Breast Tumor Cells Promotes the Horizontal Propagation of EMT, Stemness, and Metastasis by Transferring the MAP17 Protein Between Subsets of Neoplastic Cells

Scientists explored the role of MAP17 protein shaping tumor evolution and showed that in breast cancer, cells increased MAP17 levels in tumors by demethylation induced multiple changes in gene expression through specific miRNAs downregulation.
[Oncogenesis]
García-Heredia, J. M., Otero-Albiol, D., Pérez, M., Pérez-Castejón, E., Muñoz-Galván, S., & Carnero, A. (2020). Breast tumor cells promotes the horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein between subsets of neoplastic cells. Oncogenesis, 9(10), 1–16. https://doi.org/10.1038/s41389-020-00280-0 Cite
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MicroRNA-488 Inhibits Proliferation and Motility of Tumor Cells via Downregulating FSCN1, Modulated by Notch3 in Breast Carcinomas

The authors investigated the function of a new tumor suppressor microRNA, miR-488, and its molecular mechanism of metastasis in breast cancers.
[Cell Death & Disease]
Wu, Y., Yuan, M.-H., Wu, H.-T., Chen, W.-J., Zhang, M.-L., Ye, Q.-Q., Liu, J., & Zhang, G.-J. (2020). MicroRNA-488 inhibits proliferation and motility of tumor cells via downregulating FSCN1, modulated by Notch3 in breast carcinomas. Cell Death & Disease, 11(10), 1–13. https://doi.org/10.1038/s41419-020-03121-5 Cite
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Stimulation of Neural Stem Cell Differentiation by Circularly Polarized Light Transduced by Chiral Nanoassemblies

Researchers showed that the differentiation of neural stem cells into neurons could be accelerated by circularly polarized photons when DNA-bridged chiral assemblies of gold nanoparticles were entangled with the cells’ cytoskeletal fibres.
[Nature Biomedical Engineering]
Qu, A., Sun, M., Kim, J.-Y., Xu, L., Hao, C., Ma, W., Wu, X., Liu, X., Kuang, H., Kotov, N. A., & Xu, C. (2020). Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies. Nature Biomedical Engineering, 1–11. https://doi.org/10.1038/s41551-020-00634-4 Cite
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Inhibition of MUC1 Exerts Cell-Cycle Arrest and Telomerase Suppression in Glioblastoma Cells

The anticancer mechanism of MUC1 suppression in glioblastoma was investigated. The expression level of MUC1 was analyzed in human glioma and paired normal brain tissues.
[Scientific Reports]
Kim, S., Seo, Y., Chowdhury, T., Yu, H. J., Lee, C. E., Kim, K.-M., Kang, H., Kim, H. J., Park, S.-J., Kim, K., & Park, C.-K. (2020). Inhibition of MUC1 exerts cell-cycle arrest and telomerase suppression in glioblastoma cells. Scientific Reports, 10(1), 18238. https://doi.org/10.1038/s41598-020-75457-z Cite
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Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia

The authors found that, in injured optic nerves, oligodendrocyte precursor cells undergone transient proliferation but failed to differentiate into mature myelination-competent oligodendrocytes, reminiscent of what was observed in human progressive multiple sclerosis.
[Neuron]
Wang, J., He, X., Meng, H., Li, Y., Dmitriev, P., Tian, F., Page, J. C., Lu, Q. R., & He, Z. (2020). Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia. Neuron, 0(0). https://doi.org/10.1016/j.neuron.2020.09.016 Cite
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The Odorant Receptor OR2W3 on Airway Smooth Muscle Evokes Bronchodilation via a Cooperative Chemosensory Tradeoff between TMEM16A and CFTR

Investigators characterized the effects of a wide range of volatile odorants on the contractile state of airway smooth muscle (ASM) and uncovered a complex mechanism of odorant-evoked signaling properties that regulate excitation-contraction coupling in human ASM cells.
[Proceedings of the National Academy of Sciences of the United States of America]
Huang, J., Lam, H., Koziol-White, C., Limjunyawong, N., Kim, D., Kim, N., Karmacharya, N., Rajkumar, P., Firer, D., Dalesio, N. M., Jude, J., Kurten, R. C., Pluznick, J. L., Deshpande, D. A., Penn, R. B., Liggett, S. B., Panettieri, R. A., Dong, X., & An, S. S. (2020). The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2003111117 Cite
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Myocardial Infarction Affects Cx43 Content of Extracellular Vesicles Secreted by Cardiomyocytes

Using a comprehensive strategy that included cell-based approaches, animal models and human patients, scientists demonstrated that myocardial ischemia impairs the secretion of Cx43 into circulating, intracardiac and cardiomyocyte-derived vesicles.
[Life Science Alliance]
Martins-Marques, T., Ribeiro-Rodrigues, T., Jager, S. C. de, Zuzarte, M., Ferreira, C., Cruz, P., Reis, L., Baptista, R., Gonçalves, L., Sluijter, J. P., & Girao, H. (2020). Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes. Life Science Alliance, 3(12). https://doi.org/10.26508/lsa.202000821 Cite
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Substrate Utilization of Cultured Skeletal Muscle Cells in Patients with CFS

The authors outline experiments looking at the utilization of different substrates by skeletal muscle cells from chronic fatigue syndrome patients and healthy controls using extracellular flux analysis.
[Scientific Reports]
Tomas, C., Elson, J. L., Newton, J. L., & Walker, M. (2020). Substrate utilisation of cultured skeletal muscle cells in patients with CFS. Scientific Reports, 10(1), 18232. https://doi.org/10.1038/s41598-020-75406-w Cite
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Mitochondrial Pyruvate Carrier Abundance Mediates Pathological Cardiac Hypertrophy

Researchers showed that mitochondrial pyruvate carrier (MPC) abundance mediates pathological cardiac hypertrophy. MPC abundance was reduced in failing hypertrophic human hearts, as well as in the myocardium of mice induced to fail by angiotensin II or through transverse aortic constriction.
[Nature Metabolism]
Fernandez-Caggiano, M., Kamynina, A., Francois, A. A., Prysyazhna, O., Eykyn, T. R., Krasemann, S., Crespo-Leiro, M. G., Vieites, M. G., Bianchi, K., Morales, V., Domenech, N., & Eaton, P. (2020). Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy. Nature Metabolism, 1–9. https://doi.org/10.1038/s42255-020-00276-5 Cite
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FoxO Maintains a Genuine Muscle Stem-Cell Quiescent State until Geriatric Age

In homeostatic skeletal muscle, scientists identified two quiescent stem-cell states distinguished by relative CD34 expression: CD34High, with stemness properties, and CD34Low, committed to myogenic differentiation.
[Nature Cell Biology]
García-Prat, L., Perdiguero, E., Alonso-Martín, S., Dell’Orso, S., Ravichandran, S., Brooks, S. R., Juan, A. H., Campanario, S., Jiang, K., Hong, X., Ortet, L., Ruiz-Bonilla, V., Flández, M., Moiseeva, V., Rebollo, E., Jardí, M., Sun, H.-W., Musarò, A., Sandri, M., … Muñoz-Cánoves, P. (2020). FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age. Nature Cell Biology, 1–12. https://doi.org/10.1038/s41556-020-00593-7 Cite
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GDF11 Inhibits Cardiomyocyte Pyroptosis and Exerts Cardioprotection in Acute Myocardial Infarction Mice by Upregulation of Transcription Factor HOXA3

Researchers determined that growth differentiation factor 11 (GDF11) was abnormally downregulated in the heart tissue of myocardial infarction mice and hypoxic cardiomyocytes.
[Cell Death & Disease]
Li, Z., Xu, H., Liu, X., Hong, Y., Lou, H., Liu, H., Bai, X., Wang, L., Li, X., Monayo, S. M., Mokembo, J. N., Jha, N. K., Yang, B., & Zhang, Y. (2020). GDF11 inhibits cardiomyocyte pyroptosis and exerts cardioprotection in acute myocardial infarction mice by upregulation of transcription factor HOXA3. Cell Death & Disease, 11(10), 1–10. https://doi.org/10.1038/s41419-020-03120-6 Cite
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