Jamie Kang

[Molecular Cancer] Through internal and external verification of randomly selected Nab-paclitaxel combined with gemcitabine (AG)-resistant patient-derived organoid (PDO) and PDO xenograft models, scientists discovered for the first time that the classic anti-inflammatory drug sulindac K-80003, an inhibitor of the PI3K/Akt pathway that we focused on, promoted sensitization in half of AG-resistant pancreatic ductal adenocarcinoma cases.

Retinal organoids, a valuable model system, were employed in combination with phosphorodiamidate morpholino oligos to assess the role of exon 4 alternative splicing in the development of human retina. [nan]

[Cell Death Discovery] The authors review the organoid models for the female reproductive system, focusing on the cancer research advancements. It discusses the methods for constructing tumor organoids of the female reproductive tract and summarizes the limitations of current research.

[Gut] Researchers assessed the dynamic of circulating tumour DNA in patients with HCC. They analysed 772 plasmas from 173 patients with HCC collected at the time of diagnosis or treatment, 24 hours after locoregional treatment, and during follow-up.

[Journal of Ethnopharmacology] Scientists investigated the key pathways and target genes of Qianggan Ruanjian Pill that attenuated liver fibrosis and elucidated the underlying mechanisms.

[Advanced Science] To determine the role of ASH1L in vivo, transgenic mice with conditional Ash1l depletion in the hepatocyte cell lineage or HSCs were generated, and these mice were challenged in a diethylnitrosamine/carbon tetrachloride-induced model of liver fibrosis and HCC.