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Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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Trop-1/EpCAM Thr115 Is a Driver of Hyperproliferative Cell Repair and of Severe Lung Damage in COVID-19
[Iscience] Scientists discovered that the T115 Trop-1/EpCAM is a driver of cell growth, whereas M115 Trop-1/EpCAM has little, if any, cell growth induction capacity. TROP1/EPCAM knockout mice showed altered proliferation of ESCs.
Triacylglycerol Metabolism Is a Novel Target to Combat West Nile Virus Infection
[Emerging Microbes & Infections] To identify novel lipid-related therapeutic targets, researchers analyzed the infection-driven alterations in the CNS lipidome, the primary tissue supporting West Nile virus (WNV) replication. Their results indicated that the major alterations in the brain lipid content of WNV-infected mice corresponded to triacylglycerols.
Gilead Accelerates Global Access Planning for Investigational Once-Yearly Lenacapavir for HIV Prevention
[Gilead Sciences, Inc. ] Gilead Sciences, Inc. announced that it has expanded the scope of its six royalty-free voluntary licensing agreements for lenacapavir to include investigational once-yearly lenacapavir for HIV prevention as pre-exposure prophylaxis.
Co-Diagnostics and ReadyGo Collaborate to Evaluate Blood-Based Molecular Testing at the Point of Need, Starting with Ebola
[Co-Diagnostics, Inc. (BioSpace)] Co-Diagnostics, Inc. and ReadyGo Diagnostics Ltd announced that the companies are collaborating to evaluate the potential use of ReadyGo's sample-preparation technology with the Co-Dx PCR platform for blood-based molecular testing at the point of need, with an initial focus on decentralized Ebola virus detection and outbreak response.
Antagonism of Stress Granules Is Key to SARS-CoV-2 Infection and Pathogenesis
[Journal of Virology] Scientists evaluated a SARS-CoV-2 mutant (YF/F17A) that combines the NSP3 and N mutations. They found that loss of both stress granules-antagonizing functions attenuates SARS-CoV-2 replication in vitro.
Occult Hepatitis B Virus Infection
[Nature Reviews Gastroenterology & Hepatology] The authors describe the core knowledge of occult hepatitis B virus infection (OBI) and elaborate on challenges and future directions associated with OBI.
Convergent Evolution of Viral Nucleases Targeting Cyclic Dinucleotides
[PLoS Pathogens] Scientists synthesize recent advancements in our understanding of viral cyclic dinucleotide (CDN)-degrading nucleases. They discuss the therapeutic potential of targeting these nucleases with resistant CDN analogues and through structure-guided drug discovery.
Secreted ORF8 Reprograms Macrophages to Enhance SARS-CoV-2 Infection of Lung Epithelial Cells
[Science Advances] Researchers showed that secreted ORF8, a SARS-CoV-2 accessory protein, drives inflammatory lung pathology by increasing macrophage permissiveness to infection, triggering pyroptosis, and amplifying viral replication in alveolar epithelial cells.
Hantavirus: Biology, Immune Responses, and Pathogenesis
[Cell Death & Disease] Investigators synthesize the recent research on hantavirus biology, cellular entry mechanisms, and epidemiological characteristics, and particularly highlight that viral immune evasion and subsequent uncontrolled host immune responses act as the core pathogenic drivers.
HIV Cure: From Early Therapies to Cutting-Edge Strategies
[Journal of Neurovirology] The authors narrate the story of HIV treatment, tracing the evolution of therapeutic strategies from conventional antiretroviral therapies to innovative gene-editing and immunotherapeutic approaches.
ATG13 Promotes K63-Linked Polyubiquitination of MAVS via ASB1 to Restrict Influenza a Virus Replication
[Emerging Microbes & Infections] Scientists elucidated that autophagy-associated protein 13 (ATG13) restricts influenza A virus replication while potentiating the activation of the type I interferon pathway.
Undernutrition Enhances Host Attractiveness to Mosquitoes and Transmission of Mosquito-Borne Diseases
[Cell Research] Investigators found that undernourished mice were more attractive to multiple mosquito vectors. Undernutrition rendered mice more susceptible to mosquito-borne pathogens, such as dengue virus (DENV), thus facilitating the transmission of DENV both to and from mosquitoes.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
