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CAR Affinity Modulates the Sensitivity of CAR-T Cells to PD-1/PD-L1-Mediated Inhibition

[Nature Communications] The authors interrogated CAR-T cells targeting HER2 with either low or high affinity in various preclinical models.

Emx2 Underlies the Development and Evolution of Marsupial Gliding Membranes

[Nature] By combining epigenomics, transcriptomics and in-pouch marsupial transgenics, scientists showed that Emx2 was a critical upstream regulator of patagium development.

Designing Biomimetic 3D-Printed Osteochondral Scaffolds for Enhanced Load-Bearing Capacity

[Tissue Engineering Part A] Cmputational simulations revealed that interfacial fibrils within a bilayer alter osteochondral scaffold deformation patterns by redirecting load-induced stresses toward the top of the cartilage layer.

TANGO1 Inhibitors Reduce Collagen Secretion and Limit Tissue Scarring

[Nature Communications] Investigators designed membrane permeant peptide inhibitors that specifically target the primary interface between TANGO1 and cTAGE5, an interaction that is required for collagen export from endoplasmic reticulum exit sites

Theaflavin-3,3′-Digallate Protects Liver and Kidney Functions in Diabetic Rats by Up-Regulating Circ-ITCH and Nrf2 Signaling Pathway

[Journal Of Agricultural And Food Chemistry] Research indicated that TFDG administration effectively lowered the fasting blood glucose and serum lipid concentrations and enhanced the functionality and cellular architecture of the liver and kidney in rats with diabetes.

Integration of Single-Cell RNA-Seq and Bulk RNA-Seq to Construct Liver Hepatocellular Carcinoma Stem Cell Signatures to Explore Their Impact on Patient Prognosis and Treatment

[PLOS One] The authors explored the association of stemness indicators with survival outcomes and clinical characteristics by combining clinical information and survival analyses.

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