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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Innate Immune Cell Functions Contribute to Spontaneous HIV Control
[Current HIV/Aids Reports] The authors review the role of innate immune cells in shaping the viral reservoir and maintenance of long-term viral control of spontaneous Elite and Viremic HIV controllers.
Dyadic Receives $3 Million Grant to Develop Cost-Effective Monoclonal Antibodies for RSV and Malaria Using C1 Platform Technology
[Dyadic International, Inc.] Dyadic International, Inc. announced that it has been awarded a $3 million grant from the Gates Foundation for the cell line development of monoclonal antibodies targeting respiratory syncytial virus (RSV) and malaria utilizing the company’s proprietary C1 protein production platform to provide globally accessible treatment options for underserved populations.
Immunoinformatic Approach to Design T Cell Epitope-Based Chimeric Vaccine Targeting Multiple Serotypes of Dengue Virus
[Journal of Biomolecular Structure & Dynamics] Researchers designing a multi-epitope chimeric immunogen using the envelope protein of the dengue virus. MHC-I and MHC-II binding T cell epitopes were selected based on their antigen processing criteria.
A Vaccine Platform Targeting Lung-Resident Memory CD4+ T Cells Provides Protection against Heterosubtypic Influenza Infections in Mice and Ferrets
[Nature Communications] Scientists demonstrated that intranasal immunization with the NVT-adjuvanted vaccine provides improved protection against influenza virus infections by inducing the generation of CD4+ TRM cells in the lungs in a type I interferon-dependent manner.
Distinguish Active Tuberculosis with an Immune-Related Signature and Molecule Subtypes: A Multi-Cohort Analysis
[Scientific Reports] Researchers analyzed cases from multiple cohorts and get the signature that can distinguishlatent tuberculosis infection from active tuberculosis.
Assessing Human B Cell Responses to Influenza Virus Vaccines and Adjuvants in a PBMC-Derived In Vitro Culture System
[Vaccine] Investigators assessed whether B cells present in peripheral blood mononuclear cells responded to vaccines and reflected the effects of different vaccine formulations and adjuvants.
Structural Characterization of Human Monoclonal Antibodies Targeting Uncommon Antigenic Sites on Spike Glycoprotein of SARS-CoV
[Journal of Clinical Investigation] Scientists reported a monoclonal antibody COV1-65 encoded by the IGHV1-69 gene that recognized the N terminal domain of SARS-CoV S protein.
Characterizing the Pharmacological Interaction of the Antimalarial Combination Artefenomel-Piperaquine in Healthy Volunteers with Induced Blood-Stage Plasmodium falciparum to Predict Efficacy in Patients with Malaria
[BMC Medicine] Researchers retrospectively evaluated whether characterizing the pharmacological interaction of artefenomel-piperaquine antimalarial combination in a volunteer infection study would have enabled prediction of the Phase IIb study results.
Chronic Inflammation Degrades CD4 T Cell Immunity to Prior Vaccines in Treated HIV Infection
[Nature Communications] Scientists investigated inflammation, immune activation and antigen-specific T cell responses in HIV-uninfected and antiretroviral-treated HIV-infected people.
SARS-CoV-2 Variants and Bebtelovimab: Immune Escape Mechanisms Revealed by Computational Studies
[Physical Chemistry Chemical Physics] Investigators employed molecular dynamics to elucidate the binding mechanism between human-derived monoclonal antibody, bebtelovimab, and the receptor binding domain of the viral spike protein and the effects of mutations on this binding.
Avian TRIM13 Attenuates Antiviral Innate Immunity by Targeting MAVS for Autophagic Degradation
[Autophagy] Scientists identified the duck Anas platyrhynchos domesticus TRIM13 as a novel negative regulator of duck MAVS that mediated the antiviral innate immune response.
The Intestinal Microbiome and Cetobacterium somerae Inhibit Viral Infection through TLR2-Type I IFN Signaling Axis in Zebrafish
[Microbiome] Researchers used a rhabdoviral infection model in zebrafish, which allowed them to investigate the modes of action of microbiome-mediated antiviral effect.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
