Publication

[Gut] Researchers aimed to develop mouse models of sporadic and hereditary DGC by inactivation of Cdh1 in the mouse stomach. They generated tamoxifen-inducible Cre/loxP mouse models of DGC driven by the Cd44 promoter with a tdTomato reporter.

[Cell Reports] Scientists employed mouse genetics to reveal that Hippo signaling regulates stomach epithelial development by balancing epithelial proliferation and differentiation.

[Biology Direct] Researchers identified mixed lineage kinase domain-like protein (MLKL) as a key regulator of ferroptosis resistance in colorectal cancer, promoting tumor cell survival by coordinating antioxidant defenses and ESCRT-III–mediated membrane repair.

[International Immunopharmacology] Investigators identified ecto-nicotinamide adenine dinucleotide oxidase 1 (ENOX1) as a driver of gastric cancer progression, promoting epithelial–mesenchymal transition and M2 macrophage polarization through Snail2 signaling.

[Bioorganic Chemistry] Scientists developed AspMet, a dual MET/COX-2 inhibitor that suppresses gastric and colorectal cancer growth by blocking oncogenic signaling, epithelial–mesenchymal transition, and angiogenesis.

[Biochemical and Biophysical Research Communications] Researchers showed that lactate-driven S100A8 lactylation stabilizes the protein by blocking RNF5-mediated degradation, promoting colorectal cancer progression.