AAV-Mediated Inhibition of ULK1 Promotes Axonal Regeneration in the Central Nervous System In Vitro and In Vivo

Scientists used an adeno-associated viral (AAV) vector to express a dominant-negative form of ULK1 and investigated its effects on axonal regeneration in the central nervous system.
[Cell Death & Disease]
Ribas, V. T., Vahsen, B. F., Tatenhorst, L., Estrada, V., Dambeck, V., Almeida, R. A., Bähr, M., Michel, U., Koch, J. C., Müller, H. W., & Lingor, P. (2021). AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo. Cell Death & Disease, 12(2), 1–18. https://doi.org/10.1038/s41419-021-03503-3 Cite
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LRP1 Mediates the IGF-1-Induced GLUT1 Expression on the Cell Surface and Glucose Uptake in Müller Glial Cells

The authors investigated whether Insulin-like Growth Factor-1 (IGF-1) modulates glucose transporter type 1 (GLUT1) traffic to plasma membrane (PM) and glucose uptake, as well as the involvement of Low-density lipoprotein Receptor-related Protein-1 (LRP1) in this process in the human Müller glial-derived cell line.
[Scientific Reports]
Actis Dato, V., Sánchez, M. C., & Chiabrando, G. A. (2021). LRP1 mediates the IGF-1-induced GLUT1 expression on the cell surface and glucose uptake in Müller glial cells. Scientific Reports, 11(1), 4742. https://doi.org/10.1038/s41598-021-84090-3 Cite
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Bardet-Biedl Syndrome Proteins Regulate Intracellular Signaling and Neuronal Function in Patient-Specific iPSC-Derived Neurons

Researchers developed a cellular model of Bardet-Biedl Syndrome using induced pluripotent stem cell (iPSCs)-derived hypothalamic arcuate-like neurons.
[Journal of Clinical Investigation]
Wang, L., Liu, Y., Stratigopoulos, G., Panigrahi, S. K., Sui, L., LeDuc, C. A., Glover, H. J., Rosa, M. C. D., Burnett, L. C., Williams, D. J., Shang, L., Goland, R., Tsang, S. H., Wardlaw, S. L., Egli, D., Zheng, D., Doege, C. A., & Leibel, R. L. (2021). Bardet-Biedl Syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI146287 Cite
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BKM120 Sensitizes BRCA-Proficient Triple Negative Breast Cancer Cells to Olaparib through Regulating FOXM1 and Exo1 Expression

Scientists found that dual phosphoinositide 3-kinase (PI3K) and poly (ADP-ribose) polymerase inhibition with BKM120 and olaparib significantly reduced the proliferation of BRCA-proficient TNBC cell lines.
[Scientific Reports]
Li, Y., Wang, Y., Zhang, W., Wang, X., Chen, L., & Wang, S. (2021). BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression. Scientific Reports, 11(1), 4774. https://doi.org/10.1038/s41598-021-82990-y Cite
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Mechanochemical Control of Epidermal Stem Cell Divisions by B-Plexins

Researchers identified a critical requirement of B-plexin transmembrane receptors in the response to crowding-induced mechanical forces during embryonic skin development.
[Nature Communications]
Jiang, C., Javed, A., Kaiser, L., Nava, M. M., Xu, R., Brandt, D. T., Zhao, D., Mayer, B., Fernández-Baldovinos, J., Zhou, L., Höß, C., Sawmynaden, K., Oleksy, A., Matthews, D., Weinstein, L. S., Hahn, H., Gröne, H.-J., Graumann, P. L., Niessen, C. M., … Worzfeld, T. (2021). Mechanochemical control of epidermal stem cell divisions by B-plexins. Nature Communications, 12(1), 1308. https://doi.org/10.1038/s41467-021-21513-9 Cite
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Functional Regeneration and Repair of Tendons Using Biomimetic Scaffolds Loaded with Recombinant Periostin

Investigators performed transcriptional profiling of tendon developmental processes to show that the extracellular matrix-associated protein periostin contributes to the maintenance of tendon stem/progenitor cell functions and promotes tendon regeneration.
[Nature Communications]
Wang, Y., Jin, S., Luo, D., He, D., Shi, C., Zhu, L., Guan, B., Li, Z., Zhang, T., Zhou, Y., Wang, C.-Y., & Liu, Y. (2021). Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin. Nature Communications, 12(1), 1293. https://doi.org/10.1038/s41467-021-21545-1 Cite
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(E)-N-(2-(3, 5-Dimethoxystyryl) Phenyl) Furan-2-Carboxamide (BK3C231) Induces Cytoprotection in CCD18-Co Human Colon Fibroblast Cells through Nrf2/ARE Pathway Activation

The authors investigated the molecular mechanisms underlying BK3C231-induced cytoprotection and the involvement of the Nrf2/ARE pathway.
[Scientific Reports]
Tan, H. H., Thomas, N. F., Inayat-Hussain, S. H., & Chan, K. M. (2021). (E)-N-(2-(3, 5-Dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) induces cytoprotection in CCD18-Co human colon fibroblast cells through Nrf2/ARE pathway activation. Scientific Reports, 11(1), 4773. https://doi.org/10.1038/s41598-021-83163-7 Cite
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Cholesterol Activates the Wnt/PCP-YAP Signaling in SOAT1-Targeted Treatment of Colon Cancer

Scientists demonstrated how targeting SOAT1 promotes YAP expression by elevating cellular cholesterol content in colon cancer cells.
[Cell Death Discovery]
Xu, H., Xia, H., Zhou, S., Tang, Q., & Bi, F. (2021). Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer. Cell Death Discovery, 7(1), 1–13. https://doi.org/10.1038/s41420-021-00421-3 Cite
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Exosomes Are Involved in Total Body Irradiation-Induced Intestinal Injury in Mice

Researchers investigated the roles of exosomes during total body irradiation-induced intestinal injury in vivo and in vitro.
[Acta Pharmacologica Sinica]
Li, H., Jiang, M., Zhao, S., Zhang, S., Lu, L., He, X., Feng, G., Wu, X., & Fan, S. (2021). Exosomes are involved in total body irradiation-induced intestinal injury in mice. Acta Pharmacologica Sinica, 1–13. https://doi.org/10.1038/s41401-021-00615-6 Cite
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The Protein Phosphatase PPM1A Dephosphorylates and Activates YAP to Govern Mammalian Intestinal and Liver Regeneration

Genetic ablation or depletion of PPM1A in cells, organoids, and mice elicited an enhanced Yes-associated protein (YAP)/TAZ cytoplasmic retention and resulted in the diminished cell proliferation, severe gut regeneration defects in colitis, and impeded liver regeneration upon injury.
[PLoS Biology]
Zhou, R., Wu, Q., Wang, M., Irani, S., Li, X., Zhang, Q., Meng, F., Liu, S., Zhang, F., Wu, L., Lin, X., Wang, X., Zou, J., Song, H., Qin, J., Liang, T., Feng, X.-H., Zhang, Y. J., & Xu, P. (2021). The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration. PLOS Biology, 19(2), e3001122. https://doi.org/10.1371/journal.pbio.3001122 Cite
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High Glucose Induces Drp1-Mediated Mitochondrial Fission via the Orai1 Calcium Channel to Participate in Diabetic Cardiomyocyte Hypertrophy

High glucose induced cardiomyocyte hypertrophy, accompanied by abnormal mitochondrial morphology and function, and increased Orai1-mediated Ca2+ influx.
[Cell Death & Disease]
Wu, Q.-R., Zheng, D.-L., Liu, P.-M., Yang, H., Li, L.-A., Kuang, S.-J., Lai, Y.-Y., Rao, F., Xue, Y.-M., Lin, J.-J., Liu, S.-X., Chen, C.-B., & Deng, C.-Y. (2021). High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy. Cell Death & Disease, 12(2), 1–15. https://doi.org/10.1038/s41419-021-03502-4 Cite
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