Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

The E3 Ligase HERC5 Promotes Antimycobacterial Responses in Macrophages by ISGylating the Phosphatase PTEN

[Science Signaling] Investigators explored the role of ISGylation in the macrophage response to infection with Mycobacterium tuberculosis.

Current Treatment Strategies for EGFR-Mutated Non-Small Cell Lung Cancer: From First Line to Beyond Osimertinib Resistance

[Japanese Journal Of Clinical Oncology] The authors describe current pharmacotherapeutic strategies for epidermal growth factor receptor (EGFR)-mutated NSCLC based on the results of clinical trials and the latest published data.

Tissue-Resident Memory T Cells Mediate Mucosal Immunity to Recurrent Urinary Tract Infection

[Science Immunology] Researchers found that reducing bacterial load early in infection, by reducing the inoculum or with antibiotics after infection, completely abrogated the protective memory response of tissue resident memory T cells.

Inhibition of SARS-CoV-2-Mediated Thromboinflammation by CLEC2.Fc

[EMBO Molecular Medicine] Scientists found that the spleen tyrosine kinase-coupled C-type lectin member 2 (CLEC2), which was highly expressed in platelets and alveolar macrophages, interacted with the receptor-binding domain of SARS-CoV-2 spike protein directly.

Nirmatrelvir Treatment of SARS-CoV-2-Infected Mice Blunts Antiviral Adaptive Immune Responses

[EMBO Molecular Medicine] By using mouse models of SARS-CoV-2 infection, investigators showed that nirmatrelvir administration blunts the development of SARS-CoV-2-specific antibody and T cell responses.

Generation of Host-Directed and Virus-Specific Antivirals Using Targeted Protein Degradation Promoted by Small Molecules and Viral RNA Mimics

[Cell Host & Microbe] Scientists applied proteolysis-targeting chimera approaches to develop broad-spectrum antivirals targeting key host factors for many viruses and virus-specific antivirals targeting unique viral proteins.

Antiviral Effect of SARS-CoV-2 N-specific CD8+ T Cells Induced in Lungs by Engineered Extracellular Vesicles

[NPJ Vaccines] The authors investigated the immunity generated in the lungs by N-engineered extracellular vesicles in terms of induction of N-specific effectors and resident memory CD8+ T lymphocytes before and after virus challenge before and after virus challenge carried out three weeks and three months after boosting..

Platelets and Mast Cells Promote Pathogenic Eosinophil Recruitment during Invasive Fungal Infection via the 5-HIAA-GPR35 Ligand-Receptor System

[Immunity] Given the inflammatory nature of cryptococcal infection, the authors examined the role of GPR35 in the circuitry underlying cell recruitment to the lung.

Differential Localization of Dengue Virus Protease Affects Cell Homeostasis and Triggers to Thrombocytopenia

[iScience] Scientists showed the differential localization of existing two forms of dengue virus protease i.e., NS2BNS3 to the nucleus and NS3 to the nucleus and mitochondria.

Hamster Model for Post-COVID-19 Alveolar Regeneration Offers an Opportunity to Understand Post-acute Sequelae of SARS-CoV-2

[Nature Communications] Investigators demonstrated that CK8+ alveolar differentiation intermediate cells occured following SARS-CoV-2-induced diffuse alveolar damage.

SARS-CoV-2 and the Nervous System: Current Perspectives

[Archives of Virology] The authors discuss literature focusing on clinical observations that suggest associations between SARS-CoV-2 infection and the nervous system.

China’s Rolling COVID Waves Could Hit Every Six Months — Infecting Millions

[Nature] The latest surge is unlikely to crash the country’s health-care system, but scientists fear hundreds of millions of infections.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.