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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
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MicrobiotiX Completes Sentinel Cohort of its First-in-Human Clinical Trial of MP101 for Pneumonia
[MicrobiotiX (BioSpace)] MicrobiotiX announced the successful completion of the sentinel cohort of its first-in-human Phase I clinical trial evaluating MP101 in patients with pneumonia caused by Pseudomonas aeruginosa.
Will the mRNA Flu Shot Work Better Than a Regular Seasonal One? What the Science Says
[Nature] The US FDA granted approval to Moderna’s mRNA-based flu vaccine, mFLUSIVA, for adults aged 50–64, and accelerated approval for adults aged 65 and older.
Methicillin-Resistant Staphylococcus aureus
[Nature Reviews Disease Primers] The spectrum of diseases caused by Methicillin-resistant Staphylococcus aureus range from uncomplicated skin and soft-tissue infections to life-threatening invasive infections such as bacteraemia, pneumonia, osteomyelitis and endocarditis.
Potent Type-Specific De Novo Antibodies Complement Broadly Reactive Imprinted Antibodies in Immune Responses to SARS-CoV-2 Variants
[Nature Immunology] Researchers isolated and characterized hundreds of recall and de novo neutralizing monoclonal antibodies after sequential exposures to SARS-CoV-2 variants in ancestral-imprinted humans.
The Immunophenotype and Proviral Landscape of HIV-Infected CD4 T Cells during Antiretroviral Therapy
[Proceedings of the National Academy of Sciences of the United States of America] Scientists applied DAb-seq, a high-throughput method that combines single-cell DNA and surface protein sequencing, to profile ~527,000 CD4 T cells from the blood of six individuals on antiretroviral therapy.
Protein Landscape of the Chromatin Domains in the Malaria Parasite Plasmodium falciparum
[Cell Host & Microbe] Investigators presented a systematic proteomic characterization of the chromatin domains in Plasmodium falciparum, an ancient human pathogen with a unique genome composition and epigenetic blueprint.
Persistent Cytolytic CD8 T Cells Recognize SARS-CoV-2 and Herpesvirus Epitopes in Long COVID
[Cell Reports Medicine] Leveraging combinatorial tetramers, scientists profiled CD8+ T cells specific for SARS-CoV-2, as well as those for cytomegalovirus and Epstein-Barr virus, herpesviruses implicated in COVID-19 pathogenesis.
HLA Class I Escape Drives the Evolution of SARS-CoV-2 in Human Populations
[Proceedings of the National Academy of Sciences of the United States of America] Researchers studied the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the human leukocyte antigen (HLA) class I alleles common in human populations.
A Zika Virus Vaccine with E Protein Fusion Loop Mutations Protects via CD8+ T Cells
[Nature Microbiology] Researchers utilized DNA and RNA platforms to compare virus-like particle vaccines with premembrane and ZIKV envelope expressed either in the wild-type form or with fusion loop mutations, which limit antibody-dependent enhancement of infection.
Loss of Cellular RNA Homeostasis Contributes to MDA5 Activation during Virus Infection
[Nature Immunology] MDA5’s RNA agonists are not well defined. Scientists used single-nucleotide resolution crosslinking and immunoprecipitation to study its ligands.
Mitochondrial Dynamics in Orthoflavivirus Infection: Insights from Human and Mosquito Hosts
[npj Viruses] Mosquito-borne orthoflaviviruses alternate between vertebrates and mosquitoes, where they establish distinct infection outcomes. The authors discuss how mitochondrial dynamics and inter-organelle communication may shape orthoflavivirus replication and infection outcome.
DGAT1 Regulates Macrophage Pyroptosis during Klebsiella pneumoniae Infection
[Cell Death Discovery] Researchers identified diacylglycerol acyltransferase-1 (DGAT1) as a critical regulator of macrophage pyroptosis during infection with a classical Klebsiella pneumoniae isolate.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
