Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

Aesculus hippocastanum Extract and the Main Bioactive Constituent β-Escin As Antivirals Agents Against Coronaviruses, Including SARS-CoV-2

[Scientific Reports] Investigators demonstrated that β-escin and Aesculus hippocastanum L. have antiviral and virucidal activities against SARS-CoV-2 and CCoV, revealing broad-spectrum antiviral activity against coronaviruses.

Mpox Virus Clade IIb Infected Cynomolgus Macaques via Mimic Natural Infection Routes Closely Resembled Human Mpox Infection

[Emerging Microbes & Infections] Scientists established an animal model by infecting cynomolgus macaques with the prevalent MPXV strain, WIBP-MPXV-001, and simulating its natural routes of infection.

Medcare Hospital Al Safa Performs Life-Saving Vascular Surgery to Restore Blood Flow to a 72-Year-Old British Expat’s Brain After a Stroke

[UAE News] Ms. Vivienne Alison Davidson, a 72-year-old UK expat, overcame severe carotid artery stenosis, a condition that caused her to have two recurrent strokes, through a complex surgical intervention carried out at Medcare Hospital Al Safa.

Extracellular Vesicles As Central Regulators of Blood Vessel Function in Cancer

[Science Signaling] The authors discuss the translational opportunities in targeting the dysfunctional tumor vasculature using extracellular vesicles (EV) and highlight the open questions in the field of EV biology that can be addressed using mass spectrometry–based proteomics analysis.

Hybrid Immunity and SARS-CoV-2 Antibodies: Results of the HEROES-RECOVER Prospective Cohort Study

[Clinical Infectious Diseases] From a cohort of health care personnel, first responders, and other frontline workers in six US states, researchers examined heterogeneity of the effect of hybrid immunity on SARS-CoV-2 antibody levels.

AI-Guided Pipeline for Protein–Protein Interaction Drug Discovery Identifies a SARS-CoV-2 Inhibitor

[Molecular Systems Biology] Scientists identified a compound that binds to NSP10 and inhibits its interaction with NSP16, while also disrupting the methyltransferase activity of the complex, and SARS-CoV-2 replication.

Engineered Dityrosine-Bonding of the RSV Prefusion F Protein Imparts Stability and Potency Advantages

[Nature Communications] Investigators showed that the prefusion conformation of respiratory syncytial virus fusion protein can be stabilized with two engineered dityrosine crosslinks, markedly improving its stability and shelf-life.

Antibody-Independent Protection Against Heterologous SARS-CoV-2 Challenge Conferred by Prior Infection or Vaccination

[Nature Immunology] Researchers showed, through studies in mouse models lacking antibodies but maintaining functional B cells and lymphoid organs, that immunity conferred by prior infection or mRNA vaccination can protect against SARS-CoV-2 challenge independently of antibodies.

Th2-Predominant Immune Response Underlies the Pathogenesis of Dengue

[Cytokine] The authors investigated and compared the immune response in clinically defined cohorts of Dengue with and without warning signs, with the aim of identifying immunological correlates of clinical disease and potential markers of disease severity.

The Ecto-Enzyme CD38 Modulates CD4 T Cell Immunometabolic Responses and Participates in HIV Pathogenesis

[Journal Of Leukocyte Biology] Investigators found that CD38’s extracellular glycohydrolase activity restricts metabolic reprogramming after TCR-engaging stimulation in Jurkat T CD4 cells, together with functional responses, while reducing intracellular NAD and NMN concentrations.

Correlates of Protection and Determinants of SARS-CoV-2 Breakthrough Infections 1 Year After Third Dose Vaccination

[BMC Medicine] Scientists evaluated antibody responses to SARS-CoV-2 spike and nucleocapsid antigens from Wuhan and variants of concern by Luminex and their role in preventing breakthrough infections 1 year after a third dose of mRNA vaccination, in a cohort of health care workers followed since the pandemic onset in Spain.

Non-Stem Cell-Derived Exosomes: A Novel Therapeutics for Neurotrauma

[Journal Of Nanobiotechnology] Investigators provide an in-depth exploration of the current methodologies, challenges, and future directions regarding the therapeutic role of non-stem cell-derived exosomes in neurotrauma.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.

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