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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Influenza A Hemagglutinin Virus-Like Particles Confer Protection against Influenza B Virus Infection
[Emerging Microbes & Infections] Researchers investigated the protective efficacy of influenza A/H1H3 virus-like particles against influenza B virus infections in mice.
Phenotypic Heterogeneity Defines B Cell Responses to Repeated SARS-CoV-2 Exposures through Vaccination and Infection
[Cell Reports] Scientists addressed the challenge in defining long-lived humoral memory for durable immunity against pathogens through longitudinal sampling over the course of SARS-CoV-2 mRNA vaccinations with or without breakthrough infection.
New Antibiotic Is Effective against Gonorrhea, Could Be First New Treatment since 1990s, Study Says
[CNN Health] A new type of antibiotic for treatment of urinary tract infections in women could also work against gonorrhea infections, a new study finds. This could put the medication, called gepotidacin, on track to become the first new antibiotic for gonorrhea since the 1990s.
ACE2 and TMPRSS2 Gene Expression Is Reduced Acutely in SARS-CoV-2 Patients but Returns to Normal with Recovery
[Scientific Reports] Scientists found that ACE2 and TMPRSS2 gene expression was temporarily reduced during the acute phase of SARS-CoV-2 infection presumably due to viral disruption of transcription.
MDA5 ISGylation Is Crucial for Immune Signaling to Control Viral Replication and Pathogenesis
[Proceedings of The National Academy of Sciences of The United States of America] Researchers generated knock-in mice in which the two major ISGylation sites of the RNA sensor MDA5 were mutated.
Noncanonical T Cell Responses Are Associated with Protection from Tuberculosis in Mice and Humans
[Journal of Experimental Medicine] By characterizing Mycobacterium tuberculosis (Mtb) infection in mouse strains that model the genetic heterogeneity of an outbred population, we identified strains that control Mtb comparably to a standard IFNγ-dependent mouse model but with substantially lower lung IFNγ levels.
Expression of SARS-CoV-2 Entry Receptor ACE2 in Human Brain and Its Association with Alzheimer’S Disease and COVID-19
[Molecular Psychiatry] The authors suggest that the expression of ACE2 may partly explain the link of Alzheimer’s disease with COVID-19 infection, hospitalization and mortality.
Cilnidipine Exerts Antiviral Effects In Vitro and In Vivo by Inhibiting the Internalization and Fusion of Influenza a Virus
[BMC Medicine] Investigators highlighted the promising anti-influenza A virus properties of cilnidipine both in vitro and in vivo, suggesting its potential as a clinical agent for emergencies against influenza outbreaks.
Generalization of Neoantigen-Based Tumor Vaccine by Delivering Peptide-MHC Complex via Oncolytic Virus
[EMBO Molecular Medicine] Investigators provided a powerful approach to enhance the universality and efficacy of neoantigen vaccines, meeting the urgent need for universal neoantigen vaccines in the clinic to facilitate the further development of tumor immunotherapy.
Prophylactic Antiviral Therapy and All-Cause Mortality in Cancer Patients with Hepatitis B E Antigen-Negative Chronic Hepatitis B Virus Infection Receiving Immunosuppressive Therapy
[JNCI-Journal of The National Cancer Institute] Investigators evaluated the association of prophylactic antiviral therapy with all-cause and cause-specific mortality in cancer patients.
Micro- and Nano-Bots for Infection Control
[Advanced Materials] The authors discuss the potential advantages of multi-drive propulsion, bioinspired, and artificial-intelligence-trained medical micro- and nano-bots, with a special focus on challenges and opportunities for their commercialization.
CHIKV mRNA Vaccines Encoding Conserved Structural/Envelope Proteins Confer Broad Cross-Lineage Protection against Infection
[Signal Transduction and Targeted Therapy] Scientists designed chikungunya virus (CHIKV) mRNA vaccines containing full-length structural proteins or part of structural proteins based on conserved sequences from 769 viral strains encompassing four lineages.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
