implantation embryos. These cells differentiated into the three germ layers, maintained normal karyotypes, and relied on FGF2 and ACTIVIN A signaling for self-renewal and pluripotency.

[Small] The Under-oil Open Microfluidic System microtumor model – allowing a controlled but also self-organized, cell-directed tumor-ECM microenvironment in an open microfluidic configuration – was used to test an anti-metastasis drug with a triple-negative breast cancer cell line.

[Proceedings of The National Academy of Sciences of The United States of America] Scientists investigated the role of ADARp110 in hepatocellular carcinoma and underlying mechanisms using clinical samples, a hepatocyte-specific Adarp110 knock-in mouse model, and engineered cell lines.

[Communications Biology] The authors found that PLAC8 was downregulated in the lungs of idopathic pulmonary fibrosis patients, in bleomycin-induced lungs of mice, and in primary murine alveolar epithelial type II cells and human lung epithelial cell A549 cells.