Immunology of Infectious Disease News

Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.

COVID-19 and Asthma Onset in Children

[Pediatrics] This retrospective cohort study examined children ages 1 to 16 within the Children’s Hospital of Philadelphia Care Network who received PCR testing for SARS-CoV-2 between March 1, 2020 and February 28, 2021.

HIV-1–Infected T Cell Clones Are Shared Across Cerebrospinal Fluid and Blood During ART

[JCI Insight] Researchers profiled people with HIV and uninfected controls through single-cell transcriptomic and T cell receptor sequencing to understand the dynamics of HIV persistence in the central nervous system.

Indirect CD4+ T Cell Protection against Mouse Gamma-Herpesvirus Infection via Interferon Gamma

[Journal Of Virology] Scientists showed that the action of IFNγ was indirect, as CD4+ T cell-mediated control of type 1 alveolar epithelial cells infection depended on IFNγ receptor expression in CD11c+ cells.

SARS-CoV-2 nsp15 Preferentially Degrades AU-Rich dsRNA via Its dsRNA Nickase Activity

[Nucleic Acids Research] The authors prepared numerous RNA substrates, including both long substrates mimicking the viral genome and short defined RNA, to clarify the substrate preference and cleavage pattern of SARS-CoV-2 nsp15.

Canada Likely to Miss WHO’s Hepatitis C Elimination Target, Research Shows

[University of Waterloo] Canada will not reach the original World Health Organization's (WHO) target of eliminating the Hepatitis C virus by 2030 and lags in comparison to other developed countries, a new study led by researchers at the University of Waterloo has found.

Inflammation and Cytomegalovirus Viremia during Pregnancy Drive Sex-Differentiated Differences in Mortality and Immune Development in HIV-Exposed Infants

[Nature Communications] In a secondary analysis of the SHINE trial in rural Zimbabwe researchers explored biological pathways underlying infant mortality, and maternal factors shaping immune development in HIV-exposed uninfected infants.

Single Cell Analysis Unveils B Cell-Dominated Immune Subtypes in HNSCC for Enhanced Prognostic and Therapeutic Stratification

[International Journal Of Oral Science] Using single-cell RNA sequencing data from the Gene Expression Omnibus database, the study identified distinct gene expression patterns in tumor-infiltrating B cells (TIL-BAs). Head and neck squamous cell carcinoma samples were categorized into TIL-Bs inhibition and TIL-Bs activation groups using unsupervised clustering.

Biofabrication Directions in Recapitulating the Immune System-on-a-Chip

[Advanced Healthcare Materials] The authors cover the state of the art in the intricate landscape of immune organs-on-chip models, shedding light on the pivotal role of biofabrication technologies in bridging the gap between conceptual design and physiological relevance.

SARS-CoV-2 Infection Activates Inflammatory Macrophages in Vascular Immune Organoids

[Scientific Reports] The authors established vascular immune organoids from human pluripotent stem cells and examined the effect of SARS-CoV-2 infection.

Virological, Innate, and Adaptive Immune Profiles Shaped by Variation in Route and Age of Host in Murine Cytomegalovirus Infection

[Applied And Environmental Microbiology] To assess the role of route and age at infection in modeling human cytomegalovirus in mice, scientists infected prepubescent and young sexually mature C57BL/6 mice intranasally, a likely physiological route in humans) and intraperitoneally, which is frequently used experimental route, and is possibly akin to transplant-mediated infection.

Secreted Phospholipase PLA2G2E Contributes to Regulation of T Cell Immune Response Against Influenza Virus Infection

[Journal Of Virology] Investigators demonstrated that Pla2g2e-/- mice had significantly lower survival rates and higher viral loads in lungs compared to wild-type mice following influenza virus infection.

Lessons in Persistence: New Long COVID Trials AIm To Clear LIngering Virus

[Science Insider] Long COVID has been a vexing foe, but these clinical trials mark a new chapter. They’re the first targeting the syndrome’s underlying biology, including the one Hayden joined, focus on a key question: Is lingering SARS-CoV-2 virus behind patients’ symptoms?

Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.