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Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling Pathway

[Research] Gradient rotating magnetic field exposure had a notable impact on the F-actin arrangement of MDA-MB-231, BT-549, and MDA-MB-468 cells, inhibiting cell migration and invasion.

LINC00460-FUS-MYC Feedback Loop Drives Breast Cancer Metastasis and Doxorubicin Resistance

[Oncogene] LINC00460 was demonstrated to promote stem cell-like and epithelial-mesenchymal transition characteristics in breast cancer cells.

Characterization of KIF20B as a Novel Prognostic Biomarker and Therapeutic Target for Breast Cancer

[International Journal of Oncology] Using reverse transcription‑quantitative PCR and western blotting, investigators discovered that kinesin family member 20B (KIF20B) mRNA and protein expression levels were upregulated in most breast cancer cell lines but were scarcely expressed in normal mammary epithelial cells.

Acetyl-CoA Carboxylase 1 Controls a Lipid Droplet–Peroxisome Axis and Is a Vulnerability of Endocrine-Resistant ER+ Breast Cancer

[Science Translational Medicine] Functional metabolic analysis revealed that lipid droplets together with peroxisomes, which researchers showed to be enriched and active in the long-term estrogen-deprived cells, controlled redox homeostasis and conferred metabolic adaptability to the resistant tumors.

Small Molecules That Disrupt RAD54-BLM Interaction Hamper Tumor Proliferation in Colon Cancer Chemoresistance Models

[Journal Of Clinical Investigation] Chromatin immunoprecipitation sequencing analysis and validation revealed increased BLM/RAD54 co-recruitment on MRP2 promoter in camptothecin resistant colon cancer cells, leading to BLM-dependent enhancement of RAD54-mediated chromatin remodelling.

AMBRA1 Promotes Intestinal Inflammation by Antagonizing PP4R1/PP4c Mediated IKK Dephosphorylation in an Autophagy-Independent Manner

[Cell Death & Differentiation] Investigators found that autophagy/beclin-1 regulator 1 (AMBRA1) was highly expressed in inflamed colons in a colitis mouse model and in clinical inflammatory bowel disease samples.