In a historic move, the US government has today announced its support for waiving patent protections for COVID-19 vaccines, a measure aimed at boosting supplies so that people around the world can get the shots.
[Nature News]
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Category Archives: Immunology of Infectious Disease
Immunology of Infectious Disease NewsImmunology of Infectious Disease News is an online publication and email newsletter dedicated to covering the latest research and developments in the field of infectious diseases.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
In Shock Move, US Backs Waiving Patents on COVID Vaccines
T Cell Immune Discriminants of HIV Reservoir Size in a Pediatric Cohort of Perinatally Infected Individuals
Investigators demonstrated that T cell phenotypic signatures associate with viral reservoir size in a cohort of HIV vertically infected children and young adults under durable viral control, and who initiated anti-retroviral therapy under two years old.
[PLoS Pathogens]
Rinaldi, S., Armas, L. de, Dominguez-Rodríguez, S., Pallikkuth, S., Dinh, V., Pan, L., Gӓrtner, K., Pahwa, R., Cotugno, N., Rojo, P., Nastouli, E., Klein, N., Foster, C., Rossi, A. D., Giaquinto, C., Rossi, P., Palma, P., & Consortium, on behalf of E. (2021). T cell immune discriminants of HIV reservoir size in a pediatric cohort of perinatally infected individuals. PLOS Pathogens, 17(4), e1009533. https://doi.org/10.1371/journal.ppat.1009533 Cite
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Relationship of SARS-CoV-2-Specific CD4 Response to COVID-19 Severity and Impact of HIV-1 and Tuberculosis Co-Infection
Investigators assessed the magnitude, function and phenotype of SARS-CoV-2-specific CD4 T cells in 95 hospitalized COVID-19 patients and 38 non-COVID-19 patients, using flow cytometry.
[Journal of Clinical Investigation]
Riou, C., Bruyn, E. D., Stek, C., Daroowala, R., Goliath, R. T., Abrahams, F., Said-Hartley, Q., Allwood, B. W., Hsiao, N.-Y., Wilkinson, K. A., Arlehamn, C. S. L., Sette, A., Wasserman, S., & Wilkinson, R. J. (2021). Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and Tuberculosis co-infection. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI149125 Cite
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Differences in Host Immune Populations between Rhesus Macaques and Cynomolgus Macaque Subspecies in Relation to Susceptibility to Mycobacterium tuberculosis Infection
Researchers characterized the constituent monocyte and lymphocyte populations between macaque species, and profile other major immune cell subsets including: CD4+ and CD8+ T cells, NK cells, B cells, monocyte subsets and myeloid dendritic cells.
[Scientific Reports]
Sibley, L., Daykin-Pont, O., Sarfas, C., Pascoe, J., White, A. D., & Sharpe, S. (2021). Differences in host immune populations between rhesus macaques and cynomolgus macaque subspecies in relation to susceptibility to Mycobacterium tuberculosis infection. Scientific Reports, 11(1), 8810. https://doi.org/10.1038/s41598-021-87872-x Cite
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TTP-Mediated Regulation of mRNA Stability in Immune Cells Contributes to Adaptive Immunity, Immune Tolerance and Clinical App
Scientists summarize the effects of TTP-mediated regulation of mRNA stability in dendritic cells (DCs), focusing on DC maturation and antigen presentation, T cell activation and differentiation, immune tolerance and inflammation.
[RNA Biology]
Zhang, Y., Zhou, J., Wei, Z., Dong, H., Yang, D., Deng, Y., Li, J., Shi, S., Sun, Y., Lu, H., Yuan, J., Ni, B., Wu, Y., Tian, Y., & Han, C. (2021). TTP-mediated regulation of mRNA stability in immune cells contributes to adaptive immunity, immune tolerance and clinical applications. RNA Biology, 0(0), 1–7. https://doi.org/10.1080/15476286.2021.1917185 Cite
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‘There Are So Many Hurdles.’ Indian Scientists Plead with Government to Unlock COVID-19 Data
Indian researchers say they urgently need better access to data collected by government agencies to help them understand and fight the country’s devastating second pandemic wave. An open letter published on 29 April that has 740 signatories so far asks the government for access to databases on COVID-19 testing and genomic sequencing and urges it to remove other obstacles to research.
[ScienceInsider]
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Prevalent, Protective, and Convergent IgG Recognition of SARS-CoV-2 Non-RBD Spike Epitopes
Proteomic deconvolution of the immunoglobulin G (IgG) repertoire to the spike glycoprotein in convalescent subjects revealed that the response was directed predominantly against epitopes residing outside the receptor-binding domain.
[Science]
Voss, W. N., Hou, Y. J., Johnson, N. V., Delidakis, G., Kim, J. E., Javanmardi, K., Horton, A. P., Bartzoka, F., Paresi, C. J., Tanno, Y., Chou, C.-W., Abbasi, S. A., Pickens, W., George, K., Boutz, D. R., Towers, D. M., McDaniel, J. R., Billick, D., Goike, J., … Ippolito, G. C. (2021). Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes. Science. https://doi.org/10.1126/science.abg5268 Cite
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Ocugen Announces Studies Showing COVAXIN Potentially Effective against Three Key Variants of SARS-CoV-2
Ocugen, Inc. announced that in a new study, scientists at Indian Council of Medical Research-National Institute of Virology have found that COVAXIN demonstrated potential effectiveness against the Brazil variant of SARS-CoV-2, B.1.128.2.
[Ocugen, Inc.]
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PhysIQ, Department of Defense, Duke University, Johns Hopkins and HJF Partner to Study COVID-19
PhysIQ Inc., Johns Hopkins University, Duke University and The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. announced their collaboration to deploy physIQ’s platform to support a clinical trial to evaluate investigational products for early treatment and post-exposure prophylaxis of COVID-19.
[PhysIQ, Inc.]
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Six Patients with Dementia Went to Mexico for an Unproven Gene Therapy, a Biotech CEO Claims
Six patients with dementia traveled to Mexico last year to be injected with a gene therapy not authorized for use in the US, according to the CEO of a Seattle-area startup that wants to accelerate testing of unproven anti-aging medicines and views US drug safety regulations as a hindrance.
[STAT News]
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Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
Investigators showed that SARS-CoV-2 proteins synergized to counteract antiviral immune responses. For example, Nsp14 targeted the type I IFN receptor for lysosomal degradation, ORF3a prevented fusion of autophagosomes and lysosomes, and ORF7a interfered with autophagosome acidification.
[Cell Reports]
Hayn, M., Hirschenberger, M., Koepke, L., Nchioua, R., Straub, J. H., Klute, S., Hunszinger, V., Zech, F., Bozzo, C. P., Aftab, W., Christensen, M. H., Conzelmann, C., Müller, J. A., Badarinarayan, S. S., Stürzel, C. M., Forne, I., Stenger, S., Conzelmann, K.-K., Münch, J., … Sparrer, K. M. J. (2021). Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities. Cell Reports, 0(0). https://doi.org/10.1016/j.celrep.2021.109126 Cite
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