Removal of CD276+ Cells from Haploidentical Memory T-Cell Grafts Significantly Lowers the Risk of GVHD

Analysis of CD45RA-depleted haploidentical mixed lymphocytes culture revealed insufficient suppression of alloresponses in the CD4+ compartment and identified CD276 as a marker for alloreactive memory Th1 T cells.
[Bone Marrow Transplantation]
Hashimoto, H., Kasteleiner, P., Kressin, J., Müller, F., Bühring, H.-J., Handgretinger, R., & Schilbach, K. (2021). Removal of CD276 + cells from haploidentical memory T-cell grafts significantly lowers the risk of GVHD. Bone Marrow Transplantation, 1–19. https://doi.org/10.1038/s41409-021-01307-9 Cite
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Engineered Red Blood Cells as an Off-the-Shelf Allogeneic Anti-Tumor Therapeutic

Researchers engineered red blood cells into artificial antigen-presenting cells presenting a peptide bound to the major histocompatibility complex I, the costimulatory ligand 4-1BBL, and interleukin-12.
[Nature Communications]
Zhang, X., Luo, M., Dastagir, S. R., Nixon, M., Khamhoung, A., Schmidt, A., Lee, A., Subbiah, N., McLaughlin, D. C., Moore, C. L., Gribble, M., Bayhi, N., Amin, V., Pepi, R., Pawar, S., Lyford, T. J., Soman, V., Mellen, J., Carpenter, C. L., … Chen, T. F. (2021). Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic. Nature Communications, 12(1), 2637. https://doi.org/10.1038/s41467-021-22898-3 Cite
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DNMT3A Haploinsufficiency Causes Dichotomous DNA Methylation Defects at Enhancers in Mature Human Immune Cells

The authors demonstrated that DNMT3A haploinsufficiency impaired the gain of DNA methylation at decommissioned enhancers, while simultaneously and unexpectedly impairing DNA demethylation of newly activated enhancers in mature human myeloid cells.
[Journal of Experimental Medicine]
Lim, J.-Y., Duttke, S. H., Baker, T. S., Lee, J., Gambino, K. J., Venturini, N. J., Ho, J. S. Y., Zheng, S., Fstkchyan, Y. S., Pillai, V., Fajgenbaum, D. C., Marazzi, I., Benner, C., & Byun, M. (2021). DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells. Journal of Experimental Medicine, 218(e20202733). https://doi.org/10.1084/jem.20202733 Cite
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The Human Memory T Cell Compartment Changes across Tissues of the Female Reproductive Tract

Scientists examined CD4 T cells in donor-matched vaginal, ecto- and endocervical tissues, which differ in mucosal structure and exposure to external environmental stimuli.
[Mucosal Immunology]
Woodward Davis, A. S., Vick, S. C., Pattacini, L., Voillet, V., Hughes, S. M., Lentz, G. M., Kirby, A. C., Fialkow, M. F., Gottardo, R., Hladik, F., Lund, J. M., & Prlic, M. (2021). The human memory T cell compartment changes across tissues of the female reproductive tract. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-021-00406-6 Cite
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Immune Cellular Networks Underlying Recovery from Influenza Virus Infection in Acute Hospitalized Patients

Investigators reported the dynamics of 18 important immune parameters, related to clinical, genetic and virological factors, in influenza patients across different severity levels.
[Nature Communications]
Nguyen, T. H. O., Koutsakos, M., van de Sandt, C. E., Crawford, J. C., Loh, L., Sant, S., Grzelak, L., Allen, E. K., Brahm, T., Clemens, E. B., Auladell, M., Hensen, L., Wang, Z., Nüssing, S., Jia, X., Günther, P., Wheatley, A. K., Kent, S. J., Aban, M., … Kedzierska, K. (2021). Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients. Nature Communications, 12(1), 2691. https://doi.org/10.1038/s41467-021-23018-x Cite
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Neutralizing Antibody Responses to SARS-CoV-2 in Symptomatic COVID-19 Is Persistent and Critical for Survival

The presence of neutralizing antibodies within the first weeks from symptoms onset correlated with time to a negative swab result, while the lack of neutralizing capacity correlates with an increased risk of a fatal outcome.
[Nature Communications]
Dispinseri, S., Secchi, M., Pirillo, M. F., Tolazzi, M., Borghi, M., Brigatti, C., De Angelis, M. L., Baratella, M., Bazzigaluppi, E., Venturi, G., Sironi, F., Canitano, A., Marzinotto, I., Tresoldi, C., Ciceri, F., Piemonti, L., Negri, D., Cara, A., Lampasona, V., & Scarlatti, G. (2021). Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival. Nature Communications, 12(1), 2670. https://doi.org/10.1038/s41467-021-22958-8 Cite
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Hyaluronic Acid Is a Negative Regulator of Mucosal Fibroblast-Mediated Enhancement of HIV Infection

Since inflammation is known to facilitate HIV sexual transmission, researchers investigated the role of hyaluronic acid in genital mucosal fibroblast-mediated enhancement of HIV infection.
[Mucosal Immunology]
Egedal, J. H., Xie, G., Packard, T. A., Laustsen, A., Neidleman, J., Georgiou, K., Pillai, S. K., Greene, W. C., Jakobsen, M. R., & Roan, N. R. (2021). Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-021-00409-3 Cite
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Pertussis Immunization during Pregnancy: Assessment of the Role of Maternal Antibodies on Immune Responses in Term and Preterm Born Infants

Researchers report its effect at birth and on antibody-mediated immune responses to a DTaP-IPV-HB-PRP~T vaccine in preterm compared to term infants.
[Clinical infectious Diseases]
Maertens, K., Orije, M. R. P., Herzog, S. A., Mahieu, L. M., Hens, N., Van Damme, P., & Leuridan, E. (2021). Pertussis immunization during pregnancy: assessment of the role of maternal antibodies on immune responses in term and preterm born infants. Clinical Infectious Diseases, ciab424. https://doi.org/10.1093/cid/ciab424 Cite
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Asymmetric Cell Division Shapes Naive and Virtual Memory T Cell Immunity during Aging

Investigators found that aging, known to negatively impact immune responses, impaired asymmetric cell division in murine CD8+ T cells, and that this phenotype could be rescued by transient mTOR inhibition.
[Nature Communications]
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Conserved Human Effector Treg Cell Transcriptomic and Epigenetic Signature in Arthritic Joint Inflammation

The authors combined transcriptional and epigenetic profiling to identify a human effector Treg cell signature.
[Nature Communications]
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Dual Vaccination against IL-4 and IL-13 Protects against Chronic Allergic Asthma in Mice

Investigators developed conjugate vaccines against mouse IL-4 and IL-13, and demonstrated their prophylactic and therapeutic efficacy in reducing IgE levels, AHR, eosinophilia and mucus production in mouse models of asthma analyzed up to 15 weeks after initial vaccination.
[Nature Communications]
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