Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

Two Very Rare COVID Vaccine Side-Effects Detected in Global Study of 99 Million

[The Guardian] Two new but exceptionally rare Covid-19 vaccine side effects – a neurological disorder and inflammation of the spinal cord – have been detected by researchers in the largest vaccine safety study to date.

circRNA_SLC8A1 Promotes the Survival of Mycobacterium tuberculosis in Macrophages by Upregulating Expression of Autophagy-Related Protein SQSTM1/p62 to Activate the NF-κB Pathway

[Scientific Reports] Researchers found that miR-20b-5p expression was decreased, while sequestosome 1 (SQSTM1) protein expression was increased in a time- and dose-dependent manner in the human macrophage U937 in response to Mycobacterium tuberculosis infection.

CD20 CAR T-Cells Safely and Reversibly Ablate B-Cell Follicles in a Nonhuman Primate Model of HIV Persistence

[Molecular Therapy] In simian/human immunodeficiency virus (SHIV)-infected animals, CAR T cells were highly functional with rapid expansion and trafficking to tissue-associated viral sanctuaries including B cell follicles and gut-associated lymphoid tissues.

Liver Sinusoidal Endothelial Cell: An Important Yet Often Overlooked Player in the Liver Fibrosis

The authors update the various pathways by which liver sinusoidal endothelial cells are involved in the initiation and progression of liver fibrosis, including but...

Anna Rita Cantelmo: When the Blood Vessel Cells Malfunction

[Inserm] Passionate about vascular biology, Anna Rita Cantelmo has always wanted to conduct high-level research. Thanks to the Atip-Avenir funding she obtained in 2021, she has already identified key biological pathways.

Severe COVID-19 and Long COVID Are Associated with High Expression of STING,/em>, cGAS and IFN-α

[Scientific Reports] Investigators evaluated the association of cGAS and STING gene expression levels and plasma IFN-α, TNF-α and IL-6 levels with COVID-19 severity in acute infection and long COVID, based on analysis of blood samples from 148 individuals, 87 with acute COVID-19 and 61 in the post-COVID-19 period.

Anna Rita Cantelmo: When the Blood Vessel Cells Malfunction

[Inserm] Passionate about vascular biology, Anna Rita Cantelmo has always wanted to conduct high-level research. Thanks to the Atip-Avenir funding she obtained in 2021, she has already identified key biological pathways.

RNA–RNA Interactions Between Respiratory Syncytial Virus and miR-26 and miR-27 Are Associated with Regulation of Cell Cycle and Antiviral Immunity

[Nucleic Acids Research] Scientists adapted a biochemical method and analysis pipeline to identify targets of miRNAs in lung cells infected with respiratory syncytial virus.

Chlamydia trachomatis Enhances HPV Persistence Through Immune Modulation

[BMC Infectious Diseases] Researchers reported that Chlamydia trachomatis (CT) infection supported HPV persistence by further suppressing the functions of Langerhans cells (LCs); in particular, CT further activated the PI3K pathway and inhibited the MAPK pathways in LCs, and these pathways were frequently involved in the regulation of immune responses.

Rapid Development of Achalasia After SARS-CoV-2 Infection: Polymerase Chain Reaction Analysis of Esophageal Muscle Tissue

[American Journal Of Gastroenterology] Investigators prospectively evaluated esophageal muscle for SARS-CoV-2 from patients with rapid-onset achalasia post–COVID-19 and compare them with achalasia predating COVID-19 and achalasia with no COVID-19.

Incipient Functional SARS-CoV-2 Diversification Identified Through Neural Network Haplotype Maps

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists established haplotype self-organized maps as a means to dissect the composition of complex viral mutant spectra and to identify low-frequency haplotypes.

Human Transferrin Receptor Can Mediate SARS-CoV-2 Infection

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators identified human TfR, one of the most ubiquitously and highly expressed membrane components, as a receptor of SARS-CoV-2. TfR mediated SARS-CoV-2 infection by directly binding to the spike with high affinity and transporting the virus into the host cells.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.

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