Jamie Kang

Muscle Cell News

LMNA P.H222P Mutation Causes Contractile Dysfunction via Impaired Mitochondrial Calcium Uptake in Human Cardiac Laminopathy

[Cardiovascular Research] The authors established a direct mechanistic link between nuclear envelope dysfunction and impaired mitochondrial function, and highlight the mitochondrial calcium uniporter complex as a potential therapeutic target in LMNA-related cardiomyopathy.

Muscle Cell News

FAP-Derived CCL2 Is Required for Adequate Monocyte/Macrophage Infiltration to Support Acute Skeletal Muscle Injury Repair

[iScience] Investigators identified fibro/adipogenic progenitors (FAPs) as the primary source of CCL2 in acutely injured muscle, where the pro-inflammatory subcluster of FAPs expanded rapidly and expressed the highest level of CCL2.

Muscle Cell News

Molecular Mechanisms Underlying FCCP-Induced Mitophagyin Human Airway Smooth Muscle Cells

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Researchers hypothesized that, in human airway smooth muscle cells, carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP)-induced mitochondrial depolarization activates the PINK1-Parkin-mediated mitophagy pathway, culminating in the clearance of damaged mitochondria.

Muscle Cell News

Smooth Muscle Cell Spheroids As 3D Model of Phenotypic Plasticity and Matrix Deposition Revealed by 2D-3D Proteomics

[Scientific Reports] Researchers established a scaffold-free 3D spheroid model of murine and human aortic vascular smooth muscle cells derived from heart failure patients to mimic their multicellular organization, cell plasticity, and interactions with the extracellular matrix.

Muscle Cell News

Single-Cell Resolution of Skeletal Muscle Aging: Current Paradigms and Perspectives

[Ageing Research Reviews] Scientists summarize current progress in single-cell technology with respect to skeletal muscle aging. They focused on specific molecular characteristics and interaction networks of muscle fiber, satellite, and immune cells during aging.

Muscle Cell News

The Local-Systemic Axis of the Skeletal Muscle Secretome

[Trends In Endocrinology and Metabolism] Using skeletal muscle and endurance exercise as a model system, scientists defined a local–systemic secretome axis shaped by spatial organization, stimulus-specific programs, temporal dynamics, extracellular processing, and paracrine circuitry.

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Lupus Foundation of America Awards Grants to Early Career Scientists Advancing Understanding of Lupus and Targeted Treatment Pathways

[Lupus Foundation of America] The Lupus Foundation of America announced the recipients of the 2026 Gary S. Gilkeson Career Development Award. The two-year grant supports early career scientists at a pivotal time in their professions, providing funding for critical research studies and mentorship to foster the growth of the lupus research field.

UV Irradiation Drives Lineage-Specific MITF-Mediated Transcription of PD-L1 to Confer Immune Tolerance to UV-Mutated Melanocytes

[Immunity] Researchers investigated whether melanocyte-intrinsic transcriptional program(s) underlie immune tolerance to mutations resulting from UV radiation exposure.

Metabolic-Epigenetic Crosstalk in Innate Immune Cell Plasticity Within the Tumor Microenvironment

[Experimental & Molecular Medicine] Emerging evidence highlights the intricate interplay between metabolic reprogramming and epigenetic modifications in macrophages, neutrophils, and other innate immune populations within the tumor microenvironment.

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Jamie Kang

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