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Jamie Kang

The BCR::ABL1 Tyrosine Kinase Inhibitors Ponatinib and Nilotinib Differentially Affect Endothelial Angiogenesis and signaling

[Molecular and Cellular Biochemistry] Scientists investigated the effects of three BCR::ABL1 inhibitors, ponatinib, nilotinib and imatinib, on angiogenesis and signaling in human endothelial cells in response to vascular endothelial growth factor.

Novel Immunomodulatory Properties of Adenosine Analogs Promote Their Antiviral Activity Against SARS-CoV-2

[EMBO Reports] In the case of remdesivir, investigators showed that immunomodulatory properties are due to its metabolite, GS-441524, acting as an adenosine A2A receptor antagonist. Their findings supported a new rationale for the design of next-generation antiviral agents with dual - immunomodulatory and intrinsic - antiviral properties.

In Vitro and In Vivo Inhibition of the Host TRPC4 Channel Attenuates Zika Virus Infection

[EMBO Molecular Medicine] Researchers investigated whether TRPCs might be involved in the pathogenesis of Zika virus (ZIKV) infection. They found that ZIKV infection increases TRPC4 expression in host cells via the interaction between the ZIKV-NS3 protein and CaMKII, enhancing TRPC4-mediated calcium influx.

A Novel Murine Model Mimicking Male Genital Neisseria Species Infection Using Neisseria musculi

[Biology of Reproduction] Scientists inoculated mice via the intrapenile route with N. musculi. THey assessed bacterial burden throughout the male reproductive tract, the systemic and tissue-specific immune response two weeks postinfection, and the effect of infection on sperm health.

Specific CD4+ T Cell Phenotypes Associate with Bacterial Control in People Who ‘Resist’ Infection with Mycobacterium tuberculosis

[Nature Immunology] Researchers found that Mtb-specific T cells in resisters (RSTR) were clonally expanded, confirming the priming of adaptive immune responses following Mtb exposure. RSTR CD4+ T cells showed enrichment of TH17 and regulatory T cell-like functional programs compared to Mtb-specific T cells from individuals with latent Mtb infection.

Acquired Epidermodysplasia Verruciformis Syndrome in HIV-Infected Patients: A Systematic Review

[Archives of Dermatological Research] Congenital epidermodysplasia verruciformis is a Genodermatosis linked to different inheritance patterns and mutations of the EVER1/TMC6 and EVER2/TMC8 genes. There is an acquired form (AEV) associated with immunodeficiency states, including HIV infection; however, the literature about AEV is limited and imprecise.

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Clinical Implications of Wnt Pathway Genetic Alterations in Men with Advanced Prostate Cancer

[Prostate Cancer and Prostatic Diseases] Investigators utilized the Prostate Cancer Precision Medicine Multi-Institutional Collaborative Effort clinical-genomic database for this retrospective analysis.

Targeting Valine Catabolism to Inhibit Metabolic Reprogramming in Prostate Cancer

[Cell Death & Disease] Through the suppression of branched-chain amino acid (BCAA) availability, researchers reported significantly reduced lipid content, strongly indicating that BCAAs were important lipogenic fuels in prostate cancer.

Embryonic Microenvironment Suppresses YY1 and YY1-Related Genes in Prostate Cancer Stem Cells

[Pathology - Research and Practice] To investigate the embryonic microenvironment impact on Yin yang 1 (YY1) expression in CSC populations, firstly cancer stem cells (CSCs) were microinjected into the inner cell mass of blastocysts and then prostate CSCs were co-cultured with blastocysts.