Integrated Histopathological, Lipidomic, and Metabolomic Profiles Reveal Mink Is a Useful Animal Model to Mimic the Pathogenicity of Severe COVID-19 Patients

The authors demonstrated that minks were largely permissive to SARS-CoV-2, characterized by severe and diffuse alveolar damage, and lasted at least 14 days post inoculation.
[Signal Transduction and Targeted Therapy]
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Immune Imprinting, Breadth of Variant Recognition and Germinal Center Response in Human SARS-CoV-2 Infection and Vaccination

Scientists analyzed human lymph nodes after infection or mRNA vaccination for correlates of serological differences.
[Cell]
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Todos Medical and NLC Pharma Announce Primary and Secondary Endpoints Met in NLC-V-01 Phase II Clinical Trial of Oral Antiviral 3CL Protease Inhibitor Tollovir™ in the Treatment of Hospitalized COVID-19 Patients

Todos Medical, Ltd. announced positive interim data for its Tollovir™ oral antiviral 3CL protease inhibitor Phase II clinical trial for the treatment of hospitalized (severe and critical) COVID-19 patients.
[Todos Medical, Ltd.]
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Lung-Resident Memory B Cells Established after Pulmonary Influenza Infection Display Distinct Transcriptional and Phenotypic Profiles

Scientists characterized tissue-resident memory B cells that are stably maintained in the lungs of mice after pulmonary influenza infection.
[Science Immunology]
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It’s Too Early to Tell Whether CBD Helps against COVID-19 — but Researchers Worry That Won’t Stop CBD Makers

The latest hubbub is an example of both the promise of cannabinoids — components of cannabis — as potential therapies, but also the hype around them, which can far outpace the evidence that they work.
[STAT]
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Low CCR5 Expression Protects HIV-Specific CD4+ T Cells of Elite Controllers from Viral Entry

Ex vivo characterization of single Gag-specific CD4+ T cells revealed an advanced Th1 differentiation pattern in controllers, except for the CCR5 marker, which was downregulated compared to specific cells of treated patients.
[Nature Communications]
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Aligos Therapeutics Begins Dosing in Chronic Hepatitis B Patients in Its Phase I Antisense Oligonucleotide Study (ALG-020572-401)

Aligos Therapeutics, Inc. announced that the first chronic hepatitis B patient has been dosed in the multiple ascending dose portion of Study ALG-020572-401 which is evaluating antisense oligonucleotide ALG-020572.
[Aligos Therapeutics, Inc.]
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The SARS-CoV-2 Monoclonal Antibody Combination, AZD7442, Is Protective in Non-Human Primates and Has an Extended Half-Life in Humans

The authors described AZD7442, a combination of two mAbs, AZD8895 and AZD1061, that simultaneously bound to distinct, nonoverlapping epitopes on the spike protein receptor binding domain to neutralize SARS-CoV-2.
[Science Translational Medicine]
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Vaccination before or after SARS-CoV-2 Infection Leads to Robust Humoral Response and Antibodies That Effectively Neutralize Variants

Investigators measured neutralizing antibody responses from 104 vaccinated individuals, including those with breakthrough infections, hybrid immunity, and no infection history.
[Science Immunology]
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DOCK2 Regulates Antifungal Immunity by Regulating RAC GTPase Activity

Scientists reported that dedicator of cytokinesis 2 (DOCK2) promoted indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.
[Cellular & Molecular Immunology]
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CRISPR/Cas9-Mediated Gene Disruption of Endogenous Co-Receptors Confers Broad Resistance to HIV-1 in Human Primary Cells and Humanized Mice

In a humanized mouse model under HIV-1 challenge, CXCR4-disrupted CD4+ T cells were enriched in the peripheral blood and spleen, indicating survival advantage due to resistance to viral infection.
[Molecular Therapy-Methods & Clinical Development]
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