2D Vanadium Carbide MXenzyme to Alleviate ROS-Mediated Inflammatory and Neurodegenerative Diseases

Based on the enzyme-mimicking properties, the constructed 2D vanadium carbide MXene nanoenzyme (MXenzyme) not only possessed high biocompatibility but also exhibited robust in vitro cytoprotection against oxidative stress.
[Nature Communications]
Feng, W., Han, X., Hu, H., Chang, M., Ding, L., Xiang, H., Chen, Y., & Li, Y. (2021). 2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases. Nature Communications, 12(1), 2203. https://doi.org/10.1038/s41467-021-22278-x Cite
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Cromolyn Inhibits the Secretion of Inflammatory Cytokines by Human Microglia (HMC3)

To better understand the mechanistic effect cromolyn has in slowing down or halting the neuroinflammatory response associated with Alzheimer’s Disease progression, the authors tested the effect of cromolyn to dampen the inflammatory response in the human HMC3 microglia cell line.
[Scientific Reports]
Wang, Y.-J., Monteagudo, A., Downey, M. A., Ashton-Rickardt, P. G., & Elmaleh, D. R. (2021). Cromolyn inhibits the secretion of inflammatory cytokines by human microglia (HMC3). Scientific Reports, 11(1), 8054. https://doi.org/10.1038/s41598-021-85702-8 Cite
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The Connectome of Neural Crest Enhancers Reveals Regulatory Features of Signaling Systems

To examine the role of long-range DNA interactions in early development, researchers generated a high-resolution contact map of active enhancers in avian neural crest cells.
[Developmental Cell]
Azambuja, A. P., & Simoes-Costa, M. (2021). The connectome of neural crest enhancers reveals regulatory features of signaling systems. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2021.03.024 Cite
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Brd4-Bound Enhancers Drive Cell-Intrinsic Sex Differences in Glioblastoma

Researchers discovered correlated transcriptome-wide sex differences in gene expression, H3K27ac marks, large Brd4-bound enhancer usage, and Brd4 localization to Myc and p53 genomic binding sites. These sex-biased gene expression patterns were also evident in human glioblastoma stem cells.
[Proceedings of the National Academy of Sciences of the United States of America]
Kfoury, N., Qi, Z., Prager, B. C., Wilkinson, M. N., Broestl, L., Berrett, K. C., Moudgil, A., Sankararaman, S., Chen, X., Gertz, J., Rich, J. N., Mitra, R. D., & Rubin, J. B. (2021). Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma. Proceedings of the National Academy of Sciences, 118(16). https://doi.org/10.1073/pnas.2017148118 Cite
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Integrated Transcription Factor Profiling with Transcriptome Analysis Identifies L1PA2 Transposons as Global Regulatory Modulators in a Breast Cancer Model

The authors applied the pipeline to a breast cancer model, and found that the L1PA2 transposon subfamily contributes abundant regulatory sequences to co-ordinated transcriptional regulation in breast cancer.
[Scientific Reports]
Jiang, J.-C., Rothnagel, J. A., & Upton, K. R. (2021). Integrated transcription factor profiling with transcriptome analysis identifies L1PA2 transposons as global regulatory modulators in a breast cancer model. Scientific Reports, 11(1), 8083. https://doi.org/10.1038/s41598-021-86395-9 Cite
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EFA6B Regulates a Stop Signal for Collective Invasion in Breast Cancer

Researchers report that loss of exchange factor for ARF6, B (EFA6B) triggered a transcriptional reprogramming of cell-to-ECM interaction machinery and unleashed CDC42-dependent collective invasion in collagen.
[Nature Communications]
Fayad, R., Rojas, M. V., Partisani, M., Finetti, P., Dib, S., Abelanet, S., Virolle, V., Farina, A., Cabaud, O., Lopez, M., Birnbaum, D., Bertucci, F., Franco, M., & Luton, F. (2021). EFA6B regulates a stop signal for collective invasion in breast cancer. Nature Communications, 12(1), 2198. https://doi.org/10.1038/s41467-021-22522-4 Cite
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Sex and Tamoxifen Confound Murine Experimental Studies in Cardiovascular Tissue Engineering

The authors describe the importance of challenging the baseline assumption that tamoxifen is inert when used as a small molecule inducer in the context of cardiovascular tissue engineering.
[Scientific Reports]
Blum, K. M., Roby, L. C., Zbinden, J. C., Chang, Y.-C., Mirhaidari, G. J. M., Reinhardt, J. W., Yi, T., Barker, J. C., & Breuer, C. K. (2021). Sex and Tamoxifen confound murine experimental studies in cardiovascular tissue engineering. Scientific Reports, 11(1), 8037. https://doi.org/10.1038/s41598-021-87006-3 Cite
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Exercise Training Improves Tumor Control by Increasing CD8+ T-Cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade

Scientists implanted E0771, EMT6, MMTV-PyMT, and MCa-M3C BC cells orthotopically in wild-type or Cxcr3-/- female mice and initiated intensity-controlled exercise training sessions when tumors reached ~100 mm3. They characterized the tumor microenvironment using flow cytometry, transcriptome analysis, proteome array, ELISA, and immunohistochemistry.
[Cancer Immunology Research]
Gomes-Santos, I. L., Amoozgar, Z., Kumar, A. S., Ho, W. W., Roh, K., Talele, N. P., Curtis, H., Kawaguchi, K., Jain, R. K., & Fukumura, D. (2021). Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0499 Cite
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Ferritinophagy Is Involved in the Zinc Oxide Nanoparticles-Induced Ferroptosis of Vascular Endothelial Cells

Scientists report that zinc oxide nanoparticles can induce ferroptosis of both HUVECs and EA.hy926 cells, as evidenced by the elevation of intracellular iron levels, lipid peroxidation and cell death in a dose- and time-dependent manner.
[Autophagy]
Qin, X., Zhang, J., Wang, B., Xu, G., Yang, X., Zou, Z., & Yu, C. (2021). Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells. Autophagy, 0(0), 1–20. https://doi.org/10.1080/15548627.2021.1911016 Cite
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Decline in IGF1 in the Bone Marrow Microenvironment Initiates Hematopoietic Stem Cell Aging

Scientists discover that hallmarks of aging in HSCs and hematopoiesis begin to accumulate by middle age and that the bone marrow microenvironment at middle age induced and was indispensable for hematopoietic aging.
[Cell Stem Cell]
Young, K., Eudy, E., Bell, R., Loberg, M. A., Stearns, T., Sharma, D., Velten, L., Haas, S., Filippi, M.-D., & Trowbridge, J. J. (2021). Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging. Cell Stem Cell. https://doi.org/10.1016/j.stem.2021.03.017 Cite
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P300/CBP Inhibition Sensitizes Mantle Cell Lymphoma to PI3Kδ Inhibitor Idelalisib

Scientists report that a p300/CBP inhibitor, A-485, could overcome resistance to idelalisib in mantle cell lymphoma cells in vitro and in vivo.
[Acta Pharmacologica Sinica]
Zhou, X., Li, X., Liao, L., Han, J., Huang, J., Li, J., Tao, H., Fan, S., Chen, Z., Li, Q., Chen, S., Ding, H., Yang, Y., Zhou, B., Jiang, H., Chen, K., Zhang, Y., Huang, C., & Luo, C. (2021). P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib. Acta Pharmacologica Sinica, 1–13. https://doi.org/10.1038/s41401-021-00643-2 Cite
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