Interferon-Induced Transmembrane Protein-1 Competitively Blocks Ephrin Receptor A2-Mediated Epstein–Barr Virus Entry into Epithelial Cells

Scientists reported that interferon-induced transmembrane protein-1 (IFITM1) inhibited Ephrin receptor A2 (EphA2)-mediated Epstein–Barr virus (EBV) entry into epithelial cells (ECs). RNA-sequencing and clinical sample analysis showed reduced IFITM1 in EBV-positive ECs and a negative correlation between IFITM1 level and EBV copy number.