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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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Virologist Awarded $2 Million NIH Grant to Investigate How Virus-Infected Cells Live and Die
[Virginia Tech (EurekAlert)] Dr. James Weger-Lucarelli at the Virginia-Maryland College of Veterinary Medicine, received a five-year, $2.01 million award from the National Institute of General Medical Sciences to investigate how virus-infected cells live and die, and what they signal to their neighbors when they do.
Clinical Trial for an Oral Drug to Treat Ebola is Registered in the Pan African Clinical Trials Database and is Ready to Go, As...
[NanoViricides, Inc. (BioSpace)] NanoViricides, Inc. announced that its Phase II Clinical Trial of NV-387 Oral Gummies as a Treatment for the Current Bundibugyo Ebolavirus and other Ebola viruses in the Democratic Republic of Congo was successfully registered in the Pan African Clinical Trials Registry.
Microbial Adhesion Promotes Piezo1 Activation to Initiate Innate Immunity
[Nature Immunology] Scientists identified microbial adhesion to myeloid cells as a critical initiating event that precedes pattern recognition receptor engagement. Using a skin infection model with pathogenic bacteria and fungi, they demonstrated that neutrophil recruitment occurs in two sequential phases.
Twenty-Year Persistence of SARS-CoV-1 Immune Imprinting Shapes Antibody Responses to SARS-CoV-2 Infection
[Immunity] Researchers studied individuals sequentially infected with SARS-CoV-1 and SARS-CoV-2 over two decades and found durable imprinting of antibody responses following SARS-2 BF.7 breakthrough infection.
Immunometabolic Control of Neutrophil Plasticity in Tuberculosis
[Human Vaccines & Immunotherapeutics] The authors integrate emerging evidence that defines immunometabolic adaptation as a key determinant of neutrophil plasticity in tuberculosis.
New Thinking for the Next Generation of Antimalarials
[EMBO Molecular Medicine] Scientists examine the discovery and development of next-generation antimalarials, including advances in phenotypic and target-based screening, omics-enabled target discovery, and emerging therapeutic modalities such as long-acting agents, targeted covalent inhibitors, and host-directed therapies.
SESN1 Is a Negative Regulator of MAVS and Dynamically Expressed during RNA Viral Infection
[Proceedings of the National Academy of Sciences of the United States of America] Investigators reported that SESN1 acts as a critical negative regulator of mitochondrial antiviral signaling protein (MAVS), a central hub protein in RNA-triggered innate immune response, by potentiating MAVS autophagic degradation to repress innate immune response.
Engineering Antigenic Breadth against SARS-CoV-2 by Pairing Divergent RBDs Within a Single mRNA Immunogen
[Proceedings of the National Academy of Sciences of the United States of America] Researchers designed an mRNA vaccine in which two antigenically distinct SARS-CoV-2 variant receptor binding domains (RBDs) are physically fused on a single polypeptide. This design is predicted to favor B cell antigen receptors capable of engaging conserved epitopes on both RBDs with enhanced avidity.
Innate Immune Imprints Shape HIV-1 Reservoir Cell Persistence during Long-Term Antiretroviral Therapy
[Nature Immunology] Analyzing over 6,000 proviral DNA amplicons from 104 individuals on long-term antiretroviral therapy, the authors found that carriers of HLA-C2 allotypes, which promote NK cell education via interactions with KIR2DL1, exhibited lower frequencies of intact proviruses.
Local Lactate-Driven H3K18 Lactylation Impairs Anti-Influenza Immunity through NRF2-Dependent Dendritic Cell Dysfunction
[Cell Reports] By integrating time-series targeted energy metabolomics, single-cell RNA sequencing, flow cytometry, and functional perturbation, scientists showed that influenza virus infection preferentially increases lactate within the lung microenvironment, where it restrains pulmonary CD8+ T cell response.
MicrobiotiX Completes Sentinel Cohort of its First-in-Human Clinical Trial of MP101 for Pneumonia
[MicrobiotiX (BioSpace)] MicrobiotiX announced the successful completion of the sentinel cohort of its first-in-human Phase I clinical trial evaluating MP101 in patients with pneumonia caused by Pseudomonas aeruginosa.
Will the mRNA Flu Shot Work Better Than a Regular Seasonal One? What the Science Says
[Nature] The US FDA granted approval to Moderna’s mRNA-based flu vaccine, mFLUSIVA, for adults aged 50–64, and accelerated approval for adults aged 65 and older.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
