Publication

[Nature] The authors established that the presence of diverse priming events in the normal mouse intestinal epithelium can change the transformation and clonal-selection landscape, permitting the fixation of strong driver mutations in Apc and Ctnnb1 that are otherwise lost due to negative selection.

[Nature Communications] Scientists showed that cellular redox balance orchestrates niche factors with metabolic state to govern cell fate decisions.

[Nature Aging] By analyzing DNA methylation and gene expression data from healthy and cancerous human colon samples, investigators identified an aging and colon cancer-associated DNA methylation drift.

[Experimental & Molecular Medicine] The authors identified increased heterogeneous nuclear ribonucleoprotein U (HnRNPU) expression in patients with colon adenocarcinoma, with higher levels correlating with poor patient survival.

[Oncogene] Researchers identified that TATA-binding protein-associated factor-1 (TAF1), also as a lysine acetyltransferase, is frequently upregulated in colorectal cancer.

[Communications Biology] Scientists showed that protein Kinase A (PKA) is central to a signaling cascade involving the G protein-coupled estrogen receptor GPER1, which is essential for centrosome integrity in colon cancer cells.