Claudin-7 Is Essential for the Maintenance of Colonic Stem Cell Homoeostasis via the Modulation of Wnt/Notch Signaling

Investigators revealed that Cldn-7 deletion disrupts the self-renewal and differentiation of colonic stem cells alongside the formation of colonic organoids in vitro. Additionally, these Cldn-7 knockout models exhibited heightened susceptibility to experimental colitis, limited epithelial repair and regeneration, and increased differentiation toward the secretory lineage.