Tag Archives: type-publication

Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage

Scientists systematically investigated the expression profiles of 1,436 murine RNA-binding proteins in the developing mouse brain and identified quaking as a marker of the putative glial precursor cells population.
[Stem Cell Reports]
Takeuchi, A., Takahashi, Y., Iida, K., Hosokawa, M., Irie, K., Ito, M., Brown, J. B., Ohno, K., Nakashima, K., & Hagiwara, M. (2020). Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.08.010 Cite
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Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development

Investigators profiled the neuroelectrical activities of cerebral organoids over the span of five months with a multi-electrode array platform and observed the emergence and maturation of several electrophysiologic properties, including rapid firing rates and network bursting events.
[Stem Cell Reports]
Fair, S. R., Julian, D., Hartlaub, A. M., Pusuluri, S. T., Malik, G., Summerfied, T. L., Zhao, G., Hester, A. B., Ackerman, W. E., Hollingsworth, E. W., Ali, M., McElroy, C. A., Buhimschi, I. A., Imitola, J., Maitre, N. L., Bedrosian, T. A., & Hester, M. E. (2020). Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2020.08.017 Cite
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Insulin and Leptin/Upd2 Exert Opposing Influences on Synapse Number in Fat-Sensing Neurons

Researchers showed that under conditions of nutrient surplus, Upd2, a Drosophila leptin ortholog, regulated actin-based synapse reorganization to reduce bouton number in an inhibitory circuit, thus establishing a neural tone that was permissive for insulin release.
[Cell Metabolism]
Brent, A. E., & Rajan, A. (2020). Insulin and Leptin/Upd2 Exert Opposing Influences on Synapse Number in Fat-Sensing Neurons. Cell Metabolism, 0(0). https://doi.org/10.1016/j.cmet.2020.08.017 Cite
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LncRNA BCYRN1 Inhibits Glioma Tumorigenesis by Competitively Binding with miR-619-5p to Regulate CUEDC2 Expression and the PTEN/AKT/p21 Pathway

Three fresh tumor tissues from glioma patients and three normal brain tissues from craniocerebral trauma patients were prepared for high-throughput RNA sequencing.
[Oncogene]
Mu, M., Niu, W., Zhang, X., Hu, S., & Niu, C. (2020). LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01466-x Cite
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Onco-Fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

The hepatocellular carcinoma ecosystem displayed features reminiscent of fetal development, including re-emergence of fetal-associated endothelial cells and fetal-like tumor-associated macrophages.
[Cell]
Sharma, A., Seow, J. J. W., Dutertre, C.-A., Pai, R., Blériot, C., Mishra, A., Wong, R. M. M., Singh, G. S. N., Sudhagar, S., Khalilnezhad, S., Erdal, S., Teo, H. M., Khalilnezhad, A., Chakarov, S., Lim, T. K. H., Fui, A. C. Y., Chieh, A. K. W., Chung, C. P., Bonney, G. K., … DasGupta, R. (2020). Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.08.040 Cite
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Nanoparticle Enhanced Combination Therapy for Stem-Like Progenitors Defined by Single-Cell Transcriptomics in Chemotherapy-Resistant Osteosarcoma

Scientists utilized single-cell transcriptomics to systematically map the cell-type-specific gene expression in a chemotherapy-resistant osteosarcoma tumor.
[Signal Transduction and Targeted Therapy]
Wang, L., Huang, X., You, X., Yi, T., Lu, B., Liu, J., Lu, G., Ma, M., Zou, C., Wu, J., & Zhao, W. (2020). Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00248-x Cite
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Spatiotemporal Restriction of Endothelial Cell Calcium Signaling Is Required during Leukocyte Transmigration

Endothelial calmodulin (CaM), a key calcium signaling protein, interacts with the IQ domain of IQGAP1, which is localized to endothelial junctions and is required for leukocyte transendothelial migration.
[Journal of Experimental Medicine]
Dalal, P. J., Sullivan, D. P., Weber, E. W., Sacks, D. B., Gunzer, M., Grumbach, I. M., Heller Brown, J., & Muller, W. A. (2021). Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration. Journal of Experimental Medicine, 218(1). https://doi.org/10.1084/jem.20192378 Cite
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Myh11+ Microvascular Mural Cells and Derived Mesenchymal Stem Cells Promote Retinal Fibrosis

Using lineage tracing technology, researchers demonstrated that after chemical ocular injury, Myh11+ mural cells detached from the retinal microvasculature and differentiated into myofibroblasts to form an epiretinal membrane.
[Scientific Reports]
Ray, H. C., Corliss, B. A., Bruce, A. C., Kesting, S., Dey, P., Mansour, J., Seaman, S. A., Smolko, C. M., Mathews, C., Dey, B. K., Owens, G. K., Peirce, S. M., & Yates, P. A. (2020). Myh11+ microvascular mural cells and derived mesenchymal stem cells promote retinal fibrosis. Scientific Reports, 10(1), 15808. https://doi.org/10.1038/s41598-020-72875-x Cite
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Osteogenic Differentiation Potential of Porcine Bone Marrow Mesenchymal Stem Cell Subpopulations Selected in Different Basal Media

Scientists evaluated the effects of αMEM, aDMEM, M199, αMEM/M199, aDMEM/M199 and αMEM/aDMEM mediaon porcine bone marrow MSC derivation, expression of number of osteogenic markers at fifth and tenth passage in multipotentporcine (p)MSCs before differentiation, and differentiation of pMSC to osteogenic lineage.
[Biology Open]
Kannan, S., Ghosh, J., & Dhara, S. K. (2020). Osteogenic differentiation potential of porcine bone marrow mesenchymal stem cell subpopulations selected in different basal media. Biology Open. https://doi.org/10.1242/bio.053280 Cite
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Clinical Effects of Intrathecal Administration of Expanded Wharton Jelly Mesenchymal Stromal Cells in Patients with Chronic Complete Spinal Cord Injury: A Randomized Controlled Study

Patients were randomly assigned to receive a single dose of intrathecal ex vivo-expanded Wharton’s jelly-MSCs from human umbilical cord or placebo and were then switched to the other arm at six months.
[Cytotherapy]
Albu, S., Kumru, H., Coll, R., Vives, J., Vallés, M., Benito-Penalva, J., Rodríguez, L., Codinach, M., Hernández, J., Navarro, X., & Vidal, J. (2020). Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2020.08.008 Cite
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The miR-361-3p Increases Enzalutamide (Enz) Sensitivity via Targeting the ARv7 and MKNK2 to Better Suppress the Enz-Resistant Prostate Cancer

Researchers identified a microRNA, miR-361-3p, whose expression is lower in patients with recurrent prostate cancer, could function via binding to the 3′UTR of ARv7, but not the wild type of androgen receptor, to suppress its expression to increase the Enz sensitivity.
[Cell Death & Disease]
Liu, B., Sun, Y., Tang, M., Liang, C., Huang, C.-P., Niu, Y., Wang, Z., & Chang, C. (2020). The miR-361-3p increases enzalutamide (Enz) sensitivity via targeting the ARv7 and MKNK2 to better suppress the Enz-resistant prostate cancer. Cell Death & Disease, 11(9), 1–12. https://doi.org/10.1038/s41419-020-02932-w Cite
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