SOX-5 Activates a Novel RORγt Enhancer To Facilitate Experimental Autoimmune Encephalomyelitis by Promoting Th17 Cell Differentiation

Scientists identified a novel enhancer of RORγt gene in Th17 cells, RORCE2. RORCE2 deficiency suppressed RORγt expression and Th17 differentiation, leading to reduced severity of experimental autoimmune encephalomyelitis.
[Nature Communications]
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Restoring Metabolism of Myeloid Cells Reverses Cognitive Decline in Ageing

Researchers showed that in ageing mice myeloid cell bioenergetics are suppressed in response to increased signalling by the lipid messenger prostaglandin E2, a major modulator of inflammation.
[Nature]
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Designed PKC-Targeting Bryostatin Analogs Modulate Innate Immunity and Neuroinflammation

Scientists showed that multiple synthetically accessible bryologs replicate the anti-inflammatory effects of bryostatin-1 on innate immune cells in vitro, and a lead bryolog attenuates neuroinflammation in vivo.
[Cell Chemical Biology]
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Spatiotemporal Single-Cell Profiling Reveals That Invasive and Tissue-Resident Memory Donor CD8+ T Cells Drive Gastrointestinal Acute Graft-Versus-Host Disease

Scientists combined the serial intravascular staining technique with single-cell RNA sequencing to dissect the tightly connected processes by which donor T cells initially infiltrate tissues and then established a pathogenic tissue residency program in a rhesus macaque allo-HCT model that develops acute graft-versus-host disease.
[Science Translational Medicine]
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Substrate-Specific Recognition of IKKs Mediated by USP16 Facilitates Autoimmune Inflammation

Investigators found that IKKβ ubiquitination on lysine-238 was substantially increased during inflammation. Using mass spectrometry, they identified USP16 as an essential regulator of the IKKβ ubiquitination level that selectively affected p105 phosphorylation without directly affecting p65 or IκBα phosphorylation.
[Science Advances]
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Early-Life EV-A71 Infection Augments Allergen-Induced Airway Inflammation in Asthma through Trained Macrophage Immunity

Bone marrow-derived macrophages from recovered EV-A71-infected mice showed sustained innate immune memory that could drive naïve T helper cells toward Th2 and Th17 cell differentiation when in contact with mites.
[Cellular & Molecular Immunology]
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FYN–TRAF3IP2 Induces NF-κB Signaling-Driven Peripheral T-Cell Lymphoma

Consistent with a driver oncogenic role, FYN–TRAF3IP2 expression in hematopoietic progenitors induced NF-κB-driven T-cell transformation in mice and cooperated with loss of the Tet2 tumor suppressor in peripheral T-cell lymphoma development.
[Nature Cancer]
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3D High-Density Microelectrode Array with Optical Stimulation and Drug Delivery for Investigating Neural Circuit Dynamics

Researchers present a 3D high-density multifunctional microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics within engineered 3D neural tissues.
[Nature Communications]
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Epithelium-Derived Indian Hedgehog Restricts Stromal Expression of ErbB Family Members That Drive Colonic Tumor Cell Proliferation

Scientists found that recombinant EREG, BTC, and NRG1 but not Lgr5 ligand R-Spondin promoted growth and proliferation of Apc double mutant colonic organoids.
[Oncogene]
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Re-Expression of REG Family and DUOXs Genes in CRC Organoids by Co-Culturing With CAFs

Researchers found that the expression levels of several genes, which were highly expressed in original colorectal carcinoma tissues, were downregulated in organoids but re-expressed in organoids by co-culturing with cancer-associated fibroblasts.
[Scientific Reports]
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Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition

Using a high-throughput approach that combines enteroid monolayers and quantitative imaging, scientists identified conditions that enrich for specific cell types as well as interactions between pathways.
[Developmental Cell]
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