Scientists identified a novel enhancer of RORγt gene in Th17 cells, RORCE2. RORCE2 deficiency suppressed RORγt expression and Th17 differentiation, leading to reduced severity of experimental autoimmune encephalomyelitis.
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Researchers showed that in ageing mice myeloid cell bioenergetics are suppressed in response to increased signalling by the lipid messenger prostaglandin E2, a major modulator of inflammation.
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Scientists showed that multiple synthetically accessible bryologs replicate the anti-inflammatory effects of bryostatin-1 on innate immune cells in vitro, and a lead bryolog attenuates neuroinflammation in vivo.
[Cell Chemical Biology]
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Scientists combined the serial intravascular staining technique with single-cell RNA sequencing to dissect the tightly connected processes by which donor T cells initially infiltrate tissues and then established a pathogenic tissue residency program in a rhesus macaque allo-HCT model that develops acute graft-versus-host disease.
[Science Translational Medicine]
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Investigators found that IKKβ ubiquitination on lysine-238 was substantially increased during inflammation. Using mass spectrometry, they identified USP16 as an essential regulator of the IKKβ ubiquitination level that selectively affected p105 phosphorylation without directly affecting p65 or IκBα phosphorylation.
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Bone marrow-derived macrophages from recovered EV-A71-infected mice showed sustained innate immune memory that could drive naïve T helper cells toward Th2 and Th17 cell differentiation when in contact with mites.
[Cellular & Molecular Immunology]
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Consistent with a driver oncogenic role, FYN–TRAF3IP2 expression in hematopoietic progenitors induced NF-κB-driven T-cell transformation in mice and cooperated with loss of the Tet2 tumor suppressor in peripheral T-cell lymphoma development.
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Researchers present a 3D high-density multifunctional microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics within engineered 3D neural tissues.
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Scientists found that recombinant EREG, BTC, and NRG1 but not Lgr5 ligand R-Spondin promoted growth and proliferation of Apc double mutant colonic organoids.
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Researchers found that the expression levels of several genes, which were highly expressed in original colorectal carcinoma tissues, were downregulated in organoids but re-expressed in organoids by co-culturing with cancer-associated fibroblasts.
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Using a high-throughput approach that combines enteroid monolayers and quantitative imaging, scientists identified conditions that enrich for specific cell types as well as interactions between pathways.
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