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Jamie Kang
Immunology of Infectious Disease News
Strong Immune Response and Protection against Brucella abortus by Omp25 and BP26 mRNA Vaccine Candidates
[International Immunopharmacology] Researchers focused on the outer membrane proteins Omp25 and BP26 of Brucella as targets, employing a multidimensional strategy to develop novel mRNA vaccines and systematically evaluate their immunoprotective efficacy.
Immunology of Infectious Disease News
Intranasal Vaccination with Multi-Neuraminidase and M2e Virus-Like Particle Vaccine Results in Greater Mucosal Immunity and Protection against Influenza Than Intramuscular Injection
[Vaccine] Scientists reported that multi-subtype neuraminidase and M2 ectodomain repeatvirus-like particle vaccine conferred higher efficacy of broad cross-protection after two doses of intranasal delivery than intramuscular injection.
Immunology of Infectious Disease News
Impact of Staphylococcus aureus Colonization and Skin Abscesses on Formation of Human anti-αGal Antibodies
[Medical Microbiology and Immunology] Investigators studied the impact of Staphylococcus aureus colonization and abscess events on plasma anti-αGal antibody levels.
Hematopoiesis News
Advances in Host-Directed Therapy for Tuberculosis and HIV Coinfection: Enhancing Immune Responses
[Trends In Microbiology] Scientists explore key host-directed therapys, including cytokine therapy, CAR-T cell therapy and immune checkpoint inhibitors, which target Mycobacterium tuberculosis-infected cells, enhance immune responses, and mitigate inflammation.
Hematopoiesis News
Molecular Mechanisms of Viral Oncogenesis in Haematological Malignancies: Perspectives from Metabolic Reprogramming, Epigenetic Regulation, and Immune Microenvironment Remodeling
[Experimental Hematology & Oncology] The authors delve into the contributions of various known viruses—specifically Epstein-Barr virus, HIV, human T cell leukemia virus type 1, Kaposi’s sarcoma-associated herpesvirus, human cytomegalovirus, hepatitis B virus, hepatitis C virus, and human papillomavirus—in the development of haematological malignancies.
Immunology of Infectious Disease News
Invivyd Announces New Pipeline Discovery Program Focused on Monoclonal Antibody Treatment for Measles
[Invivyyd, Inc.] Invivyd, Inc. announced it has initiated a discovery program for a measles monoclonal antibody.
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Effects of Bisphenol A and Retinoic Acid Exposure on Neuron and Brain Formation: a Study in Human Induced Pluripotent Stem Cells and Zebrafish Embryos
[Environmental Health Perspectives] The authors used hiPSCs and zebrafish embryos to investigate whether co-exposure to bisphenol A and exogenous retinoic acid (RA) can potentiate HOX gene expression and exert pleiotropic effects on RA signaling.
IPS HEART Granted Orphan Drug Designation in the EU for Becker Muscular Dystrophy
[IPS Heart (Businesswire)] IPS HEART has been awarded orphan drug designation in the EU by the European Medicines Agency for GIVI-MPCs unique ability to create new muscle with 100% full length dystrophin in Becker Muscular Dystrophy.
Proteogenomic Reprogramming to a Functional Human Blastomere-Like Stem Cell State via a PARP-DUX4 Regulatory Axis
[Cell Reports] Investigators showed that conventional hPSCs cultured with non-specific tankyrase-PARP1-inhibited conditions underwent proteogenomic reprogramming to functional blastomere-like tankyrase/PARP inhibitor-regulated naive stem cells.