Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
AARS1 and AARS2 Sense L-Lactate to Regulate cGAS as Global Lysine Lactyltransferases
[Nature] Investigators identified the alanyl-tRNA synthetases AARS1 and AARS2 (AARS1/2) as intracellular l-lactate sensors required for l-lactate to stimulate the lysine lactylome in cells.
Targeted Recruitment of Immune Effector Cells for Rapid Eradication of Influenza Virus Infections
[Proceedings of The National Academy of Sciences of The United States of America] Scientists designed a bispecific small molecule that both inhibited influenza virus neuraminidase and recruited the immune system, thereby reducing the viral load in lethally infected mice much faster and more effectively than any current therapy.
Neurosymptomatic HIV-1 CSF Escape Is Associated with Replication in CNS T Cells and Inflammation
[Journal of Clinical Investigation] Researchers explored the source of neuropathogenesis and HIV-1 RNA in the cerebrospinal fluid (CSF) during neurosymptomatic HIV-1 CSF escape (NSE) by characterizing HIV-1 populations and inflammatory biomarkers in CSF from 25 individuals with NSE.
The Frequency of CD38+ Alveolar Macrophages Correlates with Early Control of M. tuberculosis in the Murine Lung
[Nature Communications] Investigators showed, through multi-modal single-cell RNA sequencing in a murine model, that different alveolar macrophage subsets played distinct roles in either advancing or controlling tuberculosis.
Murine Parainfluenza Virus Persists in Lung Innate Immune Cells Sustaining Chronic Lung Pathology
[Nature Microbiology] Using the murine parainfluenza virus Sendai, scientists demonstrated that viral protein and RNA persist in lung macrophages, type 2 innate lymphoid cells and dendritic cells long after the infectious virus was cleared.
Unveiling the Crucial Role of Ferroptosis in Host Resistance to Streptococcus agalactiae Infection
[Cell Death Discovery] The authors demonstrated that the occurrence of ferroptosis was essential for the host’s defense against group B Streptococcus infection in a mouse model of abdominal infection, with peritoneal macrophages identified as the primary cells undergoing ferroptosis.
Antiviral Innate Immune Memory in Alveolar Macrophages following SARS-CoV-2 Infection Ameliorates Secondary Influenza a Virus Disease
[Immunity] Single-cell analyses of airway-resident immune cells in a disease-relevant murine model of SARS-CoV-2 recovery revealed epigenetic reprogramming in alveolar macrophages following infection.
Broadly Potent Spike-Specific Human Monoclonal Antibodies Inhibit SARS-CoV-2 Omicron Sub-Lineages
[Communications Biology] Researchers reported the isolation of broad and potent neutralizing human monoclonal antibodies from a healthcare worker infected with SARS-CoV-2 early in the pandemic.
How Oxygenation Shapes Immune Responses: Emerging Roles for Physioxia and Pathological Hypoxia
[Nature Reviews Immunology] Investigators address the relevance of both physiological oxygenation and disease-associated hypoxia for immune cell functions, discussing the relevance of hypoxia for immune responses in the settings of tissue homeostasis, inflammation, infection, cancer and disease immunotherapy.
LJI Launches “America’s SHIELD” to Develop Life-Saving Herpesvirus Vaccines
[La Jolla Institute for Immunology] Vaccine researchers at La Jolla Institute for Immunology (LJI) have been awarded up to $49 million from the US Government’s Advanced Research Projects Agency for Health. LJI scientists will lead a national team to develop life-saving vaccines against a broad array of herpesviruses.
NIH Awards $9.8 million in Funding to Rosalind Franklin University Researchers for Projects Related to Brain Function and Diseases, Cancer and Parasitic Infections
[Rosalind Franklin University] Three Rosalind Franklin University scientists have been awarded approximately $9.8 million in funding from the National Institutes of Health (NIH) for research projects related to brain function and diseases, cancer and parasitic infections.
Grant Supports Vaccine Development to Protect Fetus from Cytomegalovirus
[Weill Cornell Medicine] Weill Cornell Medicine was awarded a $4.2 million Program Project Grant renewal from National Institute of Allergy and Infectious Diseases. This will fund the development of a vaccine that can prevent the cytomegalovirus (CMV) from being transmitted from mother to baby during pregnancy.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
