Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

Mesenchymal Stem Cells Prevent H7N9 Virus Infection via Rejuvenating Immune Environment to Inhibit Immune-Overactivity

[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] ICR mice were pretreated with human umbilical cord (hUC) MSCs and then infected with the influenza H7N9 virus. Weight, survival days, and lung index of mice were recorded.

Immunoregulatory Nanomedicine for Respiratory Infections

[Nature Reviews Bioengineering] Scientists discuss the design of nanovaccines, including lipid-nanocarrier-based messenger RNA nanovaccines, highlighting engineering strategies for different administration routes, including nasal administration.

The Neurobiology of SARS-CoV-2 Infection

[Nature Reviews Neuroscience] The authors put special emphasis on discussing the methodological difficulties of viral detection in central nervous system (CNS) tissue and discuss immune-based effects contributing to COVID-19-related CNS affection.

SARS-CoV-2 Spike Receptor-Binding Domain Is Internalized and Promotes Protein ISGylation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

[Scientific Reports] Researchers investigated the direct effects of spike receptor-binding domain on human cardiomyocytes differentiated from induced pluripotent stem cells.

Effectiveness of VSV Vectored SARS-CoV-2 Spike When Administered Through Intranasal, Intramuscular or a Combination of Both

[Scientific Reports] Scientists investigated the immunogenicity and efficacy of a prime-boost immunization regimen administered intranasally, intramuscularly, or combinations of the two.

Aimd Congo’s Deadliest Mpox Outbreak, a New Worry: Virus has Become Sexually Transmissible

[Science] The WHO report and a study explored a worrisome possibility: that the strain of virus in the Democratic Republic of the Congo, far deadlier than the one that drove the global outbreak, is in some cases spreading between sexual partners.

A New mRNA Malaria Vaccine

[The Scientist] Researchers reported a new mRNA vaccine that induced a tailored immune response in the livers of mice via the activation of liver-specific tissue-resident memory T cells, which control early stages of infection and prevent illness.

Cytolytic Circumsporozoite-Specific Memory CD4+ T Cell Clones Are Expanded During Plasmodium falciparum Infection

[Nature Communications] Investigators compared the cellular and humoral immune response of clinically immune and susceptible during a mild episode of Plasmodium falciparum malaria infection in a malaria endemic region of Malawi, by analyzing peripheral blood samples using high dimensional mass cytometry, spectral flow cytometry, and single-cell transcriptomic analyses.

Sequential Vaccinations with Divergent H1N1 Influenza Virus Strains Induce Multi-H1 Clade Neutralizing Antibodies in Swine

[Nature Communications] Scientists induced a pan-H1N1 antibody response in pigs by sequential vaccination with antigenically divergent H1N1 strains.

Conjugation of HIV-1 Envelope to Hepatitis B Surface Antigen Alters Vaccine Responses in Rhesus Macaques

[NPJ Vaccines] Researchers developed an innovative conjugate vaccine regimen that used a modified vaccinia virus Ankara co-expressing HIV-1 envelope and the hepatitis B virus surface antigen as a prime, followed by two Env–HBsAg conjugate protein boosts.

Nicotinamide Mononucleotide Impacts HIV-1 Infection by Modulating Immune Activation in T Lymphocytes and Humanized Mice

[eBioMedicine] Investigators examined HIV-1 integrated DNA or transcribed RNA, intracellular p24 protein, and T cell activation markers in CD4+ T cells including in vitro HIV-1-infected cells, reactivated patient-derived cells, and in HIV-1-infected humanized mice, under NMN treatment.

Self-Assembled Multiepitope Nanovaccine Provides Long-Lasting Cross-Protection Against Influenza Virus

[Advanced Healthcare Materials] Multiple linear epitopes from the conserved stem domain of hemagglutinin and the ectodomain of matrix protein 2 were combined with the Helicobacter pylori ferritin, a stable self-assembled nanoplatform, to develop an influenza multiepitope nanovaccine, named MHF.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.