Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

Subscribe|Follow Us On

The Mycobiome, Virome, and Archaeome in Gastrointestinal Cancers: Molecular Pathogenesis, and Therapeutic Intervention

June 3, 2026

[Molecular Cancer] The authors summarize current evidence on the compositional alterations of viruses, fungi, and archaea across the major types of gastrointestinal cancer, including colorectal, hepatocellular, gastric, pancreatic and esophageal/oral cancers.

Moderna and CEPI Expand Strategic Collaboration to Advance Potential Vaccine Against Bundibugyo Ebolavirus

June 3, 2026

[Moderna, Inc. ] Moderna, Inc. announced an expanded collaboration with the Coalition for Epidemic Preparedness Innovations (CEPI) to advance the development of a potential vaccine against Bundibugyo ebolavirus (BDBV), a cause of Ebola virus disease for which there are currently no licensed vaccines indicated.

Comprehensive Longitudinal Profiling Identifies Differential Frequency, Epitope Specificity, and Effector Function of CD8 T Cells across COVID-19 Disease Severities

June 3, 2026

[eBioMedicine] Scientists performed comprehensive longitudinal profiling of antigen-specific CD8+ T cell populations using DNA-barcoded peptide–HLA multimers, analyzing 553 SARS-CoV-2 epitopes across globally prevalent HLA alleles in patients with mild and severe COVID-19.

Epstein-Barr Virus (EBV) Infection Causes Human Germinal Center B Cell-Derived Lymphomas in the Absence of EBNA2 Expression

June 3, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that human tonsil germinal center B cells infected with an EBNA2-deleted EBV mutant proliferate on a CD40L/IL21-expressing feeder layer and form lymphomas in NSG mice that resemble human diffuse large B cell lymphomas (both ABC and GCB subtypes) and plasmablastic lymphomas.

Perturbation of RNA Homeostasis Impairs Mitochondrial Respiration during Poxvirus Infection through Excess RNA Accumulation

June 3, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that impaired RNA degradation in vaccinia virus–infected cells, due to either depletion of viral decapping enzymes or cellular exonuclease, severely compromises mitochondrial respiration and integrity.

Phosphoethanolamine Cytidylyltransferase 2 Integrates DAG Metabolism and TBK1 Activation to Regulate Antiviral Innate Immunity

June 3, 2026

[Proceedings of the National Academy of Sciences of the United States of America] Scientists demonstrated that inhibition of phosphoethanolamine cytidylyltransferase 2 (PCYT2), a key enzyme in phosphatidylethanolamine biosynthesis, promotes TANK-binding kinase 1 (TBK1) activation to enhance the antiviral innate immune response.

Trypanosoma cruzi Cell Atlas As a Single-Cell Resource for Understanding Parasite Population Heterogeneity and Differentiation

June 3, 2026

[Nature Communications] Investigators presented a cell atlas for the T. cruzi life cycle, based on single cell transcriptomes for over 31,000 cells and population-based transcriptomics. The atlas revealed many life cycle associated genes and can be utilised to accurately annotate life cycle stages.

Redundant and Distinct Mechanisms Suppress Innate Immune Activation during SARS-CoV-2 Infection

June 3, 2026

[PLoS Biology] Scientists used a SARS-CoV-2 bacterial artificial chromosome with en passant mutagenesis to recover a panel of 12 infectious recombinant SARS-CoV-2 viruses

A Pathogen lncRNA Secreted Into Rice Sequesters a Host miRNA for Virulence

June 3, 2026

[Nature] Researchers reported an RNA–RNA recognition mechanism governing pathogen–host interaction, mediated by a regulatory RNA-encoding DNA sequence that separately generates two complementary regulatory RNAs.

Gladstone Launches Center for PhAIge Therapy to Harness AI in the Fight Against Drug-Resistant Infections

June 3, 2026

[Gladstone Institutes] Gladstone Institutes has received an initial award of $2 million from the National Institute of Allergy and Infectious Diseases. This grant will establish the Center for PhAIge Therapy, a research center that will develop new phage-based treatments for antibiotic-resistant bacterial infections.

Recombinant Bombali ebolavirus in Cynomolgus Macaques As a Survival Model of Ebola Virus Disease

June 3, 2026

[Nature Communications] To estimate disease potential in humans, researchers challenged cynomolgus macaques with recombinant Bombali orthoebolavirus. Macaques exhibit hallmark features of Ebola virus disease, including vascular leak, lymphopenia, neutrophilia, and elevated inflammation markers.

Influenza Virus Antigenic Drift: Balancing Fitness and Immune Evasion

June 3, 2026

[Annual Review of Virology] The authors describe antibody targets of influenza viruses, how influenza viruses have evolved to evade these antibody specificities, and how epistasis helps maintain viral fitness.

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.