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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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Chronic Active Epstein-Barr Virus Disease: Molecular Pathogenesis, Evolving Concepts, and Emerging Therapies
[Blood] Recent studies support a model in which mutated Epstein-Barr virus infects hematopoietic stem or lymphoid progenitor cells in the bone marrow, establishing latent infection that persists as these progenitors differentiate into T/NK cells.
Persistent IFN-I Signaling Inhibits Mitochondrial Oxidative Metabolism in CD8 T Cells during HIV-1 Infection Under cART
[Cellular & Molecular Immunology] Scientists showed that in humanized mice and cells from people living with HIV-1, IFN-I signaling impaired mitochondrial activity in CD8+ T cells during chronic HIV-1 infection with effective antiretroviral therapy.
Immune Endotypes in Tuberculosis: Keys to Decoding Disease Complexity
[Journal of Internal Medicine] The authors underscore the potential of immune endotypes to advance precision medicine in Tuberculosis, moving beyond one-size-fits-all treatment to improve outcomes, especially in severe and drug-resistant cases.
Hepatitis E Virus Replication Is Maintained in Proliferative Cells within the Intestinal Crypt
[Science Advances] Investigators demonstrated that hepatitis E virus (HEV) predominantly infects proliferative transit-amplifying and intestinal stem cells within the crypts of hPSC–derived intestinal organoids (hIOs). They found that HEV infection spreads through cell division and is maintained in hIOs for more than 40 days, contrasting with acute hepatitis A virus, whose infections are rapidly cleared from hIOs.
Cocrystal Pharma Receives FDA Fast Track Designation for CDI-988 for Norovirus Infection Treatment and Preventive
[Cocrystal Pharma, Inc. ] Cocrystal Pharma, Inc. announced that the US FDA has granted Fast Track designation to its oral, direct-acting protease inhibitor, CDI-988, the first oral antiviral candidate being developed for treatment and prophylaxis of norovirus infection.
IAVI Begins First-in-Human Phase 1 Trial of Single-Dose Marburg Virus Vaccine Candidate
[International AIDS Vaccine Initiative (IAVI)] IAVI announced today that the first participants have been vaccinated with a Marburg virus vaccine candidate in a Phase I clinical trial in the US. This first-in-human study is designed to evaluate the safety and immunogenicity of IAVI’s investigational rVSV∆G-MARV-GP vaccine candidate.
Acute and Chronic Infections Drive Distinct Trajectories in Human Memory CD4+ T Cell Formation
[Immunity] Using human hepatitis C virus infection as a model, researchers assessed the determinants of virus-specific CD4+ T cell immunity in acute, spontaneously cleared, chronic, and therapeutically cured infections.
T Cell Adaptation in Chronic Infections and Tumors
[Cellular & Molecular Immunology] The authors synthesize recent advances in the cellular and molecular profiling of chronically stimulated CD8+ T cells across chronic viral infection and cancer, focusing on regulatory networks, defining factors, and tissue-specific cues that govern functional adaptation and exploring emerging therapeutic reprogramming strategies.
Sex Differences in Immune Responses to Viruses, Bacteria, and Vaccines
[Nature Immunology] Fundamental sex differences in immune function shape divergent outcomes between male and female individuals in viral and bacterial infections, post-acute infection syndromes, and vaccine responses throughout the lifespan.
Pharmacological Reduction of Neutrophil Infiltration Reduces Clostridioides Difficile Infection Severity
[mBio] Scientists highlight neutrophil infiltration as a key driver of Clostridioides difficile-associated disease and identify innate immune modulation as a potential host-directed therapeutic strategy.
The Low-Density Lipoprotein Receptor LDLR Mediates Cellular Entry of Nonenveloped Hepatitis A Virus
[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that the low-density lipoprotein receptor binds near the fivefold vertex of the viral capsid, promoting receptor-mediated endocytosis and transport of nonenveloped hepatitis A virus from the extracellular milieu to late endolysosomes where it can bind gangliosides essential for late steps in entry.
Next-Generation Inhibitors of SARS-CoV-2 M Overcome the Deficiencies of Paxlovid
[Nature Communications] Scientists reported the discovery of next-generation SARS-CoV-2 SARS-CoV-2 main protease inhibitors that overcome the deficiencies of Paxlovid.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
