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Genetically Programmable Cell Membrane-Camouflaged Nanoparticles for Targeted Combination Therapy of Colorectal Cancer

[Signal Transduction and Targeted Therapy] Scientists introduced a cell membrane biomimetic nanodrug platform termed MPB-3BP@CM nanoparticles (NPs). Notably, blocking CD47 with MPB-3BP@CM NPs enhanced the phagocytosis of colorectal cancer cells by macrophages.

ACLS4 Could Be a Potential Therapeutic Target for Severe Acute Pancreatitis

[Scientific Reports] The authors conducted a comprehensive transcriptomic analysis of peripheral blood from patients with acute pancreatitis (AP) and the pancreatic tissue from a mouse model of AP. In mouse models of severe AP, ACSL4 was significantly upregulated in the pancreas, whereas GALNT3, WSB1, and IL1R1 were not.

Human Gastric Cancer Progression and Stabilization of ATG2B through RNF5 Binding Facilitated by Autophagy-Associated CircDHX8

[Cell Death & Disease] Researchers investigated the mechanism underlying the role of hsa_circ_003899 (circDHX8) in the malignancy of gastric cancer (GC). CircDHX8 was identified as upregulated and shown to enhance the malignant progression in GC cells by promoting cellular autophagy.

Generation of Salivary Glands Derived from Pluripotent Stem Cells via Conditional Blastocyst Complementation

[Cell Reports] Scientists identified the Foxa2 lineage as a critical lineage for salivary gland development through conditional blastocyst complementation.

Suppression of Smooth Muscle Cell Inflammation by Myocardin-Related Transcription Factors Involves Inactivation of TANK-Binding Kinase 1

[Scientific Reports] Researchers tested if myocardin-related transcription factors suppressed inflammation also by targeting cGAS-STING signaling. Interrogation of a transcriptomic dataset where myocardin was overexpressed using a panel of 56 cGAS-STING cytokines showed the panel to be repressed.

Direct RNA Sequencing of Astronaut Blood Reveals Spaceflight-Associated m6A Increases and Hematopoietic Transcriptional Responses

[Nature Communications] Scientists reported key genetic pathways, including changes in erythrocyte regulation, stress induction, and immune changes affected by spaceflight.